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https://www.readbyqxmd.com/read/29793042/aminergic-neuromodulation-of-associative-visual-learning-in-harnessed-honey-bees
#1
Nino Mancini, Martin Giurfa, Jean-Christophe Sandoz, Aurore Avarguès-Weber
The honey bee Apis mellifera is a major insect model for studying visual cognition. Free-flying honey bees learn to associate different visual cues with a sucrose reward and may deploy sophisticated cognitive strategies to this end. Yet, the neural bases of these capacities cannot be studied in flying insects. Conversely, immobilized bees are accessible to neurobiological investigation but training them to respond appetitively to visual stimuli paired with sucrose reward is difficult. Here we succeeded in coupling visual conditioning in harnessed bees with pharmacological analyses on the role of octopamine (OA), dopamine (DA) and serotonin (5-HT) in visual learning...
May 21, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29791774/serotonergic-regulation-of-insulin-secretion
#2
REVIEW
Luis Rodrigo Cataldo Bascuñan, Claire Lyons, Hedvig Bennet, Isabella Artner, Malin Fex
The exact physiological role for the monoamine serotonin (5-HT) in modulation of insulin secretion is yet to be fully understood. Although the presence of this monoamine in islets of Langerhans is well established, it is only with recent advances that the complex signaling network in islets involving 5-HT is being unraveled. With more than fourteen different 5-HT receptors expressed in human islets, and receptor independent mechanisms in insulin producing β-cells, our understanding of 5-HT's regulation of insulin secretion is increasing...
May 23, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29782941/dopamine-and-serotonin-metabolism-associated-with-morphine-reward-and-its-inhibition-with-buspirone-a-study-in-the-rat-striatum
#3
Darakhshan Jabeen Haleem, Shazia Nawaz, Tabinda Salman
Adaptations within the nucleus accumbens (NAc) and caudate nucleus (CN) dopamine neurotransmission are involved in behavioral sensitization and enhanced incentive motivation towards drug paired stimuli which lead to drug addiction. Serotonin (5-hydroxytryptamine; 5-HT) can modulate dopamine neurotransmission to reduce rewarding effects of drugs of abuse. A recent study from our laboratory shows that rewarding effects of morphine are inhibited in rats co-treated with buspirone. To understand the neurochemical mechanism involved in morphine addiction and its inhibition with buspirone, present study determines the effects of buspirone, morphine and their co-administration on the metabolism of serotonin and dopamine in the NAc and CN...
May 18, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29778989/involvement-of-serotonin-in-crayfish-hematopoiesis
#4
Chadanat Noonin
Serotonin (5-HT) is a conserved monoamine neurotransmitter that has several physiological functions both in vertebrates and invertebrates. In addition to its well-known function in the central nervous system, 5-HT also participates in peripheral system. However, in crustaceans, the knowledge about peripheral functions of 5-HT is limited. In this study, a role of 5-HT in hematopoiesis in crayfish, Pacifastacus leniusculus, was investigated. The presence of 5-HT in crayfish plasma and the effect of 5-HT injection on hemocyte number were examined...
May 4, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29775613/suppression-of-nlrp3-inflammasome-attenuates-stress-induced-depression-like-behavior-in-nlgn3-deficient-mice
#5
Ze-Qun Li, Zhi-Yuan Yan, Bo-Jun Lan, Yi-Qun Dong, Ye Xiong
Depression, regulated by central nervous system (CNS), is a significant inflammatory disorder. Neuroligin3 (NLGN3) has been implicated in brain functions. In the study, a chronic unpredictable mild stress (CUMS) model in wild type (WT) or NLGN3-knockout (KO) mice was established to explore the role of NLGN3 in regulating depression and to reveal the underlying molecular mechanism. The results indicated that NLGN3-knockout markedly reversed the loss of body weight, the reduction of sucrose consumption, the decrease of immobile time in the forced swimming tests (FST) and tail suspension tests (TST) induced by CUMS paradigm...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29774428/inter-individual-differences-in-serotonin-and-glutamate-co-transmission-reflect-differentiation-in-context-induced-conditioned-50-khz-usvs-response-after-morphine-withdrawal
#6
Adam Hamed, Miron Bartosz Kursa
A growing body of research provides compelling evidence that in rats 50-kHz USVs are a form of expression of positive emotions. Context-induced 50-kHz USVs emission is variable among rats, indicating individual differences in contextual response bound up with pharmacological reward. The aims of this study were to: extract the most important neurotransmitters related to context-induced conditioned 50-kHz USVs response; find biological basis of existing inter-individual differences in context-induced conditioned 50-kHz USVs response; create a model of all-to-all neurotransmitters correlations...
May 17, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29773855/the-anxiolytic-like-effects-of-ginsenoside-rg3-on-chronic-unpredictable-stress-in-rats
#7
Jia-Ning Xu, Li-Fang Chen, Jun Su, Zhi-Li Liu, Jie Chen, Qing-Fen Lin, Wei-Dong Mao, Dong Shen
The present study is to evaluate the anxiolytic-like activities underlying ginsenoside Rg3 (GRg3). The anxiolytic-like activities were induced by GRg3 (20 and 40 mg/kg, i.g), evidenced by blocking the decreased time and entries in the open arms in elevated plus maze test and by reversing the increased latency to feed in novelty-suppressed feeding test. In addition, the decreased levels on progesterone, allopregnanolone, serotonin (5-HT) in the prefrontal cortex and hippocampus of chronic unpredictable stress (CUS) were blocked by GRg3 (20 and 40 mg/kg, i...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29762664/behavioral-and-serotonergic-changes-in-the-frontal-cortex-following-methamphetamine-self-administration
#8
Lisa M McFadden, Rebecca Cordie, Tamee Livermont, Andrew Johansen
Background: Methamphetamine (METH) use is associated with a variety of negative health outcomes including psychosis. The frontal cortex serotonin (5-HT)-2 receptors are thought to contribute to psychosis-like behaviors. This study investigated changes in serotonergic markers in the frontal cortex following METH self-administration and hallucinogenic drug-induced behavior. Methods: Consistent with previously published studies, freely-cycling male and female rats were allowed to self-administer METH (Males: 0...
May 14, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29757463/depression-related-behavioural-and-neuroendocrine-changes-in-the-spontaneously-diabetic-torii-sdt-fatty-rat-an-animal-model-of-type-2-diabetes-mellitus
#9
Katsuya Sakimura, Tatsuya Maekawa, Kazuo Sasagawa, Yukihito Ishii, Shin-Ichi Kume, Takeshi Ohta
Depression is one of the most common psychiatric diseases and is commonly comorbid with type 1 or 2 diabetes mellitus (DM). However, the pathophysiology underlying the depressive state in DM remains poorly understood. Animal models are useful tools to investigate the association between depression and DM. In the present study we investigated whether the Spontaneously Diabetic Torii (SDT) fatty rat, a novel animal model of type 2 DM, shows depression-related features. We assessed depression-like behaviour, hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, and neurotransmitter levels in the brain...
May 14, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29754752/hippocampal-5-ht-input-regulates-memory-formation-and-schaffer-collateral-excitation
#10
Catia M Teixeira, Zev B Rosen, Deepika Suri, Qian Sun, Marc Hersh, Derya Sargin, Iva Dincheva, Ashlea A Morgan, Stephen Spivack, Anne C Krok, Tessa Hirschfeld-Stoler, Evelyn K Lambe, Steven A Siegelbaum, Mark S Ansorge
The efficacy and duration of memory storage is regulated by neuromodulatory transmitter actions. While the modulatory transmitter serotonin (5-HT) plays an important role in implicit forms of memory in the invertebrate Aplysia, its function in explicit memory mediated by the mammalian hippocampus is less clear. Specifically, the consequences elicited by the spatio-temporal gradient of endogenous 5-HT release are not known. Here we applied optogenetic techniques in mice to gain insight into this fundamental biological process...
May 8, 2018: Neuron
https://www.readbyqxmd.com/read/29752984/antinociceptive-effects-of-the-antidepressant-phenelzine-are-mediated-by-context-dependent-inhibition-of-neuronal-responses-in-the-dorsal-horn
#11
Liam E Potter, Suzanne Doolen, Katherine Mifflin, Gustavo Tenorio, Glen Baker, Bradley K Taylor, Bradley J Kerr
The putative strong anti-nociceptive properties of the antidepressant phenelzine (PLZ) have not been widely explored as a treatment for pain. Antinociceptive effects of PLZ were identified in the formalin model of tonic pain (Mifflin et al. 2016) and in allodynia associated with experimental autoimmune encephalomyelitis, (EAE) a mouse model of multiple sclerosis (Potter et al. 2016). Here, we further clarify the specific types of stimuli and contexts in which PLZ modulates nociceptive sensitivity. Our findings indicate that PLZ selectively inhibits ongoing inflammatory pain while sparing transient reflexive and acute nociception...
May 9, 2018: Neuroscience
https://www.readbyqxmd.com/read/29751614/effects-of-dietary-acute-tryptophan-depletion-atd-on-npy-serum-levels-in-healthy-adult-humans-whilst-controlling-for-methionine-supply-a-pilot-study
#12
Janice W Y Wong, Hugo A E Morandini, Vita L S Dingerkus, Tilman J Gaber, Kevin C Runions, Pradeep Rao, Simone Mahfouda, Katrin Helmbold, Sarah Bubenzer-Busch, Rebecca Koenemann, Richard M Stewart, Florian D Zepf
Central nervous serotonin (5-HT) can influence behaviour and neuropsychiatric disorders. Evidence from animal models suggest that lowered levels of neuropeptide Y (NPY) may have similar effects, although it is currently unknown whether decreased central nervous 5-HT impact NPY concentrations. Given that the production of NPY is dependent on the essential amino acid methionine (MET), it is imperative to account for the presence of MET in such investigations. Hence, this study sought to examine the effects of acute tryptophan depletion (ATD; a dietary procedure that temporarily lowers central nervous 5-HT synthesis) on serum concentrations of NPY, whilst using the potential renal acid load indicator (PRAL) to control for levels of MET...
May 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29748774/structural-determinants-influencing-halogen-bonding-a-case-study-on-azinesulfonamide-analogs-of-aripiprazole-as-5-ht-1a-5-ht-7-and-d-2-receptor-ligands
#13
Krzysztof Marciniec, Rafał Kurczab, Maria Książek, Ewa Bębenek, Elwira Chrobak, Grzegorz Satała, Andrzej J Bojarski, Joachim Kusz, Paweł Zajdel
A series of azinesulfonamide derivatives of long-chain arylpiperazines with variable-length alkylene spacers between sulfonamide and 4-arylpiperazine moiety is designed, synthesized, and biologically evaluated. In vitro methods are used to determine their affinity for serotonin 5-HT1A , 5-HT6 , 5-HT7 , and dopamine D2 receptors. X-ray analysis, two-dimensional NMR conformational studies, and docking into the 5-HT1A and 5-HT7 receptor models are then conducted to investigate the conformational preferences of selected serotonin receptor ligands in different environments...
May 11, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29748506/dietary-neurotransmitters-a-narrative-review-on-current-knowledge
#14
REVIEW
Matteo Briguglio, Bernardo Dell'Osso, Giancarlo Panzica, Antonio Malgaroli, Giuseppe Banfi, Carlotta Zanaboni Dina, Roberta Galentino, Mauro Porta
Foods are natural sources of substances that may exert crucial effects on the nervous system in humans. Some of these substances are the neurotransmitters (NTs) acetylcholine (ACh), the modified amino acids glutamate and γ-aminobutyric acid (GABA), and the biogenic amines dopamine, serotonin (5-HT), and histamine. In neuropsychiatry, progressive integration of dietary approaches in clinical routine made it necessary to discern the more about some of these dietary NTs. Relevant books and literature from PubMed and Scopus databases were searched for data on food sources of Ach, glutamate, GABA, dopamine, 5-HT, and histamine...
May 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29738870/comparison-of-transitional-vs-surgical-menopause-on-monoamine-and-amino-acid-levels-in-the-rat-brain
#15
Tao Long, Jeffrey K Yao, Junyi Li, Ziv Z Kirshner, Doug Nelson, George G Dougherty, Robert B Gibbs
Loss of ovarian function has important effects on neurotransmitter production and release with corresponding effects on cognitive performance. To date, there has been little direct comparison of the effects of surgical and transitional menopause on neurotransmitter pathways in the brain. In this study, effects on monoamines, monoamine metabolites, and the amino acids tryptophan (TRP) and tyrosine (TYR) were evaluated in adult ovariectomized (OVX) rats and in rats that underwent selective and gradual ovarian follicle depletion by daily injection of 4-vinylcyclohexene-diepoxide (VCD)...
May 5, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29733594/development-of-a-fluorescent-bodipy-probe-for-visualization-of-the-serotonin-5-ht1a-receptor-in-native-cells-of-the-immune-system
#16
Gloria Hernandez-Torres, Ernesto Enriquez Palacios, Miriam Mecha, Ana Feliu, Ainoa Rueda-Zubiaurre, Alba Angelina, Leticia Martin-Cruz, Mar Martín-Fontecha, Oscar Palomares, Carmen Guaza, Eduardo Peña-Cabrera, María L López-Rodríguez, Silvia Ortega-Gutierrez
Serotonin (5-HT) modulates key aspects of the immune system. However, its precise function and the receptors involved in the observed effects have remained elusive. Among the different serotonin receptors, 5-HT1A plays an important role in the immune system given its presence in cells involved in both the innate and the adaptive immune responses, but its actual levels of expression under different conditions have not been comprehensively studied due to the lack of suitable tools. To further clarify the role of 5-HT1A receptor in the immune system, we have developed a fluorescent small molecule probe that enables the direct study of the receptor levels in native cells...
May 7, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29731439/inhibition-of-diet-restriction-induced-behavioral-deficits-by-tryptophan-administration-in-rats
#17
Darakhshan M Saleem, Shafaque Mehboob, Moona Mehboob Khan, Noreen Samad, Afshan Zafar, Darakhshan J Haleem
Diet has a great impact on brain health and function. It plays an important role to improve and control a number of psychiatric disorders such as depression, anxiety, hyperactivity and behavioral impulsivity. Anorexia Nervosa (AN) is one of the psychiatric disorder which is associated with diet. In AN, patients show extreme dieting, weight loss, hyperactivity, depression/anxiety, self-control and behavioral impulsivity. Previous studies showed that during diet restriction, tryptophan decreases serotonin (5-hydroxytryptamine; 5-HT) metabolism in the brain due to its less availability and contributes psychiatric problems associated with AN...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29730825/-18-f-f13640-preclinical-evaluation-in-rodent-cat-and-primate-as-a-5-ht-1a-receptor-agonist-for-pet-neuroimaging
#18
Benjamin Vidal, Sylvain Fieux, Matthieu Colom, Thierry Billard, Caroline Bouillot, Olivier Barret, Cristian Constantinescu, Gilles Tamagnan, Adrian Newman-Tancredi, Luc Zimmer
Serotonin 1A receptors are known to play an important role in many psychiatric and neurodegenerative disorders. Currently, all available 5-HT1A receptor PET radiopharmaceuticals that are radiolabeled with fluorine-18 are antagonists. As agonists bind preferentially to the high-affinity state of receptors, it would be of great interest to develop agonist radioligands which could provide a measure of the functional 5-HT1A receptors in pathophysiological processes. The 5-HT1A receptor agonist candidates we recently proposed had promising in vitro properties but were not optimal in terms of PET imaging...
May 5, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29730700/risk-seeking-for-losses-is-associated-with-5-httlpr-but-not-with-transient-changes-in-5-ht-levels
#19
Philipp T Neukam, Nils B Kroemer, Yacila I Deza Araujo, Lydia Hellrung, Shakoor Pooseh, Marcella Rietschel, Stephanie H Witt, Uwe Schwarzenbolz, Thomas Henle, Michael N Smolka
RATIONALE: Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making. OBJECTIVES: To test whether high 5-HT levels decrease loss aversion, risk-seeking for gains, and risk-seeking for losses. METHODS: In a first session, 611 participants were genotyped for 5-HTTLPR and performed a mixed gambles (MGA) task and two probability discounting tasks for gains and losses, respectively (PDG/PDL)...
May 5, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29723540/tnf%C3%AE-dependent-anhedonia-and-upregulation-of-hippocampal-serotonin-transporter-activity-in-a-mouse-model-of-collagen-induced-arthritis
#20
Eric Brown, Conor J Mc Veigh, Leilani Santos, Martina Gogarty, Heidi Kaastrup Müller, Betina Elfving, David J Brayden, Jana Haase
The serotonin transporter (SERT) facilitates high affinity reuptake of 5-HT from the extracellular fluid and dysregulation of transporter function has been implicated in a range of mood disorders including depression. Recent studies have linked immune system activation to depression as well as to altered serotonin transporter activity. Advancing previous studies, which have mainly focussed on acute effects of immune system activation, in this study we used collagen-induced arthritis (CIA) in mice as a model of chronic inflammatory disease, to investigate the effect of prolonged inflammation on brain SERT function and behaviour...
April 30, 2018: Neuropharmacology
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