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https://www.readbyqxmd.com/read/27914088/murine-mycobacterium-marinum-infection-as-a-model-for-tuberculosis
#1
Julia Lienard, Fredric Carlsson
Mycobacteria are a major human health problem globally. Regarding tuberculosis the situation is worsened by the poor efficacy of current vaccine regimens and by emergence of drug-resistant strains (Manjelievskaia J et al, Trans R Soc Trop Med Hyg 110: 110, 2016; Pereira et al., Lancet Infect Dis 12:300-306, 2012; http://www.who.int/tb/publications/global_report/en/) undermining both disease-prevention and available treatments. Thus, increased basic understanding of mycobacterial-and particularly Mycobacterium tuberculosis-virulence strategies and pathogenesis is of great importance...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27911953/correction-environmental-nontuberculous-mycobacteria-in-the-hawaiian-islands
#2
Jennifer R Honda, Nabeeh A Hasan, Rebecca M Davidson, Myra D Williams, L Elaine Epperson, Paul R Reynolds, Terry Smith, Elena Iakhiaeva, Matthew J Bankowski, Richard J Wallace, Edward D Chan, Joseph O Falkinham, Michael Strong
[This corrects the article DOI: 10.1371/journal.pntd.0005068.].
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27911922/nucleic-acid-amplification-testing-and-sequencing-combined-with-acid-fast-staining-in-needle-biopsy-lung-tissues-for-the-diagnosis-of-smear-negative-pulmonary-tuberculosis
#3
Faming Jiang, Weiwei Huang, Ye Wang, Panwen Tian, Xuerong Chen, Zongan Liang
BACKGROUND: Smear-negative pulmonary tuberculosis (PTB) is common and difficult to diagnose. In this study, we investigated the diagnostic value of nucleic acid amplification testing and sequencing combined with acid-fast bacteria (AFB) staining of needle biopsy lung tissues for patients with suspected smear-negative PTB. METHODS: Patients with suspected smear-negative PTB who underwent percutaneous transthoracic needle biopsy between May 1, 2012, and June 30, 2015, were enrolled in this retrospective study...
2016: PloS One
https://www.readbyqxmd.com/read/27911152/non-tuberculous-mycobacterial-bloodstream-infections-in-patients-with-indwelling-vascular-catheters-the-role-of-sickle-cell-anaemia
#4
Babatunde Edun, Ansal Shah, Martin Durkin, Melanie Whitmire, Shanetta Patterson Williams, Helmut Albrecht, Majdi Al-Hasan, Sharon Weissman
INTRODUCTION: Few studies have examined risk factors for nontuberculous mycobacteria (NTM) bloodstream infections (BSI) involving indwelling vascular catheters (IDVC). Sickle cell anaemia (HbSS/SC) is known to affect several aspects of the immune system leading to relative immune deficiency. The purpose of this retrospective nested case-control study was to determine if HbSS/SC is a risk factor for NTM BSI among individuals with IDVCs. METHODS: All NTM IDVC infections (cases) at two tertiary hospitals from 2008 to 2014 were reviewed...
December 2, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27909634/nontuberculous-mycobacteria-lymphadenitis-a-case-report
#5
Amanda M Krantz, Meera Varnam, Cristina Fernandez
Atypical mycobacteria, also known as nontuberculous mycobacteria (NTM) includes acid-fast bacteria other than Mycobacterium tuberculosis. NTM can be isolated from a variety of environmental sources including water, food products, domestic animals, and soil; human exposure is typically from soil to the oral cavity and respiratory tract. Diagnosis of NTM is suspected in children less than five years old with subacute, unilateral, non-tender cervicofacial lymphadenitis in combination with a history of water exposure, penetrating injection, as well as negative routine cultures or response to antistaphylococcal and antistreptococcal antibiotics...
October 25, 2016: Curēus
https://www.readbyqxmd.com/read/27904603/prevalence-of-nontuberculous-mycobacteria-isolated-from-environmental-samples-in-iran-a-meta-analysis
#6
REVIEW
Azad Khaledi, Abbas Bahador, Davood Esmaeili, Alireza Tafazoli, Kiarash Ghazvini, Davood Mansury
BACKGROUND: While the most nontuberculous mycobacteria (NTMs) species are considered as opportunistic pathogens, some of them are related to several human infections. It is believed that environment is the main source for these infections. Distribution and scattering pattern of NTMs has not been well studied in Iran and a few studies about this subject have been done, so the aim of this study was to determine prevalence of NTMs in environmental samples from Iran. MATERIALS AND METHODS: Data about prevalence of NTMs in environmental samples from Iran were obtained by searching databases...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27902860/genetic-and-biochemical-interactions-between-the-bacterial-replication-initiator-dnaa-and-the-nucleoid-associated-protein-rok-in-bacillus-subtilis
#7
Charlotte A Seid, Janet L Smith, Alan D Grossman
We identified interactions between the conserved bacterial replication initiator and transcription factor DnaA and the nucleoid-associated protein Rok of Bacillus subtilis. DnaA binds directly to clusters of DnaA boxes at the origin of replication and elsewhere, including the promoters of several DnaA-regulated genes. Rok, an analog of H-NS from gamma-proteobacteria that affects chromosome architecture and Lsr2 from Mycobacteria, binds A+T-rich sequences throughout the genome and represses expression of many genes...
November 30, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27902391/comparative-evaluation-of-the-advansure-mycobacteria-genoblot-assay-and-the-genotype-mycobacterium-cm-as-assay-for-the-identification-of-nontuberculous-mycobacteria
#8
Mina Yang, Hee Jae Huh, Hyeon Jeong Kwon, Ji-Youn Kim, Dong Joon Song, Won-Jung Koh, Chang-Seok Ki, Nam Yong Lee
In this study, to assess the performance of the AdvanSure Mycobacteria GenoBlot Assay (AdvanSure assay), we compared its performance with that of the GenoType Mycobacterium CM/AS assay (GenoType assay) for the identification of nontuberculous mycobacteria (NTM). Twenty-four reference strains and 103 consecutive clinical NTM isolates were analyzed. The accuracy rates for the 24 reference strains were 87.5% and 95.8% for the AdvanSure and GenoType assays respectively. For the 103 clinical isolates, a 91.3% (94/103) concordance rate was observed between the two assays...
October 24, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902313/streptomyces-caelicus-an-antibiotic-producing-species-of-the-genus-streptomyces-and-streptomyces-canchipurensis-li-et-al-2014-are-later-heterotypic-synonym-of-streptomyces-muensis-ningthoujam-et-al-2013
#9
Joachim Wink, Peter Schumann, Hans-Peter Klenk, Nestor Zaburannyi, Martin Westermann, Karin Martin, Stefanie P Glaeser, Peter Kämpfer, Ewelina Atasayar
"Streptomyces caelicus" DSM 40835T was first reported as the producer of the antibiotic griselimycin by some coworkers of Rhone Poulenc in 1971. The project on isolation of the antibiotic compound was stopped because of the bad solubility and selectivity of the compound towards Mycobacteria. At Sanofi-Aventis, Germany, the project was re-evaluated in 2007 and the gene cluster of griselimycin could be identified, characterized and was patented in 2013. At this time, "S. caelicus" was an invalid name. During the strain characterization work it was found, that S...
October 26, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27900974/disseminated-mycobacteria-chelonae-infection-in-a-kidney-pancreas-transplant-recipient-a-case-report-and-review-of-the-literature
#10
Shafi Malik, Ananda Ghosh, Shahid Husain
A 40-year-old male with a long-standing history of type 1 diabetes with end-stage renal failure underwent combined kidney-pancreas (KP) transplant from a standard criteria donor. Post-operative course was uncomplicated with good primary function of both transplant grafts. Induction was with thymoglobulin and maintenance immunosuppression was with tacrolimus, mycophenolate mofetil and prednisolone. Nine weeks post-transplant, the patient developed dysfunction of both grafts. Panel reactive antibody testing revealed that the patient had developed a de novo donor-specific antibody and considering an antibody-mediated rejection the patient was treated with intravenous pulse methyl prednisone 500 mg ×3 doses, IV immunoglobulin 2 mg/kg in two divided doses, and ATG 7 mg/kg (total dose of 700 mg)...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27899559/division-of-labor-among-mycobacterium-smegmatis-rnase-h-enzymes-rnase-h1-activity-of-rnha-or-rnhc-is-essential-for-growth-whereas-rnhb-and-rnha-guard-against-killing-by-hydrogen-peroxide-in-stationary-phase
#11
Richa Gupta, Debashree Chatterjee, Michael S Glickman, Stewart Shuman
RNase H enzymes sense the presence of ribonucleotides in the genome and initiate their removal by incising the ribonucleotide-containing strand of an RNA:DNA hybrid. Mycobacterium smegmatis encodes four RNase H enzymes: RnhA, RnhB, RnhC and RnhD. Here, we interrogate the biochemical activity and nucleic acid substrate specificity of RnhA. We report that RnhA (like RnhC characterized previously) is an RNase H1-type magnesium-dependent endonuclease with stringent specificity for RNA:DNA hybrid duplexes. Whereas RnhA does not incise an embedded mono-ribonucleotide, it can efficiently cleave within tracts of four or more ribonucleotides in duplex DNA...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27894646/the-enigmatic-esx-proteins-looking-beyond-mycobacteria
#12
REVIEW
Meera Unnikrishnan, Chrystala Constantinidou, Tracy Palmer, Mark J Pallen
Bacteria export proteins across membranes using a range of transport machineries. Type VII secretion systems (T7SSs), originally described in mycobacteria, are now known to be widespread across diverse bacterial phyla. Recent studies have characterized secretion components and mechanisms of type VII secretion in pathogenic and environmental bacteria. A variety of functions have been attributed to T7SS substrates, including interactions with eukaryotes and with other bacteria. Here, we evaluate the growing body of knowledge on T7SSs, with focus on the nonmycobacterial systems, reviewing their phylogenetic distribution, structure and function in diverse settings...
November 25, 2016: Trends in Microbiology
https://www.readbyqxmd.com/read/27894280/is-there-any-association-between-sarcoidosis-and-infectious-agents-a-systematic-review-and-meta-analysis
#13
Tiago Esteves, Gloria Aparicio, Vicente Garcia-Patos
BACKGROUND: During the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. With the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. METHODS: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement from the Cochrane collaboration guidelines...
November 28, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27892873/evidence-of-disseminated-infection-by-mycobacterium-avium-subspecies-hominissuis-in-a-pet-ferret-mustela-putorius-furo
#14
Javier Bezos, Beatriz Álvarez-Carrión, Antonio Rodríguez-Bertos, Álvaro Fernández-Manzano, Lucía de Juan, Cristina Huguet, Víctor Briones, Beatriz Romero
The infection caused by the zoonotic opportunistic pathogen Mycobacterium avium subsp. hominissuis (Mah) was reported for the first time in a pet ferret. Both owners were HIV-positive. Euthanasia of the pet was recommended due to medical reasons and as a preventive action. Disseminated and open tuberculosis lesions were observed in the gastrointestinal and respiratory systems of the ferret. Ecographic and radiographic surveys showed a severe generalized lymphadenopathy, strong thickening of the gastric wall and peritoneum layer...
September 17, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27892398/therapy-resistant-septic-olecranon-bursitis-due-to-mycobacterium-gordonae
#15
Christian Konrads, Kilian Rückl, Mohammed El Tabbakh, Maximilian Rudert, Stefan Kircher, Piet Plumhoff
INTRODUCTION: Septic olecranon bursitis due to atypical mycobacteria is rare. An insidious beginning can delay diagnosis and treatment. Antibacterial therapy recommendations are not well-defined for bursitis caused by atypical mycobacteria. We present a rare case of olecranon bursitis caused by Mycobacterium gordonae, reporting our experiences regarding pathogen identification and antibiotic therapy, which differs from regimes used in common septic bursitis mostly caused by staphylococcus aureus...
2016: SICOT-J
https://www.readbyqxmd.com/read/27890172/opportunistic-infections-in-biological-therapy-risk-and-prevention
#16
REVIEW
Paul A Bryant, John W Baddley
Patients being treated with biological therapies are at increased risk for serious infections, including opportunistic infections. Although more is known about opportunistic infection risk with older biologics, such as antitumor necrosis factor drugs, there is less knowledge of opportunistic infection risk with newer biological therapies. The incidence of certain opportunistic infections (tuberculosis, herpes zoster, pneumocystosis) has been rigorously evaluated in large observational studies. However, data are more limited for other infections (histoplasmosis, nontuberculous mycobacteria)...
February 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27889398/recognition-of-mycobacterial-lipids-by-immune-receptors
#17
REVIEW
Eri Ishikawa, Daiki Mori, Sho Yamasaki
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), infects one-third of the world's population and causes 1.5 million deaths each year. The cell envelopes of mycobacteria comprise a wealth of unique glycolipids, including trehalose-6,6'-dimycolate (TDM), lipoarabinomannan (LAM), lipomannan (LM), and phosphatidylinositol (PI) mannosides (PIMs). These lipids are important modulators of the host immune responses during infection and in some cases have been used as adjuvants [e.g., complete Freund's adjuvant (CFA)]...
November 23, 2016: Trends in Immunology
https://www.readbyqxmd.com/read/27889251/modified-protocol-for-drug-susceptibility-testing-of-mgit-cultures-of-mycobacterium-tuberculosis-by-the-mgit-960
#18
Aline Gois Adami, Juliana Failde Gallo, Juliana Maira Watanabe Pinhata, Maria Conceição Martins, Carmen Maria Saraiva Giampaglia, Rosangela Siqueira de Oliveira
A rapid detection of resistance in Mycobacterium tuberculosis is crucial for management and control of tuberculosis. This study evaluated a more rapid and cost-effective drug susceptibility testing (DST) protocol using primary isolates of M. tuberculosis in mycobacteria growth indicator tube (MGIT). Ninety-four M. tuberculosis isolates in MGIT were subjected to DST by the manufacturer's method, i.e., primary isolates were subcultured and DST was performed from positive cultures for a maximum of 5days; and by our modified method, i...
October 30, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27888674/qpcr-detection-of-mycobacterium-leprae-in-biopsies-and-slit-skin-smear-of-different-leprosy-clinical-forms
#19
Michelle de Campos Soriani Azevedo, Natália Mortari Ramuno, Luciana Raquel Vincenzi Fachin, Mônica Tassa, Patrícia Sammarco Rosa, Andrea de Faria Fernandes Belone, Suzana Madeira Diório, Cleverson Teixeira Soares, Gustavo Pompermaier Garlet, Ana Paula Favaro Trombone
Leprosy, whose etiological agent is Mycobacterium leprae, is a chronic infectious disease that mainly affects the skin and peripheral nervous system. The diagnosis of leprosy is based on clinical evaluation, whereas histopathological analysis and bacilloscopy are complementary diagnostic tools. Quantitative PCR (qPCR), a current useful tool for diagnosis of infectious diseases, has been used to detect several pathogens including Mycobacterium leprae. The validation of this technique in a robust set of samples comprising the different clinical forms of leprosy is still necessary...
November 23, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27888200/effect-of-principal-component-analysis-centering-and-scaling-on-classification-of-mycobacteria-from-raman-spectra
#20
Cynthia Hanson, Michael Sieverts, Elizabeth Vargis
Raman spectroscopy has been used for decades to detect and identify biological substances as it provides specific molecular information. Spectra collected from biological samples are often complex, requiring the aid of data truncation techniques such as principal component analysis (PCA) and multivariate classification methods. Classification results depend on the proper selection of principal components (PCs) and how PCA is performed (scaling and/or centering). There are also guidelines for choosing the optimal number of PCs such as a scree plot, Kaiser criterion, or cumulative percent variance...
November 25, 2016: Applied Spectroscopy
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