Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Luca Arcaini, Côme Bommier, Juan Pablo Alderuccio, Michele Merli, Nicole Fabbri, Maria Elena Nizzoli, Matthew J Maurer, Vittoria Tarantino, Simone Ferrero, Sara Rattotti, Annalisa Talami, Roberta Murru, Arushi Khurana, Raphael Mwangi, Marina Deodato, Emanuele Cencini, Francesca Re, Carlo Visco, Andrew L Feldman, Brian K Link, Marcia Torresan Delamain, Michele Spina, Ombretta Annibali, Alessandro Pulsoni, Andrés J M Ferreri, Caterina Cecilia Stelitano, Elsa Pennese, Thomas M Habermann, Luigi Marcheselli, Sunwoo Han, Isildinha M Reis, Marco Paulli, Izidore S Lossos, James R Cerhan, Stefano Luminari
BACKGROUND: Marginal zone lymphomas (MZL), comprised of three unique but related subtypes, lack a unifying prognostic score applicable to all the patients in need for systemic chemotherapy and/or immunotherapy. METHODS: Patients from the prospective NF10 study (NCT02904577) with newly diagnosed MZL and receiving frontline systemic therapy at diagnosis or after observation were used to train a prognostic model. The primary endpoint was progression-free survival (PFS) from start of treatment...
June 2024: EClinicalMedicine
#2
JOURNAL ARTICLE
Wenyue Ma, Hongjie Gao, Mengmeng Chang, Zhiyi Lu, Ding Li, Chen Ding, Dan Bi, Fengyin Sun
OBJECTIVE: This study was conducted to explore the risk factors for the prognosis and recurrence of ureteropelvic junction obstruction (UPJO). METHODS: The correlation of these variables with the prognosis and recurrence risks was analyzed by binary and multivariate logistic regression. Besides, a nomogram was constructed based on the multivariate logistic regression calculation. After the model was verified by the C-statistic, the ROC curve was plotted to evaluate the sensitivity of the model...
2024: Frontiers in Pediatrics
#3
Kai Zhai, Kai Zheng, Ming Xu, Zhe-Ming Bao, Zi-Wei Hou, Xiu-Chun Yu
BACKGROUND: Revision of tumor-type prosthetic fractures is very challenging in clinical work. Traditional repair methods may not be able to meet the needs of complex cases or cause greater bone damage. Therefore, more effective and reliable solutions need to be found. CASE PRESENTATION: This study presents a novel revision technique for managing fractures of tumor-type total elbow prostheses. A 57-year-old female patient was diagnosed with a left distal humeral bone tumor accompanied by pathological fracture and underwent customized tumor-type total elbow prosthesis arthroplasty...
April 17, 2024: Orthopaedic Surgery
#4
JOURNAL ARTICLE
Rebecca R Valentino, William J Scotton, Shanu F Roemer, Tammaryn Lashley, Michael G Heckman, Maryam Shoai, Alejandro Martinez-Carrasco, Nicole Tamvaka, Ronald L Walton, Matthew C Baker, Hannah L Macpherson, Raquel Real, Alexandra I Soto-Beasley, Kin Mok, Tamas Revesz, Elizabeth A Christopher, Michael DeTure, William W Seeley, Edward B Lee, Matthew P Frosch, Laura Molina-Porcel, Tamar Gefen, Javier Redding-Ochoa, Bernardino Ghetti, Andrew C Robinson, Christopher Kobylecki, James B Rowe, Thomas G Beach, Andrew F Teich, Julia L Keith, Istvan Bodi, Glenda M Halliday, Marla Gearing, Thomas Arzberger, Christopher M Morris, Charles L White, Naguib Mechawar, Susana Boluda, Ian R MacKenzie, Catriona McLean, Matthew D Cykowski, Shih-Hsiu J Wang, Caroline Graff, Rashed M Nagra, Gabor G Kovacs, Giorgio Giaccone, Manuela Neumann, Lee-Cyn Ang, Agostinho Carvalho, Huw R Morris, Rosa Rademakers, John A Hardy, Dennis W Dickson, Jonathan D Rohrer, Owen A Ross
BACKGROUND: Pick's disease is a rare and predominantly sporadic form of frontotemporal dementia that is classified as a primary tauopathy. Pick's disease is pathologically defined by the presence in the frontal and temporal lobes of Pick bodies, composed of hyperphosphorylated, three-repeat tau protein, encoded by the MAPT gene. MAPT has two distinct haplotypes, H1 and H2; the MAPT H1 haplotype is the major genetic risk factor for four-repeat tauopathies (eg, progressive supranuclear palsy and corticobasal degeneration), and the MAPT H2 haplotype is protective for these disorders...
May 2024: Lancet Neurology
#5
JOURNAL ARTICLE
Melinda L Hsu, Mary C Boulanger, Sarah Olson, Cyd Eaton, Laura Prichett, Matthew Guo, Mattea Miller, Julie Brahmer, Patrick M Forde, Kristen A Marrone, Michelle Turner, Josephine L Feliciano
IMPORTANCE: Despite a growing population of survivors of lung cancer, there is limited understanding of the survivorship journey. Survivors of lung cancer experience unmet physical, social, emotional, and medical needs regardless of stage at diagnosis or treatment modalities. OBJECTIVE: To investigate the association of unmet needs with quality of life (QOL) and financial toxicity (FT) among survivors of lung cancer. DESIGN, SETTING, AND PARTICIPANTS: This survey study was conducted at Johns Hopkins Sidney Kimmel Comprehensive Cancer Center thoracic oncology clinics between December 1, 2020, and September 30, 2021, to assess needs (physical, social, emotional, and medical), QOL, and FT among survivors of lung cancer...
April 1, 2024: JAMA Network Open
#6
JOURNAL ARTICLE
Chen Chen, Jianyu Zhang, Renwei Cao, Kehan Hua, Yejun Zha, Maoqi Gong, Xieyuan Jiang
BACKGROUND: Tension band wiring and plate fixation are common internal fixation methods used for olecranon fractures, but complications and reoperations are common. The purpose of this study is to investigate the clinical outcomes of displaced olecranon fractures treated with olecranon sled internal fixation. METHODS: The data of 39 patients with olecranon fractures treated with olecranon sled in the Department of Traumatology of Beijing Jishuitan Hospital between May 2018 and April 2020 were retrospectively analyzed...
April 30, 2024: Heliyon
#7
JOURNAL ARTICLE
Nathaniel P Rogers, Christopher J Boes
A visiting surgeon described his disappointment with an aspect of the Mayo Clinic in 1914, stating that there was "the almost lack of anything that could be dignified by the term 'lecture.'" One year later, the Mayo Foundation for Medical Education and Research was founded. By 1917, the foundation declared history of medicine a graduate-level subject, and history of medicine questions were included in final oral examinations. In 1920 and 1921, lectures were given on historical topics; however, these lectures petered out, and there were no historical lectures in the official curriculum of 1923 or 1924...
2024: Proceedings of the Baylor University Medical Center
#8
JOURNAL ARTICLE
Jessica Wojciechowski, Arnab Mukherjee, Christopher Banfield, Timothy Nicholas
Ritlecitinib, an oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family inhibitor, was evaluated in patients with ulcerative colitis (UC) in a phase 2b trial. Model-informed drug development strategies were applied to bridge observations from phase 2b to predictions for a proposed phase 3 study design to assess the probability of achieving the target efficacy outcome. A longitudinal exposure-response model of the time course of the 4 Mayo subscores (rectal bleeding, stool frequency, physician's global assessment, and endoscopic subscore) in patients with UC receiving placebo or ritlecitinib was developed using population modeling approaches and an item response theory framework...
April 16, 2024: Clinical Pharmacology and Therapeutics
#9
JOURNAL ARTICLE
Mitchell Padkins, Kianoush Kashani, Meir Tabi, Ognjen Gajic, Jacob C Jentzer
BACKGROUND: An elevated shock index (SI) predicts worse outcomes in multiple clinical arenas. We aimed to determine whether the SI can aid in mortality risk stratification in unselected cardiac intensive care unit patients. METHODS: We included admissions to the Mayo Clinic from 2007 to 2015 and stratified them based on admission SI. The primary outcome was in-hospital mortality, and predictors of in-hospital mortality were analyzed using multivariable logistic regression...
2024: PloS One
#10
JOURNAL ARTICLE
Sarah Yurick, Soumya Ray, Sherif El-Nashar, Erin Brennand, Shunaha Kim-Fine, May Sanaee, Shauna Regan, Roxana Geoffrion, John Occhino, Adonis Hijaz, David Sheyn
INTRODUCTION AND HYPOTHESIS: The objective was to develop a prediction model for urinary tract infection (UTI) after pelvic surgery. METHODS: We utilized data from three tertiary care centers of women undergoing pelvic surgery. The primary outcome was a UTI within 8 weeks of surgery. Additional variables collected included procedural data, severity of prolapse, use of mesh, anti-incontinence surgery, EBL, diabetes, steroid use, estrogen use, postoperative catheter use, PVR, history of recurrent UTI, operative time, comorbidities, and postoperative morbidity including venous thromboembolism, surgical site infection...
April 16, 2024: International Urogynecology Journal
#11
JOURNAL ARTICLE
Anke L Nguyen, Claudia Brick, David Liu, David J Gibson, Peter R Gibson, Miles P Sparrow
BACKGROUND AND AIM: C-reactive protein (CRP)-to-albumin ratio (CAR) is a novel score with prognostic value in inflammatory conditions. This study assessed the performance of CAR as an objective marker of disease activity and prediction of subtherapeutic infliximab trough levels in patients with inflammatory bowel disease (IBD). METHODS: A retrospective study was conducted on three different patient cohorts with IBD: patients who had (i) fecal calprotectin (FC) measurements; (ii) Mayo Endoscopic Scores; and (iii) infliximab trough levels available...
April 2024: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
#12
JOURNAL ARTICLE
Yi-Fan Hu, Shun-Xin Li, Hong-Li Liu, Zhi-Xiang Du, Shuang-Shuang Wang, Miao-Yang Chen, Li Wang, Qing-Fang Xiong, Yan-Dan Zhong, Du-Xian Liu, Yong-Feng Yang
BACKGROUND/AIMS: : The histological characteristics and natural history of precirrhotic primary biliary cholangitis (PBC) with portal hypertension (PH) are unclear. Our aim was to clarify the prevalence, risk factors, and histological characteristics of precirrhotic PBC patients with PH. METHODS: : This retrospective study compared the clinical features, histological characteristics, and response to ursodeoxycholic acid (UDCA) between the PH and non-PH groups of precirrhotic PBC patients...
April 16, 2024: Gut and Liver
#13
JOURNAL ARTICLE
Soo Min Cha, Sang Hyun Lee, In Ho Ga, Yong Hwan Kim
BACKGROUND: We have attempted to restore the arc of motion by considering trochlear-coronoid articulation as a complete circle during fixation of the coronoid, even for comminuted coronoid fractures with partial loss of articular cartilage (CCFPLAC), using various kinds of locking plates. Herein, we report the radiological and clinical outcomes after fixation of the basal-1 type of CCFPLAC (O'Driscoll classification) using our method. METHODS: Thirty-one patients diagnosed with CCFPLAC were admitted between January 2012 and December 2020...
April 9, 2024: Injury
#14
JOURNAL ARTICLE
Zachary Oglesby, Alanna Nicole Rillorta, Cheydon Agos, Ku'uipo Borges, Saien Cabradilla, Michael Garvin, Bryn Higuchi, Elisabeth Kamaka, Chancen Law, Matthew Liu, Grace Matsumoto, Tiffany Ng, Gemma Quiroz, Chelsea Ramiro, Jamie Saito, Malia Williams, Asia Yamada, Zane Yogi, Sidney Olson, Soaleha Shams, Kelley Withy, Chris Pierret
The Ala Wai Canal is an artificial waterway in the tourist district of Waikiki in Honolulu, HI. Originally built to collect runoff from industrial, residential, and green spaces dedicated to recreation, the Ala Wai Canal has since experienced potent levels of toxicity due to this runoff entering the watershed and making it hazardous for both marine life and humans at current concentration, including Danio rerio (zebrafish). A community of learners at educations levels from high school to postbaccalaureate from Oahu, HI was connected through the Consortium for Increasing Research and Collaborative Learning Experiences (CIRCLE) distance research program...
April 2024: Zebrafish
#15
JOURNAL ARTICLE
Derk C F Klatte, Jason S Starr, Kristin E Clift, Heather D Hardway, Jeanin E van Hooft, Monique E van Leerdam, Thomas P Potjer, R John Presutti, Douglas L Riegert-Johnson, Michael B Wallace, Yan Bi
PURPOSE: Guidelines recommend germline genetic testing (GT) for patients with pancreatic ductal adenocarcinoma (PDAC). This study aims to evaluate the utilization and outcomes of multigene panel GT in patients with PDAC. METHODS: This retrospective, multisite study included patients with PDAC diagnosed between May 2018 and August 2020 at Mayo Clinic Arizona, Florida, and Minnesota. Discussion, uptake, and outcomes of GT were compared before (May 1, 2018-May 1, 2019) and after (August 1, 2019-August 1, 2020) the guideline update, accounting for a transition period...
April 15, 2024: JCO oncology practice
#16
JOURNAL ARTICLE
Meagan T Tran, Desireé Brionne Dillard, Rewan M Abdelwahab, Isra Abdulwadood, Sarah Y Wu, Olufunmilola Adeleye, Mira M Shoukry, Nadine H Alamy, Audrey M Elegbede, Mira T Keddis, Elizabeth M Valencia, Sarah J Atunah-Jay
PROBLEM: In the United States, physician bias is exhibited early in medical training and contributes to systemic inequities within the field of medicine. A lack of diversity, equity, inclusion, and antiracism (DEI-AR) content within medical curricula drives critical gaps in knowledge and deficiencies when preparing medical students to serve patients of diverse backgrounds. At the Mayo Clinic Alix School of Medicine (MCASOM), student-led curricular reviews between 2017 to 2018 and 2020 to 2021 revealed opportunities to improve DEI-AR content within preclinical courses...
April 12, 2024: Academic Medicine
#17
JOURNAL ARTICLE
Arthur Dumoulin, Matthieu Chivot, Emile Dobelle, Jean-Noël Argenson, Damien Lami
BACKGROUND: While double plate fixation is the gold standard treatment for distal humerus fractures in the general population, it is the source of many complications in the elderly. Total elbow arthroplasty (TEA) has been proposed as an alternative treatment, with satisfactory short-term functional outcomes. However, little is known about the longevity of the implant and the mid- and long-term complications of this procedure. MATERIALS AND METHODS: A total of 58 TEAs were performed in 57 patients with comminuted distal humerus fractures between September 2008 and September 2019...
April 12, 2024: Orthopaedics & Traumatology, Surgery & Research: OTSR
#18
JOURNAL ARTICLE
Amira Isaac, Marcel W Keddeas, Abeer A Abd Elhady, Sara M Khatab, Shimaa A Elgohary, Hosam S El Baz
Ulcerative colitis is a chronic immune-mediated inflammatory condition of large intestine that is frequently associated with inflammation of the rectum but often extends proximally to involve other areas of the colon. The ultimate target of therapy is complete healing in the form of clinical remission, complete endoscopic and histological healing, and transmural healing for which endoscopy is mandatory. Colonoscopy may not always be applicable due to possible complications in active ulcerative colitis. Therefore, non-invasive biomarkers are needed to avoid the disadvantageous complications of invasive diagnostic procedures...
April 2024: Egyptian Journal of Immunology
#19
JOURNAL ARTICLE
Carlos Alonso-Mayo, Graciela Kohls, Samuel Santos-Ribeiro, Sergio Reis Soares, Juan A Garcia-Velasco
RESEARCH QUESTION: Should ovulation be triggered in a modified natural cycle (mNC) with recombinant human chorionic gonadotrophin (rHCG) as soon as a mean follicle diameter of 17 mm is visible, or is more flexible planning possible? DESIGN: This multicentre, retrospective, observational study of 3087 single frozen blastocyst transfers in mNC was carried out between January 2020 and September 2022. The inclusion criteria included endometrial thickness ≥7 mm and serum progesterone <1...
December 17, 2023: Reproductive Biomedicine Online
#20
JOURNAL ARTICLE
Chuan Zhang, Fei Xiong Chen, Kun Ma, Jiang Tao Ma
BACKGROUND: Coronal shear fractures of the distal humerus are not only rare and prone to misdiagnosis, but their surgical treatment can be challenging. We aimed to investigate the feasibility of exposing distal humeral coronal shear fractures with a combined lateral approach that preserves the extensors and lateral ulnar collateral ligament (LUCL) and to analyze the clinical efficacy of open reduction and internal fixation (ORIF) in the treatment of these injuries. METHODS: We included 45 patients who sustained coronal shear fractures of the distal humerus with the lateral epicondyle intact and were treated with ORIF from January 2013 to August 2020...
April 10, 2024: Journal of Shoulder and Elbow Surgery
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
