Zeng Ye, Qiang Li, Yuheng Hu, Haifeng Hu, Junfeng Xu, Muzi Guo, Wuhu Zhang, Xin Lou, Yan Wang, Heli Gao, Desheng Jing, Guixiong Fan, Yi Qin, Yue Zhang, Xuemin Chen, Jie Chen, Xiaowu Xu, Xianjun Yu, Mingyang Liu, Shunrong Ji
Cancer-associated fibroblasts (CAFs) play an important role in a variety of cancers. However, the role of tumor stroma in nonfunctional pancreatic neuroendocrine tumors (NF-PanNETs) is often neglected. Profiling the heterogeneity of CAFs can reveal the causes of malignant phenotypes in NF-PanNETs. Here, we found that patients with high stromal proportion had poor prognosis, especially for that with infiltrating stroma (stroma and tumor cells that presented an infiltrative growth pattern and no regular boundary)...
March 2, 2024: Cancer Letters