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Spatial neglect

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https://www.readbyqxmd.com/read/29791600/unilateral-spatial-neglect-in-the-acute-phase-of-ischemic-stroke-can-predict-long-term-disability-and-functional-capacity
#1
Gustavo José Luvizutto, Augusta Fabiana Moliga, Gabriela Rizzo Soares Rizzatti, Marcelo Ortolani Fogaroli, Eduardo de Moura Neto, Hélio Rubens de Carvalho Nunes, Luiz Antônio de Lima Resende, Rodrigo Bazan
OBJECTIVE: The aim of this study was to assess the relationship between the degree of unilateral spatial neglect during the acute phase of stroke and long-term functional independence. METHODS: This was a prospective study of right ischemic stroke patients in which the independent variable was the degree of spatial neglect and the outcome that was measured was functional independence. The potential confounding factors included sex, age, stroke severity, topography of the lesion, risk factors, glycemia and the treatment received...
May 21, 2018: Clinics
https://www.readbyqxmd.com/read/29791146/effect-of-cholesterol-on-membrane-dipole-potential-atomistic-and-coarse-grained-molecular-dynamics-simulations
#2
Hujun Shen, Mingsen Deng, Zhenhua Wu, Jihua Zhang, Yachao Zhang, Chengui Gao, Chao Cen
The effect of cholesterol on membrane dipole potential has been the subject of a great number of experimental and theoretical investigations, but these studies have yielded different findings and interpretations at high cholesterol concentrations. This suggests that the underlying mechanism of the cholesterol effect is not well addressed. Moreover, as far as we know, none of the previously proposed coarse-grained (CG) models (including MARTINI and its improved versions) has been successfully used to probe the effect of cholesterol on membrane dipole potential, owing to either an inaccurate description of water-cholesterol electrostatics or the neglect of the contribution of cholesterol to membrane dipole potential...
May 23, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29787866/handedness-dependent-functional-organizational-patterns-within-the-bilateral-vestibular-cortical-network-revealed-by-fmri-connectivity-based-parcellation
#3
V Kirsch, R Boegle, D Keeser, E Kierig, B Ertl-Wagner, T Brandt, M Dieterich
Current evidence points towards a vestibular cortex that involves a multisensory bilateral temporo-parietal-insular network with a handedness-dependent hemispheric lateralization. This study aimed to identify handedness-dependent organizational patterns of (lateralized and non-lateralized) functional subunits within the human vestibular cortex areas. 60 healthy volunteers (30 left-handed and 30 right-handed) were examined on a 3T MR scanner using resting state functional MRI (fMRI). The data was analyzed in four major steps using a functional connectivity based parcellation (fCBP) approach: (1) independent component analysis (ICA) on a whole brain level to identify different resting state networks (RSN); (2) creation of a vestibular informed mask from four whole brain ICs that included reference coordinates of the vestibular network extracted from meta-analyses of vestibular neuroimaging experiments; (3) Re-ICA confined to the vestibular informed mask; (4) cross-correlation of the activated voxels within the vestibular subunits (parcels) to each other (P-to-P) and to the whole-brain RSN (P-to-RSN)...
May 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29782328/post-stroke-visual-neglect-affects-goal-directed-locomotion-in-different-perceptuo-cognitive-conditions-and-on-a-wide-visual-spectrum
#4
Tatiana Ogourtsova, Philippe S Archambault, Anouk Lamontagne
BACKGROUND: Unilateral spatial neglect (USN), a highly prevalent and disabling post-stroke deficit, has been shown to affect the recovery of locomotion. However, our current understanding of USN role in goal-directed locomotion control, and this, in different cognitive/perceptual conditions tapping into daily life demands, is limited. OBJECTIVES: To examine goal-directed locomotion abilities in individuals with and without post-stroke USN vs. healthy controls. METHODS: Participants (n = 45, n = 15 per group) performed goal-directed locomotion trials to actual, remembered and shifting targets located 7 m away at 0° and 15° right/left while immersed in a 3-D virtual environment...
2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29770543/impairment-in-toileting-behavior-after-a-stroke
#5
Eri Kawanabe, Makoto Suzuki, Satoshi Tanaka, Shotaro Sasaki, Toyohiro Hamaguchi
AIM: Dependence for toileting is the most problematic aspect for patients after a stroke. However, the relative difficulty of each component of toileting and the predictors for independent performance of these activities are unknown. We investigated these issues in stroke patients using Boltzmann sigmoid and generalized linear modeling. METHODS: We carried out a cross-sectional correlation study, including 107 adult inpatients, hospitalized for a stroke. We assessed the activity components of toileting, as well as evaluated physical impairment using the Fugl-Meyer Assessment, impairments in balance using the Berg Balance Scale, cognitive impairments using the Mini-Mental State Examination and the presence or absence of unilateral spatial neglect or aphasia...
May 17, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29770439/increase-of-frontal-neuronal-activity-in-chronic-neglect-after-training-in-virtual-reality
#6
U Ekman, H Fordell, J Eriksson, N Lenfeldt, A Wåhlin, A Eklund, J Malm
OBJECTIVES: A third of patients with stroke acquire spatial neglect associated with poor rehabilitation outcome. New effective rehabilitation interventions are needed. Scanning training combined with multisensory stimulation to enhance the rehabilitation effect is suggested. In accordance, we have designed a virtual-reality based scanning training that combines visual, audio and sensori-motor stimulation called RehAtt® . Effects were shown in behavioural tests and activity of daily living...
May 16, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29744565/different-patterns-of-confabulation-in-left-visuo-spatial-neglect
#7
Gianfranco Dalla Barba, Marta Brazzarola, Claudia Barbera, Sara Marangoni, Francesco Causin, Paolo Bartolomeo, Michel Thiebaut de Schotten
Confabulating patients produce statements and actions that are unintentionally incongruous to their history, background, present and future situation. Here we present the very unusual case of a patient with right hemisphere damage and signs of left visual neglect, who, when presented with visual stimuli, confabulated both for consciously undetected and for consciously detected left-sided details. Advanced anatomical investigation suggested a disconnection between the parietal and the temporal lobes in the right hemisphere...
May 9, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29740529/therapeutic-intervention-for-visuo-spatial-neglect-after-stroke-a-meta-analysis-of-randomized-controlled-trials
#8
Jae-Sung Kwon
Objectives: The aims of this meta-analysis were to examine intervention methods of qualitatively, well-designed studies from the past 10 years for treating visuo-spatial neglect (VSN) in patients who had suffered a stroke, and to evaluate the combined effects of intervention. Methods: Studies published between 2008 and 2017 on the theme of VSN were collected from PubMed, CINAHL, and MEDLINE, representative academic databases and search engines. The PEDro scale was used for evaluating the quality of methodology...
April 2018: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/29734636/a-novel-approach-to-assessing-environmental-disturbance-based-on-habitat-selection-by-zebra-fish-as-a-model-organism
#9
Cristiano V M Araújo, Daniel M Griffith, Victoria Vera-Vera, Paul Vargas Jentzsch, Laura Cervera, Beatriz Nieto-Ariza, David Salvatierra, Santiago Erazo, Rusbel Jaramillo, Luis A Ramos, Matilde Moreira-Santos, Rui Ribeiro
Aquatic ecotoxicity assays used to assess ecological risk assume that organisms living in a contaminated habitat are forcedly exposed to the contamination. This assumption neglects the ability of organisms to detect and avoid contamination by moving towards less disturbed habitats, as long as connectivity exists. In fluvial systems, many environmental parameters vary spatially and thus condition organisms' habitat selection. We assessed the preference of zebra fish (Danio rerio) when exposed to water samples from two western Ecuadorian rivers with apparently distinct disturbance levels: Pescadillo River (highly disturbed) and Oro River (moderately disturbed)...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29725815/classical-swine-fever-in-india-current-status-and-future-perspective
#10
REVIEW
Vinod Kumar Singh, Kaushal Kishore Rajak, Amit Kumar, Sharad Kumar Yadav
Classical swine fever (CSF) is a globally significant disease of swine caused by classical swine fever virus. The virus affects the wild boars and pigs of all age groups, leading to acute, chronic, late-onset or in-apparent course of the disease. The disease causes great economic loss to the piggery industry due to mortality, stunted growth, poor reproductive performance, and by impeding the international trade of pig and pig products. In India, CSF outbreaks are reported from most of the states wherever pig rearing is practiced and more frequently from northeast states...
May 4, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29722220/-the-impact-of-phylogenetic-uncertainty-on-the-metrics-of-community-phylogenetic-structure
#11
Jia Yao Cai, Yuan Yuan Ding, Xin Tong, Ren Ren Wang, Xiao Ling Gong, Xiao Yong Chen, Guo Chun Shen
Phylogeny has been widely used to quantify community phylogenetic structure and to infer the underlying mechanism. Many studies, however, neglected phylogeny uncertainty and its potential impact on community phylogenetic structure. In this study, we explored the potential impact of phylogenetic uncertainty among 150 species in a 20 hm2 plot in Tiantong, Zhejiang. One consensus tree and 999 phylogenetic trees representing the phylogenetic uncertainty were estimated based on two cpDNA fragments (rbcL and matK)...
March 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29720958/crossed-leg-sign-is-associated-with-severity-of-unilateral-spatial-neglect-after-stroke
#12
Gustavo José Luvizutto, Eduardo de Moura Neto, Luiz Antônio de Lima Resende, Hélio Rubens de Carvalho Nunes, Luiz Eduardo Gomes Garcia Betting, Rodrigo Bazan
Background: The crossed leg sign in patients with right hemisphere stroke is thought to be associated with perceptual disorders, such as unilateral spatial neglect (USN). The aim of this study was to compare the crossed leg sign with the severity of USN during the acute phase of stroke. Experimental procedures: This was an observational and prospective clinical study of individuals with a diagnosis of right parietal stroke, as confirmed by neuroimaging. The occurrence of the crossed leg sign, the time at which this occurred after the stroke, and a clinical diagnosis of USN were measured and recorded...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29720179/structural-patterns-of-selection-and-diversity-for-plasmodium-vivax-antigens-dbp-and-ama1
#13
Andrew J Guy, Vashti Irani, Jack S Richards, Paul A Ramsland
BACKGROUND: Plasmodium vivax is a significant contributor to the global malaria burden, and a vaccine targeting vivax malaria is urgently needed. An understanding of the targets of functional immune responses during the course of natural infection will aid in the development of a vaccine. Antibodies play a key role in this process, with responses against particular epitopes leading to immune selection pressure on these epitopes. A number of techniques exist to estimate levels of immune selection pressure on particular epitopes, with a sliding window analysis often used to determine particular regions likely to be under immune pressure...
May 2, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29719705/quantification-of-photoinduced-bending-of-dynamic-molecular-crystals-from-macroscopic-strain-to-kinetic-constants-and-activation-energies
#14
Stanislav Chizhik, Anatoly Sidelnikov, Boris Zakharov, Panče Naumov, Elena Boldyreva
Photomechanically reconfigurable elastic single crystals are the key elements for contactless, timely controllable and spatially resolved transduction of light into work from the nanoscale to the macroscale. The deformation in such single-crystal actuators is observed and usually attributed to anisotropy in their structure induced by the external stimulus. Yet, the actual intrinsic and external factors that affect the mechanical response remain poorly understood, and the lack of rigorous models stands as the main impediment towards benchmarking of these materials against each other and with much better developed soft actuators based on polymers, liquid crystals and elastomers...
February 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29710636/spatial-pattern-of-urban-change-in-two-chinese-megaregions-contrasting-responses-to-national-policy-and-economic-mode
#15
Wenjuan Yu, Weiqi Zhou
Spatial pattern of urban change reflects the urbanization process. Previously, studies on the change of city more focused on the large cities and neglected the urban megaregion growth processes that may include changes in smaller cities. In this study, we investigated the spatial pattern of urban change in the megaregion development process. In addition, we discussed the megaregion responses to the national policy and economic growth mode. We chose the Beijing-Tianjin-Hebei (BTH) and Yangtze River Delta (YRD) urban megaregions as our study areas and comparatively quantified the urban expansion and change based on developed land at both the regional and city scales during 1984-2010...
April 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29710021/-right-parietal-cerebral-infarction-with-symptoms-challenging-to-differentiate-between-alien-hand-sign-and-sensory-ataxia-a-case-report
#16
Takamichi Kanbayashi, Yudai Uchida, Keiichi Hokkoku, Masahiro Sonoo
We report the case of a 73-year-old right-handed female with a right parietal cerebral infarction and presented symptoms that were challenging to differentiate between alien hand sign (AHS) and sensory ataxia. She presented to our emergency department with chief complaints of abnormal involuntary movements and a feeling of foreignness on her left upper limb. The first neurological examination revealed left spatial neglect, left-side sensory impairment that included superficial and deep sensations, left limb-kinetic apraxia, and left limb ataxia...
April 28, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29703446/adding-methylphenidate-to-prism-adaptation-improves-outcome-in-neglect-patients-a-randomized-clinical-trial
#17
Jacques Luauté, Laurent Villeneuve, Adeline Roux, Stuart Nash, Jean-Yves Bar, Eric Chabanat, François Cotton, Sophie Ciancia, Pierre-Olivier Sancho, Patrick Hovantruc, François Quelard, Thierry Sarraf, Yann Cojan, Fadila Hadj-Bouziane, Alessandro Farné, Audrey Janoly-Dumenil, Dominique Boisson, Sophie Jacquin-Courtois, Gilles Rode, Yves Rossetti
Spatial neglect is one of the main predictors of poor functional recovery after stroke. Many therapeutic interventions have been developed to alleviate this condition, but to date the evidence of their effectiveness is still scarce. OBJECTIVE: The purpose of this study was to test whether combining prism adaptation (PA) and methylphenidate (MP) could enhance the recovery of neglect patients at a functional level. METHODS: RITAPRISM is a multicentre, randomized, double-blind, placebo-controlled study comparing PA plus placebo (control) versus PA plus MP...
April 4, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29686235/tritrophic-phenological-match-mismatch-in-space-and-time
#18
Malcolm D Burgess, Ken W Smith, Karl L Evans, Dave Leech, James W Pearce-Higgins, Claire J Branston, Kevin Briggs, John R Clark, Chris R du Feu, Kate Lewthwaite, Ruedi G Nager, Ben C Sheldon, Jeremy A Smith, Robin C Whytock, Stephen G Willis, Albert B Phillimore
Increasing temperatures associated with climate change may generate phenological mismatches that disrupt previously synchronous trophic interactions. Most work on mismatch has focused on temporal trends, whereas spatial variation in the degree of trophic synchrony has largely been neglected, even though the degree to which mismatch varies in space has implications for meso-scale population dynamics and evolution. Here we quantify latitudinal trends in phenological mismatch, using phenological data on an oak-caterpillar-bird system from across the UK...
April 23, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29685145/post-stroke-unilateral-spatial-neglect-virtual-reality-based-navigation-and-detection-tasks-reveal-lateralized-and-non-lateralized-deficits-in-tasks-of-varying-perceptual-and-cognitive-demands
#19
Tatiana Ogourtsova, Philippe S Archambault, Anouk Lamontagne
BACKGROUND: Unilateral spatial neglect (USN), a highly prevalent and disabling post-stroke impairment, has been shown to affect the recovery of locomotor and navigation skills needed for community mobility. We recently found that USN alters goal-directed locomotion in conditions of different cognitive/perceptual demands. However, sensorimotor post-stroke dysfunction (e.g. decreased walking speed) could have influenced the results. Analogous to a previously used goal-directed locomotor paradigm, a seated, joystick-driven navigation experiment, minimizing locomotor demands, was employed in individuals with and without post-stroke USN (USN+ and USN-, respectively) and healthy controls (HC)...
April 23, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29684009/switchable-slow-cellular-conductances-determine-robustness-and-tunability-of-network-states
#20
Guillaume Drion, Julie Dethier, Alessio Franci, Rodolphe Sepulchre
Neuronal information processing is regulated by fast and localized fluctuations of brain states. Brain states reliably switch between distinct spatiotemporal signatures at a network scale even though they are composed of heterogeneous and variable rhythms at a cellular scale. We investigated the mechanisms of this network control in a conductance-based population model that reliably switches between active and oscillatory mean-fields. Robust control of the mean-field properties relies critically on a switchable negative intrinsic conductance at the cellular level...
April 23, 2018: PLoS Computational Biology
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