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Muc5ac cancer

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https://www.readbyqxmd.com/read/27846863/prognostic-significance-of-mucin-expression-profiles-in-breast-carcinoma-with-signet-ring-cells-a-clinicopathological-study
#1
Ryuji Ohashi, Ayako Hayama, Keiko Yanagihara, Koji Yamashita, Takashi Sakatani, Hiroyuki Takei, Zenya Naito
BACKGROUND: Signet ring cells (SRCs) often accompany gastrointestinal carcinoma, referred to as SRC carcinoma; however, breast cancers containing SRCs have not been well characterized, leaving the prognostic significance of SRCs undetermined. We have described clinicopathological characteristics of patients with breast cancer containing SRCs in relation to the expression levels of MUC1, MUC2, MUC4, MUC5AC, and MUC6. METHODS: Twenty-two breast cancer cases with variable degrees of SRC population were retrospectively studied...
November 15, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27845339/a-combination-of-muc5ac-and-ca19-9-improves-the-diagnosis-of-pancreatic-cancer-a-multicenter-study
#2
Sukhwinder Kaur, Lynette M Smith, Asish Patel, Melanie Menning, Duncan C Watley, Saad S Malik, Shiv Ram Krishn, Kavita Mallya, Abhijit Aithal, Aaron R Sasson, Sonny L Johansson, Maneesh Jain, Shailender Singh, Sushovan Guha, Chandrakanth Are, Massimo Raimondo, Michael A Hollingsworth, Randall E Brand, Surinder K Batra
OBJECTIVES: Pancreatic cancer (PC) is a lethal malignancy that lacks specific diagnostic markers. The present study explores the diagnostic potential of the most differentially overexpressed secretory mucin MUC5AC alone and in combination with CA19-9 using multi-center training and validation sets. METHODS: The expression of MUC5AC in benign pancreatic pathologies, PC precursor lesions, primary PC tissues and metastatic lesions was evaluated by immunohistochemistry...
November 15, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27809484/characterizing-protein-glycosylation-through-on-chip-glycan-modification-and-probing
#3
Bryan S Reatini, Elliot Ensink, Brian Liau, Jessica Y Sinha, Thomas W Powers, Katie Partyka, Marshall Bern, Randall E Brand, Pauline Mary Rudd, Doron Kletter, Richard R Drake, Brian B Haab
Glycans are critical to protein biology and are useful as disease biomarkers. Many studies of glycans rely on clinical specimens, but the low amount of sample available for some specimens limits the experimental options. Here we present a method to obtain information about protein glycosylation using a minimal amount of protein. We treat proteins that were captured or directly spotted in small microarrays (2.2 x 2.2 mm) with exoglycosidases to successively expose underlying features, and then we probe the native or exposed features using a panel of lectins or glycan-binding reagents...
November 3, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27739441/non-ampullary-duodenal-carcinomas-clinicopathologic-analysis-of-47-cases-and-comparison-with-ampullary-and-pancreatic-adenocarcinomas
#4
Yue Xue, Alessandro Vanoli, Serdar Balci, Michelle M Reid, Burcu Saka, Pelin Bagci, Bahar Memis, Hyejeong Choi, Nobuyike Ohike, Takuma Tajiri, Takashi Muraki, Brian Quigley, Bassel F El-Rayes, Walid Shaib, David Kooby, Juan Sarmiento, Shishir K Maithel, Jessica H Knight, Michael Goodman, Alyssa M Krasinskas, Volkan Adsay
Literature on non-ampullary-duodenal carcinomas is limited. We analyzed 47 resected non-ampullary-duodenal carcinomas. Histologically, 78% were tubular-type adenocarcinomas mostly gastro-pancreatobiliary type and only 19% pure intestinal. Immunohistochemistry (n=38) revealed commonness of 'gastro-pancreatobiliary markers' (CK7 55, MUC1 50, MUC5AC 50, and MUC6 34%), whereas 'intestinal markers' were relatively less common (MUC2 36, CK20 42, and CDX2 44%). Squamous and mucinous differentiation were rare (in five each); previously, unrecognized adenocarcinoma patterns were noted (three microcystic/vacuolated, two cribriform, one of comedo-like, oncocytic papillary, and goblet-cell-carcinoid-like)...
October 14, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27705923/mucins-and-associated-o-glycans-based-immunoprofile-for-stratification-of-colorectal-polyps-clinical-implication-for-improved-colon-surveillance
#5
Shiv Ram Krishn, Sukhwinder Kaur, Yuri M Sheinin, Lynette M Smith, Shailendra K Gautam, Asish Patel, Maneesh Jain, Vasthala Juvvigunta, Priya Pai, Audrey J Lazenby, Hemant K Roy, Surinder K Batra
Sessile serrated adenoma/polyps (SSA/P) are premalignant lesions of colorectal cancer that are difficult to distinguish histologically from hyperplastic polyps (HP) of minimal to no malignant potential. Specific markers for differentiating SSA/P from HP can aid clinicians for optimizing colon surveillance intervals. The present study investigates the potential of mucins and associated O-glycans to distinguish SSA/P from HP. Expression of colonic mucins (MUC1, MUC4, MUC17, MUC2, and MUC5AC) and O-glycans [Sialyl LewisA (CA19-9) and Tn/Sialyl-Tn on MUC1] were analyzed in HP (n=33), SSA/P (n=39), and tubular adenoma (TA) (n=36) samples by immunohistochemistry...
September 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27670082/identification-of-stem-cells-in-the-epithelium-of-the-stomach-corpus-and-antrum-of-mice
#6
Junichi Matsuo, Shunichi Kimura, Akihiro Yamamura, Cai Ping Koh, Md Zakir Hossain, Dede Liana Heng, Kazuyoshi Kohu, Dominic Chih-Cheng Voon, Hiroshi Hiai, Michiaki Unno, Jimmy Bok Yan So, Feng Zhu, Supriya Srivastava, Meng Teh, Khay Guan Yeoh, Motomi Osato, Yoshiaki Ito
BACKGROUND & AIMS: Little is known about the mechanisms of gastric carcinogenesis, partly because it has been a challenge to identify characterize gastric stem cells. Runx genes regulate development and their products are transcription factors associated with cancer development. A Runx1 enhancer element, eR1, is a marker of hematopoietic stem cells. We studied expression from eR1 in the stomach and the roles of gastric stem cells in gastric carcinogenesis in transgenic mice. METHODS: We used in situ hybridization and immunofluorescence analyses to study expression of Runx1 in gastric tissues from C57BL/6 (control) mice...
September 23, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27610469/abrogation-of-muc5ac-expression-contributes-to-the-apoptosis-and-cell-cycle-arrest-of-colon-cancer-cells
#7
Xijia Zhu, Xiangkai Long, Xishun Luo, Zhike Song, Shengguo Li, Haipeng Wang
Deregulated expressions of mucins have been found in various malignancies and play a pivotal role in carcinogenesis. MUC5AC, as a secreted mucin, is reported to be aberrantly expressed during epithelial cancer progression, including colon cancer. However, the mechanisms of the oncoprotein MUC5AC in the initiation of colon cancer requires further investigation. Here, we collected colon cancer tissues (n = 20) and corresponding paracancerous tissues (n = 20) and found that the expression of MUC5AC was significantly elevated in colon cancer tissues when compared with the corresponding paracancerous tissues...
September 2016: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27563024/muc-expression-in-gallbladder-epithelial-tissues-in-cholesterol-associated-gallbladder-disease
#8
Kyo-Sang Yoo, Ho Soon Choi, Dae Won Jun, Hang Lak Lee, Oh Young Lee, Byung Chul Yoon, Kyeong Geun Lee, Seung Sam Paik, Yong Seok Kim, Jin Lee
BACKGROUND/AIMS: Gallstone pathogenesis is linked to mucin hypersecretion and bacterial infection. Several mucin genes have been identified in gallbladder epithelial cells (GBECs). We investigated MUC expression in cholesterol-associated gallbladder disease and evaluated the relationship between mucin and bacterial infection. METHODS: The present study involved 20 patients with cholesterol stones with cholecystitis, five with cholesterol stones with cholesterolosis, six with cholesterol polyps, two with gallbladder cancer, and six controls...
September 15, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27497597/the-value-of-a-novel-panel-of-cervical-cancer-biomarkers-for-triage-of-hpv-positive-patients-and-for-detecting-disease-progression
#9
Norbert Varga, Johanna Mózes, Helen Keegan, Christine White, Lynne Kelly, Loretto Pilkington, Márta Benczik, Schaff Zsuzsanna, Gábor Sobel, Róbert Koiss, Edit Babarczi, Miklos Nyíri, Laura Kovács, Sebe Attila, Borbála Kaltenecker, Adrienn Géresi, Adrienn Kocsis, John O'Leary, Cara M Martin, Csaba Jeney
In the era of primary vaccination against HPV and at the beginning of the low prevalence of cervical lesions, introduction of screening methods that can distinguish between low- and high-grade lesions is necessary in order to maintain the positive predictive value of screening. This case-control study included 562 women who attended cervical screening or were referred for colposcopy and 140 disease free controls, confirmed by histology and/or cytology. The cases were stratified by age. Using routine exfoliated liquid based cytological samples RT-PCR measurements of biomarker genes, high-risk HPV testing and liquid based cytology were performed and used to evaluate different testing protocols including sets of genes/tests with different test cut-offs for the diagnostic panels...
August 6, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27459100/overexpression-of-kif11-in-gastric-cancer-with-intestinal-mucin-phenotype
#10
Takeharu Imai, Naohide Oue, Masahiro Nishioka, Shoichiro Mukai, Takashi Oshima, Naoya Sakamoto, Kazuhiro Sentani, Keisuke Matsusaki, Kazuhiro Yoshida, Wataru Yasui
OBJECTIVE: Gastric cancer (GC) is one of the most common human cancers. A useful method of gastric cancer stem cell (CSC) characterization is spheroid colony formation. Previously, we reported that KIF11 expression is >2-fold in spheroid-body-forming GC cells compared with parental cells. Here, we analyzed the expression and distribution of KIF11 in human GC by immunohistochemistry. METHODS: Expression of KIF11 in 165 GC cases was determined using immunohistochemistry...
2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27449137/a-phase-1-dose-escalation-study-of-neo-102-in-patients-with-refractory-colon-and-pancreatic-cancer
#11
Muhammad S Beg, Nilofer S Azad, Sandip P Patel, Jose Torrealba, Sharon Mavroukakis, Melony A Beatson, Xue Ping Wang, Philip M Arlen, Michael A Morse
PURPOSE: NEO-102 is a novel chimeric IgG1 monoclonal antibody which recognizes a variant form of MUC5AC expressed specifically by human pancreatic and colorectal tumors. Preclinical models have demonstrated encouraging signs of anti-tumor activity through antibody-dependent cell-mediated cytotoxicity. METHODS: This is a phase 1, dose-escalation trial of NEO-102 (Ensituximab) for patients with refractory pancreatic and colorectal cancer. The primary objective was to determine safety and tolerability of escalating doses of NEO-102...
September 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27447751/troy-is-expressed-in-human-stomach-mucosa-and-a-novel-putative-prognostic-marker-of-intestinal-type-gastric-cancer
#12
Franziska Wilhelm, Christine Böger, Sandra Krüger, Hans-Michael Behrens, Christoph Röcken
Epithelial stem cells of gastrointestinal tissues are characterized and controlled by an active Wnt signaling. Recently, the Wnt target gene Troy has been proposed as a neoplastic marker in the murine intestine. In this study, we explored the putative tumor biological significance of Troy in humans by using immunohistochemistry (104 cases), quantitative RT-PCR (50 cases) and cell culture experiments (MKN45, MKN74). In the non-neoplastic gastric mucosa, Troy was expressed by Muc5AC-positive foveolar epithelium, parietal cells, chief cells and cells of the intestinal metaplasia...
July 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27369807/evaluations-of-thyme-extract-effects-in-human-normal-bronchial-and-tracheal-epithelial-cell-lines-and-in-human-lung-cancer-cell-line
#13
Marinelli Oliviero, Iannarelli Romilde, Morelli Maria Beatrice, Valisi Matteo, Nicotra Giovanna, Amantini Consuelo, Cardinali Claudio, Santoni Giorgio, Maggi Filippo, Nabissi Massimo
Thyme (Thymus vulgaris) is used traditionally to prepare herbal remedies possessing expectorant, mucolytic, antitussive and antispasmodic properties. The aim of the present study was to investigate the effects of a standardized hydroalcoholic extract of thyme on primary human airway (bronchial/tracheal) epithelial cell lines in a model of lung inflammation induced by LPS. In addition, the effects of thyme extract on human lung cancer cell line (H460) were analysed. Thyme extract showed significant anti-inflammatory properties by reducing the NF-κB p65 and NF-κB p52 transcription factors protein levels followed by the decrease of pro-inflammatory cytokines (IL-1 beta and IL-8), and Muc5ac secretion in human normal bronchial and tracheal epithelial cells...
August 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27347157/differential-expression-of-mucins-in-middle-eastern-patients-with-colorectal-cancer
#14
Khayal Al-Khayal, Maha Abdulla, Omar Al-Obaid, Ahmad Zubaidi, Mansoor-Ali Vaali-Mohammed, Abdulmalik Alsheikh, Rehan Ahmad
Mucin overexpression has been implicated in the tumorigenesis and progression of colorectal carcinoma (CRC). However, data obtained on the prognostic importance of mucin expression in CRC is inconsistent. Due to lack of data on mucin expression and the increase in CRC incidence in Saudi Arabia, the aim of the present study was to analyze the mucin expression profile in patients with CRC in this ethnic group. The present study consisted of 22 patients that underwent surgery for CRC. Histopathological and immunohistochemical staining was performed on CRC tumor and adjacent normal tissues...
July 2016: Oncology Letters
https://www.readbyqxmd.com/read/27298226/muc1-muc2-muc5ac-and-muc6-in-colorectal-cancer-expression-profiles-and-clinical-significance
#15
Johannes Betge, Nora I Schneider, Lars Harbaum, Marion J Pollheimer, Richard A Lindtner, Peter Kornprat, Matthias P Ebert, Cord Langner
Mucin glycoprotein expression can be altered during the carcinogenic process. The impact on the prognosis of patients with colorectal cancer (CRC) is controversial. We analyzed tumors from 381 patients for MUC1, MUC2, MUC5AC, and MUC6 expression by immunohistochemical staining, using tissue microarrays. Progression-free and cancer-specific survival were determined using the Kaplan-Meier method. Expression of intestinal mucin MUC2 was lost in 85 (23 %) CRCs, and patients with MUC6-negative tumors showed shorter progression-free survival (PFS, p = 0...
September 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27165582/semiquantitative-immunohistochemistry-for-mucin-muc1-muc2-muc3-muc4-muc5ac-and-muc6-profiling-of-pancreatic-ductal-cell-adenocarcinoma-improves-diagnostic-and-prognostic-performance
#16
Marek Sierzega, Damian Młynarski, Romana Tomaszewska, Jan Kulig
AIMS: Mucin (MUC) glycoproteins are involved in various steps of the carcinogenesis and progression of human malignancies. The aim of this study was to verify whether semiquantitative evaluation of MUC staining by immunohistochemistry may help to differentiate pancreatic ductal cell adenocarcinoma (PDAC) from chronic pancreatitis and normal pancreas. METHODS AND RESULTS: Mucin expression was examined by immunohistochemistry in surgical specimens resected from 101 patients with PDAC and 33 with chronic pancreatitis, and in 40 normal pancreatic tissue specimens...
October 2016: Histopathology
https://www.readbyqxmd.com/read/27126664/metastasis-of-extra-ampullary-duodenal-adenocarcinoma-to-the-uterine-cervix
#17
K Takahashi, H Yoshida, R Watanabe, M Ishikawa, S I Ikeda, T Kato
Secondary metastatic tumours of the uterine cervix are rare. There have been no reports of duodenal cancer metastasizing to the uterine cervix. Here we present a rare case of an extra-ampullary duodenal adenocarcinoma that has metastasized to the uterine cervix. The patient was a 71-year-old woman who had surgery for an extra-ampullary duodenal adenocarcinoma five years previously. Follow-up examination revealed a suspicious right ovarian mass and nodules in the cervix and posterior fornix of the vagina. Biopsies suggested squamous cell carcinoma in the cervix and adenocarcinoma in the fornix...
April 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/27079739/mucinous-balls-tangled-with-mesothelial-cells-and-muc2-positive-cancer-cells-in-the-ascites-of-pseudomyxoma-peritonei
#18
Shizuka Akashi, Hiroko Kuwabara, Emi Yasuda, Hiroshi Akutagawa, Atsushi Takeshita, Yoshitaka Kurisu, Yutaro Egashira, Yoshinobu Hirose, Masako Yuki, Yasuhiro Tsuda, Michihiro Hayashi
Pseudomyxoma peritonei (PMP) is characterized by extensive mucinous ascites following rupture of mucinous neoplasms of an intra-abdominal origin, and contain secreted gel-forming mucins such as MUC2 and MUC5AC. We encountered a 66-year-old Japanese man complaining of abdominal distension. Ascites at the site was gelatinous upon gross examination, and needle aspirate smears showed histiocytes and many mucinous balls wrapped in spindle cells, which were positive for vimentin, pan-cytokeratin, and podoplanin. The cell block showed several adenocarcinoma clusters, which were positive for MUC2, MUC5AC, CK20, and CDX-2, and negative for CK7...
July 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27026089/colorectal-cancer-in-crohn-s-colitis-is-comparable-to-sporadic-colorectal-cancer
#19
Jochen K Lennerz, Kimberley W J van der Sloot, Long Phi Le, Julie M Batten, Jae Young Han, Kenneth C Fan, Corey A Siegel, Amitabh Srivastava, Do Youn Park, Jey-Hsin Chen, Bruce E Sands, Joshua R Korzenik, Robert D Odze, Dora Dias-Santagata, Darrell R Borger, Hamed Khalili, A John Iafrate, Gregory Y Lauwers
PURPOSE: It is now recognized that Crohn's disease (CD), similar to ulcerative colitis (UC), carries an up to 20-fold higher cancer risk, and the development of colorectal carcinoma (CRC) is a major long-term complication. Once CRC is present, molecular profiling is one of the components in selecting appropriate treatment strategies; however, in contrast to UC, genetic alterations in Crohn's colitis-associated CRC are poorly understood. METHODS: In a series of 227 patients with Crohn's colitis, we identified 33 cases of CRC (~14 %) and performed targeted mutational analysis of BRAF/KRAS/NRAS and determined microsatellite status as well as immunophenotype of the tumors...
May 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27021504/magnifying-endoscopy-with-narrow-band-imaging-of-early-gastric-cancer-correlation-with-histopathology-and-mucin-phenotype
#20
Kyung-Sun Ok, Gwang Ha Kim, Do Youn Park, Hyun Jeong Lee, Hye Kyung Jeon, Dong Hoon Baek, Bong Eun Lee, Geun Am Song
BACKGROUND/AIMS: Magnifying endoscopy with narrow band imaging (ME-NBI) is a useful modality for the detailed visualization of microsurface (MS) and microvascular (MV) structures in the gastrointestinal tract. This study aimed to determine whether the MS and MV patterns in ME-NBI differ according to the histologic type, invasion depth, and mucin phenotype of early gastric cancers (EGCs). METHODS: The MS and MV patterns of 160 lesions in 160 patients with EGC who underwent ME-NBI before endoscopic or surgical resection were prospectively collected and analyzed...
July 15, 2016: Gut and Liver
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