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Interleukin 22 lung cancer

Caner Cam, Bulent Karagoz, Tuba Muftuoglu, Oguz Bigi, Levent Emirzeoglu, Serkan Celik, Alpaslan Ozgun, Tolga Tuncel, Cihan Top
AIM OF THE STUDY: Interleukin (IL)-17 and IL-23 play roles in inflammation and autoimmunity. The function of the IL-17/IL-23 pathway has not been completely evaluated in cancer patients. We aimed to investigate serum IL-17 and IL-23 levels and their relationship with clinicopathological and biochemical parameters in lung cancer patients. MATERIAL AND METHODS: Forty-five lung cancer patients and 46 healthy volunteers were included in the study. IL-17 and IL-23 measurements were made with the ELISA method...
2016: Contemporary Oncology Współczesna Onkologia
W Naumnik, B Naumnik, W Niklińska, M Ossolińska, E Chyczewska
Hepatocyte growth factor (HGF) is involved in tumorigenesis, interleukin-20 (IL-20) is an inhibitor of angiogenesis, and interleukin-22 (IL-22) stimulates tumor growth. The aim of this study was to determine the level of HGF, IL-20, and IL-22 in both serum and bronchoalveolar lavage fluid (BALF) of non-small cell lung cancer (NSCLC) patients before onset of chemotherapy, the nature of the interrelationships between these markers, and their prognostic significance regarding post-chemotherapy survival time. We studied 46 NSCLC patients and 15 healthy subjects as a control group...
August 30, 2016: Advances in Experimental Medicine and Biology
Yu-Hua Chen, Bi-Yun Zhou, Xian-Jing Wu, Jun-Fa Xu, Jun-Ai Zhang, Yong-Hua Chen, Si-Si Liang
In the present study, we aimed to investigate the effects of CC chemokine ligand 22 (CCL22) and interleukin-37 (IL-37) on the proliferation and epithelial-mesenchymal transition (EMT) of non-small cell lung cancer (NSCLC) A549 cells. pDsRed-CCL22 and pEGFP-IL-37 plasmids were constructed. A549 cells were divided into six groups: the control, the pDsRed-N1 blank plasmid, the pEGFP-C1 blank plasmid, the pDsRed-CCL22 plasmid, the pEGFP‑IL-37 plasmid and the pDsRed-CCL22 + pEGFP-IL-37 plasmid group. Expression levels and localization of CCL22 and IL-37 in cells were detected by confocal microscopy...
October 2016: Oncology Reports
Amanda Tufman, Rudolf Maria Huber, Stefanie Völk, Frederic Aigner, Martin Edelmann, Fernando Gamarra, Rosemarie Kiefl, Kathrin Kahnert, Fei Tian, Anne-Laure Boulesteix, Stefan Endres, Sebastian Kobold
BACKGROUND: Interleukin-22 (IL-22) is involved in lung diseases such as pneumonia, asthma and lung cancer. Lavage mirrors the local environment, and may provide insights into the presence and role of IL-22 in patients. METHODS: Bronchoscopic lavage (BL) samples (n = 195, including bronchoalveolar lavage and bronchial washings) were analysed for IL-22 using an enzyme-linked immunosorbent assay. Clinical characteristics and parameters from lavage and serum were correlated with lavage IL-22 concentrations...
2016: BMC Cancer
Kuan-Yuan Chen, Po-Hao Feng, Chih-Cheng Chang, Tzu-Tao Chen, Hsiao-Chi Chuang, Chun-Nin Lee, Chien-Ling Su, Lian-Yu Lin, Kang-Yun Lee
Lymphocytic pleurisy is commonly observed in tuberculosis and cancer. Noninvasive biomarkers are needed to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE) because current clinical diagnostic procedures are often invasive. We identified immune response biomarkers that can discriminate between TPE and MPE. Fourteen pleural effusion biomarkers were compared in 22 MPE patients and five TPE patients. Of the innate immunity biomarkers, the median levels of interleukin (IL)-1β and interferon-induced protein-10 (IP-10) were higher in TPE patients than in MPE patients (P<0...
2016: International Journal of General Medicine
Chengshui Chen, Lin Shi, Yuping Li, Xiangdong Wang, Shuanying Yang
Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome that occurs as a result of various risk factors, including either direct or indirect lung injury, and systemic inflammation triggered also by severe pneumonia (SP). SP-ARDS-associated morbidity and mortality remains high also due to the lack of disease-specific biomarkers. The present study aimed at identifying disease-specific biomarkers in SP or SP-ARDS by integrating proteomic profiles of inflammatory mediators with clinical informatics...
June 2016: Cell Biology and Toxicology
Yi Bi, Jingyan Cao, Shi Jin, Liyan Lv, Li Qi, Fang Liu, Jianxiong Geng, Yan Yu
Lung cancer continues to be an enormous burden on current health care systems throughout the world, with more than a million deaths every year. Previous studies have shown that interleukin-22 (IL-22) promotes survival and resistance to chemotherapy in human lung cancer cells. However, the association of IL-22 expression with recurrence of lung cancer is still unclear. In this study, we found that expression of IL-22 was upregulated in tumor tissues and serum from patients with recurrent non-small cell lung cancer (NSCLC) as compared to primary NSCLC samples...
April 2016: Molecular and Cellular Biochemistry
Elisabeth Quoix, Hervé Lena, Gyorgy Losonczy, Frédéric Forget, Christos Chouaid, Zsolt Papai, Radj Gervais, Christian Ottensmeier, Aleksandra Szczesna, Andrzej Kazarnowicz, Joseph T Beck, Virginie Westeel, Enriqueta Felip, Didier Debieuvre, Anne Madroszyk, Julien Adam, Gisèle Lacoste, Annette Tavernaro, Bérangère Bastien, Céline Halluard, Tania Palanché, Jean-Marc Limacher
BACKGROUND: MUC1 is a tumour-associated antigen expressed by many solid tumours, including non-small-cell lung cancer. TG4010 is a modified vaccinia Ankara expressing MUC1 and interleukin 2. In a previous study, TG4010 combined with chemotherapy showed activity in non-small-cell lung cancer and the baseline value of CD16, CD56, CD69 triple-positive activated lymphocytes (TrPAL) was shown to be potentially predictive of TG4010 efficacy. In this phase 2b part of the phase 2b/3 TIME trial, we further assess TG4010 in combination with first-line chemotherapy and use of the TrPAL biomarker in this setting...
February 2016: Lancet Oncology
Chen Liao, Zu-Bin Yu, Gang Meng, Li Wang, Qing-Yun Liu, Liu-Tong Chen, Shuang-Shuang Feng, Hong-Bo Tu, Ya-Fei Li, Li Bai
BACKGROUND: CD4 (+) T helper 17 (Th17) cells play critical roles in inflammation and tumor development. The involvement of Th17 cells in chronic obstructive pulmonary disease (COPD)-type inflammation-associated lung cancer has also been confirmed in animal models. However, to the authors' knowledge, it is unknown whether the role of Th17 cells is different in patients with lung cancer complicated with COPD compared with those without COPD. In the current study, the authors attempted to determine the association between the circulating levels of Th17-related cytokines and the clinical characteristics of non-small cell lung cancer (NSCLC) in patients with or without COPD...
September 1, 2015: Cancer
Celine M Op den Kamp, Harry R Gosker, Suzanne Lagarde, Daniel Y Tan, Frank J Snepvangers, Anne-Marie C Dingemans, Ramon C J Langen, Annemie M W J Schols
BACKGROUND: Cachexia augments cancer-related mortality and has devastating effects on quality of life. Pre-clinical studies indicate that systemic inflammation-induced loss of muscle oxidative phenotype (OXPHEN) stimulates cancer-induced muscle wasting. The aim of the current proof of concept study is to validate the presence of muscle OXPHEN loss in newly diagnosed patients with lung cancer, especially in those with cachexia. METHODS: Quadriceps muscle biopsies of comprehensively phenotyped pre-cachectic (n = 10) and cachectic (n = 16) patients with non-small cell lung cancer prior to treatment were compared with healthy age-matched controls (n = 22)...
June 2015: Journal of Cachexia, Sarcopenia and Muscle
Hussein Akil, Amazigh Abbaci, Fabrice Lalloué, Barbara Bessette, Léa M M Costes, Linda Domballe, Sandrine Charreau, Karline Guilloteau, Lucie Karayan-Tapon, François-Xavier Bernard, Franck Morel, Marie-Odile Jauberteau, Jean-Claude Lecron
Interleukin-22 (IL-22) is a member of the IL-10 cytokine family that binds to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. IL-22R expression was initially characterized on epithelial cells, and plays an essential role in a number of inflammatory diseases. Recently, a functional receptor was detected on cancer cells such as hepatocarcinoma and lung carcinoma, but its presence was not reported in glioblastoma (GBM). Two GBM cell lines and 10 primary cell lines established from patients undergoing surgery for malignant GBM were used to investigate the expression of IL-22 and IL-22R by using quantitative RT-PCR, western blotting and confocal microscopy studies...
2015: PloS One
Meiling Sun, Di Yan, Shujuan Jiang, Xianmin Gu, Weixia Ma
OBJECTIVE: To explore the diagnostic value of interleukin-27 (IL-27) in tuberculous pleural effusion. METHODS: A total of 76 patients of pleural effusion treated at Shandong Provincial Hospital from March 2013 to February 2014 in accordance with the natures of effusion fluid were divided into: (1) Tuberculosis group of tuberculous pleural effusion (n = 40), including 22 males and 18 females; aged 19 to 73 years; (2) Malignant group of malignant pleural effusion (n = 36), including 20 males and 16 females; aged 33 to 78 years old; including lung cancer (n = 28), lymphoma (n = 3), esophageal (n = 1) and uncertain primary tumor site (n = 4)...
September 16, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Maria F Ramirez, Di Ai, Maria Bauer, Jean-Nicolas Vauthey, Vijaya Gottumukkala, Spencer Kee, Daliah Shon, Mark Truty, Henry M Kuerer, Anrea Kurz, Mike Hernandez, Juan P Cata
BACKGROUND: The cytotoxic activity and count of natural killer (NK) cells appear to be reduced after surgery; however, it is unknown whether the magnitude of this immune suppression is similar among different types of oncological surgery. In this study, we compared the innate immune function of patients undergoing three different oncological surgeries. METHODS: We compared the number and function of NK cells obtained from patients who had undergone mastectomies (n = 17), thoracotomies (n = 21), or liver resections for cancer (n = 22)...
March 2015: Journal of Surgical Research
Guangdie Yang, Hequan Li, Yinan Yao, Fei Xu, Zhang Bao, Jianying Zhou
Accumulating evidence shows that an imbalance in regulatory T cells (Tregs)/T helper IL-17-producing cells (Th17) exists in malignant pleural effusion (MPE). However, the cause of this phenomenon in MPE and the underlying mechanism remain uncertain. The percentages of Tregs and Th17 cells in MPE and parapneumonic effusion (PPE) were determined by flow cytometry. Their specific transcription factors, forkhead box P3 (FoxP3) and retinoic acid-related orphan receptor γt (RORγt); related cytokines, interleukin-6 (IL-6), IL-17, IL-10, and transforming growth factor-β1 (TGF‑β1); and chemokines, C-C motif ligand 17 (CCL17) and CCL20, were analyzed by real-time PCR and ELISA, respectively...
January 2015: Oncology Reports
Fei Liu, Xufeng Pan, Lin Zhou, Jian Zhou, Bin Chen, Jianxin Shi, Wen Gao, Liming Lu
Interleukin (IL)-22, a relatively new member of the IL-10 family, has been implicated in inflammation and tumorigenesis. The aim of this study was to identify genetic polymorphisms in IL-22 and to measure plasma levels of IL-22 in patients with nonsmall cell lung cancer (NSCLC). Patients with NSCLC had a significantly higher frequency of IL-22 rs2227484 CT genotype (odds ratio [OR]=1.917, 95% confidence interval [CI] 1.001-3.670, p=0.038) and T allele (OR=1.878, 95% CI 1.010-3.491, p=0.049) as compared with controls...
October 2014: DNA and Cell Biology
Chrissie Lim, Ram Savan
Interleukin-22 (IL-22) is an IL-10 family cytokine produced by T cells and innate lymphoid cells. The IL-22 signaling pathway orchestrates mucosal immune defense and tissue regeneration through pleiotropic effects including pro-survival signaling, cell migration, dysplasia and angiogenesis. While these functions can prevent initial establishment of tumors, they can also be hijacked by aggressive cancers to enhance tumor growth and metastasis. Thus, the role of the IL-22/IL-22R1 axis in cancer is complex and context-specific...
June 2014: Cytokine & Growth Factor Reviews
Xiao-min Yang, Hua Yang
OBJECTIVE: To explore the expression of high mobility group box-1 (HMGB1) in the lung tissue and serum of patients with pulmonary tuberculosis and to explore its relationship with tumor necrosis factor (TNF)-α and interleukin(IL)-1β. METHODS: Sixty samples of lung tissues were obtained from patients with pulmonary tuberculosis who had underwent pneumonectomy in Department of Chest Surgery, First Affiliated Hospital of Zunyi Medical College from June 2010 to December 2011...
July 2013: Chinese Journal of Tuberculosis and Respiratory Diseases
P Khanna, C-Y Chung, R I Neves, G P Robertson, C Dong
Melanoma cells facilitate endothelial gap formation, the first step during tumor transendothelial migration, which is mediated by both adhesion and endogenously produced chemokines (in particular, interleukin-8 (IL-8)). Tetraspanins are localized to the cell surface in cancer and participate in various functions including invasion of tissues mediated by secretion of cytokines and matrix metalloproteinases. However, little is known about the role of CD82 tetraspanins in malignant melanomas during cancer cell invasion...
May 29, 2014: Oncogene
Waka Ohishi, John B Cologne, Saeko Fujiwara, Gen Suzuki, Tomonori Hayashi, Yasuharu Niwa, Masazumi Akahoshi, Keiko Ueda, Masataka Tsuge, Kazuaki Chayama
Inflammatory markers have been associated with increased risk of several cancers, including colon, lung, breast and liver, but the evidence is inconsistent. We conducted a nested case-control study in the longitudinal cohort of atomic-bomb survivors. The study included 224 hepatocellular carcinoma (HCC) cases and 644 controls individually matched to cases on gender, age, city and time and method of serum storage, and countermatched on radiation dose. We measured C-reactive protein (CRP) and interleukin (IL)-6 using stored sera obtained within 6 years before HCC diagnosis from 188 HCC cases and 605 controls with adequate volumes of donated blood...
January 1, 2014: International Journal of Cancer. Journal International du Cancer
Sebastian Kobold, Stefanie Völk, Till Clauditz, Natascha Jennifer Küpper, Sarah Minner, Amanda Tufman, Peter Düwell, Michael Lindner, Ina Koch, Simon Heidegger, Simon Rothenfuer, Max Schnurr, Rudolf Maria Huber, Waldemar Wilczak, Stefan Endres
INTRODUCTION: In lung cancer, interleukin-22 (IL-22) expression within primary tissue has been demonstrated, but the frequency and the functional consequence of IL-22 signaling have not been addressed. This study aims at analyzing the cellular effects of IL-22 on lung carcinoma cell lines and the prognostic impact of IL-22 tissue expression in lung cancer patients. METHODS: Biological effects of IL-22 signaling were investigated in seven lung cancer cell lines by Western blot, flow cytometry, real-time polymerase chain reaction, and proliferation assays...
August 2013: Journal of Thoracic Oncology
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