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HPV, Cervarix, Human Papilloma Virus, Cervical Cancer, Gardasil

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https://www.readbyqxmd.com/read/27503625/severe-somatoform-and-dysautonomic-syndromes-after-hpv-vaccination-case-series-and-review-of-literature
#1
Beniamino Palmieri, Dimitri Poddighe, Maria Vadalà, Carmen Laurino, Carla Carnovale, Emilio Clementi
Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil(®) and Cervarix(®). Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection of symptoms, indicating nervous system dysfunction, has been described after HPV vaccination. We retrospectively described a case series including 18 girls (aged 12-24 years) referred to our "Second Opinion Medical Network" for the evaluation of "neuropathy with autonomic dysfunction" after HPV vaccination...
August 9, 2016: Immunologic Research
https://www.readbyqxmd.com/read/24970795/an-updated-overview-of-hpv-associated-head-and-neck-carcinomas
#2
REVIEW
Apostolos Zaravinos
Human papilloma virus (HPV)-associated head and neck carcinoma is quite heterogeneous and most of the tumors arise in the oral cavity, oropharynx, hypopharynx and larynx. HPV was just recently recognized as an emerging risk factor for oropharyngeal squamous cell carcinoma (OSCC). HPV(+) tumors represent 5-20% of all head and neck squamous-cell carcinomas (HNSCCs) and 40-90% of those arising from the oropharynx, with widely variable rates depending on the geographic area, population, relative prevalence of environment-related SCC and detection assay...
June 30, 2014: Oncotarget
https://www.readbyqxmd.com/read/23108360/human-papilloma-virus-vaccines-need-to-be-introduced-in-india
#3
Ramesh Verma, Pardeep Khanna
Human papilloma viruses (HPVs) infect the skin and mucosal epithelium of both men and women. There are about 100 types of HPVs, which are differentiated by the genetic sequence of the outer capsid protein L1. More than 30 types of HPVs are sexually transmitted. Most cases of carcinoma of the cervix are caused by HPV. Cervical cancer is one of the most common forms of cancer in women is the second biggest cause of female cancer mortality worldwide. The worldwide incidence of cervical carcinoma is 529,000 per year, and mortality is 275,000, of which an estimated 88% of deaths occur in developing countries...
January 2013: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/22021967/human-papilloma-virus-vaccines-current-scenario
#4
Deepika Pandhi, Sidharth Sonthalia
Genital human papillomavirus (HPV) infection is the most common sexually transmitted infection with an estimated worldwide prevalence of 9-13% and approximately 6 million people being infected each year. Mostly acquired during adolescence or young adulthood, HPV presents clinically as anogenital warts and may progress to precancerous lesions and cancers of the cervix, vagina, vulva, penis and anus, and oropharynx. HPV infection is considered to contribute to almost 100% cervical cancers and at least 80% of anal and 40-60% of vulvar, vaginal, and penile cancers...
July 2011: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/21560109/-diseases-caused-by-human-papilloma-viruses
#5
REVIEW
U Zollner, T F Schwarz
Human papilloma viruses are responsible for a large number of benign and malignant lesions of the skin. HPV 6 and 11 cause up to 90 % of condylomata. Almost each cervical cancer is associated with HPV. HPV 16 und 18 induce up to 70 % of cervical neoplasias. The vaccination against HPV is internationally implemented and should be applied to young girls aged 12 to 17 according to STIKO criteria. The vaccination may reduce the rate of cervical cancer by 70 % and the rate of cervical intraepithelial neoplasia by 50 %...
May 2011: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/21449154/-vaccination-against-human-papilloma-virus-and-cervical-cancer
#6
COMPARATIVE STUDY
Mona Iankovic Kidon, Edward Shechter, Elias Toubi
The human papilloma virus family (HPV], mainly HPV 16, 18 but less HPV 31, 45 were proven to be the cause of cervical intraepithelial neoplasia and cancer. Following natural infection, only half of the infected women develop neutralizing antibodies and even these were of a very Low titer and found to be ineffective. Hence, an efficient vaccination followed by the development of long tasting neutralizing antibodies is needed. Two different vaccines are now Licensed in IsraeL: Cervarix and Gardasil. The first is composed of viral-like particles of HPV 16, 18 and a complex of two adjuvants (aluminum salts and MPL [TLR-4 agonist])...
January 2011: Harefuah
https://www.readbyqxmd.com/read/21250872/advances-in-human-papilloma-virus-vaccines-a-patent-review
#7
REVIEW
Hee-Jeong Cho, Yu-Kyoung Oh, Young Bong Kim
INTRODUCTION: Human papilloma virus (HPV) infection is the main factor associated with the development of cervical cancer. The currently available HPV vaccines, Gardasil and Cervarix, can prevent infection by certain HPV types, but not all. At present, research efforts are being devoted to developing more broad spectrum preventative vaccines, as well as therapeutic vaccines. AREAS COVERED: Recent advances in HPV vaccine development are reviewed in this paper, with a focus on worldwide patents and patent applications...
March 2011: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/19876472/vaccines-against-human-papilloma-virus-and-cervical-cancer-an-overview
#8
Savita Sharma
The paradigm of preventing human papilloma virus (HPV) infection through currently approved vaccines, namely, Gardasil, manufactured by Merck and Co., Inc. (Whitehouse Station, NJ) and Cervarix, manufactured by GlaxoSmithKline (GSK, Philadelphia) holds tremendous promise for the developing countries in decreasing the burden of HPV infection and its sequelae, such as cervical cancer, genital warts and anogenital cancers. Effective screening programs that have reduced the burden of this killer disease in the developed countries are still lacking in India, despite the high incidence of cervical cancer and the implementation of the National Cancer Control Programme since 1975...
July 2008: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/18473731/genetically-modified-cellular-vaccines-for-therapy-of-human-papilloma-virus-type-16-hpv-16-associated-tumours
#9
REVIEW
J Bubenik
Therapeutic strategies based on the insertion of cytokine or other immunostimulatory genes into the genome of tumour cells followed by vaccination with the resulting, genetically modified, cytokine-producing vaccines represent a new potential prospect for the treatment of cancer patients. HPV 16 is the aetiological agent of more than 60 percent human cervical carcinomas (CC). At present, two prophylactic vaccines against HPV 16 are available (GlaxoSmithKline "Cervarix" and Merck "Gardasil"). These vaccines can almost completely protect the immunized individuals against both, persistent HPV 16 infection and HPV 16-related pathological findings in cervical cytology...
May 2008: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/17091900/-anti-hpv-vaccination-preventing-cervical-cancer
#10
P Simon, I Dupond
Two anti-HPV vaccine will soon be registered on the Belgian market. Providing immunity against the L1 protein of several oncogenic types of Papilloma virus, they aim at protecting against cervical cancer and several precancerous lesions. It has been known for years that oncogenic HPV infection of the uterine cervix is a prerequisite to the development of cervical cancer. This is supported by epidemiological has well as biological observations. That is why vaccines against capsid protein of these viruses had been developed...
September 2006: Revue Médicale de Bruxelles
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