Ting Zhao, Zhaojun Mo, Zhifang Ying, Teng Huang, Yanchun Che, Guoliang Li, Xiaolei Yang, Mingbo Sun, Li Jiang, Li Shi, Hui Ye, Zhimei Zhao, Xiaochang Liu, Jing Li, Yanping Li, Rongcheng Li, Ruiju Jiang, Jianfeng Wang, Yuting Fu, Rufei Ma, Hongyuan Shi, Huan Yang, Changgui Li, Jingsi Yang, Qihan Li
BACKGROUND: A comparative analysis of the immunogenicity and safety of different poliovirus immunization schedules in Chinese infants is imperative to guide the administration of efficient strategies for the eradication of poliomyelitis. METHODS: A post hoc analysis was conducted with the data from two poliovirus vaccine clinical trials involving a combined total of 2,400 infants aged 60-90 days. Trivalent oral poliovirus vaccine (tOPV), bivalent oral poliovirus vaccine (bOPV), Sabin strain-based inactivated poliovirus vaccine (sIPV), and conventional inactivated poliovirus vaccine (cIPV) were used in different schedules, the immunogenicity and safety of which were compared 28 days after the last of three doses...
February 2021: Annals of Translational Medicine