keyword
https://read.qxmd.com/read/34072466/immunogenicity-and-safety-of-inactivated-sabin-strain-polio-vaccine-poliovacsin-clinical-trials-phase-i-and-ii
#21
JOURNAL ARTICLE
Anastasia Piniaeva, Georgy Ignatyev, Liubov Kozlovskaya, Yury Ivin, Anastasia Kovpak, Alexander Ivanov, Anna Shishova, Liliia Antonova, Yusuf Khapchaev, Irina Feldblium, Olga Ivanova, Aleksandra Siniugina, Aydar Ishmukhametov
Global polio eradication requires both safe and effective vaccines, and safe production processes. Sabin oral poliomyelitis vaccine (OPV) strains can evolve to virulent viruses and result in poliomyelitis outbreaks, and conventional inactivated poliomyelitis vaccine (Salk-IPV) production includes accumulation of large stocks of neurovirulent wild polioviruses. Therefore, IPV based on attenuated OPV strains seems a viable option. To increase the global supply of affordable inactivated vaccine in the still not-polio free world we developed an IPV made from the Sabin strains-PoliovacSin...
May 29, 2021: Vaccines
https://read.qxmd.com/read/33919442/advax-cpg-adjuvant-provides-antigen-dose-sparing-and-enhanced-immunogenicity-for-inactivated-poliomyelitis-virus-vaccines
#22
JOURNAL ARTICLE
Yoshikazu Honda-Okubo, Jeremy Baldwin, Nikolai Petrovsky
Global immunization campaigns have resulted in a major decline in the global incidence of polio cases, with wild-type poliovirus remaining endemic in only two countries. Live oral polio vaccine (OPV) played a role in the reduction in polio case numbers; however, the risk of OPV developing into circulating vaccine-derived poliovirus makes it unsuitable for eradication programs. Trivalent inactivated polio virus (TIPV) vaccines which contain formalin-inactivated antigens produced from virulent types 1, 2 and 3 reference polio strains grown in Vero monkey kidney cells have been advocated as a replacement for OPV; however, TIPVs have weak immunogenicity and multiple boosts are required before peak neutralizing titers are reached...
April 21, 2021: Pathogens
https://read.qxmd.com/read/33867626/polio-switch-strategy-an-obituary-in-the-making
#23
JOURNAL ARTICLE
M S Mustafa, V Rastogi, P M P Singh
India was certified free of polio in 2014. Until now, the oral polio vaccine (OPV) was being used in India. As the OPV is a live vaccine, vaccine-associated paralytic poliomyelitis may occur after its use. The aim is to replace the OPV with injectable polio vaccine. The Polio Eradication and Endgame Strategic Plan 2013-2018 has been made to eradicate polio. A switch from the trivalent OPV (tOPV) to bivalent OPV (bOPV) has been undertaken in all countries since April 2016. tOPV vials have been withdrawn and replaced by bOPV...
April 2021: Medical Journal, Armed Forces India
https://read.qxmd.com/read/33844811/current-status-of-poliomyelitis-in-latin-america
#24
REVIEW
Luiza Helena Falleiros-Arlant, Silvia E González Ayala, Carla Domingues, Jose Brea, Agustín De Colsa-Ranero
Oral poliovirus vaccine (OPV) has been instrumental in controlling the polio epidemic, and stands out for its safety, efficacy, ease of oral administration, and low cost. However, despite these advantages, as it is a live attenuated virus vaccine, there is the possibility of mutations that confer neurovirulence. Therefore, surveillance for acute flaccid paralysis (AFP) is important, whether associated with live vaccines (VAPP) or vaccine-derived viruses (VDPV). In this review we present important data from Latin America in recent years, where data on VDPV of community transmission, of ambiguous origin and associated with immunodeficiencies are reviewed...
December 2020: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://read.qxmd.com/read/33708880/-post-hoc-analysis-of-two-clinical-trials-to-compare-the-immunogenicity-and-safety-of-different-polio-immunization-schedules-in-chinese-infants
#25
JOURNAL ARTICLE
Ting Zhao, Zhaojun Mo, Zhifang Ying, Teng Huang, Yanchun Che, Guoliang Li, Xiaolei Yang, Mingbo Sun, Li Jiang, Li Shi, Hui Ye, Zhimei Zhao, Xiaochang Liu, Jing Li, Yanping Li, Rongcheng Li, Ruiju Jiang, Jianfeng Wang, Yuting Fu, Rufei Ma, Hongyuan Shi, Huan Yang, Changgui Li, Jingsi Yang, Qihan Li
BACKGROUND: A comparative analysis of the immunogenicity and safety of different poliovirus immunization schedules in Chinese infants is imperative to guide the administration of efficient strategies for the eradication of poliomyelitis. METHODS: A post hoc analysis was conducted with the data from two poliovirus vaccine clinical trials involving a combined total of 2,400 infants aged 60-90 days. Trivalent oral poliovirus vaccine (tOPV), bivalent oral poliovirus vaccine (bOPV), Sabin strain-based inactivated poliovirus vaccine (sIPV), and conventional inactivated poliovirus vaccine (cIPV) were used in different schedules, the immunogenicity and safety of which were compared 28 days after the last of three doses...
February 2021: Annals of Translational Medicine
https://read.qxmd.com/read/33146314/poliomyelitis-eradication-in-four-stages
#26
JOURNAL ARTICLE
José Fernando de Souza Verani, Fernando Laender
This article's objective is to review the "state of the art" in the progress, obstacles, and strategies for achieving global polio eradication. Poliomyelitis control measures began in the 1960s with the advent of two vaccines, the oral polio vaccine (OPV) and the inactivated polio vaccine (IPV). From 1985 to 2020, strategies were implemented to reach the goal of eradication of wild poliovirus (WPV). Following the success with the interruption of indigenous WPV transmission in the Americas, the goal of global eradication was launched...
2020: Cadernos de Saúde Pública
https://read.qxmd.com/read/32883046/case-of-poliomyelitis-caused-by-significantly-diverged-derivative-of-the-poliovirus-type-3-vaccine-sabin-strain-circulating-in-the-orphanage
#27
JOURNAL ARTICLE
Ekaterina A Korotkova, Maria A Prostova, Anatoly P Gmyl, Liubov I Kozlovskaya, Tatiana P Eremeeva, Olga Y Baikova, Alexandr Y Krasota, Nadezhda S Morozova, Olga E Ivanova
Significantly divergent polioviruses (VDPV) derived from the oral poliovirus vaccine (OPV) from Sabin strains, like wild polioviruses, are capable of prolonged transmission and neuropathology. This is mainly shown for VDPV type 2. Here we describe a molecular-epidemiological investigation of a case of VDPV type 3 circulation leading to paralytic poliomyelitis in a child in an orphanage, where OPV has not been used. Samples of feces and blood serum from the patient and 52 contacts from the same orphanage were collected twice and investigated...
September 1, 2020: Viruses
https://read.qxmd.com/read/32645244/potential-future-use-costs-and-value-of-poliovirus-vaccines
#28
JOURNAL ARTICLE
Kimberly M Thompson, Dominika A Kalkowska
Countries face different poliovirus risks, which imply different benefits associated with continued and future use of oral poliovirus vaccine (OPV) and/or inactivated poliovirus vaccine (IPV). With the Global Polio Eradication Initiative (GPEI) continuing to extend its timeline for ending the transmission of all wild polioviruses and to introduce new poliovirus vaccines, the polio vaccine supply chain continues to expand in complexity. The increased complexity leads to significant uncertainty about supply and costs...
February 2021: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://read.qxmd.com/read/32037225/lower-immunity-to-poliomyelitis-viruses-in-australian-young-adults-not-eligible-for-inactivated-polio-vaccine
#29
JOURNAL ARTICLE
Alexandra J Hendry, Frank H Beard, Aditi Dey, Helen Quinn, Linda Hueston, Dominic E Dwyer, Peter B McIntyre
There are limited long-term data on seroprevalence of neutralising antibody (nAb) to the three poliovirus serotypes following the switch from oral polio vaccine (OPV) to inactivated polio vaccine (IPV). In Australia, combination vaccines containing IPV replaced OPV in late 2005. Using serum and plasma specimens collected during 2012 and 2013, we compared prevalence of nAb to poliovirus type 1 (PV1), type 2 (PV2) and type 3 (PV3) in birth cohorts with differing IPV and OPV eligibility from an Australian population-based sample...
March 4, 2020: Vaccine
https://read.qxmd.com/read/31999745/a-novel-gamma-radiation-inactivated-sabin-based-polio-vaccine
#30
JOURNAL ARTICLE
Gregory J Tobin, John K Tobin, Elena K Gaidamakova, Taralyn J Wiggins, Ruth V Bushnell, Wai-Ming Lee, Vera Y Matrosova, Stephen J Dollery, Heather N Meeks, Diana Kouiavskaia, Konstantin Chumakov, Michael J Daly
A concerted action on the part of international agencies and national governments has resulted in the near-eradication of poliomyelitis. However, both the oral polio vaccine (OPV) and the inactivated polio vaccine (IPV) have deficiencies which make them suboptimal for use after global eradication. OPV is composed of attenuated Sabin strains and stimulates robust immunity, but may revert to neurovirulent forms in the intestine which can be shed and infect susceptible contacts. The majority of IPV products are manufactured using pathogenic strains inactivated with formalin...
2020: PloS One
https://read.qxmd.com/read/31801180/sequential-inactivated-ipv-and-live-oral-opv-poliovirus-vaccines-for-preventing-poliomyelitis
#31
JOURNAL ARTICLE
Agustín Ciapponi, Ariel Bardach, Lucila Rey Ares, Demián Glujovsky, María Luisa Cafferata, Silvana Cesaroni, Aikant Bhatti
BACKGROUND: Poliomyelitis mainly affects unvaccinated children under five years of age, causing irreversible paralysis or even death. The oral polio vaccine (OPV) contains live attenuated virus, which can, in rare cases, cause a paralysis known as vaccine-associated paralytic polio (VAPP), and also vaccine-derived polioviruses (VDPVs) due to acquired neurovirulence after prolonged duration of replication. The incidence of poliomyelitis caused by wild polio virus (WPV) has declined dramatically since the introduction of OPV and later the inactivated polio vaccine (IPV), however, the cases of paralysis linked to the OPV are currently more frequent than those related to the WPV...
December 5, 2019: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/31450757/environmental-surveillance-of-polioviruses-in-armenia-colombia-before-trivalent-oral-polio-vaccine-cessation
#32
JOURNAL ARTICLE
María Mercedes González, Magile C Fonseca, Carlos Andrés Rodríguez, Alejandra María Giraldo, José Joaquín Vila, Jhon Carlos Castaño, Leonardo Padilla, Luis Sarmiento
Although acute flaccid paralysis (AFP) surveillance is the "gold standard" for detecting cases of polio, environmental surveillance can provide supplementary information in the absence of paralytic poliomyelitis cases. This study aimed to detect the introduction and/or circulation of wild poliovirus or vaccine-derived polioviruses (VDPV) in wastewater, covering a significant population of Armenia, Colombia, before trivalent oral polio vaccine (OPV) cessation. Between March and September 2015, 24 wastewater samples were collected from eight study sites in eight communes of Armenia, Colombia...
August 23, 2019: Viruses
https://read.qxmd.com/read/31240315/immunogenicity-of-oral-polio-vaccine-and-salk-inactive-polio-vaccine-against-xinjiang-imported-type-1-wild-poliovirus
#33
JOURNAL ARTICLE
Dongmei Yan, Dongyan Wang, Shuangli Zhu, Yong Zhang, Xiaolei Li, Haishu Tang, Jing Guan, Wenbo Xu
BACKGROUND: An outbreak of an imported Type 1 wild poliovirus from Pakistan occurred in the Xinjiang Uygur Autonomous Region of China in 2011, although the local immunity status of the oral polio vaccine (OPV) was relatively satisfied. METHODS: Neutralizing antibody titers against the Xinjiang strain and Sabin 1 strain were measured in 237 sera from 3 groups of fully OPV-vaccinated persons and 1 group of infants fully vaccinated with the inactive polio vaccine (IPV)...
April 15, 2020: Clinical Infectious Diseases
https://read.qxmd.com/read/31095207/remarks-on-the-possibility-of-introducing-the-fractionated-dose-of-the-inactivated-poliomyelitis-vaccine-in-the-latin-american-child-immunization-schedule
#34
JOURNAL ARTICLE
Antonio Arbo, Luiza Helena Falleiros-Arlant, Eduardo L López, José Brea Del Castillo, Celia Martínez de Cuellar, Gabriela Moreno, Roger Rolón, Javier Cerda, Salim Eguiazú
Given that the last notified case of poliomyelitis due to wild poliovirus type 2 was in 1999, in 2012, the Strategic Advisory Group of Experts on Immunization (SAGE) of the World Health Organization (WHO) recommended the withdrawal of the type 2 component of oral polio vaccine (OPV) and the introduction of a bivalent OPV (bOPV) in all countries by 2016. WHO recommended also that the withdrawal should be preceded by the introduction of at least one dose of inactivated poliovirus vaccine (IPV) in routine immunization schedules...
February 2019: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://read.qxmd.com/read/30534926/-remarks-on-the-possibility-of-the-introduction-of-fractionated-dose-of-the-inactivated-poliomyelitis-vaccine-in-the-latin-american-child-immunization-schedule
#35
JOURNAL ARTICLE
Antonio Arbo, Luiza Helena Falleiros-Arlant, Eduardo L López, José Brea Del Castillo, Celia Martínez de Cuellar, Gabriela Moreno, Roger Rolón, Javier Cerda, Salim Eguiazú
As last notified case of poliomyelitis due to wild poliovirus type 2 was 1999, in 2012, the Strategic Advisory Group of Experts on Immunization (SAGE) of the World Health Organization (WHO) recommended the withdrawal of the type 2 component of oral polio vaccine (OPV) and the introduction of bivalent OPV (bOPV) in all countries by 2016. WHO recommended also that the withdrawal should be preceded by the introduction of at least one dose of inactivated poliovirus vaccine (IPV) in routine immunization schedules...
August 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://read.qxmd.com/read/30482835/development-of-thermostable-lyophilized-sabin-inactivated-poliovirus-vaccine
#36
JOURNAL ARTICLE
Woo-Jin Shin, Daiki Hara, Francisca Gbormittah, Hana Chang, Byeong S Chang, Jae U Jung
As oral poliovirus vaccine (OPV) causes vaccine-associated paralytic poliomyelitis, the polio endgame strategy introduced by the Global Polio Eradication Initiative calls for a phased withdrawal of OPV and an introduction of inactivated poliovirus vaccine (IPV). The introduction of IPV creates challenges in maintaining the cold chain for vaccine storage and distribution. Recent advances in lyophilization have helped in finding a temperature-stable formulation for multiple vaccines; however, poliovirus vaccines have yet to capture a stable, safe formula for lyophilization...
November 27, 2018: MBio
https://read.qxmd.com/read/30473498/an-ethical-appraisal-of-the-choice-of-vaccines-against-poliomyelitis
#37
JOURNAL ARTICLE
T Jacob John, Dhanya Dharmapalan
Medical ethics is invoked for immunisation of children as it involves an interaction between a healthcare professional and the child. Immunisation under the national immunisation programme is a public health intervention and the common belief is that ethics is not relevant. Two vaccines with contrasting safety and efficacy profiles were available against polio before the national immunisation programme was launched: the inactivated poliovirus vaccine (IPV) and the live attenuated oral poliovirus vaccine (OPV)...
September 21, 2018: Indian Journal of Medical Ethics
https://read.qxmd.com/read/30376083/pediatric-hiv-infection-and-decreased-prevalence-of-opv-point-mutations-linked-to-vaccine-associated-paralytic-poliomyelitis
#38
JOURNAL ARTICLE
Meira S Halpern, Jonathan Altamirano, Yvonne Maldonado
Background: Mutations associated with prolonged replication of the attenuated polioviruses found in oral poliovirus vaccine (OPV) can lead to vaccine-derived poliovirus (VDPV) and cause paralysis indistinguishable from that caused by wild poliovirus. In response, the World Health Organization has initiated the transition to exclusive use of inactivated poliovirus vaccine (IPV), with OPV administration in cases of outbreak. However, it is currently unclear how IPV-only vaccination, well known to provide humoral but not mucosal immunity, will impact the development of paralysis causing OPV variants...
October 30, 2018: Clinical Infectious Diseases
https://read.qxmd.com/read/30376082/seroprevalence-of-poliomyelitis-antibodies-among-children-aged-1-to-4-years-old-and-factors-associated-with-poliovirus-susceptibility-mexican-health-and-nutrition-survey-2012
#39
JOURNAL ARTICLE
José Alberto Díaz-Quiñónez, José Luis Díaz-Ortega, Pablo Cruz-Hervert, Elizabeth Ferreira-Guerrero, Guadalupe Delgado-Sánchez, Leticia Ferreyra-Reyes, Irma López-Martínez, Belem Torres-Longoria, Rodrigo Aparicio-Antonio, Rogelio Montero-Campos, Norma Mongua-Rodríguez, Lourdes Garcia-Garcia
Background: An essential component of the "Polio Eradication and Endgame Strategic Plan 2013-2018" is the evaluation of population immunity. Mexico introduced the inactivated polio vaccine (IPV) into its routine immunization schedule in 2007 but continued to give trivalent oral polio vaccine OPV twice a year during National Health Weeks through 2016. Methods: To describe the seroprevalence of poliomyelitis among children one to four years old in Mexico and analyze risk factors for susceptibility...
October 30, 2018: Clinical Infectious Diseases
https://read.qxmd.com/read/30376081/immunogenicity-of-new-primary-immunization-schedules-with-inactivated-poliovirus-vaccine-and-bivalent-oral-polio-vaccine-for-the-polio-endgame-a-review
#40
JOURNAL ARTICLE
Ananda S Bandyopadhyay, John F Modlin, Jay Wenger, Chris Gast
In May 2016, countries using oral polio vaccine for routine immunization switched from trivalent oral poliovirus vaccine (tOPV) to bivalent type 1 and 3 OPV (bOPV). This was done in order to reduce risks from type 2 vaccine-derived polioviruses (VDPV2) and vaccine-associated paralytic poliomyelitis (VAPP) and to introduce ≥1 dose of inactivated poliovirus vaccine (IPV) to mitigate post-switch loss of type 2 immunity. We conducted a literature review of studies that assessed humoral and intestinal immunogenicity induced by the newly recommended schedules...
October 30, 2018: Clinical Infectious Diseases
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