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https://www.readbyqxmd.com/read/29190115/quality-of-plant-based-food-materials-and-its-prediction-during-intermittent-drying
#1
Nghia Duc Pham, Md Imran H Khan, M U H Joardder, M M Rahman, Md Mahiuddin, A M Nishani Abesinghe, M A Karim
In most drying processes, several physical, chemical and nutritional modifications take place in food products. Innovative drying techniques such as intermittent drying can enhance the quality of dehydrated products effectively and efficiently. Intermittent drying is a technique where drying conditions are changed through varying the drying air temperature, humidity, velocity, pressure, or even mode of heat input. This drying technique has been successfully applied to overcome the problems of conventional drying systems such as longer time consumption, case hardening, lower energy efficiency and poor-quality attributes...
November 30, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29180046/proteomics-in-cardiovascular-diseases-unveiling-sex-and-gender-differences-in-the-era-of-precision-medicine
#2
Roberta Baetta, Marta Pontremoli, Alma Martinez Fernandez, Corinne M Spickett, Cristina Banfi
Cardiovascular diseases (CVDs) represent the most important cause of mortality in women and in men. Contrary to the long-standing notion that the effects of the major risk factors on CVD outcomes are the same in both sexes, recent evidence recognizes new, potentially independent, sex/gender-related risk factors for CVDs, and sex/gender-differences in the clinical presentation of CVDs have been demonstrated. Furthermore, some therapeutic options may not be equally effective and safe in men and women. In this context, proteomics offers an extremely useful and versatile analytical platform for biomedical researches that expand from the screening of early diagnostic and prognostic biomarkers to the investigation of the molecular mechanisms underlying CDVs...
November 24, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29174271/effects-of-pulsed-electromagnetic-field-therapy-at-different-frequencies-and-durations-on-rotator-cuff-tendon-to-bone-healing-in-a-rat-model
#3
Julianne Huegel, Daniel S Choi, Courtney A Nuss, Mary C C Minnig, Jennica J Tucker, Andrew F Kuntz, Erik I Waldorff, Nianli Zhang, James T Ryaby, Louis J Soslowsky
BACKGROUND: Rotator cuff tears affect millions of individuals each year, often requiring surgical intervention. However, repair failure remains common. We have previously shown that pulsed electromagnetic field (PEMF) therapy improved tendon-to-bone healing in a rat rotator cuff model. The purpose of this study was to determine the influence of both PEMF frequency and exposure time on rotator cuff healing. METHODS: Two hundred ten Sprague-Dawley rats underwent acute bilateral supraspinatus injury and repair followed by either Physio-Stim PEMF or high-frequency PEMF therapy for 1, 3, or 6 hours daily...
November 22, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29170328/31%C3%A2-the-quality-improvement-qip-improving-multidisciplinary-staff-engagement-with-quality-improvement-in-the-rvh-emergency-department
#4
Olly Bannon, Emma Greenwood
: In recent years the RVH Emergency Department (ED) had been under intense pressure and public scrutiny. This led to a demoralised workforce who had become disengaged with quality improvement (QI). QI projects had become an exercise in data collection with little focus on improving care for patients.Two consultants undertook training in QI and then decided to develop a QI project aiming to empower staff and embed QI as daily practice. An ED QI steering group of interested multidisciplinary members was formed and devised an improvement plan to increase staff engagement with QI...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29163606/transgenic-peanut-arachis-hypogaea-l-overexpressing-mtld-gene-showed-improved-photosynthetic-physio-biochemical-and-yield-parameters-under-soil-moisture-deficit-stress-in-lysimeter-system
#5
Kirankumar G Patel, Radhakrishnan Thankappan, Gyan P Mishra, Viralkumar B Mandaliya, Abhay Kumar, Jentibhai R Dobaria
Peanut, an important oilseed crop, frequently encounters drought stress (DS) during its life cycle. In this study, four previously developed mtlD transgenic (T) peanut lines were used for detailed characterization under DS, at the reproductive stage using lysimeter system under controlled greenhouse conditions. In dry-down experiments, T lines maintained better photosynthetic machinery, such as, photosynthesis rate, stomatal conductance, transpiration rate, and SPAD (Soil-Plant Analyses Development) values, and had lower oxidative damage, including lipid membrane peroxidation and hydrogen peroxide and superoxide radical accumulation than WT, when exposed to 24 days of DS...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163199/slow-breathing-can-be-operantly-conditioned-in-the-rat-and-may-reduce-sensitivity-to-experimental-stressors
#6
Donald J Noble, William N Goolsby, Sandra M Garraway, Karmarcha K Martin, Shawn Hochman
In humans, exercises involving slowed respiratory rate (SRR) counter autonomic sympathetic bias and reduce responses to stressors, including in individuals with various degrees of autonomic dysfunction. In the rat, we examined whether operant conditioning could lead to reductions in respiratory rate (RR) and performed preliminary studies to assess whether conditioned SRR was sufficient to decrease physiological and behavioral responsiveness to stressors. RR was continuously monitored during 20 2-h sessions using whole body plethysmography...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29161990/efficient-phenol-removal-from-petrochemical-wastewater-using-biochar-la-ultrasonic-persulphate-system-characteristics-reusability-and-kinetic-study
#7
Rasool Razmi, Bahman Ramavandi, Mehdi Ardjmand, Amir Heydarinasab
The entry of phenol into the environment causes damage to humans and living beings. Hence, it is essential to reduce phenol concentration from wastewaters to below standard level. This research has analysed the physio-chemical properties of a catalyst that has been developed-biochar-La, including BJH, BET, EDX, SEM, FTIR, pHpzc, and iodine number. The catalyst consisted of effective functional groups, including C=S, C-O, C=C, -COOH and O-H, with a specific surface area of 31.2 m(2)/g. The catalyst was used in the biochar-La/ultrasonic/persulphate system to remove phenol from wastewater...
November 22, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29160551/effects-of-pilates-and-yoga-in-patients-with-chronic-neck-pain-a-sonographic-study
#8
Naime Uluğ, Öznur Tunca Yılmaz, Murat Kara, Levent Özçakar
BACKGROUND: Various studies have shown the efficacy of conventional isometric, Pilates and yoga exercises. However, data on the effects and comparison of these specific exercises on the cervical muscle morphology are insufficient or lacking. OBJECTIVE: To investigate the effects of different exercise treatments on neck muscles in patients with chronic neck pain. DESIGN: A randomized study. METHODS: Fifty-six patients with chronic neck pain were randomized into 3 groups as follows: Pilates group (n = 20), yoga group (n = 18) and isometric group (n = 18)...
November 16, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29159972/vitamin-b12-deficiency-and-impaired-expression-of-amnionless-during-aging
#9
Alice Pannérec, Eugenia Migliavacca, Antonio De Castro, Joris Michaud, Sonia Karaz, Laurence Goulet, Serge Rezzi, Tze Pin Ng, Nabil Bosco, Anis Larbi, Jerome N Feige
BACKGROUND: Physical frailty and loss of mobility in elderly individuals lead to reduced independence, quality of life, and increased mortality. Vitamin B12 deficiency has been linked to several age-related chronic diseases, including in the musculo-skeletal system, where vitamin B12 deficiency is generally believed to be linked to poor nutritional intake. In the present study, we asked whether aging and frailty associate with altered vitamin B12 homeostasis in humans and investigated the underlying molecular mechanisms using preclinical models...
November 21, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29133036/1-2-4-thiadiazolidin-3-5-diones-as-novel-hydrogen-sulfide-donors
#10
Beatrice Severino, Angela Corvino, Ferdinando Fiorino, Paolo Luciano, Francesco Frecentese, Elisa Magli, Irene Saccone, Paola Di Vaio, Valentina Citi, Vincenzo Calderone, Luigi Servillo, Rosario Casale, Giuseppe Cirino, Valentina Vellecco, Mariarosaria Bucci, Elisa Perissutti, Vincenzo Santagada, Giuseppe Caliendo
Hydrogen sulfide (H2S) is an endogenous modulator that plays significant physio-pathological roles in several biological systems. In this research field there is a large interest in developing selective CBS and CSE inhibitors and H2S releasing moieties, that could be either used as therapeutic agents or linked to known drugs. One of the major problem is the limited availability of chemicals that ensure a controlled release of H2S in vitro as well in vivo. Aiming to obtain novel H2S donors, whose release properties could be appropriately modulated, we have synthesized a series of 1,2,4-thiadiazolidine-3,5-diones (THIA 1-10) as innovative donors that could release H2S in controlled manner...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29120251/validity-of-the-flemish-working-alliance-inventory-in-a-dutch-physiotherapy-setting-in-patients-with-shoulder-pain
#11
Yasmaine Karel, Marloes Thoomes-De Graaf, Gwendolijne Scholten-Peeters, Paulo Ferreira, Dimitris Rizopoulos, Bart W Koes, Arianne P Verhagen
BACKGROUND: Working alliance is the interaction between the patient and therapist. It is a crucial part of the physiotherapeutic process. One instrument to measure working alliance is available in Dutch/Flemish language and validated in psychotherapy setting. OBJECTIVE: This study aims to validate the Working Alliance Inventory Short-Form in a Dutch physiotherapy setting. DESIGN: A prospective cohort study in primary-care physiotherapy. METHOD: To validate the Dutch/Flemish version of the working alliance inventory short-form (WAV-12) a RASCH analysis was used...
November 9, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29116249/serotonin-drives-the-acquisition-of-a-profibrotic-and-anti-inflammatory-gene-profile-through-the-5-ht7r-pka-signaling-axis
#12
Ángeles Domínguez-Soto, Alicia Usategui, Mateo de Las Casas-Engel, Miriam Simón-Fuentes, Concha Nieto, Víctor D Cuevas, Miguel A Vega, José Luis Pablos, Ángel L Corbí
Peripheral serotonin (5-hydroxytryptamine, 5-HT) regulates cell growth and differentiation in numerous cell types through engagement of seven types of cell surface receptors (HTR1-7). Deregulated 5-HT/HTR levels contribute to pathology in chronic inflammatory diseases, with macrophages being relevant targets for the physio-pathological effects of 5-HT. In fact, 5-HT skews human macrophage polarization through engagement of 5-HT2BR and 5-HT7R receptors. We now report that 5-HT primes macrophages for reduced pro-inflammatory cytokine production and IFN type I-mediated signaling, and promotes an anti-inflammatory and pro-fibrotic gene signature in human macrophages...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29092114/remodeling-mitral-annuloplasty-ring-concept-with-preserved-dynamics-of-annular-height
#13
Søren N Skov, Diana M Røpcke, Marcell J Tjørnild, Christine Ilkjær, Jonas Rasmussen, Hans Nygaard, J M Hasenkam, Morten O Jensen, Sten L Nielsen
BACKGROUND: The configuration of the native annulus changes from nearly flat in the diastolic phase to saddle-shaped in the systolic phase. The present study was conducted to test a novel remodeling annuloplasty ring with built-in septal-lateral fixation and commissural axial flexibility so as to maintain the change in annular saddle shape. The study aim was to evaluate the in-vivo biomechanical performance of the novel annuloplasty ring, compared with the native valve and a semi-rigid and rigid annuloplasty ring...
May 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29079762/physio-biochemical-and-molecular-mechanism-underlying-the-enhanced-heavy-metal-tolerance-in-highland-barley-seedlings-pre-treated-with-low-dose-gamma-irradiation
#14
Xiaojie Wang, Ruonan Ma, Dongjie Cui, Qing Cao, Zhe Shan, Zhen Jiao
Heavy metal pollution, as a consequence of rapid industrialization and urbanization, poses a threat to highland barley grown in Tibet. This study investigates the effect of different doses of gamma irradiation (50-300 Gy) on the physio-biochemical and molecular mechanism of highland barley under heavy metal stress. Growth data showed that 50-Gy gamma irradiation had the maximal beneficial effects on the highland barley seedlings under lead/cadmium stress. The results of oxidative parameters demonstrated that 50-Gy gamma-irradiated seedlings had lower hydrogen peroxide and malondialdehyde contents under lead/cadmium stress compared to non-irradiated seedlings...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29077915/evidence-based-evaluation-of-practice-and-innovation-in-physical-therapy-using-the-ideal-physio-framework
#15
David Beard, David Hamilton, Loretta Davies, Jonathan Cook, Allison Hirst, Peter McCulloch, Arsenio Paez
The IDEAL framework is an established method for initial and ongoing evaluations of innovation and practice for complex health care interventions. First derived for surgical sciences and embedded at a global level for evaluating surgery/surgical devices, the IDEAL framework is based on the principle that innovation and evaluation in clinical practice can, and should, evolve together in an ordered manner: from conception to development and then to validation by appropriate clinical studies and, finally, longer-term follow-up...
October 23, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29056039/kinetic-insights-into-hydrogen-sulfide-delivery-from-caged-carbonyl-sulfide-isomeric-donor-platforms
#16
Yu Zhao, Hillary A Henthorn, Michael D Pluth
Hydrogen sulfide (H2S) is a biologically important small gaseous molecule that exhibits promising protective effects against a variety of physiological and pathological processes. To investigate the expanding roles of H2S in biology, researchers often use H2S donors to mimic enzymatic H2S synthesis or to provide increased H2S levels under specific circumstances. Aligned with the need for new broad and easily modifiable platforms for H2S donation, we report here the preparation and H2S release kinetics from a series of isomeric caged-carbonyl sulfide (COS) compounds, including thiocarbamates, thiocarbonates, and dithiocarbonates, all of which release COS that is quickly converted to H2S by the ubiquitous enzyme carbonic anhydrase...
November 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29045496/at-same-leucine-intake-a-whey-plant-protein-blend-is-not-as-effective-as-whey-to-initiate-a-transient-post-prandial-muscle-anabolic-response-during-a-catabolic-state-in-mini-pigs
#17
Aurélia Revel, Marianne Jarzaguet, Marie-Agnès Peyron, Isabelle Papet, Noureddine Hafnaoui, Carole Migné, Laurent Mosoni, Sergio Polakof, Isabelle Savary-Auzeloux, Didier Rémond, Dominique Dardevet
BACKGROUND: Muscle atrophy has been explained by an anabolic resistance following food intake and an increase of dietary protein intake is recommended. To be optimal, a dietary protein has to be effective not only to initiate but also to prolong a muscle anabolic response in a catabolic state. To our knowledge, whether or not a dairy or a dairy/plant protein blend fulfills these criterions is unknown in a muscle wasting situation. OBJECTIVE: Our aim was, in a control and a catabolic state, to measure continuously muscle anabolism in term of intensity and duration in response to a meal containing casein (CAS), whey (WHEY) or a whey/ plant protein blend (BLEND) and to evaluate the best protein source to elicit the best post prandial anabolism according to the physio-pathological state...
2017: PloS One
https://www.readbyqxmd.com/read/29039925/exosomes-secreted-by-hela-cells-shuttle-on-their-surface-the-plasma-membrane-associated-sialidase-neu3
#18
Lucia Paolini, Flavia Orizio, Sara Busatto, Annalisa Radeghieri, Roberto Bresciani, Paolo Bergese, Eugenio Monti
Sialidases are glycohydrolases that remove terminal sialic acid residues from oligosaccharides, glycolipids, and glycoproteins. The plasma membrane-associated sialidase NEU3 is involved in the fine-tuning of sialic acid-containing glycans directly on the cell surface and plays relevant roles in important biological phenomena such as cell differentiation, molecular recognition, and cancer transformation. Extracellular vesicles are membranous structures with a diameter of 0.03-1 μm released by cells and can be detected in blood, urine, and culture media...
October 27, 2017: Biochemistry
https://www.readbyqxmd.com/read/29034888/generation-of-two-men1-knockout-lines-from-a-human-embryonic-stem-cell-line
#19
Yanli Liu, Aynisahan Ruzi, Dongsheng Guo, Feima Wu, Haikun Liu, Han Wu, Yuhang Wu, Fang Yuan, Yuanqi Zhuang, Fan Yang, Keyu Lai, Liangxue Lai, Yin-Xiong Li
The MEN1 gene is cytogenetically located at 11q13.1 and encodes the nuclear protein menin, which is involved in cell proliferation, apoptosis, differentiation, and metabolism. Here, we generated two MEN1 knockout human embryonic stem cell lines, WAe001-A-4 and WAe001-A-5, by targeting exon-2 and exon-9 of MEN1 using the CRISPR/Cas9 technique. These cell lines maintained their pluripotency, in vitro differentiation potential, normal morphology, and karyotype. These human MEN1-mutated cell lines not only enlarge the pool of lab resources but also provide ideal models to dissect the detailed physio-pathological roles of the menin protein...
October 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29022503/the-renal-outer-medullary-potassium-channel-romk-an-intriguing-pharmacological-target-for-an-innovative-class-of-diuretic-drugs
#20
Vincenzo Calderone, Alma Martelli, Eugenia Piragine, Valentina Citi, Lara Testai, Maria Cristina Breschi
In the last four decades, the several classes of diuretics, currently available for clinical use, have been the first line option for the therapy of widespread cardiovascular and non-cardiovascular diseases. Diuretic drugs generally exhibit an overall favourable risk/benefit balance. However, they are not devoid of side effects. In particular, all the classes of diuretics cause alteration of potassium homeostasis. In recent years, understanding of the physiological role of the renal outer medullary potassium (ROMK) channels, has shown an intriguing pharmacological target for developing an innovative class of diuretic agents: the ROMK inhibitors...
October 12, 2017: Current Medicinal Chemistry
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