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https://www.readbyqxmd.com/read/28105791/the-future-of-pleiotropic-therapy-in-heart-failure-lessons-from-the-benefits-of-exercise-training-on-endothelial-function
#1
REVIEW
Gilles W De Keulenaer, Vincent F M Segers, Faiez Zannad, Dirk L Brutsaert
A novel generation of drugs is introduced in the treatment of heart failure (HF). These drugs, including phosphodiesterase-5 inhibitors, guanylate cyclase stimulators and activators, share the feature that their action is either endothelial-mediated or substitutes for endothelial pathways, in particular the nitric oxide-cyclic guanosine monophosphate pathway, thereby influencing homeostatic balances in virtually each organ system in a pleiotropic fashion. Unfortunately, recent clinical trials with some of these drugs have shown disappointing results, at least in the setting of HF with a preserved ejection fraction...
January 19, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28093647/evaluation-of-particle-size-influence-on-proximate-composition-physicochemical-techno-functional-and-physio-functional-properties-of-flours-obtained-from-persimmon-diospyros-kaki-trumb-coproducts
#2
Raquel Lucas-González, Manuel Viuda-Martos, José Ángel Pérez-Álvarez, Juana Fernández-López
The aim of the work was to study the influence of particle size in the composition, physicochemical, techno-functional and physio-functional properties of two flours obtained from persimmon (Diospyros kaki Trumb. cvs. 'Rojo Brillante' (RBF) and 'Triump' (THF) coproducts. The cultivar (RBF and THF) and particle size significantly affected all parameters under study, although depending on the evaluated property, only one of these effects predominated. Carbohydrates (38.07-46.98 g/100 g) and total dietary fiber (32...
January 16, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28091830/physio-pharmacological-investigations-about-the-anti-inflammatory-and-antinociceptive-efficacy-of-limonene-epoxide
#3
Antonia Amanda Cardoso de Almeida, Renan Oliveira Silva, Lucas Antonio Duarte Nicolau, Tarcísio Vieira de Brito, Damião Pergentino de Sousa, André Luiz Dos Reis Barbosa, Rivelilson Mendes de Freitas, Luciano da Silva Lopes, Jand-Venes Rolim Medeiros, Paulo Michel Pinheiro Ferreira
D-limonene epoxidation generates (+)-limonene epoxide, an understudied compound in the pharmacologically point of view. Herein, we investigated the anti-inflammatory and antinociceptive potentialities of (+)-limonene epoxide and suggested a mechanism of action. The anti-inflammatory potential was analyzed using agents to induce paw edema, permeability, and myeloperoxidase (MPO) activity. Pro-inflammatory cytokines and cell migration of peritoneal cells were also assessed. Antinociceptive effects were evaluated by writhing test induced by acetic acid, formalin, and hot plate assays and contribution of opioid pathways...
January 16, 2017: Inflammation
https://www.readbyqxmd.com/read/28086800/relevance-of-fxr-p62-sqstm1-pathway-for-survival-and-protection-of-mouse-hepatocytes-and-liver-especially-with-steatosis
#4
Sanae Haga, Yimin, Michitaka Ozaki
BACKGROUND: Liver injury and regeneration involve complicated processes and are affected by various physio-pathological conditions. Surgically, severe liver injury after surgical resection often leads to fatal liver failure, especially with some underlying pathological conditions such as steatosis. Therefore, protection from the injury of hepatocytes and liver is a serious concern in various clinical settings. METHODS: We studied the effects of the farnesoid X receptor (FXR) on cell survival and steatosis in mouse hepatocytes (AML12 mouse liver cells) and investigated their molecular mechanisms...
January 13, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28070302/are-life-history-events-of-a-northern-breeding-population-of-cooper-s-hawks-influenced-by-changing-climate
#5
Robert N Rosenfield, Madeline G Hardin, John Bielefeldt, Edward R Keyel
Numerous studies have demonstrated earlier timing of spring migration and egg-laying in small passerines, but documentation of such responses to recent climate change in the life histories of higher trophic feeding birds such as raptors is relatively scarce. Raptors may be particularly susceptible to possible adverse effects of climate change due to their longer generation turnover times and lower reproductive capacity, which could lead to population declines because of an inability to match reproductive timing with optimal brood rearing conditions...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28061931/synergistic-effect-of-hormones-and-biosolids-on-scenedesmus-abundans-for-eliciting-total-biolipids
#6
Chelladurai Chellamboli, Muthiah Perumalsamy
  This study states an integrated approach to grow Scenedesmus abundans in the presence of biostimulants as a robust flourishing organism pertaining to attain the maximum yield of the biodiesel through transesterification. These assessments are especially targeted to achieve the appreciable profit on biodiesel using three biostimulants such as, Indole 3-acetic acid (3 IAA), 6-Benzylaminopurine (6 BAP), and Gibberellic acid (GA) hormones. The proposed schema proved a rise in biomass; as well as lipid content, compared with an alga grown in the absence of hormones...
December 1, 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28004775/effects-of-elevated-mean-and-extremely-high-temperatures-on-the-physio-ecological-characteristics-of-geographically-distinctive-populations-of-cunninghamia-lanceolata
#7
Ting Zhou, Xiaorong Jia, Huixuan Liao, Shijia Peng, Shaolin Peng
Conventional models for predicting species distribution under global warming scenarios often treat one species as a homogeneous whole. In the present study, we selected Cunninghamia lanceolata (C. lanceolata), a widely distributed species in China, to investigate the physio-ecological responses of five populations under different temperature regimes. The results demonstrate that increased mean temperatures induce increased growth performance among northern populations, which exhibited the greatest germination capacity and largest increase in the overlap between the growth curve and the monthly average temperature...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27998128/universal-approach-for-predicting-crystallography-of-heterogeneous-epitaxial-nanocrystals-with-multiple-orientation-relationships
#8
Hongwei Liu, Xuan Cheng, Nagarajan Valanoor
Heteroepitaxial nanocrystals are one of the most fundamentally and technologically important classes of materials systems. The correlation between form, dictated by crystallographic features such as growth habit and direction, and function, in terms of the ultimate physio-chemical properties is well established, thus placing an onus on precise synthesis control of nanocrystal morphology. Yet, nanocrystal heteroepitaxy can be a frustrating, time-consuming iterative process, particularly during the initial stages of development...
December 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27993527/use-of-electric-field-sensors-for-recording-respiration-heart-rate-and-stereotyped-motor-behaviors-in-the-rodent-home-cage
#9
Donald J Noble, Camden J MacDowell, Michael L McKinnon, Tamra I Neblett, William N Goolsby, Shawn Hochman
BACKGROUND: Numerous environmental and genetic factors can contribute significantly to behavioral and cardiorespiratory variability observed experimentally. Affordable technologies that allow for noninvasive home cage capture of physio-behavioral variables should enhance understanding of inter-animal variability including after experimental interventions. NEW METHOD: We assessed whether EPIC electric field sensors (Plessey Semiconductors) embedded within or attached externally to a rodent's home cage could accurately record respiration, heart rate, and motor behaviors...
February 1, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27992458/long-term-effects-of-xerophytic-shrub-haloxylon-ammodendron-plantations-on-soil-properties-and-vegetation-dynamics-in-northwest-china
#10
Baoli Fan, Aiping Zhang, Yi Yang, Quanlin Ma, Xuemin Li, Changming Zhao
The xerophytic desert shrub Haloxylon ammodendron (C. A. Mey.) Bunge. is distributed naturally in Asian and African deserts, and is widely used for vegetation restoration in the desert regions of Northern China. However, there are limited long-term chrono-sequence studies on the impact of changed soil properties and vegetation dynamics following establishment of this shrub on mobile sand dunes. In Minqin County, Gansu Province, we investigated soil properties and herbaceous vegetation development of 10, 20, 30, 40, 50-year-old H...
2016: PloS One
https://www.readbyqxmd.com/read/27987672/antibacterial-activity-of-agricultural-waste-derived-wollastonite-doped-with-copper-for-bone-tissue-engineering
#11
S Azeena, N Subhapradha, N Selvamurugan, S Narayan, N Srinivasan, R Murugesan, T W Chung, A Moorthi
Bioactive ceramic materials with metal ions generation brought great attention in the class of biomaterials development and widely employed as a filler material for bone tissue regeneration. The present study aimed to fabricate calcium silicate based ceramic material doped with copper metal particles by sol-gel method. Rice straw of agricultural waste was utilized as a source material to synthesize wollastonite, then wollastonite was doped with copper to fabricate copper doped wollastonite (Cu-Ws) particles...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27957531/noradrenaline-from-locus-coeruleus-neurons-acts-on-pedunculo-pontine-neurons-to-prevent-rem-sleep-and-induces-its-loss-associated-effects-in-rats
#12
Mudasir Ahmad Khanday, Bindu I Somarajan, Rachna Mehta, Birendra Nath Mallick
Normally, rapid eye movement sleep (REMS) does not appear during waking or non-REMS. Isolated, independent studies showed that elevated noradrenaline (NA) levels inhibit REMS and induce REMS loss-associated cytomolecular, cytomorphological, psychosomatic changes and associated symptoms. However, the source of NA and its target in the brain for REMS regulation and function in health and diseases remained to be confirmed in vivo. Using tyrosine hydroxylase (TH)-siRNA and virus-coated TH-shRNA in normal freely moving rats, we downregulated NA synthesis in locus coeruleus (LC) REM-OFF neurons in vivo...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27939208/evergreen-or-deciduous-trees-for-capturing-pahs-from-ambient-air-a-case-study
#13
Flavia De Nicola, Estefanía Concha Graña, Purificación López Mahía, Soledad Muniategui Lorenzo, Darío Prada Rodríguez, Rubén Retuerto, Alejo Carballeira, Jesús R Aboal, J Ángel Fernández
Tree canopies play a key role in the cycling of polycyclic aromatic hydrocarbons (PAHs) in terrestrial ecosystems, as leaves can capture PAHs from the air. In this study, accumulation of PAHs was compared in an evergreen species, P. pinaster, and in a deciduous species, Q. robur, in relation to some physio-morphological characteristics. For this purpose, pine needles and oak leaves collected from different sites across Galicia (NW Spain) were analysed to determine PAH contents, specific leaf area, stomatal density and conductance...
February 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27919220/deepqa-improving-the-estimation-of-single-protein-model-quality-with-deep-belief-networks
#14
Renzhi Cao, Debswapna Bhattacharya, Jie Hou, Jianlin Cheng
BACKGROUND: Protein quality assessment (QA) useful for ranking and selecting protein models has long been viewed as one of the major challenges for protein tertiary structure prediction. Especially, estimating the quality of a single protein model, which is important for selecting a few good models out of a large model pool consisting of mostly low-quality models, is still a largely unsolved problem. RESULTS: We introduce a novel single-model quality assessment method DeepQA based on deep belief network that utilizes a number of selected features describing the quality of a model from different perspectives, such as energy, physio-chemical characteristics, and structural information...
December 5, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27913103/ontogeny-aging-and-gender-related-changes-in-hepatic-multidrug-resistant-protein-genes-in-rats
#15
Qiong-Ni Zhu, Wei-Yu Hou, Shang-Fu Xu, Yuan-Fu Lu, Jie Liu
: Multidrug resistance proteins (Mrps) are efflux transporters playing important roles in endogenous substances and xenobiotics transport out of the liver. Children, elderly, gender and physio-pathological conditions could influence their expression and result in changes in drug disposition. AIM: This study was aimed to examine the development-, ageing-, and sex-dependent changes in Mrp1-4 and ATP-binding cassette sub-family G member 2 (Abcg2) gene expressions in livers of rats...
November 29, 2016: Life Sciences
https://www.readbyqxmd.com/read/27913062/physiotherapists-and-general-practitioners-attitudes-towards-physio-direct-phone-based-musculoskeletal-physiotherapy-services-a-national-survey
#16
Nicholas Harland, Brian Blacklidge
OBJECTIVES: Physiotherapy phone based, "Physio Direct" (PD) musculoskeletal triage and treat services are a relatively new phenomena. This study explored Physiotherapist and GP attitudes towards PD services. DESIGN: Online national survey via cascade e-mail initiated by study leads. PARTICIPANTS: 488 Physiotherapists and 68 GPs completed the survey. OUTCOME MEASURES: The survey asked three negatively worded and three positively worded Likert scale questions regarding PD services...
September 17, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27912844/heparanase-from-basic-research-to-therapeutic-applications-in-cancer-and-inflammation
#17
Israel Vlodavsky, Preeti Singh, Ilanit Boyango, Lilach Gutter-Kapon, Michael Elkin, Ralph D Sanderson, Neta Ilan
Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, angiogenesis and metastasis. Heparanase expression is enhanced in almost all cancers examined including various carcinomas, sarcomas and hematological malignancies. Numerous clinical association studies have consistently demonstrated that upregulation of heparanase expression correlates with increased tumor size, tumor angiogenesis, enhanced metastasis and poor prognosis. In contrast, knockdown of heparanase or treatments of tumor-bearing mice with heparanase-inhibiting compounds, markedly attenuate tumor progression further underscoring the potential of anti-heparanase therapy for multiple types of cancer...
November 2016: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/27909943/simulating-different-dosing-scenarios-for-a-child-appropriate-valproate-er-formulation-in-a-new-pediatric-two-stage-dissolution-model
#18
Frank Karkossa, Antonia Krueger, Jana Urbaniak, Sandra Klein
Predictive in vitro test methods addressing the parameters relevant to drug release in the pediatric gastrointestinal tract could be an appropriate means for reducing the number of in vivo studies in children. However, dissolution models addressing the particular features of pediatric gastrointestinal physiology and typical pediatric dosing scenarios have not yet been described. The objective of the present study was to combine the knowledge on common vehicle types and properties and current information on pediatric gastrointestinal physiology to design a dissolution model that enables a biorelevant simulation of the gastrointestinal conditions in young children...
December 1, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27832957/the-physio-toolbox-for-modeling-physiological-noise-in-fmri-data
#19
Lars Kasper, Steffen Bollmann, Andreea O Diaconescu, Chloe Hutton, Jakob Heinzle, Sandra Iglesias, Tobias U Hauser, Miriam Sebold, Zina-Mary Manjaly, Klaas P Pruessmann, Klaas E Stephan
BACKGROUND: Physiological noise is one of the major confounds for fMRI. A common class of correction methods model noise from peripheral measures, such as ECGs or pneumatic belts. However, physiological noise correction has not emerged as a standard preprocessing step for fMRI data yet due to: (1) the varying data quality of physiological recordings, (2) non-standardized peripheral data formats and (3) the lack of full automatization of processing and modeling physiology, required for large-cohort studies...
January 30, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27818943/analysis-of-distribution-of-dna-methylation-in-kidney-renal-clear-cell-carcinoma-specific-genes-using-entropy
#20
Nithya Ramakrishnan, R Bose
DNA Methylation is an epigenetic phenomenon in which methyl groups are added to the cytosines, thereby altering the physio-chemical properties of the DNA region and influencing gene expression. Aberrant DNA methylation in a set of genes or across the genome results in many epigenetic diseases including cancer. In this paper, we use entropy to analyze the extent and distribution of DNA methylation in Tumor Suppressor Genes (TSG's) and Oncogenes related to a specific type of cancer (viz.) KIRC (Kidney-renal-clear-cell-carcinoma)...
December 2016: Genomics Data
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