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https://www.readbyqxmd.com/read/28719808/activated-neuro-oxidative-and-neuro-nitrosative-pathways-at-the-end-of-term-are-associated-with-inflammation-and-physio-somatic-and-depression-symptoms-while-predicting-outcome-characteristics-in-mother-and-baby
#1
Chutima Roomruangwong, Decio Sabbatini Barbosa, Andressa Keiko Matsumoto, André de Souza Nogueira, Buranee Kanchanatawan, Sunee Sirivichayakul, André F Carvalho, Sebastien Duleu, Michel Geffard, Estefania Gastaldello Moreira, Michael Maes
OBJECTIVES: To examine oxidative & nitrosative stress (O&NS) biomarkers at the end of term in relation to perinatal affective symptoms, neuro-immune biomarkers and pregnancy-related outcome variables. METHODS: We measured plasma advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical trapping antioxidant parameter (TRAP), -sulfhydryl (-SH), peroxides (LOOH) and paraoxonase (PON)1 activity in pregnant women with and without prenatal depression and non-pregnant controls...
July 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28717850/physio-biochemical-parameters-a-potential-tool-for-target-selective-treatment-of-haemonchosis-in-the-small-ruminants
#2
Bhupamani Das, Niranjan Kumar, Mehul M Jadav, Jayesh B Solanki, T K S Rao
This study aims to evaluate the conjunctiva colour-based FAMACHA score (FS) coupled with a body condition score (BCS), haemogram and stressor hormone level estimation, in identifying post-mortem (PM)/coproscopically proven individuals wanting therapy for economically important gastrointestinal (GI) helminths, Haemonchus contortus, in the small ruminants. The incidence of haemonchosis was significantly (p < 0.05) higher (60.81%) in the ruminants with FS = 3. The H. contortus count in the animals with FS 2, 3 and 4 was 23...
July 17, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28713411/physiological-biochemical-epigenetic-and-molecular-analyses-of-wheat-triticum-aestivum-genotypes-with-contrasting-salt-tolerance
#3
Suresh Kumar, A S Beena, Monika Awana, Archana Singh
Abiotic stress exerts significant impact on plant's growth, development, and productivity. Productivity of crop plants under salt stress is lagging behind because of our limited knowledge about physiological, biochemical, epigenetic, and molecular mechanisms of salt tolerance in plants. This study aimed to investigate physio-biochemical, molecular indices and defense responses of selected wheat cultivars to identify the most contrasting salt-responsive genotypes and the mechanisms associated with their differential responses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28709447/cryptic-amyloidogenic-elements-in-mutant-nefh-causing-charcot-marie-tooth-2-trigger-aggresome-formation-and-neuronal-death
#4
Arnaud Jacquier, Cécile Delorme, Edwige Belotti, Raoul Juntas-Morales, Guilhem Solé, Odile Dubourg, Marianne Giroux, Claude-Alain Maurage, Valérie Castellani, Adriana Rebelo, Alexander Abrams, Stephan Züchner, Tanya Stojkovic, Laurent Schaeffer, Philippe Latour
Neurofilament heavy chain (NEFH) gene was recently identified to cause autosomal dominant axonal Charcot-Marie-Tooth disease (CMT2cc). However, the clinical spectrum of this condition and the physio-pathological pathway remain to be delineated. We report 12 patients from two French families with axonal dominantly inherited form of CMT caused by two new mutations in the NEFH gene. A remarkable feature was the early involvement of proximal muscles of the lower limbs associated with pyramidal signs in some patients...
July 14, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28704400/genome-wide-analysis-of-the-ccch-zinc-finger-family-identifies-tissue-specific-and-stress-responsive-candidates-in-chickpea-cicer-arietinum-l
#5
Seema Pradhan, Chandra Kant, Subodh Verma, Sabhyata Bhatia
The CCCH zinc finger is a group of proteins characterised by a typical motif consisting of three cysteine residues and one histidine residue. These proteins have been reported to play important roles in regulation of plant growth, developmental processes and environmental responses. In the present study, genome wide analysis of the CCCH zinc finger gene family was carried out in the available chickpea genome. Various bioinformatics tools were employed to predict 58 CCCH zinc finger genes in chickpea (designated CarC3H1-58), which were analysed for their physio-chemical properties...
2017: PloS One
https://www.readbyqxmd.com/read/28701767/actomyosin-and-vimentin-cytoskeletal-networks-regulate-nuclear-shape-mechanics-and-chromatin-organization
#6
Michael C Keeling, Luis R Flores, Asad H Dodhy, Elizabeth R Murray, Núria Gavara
The regulation of nuclear state by the cytoskeleton is an important part of cellular function. Actomyosin stress fibres, microtubules and intermediate filaments have distinct and complementary roles in integrating the nucleus into its environment and influencing its mechanical state. However, the interconnectedness of cytoskeletal networks makes it difficult to dissect their individual effects on the nucleus. We use simple image analysis approaches to characterize nuclear state, estimating nuclear volume, Poisson's ratio, apparent elastic modulus and chromatin condensation...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701038/micellear-gold-nanoparticle-as-delivery-vehicle-for-dual-tyrosine-kinase-inhibitor-zd6474-for-metastatic-breast-cancer-treatment
#7
Siddik Sarkar, Suraj Konar, Nagaprasad Puvvada, Shashi Rajput, Bn Prashanth Kumar, Raj R Rao, Amita Pathak, Paul B Fisher, Mahitosh Mandal
Therapeutic index of poorly water soluble drugs are often hampered due to poor pharmokinetics, reduced blood retention and lack of effective drug concentrations in the tumor region. In order to overcome these issues, drugs are often delivered using delivery vehicles to provide an enhanced therapeutic index. Gold nanoparticles synthesized in micellar networks of amphiphilic block copolymer (AuNM) provide an efficient nanocarrier for tissue- and site-specific drug delivery owing to their low cytotoxicity and immunogenicity...
July 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28700973/fit-for-purpose-wastewater-treatment-testing-to-implementation-of-decision-support-tool-ii
#8
Gyan Chhipi-Shrestha, Kasun Hewage, Rehan Sadiq
This paper is the second in a series of two papers. In Paper I, a decision support tool (DST), FitWater, was developed for evaluating the potential of wastewater treatment (WWT) trains for various water reuse applications. In the present paper, the proposed DST has been tested and implemented. FitWater has been tested with several existing WWT plants in Canada and the USA, demonstrating FitWater's effectiveness in estimating life cycle cost (LCC), health risk, and energy use. FitWater has also been implemented in a newly planned neighbourhood in the Okanagan Valley (BC, Canada) by developing 12 alternative WWT trains for water reuse in lawn and public parks irrigation...
July 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28699026/aminolevulinic-acid-and-nitric-oxide-regulate-oxidative-defense-and-secondary-metabolisms-in-canola-brassica-napus-l-under-drought-stress
#9
Nudrat Aisha Akram, Majid Iqbal, Atta Muhammad, Muhammad Ashraf, Fahad Al-Qurainy, Sidra Shafiq
To minimize the damaging effects of stresses, plant growth regulators (PGRs) are widely used to sustain the plant life under stress-prone environments. So, a study was carried out to evaluate the response of two canola (Brassica napus L.) cultivars, Dunkeld and Cyclone, to foliar-applied two potential PGRs, nitric oxide (NO) and 5-aminolevulinic acid, under water deficit conditions. In this study, the levels of NO and ALA used were 0.02 and 0.895 mM, respectively. Plants of both canola cultivars were subjected to control (100% field capacity) and water deficit (60% field capacity)...
July 12, 2017: Protoplasma
https://www.readbyqxmd.com/read/28683564/noncoding-rnas-in-the-vascular-system-response-to-oxidative-stress
#10
Paola Fuschi, Biagina Maimone, Carlo Gaetano, Fabio Martelli
SIGNIFICANCE: Redox homeostasis plays a pivotal role in vascular cell function and its imbalance has a causal role in a variety of vascular diseases. Accordingly, the response of mammalian cells to redox cues requires precise transcriptional and post-transcriptional modulation of gene expression patterns. Recent Advances: Mounting evidence shows that non-protein-coding RNAs (ncRNAs) are important for the functional regulation of most, if not all, cellular processes and tissues. Not surprisingly, a prominent role of ncRNAs has been identified also in the vascular system response to oxidative stress...
July 6, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28683199/unfolding-igdq-peptides-for-engineering-motogenic-interfaces
#11
Federica De Leo, Riccardo Marega, Valentina Corvaglia, Rodolfo Tondo, Matteo Lo Cicero, Simone Silvestrini, Davide Bonifazi
Extracellular matrix (ECM)-mimicking surfaces are pivotal tools in understanding adherent cell physiopathology. In this sense, we have recently reported on a discrete set of ECM-mimicking SAMs, among which only those exposing IGDQ peptide-alkanethiols sustain the adhesion of MDA-MB-231 cells by triggering FAK phosphorylation and peculiarly induce the migration of individual cancer cells on the subcentimeter scale. Starting from the experimentally observed relationship among the SAM composition, organization, and biological response, a systematic computational characterization aided in pinpointing the atomistic details through which specific composition and organization achieve the desired biological responsiveness...
July 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28679281/lipid-mediated-modulation-of-intracellular-ion-channels-and-redox-state-physio-pathological-implications
#12
Marisa Brini, Luigi Leanza, Ildiko Szabo
<i>Significance</i>: Ion channels play an important role in the regulation of organelle function within the cell, as proven by increasing evidence pointing to a link between altered function of intracellular ion channels and different pathologies ranging from cancer to neurodegenerative diseases, ischemic damage and lysosomal storage diseases. <i>Recent Advances</i>: A link between these pathologies and redox state as well as lipid homeostasis and ion channel function is in the focus of current research...
July 5, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28677361/change-gout-the-need-for-a-new-approach
#13
Leonardo Punzi
Gout is the most common form of inflammatory arthropathy and is caused by an excess of uric acid in the blood (hyperuricemia). It is a chronic, debilitating condition that gradually increases in severity and affects an increasing number of people. It has a wide spectrum of clinical manifestations and is related to serious kidney and cardiovascular conditions and to an increased risk of mortality. The negative perception of the disease, historically seen as related to a life of dissipation, has led to underestimating its impact and focusing the attention on the short-term treatment of acute attacks rather than on the long-term management of the condition without, consequently, preventing the most serious complications...
August 2017: Minerva Medica
https://www.readbyqxmd.com/read/28674717/obstetric-brachial-plexus-injury-knowledge-among-health-care-providers-in-saudi-arabia
#14
Rakan S Al-Essa, Rakan M Al-Khilaiwi, Ali A Al-Qahtani, Abdullah M Al-Thunayan, Mohammad M Al-Qattan
To assess the basic knowledge on obstetric brachial plexus injury among obstetricians, pediatricians, and physio-/occupational therapists in major hospitals in Riyadh.  We aimed to identify if inadequate knowledge is the reason behind delayed referrals to the Hand Clinic. Methods: This is a cross-sectional questionnaire-based study  conducted at 5 major hospitals in Riyadh, Saudi Arabia between June 2015 and August 2015.  A questionnaire of 6 questions (multiple choice closed-ended questions) was given to obstetricians, pediatricians, and  physio-/occupational therapists' in these selected hospitals...
July 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28667801/a-study-of-selected-factors-affecting-efficacy-of-compost-tea-against-several-fungal-pathogens-of-potato
#15
W K Mengesha, W M Gill, S M Powell, K J Evans, K M Barry
AIM: To investigate selected factors of two non-aerated compost teas and mechanisms that influence the restriction of several fungal potato pathogens. METHODS AND RESULTS: Two non-aerated compost teas (NCTs, commercial compost, CCT; vineyard compost, VCT) were tested for their ability to suppress potato pathogens. The VCT was more suppressive than CCT to mycelial growth of A. solani and R. solani isolate 299, but not for R. solani isolate 422. Metagenomic studies of microbial diversity revealed that the CCT had higher fungal and bacterial diversity and richness than the VCT...
July 1, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28666234/physio-biochemical-basis-of-iron-sulfide-nanoparticle-induced-growth-and-seed-yield-enhancement-in-b-%C3%A2-juncea
#16
Madhu Rawat, Rajeev Nayan, Bhawana Negi, M G H Zaidi, Sandeep Arora
Metal nanoparticles have been reported to influence plant growth and productivity. However, the molecular mechanisms underlying the effects have not been completely understood yet. Current work describes the physio-biochemical basis of iron sulfide nanoparticle induced growth and yield enhancement in Brassica juncea. Iron sulfide nanoparticles (0, 2, 4, 6, 8 and 10 ppm) were used for foliar treatment of B. juncea at 30, 45 and 60 days after sowing, under field conditions. Foliar treatment of 4 ppm iron sulfide nanoparticle solution at 30 days after sowing brought maximal enhancement in agronomic attributes of the treated plants...
June 20, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28660143/distal-triceps-injuries-including-snapping-triceps-a-systematic-review-of-the-literature
#17
Kimberley Shuttlewood, James Beazley, Christopher D Smith
AIM: To review current literature on types of distal triceps injury and determine diagnosis and appropriate management. METHODS: We performed a systematic review in PubMed, Cochrane and EMBASE using the terms distal triceps tears and snapping triceps on the 10(th) January 2017. We excluded all animal, review, foreign language and repeat papers. We reviewed all papers for relevance and of the papers left we were able to establish the types of distal triceps injury, how these injuries are diagnosed and investigated and the types of management of these injuries including surgical...
June 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28656265/bioinformatic-analysis-reveals-potential-properties-of-human-claudin-6-regulation-and-functions
#18
Dongjing Lin, Yaxiong Guo, Yanru Li, Yang Ruan, Mingzi Zhang, Xiangshu Jin, Minlan Yang, Yan Lu, Peiye Song, Shuai Zhao, Bing Dong, Yinping Xie, Qihua Dang, Chengshi Quan
Claudin-6 (CLDN6) is an integral component of the tight junction proteins in polarized epithelial and endothelial cells and plays a crucial role in maintaining cell integrity. Deregulation of CLDN6 expression and distribution in tumor tissues have been widely documented and correlated with cancer progression and metastasis. However, a complete mechanistic understanding of CLDN6 regulation and function remains to be studied. Herein, we show new potential properties of CLDN6 regulation and functions from bioinformatics analysis...
June 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28650102/endocrine-influence-on-neuroinflammation-the-use-of-reporter-systems
#19
REVIEW
Nicoletta Rizzi, Alessandro Villa, Valeria Benedusi, Electra Brunialti, Nicoletta Cesari, Paolo Ciana, Adriana Maggi
Most of the ageing-associated pathologies are coupled with a strong inflammatory component that accelerates the progress of the physio-pathological functional decline related to ageing. The currently available pharmacological tools for the control of neuroinflammation present several side effects which restrict their application, particularly in chronic disorders. The discovery of the potential anti-inflammatory action exerted by endogenous estrogens and that activation of ERα results in a significant decrease of inflammation at the cellular level and in models of inflammatory diseases, prompted us to embark in a series of studies aimed at the generation of reporter systems allowing to i...
June 26, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28650095/sex-differences-in-brain-mitochondrial-metabolism-influence-of-endogenous-steroids-and-stroke
#20
REVIEW
P Gaignard, M Fréchou, P Liere, P Thérond, M Schumacher, A Slama, R Guennoun
Steroids are neuroprotective and growing body of evidence indicates that mitochondria are a potential target of their effects. The mitochondria are the site of cellular energy synthesis, regulate oxidative stress and play a key role in cell death after brain injury and neurodegenerative diseases. After a summary of the literature on the general functions of mitochondria and the effects of sex steroid administrations on mitochondrial metabolism, we will summarize and discuss our recent findings concerning sex differences in brain mitochondrial function in physiological and pathological conditions...
June 26, 2017: Journal of Neuroendocrinology
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