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https://www.readbyqxmd.com/read/28723587/evaluation-of-an-electronic-clinical-decision-support-tool-for-incident-elevated-bp-in-adolescents
#1
Elyse Olshen Kharbanda, Stephen E Asche, Alan Sinaiko, James D Nordin, Heidi L Ekstrom, Patricia Fontaine, Steven P Dehmer, Nancy E Sherwood, Patrick J O'Connor
OBJECTIVE: To evaluate, among adolescents 10-17 years with an incident hypertensive BP (≥95(th) percentile) at a primary care visit, whether TeenBP, a novel electronic health record (EHR) linked clinical decision support tool (CDS), improved recognition of elevated BP and return for follow-up BP evaluation. METHODS: We conducted a pragmatic cluster randomized trial in 20 primary care clinics in a large Midwestern medical group. Ten clinics received the TeenBP CDS, including an alert to remeasure a hypertensive BP at that visit, an alert that a hypertensive BP should be repeated in 1-3 weeks and patient-specific order sets...
July 16, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28718893/association-between-maternal-vascular-murmur-and-the-small-for-gestational-age-fetus-with-abnormal-umbilical-artery-doppler-flow
#2
Diana Riknagel, Richard Farlie, Morten Hedegaard, Peter Humaidan, Johannes J Struijk
OBJECTIVE: To investigate the association between maternal vascular murmurs (MVMs) and fetal growth restriction (defined as small-for-gestational-age [SGA] fetus) and abnormal Doppler pulsatility index (PI) of the uterine and/or umbilical arteries. METHODS: A cross-sectional study of women aged 18 years or older with a singleton pregnancy at 28-34 weeks was conducted at Regional Hospital Viborg, Denmark, between May 1 and August 1, 2013. Ultrasound fetal biometry was performed and the Doppler PI of the umbilical and uterine arteries was determined...
July 18, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28713999/elevated-fibrinogen%C3%A2-like-protein-2-in-tnbs%C3%A2-induced-colitis-mice-association-with-th17-and-regulatory-t-cells
#3
Haihua Lin, Renpin Chen, Xuepei Jiang, Xiaoli Wu, Xielin Huang, Xiuli Dong, Xu Yang, Xiuqing Lin, Xin Chen, Xiangrong Chen, Zhiming Huang
The etiology and pathogenesis of inflammatory bowel disease (IBD) is complex and remains to be completely elucidated. Numerous cytokines are associated with the initiation and development of IBD. Fibrinogen‑like protein 2 (FGL2), an immunosuppressive cytokine expressed by regulatory cluster of differentiation (CD)4+ T (Treg) cells, has been identified to be important for immunomodulatory activity in the inflammatory state. Therefore, the present study investigated the expression of FGL2 and interleukin (IL)‑17 in trinitro‑benzene‑sulfonic acid (TNBS)‑induced colitis mice to identify the function of FGL2, based on the effector CD4+ T helper (Th)17/Treg balance, in IBD...
July 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28713936/epigallocatechin-gallate-attenuates-overload%C3%A2-induced-cardiac-ecm-remodeling-via-restoring-t-cell-homeostasis
#4
Yongsheng Han, Qingtong Wang, Xizhen Fan, Jun Chu, Junfu Peng, Yousheng Zhu, Yan Li, Xiaojing Li, Lei Shen, James Asenso, Shanfeng Li
It has previously been demonstrated that Epigallocatechin gallate (EGCG) has regulatory effects on cellular immunity. The present study explored whether EGCG inhibits the overload‑induced cardiac extracellular matrix (ECM) remodeling through targeting the balance of T cell subpopulations. Sprague‑Dawley rats were subjected to either transverse aortic constriction (TAC) or sham operation. TAC rats were treated with EGCG or valsartan (Val) for 6 weeks. The administration of EGCG or Val ameliorated the overproduction of cardiac collagen, inhibited matrix metalloproteinase (MMP) activity, decreased the expression of tissue inhibitor of MMP‑2, atrial natriuretic peptide and brain natriuretic peptide...
July 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28713729/piezosurgery-versus-rotatory-osteotomy-in-mandibular-impacted-third-molar-extraction
#5
Bharat Bhati, Pankaj Kukreja, Sanjeev Kumar, Vidhi C Rathi, Kanika Singh, Shipra Bansal
AIM: The aim of this study is to compare piezoelectric surgery versus rotatory osteotomy technique in removal of mandibular impacted third molar. MATERIALS AND METHODS: Sample size of 30 patients 18 males, 12 females with a mean age of 27.43 ± 5.27. Bilateral extractions were required in all patients. All the patients were randomly allocated to two groups in one group, namely control group, surgical extraction of mandibular third molar was done using conventional rotatory osteotomy and in the other group, namely test group, extraction of lower third molar was done using Piezotome...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28712146/a-reversal-of-the-shift-towards-earlier-spring-phenology-in-several-mediterranean-reptiles-and-amphibians-during-the-1998-2013-warming-slowdown
#6
Roger Prodon, Philippe Geniez, Marc Cheylan, Florence Devers, Isabelle Chuine, Aurelien Besnard
Herps, especially amphibians, are particularly susceptible to climate change, since temperature tightly controls many parameters of their biological cycle - above all, their phenology. The timing of herps' activity or migration period - in particular the dates of their first appearance in spring and first breeding - and the shift to earlier dates in response to warming since the last quarter of the 20(th) century has often been described up to now as a nearly monotonic trend towards earlier phenological events...
July 16, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28702462/adoptive-cell-therapy-of-induced-regulatory-t-cells-expanded-by-tolerogenic-dendritic-cells-on-murine-autoimmune-arthritis
#7
Jie Yang, Lidong Liu, Yiming Yang, Ning Kong, Xueyu Jiang, Juan Sun, Rufeng Xie
OBJECTIVE: Tolerogenic dendritic cells (tDCs) can expand TGF-β-induced regulatory T cells (iTregs); however, the therapeutic utility of these expanded iTregs in autoimmune diseases remains unknown. We sought to determine the properties of iTregs expanded by mature tolerogenic dendritic cells (iTregmtDC) in vitro and explore their potential to ameliorate collagen-induced arthritis (CIA) in a mouse model. METHODS: After induction by TGF-β and expansion by mature tDCs (mtDCs), the phenotype and proliferation of iTregmtDC were assessed by flow cytometry...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28699163/conventional-sunscreen-application-does-not-lead-to-sufficient-body-coverage
#8
Z Jovanovic, Th Schornstein, A Sutor, G Neufang, R Hagens
OBJECTIVE: This study aimed to assess sunscreen application habits and relative body coverage after single whole body application. METHODS: Fifty-two healthy volunteers were asked to use the test product once, following their usual sunscreen application routine. Standardized UV photographs (UVP), which were evaluated by Image Analysis (IA), were conducted before and immediately after product application to evaluate relative body coverage. In addition to these procedures, the volunteers completed an online self-assessment questionnaire (SAS) to assess sunscreen usage habits...
July 12, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28696753/evolution-of-the-reactor-antineutrino-flux-and-spectrum-at-daya-bay
#9
F P An, A B Balantekin, H R Band, M Bishai, S Blyth, D Cao, G F Cao, J Cao, Y L Chan, J F Chang, Y Chang, H S Chen, Q Y Chen, S M Chen, Y X Chen, Y Chen, J Cheng, Z K Cheng, J J Cherwinka, M C Chu, A Chukanov, J P Cummings, Y Y Ding, M V Diwan, M Dolgareva, J Dove, D A Dwyer, W R Edwards, R Gill, M Gonchar, G H Gong, H Gong, M Grassi, W Q Gu, L Guo, X H Guo, Y H Guo, Z Guo, R W Hackenburg, S Hans, M He, K M Heeger, Y K Heng, A Higuera, Y B Hsiung, B Z Hu, T Hu, E C Huang, H X Huang, X T Huang, Y B Huang, P Huber, W Huo, G Hussain, D E Jaffe, K L Jen, X P Ji, X L Ji, J B Jiao, R A Johnson, D Jones, L Kang, S H Kettell, A Khan, S Kohn, M Kramer, K K Kwan, M W Kwok, T J Langford, K Lau, L Lebanowski, J Lee, J H C Lee, R T Lei, R Leitner, J K C Leung, C Li, D J Li, F Li, G S Li, Q J Li, S Li, S C Li, W D Li, X N Li, X Q Li, Y F Li, Z B Li, H Liang, C J Lin, G L Lin, S Lin, S K Lin, Y-C Lin, J J Ling, J M Link, L Littenberg, B R Littlejohn, J L Liu, J C Liu, C W Loh, C Lu, H Q Lu, J S Lu, K B Luk, X Y Ma, X B Ma, Y Q Ma, Y Malyshkin, D A Martinez Caicedo, K T McDonald, R D McKeown, I Mitchell, Y Nakajima, J Napolitano, D Naumov, E Naumova, H Y Ngai, J P Ochoa-Ricoux, A Olshevskiy, H-R Pan, J Park, S Patton, V Pec, J C Peng, L Pinsky, C S J Pun, F Z Qi, M Qi, X Qian, R M Qiu, N Raper, J Ren, R Rosero, B Roskovec, X C Ruan, H Steiner, P Stoler, J L Sun, W Tang, D Taychenachev, K Treskov, K V Tsang, C E Tull, N Viaux, B Viren, V Vorobel, C H Wang, M Wang, N Y Wang, R G Wang, W Wang, X Wang, Y F Wang, Z Wang, Z Wang, Z M Wang, H Y Wei, L J Wen, K Whisnant, C G White, L Whitehead, T Wise, H L H Wong, S C F Wong, E Worcester, C-H Wu, Q Wu, W J Wu, D M Xia, J K Xia, Z Z Xing, J L Xu, Y Xu, T Xue, C G Yang, H Yang, L Yang, M S Yang, M T Yang, Y Z Yang, M Ye, Z Ye, M Yeh, B L Young, Z Y Yu, S Zeng, L Zhan, C Zhang, C C Zhang, H H Zhang, J W Zhang, Q M Zhang, R Zhang, X T Zhang, Y M Zhang, Y X Zhang, Y M Zhang, Z J Zhang, Z Y Zhang, Z P Zhang, J Zhao, L Zhou, H L Zhuang, J H Zou
The Daya Bay experiment has observed correlations between reactor core fuel evolution and changes in the reactor antineutrino flux and energy spectrum. Four antineutrino detectors in two experimental halls were used to identify 2.2 million inverse beta decays (IBDs) over 1230 days spanning multiple fuel cycles for each of six 2.9 GW_{th} reactor cores at the Daya Bay and Ling Ao nuclear power plants. Using detector data spanning effective ^{239}Pu fission fractions F_{239} from 0.25 to 0.35, Daya Bay measures an average IBD yield σ[over ¯]_{f} of (5...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28696024/a-genome-wide-association-analysis-for-carcass-traits-in-a-commercial-duroc-pig-population
#10
P G Eusebi, R González-Prendes, R Quintanilla, J Tibau, T F Cardoso, A Clop, M Amills
We performed a genome-wide association study to map the genetic determinants of carcass traits in 350 Duroc pigs typed with the Porcine SNP60 BeadChip. Association analyses were carried out using the gemma software. The proportion of phenotypic variance explained by the SNPs ranged between negligible to moderate (hSNP2= 0.01-0.30) depending on the trait under consideration. At the genome-wide level, we detected one significant association between backfat thickness between the 3(rd) and 4(th) ribs and six SNPs mapping to SSC12 (37-40 Mb)...
August 2017: Animal Genetics
https://www.readbyqxmd.com/read/28695801/establishment-and-assessment-of-mice-models-of-type-2-diabetes-mellitus
#11
Fangfang Xu, Nan Wang, Gangqiang Li, Wenfang Guo, Caifeng Yang, Dehu Liu
Objective To establish type 2 diabetes mellitus(T2DM)KM mouse models via the combined use of high-calorie diet and multiple administration of low-dose streptozotocin(STZ). Methods Based on the randomized number table,30 KM mice were equally and randomly divided into 2 groups:modeling group and control group. Mice in the modeling group were given foods with high calories for one month and injected with 30 mg/kg STZ via the left lower abdominal cavity for 2-4 consecutive days,while mice in the control group were fed with standard maintenance foods and the same dose of citrate buffer solution...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28693206/role-of-t-helper-17-cytokines-in-the-tumour-immune-inflammation-response-of-patients-with-laryngeal-squamous-cell-carcinoma
#12
Wei-Jing Tang, Lei Tao, Li-Ming Lu, Di Tang, Xiao-Lin Shi
Altered cytokine production can lead to immune dysfunction in patients with cancer. The present study investigated the expression of T helper (Th)17 cytokines in patients with laryngeal squamous cell carcinoma (LSCC) and their clinical significance in providing new therapeutic insights. The prevalence of Th17 cells and their receptors in patients with LSCC was studied using immunohistochemical analysis via tissue microarray technology. Flow cytometry was used to investigate the percentage of Th17 and Th1 cells in peripheral blood mononuclear cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28687154/safety-and-efficacy-for-laparoscopic-versus-open-hepatectomy-a-meta-analysis
#13
REVIEW
Bao Jin, Mei-Ting Chen, Yu-Tong Fei, Shun-da Du, Yi-Lei Mao
BACKGROUND: Laparoscopic hepatectomy (LH) is growing in popularity, but its efficacy and safety are still controversial. Few multicenter, large, population-based, prospective, randomized studies have compared LH with open hepatectomy (OH). We performed a meta-analysis to compare the treatment outcome of patients undergoing LH versus OH. METHODS: We searched PubMed, EMBASE, Cochrane Central Register, CNKI, and WanFang Med Online databases to November 30(th), 2016 for randomized controlled trials (RCTs) that compared treatment outcome for LH and OH...
June 28, 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28684770/effector-t-helper-cell-populations-are-elevated-in-the-bone-marrow-of-rheumatoid-arthritis-patients-and-correlate-with-disease-severity
#14
Shufeng Li, Han Yin, Kaining Zhang, Ting Wang, Yun Yang, Xinguang Liu, Xiaotian Chang, Ming Zhang, Xinfeng Yan, Yanjun Ren, Wenping Pan, Lei Zhang
This study is to investigate the frequencies of T-helper (Th)22, Th17 and Th1 cells and the levels of related cytokines in subchondral bone marrow in patients with rheumatoid arthritis (RA). Bone marrow and peripheral blood samples were collected from RA, osteoarthritis (OA) patients and healthy controls. The frequencies of Th22, Th17, and Th1 cells were examined by flow cytometry. Levels of interleukin (IL)-22, IL-17 and IFN-γ were examined by ELISA. Disease Activity Score in 28 joints (DAS28) of RA patients were analyzed...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28681958/bj-2266-ameliorates-experimental-autoimmune-encephalomyelitis-through-down-regulation-of-the-jak-stat-signaling-pathway
#15
Zhiwei You, Maheshwor Timilshina, Byeong-Seon Jeong, Jae-Hoon Chang
CD4(+) T cells differentiate into distinct effector subsets upon antigenic stimulation. Cytokines, and micro-environmental factors present during T-cell priming, direct differentiation of naïve CD4(+) T cells into pro-inflammatory Th1 and Th17 cells. From extensive screening of 2,4,5-trimethylpyridin-3-ol derivatives with various functional groups at C(6)-position, BJ-2266, a 6-thioureido-derivative, showed potent inhibitory activity on in vitro T helper (Th)-cell differentiation. This compound inhibited IFN-γ and IL-17 production from polyclonal CD4(+) T cells and ovalbumin (OVA)-specific CD4(+) T cells that were activated by T-cell receptor (TCR) engagement...
July 6, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28678606/baseline-water-quality-of-municipal-ponds-and-metal-removal-ability-of-typha-latifolia-l-from-sewage-and-industrial-wastewaters
#16
Syeda Huma Bokhari, Muhammad Mahmood-Ul-Hassan, Yousaf Riaz, Anjum Munir, Zeshan Ali
Baseline water quality of municipal effluent of three rural settings of Islamabad was assessed for physicochemical and microbiological parameters by collecting wastewater from inlet and center of ponds. Results showed that water quality was comparatively better at the centre as Typha latifolia plants were growing towards the center of ponds. In another study, wastewater treatment ability of T. latifolia was investigated by growing in industrial and municipal effluent under greenhouse conditions. Water and plant samples were collected periodically (3(rd), 10(th), 17(th), 24(th) and 31(st) day after transplanting) for measurement of Pb, Cu and Cd concentrations...
July 5, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28674179/inflammasome-and-fas-mediated-il-1%C3%AE-contributes-to-th17-th1-cell-induction-in-pathogenic-bacterial-infection-in-vivo
#17
Ryosuke Uchiyama, Shin Yonehara, Shun'ichiro Taniguchi, Satoshi Ishido, Ken J Ishii, Hiroko Tsutsui
CD4(+) Th cells play crucial roles in orchestrating immune responses against pathogenic microbes, after differentiating into effector subsets. Recent research has revealed the importance of IFN-γ and IL-17 double-producing CD4(+) Th cells, termed Th17/Th1 cells, in the induction of autoimmune and inflammatory diseases. In addition, Th17/Th1 cells are involved in the regulation of infection caused by the intracellular bacterium Mycobacterium tuberculosis in humans. However, the precise mechanism of Th17/Th1 induction during pathogen infection is unclear...
July 3, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28667758/tgf-%C3%AE-and-th17-cells-related-injuries-in-patients-with-sulfur-mustard-exposure
#18
REVIEW
Yunes Panahi, Mostafa Ghanei, Saeed Hassani, Amirhossein Sahebkar
Sulfur mustard (SM) is a vesicating agent that has been employed as a chemical warfare agent. High-dose exposure to sulfur mustard may lead to the damage of rapidly proliferating cells of bone marrow and, therefore, suppression of the immune system. This may be continued as dysfunction of the immune system, and ultimately result in secondary immune disorders. Studies have suggested a role for T cells in SM-induced lung injury. Moreover, observations from animal studies indicate a delayed-type hypersensitivity (DTH) response after skin exposure to SM, providing an understanding that SM can stimulate specific T cell-mediated immune responses...
July 1, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28667043/abstracts-of-presentations-at-the-association-of-clinical-scientists-137-th-meeting-birmingham-al-may-17-20-2017
#19
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28665299/cytokine-mediators-of-chronic-graft-versus-host-disease
#20
Kelli Pa MacDonald, Bruce R Blazar, Geoffrey R Hill
Substantial preclinical and clinical research into chronic graft-versus-host disease (cGVHD) has come to fruition in the last five years, generating a clear understanding of a complex cytokine-driven cellular network. cGVHD is mediated by naive T cells differentiating within IL-17-secreting T cell and follicular Th cell paradigms to generate IL-21 and IL-17A, which drive pathogenic germinal center (GC) B cell reactions and monocyte-macrophage differentiation, respectively. cGVHD pathogenesis includes thymic damage, impaired antigen presentation, and a failure in IL-2-dependent Treg homeostasis...
June 30, 2017: Journal of Clinical Investigation
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