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https://www.readbyqxmd.com/read/29336663/lactobacillus-acidophilus-improves-intestinal-inflammation-in-an-acute-colitis-mouse-model-by-regulation-of-th17-and-treg-cell-balance-and-fibrosis-development
#1
Jin-Sil Park, JeongWon Choi, JooYeon Jhun, Ji Ye Kwon, Bo-In Lee, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho
Disruption of the balance among the microbiota, epithelial cells, and resident immune cells in the intestine is involved in the pathogenesis of inflammatory bowel disease (IBD). Probiotics exert protective effects against IBD, and probiotic commensal Lactobacillus species are common inhabitants of the natural microbiota, especially in the gut. To investigate the effects of Lactobacillus acidophilus on the development of IBD, L. acidophilus was administered orally in mice with dextran sodium sulfate (DSS)-induced colitis...
January 16, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29333980/percentages-of-pd-1-cd4-t-cells-and-pd-l1-dcs-are-increased-and-spd-1-level-is-elevated-in-patients-with-immune-thrombocytopenia
#2
Yingying Wang, Nannan Pang, Xinyou Wang, Ying Liu, Xiujuan Wang, Lei Wang, Mingling Sun, Halida Yasen, Fang Zhao, Wenxia Fan, Jianbing Ding, Xinhong Guo
The present study is to measure the expression of programmed death (PD)-1 / programmed death ligand-1 (PD-L1) negative costimulatory molecules, soluble format sPD-1 in patients with immune thrombocytopenia (ITP), and to investigate their correlation with the secretion of cytokines. A total of 35 patients with ITP were included in the present study. Twenty healthy subjects who received physical examination at our hospital were included as control group. Peripheral blood was collected from all ITP patients and healthy subjects...
January 15, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29331587/il-23-il-17-immune-axis-in-guillain-barr%C3%A3-syndrome-exploring-newer-vistas-for-understanding-pathobiology-and-therapeutic-implications
#3
REVIEW
Monojit Debnath, Madhu Nagappa, Geetanjali Murari, Arun B Taly
Guillain Barré Syndrome (GBS) is a severe disorder of the peripheral nervous system with an inadequately known etiopathology. It is a post infectious immune mediated disorder, characterized by autoantibody production, complement activation as well as T reactivity against gangliosides. However, the precise etiopathogenesis remains poorly understood in a majority of the patients. Th17 cells, a recently identified lineage of Th cells have emerged as a predominant inducer of autoimmunity and inflammation in various immunological disorders...
January 10, 2018: Cytokine
https://www.readbyqxmd.com/read/29331376/microrna-425-facilitates-pathogenic-th17-cell-differentiation-by-targeting-forkhead-box-o1-foxo1-and-is-associated-with-inflammatory-bowel-disease
#4
Xue Yang, Qinyu He, Zhenzhen Guo, Fei Xiong, Yi Li, Yan Pan, Caiping Gao, Liangping Li, Chong He
Inflammatory bowel disease (IBD) is a chronic autoimmune disease, and its pathogenesis remains mostly unknown. MicroRNAs (miRs) has drawn much attention as a crucial regulator of autoimmune diseases. In this study, we demonstrated, for the first time, that miR-425 was significantly up-regulated in peripheral blood mononuclear cells (PBMC) and mucosa of patients with IBD. In note, T helper (Th) 17 cells were found to be the major source of miR-425 expression. Using gain-of-function approaches, we demonstrated that miR-425 could facilitate the differentiation of CD4+ T cells into Th17 lineage...
January 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29330859/differential-effects-of-phototherapy-adalimumab-and-betamethasone-calcipotriol-on-effector-and-regulatory-t-cells-in-psoriasis
#5
I S Kotb, B J Lewis, R N Barker, A D Ormerod
BACKGROUND: Psoriasis is a chronic T cell-mediated skin disease with marked social and economic burdens. Current treatments are unsatisfactory, with unpredictable remission times and incompletely understood modes of action. Recent advances in our understanding of the pathogenesis of psoriasis identify the imbalance between CD4+ T effector cells, particularly the T helper (Th) 17 subset, and regulatory T cells (Treg) as key to the development of psoriatic lesions, and therefore a novel therapeutic target...
January 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29330324/betaine-ameliorates-experimental-autoimmune-encephalomyelitis-by-inhibiting-dendritic-cell-derived-il-6-production-and-th17-differentiation
#6
Cuixia Yang, Weiming Lai, Jinfeng Zhou, Xinyuan Zheng, Yingying Cai, Wanjie Yang, Sirong Xie, Yuan Gao, Changsheng Du
IL-17-secreting T cells (Th17 cells) play a pathogenic role in multiple autoimmune diseases, including multiple sclerosis (MS), and dendritic cell (DC)-derived cytokines play pivotal roles in promoting the differentiation of naive CD4+ T cells into Th cell subsets (Th1 and Th17). Therefore, small molecules blocking the key cytokines produced by DCs will be beneficial in MS. In this article, we report that betaine treatment ameliorates MS pathogenesis by inhibiting DC-derived IL-6 production and Th17 differentiation...
January 12, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29326415/factors-affecting-early-school-age-children-s-subjective-happiness-using-the-actor-partner-interdependence-model-of-parental-variables
#7
Kinoh Kang, Jungho Kim, Jungmin Kim, Hyoeun Jeong, Jeongwon Han
PURPOSE: The present study is a descriptive cross-sectional study of cause-and-effect relationship, which used the 7(th) year data of the Panel Study on Korean Children, to investigate the effects of parenting stress, depression, and family interactions of the parents of early school-age children on children's subjective happiness. METHODS: The present study included data of 1419 pairs of parents who participated in the mother and father survey of the Panel Study on Korean Children...
December 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29305925/use-of-therapeutic-hypothermia-among-patients-with-coagulation-disorders-a-nationwide-analysis
#8
Mahek Shah, Kaushal Parikh, Brijesh Patel, Manyoo Agarwal, Lohit Garg, Sahil Agrawal, Shilpkumar Arora, Nilay Patel, Nainesh Patel, William H Frishman
OBJECTIVES: The study aimed to assess the impact of therapeutic hypothermia (TH) on bleeding and in-hospital mortality among patients with coagulation disorders (CD). BACKGROUND: TH affects coagulation factors and platelets putting patients at risk for bleeding and worse outcomes. Effect of TH among patients with CD remains understudied. METHODS: Between 2009 and 2014, a total of 6,469 cases of TH were identified using the National Inpatient Sample out of which 1,036 (16...
January 3, 2018: Resuscitation
https://www.readbyqxmd.com/read/29296975/cell-surface-c-type-lectin-like-receptor-clec-1-dampens-dendritic-cell-activation-and-downstream-th17-responses
#9
Maria Dolores Lopez Robles, Annaick Pallier, Virginie Huchet, Laetitia Le Texier, Severine Remy, Cecile Braudeau, Laurence Delbos, Aurelie Moreau, Cedric Louvet, Carole Brosseau, Pierre-Joseph Royer, Antoine Magnan, Franck Halary, Regis Josien, Maria-Cristina Cuturi, Ignacio Anegon, Elise Chiffoleau
Dendritic cells (DCs) represent essential antigen-presenting cells that are critical for linking innate and adaptive immunity, and influencing T-cell responses. Among pattern recognition receptors, DCs express C-type lectin receptors triggered by both exogenous and endogenous ligands, therefore dictating pathogen response, and also shaping T-cell immunity. We previously described in rat, the expression of the orphan C-type lectin-like receptor-1 (CLEC-1) by DCs and demonstrated in vitro its inhibitory role in downstream T helper 17 (Th17) activation...
March 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29289722/effects-of-adalimumab-on-t-helper-17-lymphocyte-and-neutrophil-related-inflammatory-serum-markers-in-patients-with-moderate-to-severe-hidradenitis-suppurativa
#10
D Jiménez-Gallo, R de la Varga-Martínez, L Ossorio-García, C Collantes-Rodríguez, C Rodríguez, M Linares-Barrios
BACKGROUND: T-helper (Th)-17 lymphocytes and neutrophils are the main sources of the proinflammatory cytokines involved in the pathogenesis of hidradenitis suppurativa (HS). OBJECTIVES: This study aims to evaluate the improvement of the inflammatory serum markers (ISM) levels in patients with moderate-to-severe HS who receive adalimumab. METHODS: Nineteen moderate-to-severe HS patients were prospectively recruited. Each of the patients received 40 mg of adalimumab weekly...
December 28, 2017: Cytokine
https://www.readbyqxmd.com/read/29288381/modulation-of-the-il-23-il-17-axis-by-fenofibrate-ameliorates-the-ovalbumin-lipopolysaccharide-induced-airway-inflammation-and-bronchial-asthma-in-rats
#11
Samah M Elaidy, Soha S Essawy, Mona A Hussain, Mohamed K El-Kherbetawy, Eman R Hamed
The overlapping between asthmatic subtypes, including both CD4+ T helper (TH)2 and TH17 cells, is found in the natural course of allergic asthma, especially in exacerbations and severe and insensitive forms to steroids, which are in need of new molecular therapies. In the TH2-subset mediated asthma, fenofibrate displays therapeutic promises, besides evidenced therapeutic effects on TH17-mediated colitis and myocarditis. Therefore, the effects of fenofibrate versus dexamethasone on IL-23/IL-17 axis in ovalbumin (OVA)/lipopolysaccharide (LPS)-induced airway inflammation and bronchial asthma in rats were explored...
December 30, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29285053/establishment-of-a-mouse-model-of-lipopolysaccharide-induced-neutrophilic-nasal-polyps
#12
Shuibin Wang, Hanwu Zhang, Zulian Xi, Jingjing Huang, Jun Nie, Bin Zhou, Yuqin Deng, Zezhang Tao
Research has identified that gram-negative bacteria have an important role in refractory nasal polyps. In the present study, lipopolysaccharide (LPS) was used to establish a mouse model with neutrophilic nasal polyps in order to explore the effect and mechanism of LPS on the formation of neutrophilic nasal polyps in mice. A total of 5 or 10 µg of LPS was dropped into the nasal cavities of C57BL/6J mice in order to establish animal models with neutrophilic nasal polyps. Histological staining, toll-like receptor 4 (TLR4), cluster of differentiation 68 for macrophages and myeloperoxidase for neutrophil immunohistochemistry were used to observe histopathological changes in the nasal mucosa...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29284895/the-effects-of-aloe-vera-on-tnf-a-levels-the-percentage-of-nk-cells-and-th-17-cells-in-rat-that-received-izoniazid-and-rifampycin
#13
Herin Mawarti, Mukhamad Rajin, Zulfikar Asumta
Background: The present study was undertaken to investigate the hepatoprotective effect of Aloe vera against side effect of antituberculosis drug. Material and methods: Twenty-five rats will be divided into five groups, namely the control group (without any treatment), the group of rats treated with anti-tuberculosis drugs, and a group of rats were treated antituberculosis drugs and got Aloe vera extract at a dose of 40; 80; and 120 mg/kg body weight. Antituberculosis drugs are isoniazid and rifampicin a dose of 50 mg/kg body weight...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29283120/correlation-of-interleukin-33-with-th-cytokines-and-clinical-severity-of-dry-eye-disease
#14
Guoping Luo, Yan Xin, Dajun Qin, Aihua Yan, Zhiyan Zhou, Zhaoxia Liu
PURPOSE: The purpose of this study is to determine the tear and serum protein levels of interleukin-33 (IL-33) and its correlation with Th cytokines and disease severity in dry eye (DE) syndrome. METHODS: Tear and serum samples were collected from 30 healthy volunteers, 30 DE patients with non-Sjogren's syndrome DE (NSSDE) and 30 DE patients with primary SSDE. The eight most frequent symptoms of DE were scored. All patients underwent corneal and conjunctival staining, tear film breakup time (TBUT), and Schirmer I test...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29279268/direct-acting-antiviral-therapy-enhances-total-cd4-and-cd8-t-cells-responses-but-does-not-alter-t-cells-activation-among-hcv-mono-infected-and-hcv-hiv-1-co-infected-patients
#15
Saeid Najafi Fard, Ivan Schietroma, Giuseppe Corano Scheri, Noemi Giustini, Sara Serafino, Eugenio Nelson Cavallari, Claudia Pinacchio, Gabriella De Girolamo, Giancarlo Ceccarelli, Carolina Scagnolari, Vincenzo Vullo, Gabriella d'Ettorre
AIM: Chronic immune activation and poor T-cell immune response are strongly associated with disease progression and pathogenesis of both hepatitis C virus (HCV) and human immunodeficiency virus (HIV)-1 infections. Little is known about the impact of anti-HCV Interferon (IFN)-free direct-acting antiviral (DAA) therapy on the systemic T-cells activation and patterns of peripheral T-cells producing pro-inflammatory cytokines. PATIENTS AND METHODS: Forty-five subjects including 18 HCV mono-infected, 17 HCV/HIV-1 co-infected patients under antiretroviral therapy (ART), and 10 healthy controls (HCs) were recruited...
December 23, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29275585/-impact-of-the-implementation-of-beijing-tobacco-control-regulation-on-outpatient-visits-for-smoking-cessation-in-beijing-chaoyang-hospital
#16
S L Chu, L R Liang, Z H Tong, H Jing, D Zhang, Y Jiang
Objective: To investigate the impact of the implementation of Beijing Tobacco Control Regulation on outpatient visits for smoking cessation in Beijing Chaoyang Hospital. Methods: The outpatient visits and the proportion of returned cases to the total outpatient visits for smoking cessation in Beijing Chaoyang Hospital in past five years (2012-2016) that was before and after the implementation of Beijing Tobacco Control Regulation (June 1(st,) 2015) were analyzed. Time series seasonal index method was used to analyze seasonal variations in the outpatient visits...
November 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29275579/-risk-factors-associated-with-massive-drainage-after-posterior-spinal-orthopaedic-surgery-for-adolescent-scoliosis
#17
N Li, R Jia, X P Gu, Z L Ma
Objective: To identify risk factors that influence the massive drainage after posterior spinal orthopaedic surgery for adolescent scoliosis. Methods: A total of 1 461 patients from 11 to 18 years old diagnosed with adolescent scoliosis who underwent first posterior spinal orthopaedic surgery in affiliated Drum Tower Hospital, Medical School of Nanjing University between November 2010 and October 2015 were retrospectively reviewed. Patients were categorized on the basis of massive or normal drainage, with the boundary 30(th) percentile of drainage/estimated blood volume...
November 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29275078/cost-effectiveness-of-adjuvant-intravaginal-brachytherapy-in-high-intermediate-risk-endometrial-carcinoma
#18
John M Stahl, Shari Damast, Trevor J Bledsoe, Yi An, Vivek Verma, James B Yu, Melissa R Young, Nataniel H Lester-Coll
PURPOSE: We assessed the cost-effectiveness of adjuvant intravaginal brachytherapy (IVBT) vs. observation after total hysterectomy and bilateral salpingo-oophorectomy (TH/BSO) for high-intermediate risk (HIR) endometrial carcinoma. METHODS AND MATERIALS: A Markov model was used to assess the cost-effectiveness of IVBT by comparing average cumulative costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs) between patients allocated to (1) 'observation' or (2) 'IVBT' after TH/BSO...
December 20, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29262487/-the-effect-of-pre-pregnancy-weight-and-the-increase-of-gestational-weight-on-fetal-growth-restriction-a-cohort-study
#19
M Y Shi, Y F Wang, K Huang, S Q Yan, X Ge, M L Chen, J H Hao, S L Tong, F B Tao
Objective: To investigate the effect of pre-pregnancy weight and the increase of gestational weight on fetal growth restriction. Methods: From May 2013 to September 2014, a total of 3 474 pregnant women who took their first antenatal care and willing to undergo their prenatal care and delivery in Ma 'anshan Maternity and Child Care Centers were recruited in the cohort study. Excluding subjects without weight data before delivery (n=54), pregnancy termination (n=162), twins live births (n=39), without fetal birth weight data (n=7), 3 212 maternal-singleton pairs were enrolled for the final data analysis...
December 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29250184/imbalance-in-circulatory-inkt-th17-and-t-regulatory-cell-frequencies-in-patients-with-b-cell-non-hodgkin-s-lymphoma
#20
Iwona Hus, Agnieszka Bojarska-Junak, Marzena Kamińska, Aneta Dobrzyńska-Rutkowska, Karolina Szatan, Agnieszka Szymczyk, Bożena Kukiełka-Budny, Dariusz Szczepanek, Jacek Roliński
T cells are important in B-cell non-Hodgkin's lymphoma immunity, however the function of T cell subsets, including natural killer (iNKT), T helper (Th)17, and T regulatory cells remains to be elucidated. The present study analyzed the frequencies of iNKT, Th17 and T regulatory cells in the peripheral blood of 41 patients with B-cell non-Hodgkin lymphoma at diagnosis, then during and following immunochemotherapy R-CHOP/R-CVP. At lymphoma diagnosis, iNKT and Th17 frequencies were decreased and T regulatory cell frequencies were increased compared with healthy control group...
December 2017: Oncology Letters
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