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https://www.readbyqxmd.com/read/29150927/identification-of-proteins-drying-oils-waxes-and-resins-in-the-works-of-art-micro-samples-by-chromatographic-and-mass-spectrometric-techniques
#1
Bartłomiej Witkowski, Anna Duchnowicz, Monika Ganeczko, Agnieszka Laudy, Tomasz Gierczak, Magdalena Biesaga
Simplified method for simultaneous identification of proteins, drying oils, waxes and resins in the works-of-art samples was developed. Liquid chromatography with mass spectrometry and gas chromatography with mass spectrometry were used to identify natural materials most frequently encountered in historical paintings. Protein binders were extracted with ammonia and purified using miniaturized solid-phase microextraction (Omix tips) to efficiently suppress matrix interferences. Zwitterionic stationary phase was used for separation of sixteen underivatized amino acids analysis with hydrophilic interaction liquid chromatography that were subsequently quantified with liquid chromatography with mass spectrometry...
November 18, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29150834/il-22-neutralizing-autoantibodies-impair-fungal-clearance-in-murine-oropharyngeal-candidiasis-model
#2
Rudolf Bichele, Jaanika Kärner, Kai Truusalu, Imbi Smidt, Reet Mändar, Heather R Conti, Sarah L Gaffen, Pärt Peterson, Martti Laan, Kai Kisand
Protection against mucocutaneous candidiasis depends on the T helper (Th)17 pathway, as gene defects affecting its integrity result in inability to clear Candida albicans infection on body surfaces. Moreover, autoantibodies neutralizing Th17 cytokines have been related to chronic candidiasis in a rare inherited disorder called autoimmune polyendocriopathy candidiasis ectodermal dystrophy (APECED) caused by mutations in autoimmune regulator (AIRE) gene. However, the direct pathogenicity of these autoantibodies has not yet been addressed...
November 17, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29150715/interleukin-33-promotes-helper-t-cell-type-2-17-inflammation-in-children-with-allergic-rhinitis
#3
Yuanming Wang, Chuling Li, Xianglin Luo, Deyu Xu, Yaxiong Xu, Guanquan Li, Fang Liao, Shujuan Tan
OBJECTIVES: Interleukin-33 is a recently described cytokine which involved in helper T cell type-2 (Th2) mediated diseases. However, its regulatory effect in the pathogenesis of children allergic rhinitis (AR) needs to be further characterized. This study aims to evaluate the expression and role of IL-33 in children with AR. METHODS: Forty children with AR and twenty normal controls were included. IL-33 and Th cytokine production in serum and nasal lavage was examined by immunosorbent assay (ELISA), respectively...
November 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29149780/interleukin-37-relieves-allergic-inflammation-in-a-house-dust-mite-allergic-rhinitis-murine-model
#4
Do Hyun Kim, Si Won Kim, Soo Whan Kim, Jun-Myung Kang
The purpose of this study was to investigate the effects of interleukin-37 (IL-37) on a Dermatophagoides farinae (Der f)-induced murine model of allergic rhinitis (AR). BALB/c mice, except the control groups, were sensitized intraperitoneally and challenged intranasally with Der f (Der f group). The IL-37 and IL-37+anti-CD25 groups were administered IL-37 intranasally. The IL-37+anti-CD25 groups were administered anti-CD25 monoclonal antibody intraperitoneally before challenge. Allergic symptoms and the average eosinophil number were counted...
October 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29145862/l161982-alleviates-collagen-induced-arthritis-in-mice-by-increasing-treg-cells-and-down-regulating-interleukin-17-and-monocyte-chemoattractant-protein-1-levels
#5
Liang Chen, Xianglei Wu, Jun Zhong, Dongqing Li
BACKGROUND: To investigate the effects and potential mechanism of L161982 (a kind of EP4 antagonist) on the collagen-induced arthritis (CIA) mice model. METHODS: The CIA mice model were first established by immunizing with Chicken Type II Collagen on DBA/1 mice. The CIA groups were administered once a day for 2 weeks with either 5 mg/kg L161982 by intraperitoneal injections (IP), 200 U celecoxib by intragastrical injections, or 100 μl PBS (IP). At the end of the study, total arthritis score and histopathologic examination were assessed to determine CIA severity...
November 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29137030/emergency-obstetric-hysterectomy-for-life-threatening-postpartum-hemorrhage-a-12-year-review
#6
Yulong Zhang, Jianying Yan, Qing Han, Tingting Yang, Lihong Cai, Yuelin Fu, Xiaolu Cai, Meimei Guo
The aim of the study was to review the operative experiences of emergency hysterectomy for life-threatening postpartum hemorrhage (PPH) performed over a 12-year period at Fujian Provincial Maternity and Children's Hospital; to examine the incidence and risk factors for emergency obstetric hysterectomy; and to evaluate the curative effectiveness and safety of subtotal hysterectomy for life-threatening PPH.The records of all cases of emergency obstetric hysterectomy performed at Fujian Maternity and Children Health Hospital between January 2004 and June 2016 were analyzed...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29132839/inferior-vena-cava-filters-in-patients-with-acute-pulmonary-embolism-and-cancer
#7
Paul D Stein, Fadi Matta, Frank R Lawrence, Mary J Hughes
BACKGROUND: Administrative data has shown a lower mortality in hospitalized patients with pulmonary embolism and cancer who receive a vena cava filter. In the absence of a randomized controlled trial of vena cava filters in such patients, further investigation is necessary. Therefore, we performed this investigation using administrative data from a different database than used previously, and we investigate patients hospitalized in more recent years. METHODS: We analyzed administrative data from the Premier Healthcare Database, 2010-2014, in patients hospitalized with pulmonary embolism and solid malignant tumors...
November 10, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29132262/diastolic-dysfunction-is-common-in-survivors-of-pediatric-differentiated-thyroid-carcinoma
#8
Mariëlle Sanne Klein Hesselink, Gianni Bocca, Yoran M Hummel, Adrienne H Brouwers, Johannes G M Burgerhof, Eveline W C M van Dam, Jourik A Gietema, Bas Havekes, Marry M van den Heuvel-Eibrink, Eleonora P M Corssmit, Leontien Kremer, Romana Netea-Maier, Helena J H van der Pal, Robin Peeters, John Th M Plukker, Cécile M Ronckers, Hanneke M van Santen, Peter van der Meer, Thera P Links, Wim J E Tissing
INTRODUCTION: Whether pediatric patients with differentiated thyroid carcinoma (DTC) are at risk of developing treatment-related adverse effects on cardiac function is unknown. We therefore studied in long-term survivors of pediatric DTC the prevalence of cardiac dysfunction and atrial fibrillation (AF) in relation to treatment variables, and the association between cardiac dysfunction and plasma biomarkers. PATIENTS AND METHODS: In this nationwide prospective multicenter study, cardiac assessments were performed in 66 adult survivors of pediatric DTC (age at diagnosis ≤18 years and follow-up ≥5 years after diagnosis) treated in The Netherlands between 1970 and 2009...
November 13, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29128761/inborn-errors-of-immunity-underlying-fungal-diseases-in-otherwise-healthy-individuals
#9
REVIEW
Juan Li, Donald C Vinh, Jean-Laurent Casanova, Anne Puel
It has been estimated that there are at least 1.5 million fungal species, mostly present in the environment, but only a few of these fungi cause human disease. Most fungal diseases are self-healing and benign, but some are chronic or life-threatening. Acquired and inherited defects of immunity, including breaches of mucocutaneous barriers and circulating leukocyte deficiencies, account for most severe modern-day mycoses. Other types of infection typically accompany these fungal infections. More rarely, severe fungal diseases can strike otherwise healthy individuals...
November 9, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29125102/role-of-methylprednisolone-in-treatment-of-spinal-cord-injured-with-bone-marrow-mesenchymal-stem-cells-transplantation-in-rats-and-its-effect-on-the-expressions-of-tumor-necrosis-factor-%C3%AE-and-interleukin-1%C3%AE
#10
Xin-Ming Yang, Yao-Yu Cheng, Zhen-Liang Zhang, Cong Kang
Objective To investigate the role of methylprednisolone (MP) in treatment of spinal cord injured (SCI) with bone marrow mesenchymal stem cells (BMSCs) transplantation in rats and its effect on the expressions of tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) at the local tissues.Methods Forty male Sprague-Dawley(SD) rats were used to establish the models of SCI according to the modified Allen's contusion method and then divided into four groups (n=10 in each group) by using random numbers table:MP group,BMSCs group,BMSCs+MP group,and control group...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29114191/cardiac-autonomic-neuropathy-in-type-2-diabetes-mellitus-using-bellavere-s-score-system
#11
Azhar Memon
Objective: Determine the frequency of cardiac autonomic neuropathy (CAN) in type 2 diabetics using Bellavere's score system. Subjects and Methods: The present cross-sectional study was conducted at the Department of Medicine, Isra University Hospital Hyderabad from March to November 2011. Sixty voluntary participants of type 2 diabetes mellitus (DM) were selected through non-probability purposive sampling. Cardiac autonomic nerve function was assessed using Bellavere's score system...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29113703/similar-2-point-discrimination-and-stereognosia-but-better-locognosia-at-long-term-with-an-independent-home-based-sensory-reeducation-program-vs-no-reeducation-after-low-median-nerve-transection-and-repair
#12
Dimitrios K Antonopoulos, Andreas F Mavrogenis, Panayiotis D Megaloikonomos, Evanthia Mitsiokapa, George Georgoudis, Christos Th Vottis, George K Antonopoulos, Panayiotis J Papagelopoulos, Spyridon Pneumatikos, Sarantis G Spyridonos
STUDY DESIGN: Prospective controlled study. INTRODUCTION: Previous studies evaluated the effectiveness of sensory reeducation (SR) after peripheral nerve injury and repair. However, evidence for long-term clinical usefulness of SR is inconclusive. PURPOSE OF THE STUDY: The purpose of this study is to compare the sensory results of patients with low-median nerve complete transection and microsurgical repair, with and without SR at long term...
November 4, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29111279/glycosylated-hemoglobin-level-may-predict-the-severity-of-gastroparesis-in-diabetic-patients
#13
Manhal Izzy, Mindy Lee, Krysta Johns-Keating, Faraj Kargoli, Steven Beckoff, Kwang Chun, Aaron Tokayer
AIM: To investigate the association between glycemic control represented by glycated hemoglobin (HbA1c) level and the value of 4-h gastric retention on nuclear scan. METHODS: We retrospectively reviewed records of diabetic patients who had 4-h nuclear gastric emptying study, with documented 4-h retention value, between January 1st, 2002 and July 30th, 2014 and had HbA1C level close to the time of the study. We divided our cohort into patients with good glycemic control (HbA1C <7, group A), fair control (7-9, group B), and poor control (>9, group C)...
October 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29110844/genetic-polymorphisms-and-lung-cancer-risk-evidence-from-meta-analyses-and-genome-wide-association-studies
#14
REVIEW
Caiyang Liu, Huijie Cui, Dongqing Gu, Min Zhang, Yanfei Fang, Siyu Chen, Mingshuang Tang, Ben Zhang, Huanwen Chen
A growing number of studies investigating the association between Single Nucleotide Polymorphisms (SNPs) and lung cancer risk have been published since over a decade ago. An updated integrative assessment on the credibility and strength of the associations is required. We searched PubMed, Medline, and Web of Science on or before August 29(th), 2016. A total of 198 articles were deemed eligible for inclusion, which addressed the associations between 108 variants and lung cancer. Among the 108 variants, 63 were reported to be significantly associated with lung cancer while the remaining 45 were reported non-significant...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29109671/the-role-and-characteristics-of-collections-of-folk-recepies-in-the-folk-and-traditional-medicine-of-bosnia-and-herzegovina
#15
REVIEW
Armin Skrbo, Izet Masic
Introduction: Folk medicine represents part of the folk culture, when we first think about the rural culture with characteristic of the rural population in the pre-industrial period. The difference between official and folk medicine is manifested in the education, knowledge and social status of those practicing folk medicine as well as their patients. The most common ways of treating were the treatment by use of herbs, magic and treatments based on religious beliefs. So, it is of no surprise that folk medicine was the main form of treatment for the inhabitants of Bosnia and Herzegovina (B&H) in the past...
September 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/29107298/klk5-induces-shedding-of-dpp4-from-circulatory-th17-cells-in-type-2-diabetes
#16
Titli Nargis, Krishna Kumar, Amrit Raj Ghosh, Amit Sharma, Dipayan Rudra, Debrup Sen, Saikat Chakrabarti, Satinath Mukhopadhyay, Dipyaman Ganguly, Partha Chakrabarti
OBJECTIVE: Increasing plasma levels and activity of dipeptidyl peptidase-4 (DPP4 or CD26) are associated with rapid progression of metabolic syndrome to overt type 2 diabetes mellitus (T2DM). While DPP4 inhibitors are increasingly used as anti-hyperglycemic agents, the reason for the increase in plasma DPP4 activity in T2DM patients remains elusive. METHODS: We looked into the source of plasma DPP4 activity in a cohort of 135 treatment naive nonobese (BMI < 30) T2DM patients...
November 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29105464/-study-on-cellular-immunity-mechanisms-of-suspended-moxibustion-for-treating-neutrophilic-asthma-in-rats
#17
Wei Zhang, Bin Yao, Hui-Ming Cheng, Fan-Lei Meng
OBJECTIVE: To observe the influence of suspended moxibustion on neutrophilic asthma related signal factors in asthma rats. METHODS: Thirty-two SD rats were randomly divided into normal control, model, dexamethasone(DEX) and suspended moxibustion (MOX) groups, with 8 rats in each group. The neutrophil granulocyte asthma model was made by intranasal instillation of lipopolysaccharide (LPS), intraperitoneal injection of ovalbumin(OVA) and inhalation of OVA, once a day for 14 d...
October 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29101111/the-interleukin-il-23-t-helper-th-17-axis-in-experimental-autoimmune-encephalomyelitis-and-multiple-sclerosis
#18
Michael Hiltensperger, Thomas Korn
T helper (Th)17 cells are responsible for host defense against fungi and certain extracellular bacteria but have also been reported to play a role in a variety of autoimmune diseases. Th17 cells respond to environmental cues, are very plastic, and might also be involved in tissue homeostasis and regeneration. The imprinting of pathogenic properties in Th17 cells in autoimmunity seems highly dependent on interleukin (IL)-23. Since Th17 cells were first described in experimental autoimmune encephalomyelitis, they have been suggested to also promote tissue damage in multiple sclerosis (MS)...
November 3, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29093649/il-17a-producing-foxp3-regulatory-t-cells-and-human-diseases
#19
REVIEW
Min Kyung Jung, Jeong-Eun Kwak, Eui-Cheol Shin
CD4(+)Foxp3(+) regulatory T (Treg) cells play major roles in immune homeostasis. While CD4(+)Foxp3(+) Treg cells act to suppress other immune effector cells, there is growing evidence that they also produce pro-inflammatory cytokines, such as IL-17A, in inflammatory conditions. The pro-inflammatory cytokine milieu, toll-like receptor (TLR) signaling, and specific transcription factors are important for the production of IL-17A by CD4(+)Foxp3(+) Treg cells. In particular, IL-17A-producing CD4(+)Foxp3(+) Treg cells express RORγt, the T helper (Th) 17-specific transcription factor, in addition to Foxp3...
October 2017: Immune Network
https://www.readbyqxmd.com/read/29090478/reliability-of-an-adherence-monitoring-sensor-embedded-in-an-oral-appliance-used-for-treatment-of-obstructive-sleep-apnea
#20
K Gjerde, S Lehmann, I F Naterstad, M E Berge, A Johansson
The aim of this study was to test if digitally registered use of a Mandibular Advancement Device (MAD) by a built-in thermal sensor was reliable compared to a self-reported diary of MAD use. Eighty consecutive patients referred to a specialist outpatient sleep medicine clinic (HUS) were recruited. Patients of both genders aged from 25 to 70 years with a diagnosis of mild to moderate or severe OSA, were included. All participants signed a written informed consent when they received the MAD. For the purpose of this reliability study, we found it sufficient to include the first 30 nights of MAD use in the reliability analysis...
November 1, 2017: Journal of Oral Rehabilitation
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