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https://www.readbyqxmd.com/read/29773890/intraperitoneal-administration-of-the-anti-il-23-antibody-prevents-the-establishment-of-intestinal-nematodes-in-mice
#1
M Gomez-Samblas, D Bernal, A Bolado-Ortiz, S Vilchez, F Bolás-Fernández, A M Espino, M Trelis, A Osuna
Previous studies have established that an increased Th-9 response creates a hostile environment for nematode parasites. Given that IL-23, a cytokine required for maintenance of the IL-17-secreting phenotype, has inhibitory effects on IL-9 production, we hypothesized that reducing circulating IL-23 by treatment with anti-IL-23 antibodies would reduce the establishment and development of parasitic intestinal nematodes. In this study, we show that animals treated with anti-IL-23 monoclonal antibodies showed a drastic reduction in the number of mouse pinworms (Aspiculuris tetraptera) recovered from the intestine (p < 0...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29770140/seventeen-year-journey-working-with-a-master
#2
Jinfang Zhu
It had been a great honor for me to work with the late Dr. William E. Paul for 17 years in the Laboratory of Immunology (LI) from 1998 until his passing in 2015. He was such a master in the immunology field. Under his outstanding guidance, my research has been focusing on transcriptional regulation of T helper (Th) cell differentiation, especially, on the role of a master transcription factor GATA3 during Th2 cell differentiation. Just as enormous scientific contributions of Dr. Paul (we all call him Bill) to the immunology community are far beyond his serving as the Chief of the LI, GATA3 also plays important roles in different lymphocytes at various developmental stages besides its critical functions in Th2 cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29767465/salt-inflammation-il-17-and-hypertension
#3
REVIEW
Ulrich O Wenzel, Marlies Bode, Christian Kurts, Heimo Ehmke
Traditionally, arterial hypertension and subsequent end-organ damage have been attributed to hemodynamic factors, but increasing evidence indicates that inflammation also contributes to the deleterious consequences of this disease. The immune system has evolved to prevent invasion of foreign microorganisms and to promote tissue healing after injury. However, this beneficial activity comes at a cost of collateral damage when the immune system overreacts to internal injury, such as prehypertension. Over the last years important findings have revolutionized hypertension research...
May 16, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29760713/human-leukocyte-antigen-class-i-alleles-and-the-autoreactive-t-cell-response-in-psoriasis-pathogenesis
#4
REVIEW
Jörg Christoph Prinz
Psoriasis is a complex immune-mediated inflammatory skin disease characterized by T-cell-driven epidermal hyperplasia. It occurs on a strong genetic predisposition. The human leukocyte antigen (HLA)-class I allele HLA-C*06:02 on psoriasis susceptibility locus 1 (PSORS1 on 6p21.3) is the main psoriasis risk gene. Other HLA-class I alleles encoding HLA molecules presenting overlapping peptide repertoires show associations with psoriasis as well. Outside the major histocompatibility complex region, genome-wide association studies identified more than 60 psoriasis-associated common gene variants exerting only modest individual effects...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29758111/genetic-profiles-of-transcriptomic-clusters-of-childhood-asthma-determine-specific-severe-subtype
#5
Y-L Yeh, M-W Su, B-L Chiang, Y-H Yang, C-H Tsai, Y L Lee
BACKGROUND: Previous studies have defined transcriptomic subtypes of adult asthma using samples of induced sputum and bronchial epithelium; however, those procedures are not readily applicable in the clinic, especially for childhood asthma. OBJECTIVE: We aim to dissect the transcriptomic clusters of childhood asthma using highly variably expressed genes of peripheral blood mononuclear cells (PBMC) among patients. METHODS: Gene expression of PBMC from 133 asthmatic children and 11 healthy controls was measured with Illumina microarrays...
May 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29758052/decreased-circulating-t-regulatory-lymphocytes-in-obese-patients-undergoing-bariatric-surgery
#6
Claudia Agabiti-Rosei, Valentina Trapletti, Silvia Piantoni, Paolo Airò, Angela Tincani, Carolina De Ciuceis, Claudia Rossini, Francesco Mittempergher, Amin Titi, Nazario Portolani, Stefano Caletti, Maria Antonietta Coschignano, Enzo Porteri, Guido A M Tiberio, Paola Pileri, Leonardo Solaini, Rajesh Kumar, Silvia Ministrini, Enrico Agabiti Rosei, Damiano Rizzoni
OBJECTIVE: It has been previously demonstrated that T lymphocytes may be involved in the development of hypertension and microvascular remodeling, and that circulating T effector lymphocytes may be increased in hypertension. In particular, Th1 and Th 17 lymphocytes may contribute to the progression of hypertension and microvascular damage while T-regulatory (Treg) lymphocytes seem to be protective in this regard. However, no data is available about patients with severe obesity, in which pronounced microvascular alterations were observed...
2018: PloS One
https://www.readbyqxmd.com/read/29757590/imbalance-of-peripheral-blood-t-helper-type-17-responses-in-patients-with-vitiligo
#7
Farinaz Behfarjam, Parvine Mansouri, Zohreh Jadali
There is growing evidence to suggest that Th cells play pivotal roles in a variety of chronic inflammatory diseases, including vitiligo. However, the exact role of different subsets of Th cells in the pathogenesis of vitiligo is still a question. The purpose of present study was to determine the mRNA expression level of Th17 master transcription factor retinoic acid receptor-related orphan receptors gamma (RORɣt) and cytokine mRNA and protein expression profiles of Th17 cells. 22 patients with vitiligo and 22 normal subjects were enrolled in the study...
April 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29757188/microrna-210-overexpression-promotes-psoriasis-like-inflammation-by-inducing-th1-and-th17-cell-differentiation
#8
Ruifang Wu, Jinrong Zeng, Jin Yuan, Xinjie Deng, Yi Huang, Lina Chen, Peng Zhang, Huan Feng, Zixin Liu, Zijun Wang, Xiaofei Gao, Haijing Wu, Honglin Wang, Yuwen Su, Ming Zhao, Qianjin Lu
Immune imbalance of T lymphocyte subsets is a hallmark of psoriasis, but the molecular mechanisms underlying this aspect of psoriasis pathology are poorly understood. Here, we report that microRNA-210 (miR-210), a miR that is highly expressed in both psoriasis patients and mouse models, induces helper T (Th) 17 and Th1 cell differentiation but inhibits Th2 differentiation through repressing STAT6 and LYN expression, contributing to several aspects of the immune imbalance in psoriasis. Both miR-210 ablation in mice and inhibition of miR-210 by intradermal injection of antagomir-210 blocked the immune imbalance and the development of psoriasis-like inflammation in an imiquimod-induced or IL-23-induced psoriasis-like mouse model...
May 14, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29747748/pg201-protects-mice-from-experimental-autoimmune-encephalomyelitis-via-suppression-of-effector-t-cell-activation
#9
Min-Jung Bae, Jinyong Choi, Hyun-Keun Kim, Seonung Lim, Sunyoung Kim
BACKGROUND: PG201 is a botanical formulation, approved as an ethical drug (ETC) phytomedicine for treatment of patients with osteoarthritis in Korea, following satisfactory phase II and phase III studies. This phytomedicine was previously been shown to possess significant anti-inflammatory activities, presumably via the control of Th1 and Th17 cells in animal models and in vitro cell culture systems. PURPOSE: In this study, the possibility of using PG201 to treat multiple sclerosis was explored...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29747276/-relationship-between-vertebral-ct-values-and-bone-mineral-density-in-patients-with-chronic-obstructive-pulmonary-disease
#10
K Li, P Wang, R Y Yan, S J Song
Objective: To explore a simple method for early detection of osteoporosis in patients with chronic obstructive pulmonary disease (COPD), by analyzing the correlation between computed tomography (CT) values of the thoracolumbar vertebrae and dual energy X ray absorptiometry (DXA). Methods: 86 patients with acute exacerbation of COPD were included in this study. The average age of the patients, including 57 males and 29 females, was 74±10 years. They all received chest CT and DXA examination within 1 month after admission...
May 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29740348/could-sodium-chloride-be-an-environmental-trigger-for-immune-mediated-diseases-an-overview-of-the-experimental-and-clinical-evidence
#11
REVIEW
Eric Toussirot, Matthieu Béreau, Charline Vauchy, Philippe Saas
Immune mediated diseases (IMDs) are complex chronic inflammatory diseases involving genetic and environmental factors. Salt intake has been proposed as a diet factor that can influence the immune response. Indeed, experimental data report the influence of sodium chloride on the differentiation of naive CD4+ T cells into IL-17 secreting T helper (Th) cells (Th17 cells), by a mechanism involving the serum glucocorticoid kinase-1 (SGK1) that promotes the expression of the IL-23 receptor (IL-23R). The IL-23/IL-23R is critical for pathogenic inflammatory Th17 cell differentiation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29736149/interleukin-17-and-interleukin-23-levels-in-gingival-crevicular-fluid-of-patients-with-chronic-and-aggressive-periodontitis
#12
Rokhsareh Sadeghi, Mandana Sattari, Fatemeh Dehghan, Solmaz Akbari
Introduction: Interleukin-17 is a pro-inflammatory cytokine with a wide range of protective and destructive effects in periodontitis. The role of IL-23 is stabilisation and expansion of Th-17. The aim of this study was to assess whether patients with aggressive and chronic periodontitis exhibit different gingival crevicular fluid (GCF) concentrations of IL-17 and IL-23 compared with clinically healthy subjects. Material and methods: GCF samples were obtained from 32 patients: 10 with chronic periodontitis (CP), 12 with aggressive periodontitis (AgP), and 10 healthy controls (HC)...
2018: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29732512/trace-elements-concentration-and-distributions-in-coal-and-coal-mining-wastes-and-their-environmental-and-health-impacts-in-shaanxi-china
#13
Rahib Hussain, Kunli Luo, Zhao Chao, Zhao Xiaofeng
This study probe the probable impacts of coal mining pollution and its impacts on human's health and environment. A total of 144 samples including coal and coal wastes, soil, plants, foods, and water were collected from the Hancheng county and countryside of Shaanxi, China. All the samples were analyzed for trace elements using ICP-MS, OES, and AFS. Results showed that the concentration of Se, As, Cr, Cu, Pb, Cd, Co, Ni, Mo, U, Th (mgKg-1 ), Fe, Mn, Al, Ti (%) etc., in coal and coal wastes were 7.5, 12.1, 275, 55, 54...
May 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29731755/expression-and-function-of-il12-23-related-cytokine-subunits-p35-p40-and-p19-in-giant-cell-arteritis-lesions-contribution-of-p40-to-th1-and-th17-mediated-inflammatory-pathways
#14
Georgina Espígol-Frigolé, Ester Planas-Rigol, Ester Lozano, Marc Corbera-Bellalta, Nekane Terrades-García, Sergio Prieto-González, Ana García-Martínez, Jose Hernández-Rodríguez, Josep M Grau, Maria C Cid
Background: Giant-cell arteritis (GCA) is considered a T helper (Th)1- and Th17-mediated disease. Interleukin (IL)-12 is a heterodimeric cytokine (p35/p40) involved in Th1 differentiation. When combining with p19 subunit, p40 compose IL-23, a powerful pro-inflammatory cytokine that maintains Th17 response. Objectives: The aims of this study were to investigate p40, p35, and p19 subunit expression in GCA lesions and their combinations to conform different cytokines, to assess the effect of glucocorticoid treatment on subunit expression, and to explore functional roles of p40 by culturing temporal artery sections with a neutralizing anti-human IL-12/IL-23p40 antibody...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29731129/early-onset-pediatric-atopic-dermatitis-is-characterized-by-t-h-2-t-h-17-t-h-22-centered-inflammation-and-lipid-alterations
#15
Patrick M Brunner, Ariel Israel, Ning Zhang, Alexandra Leonard, Huei-Chi Wen, Thy Huynh, Gary Tran, Sarah Lyon, Giselle Rodriguez, Supriya Immaneni, Annette Wagner, Xiuzhong Zheng, Yeriel D Estrada, Hui Xu, James G Krueger, Amy S Paller, Emma Guttman-Yassky
BACKGROUND: Although atopic dermatitis (AD) often starts in early childhood, detailed tissue profiling of early-onset AD in children is lacking, hindering therapeutic development for this patient population with a particularly high unmet need for better treatments. OBJECTIVE: We sought to globally profile the skin of infants with AD compared with that of adults with AD and healthy control subjects. METHODS: We performed microarray, RT-PCR, and fluorescence microscopy studies in infants and young children (<5 years old) with early-onset AD (<6 months disease duration) compared with age-matched control subjects and adults with longstanding AD...
April 19, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29730558/increased-expression-of-il-1r8-and-a-possible-immunomodulatory-role-of-its-ligand-il-37-in-allergic-rhinitis-patients
#16
Cong Li, Yang Shen, Jue Wang, Zu-Xia Ma, Xia Ke, Zhi-Hai Wang, Su-Ling Hong, Guo-Hua Hu
Allergic rhinitis (AR) is a chronic inflammatory airway disease that is caused by an abnormal T cell response. T helper (Th)-17 cells and Th2 cells are the CD4+ T cell subsets implicated in the pathogenesis of AR. The suppression of excessive responses of these Th17 and Th2 cells has been reported to be an effective therapeutic approach to treat AR patients, and continuous efforts are being undertaken to find new methods to modulate the function of these cells. Recent studies have shown that IL-1R8 and its ligand IL-37 negatively regulate the immune response...
May 3, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29728642/a-model-of-th17-associated-ileal-hyperplasia-that-requires-both-il-17a-and-ifn%C3%AE-to-generate-self-tolerance-and-prevent-colitis
#17
Jonathan C Jeschke, Christopher G Mayne, Jennifer Ziegelbauer, Christopher L DeCiantis, Selina Singh, Suresh N Kumar, Mariko Suchi, Yoichiro Iwakura, William R Drobyski, Nita H Salzman, Calvin B Williams
Homeostasis in the ileum, which is commonly disrupted in patients with Crohn's disease, involves ongoing immune responses. To study how homeostatic processes of the ileum impact CD4+ T cell responses, we used TCR transgenic tools to breed mice that spontaneously produced CD4+ T cells reactive to an antigen expressed in the ileum. At an early age, the ilea of these mice exhibit crypt hyperplasia and accumulate increased numbers of TH 17 cells bearing non-transgenic clonotypes. Half of these mice subsequently developed colitis linked to broad mucosal infiltration by TH 17 and TH 1 cells expressing non-transgenic clonotypes, chronic wasting disease and loss of ileal crypt hyperplasia...
May 4, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29718698/placental-ischemia-stimulated-t-helper-17-cells-induce-preeclampsia-associated-cytolytic-natural-killer-cells-during-pregnancy
#18
Corbin A Shields, Maggie McCalmon, Tarek Ibrahim, Dakota L White, Jan Michael Williams, Babbette D LaMarca, Denise C Cornelius
Previous studies have demonstrated that T-helper 17 cells (TH 17s) and cytolytic NK cells (cNKs) are increased in women with preeclampsia (PE). In this study, we investigated the role of placental ischemia-stimulated TH 17s to induce cNKs in pregnancy. We further assessed the role of TH 17-mediated oxidative stress to facilitate cNK activation in pregnancy by treating with the SOD mimetic tempol. CD4+ /CD25- cells were isolated from reduced uterine perfusion pressure (RUPP) rats and differentiated into TH 17 cells in vitro...
May 2, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29710675/analysis-of-th22-th17-and-cd4-cells-co-producing-il-17-il-22-at-different-stages-of-human-colon-cancer
#19
Hassan Doulabi, Maryam Rastin, Hossein Shabahangh, Ghodratollah Maddah, Abbas Abdollahi, Reza Nosratabadi, Seyed-Alireza Esmaeili, Mahmoud Mahmoudi
T-helper (Th) 22 cells are involved in the immunopathogenesis of inflammatory diseases, but their specific role in the immunopathogenesis of cancer is unknown. In this study, we examined the profile of circulating and intratumoral Th17, Th22 and CD4+ cells co-producing IL-17/IL-22 in colon cancer (CC) patients in relation to tumor staging. Thirty newly diagnosed colon cancer (CC) patients participated in this study. The percentage of Th1 (CD4+ IFN-γ+ IL-17- IL-22- ), Th17 (CD4+ IFN-γ- IL-17+ IL-22- ), Th22 (CD4+ IFN-γ- IL-17- IL-22+ ) and CD4+ cells co-producing IL-17/IL-22 (CD4+ IFN-γ- IL-17+ IL-22+ ) in the peripheral blood, tumor and paratumor tissues was assessed by multicolor flow cytometry...
April 26, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29706769/proceedings-of-the-17-th-international-congress-of-myriapodology-krabi-thailand
#20
EDITORIAL
Pavel Stoev, Gregory Edgecombe D
No abstract text is available yet for this article.
2018: ZooKeys
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