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https://www.readbyqxmd.com/read/28425862/the-impact-of-il-17-in-atherosclerosis
#1
Xinjie Lu
Atherosclerosis is a chronic vascular disease in which atherosclerotic plaques develop in the arterial wall. It is believed that inflammation plays a major role in atherosclerotic formation and progression. Thus, atherosclerosis can be considered as an inflammatory disease of the arterial vessel. Mouse model demonstrated that T and B cell deficiency reduces the atherosclerotic burden in the formation of an atherosclerotic lesion. CD4+ T helper cells (Th), such as Th1 cells known being the major CD4+ T cell subtype found in mouse models of atherogenesis, increase plaque formation caused by oxLDL...
April 19, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28424959/non-essential-element-concentrations-in-brown-grain-rice-assessment-by-advanced-data-mining-techniques
#2
Roxana Villafañe, Melisa Hidalgo, Analía Piccoli, Eduardo Marchevsky, Roberto Pellerano
The concentrations of 17 non-essential elements (Al, As, Ba, Be, Cd, Ce, Cr, Hg, La, Li, Pb, Sb, Sn, Sr, Th, Ti, and Tl) were determined in brown grain rice samples of two varieties: Fortuna and Largo Fino. The samples were collected from the four main producing regions of Corrientes province (Argentina). Quantitative determinations were performed by inductively coupled plasma mass spectrometry (ICP-MS), using a validated method. The contents of As, Be, Cd, Ce, Cr, Hg, Pb, Sb, Sn, Th, and Tl were very low or not detected in most samples...
April 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28412610/overexpression-and-varied-clinical-significance-of-th9-versus-th17-cells-in-distinct-subtypes-of-oral-lichen-planus
#3
Hui Wang, Jingping Bai, Zhenhua Luo, Jie Fu, Hongjian Wang, Zheng Sun
OBJECTIVE: Oral lichen planus (OLP) presents with large numbers of T lymphocytes accumulating beneath the epithelium of the oral mucosa; however, its aetiology remains obscure. A potential role for an emerging novel T cell subset, Th9, in OLP has recently been suggested but remains to be clarified. The current aim was to investigate the expression and potential clinical significance of Th9 cells in distinct subtypes of OLP. MATERIALS AND METHODS: Peripheral blood samples were collected from 41 OLP patients and 18 healthy controls (HCs)...
April 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28402963/identification-of-serum-inflammatory-markers-as-classifiers-of-lung-cancer-mortality-for-stage-i-adenocarcinoma
#4
Claire L Meaney, Adriana Zingone, Derek Brown, Yunkai Yu, Liang Cao, Bríd M Ryan
BACKGROUND: Lung cancer is the leading cause of cancer-related mortality worldwide. Low-dose CT (LDCT) imaging is now recommended to screen high-risk lung cancer individuals in the USA. LDCT has resulted in increased detection of stage I lung cancer for which the current standard of care is surgery alone. However, approximately 30% of these patients develop recurrence and therefore are in need of further treatment upon diagnosis. This study aims to explore blood-based inflammatory biomarkers to identify patients at high-risk of mortality for which additional treatment modalities can be offered at time of diagnosis...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28401998/early-discontinuation-of-antiseizure-medications-in-neonates-with-hypoxic-ischemic-encephalopathy
#5
Mark P Fitzgerald, Sudha Kilaru Kessler, Nicholas S Abend
OBJECTIVE: Neonates with hypoxic-ischemic encephalopathy (HIE) managed with therapeutic hypothermia (TH) often experience acute symptomatic seizures, prompting treatment with antiseizure medications (ASMs). Because the risk of seizure occurrence after hospital discharge is unknown, the optimal ASM treatment duration is unclear. We aimed to determine the risk of seizure occurrence after hospital discharge and the impact of ASM treatment duration on this outcome. METHODS: We performed a single-center, retrospective study of consecutive neonates with HIE managed with TH who received ASMs for acute symptomatic seizures from June 2010 through December 2014...
April 12, 2017: Epilepsia
https://www.readbyqxmd.com/read/28401935/unique-invariant-natural-killer-t-cells-promote-intestinal-polyps-by-suppressing-th1-immunity-and-promoting-regulatory-t-cells
#6
Y Wang, S Sedimbi, L Löfbom, A K Singh, S A Porcelli, S L Cardell
CD1d-restricted invariant natural killer T (iNKT) cells are known as potent early regulatory cells of immune responses. Besides the established roles in the regulation of inflammation and autoimmune disease, studies have shown that iNKT cells have important roles in tumor surveillance and the control of tumor metastasis. Here we found that the absence of iNKT cells markedly decreased the total number of intestinal polyps in APC(Min/+) mice, a model for colorectal cancer. Polyp iNKT cells were enriched for interleukin-10 (IL-10)- and IL-17-producing cells, showed a distinct phenotype being CD4(+), NK1...
April 12, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28401558/2016-ranzcog-ian-mcdonald-memorial-oration-the-whole-nine-months-lasts-a-lifetime-delivered-at-ranzcog-annual-scientific-meeting-perth-17-th-october-2016
#7
John P Newnham
No abstract text is available yet for this article.
April 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28395298/cytokines-and-chemokines-involved-in-acute-retinal-necrosis
#8
Lenneke de Visser, Joke H de Boer, Ger T Rijkers, Karin Wiertz, Henk-Jan van den Ham, Rob de Boer, Anton M van Loon, Aniki Rothova, Jolanda D F de Groot-Mijnes
Purpose: To investigate which cytokines and chemokines are involved in the immunopathogenesis of acute retinal necrosis (ARN), and whether cytokine profiles are associated with clinical manifestations, such as visual outcome. Methods: Serum and aqueous humor (AH) samples of 19 patients with ARN were analyzed by multiplex immunoassay. Infectious controls consisted of 18 patients with rubella virus-associated Fuchs' uveitis and 20 patients with ocular toxoplasmosis all confirmed by intraocular fluid analyses...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28394668/use-of-cortisol-and-adrenal-weight-at-pediatric-postmortem
#9
Rebecca Morrison, Jansher Khan, Peter Galloway, Jane McNeilly, Syed Faisal Ahmed, Dawn Penman
We studied the relationship between adrenal weight and postmortem cortisol level in cases of infant death, and examined use of these measurements in adrenal insufficiency. We analyzed procurator-fiscal postmortem reports in the West of Scotland over a three year period. Combined adrenal weight was expressed as percentage of total body weight (%TBW). Of 106 cases, median (5(th), 95(th)) %TBW was 0.056 (0.025, 0.23) and median plasma cortisol was 8.4 ug/dl (1.0, 47.1). There was no correlation between %TBW and plasma cortisol (r = 0...
April 10, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28389986/changes-and-tracking-of-bone-mineral-density-in-late-adolescence-the-troms%C3%A3-study-fit-futures
#10
Ole Andreas Nilsen, Luai Awad Ahmed, Anne Winther, Tore Christoffersen, Anne-Sofie Furberg, Guri Grimnes, Elaine Dennison, Nina Emaus
Areal bone mineral density (aBMD) predicts future fracture risk. This study explores the development of aBMD and associated factors in Norwegian adolescents. Our results indicate a high degree of tracking of aBMD levels in adolescence. Anthropometric measures and lifestyle factors were associated with deviation from tracking. PURPOSE: Norway has one of the highest reported incidences of hip fractures. Maximization of peak bone mass may reduce future fracture risk. The main aims of this study were to describe changes in bone mineral levels over 2 years in Norwegian adolescents aged 15-17 years at baseline, to examine the degree of tracking of aBMD during this period, and to identify baseline predictors associated with positive deviation from tracking...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28387981/evaluation-of-mri-for-diagnosis-of-extraprostatic-extension-in-prostate-cancer
#11
Satheesh Krishna, Christopher S Lim, Matthew D F McInnes, Trevor A Flood, Wael M Shabana, Robert S Lim, Nicola Schieda
PURPOSE: To assess the ability of magnetic resonance imaging (MRI) to diagnose extraprostatic extension (EPE) in prostate cancer. MATERIALS AND METHODS: With Institutional Review Board (IRB) approval, 149 men with 170 ≥0.5 mL tumors underwent preoperative 3T MRI followed by radical prostatectomy (RP) between 2012-2015. Two blinded radiologists (R1/R2) assessed tumors using Prostate Imaging Reporting and Data System (PI-RADS) v2, subjectively evaluated for the presence of EPE, measured tumor size, and length of capsular contact (LCC)...
April 7, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28384358/similarities-in-trabecular-hypertrophy-with-site-specific-differences-in-cortical-morphology-between-men-and-women-with-type-2-diabetes-mellitus
#12
Janina M Patsch, Sazan Rasul, Florian A Huber, Karoline Leitner, Anita Thomas, Roland Kocijan, Stephanie Boutroy, Michael Weber, Heinrich Resch, Franz Kainberger, Claudia Schüller-Weidekamm, Alexandra Kautzky-Willer
The goal of our study was to investigate interactions between sex and type 2 diabetes mellitus (T2DM) with regard to morphology of the peripheral skeleton. We recruited 85 subjects (mean age, 57±11.4 years): women with and without T2DM (n = 17; n = 16); and men with and without T2DM (n = 26; n = 26). All patients underwent high-resolution, peripheral, quantitative, computed tomography (HR-pQCT) imaging of the ultradistal radius (UR) and tibia (UT). Local bone geometry, bone mineral density (BMD), and bone microarchitecture were obtained by quantitative analysis of HR-pQCT images...
2017: PloS One
https://www.readbyqxmd.com/read/28379884/parental-alcohol-consumption-and-risk-of-leukemia-in-the-offspring-a-systematic-review-and-meta-analysis
#13
Maria A Karalexi, Nick Dessypris, Thomas P Thomopoulos, Evangelos Ntouvelis, Maria Kantzanou, Andreas-Antonios Diamantaras, Maria Moschovi, Margarita Baka, Emmanuel Hatzipantelis, Maria Kourti, Sophia Polychronopoulou, Eftichia Stiakaki, Ana-M Mora, Victor Wunsch-Filho, Claire Infante-Rivard, Dimitrios Loutradis, Eleni Th Petridou
Parental alcohol consumption before and during pregnancy has been linked to adverse outcomes in the offspring including leukemogenesis. We, therefore, aimed to systematically assess and quantitatively synthesize published data on the association of paternal consumption during preconception and maternal consumption during pregnancy with leukemia risk in childhood (0-14 years). Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched PubMed (until February 2016) and the reference lists of the relevant studies...
April 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28377586/systemic-frequencies-of-t-helper-1-and-t-helper-17-cells-in-patients-with-age-related-macular-degeneration-a-case-control-study
#14
Amardeep Singh, Yousif Subhi, Marie Krogh Nielsen, Mads Krüger Falk, Sara Maj Hyldig Matzen, Finn Sellebjerg, Torben Lykke Sørensen
Age-related macular degeneration (AMD) is a degenerative disease of the retina and a leading cause of irreversible vision loss. We investigated the systemic differences in the frequency of T helper (Th) 1 and Th17 cells in patients with non-exudative and exudative AMD and compared to age-matched controls. Flow cytometry was used to determine the systemic frequency of Th1 (CD4(+)CXCR3(+)IL12RB2(+)) and Th17 (CD4(+)CCR6(+)IL23R(+)) cells, and percentage of CD4(+) T-cells expressing CXCR3, IL12RB2, CCR6, IL23R, and co-expressing CXCR3 and CCR6...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376739/seroprevalence-of-bordetella-pertussis-antibodies-in-adults-in-hungary-results-of-an-epidemiological-cross-sectional-study
#15
Péter Torzsa, Raghavendra Devadiga, Monica Tafalla
BACKGROUND: Pertussis (whooping cough) is well known to be underreported, particularly among adults, who can act as an infectious reservoir, potentially putting susceptible newborns at risk of serious illness. The purpose of this study was to estimate the seroprevalence of pertussis in adults in Hungary. METHODS: This epidemiological, cross-sectional study was conducted in adults in five general practitioners' practices in Hungary. Serum anti-pertussis toxin immunoglobulin G (anti-PT IgG) antibody levels were analyzed using enzyme-linked immunosorbent assay...
April 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28375426/spatial-conscript-body-height-correlation-of-norwegian-districts-in-the-19-th-century
#16
Dominik Bents, Alexander Rybak, Detlef Groth
Background: We investigated height of Norwegian conscripts in view of the hypothesis of a "community effect on height" using autocorrelation analysis of district heights within a time-span of 20 years at the end of the 19(th) century and correlations between neighboring districts at this time. Material and methods: After digitalizing available body height data of Norwegian draftees in 1877-1878, 1880 (averaged as 1878), and 1895-1897 (averaged as 1896) we calculated the magnitude of autocorrelation of body height within the same municipality at different time points...
April 4, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/28375156/%C3%AF-3-polyunsaturated-fatty-acids-ameliorate-type-1-diabetes-and-autoimmunity
#17
Xinyun Bi, Fanghong Li, Shanshan Liu, Yan Jin, Xin Zhang, Tao Yang, Yifan Dai, Xiaoxi Li, Allan Zijian Zhao
Despite the benefit of insulin, blockade of autoimmune attack and regeneration of pancreatic islets are ultimate goals for the complete cure of type 1 diabetes (T1D). Long-term consumption of ω-3 polyunsaturated fatty acids (PUFAs) is known to suppress inflammatory processes, making these fatty acids candidates for the prevention and amelioration of autoimmune diseases. Here, we explored the preventative and therapeutic effects of ω-3 PUFAs on T1D. In NOD mice, dietary intervention with ω-3 PUFAs sharply reduced the incidence of T1D, modulated the differentiation of Th cells and Tregs, and decreased the levels of IFN-γ, IL-17, IL-6, and TNF-α...
April 4, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28373650/vitamin-d3-inhibits-micro-rna-17-92-to-promote-specific-immunotherapy-in-allergic-rhinitis
#18
Zhi-Jian Yu, Lu Zeng, Xiang-Qian Luo, Xiao-Rui Geng, Rui Xu, Kun Chen, Gui Yang, Xi Luo, Zhi-Qiang Liu, Zhi-Gang Liu, Da-Bo Liu, Ping-Chang Yang, Hua-Bin Li
It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin D3 (VD3) can regulate multiple bioactivities in the body. This study tests a hypothesis that VD3 facilitates the effect of specific immunotherapy (SIT) on Th2 response. We observed that treatment with either SIT or VD3 alleviated AR symptoms as well as reduced serum levels of specific IgE and T helper (Th) 2 cytokines, suppressed miR-19a (one of the members of the miR-17-92 cluster) and increased IL-10 in peripheral B cells, which was further improved in those AR patients treated with both SIT and VD3...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28370300/predictive-validity-of-icd-11-ptsd-as-measured-by-the-impact-of-event-scale-revised-a-15-year-prospective-study-of-political-prisoners
#19
Philip Hyland, Chris R Brewin, Andreas Maercker
The 11(th) edition of the International Classification of Diseases (ICD-11; World Health Organization, 2017) proposes a model of posttraumatic stress disorder (PTSD) that includes 6 symptoms. This study assessed the ability of a classification-independent measure of posttraumatic stress symptoms, the Impact of Event Scale-Revised (Weiss & Marmar, 1996), to capture the ICD-11 model of PTSD. The current study also provided the first assessment of the predictive validity of ICD-11 PTSD. Former East German political prisoners were assessed in 1994 (N = 144) and in 2008-2009 (N = 88) on numerous psychological variables using self-report measures...
March 29, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28369349/genome-sequence-of-a-rice-pest-the-white-backed-planthopper-sogatella-furcifera
#20
Lin Wang, Nan Tang, Xinlei Gao, Zhaoxia Chang, Liqin Zhang, Guohui Zhou, Dongyang Guo, Zhen Zeng, Wenjie Li, Ibukun A Akinyemi, Huanming Yang, Qingfa Wu
Background: Sogatella furcifera is an important phloem sap-sucking and plant virus-transmitting migratory insect of rice. Because of its high reproductive potential, dispersal capability and transmission of plant viral diseases, S. furcifera causes considerable damage to rice grain production and has great economical and agricultural impacts. Comprehensive studies into ecological aspects and virus-host interactions of S. furcifera have been limited because of the lack of a well-assembled genome sequence...
January 1, 2017: GigaScience
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