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https://www.readbyqxmd.com/read/28811790/cardiorespiratory-fitness-and-its-association-with-adiposity-indices-in-young-adults
#1
Mozaffer Rahim Hingorjo, Sitwat Zehra, Zainab Hasan, Masood Anwar Qureshi
OBJECTIVE: This study investigated the relationship between cardiorespiratory fitness (CRF) and adiposity in young adults. METHODS: Data was collected from 133 students of a medical college of Pakistan. The study was conducted on young adults, aged 17-24 years, recruited from Jinnah Medical & Dental College, Karachi, between Aug-Dec, 2015. Queen's College Step Test was conducted to measure CRF and maximal oxygen uptake (VO2max) evaluated. Anthropometric measurements (body mass index, body fat, visceral fat, waist circumference) were taken to assess adiposity...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28805262/mesenchymal-stem-cells-attenuate-liver-fibrosis-by-suppressing-th17-cells
#2
Neda Milosavljevic, Marina Gazdic, Bojana Simovic Markovic, Aleksandar Arsenijevic, Jasmin Nurkovic, Zana Dolicanin, Nemanja Jovicic, Ilija Jeftic, Valentin Djonov, Nebojsa Arsenijevic, Miodrag L Lukic, Vladislav Volarevic
This study investigates molecular and cellular mechanisms involved in mesenchymal stem cell (MSCs)-mediated modulation of IL-17 signaling during liver fibrosis. Mice received CCl4 (1μL/g intraperitoneally) twice/week for 1 month. MSCs (1x10(6) ), or MSC-conditioned medium (MSC-CM) were intravenously injected 24h after CCl4 and on every 7(th) day. Liver fibrosis was determined by macroscopic examination, histological analysis, Sirius red staining and RT-PCR. Serum levels of cytokines, IDO and kynurenine were determined by ELISA...
August 14, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28801931/immunomodulatory-effects-of-adipose-stromal-vascular-fraction-cells-promote-alternative-activation-macrophages-to-repair-tissue-damage
#3
Annie C Bowles, Rachel M Wise, Brittany Y Gerstein, Robert C Thomas, Roberto Ogelman, Isabella Febbo, Bruce A Bunnell
The pathogenesis of many diseases is driven by the interactions between helper T (TH ) cells and macrophages. The phenotypes of these cells are a functional dichotomy that are persuaded according to the surrounding milieu. In both multiple sclerosis (MS) and the experimental autoimmune encephalomyelitis (EAE) model, TH 1 and TH 17 cells propagate autoimmune signaling and inflammation in the peripheral lymphoid tissues. In turn, this pro-inflammatory repertoire promotes the classical activation, formerly the M1-type, macrophages...
August 12, 2017: Stem Cells
https://www.readbyqxmd.com/read/28801784/prior-repeated-stress-attenuates-cold-induced-immunomodulation-associated-with-browning-in-mesenteric-fat-of-rats
#4
P Vargovic, M Laukova, J Ukropec, G Manz, R Kvetnansky
Continuous exposure to cold leads to activation of adaptive thermogenesis in brown adipose tissue but also to induction of brown/beige cell phenotype in white adipose tissue. The aim of this work was to investigate whether prior exposure to immobilization (IMO) stress may affect immune response associated with adipocyte "browning" in mesenteric adipose tissue (mWAT). In the first experiment, Sprague-Dawley rats were exposed to acute (3 h) or prolonged (7 days) cold exposure (4 ± 1 °C). 7-day cold stimulated gene expression of uncoupling protein 1 and other "browning"-associated factors...
August 11, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28797910/environmental-evaluation-of-natural-radioactivity-in-soil-near-a-lignite-burning-power-plant-in-turkey
#5
E Gören, Ş Turhan, A Kurnaz, A M K Garad, C Duran, F A Uğur, Z Yeğingil
Natural radionuclides are released into the environment together with fly ash from the coal-burning power plant and cause an increase in the natural radioactivity in environmental samples. The study concerns to the evaluation the influence of Kangal lignite-burning power plant (LBPP) with a power of 457 MWe, which has been in operation since 1989, on natural radionuclide a concentration in surface soil samples around it. Activity concentrations of natural radionuclides ((226)Ra, (232)Th, (40)K and (222)Rn) in the soil samples, and emanation coefficient (EC) and mass (ERM) and surface (ERS) exhalation rate of radon were determined by using a gamma-ray spectrometer with an HPGe detector...
August 1, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28795328/severe-hemorrhagic-shock-leads-to-a-delayed-fracture-healing-and-decreased-bone-callus-strength-in-a-mouse-model
#6
Katrin Bundkirchen, Christian Macke, Janin Reifenrath, Luisa Marilena Schäck, Sandra Noack, Borna Relja, Philipp Naber, Bastian Welke, Michael Fehr, Christian Krettek, Claudia Neunaber
BACKGROUND: Multiple trauma is frequently associated with hemorrhagic shock and fractures of the extremities. Clinically, the rate of impaired fracture healing (delayed healing and nonunion) seems to be increased in patients with multiple injuries compared with patients with isolated fractures. As the underlying pathogenesis remains poorly understood, we aimed to analyze the biomechanical properties during fracture healing in a murine model. QUESTIONS: The aim of this study was to determine whether fracture healing after severe hemorrhagic shock results in (1) delayed bridging as determined by macroscopic and radiographic assessment, (2) altered conditions of callus components as determined by µCT, and (3) decreased maximum bending moment measured by a three-point-bending test compared with ordinary fracture healing...
August 9, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28790231/inflammation-immunity-and-hypertension
#7
Arisya Agita, M Thaha Alsagaff
The immune system, inflammation and hypertension are related to each other. Innate and adaptive immunity system triggers an inflammatory process, in which blood pressure may increase, stimulating organ damage. Cells in innate immune system produce ROS, such as superoxide and hydrogen peroxide, which aimed at killing pathogens. Long-term inflammation process increases ROS production, causing oxidative stress which leads to endothelial dysfunction. Endothelial function is to regulate blood vessel tone and structure...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28781969/immunomodulatory-effects-of-taiwanese-neolitsea-species-on-th1-and-th2-functionality
#8
Yin-Hua Cheng, Ying-Chi Lin, Ih-Sheng Chen, Sian-De Liu, Jih-Heng Li, Chia-Chi Wang
Neolitsea species, medicinal plants belonging to Lauraceae, contain rich alkaloids, steroids, sesquiterpenoids, and triterpenoids which possess antimicrobial, antioxidant, and anti-inflammatory bioactivities. However, species differences in the immunomodulatory effects and evidence pertaining to the effects of Neolitsea species on adaptive immunity are scarce. This study aimed to evaluate the immunomodulatory properties of ten Taiwanese Neolitsea plants on T helper (Th) cell functionality, especially Th1 and Th2...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28776658/the-possessions-at-loudun-tracking-the-discourse-of-dissociation
#9
Craig E Stephenson
Embedded in the history of dissociation is the best known case of possession in European history, the 17(th) century possessions at Loudun, France (1632-1638). The exorcisms and the trial drew crowds from all over Europe, the outcome prefiguring the direction in which the Western science of mind would be carried. The published debate about the possessed and obsessed Ursuline nuns of Loudun spans four centuries. One can track how theorizing about dissociation changed over time, with psychological contributions by Jean Martin Charcot, Georges Gilles de la Tourette, Pierre Janet, Michel Foucault and Michel de Certeau...
September 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28772198/cerebral-regional-oxygen-saturation-trends-in-infants-with-hypoxic-ischemic-encephalopathy
#10
Siddharth V Jain, Lindsay Pagano, Maria Gillam-Krakauer, James C Slaughter, Sumit Pruthi, Barbara Engelhardt
BACKGROUND: Neurological outcomes in neonatal hypoxic-ischemic encephalopathy (HIE) continue to be sub-optimal despite therapeutic hypothermia (TH). Cerebral near-infrared spectroscopy provides real-time regional oxygen saturation (CrSO2) that may be a marker of adverse MRI findings and neurodevelopmental outcomes. AIM: The aim of this study was to examine the value of CrSO2 monitoring in infants with HIE undergoing TH. STUDY DESIGN AND SUBJECTS: In this prospective study, CrSO2 was continuously recorded in 21 infants with HIE admitted for TH...
July 31, 2017: Early Human Development
https://www.readbyqxmd.com/read/28762907/-subpopulation-composition-of-cd4-t-lymphocytes-as-factor-contributing-to-the-progression-of-atherosclerosis-of-carotid-arteries
#11
A Yu Filatova, E A Pylaeva, A V Potekhina, A K Osokina, O A Pogorelova, M I Tripoten, T V Balakhonova, S I Provatorov, E A Noeva, E A Klesareva, O I Afanasieva, T I Arefieva
AIM: to assess prognostic significance of blood content of regulatory and effector T-lymphocytes for progression of atherosclerosis (AS) of carotid arteries. MATERIAL AND METHODS: We enrolled in this study 33 men with various severity of carotid AS. Carotid artery duplex scan was done at admission and in 1 year after enrollment. AS progression was defined as appearance of novel stenosis in common or internal carotid artery or more or equal 5% increase of preexisting stenosis...
April 2017: Kardiologiia
https://www.readbyqxmd.com/read/28761200/a-prospective-study-of-altered-inflammatory-response-and-its-clinical-outcome-following-laparoscopic-and-open-cholecystectomy
#12
Sayyed Ehtesham Hussain Naqvi, Atia Zaka-Ur-Rab, Najmul Islam, Eram Ali
BACKGROUND: Inflammatory response following surgical trauma has long been a matter of study. Results, however, have been varied. We sought to assess changes in the levels of proinflammatory and anti-inflammatory cytokines in patients undergoing laparoscopic and open cholecystectomy and their impact on the clinical outcome of patients concerning the postoperative pain score. METHODS: The study involved 90 cholecystectomies (55 laparoscopic and 35 open) for chronic cholecystitis...
July 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28757754/therapeutic-hypothermia-brings-favorable-neurologic-outcomes-in-children-with-near-drowning
#13
Ming-Chun Chen, Chia-Hsiang Chu, Ching-Feng Cheng, Jun-Song Lin, Jui-Hsia Chen, Yu-Hsun Chang
A 1-year-10-month-old boy was admitted to our pediatric intensive care unit due to near drowning with pulmonary edema. A conventional ventilator with 100% oxygen supplementation was used initially, but was shifted to high frequency oscillatory ventilation as his oxygen saturation was around 84-88%. Therapeutic hypothermia was applied due to hypoxic ischemic encephalopathy with severe acidosis. His respiratory condition improved and he was extubated successfully on the 6(th) hospital day. The patient had no obvious neurological defects and he was discharged in a stable condition after 17 days of hospitalization...
October 2016: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28756805/burden-of-clostridium-difficile-infections-in-french-hospitals-in-2014-from-the-national-health-insurance-perspective
#14
Soline Leblanc, Cécile Blein, Antoine Andremont, Pierre-Alain Bandinelli, Thibaut Galvain
OBJECTIVE To describe the hospital stays of patients with Clostridium difficile infection (CDI) and to measure the hospitalization costs of CDI (as primary and secondary diagnoses) from the French national health insurance perspective DESIGN Burden of illness study SETTING All acute-care hospitals in France METHODS Data were extracted from the French national hospitalization database (PMSI) for patients covered by the national health insurance scheme in 2014. Hospitalizations were selected using the International Classification of Diseases, 10 th revision (ICD-10) code for CDI...
August 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28745029/adam10-and-notch1-on-murine-dendritic-cells-control-the-development-of-type-2-immunity-and-ige-production
#15
Sheela R Damle, Rebecca K Martin, Chelsea L Cockburn, Joseph C Lownik, Jason A Carlyon, Allen D Smith, Daniel H Conrad
BACKGROUND: Allergy and allergic asthma are significant health burdens in developed countries and are increasing in prevalence. Dendritic cells (DCs) initiate immune responses to common aeroallergens and ADAM10 has been demonstrated to be important for the development of adaptive responses. This study's objective was to understand the role of ADAM10 on DCs in the development of allergic and anaphylactic responses. METHODS: In this study we used mouse models of allergic airway inflammation (house dust mice and Alternaria alternata) and OVA-induced models of active anaphylaxis to determine the DC-specific function of ADAM10 and Notch signaling...
July 26, 2017: Allergy
https://www.readbyqxmd.com/read/28739765/relationship-of-th17-treg-cells-and-radiation-pneumonia-in-locally-advanced-esophageal-carcinoma
#16
Yan Wang, Gang Xu, Jie Wang, Xin-Hua Li, Ping Sun, Wei Zhang, Jun-Xia Li, Chao-Yang Wu
BACKGROUND/AIM: Radiation pneumonia is a main side-effect that has limited the clinical usage of radiotherapy in locally advanced esophageal carcinoma. T helper cells 17 (Th 17) and T regulatory cells (Tregs) play an important role in inflammatory diseases. The balance between Treg and Th17 cells is a key factor in the progression of many inflammatory and autoimmune diseases. Whether Tregs and Th17 cells are predictive factors of radiation pneumonia has not yet been reported. In this study, we investigated the relationships of Treg/Th17 cells and radiation pneumonia in patients with locally advanced esophageal cancer who received radiotherapy...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28738251/quantification-of-some-elements-of-nuclear-and-industrial-interest-from-zircon-mineral-using-neutron-activation-analysis-and-passive-gamma-ray-spectroscopy
#17
M F Attallah, M A Hilal, S I Moussa
A combined of various nuclear and analytical techniques were used for characterization of Egyptian zircon ore. Neutron activation analysis has been used for determination of the major, minor and trace elements from zircon ore. Non-destructive gamma-ray technique is also used for the radiometric analysis of zircon ore to quantify the natural radionuclides such as (238)U, (235)U, (232)Th, (226)Ra and (40)K. Zircon ore has been characterized by different analytical tools such as Fourier transformer infrared (FTIR), X-ray fluorescence (XRF), powder X-ray diffraction (XRD), and scanning electron microscopy (SEM)...
July 14, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28735510/fxa-inhibition-by-rivaroxaban-modifies-mechanisms-associated-with-the-pathogenesis-of-human-abdominal-aortic-aneurysms
#18
G Moñux, J J Zamorano-León, P Marqués, B Sopeña, J M García-García, G Laich de Koller, B Calvo-Rico, M A García-Fernandez, J Serrano, A López-Farré
AIM: To evaluate if Rivaroxaban, an oral factor Xa (FXa) inhibitor, could in vitro modify the expression of inflammatory and oxidative stress biomarkers in abdominal aortic aneurysmal (AAA) sites showing intraluminal thrombus. METHODS: AAA sites with intraluminal mural thrombus were obtained from six patients undergoing elective AAA repair. In addition, control abdominal aortic samples were obtained from six organ donors. AAA sites were incubated in the presence and absence of 50 nmol/L Rivaroxaban...
July 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28733643/recent-wetting-and-glacier-expansion-in-the-northwest-himalaya-and-karakoram
#19
Ram R Yadav, Anil K Gupta, Bahadur S Kotlia, Vikram Singh, Krishna G Misra, Akhilesh K Yadava, Anoop K Singh
Hydroclimatic variability driven by global warming in the climatically vulnerable cold semi-arid to arid northwest (NW) Himalaya is poorly constrained due to paucity of continuous weather records and annually resolved proxies. Applying a network of annually resolved tree-ring-width chronologies from semi-arid region of Kishtwar, Jammu and Kashmir, India, we reconstructed April-May standardized precipitation index extending back to A.D. 1439 (576 years). The reconstructed series is featured by the most conspicuous long-term droughts during the 15(th) to early 17(th) centuries followed by a general wetting, with 1984-2014 being the wettest interval in the past 576 years...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723587/evaluation-of-an-electronic-clinical-decision-support-tool-for-incident-elevated-bp-in-adolescents
#20
Elyse Olshen Kharbanda, Stephen E Asche, Alan Sinaiko, James D Nordin, Heidi L Ekstrom, Patricia Fontaine, Steven P Dehmer, Nancy E Sherwood, Patrick J O'Connor
OBJECTIVE: To evaluate, among adolescents 10-17 years with an incident hypertensive BP (≥95(th) percentile) at a primary care visit, whether TeenBP, a novel electronic health record (EHR) linked clinical decision support tool (CDS), improved recognition of elevated BP and return for follow-up BP evaluation. METHODS: We conducted a pragmatic cluster randomized trial in 20 primary care clinics in a large Midwestern medical group. Ten clinics received the TeenBP CDS, including an alert to remeasure a hypertensive BP at that visit, an alert that a hypertensive BP should be repeated in 1-3 weeks and patient-specific order sets...
July 16, 2017: Academic Pediatrics
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