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Interleukin 23

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https://www.readbyqxmd.com/read/29672858/neonates-colonized-with-pathogenic-bacteria-in-the-airways-have-a-low-grade-systemic-inflammation
#1
Nadia Rahman Fink, Bo Lund Chawes, Jonathan Thorsen, Jakob Stokholm, Karen Krogfelt, Susanne Schjørring, Marie Kragh, Klaus Bønnelykke, Susanne Brix, Hans Bisgaard
BACKGROUND AND OBJECTIVES: The development of childhood asthma is associated with neonatal colonization with pathogenic bacteria in hypopharynx. Furthermore, established asthma is associated with systemic low-grade inflammation. We here report on the association between neonatal colonization with pathogenic bacteria in hypopharynx and the development of systemic low-grade inflammation. METHODS: Bacterial colonization of the hypopharynx with M. catharralis, H. influenzae and/or S...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29672044/andrographolide-antagonizes-tnf-%C3%AE-induced-il-8-via-inhibition-of-nadph-oxidase-ros-nf-%C3%AE%C2%BAb-and-src-mapks-ap-1-axis-in-human-colorectal-cancer-hct116-cells
#2
Miaomiao Yuan, Wei Meng, Wenzhen Liao, Sen Lian
Andrographis paniculata Nees is used as a functional food in Japan, Korea, India and China. Andrographolide, a naturally occurring phytochemical identified in Andrographis paniculata, has been discovered to present anti-inflammatory and anticancer activities. Highly expressed of interleukin (IL-8) has been detected in colorectal cancer and is implicated in angiogenesis. However, the effect and molecular mechanisms of IL-8 expression by andrographolide remain obscure in human colorectal cancer cells. The present study was aimed to investigate the effects of andrographolide on TNF-α-induced IL-8 expression and its underlying mechanisms...
April 19, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29671344/subclinical-cardiovascular-disease-parameters-after-one-year-in-new-users-of-depot-medroxyprogesterone-acetate-compared-to-copper-iud
#3
Kleber Cursino, Gabriel Araújo de Lima, Priscilla de Nazaré Silva Dos Santos, Elizabeth João Pavin, Luis Bahamondes, Arlete Fernandes
PURPOSE: To evaluate markers of cardiovascular disease in women with normal insulin sensitivity who had recently initiated use of depot medroxyprogesterone acetate (DMPA) as a contraceptive. MATERIALS AND METHODS: A prospective, non-randomised, comparative study. Data of 30 women of 18-40 years of age, with normal hyperinsulinaemic-euglycaemic clamp at baseline and body mass index (BMI) < 30, who opted to use DMPA or a copper intrauterine device (IUD) as a contraceptive, were analysed...
April 19, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29670615/distinct-in-vitro-t-helper-17-differentiation-capacity-of-peripheral-naive-t-cells-in-rheumatoid-and-psoriatic-arthritis
#4
Eszter Baricza, Nikolett Marton, Panna Királyhidi, Orsolya Tünde Kovács, Ilona Kovácsné Székely, Eszter Lajkó, Lászó Kőhidai, Bernadett Rojkovich, Barbara Érsek, Edit Irén Buzás, György Nagy
Background: The T-helper 17 (Th17) cells have a prominent role in inflammation as well as in bone and join destruction in both rheumatoid and psoriatic arthritis (RA and PsA). Here, we studied Th17 cell differentiation in RA and PsA. Methods: Blood samples from healthy donors, RA and PsA patients were collected. CD45RO- (naive) and CD45RO+ (memory) T cells were isolated from peripherial blood mononuclear cell by magnetic separation. Naive T cells were stimulated with anti-CD3, anti-CD28, and goat anti-mouse IgG antibodies and treated with transforming grow factor beta, interleukin (IL)-6, IL-1β , and IL-23 cytokines and also with anti-IL-4 antibody...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670537/impact-of-different-tidal-volume-levels-at-low-mechanical-power-on-ventilator-induced-lung-injury-in-rats
#5
Lillian Moraes, Pedro L Silva, Alessandra Thompson, Cintia L Santos, Raquel S Santos, Marcos V S Fernandes, Marcelo M Morales, Vanessa Martins, Vera L Capelozzi, Marcelo G de Abreu, Paolo Pelosi, Patricia R M Rocco
Tidal volume (VT ) has been considered the main determinant of ventilator-induced lung injury (VILI). Recently, experimental studies have suggested that mechanical power transferred from the ventilator to the lungs is the promoter of VILI. We hypothesized that, as long as mechanical power is kept below a safe threshold, high VT should not be injurious. The present study aimed to investigate the impact of different VT levels and respiratory rates (RR) on lung function, diffuse alveolar damage (DAD), alveolar ultrastructure, and expression of genes related to inflammation [interleukin (IL)-6], alveolar stretch (amphiregulin), epithelial [club cell secretory protein (CC)16] and endothelial [intercellular adhesion molecule (ICAM)-1] cell injury, and extracellular matrix damage [syndecan-1, decorin, and metalloproteinase (MMP)-9] in experimental acute respiratory distress syndrome (ARDS) under low-power mechanical ventilation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29665498/glabridin-an-isoflavan-from-licorice-root-ameliorates-imiquimod-induced-psoriasis-like-inflammation-of-balb-c-mice
#6
Penghui Li, Yonglian Li, Hong Jiang, Yuting Xu, Xiaoying Liu, Biao Che, Jian Tang, Guangrong Liu, Yadong Tang, Wei Zhou, Langyue Zhang, Changzhi Dong, Huixiong Chen, Kun Zhang, Zhiyun Du
In this paper, we investigate the effect of glabridin (Glab) on psoriasis. We observed that Glab significantly suppressed the levels of nitric oxide (NO), NF-κB subunit p65, interleukin (IL)-6, and IL-1β in lipopolysaccharide (LPS)-stimulated HaCaT cells. In addition, Glab treatment reduced the expression of IL-17A, IL-22, and IL-23 in TNF-α-stimulated-HaCaT cells. These findings prompted us to test whether Glab could be used to treat psoriasis in vivo. The effects of Glab on PASI scores, histopathological changes, oxidative/anti-oxidative indexes and pro-inflammatory cytokines in IMQ-induced mice were investigated...
April 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29661675/burnt-sugarcane-harvesting-is-associated-with-rhinitis-symptoms-and-inflammatory-markers
#7
Iara Buriola Trevisan, Ubiratan de Paula Santos, Marceli Rocha Leite, Aline Duarte Ferreira, Bruna Spolador de Alencar Silva, Ana Paula Coelho Figueira Freire, Gabriel Faustino Santa Brigida, Ercy Mara Cipulo Ramos, Dionei Ramos
INTRODUCTION: Burnt sugarcane harvesting requires intense physical exertion in an environment with high temperatures and exposure to particulate matter. OBJECTIVE: To evaluate the effects of burnt sugarcane harvesting on rhinitis symptoms and inflammatory markers in sugarcane workers. METHODS: 32 male sugarcane workers were evaluated with questionnaire for rhinitis symptoms, and for inflammatory markers on peripheral blood and nasal lavage, in the non-harvesting, and 3 and 6 months into the sugarcane harvesting period...
April 5, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29659743/association-of-biomarker-and-physiologic-indices-with-mortality-in-older-adults-cardiovascular-health-study
#8
Jason L Sanders, Alice M Arnold, Robert M Boudreau, Calvin H Hirsch, Jorge R Kizer, Robert C Kaplan, Anne R Cappola, Mary Cushman, Mini E Jacob, Stephen B Kritchevsky, Anne B Newman
Background: A goal of gerontology is discovering aging phenotypes that reflect biological aging distinct from disease pathogenesis. Biomarkers strongly and independently associated with mortality and which statistically attenuate chronologic age could be used to define such a phenotype. We determined the association of a Biomarker Index (BI) with mortality and compared it to a validated Physiologic Index (PI) in older adults. Methods: The indices were constructed in the Cardiovascular Health Study, mean (SD) age 74...
April 12, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29659729/t-helper-17-1-cells-associate-with-multiple-sclerosis-disease-activity-perspectives-for-early-intervention
#9
Jamie van Langelaar, Roos M van der Vuurst de Vries, Malou Janssen, Annet F Wierenga-Wolf, Isis M Spilt, Theodora A Siepman, Wendy Dankers, Georges M G M Verjans, Helga E de Vries, Erik Lubberts, Rogier Q Hintzen, Marvin M van Luijn
Interleukin-17-expressing CD4+ T helper 17 (Th17) cells are considered as critical regulators of multiple sclerosis disease activity. However, depending on the species and pro-inflammatory milieu, Th17 cells are functionally heterogeneous, consisting of subpopulations that differentially produce interleukin-17, interferon-gamma and granulocyte macrophage colony-stimulating factor. In the current study, we studied distinct effector phenotypes of human Th17 cells and their correlation with disease activity in multiple sclerosis patients...
April 5, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29656959/genetic-variants-in-il-33-st2-pathway-with-the-susceptibility-to-hepatocellular-carcinoma-in-a-chinese-population
#10
Zhong-Heng Wei, Yue-Yong Li, Shi-Qing Huang, Zhong-Qiu Tan
Interleukin (IL)-33/ST2 pathway plays a pivotal role in tumorigenesis through influencing cancer stemness, tumor growth, metastasis, angiogenesis, and accumulation of regulatory T cells in tumor microenvironments. The aim of this study was to investigate the association of IL-33 rs7025417 and ST2 rs3821204 with the risk of hepatocellular carcinoma (HCC). Genotyping of IL-33 rs7025417 and ST2 rs3821204 was carried out using a Taqman assay. IL-33 and ST2 mRNA was examined using real-time PCR and plasma IL-33 and sST2 levels were measured using enzyme-linked immunosorbent assay...
April 12, 2018: Cytokine
https://www.readbyqxmd.com/read/29643997/new-antimicrobial-peptide-kills-drug-resistant-pathogens-without-detectable-resistance
#11
Jong-Kook Lee, Tudor Luchian, Yoonkyung Park
Clavaspirin peptide (CSP) is derived from the pharyngeal tissues of the tunicate Styela clava . The 23-amino acid peptide is histidine-rich and amidated at the N-terminus. CSP possesses low antimicrobial and high hemolytic activity at pH 7.4. Therefore, we designed 4 CSP analogs with substituted hydrophobic amino acids to reduce hydrophobic amino acid interactions. These modifications reduced the aggregation and cytotoxicity of the analogs at pH 7.4. The analogs also showed potent antimicrobial activity by accumulating on bacterial cell surfaces and inducing the lytic mechanism against gram-negative and gram-positive cells at pH 5...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29628312/alt-803-an-il-15-superagonist-in-combination-with-nivolumab-in-patients-with-metastatic-non-small-cell-lung-cancer-a-non-randomised-open-label-phase-1b-trial
#12
John M Wrangle, Vamsidhar Velcheti, Manish R Patel, Elizabeth Garrett-Mayer, Elizabeth G Hill, James G Ravenel, Jeffrey S Miller, Mohammad Farhad, Kate Anderton, Kathryn Lindsey, Michele Taffaro-Neskey, Carol Sherman, Samantha Suriano, Marzena Swiderska-Syn, Amy Sion, Joni Harris, Andie R Edwards, Julie A Rytlewski, Catherine M Sanders, Erik C Yusko, Mark D Robinson, Carsten Krieg, William L Redmond, Jack O Egan, Peter R Rhode, Emily K Jeng, Amy D Rock, Hing C Wong, Mark P Rubinstein
BACKGROUND: Immunotherapy with PD-1 or PD-L1 blockade fails to induce a response in about 80% of patients with unselected non-small cell lung cancer (NSCLC), and many of those who do initially respond then develop resistance to treatment. Agonists that target the shared interleukin-2 (IL-2) and IL-15Rβγ pathway have induced complete and durable responses in some cancers, but no studies have been done to assess the safety or efficacy of these agonists in combination with anti-PD-1 immunotherapy...
April 5, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29624921/a-genetic-variant-in-il-15r%C3%AE-correlates-with-physical-activity-among-european-american-adults
#13
Michael Bruneau, Sean Walsh, Eric Selinsky, Garrett Ash, Theodore J Angelopoulos, Priscilla Clarkson, Paul Gordon, Niall Moyna, Paul Visich, Robert Zoeller, Paul Thompson, Heather Gordish-Dressman, Eric Hoffman, Joseph Devaney, Linda S Pescatello
BACKGROUND: Interleukin-15 (IL-15) is a myokine associated with muscle strength, possibly by attenuating protein breakdown. A variant in the alpha-receptor (IL-15Rα 1775 A>C, rs2228059) partially modulates the muscle strength and size response to resistance training. We examined if this polymorphism associated with habitual physical activity among European-American adults. METHODS: Men (n = 240, 23.7 ± 0.3 year, body mass index [BMI] 25.3 ± 0.3 kg/m2 ) and women (n = 292, 23...
April 6, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29623491/the-complex-alteration-in-the-network-of-il-17-type-cytokines-in-patients-with-hereditary-angioedema
#14
Francesco Arcoleo, Mariangela Lo Pizzo, Gabriella Misiano, Salvatore Milano, Giuseppina Colonna Romano, Vito Muggeo, Enrico Cillari
Hereditary angioedema (HAE) is a rare autosomic-dominant disorder characterized by a deficiency of C1 esterase inhibitor which causes episodic swellings of subcutaneous tissues, bowel walls and upper airways that are disabling and potentially life-threatening. We evaluated n = 17 patients with confirmed HAE diagnosis during attack and remission state and n = 19 healthy subjects. The samples were tested for a panel of IL (Interleukin)-17-type cytokines (IL-1β, IL-6, IL-10, granulocyte-macrophage colony stimulating factor (GM-CSF), IL-17, IL-21, IL-22, IL-23) and transforming growth factor-beta (TGF-β) subtypes...
April 6, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29622022/il-6-blockade-in-systemic-juvenile-idiopathic-arthritis-achievement-of-inactive-disease-and-remission-data-from-the-german-aid-registry
#15
M Bielak, E Husmann, N Weyandt, J-P Haas, B Hügle, G Horneff, U Neudorf, T Lutz, E Lilienthal, T Kallinich, K Tenbrock, R Berendes, T Niehues, H Wittkowski, E Weißbarth-Riedel, G Heubner, P Oommen, J Klotsche, Dirk Foell, E Lainka
BACKGROUND: Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with an autoinflammatory component of unknown etiology related to the innate immune system. A major role in the pathogenesis has been ascribed to proinflammatory cytokines like interleukin-6 (IL-6), and effective drugs inhibiting their signaling are being developed. This study evaluates sJIA patients treated with the IL-6 inhibitor tocilizumab (TCZ) concerning clinical response rate, disease course and adverse effects in a real-life clinical setting...
April 5, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29621530/molecular-cloning-and-expression-study-on-toll-like-receptor-5m-in-turbot-scophthalmus-maximus
#16
Dahai Liu, Jingjing Chen, Song Li, Guobin Hu
Toll-like receptor 5 (TLR5) is responsible for the recognition of bacterial flagellin in mammals and play an important role in innate immunity. In the present study, a TLR5M gene was cloned from turbot, Scophthalmus maximus, and its immune responsive expression was subsequently studied in vivo. The Scophthalmus maximus (Sm)TLR5M gene is 4268 bp in length, consists of four exons and three introns and encodes a peptide of 892 amino acids (aa). The deduced protein possesses a signal peptide sequence, a leucine-rich repeat (LRR) domain composed of 23 LRR motifs, a transmembrane (TM) domain and a Toll/interleukin-1 receptor (TIR) domain...
April 2, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29619030/dopaminergic-stimulation-of-myeloid-antigen-presenting-cells-attenuates-signal-transducer-and-activator-of-transcription-3-activation-favouring-the-development-of-experimental-autoimmune-encephalomyelitis
#17
Carolina Prado, Michela Gaiazzi, Hugo González, Valentina Ugalde, Alicia Figueroa, Francisco J Osorio-Barrios, Ernesto López, Alvaro Lladser, Emanuela Rasini, Franca Marino, Mauro Zaffaroni, Marco Cosentino, Rodrigo Pacheco
The dual potential to promote tolerance or inflammation to self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. Previous results have shown that stimulation of dopamine receptor D5 (DRD5) in DCs potentiates their inflammatory behaviour, favouring the development of experimental autoimmune encephalomyelitis (EAE). Here, we aimed to decipher the underlying mechanism and to test its relevance in multiple sclerosis (MS) patients. Our data shows that DRD5-deficiency confined to DCs in EAE mice resulted in reduced frequencies of CD4+ T-cell subsets with inflammatory potential in the central nervous system, including not only Th1 and Th17 cells but also granulocyte-macrophage colony-stimulating factor producers...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29618473/il-23r-deficiency-does-not-impact-atherosclerotic-plaque-development-in-mice
#18
Daniel Engelbertsen, Marie A C Depuydt, Robin A F Verwilligen, Sara Rattik, Erik Levinsohn, Andreas Edsfeldt, Felicia Kuperwaser, Petr Jarolim, Andrew H Lichtman
BACKGROUND: Interleukin-23 (IL-23) has been implicated in inflammatory and autoimmune diseases by skewing CD4+ T helper cells towards a pathogenic Th17 phenotype. In this study we investigated the presence of IL-23 receptor (IL-23R)-expressing cells in the atherosclerotic aorta and evaluated the effect of IL-23R deficiency on atherosclerosis development in mice. METHODS AND RESULTS: We used heterozygous Ldlr -/- Il23r e GFP / WT knock-in mice to identify IL-23R-expressing cells by flow cytometry and homozygous Ldlr -/- Il23r e GFP / eGFP ( Ldlr -/- Il23r -/- ) mice to investigate the effect of lack of IL-23R in atherosclerosis...
April 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29618277/spinal-fluid-cytokine-levels-and-single-photon-emission-computed-tomography-findings-in-complex-febrile-seizures
#19
Gaku Yamanaka, Yu Ishida, Shinichiro Morichi, Natsumi Morishita, Mika Takeshita, Urabe Tomomi, Mori Tomoko, Shingo Oana, Yasuyo Kashiwagi
In this study, the authors assessed cerebrospinal fluid cytokine levels and single-photon emission computed tomography (SPECT) findings in complex febrile seizures. This study included 23 Japanese patients with complex febrile seizures. Twenty patients underwent SPECT and 12 underwent analysis of cerebrospinal fluid cytokine levels (interleukin [IL]-6, interleukin-10, interleukin-17, interleukin-1β, tumor necrosis factor-α, and interferon-γ); 9 patients underwent both studies. Cerebrospinal fluid cytokine levels were compared between the current complex febrile seizure patients and 30 patients with acute encephalopathy...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29617527/association-of-hidradenitis-suppurativa-with-t-helper-1-t-helper-17-phenotypes-a-semantic-map-analysis
#20
Rahel Thomi, Simone Cazzaniga, S Morteza Seyed Jafari, Christoph Schlapbach, Robert E Hunger
Importance: In spite of progress in understanding the mechanisms underlying hidradenitis suppurativa (HS) as an inflammatory skin disease, there is still a demand for an overview on immunopathogenesis of HS. Objective: To demonstrate the importance of the type 1/type 17 immune response in lesional HS skin by drawing a semantic connectivity map. Design, Setting, and Participants: Single-center case series of 24 patients with HS. Association of HS with T helper 1/T helper 17 (TH1/TH17) phenotype was assessed using semantic map analysis...
April 4, 2018: JAMA Dermatology
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