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Interleukin 22

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https://www.readbyqxmd.com/read/28076559/anti-inflammatory-effect-of-lycopene-on-endotoxin-induced-uveitis-in-rats
#1
Tuğba Göncü, Elif Oğuz, Hatice Sezen, Sezen Koçarslan, Halit Oğuz, Ali Akal, Fatih Mehmet Adıbelli, Sevim Çakmak, Nurten Aksoy
Purpose: We evaluated the efficacy of lycopene, a dietary carotenoid and potent antioxidant, against ocular inflammation and oxidative stress in an experimental uveitis model. Methods: Endotoxin-induced uveitis (EIU) was induced in Sprague-Dawley rats by a single subcutaneous injection of 200 μg lipopolysaccharide (LPS). Induction of EIU was preceded by daily intraperitoneal injection of 10 mg/kg lycopene for three consecutive days (Lycopene + LPS group) or equivolume vehicle (Vehicle + LPS group)...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28073178/polyclonal-and-monoclonal-antibodies-for-induction-therapy-in-kidney-transplant-recipients
#2
REVIEW
Penny Hill, Nicholas B Cross, A Nicholas R Barnett, Suetonia C Palmer, Angela C Webster
BACKGROUND: Prolonging kidney transplant survival is an important clinical priority. Induction immunosuppression with antibody therapy is recommended at transplantation and non-depleting interleukin-2 receptor monoclonal antibodies (IL2Ra) are considered first line. It is suggested that recipients at high risk of rejection should receive lymphocyte-depleting antibodies but the relative benefits and harms of the available agents are uncertain. OBJECTIVES: We aimed to: evaluate the relative and absolute effects of different antibody preparations (except IL2Ra) when used as induction therapy in kidney transplant recipients; determine how the benefits and adverse events vary for each antibody preparation; determine how the benefits and harms vary for different formulations of antibody preparation; and determine whether the benefits and harms vary in specific subgroups of recipients (e...
January 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28069865/interleukin-22-restored-mitochondrial-damage-and-impaired-glucose-stimulated-insulin-secretion-through-down-regulation-of-uncoupling-protein-2-in-ins-1-cells
#3
Minling Hu, Hanxiao Lin, Li Yang, Yanzhen Cheng, Hua Zhang
Defective glucose-stimulated insulin secretion (GSIS) induced by chronic exposure to fatty acids is a hallmark of type 2 diabetes (T2D). Interleukin-22 (IL-22) has been shown to exert beneficial effects on insulin secretion and to protect pancreatic β-cells from stress. Moreover, uncoupling protein-2 (UCP-2) plays a central role in the regulation of GSIS and β-cell dysfunction, whereas the role of UCP-2 in IL-22-enhanced glycemic control under conditions of lipotoxicity remains unclear. In this present study, we investigated the effects of IL-22 on rat insulin-secreting cells (INS-1 cells) and the mechanisms that underlie IL-22 and lipotoxicity-impaired GSIS in vitro...
January 7, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28064069/immunization-with-leishmania-donovani-protein-disulfide-isomerase-dna-construct-induces-th1-and-th17-dependent-immune-response-and-protection-against-experimental-visceral-leishmaniasis-in-balb-c-mice
#4
Ajay Amit, Vijayamahantesh, Manas R Dikhit, Ashish Kumar Singh, Vikash Kumar, Shashi S Suman, Ashu Singh, Akhilesh Kumar, Ajit Kumar Thakur, Vidyanand Ravi Das, Pradeep Das, Sanjiva Bimal
In the present study, the efficacy of Leishmania donovani protein disulfide isomerase (LdPDI) as a DNA vaccine was evaluated in BALB/C mice. Mice immunized with the LdPDI-DNA construct were found to be the most immuno-reactive, as the construct induced higher T-cell proliferation. The increased T-cell proliferation was associated with a substantial rise in Th1 and Th17+ CD4 cell response and triggered a higher proportion of CD8+ T cells for the release of interferon-gamma along with a reduced splenic parasite load on Days20 and 60 post challenge (PC)...
January 5, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28061004/objective-physical-and-mental-markers-of-self-reported-fatigue-in-women-undergoing-neo-adjuvant-chemotherapy-for-early-stage-breast-cancer
#5
Joanne E Mortimer, Sarah Waliany, Christina M Dieli-Conwright, Sunita K Patel, Arti Hurria, Joseph Chao, Brian Tiep, Carolyn E Behrendt
BACKGROUND: Objective, treatment-independent markers of cancer-related fatigue are needed to advance clinical trials. In the current study, the authors evaluated physical, neurocognitive, and serologic markers for correlation with self-reported fatigue before and after (neo)adjuvant chemotherapy for patients with early-stage breast cancer. METHODS: Women with AJCC TNM Stage I-III breast cancer consented to assessment before and after the completion of 4 cycles of dose-dense doxorubicin and cyclophosphamide...
January 6, 2017: Cancer
https://www.readbyqxmd.com/read/28051088/lacrimal-gland-derived-il-22-regulates-il-17-mediated-ocular-mucosal-inflammation
#6
Y W Ji, S K Mittal, H S Hwang, E-J Chang, J H Lee, Y Seo, A Yeo, H Noh, H S Lee, S K Chauhan, H K Lee
Inflammatory damage of mucosal surface of the eye is a hallmark of dry eye disease (DED) and, in severe cases, can lead to significant discomfort, visual impairment, and blindness. DED is a multifactorial autoimmune disorder with a largely unknown pathogenesis. Using a cross-sectional patient study and a well-characterized murine model of DED, herein we investigated the immunoregulatory function of interleukin-22 (IL-22) in the pathogenesis of DED. We found that IL-22 levels were elevated in lacrimal fluids of DED patients and inversely correlated with severity of disease...
January 4, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28043722/metabolic-and-inflammatory-responses-and-subsequent-recovery-in-robotic-versus-abdominal-hysterectomy-a-randomised-controlled-study
#7
Lena Wijk, Kerstin Nilsson, Olle Ljungqvist
BACKGROUND & AIMS: Surgery causes inflammatory and metabolic responses in the body. The aim of the study was to investigate whether robotic-assisted total laparoscopic hysterectomy induces less insulin resistance than abdominal hysterectomy, and to compare inflammatory response and clinical recovery between the two techniques. METHODS: A randomised controlled study at the Department of Obstetrics and Gynaecology, Örebro University Hospital, Sweden. Twenty women scheduled for a planned total hysterectomy with or without salpingo-oophorectomy between October 2014 and May 2015, were randomly allocated to robotic-assisted total laparoscopic hysterectomy or abdominal hysterectomy...
December 23, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28040120/a-mixture-of-st-john-s-wort-and-sea-buckthorn-oils-regresses-endometriotic-implants-and-affects-the-levels-of-inflammatory-mediators-in-peritoneal-fluid-of-the-rat-a-surgically-induced-endometriosis-model
#8
Mert İlhan, İpek Süntar, Mürşide Ayşe Demirel, Erdem Yeşilada, Hikmet Keleş, Esra Küpeli Akkol
OBJECTIVE: Sea buckthorn (Hippophae rhamnoides L.) and St. John's wort (Hypericum perforatum L.) are used as an emmenagog and for the treatment of other gynecological disorders including uterus inflammation and endometriosis. The aim of the present study is to investigate the potential of a mixture of sea buckthorn and St. John's wort oils (HrHp oil) in the treatment of endometriosis. MATERIALS AND METHODS: The activity was assessed in surgically induced endometriosis in rats...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28039586/plasma-phospholipid-fatty-acid-profile-is-altered-in-both-septic-and-non-septic-critically-ill-a-correlation-with-inflammatory-markers-and-albumin
#9
František Novak, J Borovska, M Vecka, J Rychlikova, L Vavrova, H Petraskova, A Zak, O Novakova
This study analyzes fatty acid (FA) composition in plasma lipids and erythrocyte phospholipids while comparing septic and non-septic critically ill patients. The aim was to describe impacts of infection and the inflammatory process. Patients with severe sepsis (SP, n = 13); age-, sex- and APACHE II score-matched non-septic critically ill with systemic inflammatory response syndrome (NSP, n = 13); and age-/sex-matched healthy controls (HC, n = 13) were included in a prospective case-control study during the first 24 h after admission to the intensive care unit...
December 30, 2016: Lipids
https://www.readbyqxmd.com/read/28038358/il-22-promotes-fas-expression-in-oligodendrocytes-and-inhibits-foxp3-expression-in-t-cells-by-activating-the-nf-%C3%AE%C2%BAb-pathway-in-multiple-sclerosis
#10
Jin Zhen, Jun Yuan, Yongwang Fu, Runxiu Zhu, Meiling Wang, Hong Chang, Yan Zhao, Dong Wang, Zuneng Lu
Multiple sclerosis (MS) is characterized by an increase in interleukin-22 and Fas, and a decrease in FOXP3, among other factors. In this study, we examined patients with MS and healthy control subjects and used the experimental autoimmune encephalomyelitis (EAE) animal model to identify the effects of IL-22 on oligodendrocytes and T cells in MS development. In MS, the expression of Fas in oligodendrocytes and IL-22 in CD4(+)CCR4(+)CCR6(+)CCR10(+) T cells was enhanced. Ikaros and FOXP3 were both decreased in T cells...
December 27, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/28030850/changes-of-circulating-th22-cells-in-children-with-hand-foot-and-mouth-disease-caused-by-enterovirus-71-infection
#11
Dawei Cui, Fengyun Zhong, Jie Lin, Yidong Wu, Quan Long, Xianzhi Yang, Qiaoyun Zhu, Li Huang, Qifen Mao, Zhaoxia Huo, Zhe Zhou, Guoliang Xie, Shufa Zheng, Fei Yu, Yu Chen
Interleukin (IL)-22+CD4+T (Th22) cells play crucial roles in the pathogenesis of autoimmune diseases and infectious diseases, although the role of Th22 cells remains largely unclear in children with hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71). This study aims to explore the role of circulating IL-22+IL-17A-CD4+T (cTh22) cells in children with EV71-associated HFMD. We found that during the acute stage of illness, the frequencies of cTh22 and circulating IL-22+IL-17A+CD4+T (IL-22+cTh17) cells in CD4+T cells infrom affected patients, and especially in severely affected patients, were significantly higher than in healthy controls (HC)...
December 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/28029485/shenfu-injection-for-improving-cellular-immunity-and-clinical-outcome-in-patients-with-sepsis-or-septic-shock
#12
Ning Zhang, Jianhua Liu, Zeliang Qiu, Yiping Ye, Jian Zhang, Tianzheng Lou
PURPOSE: To assess the efficacy of Shenfu injection (SFI) for enhancing cellular immunity and improving the clinical outcomes of patients with septic shock. METHODS: Patients with sepsis were randomly assigned to receive either SFI at a dose of 100mL every 24hours for 7 consecutive days or a placebo in addition to conventional therapy. The immunologic parameters were collected on days 1, 3, and 7 after the above treatments, and the clinical outcomes were updated for 28days...
September 7, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28028949/clarithromycin-decreases-il-6-concentration-in-serum-and-bal-fluid-in-patients-with-cryptogenic-organizing-pneumonia
#13
Elżbieta Radzikowska, Adriana Roży, Paulina Jagus, Małgorzata Polubiec-Kownacka, Elżbieta Wiatr, Joanna Chorostowska-Wynimko, Kazimierz Roszkowski-Śliż
BACKGROUND: Inflammatory cytokines are involved in the development of cryptogenic organizing pneumonia (COP). It has been shown that macrolides inhibit cytokine production in the alveolar macrophages of COP patients. OBJECTIVES: The aim of the study was to assess the concentrations of interleukin 1β (IL-1β), IL-6, IL-8 and transforming growth factor β (TGF-β) in serum and in bronchoalveolar lavage fluid (BAL-f) in COP patients treated with clarithromycin (CAM)...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28028723/shenfu-injection-inhibits-inflammation-in-patients-with-acute-myocardial-infarction-complicated-by-cardiac-shock
#14
Yan-Yan Jin, Hai Gao, Xin-Yong Zhang, Hui Ai, Xiao-Lin Zhu, Jing Wang
OBJECTIVES: To investigate the effect of Shenfu Injection (, SFI) on inflammatory factors in patients with acute myocardial infarction complicated by cardiogenic shock (CS) treated with and intra-aortic balloon pump (IABP). METHODS: This study enrolled 60 patients with ST-segment elevation myocardial infarction (STEMI) complicated by CS. Patients underwent IABP and emergency percutaneous coronary intervention (PCI) were randomly divided into two groups by random number table with 30 cases in each group, one given SFI treatment (100 mL/24 h), one not...
December 27, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28027282/role-of-rifampin-in-reducing-inflammation-and-neuronal-damage-in-childhood-bacterial-meningitis-a-pilot-randomized-controlled-trial
#15
Lipi Uppal, Sunit Singhi, Pratibha Singhi, Ritu Aggarwal
BACKGROUND: Treatment of acute bacterial meningitis in children with bactericidal antibiotics causes cell wall lysis and a surge in inflammatory cascade, which in turn contributes to neuronal damage and morbidity. Pretreament with a non-bacteriolytic antibiotic, such as rifampin, has been shown to attenuate the inflammatory response in experimental models of bacterial meningitis. In a pilot study in children with bacterial meningitis we have studied markers of inflammatory response and neuronal damage in two groups of children with bacterial meningitis, one group received rifampin pretreatment with ceftriaxone, other group received ceftriaxone alone...
December 23, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28024757/expression-of-inflammatory-cytokines-and-chemokines-in-replanted-permanent-teeth-with-external-root-resorption
#16
Juliana Vilela Bastos, Tarcilia A Silva, Enrico A Colosimo, Maria Ilma S Côrtes, Daniela Augusta B Ferreira, Eugenio Marcos A Goulart, Ricardo S Gomez, Walderez O Dutra
INTRODUCTION: The progressive forms of inflammatory external root resorption (IERR) and replacement external root resorption (RERR) are serious complications and the main causes of tooth loss after replantation. This study aimed to investigate the expression pattern of inflammatory molecules in extracted human teeth presenting with external root resorption (ERR) after replantation. METHODS: Root fragments from 22 teeth showing IERR and 20 teeth with RERR were triturated using a homogenizer to extract inflammatory molecules...
December 23, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/28011187/mucosal-associated-invariant-t-cells-are-depleted-and-functionally-altered-in-patients-with-common-variable-immunodeficiency
#17
Serena Arduini, Jean Dunne, Niall Conlon, Conleth Feighery, Derek G Doherty
Common variable immunodeficiency (CVID) is a primary immunoglobulin deficiency characterized by recurrent infections and complications, including autoimmunity, enteropathy, polyclonal lymphocytic infiltration or lymphoid malignancy. Innate T cells can support B cell maturation and antibody production. We investigated the numbers, phenotypes and functions of circulating B cell, γδ T cell, invariant natural killer T (iNKT) cell and mucosal-associated invariant T (MAIT) cell subsets in 23 CVID patients and 27 healthy controls...
December 20, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28009536/leucine-protects-against-skeletal-muscle-atrophy-in-lipopolysaccharide-challenged-rats
#18
Jin Wan, Daiwen Chen, Bing Yu, Yuheng Luo, Xiangbing Mao, Ping Zheng, Jie Yu, Junqiu Luo, Jun He
Skeletal muscle atrophy is a decrease in muscle mass that occurs when protein degradation exceeds protein synthesis. Leucine (Leu), an essential branched-chain amino acid in animal nutrition, regulates skeletal muscle protein metabolism. Two experiments were conducted to evaluate whether Leu could alleviate lipopolysaccharide (LPS)-induced skeletal muscle wasting by modulating skeletal muscle protein synthesis and degradation. A total of 24 rats were randomly allocated into three groups (n = 8): (1) non-challenged control; (2) LPS-challenged control; and (3) LPS +3...
December 23, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28008750/the-additional-effects-of-a-probiotic-mix-on-abdominal-adiposity-and-antioxidant-status-a-double-blind-randomized-trial
#19
Aline Corado Gomes, Rávila Graziany Machado de Sousa, Patrícia Borges Botelho, Tatyanne Letícia Nogueira Gomes, Patrícia Oliveira Prada, João Felipe Mota
OBJECTIVE: To investigate whether a probiotic mix has additional effects when compared with an isolated dietary intervention on the body composition, lipid profile, endotoxemia, inflammation, and antioxidant profile. METHODS: Women who had excess weight or obesity were recruited to a randomized, double-blind trial and received a probiotic mix (Lactobacillus acidophilus and casei; Lactococcus lactis; Bifidobacterium bifidum and lactis; 2 × 10(10) colony-forming units/day) (n = 21) or placebo (n = 22) for 8 weeks...
January 2017: Obesity
https://www.readbyqxmd.com/read/28004013/aberrant-expression-of-interleukin-6-and-its-receptor-in-fallopian-tubes-bearing-an-ectopic-pregnancy-with-and-without-tubal-cytomegalovirus-infection
#20
Ahmed Mohamed Ashshi
Cytomegalovirus (CMV) has recently been suggested as a potential risk factor for the development of ectopic pregnancy (EP) following upper genital tract infection in women. However, little is known about its associated underlying pathogenic mechanisms. This was a prospective case-control study that measured the prevalence of CMV infection in Fallopian tubes (FT) bearing an EP and its effects on the tubal expression of interleukin (IL)-6 and its signaling molecules, which are known to play significant roles in the immune response against CMV infection as well as embryo implantation...
December 2016: Virusdisease
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