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Muc5ac

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https://www.readbyqxmd.com/read/27884794/peroxiredoxin-6-suppresses-muc5ac-overproduction-in-lps-induced-airway-inflammation-through-h2o2-egfr-mapk-signaling-pathway
#1
Dong Yang, Meiling Jin, Chunxue Bai, Jian Zhou, Yao Shen
Mucus hypersecretion is a prominent mechanism in airway inflammation. Muc5ac is a major component of mucus and can be activated by reactive oxygen species (ROS). Peroxiredoxin 6 (Prdx6) highly expresses in airway epithelium and protects the airway from oxidative stress. In this study, we investigated the roles of Prdx6 in lipopolysaccharide (LPS)-induced mucin production in mice. We found that the levels of H2O2 and the Muc5ac mRNA were significantly increased in Prdx6 (-/-) mice compared to those in C57BL/6J mice after LPS instillation, which were markedly inhibited by epithelial growth factor receptor (EGFR) inhibitor Elrotinib...
November 21, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27878831/i%C3%AE%C2%BAbns-induces-muc5ac-expression-in-epithelial-cells-and-causes-airway-hyper-responsiveness-in-murine-asthma-models
#2
M Yokota, T Tamachi, Y Yokoyama, Y Maezawa, H Takatori, A Suto, K Suzuki, K Hirose, K Takeda, H Nakajima
BACKGROUND: In allergic asthma, environmental allergens including house dust mite (HDM) trigger pattern recognition receptors and activate downstream signaling pathways including NF-κB pathways not only in immune cells but also in airway epithelial cells. Recent studies have shown that NF-κB activation is regulated positively or negatively depending on the cellular context by IκBNS (encoded by the gene Nfkbid), one of atypical IκB proteins, in the nucleus. Therefore, we hypothesized that IκBNS expressed in immune cells or epithelial cells is involved in the regulation of asthmatic responses...
November 6, 2016: Allergy
https://www.readbyqxmd.com/read/27870702/synchronous-ovarian-and-appendiceal-mucinous-neoplasms-in-the-absence-of-pseudomyxoma-peritonei
#3
Xianyong Gui, Jorge Escobar, Cheng-Han Lee, Máire A Duggan, Martin Köbel
BACKGROUND: Synchronous ovarian/appendiceal mucinous neoplasms sometimes occur in the absence of clinical pseudomyxoma peritonei (PMP), which raises a question about whether the 2 tumors could be independent. METHODS: We identified 11 cases of synchronous ovarian/appendiceal mucinous neoplasms without PMP and subclassified them into groups 1 and 2 based on the presence or absence of microscopic peritoneal/ovarian surface mucin deposits. A 7-marker panel (CK7, CK20, CDX2, PAX8, MUC1, MUC2, and MUC5AC) immunohistochemistry was performed on both tumors...
November 17, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27866297/nps2143-inhibits-muc5ac-and-proinflammatory-mediators-in-cigarette-smoke-extract-cse-stimulated-human-airway-epithelial-cells
#4
Jae-Won Lee, Ji-Won Park, Ok-Kyoung Kwon, Hee Jae Lee, Hye Gwang Jeong, Jae-Hong Kim, Sei-Ryang Oh, Kyoung-Seop Ahn
Mucus overproduction is a fundamental hallmark of COPD that is caused by exposure to cigarette smoke. MUC5AC is one of the main mucin genes expressed in the respiratory epithelium, and its transcriptional upregulation often correlates with increased mucus secretion. Calcium-sensing receptor (CaSR) antagonists have been reported to possess anti-inflammatory effects. The purpose of the present study was to investigate the protective role of NPS2143, a selective CaSR antagonist on cigarette smoke extract (CSE)-stimulated NCI-H292 mucoepidermoid human lung cells...
November 19, 2016: Inflammation
https://www.readbyqxmd.com/read/27859731/one-pot-ligation-oxidative-deselenization-at-selenocysteine-and-selenocystine
#5
Richard James Payne, Nicholas Mitchell, Sameer Kulkarni, Siyao Wang, Lara Malins
The use of native chemical ligation at selenocysteine (Sec) with peptide thioesters and additive-free selenocystine ligation with peptides bearing phenyl selenoesters, in concert with one-pot oxidative deselenization chemistry, is described. These approaches provide a simple and rapid method for accessing native peptides with serine in place of Sec at the ligation junction. The efficiency of both variants of the one-pot ligation-oxidative deselenization chemistry is probed through the synthesis of a MUC5AC-derived glycopeptide...
November 16, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27846863/prognostic-significance-of-mucin-expression-profiles-in-breast-carcinoma-with-signet-ring-cells-a-clinicopathological-study
#6
Ryuji Ohashi, Ayako Hayama, Keiko Yanagihara, Koji Yamashita, Takashi Sakatani, Hiroyuki Takei, Zenya Naito
BACKGROUND: Signet ring cells (SRCs) often accompany gastrointestinal carcinoma, referred to as SRC carcinoma; however, breast cancers containing SRCs have not been well characterized, leaving the prognostic significance of SRCs undetermined. We have described clinicopathological characteristics of patients with breast cancer containing SRCs in relation to the expression levels of MUC1, MUC2, MUC4, MUC5AC, and MUC6. METHODS: Twenty-two breast cancer cases with variable degrees of SRC population were retrospectively studied...
November 15, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27845589/abnormalities-in-muc5ac-and-muc5b-protein-in-airway-mucus-in-asthma
#7
Marrah E Lachowicz-Scroggins, Shaopeng Yuan, Sheena C Kerr, Eleanor M Dunican, Michelle Yu, Stephen D Carrington, John V Fahy
No abstract text is available yet for this article.
November 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27845339/a-combination-of-muc5ac-and-ca19-9-improves-the-diagnosis-of-pancreatic-cancer-a-multicenter-study
#8
Sukhwinder Kaur, Lynette M Smith, Asish Patel, Melanie Menning, Duncan C Watley, Saad S Malik, Shiv Ram Krishn, Kavita Mallya, Abhijit Aithal, Aaron R Sasson, Sonny L Johansson, Maneesh Jain, Shailender Singh, Sushovan Guha, Chandrakanth Are, Massimo Raimondo, Michael A Hollingsworth, Randall E Brand, Surinder K Batra
OBJECTIVES: Pancreatic cancer (PC) is a lethal malignancy that lacks specific diagnostic markers. The present study explores the diagnostic potential of the most differentially overexpressed secretory mucin MUC5AC alone and in combination with CA19-9 using multi-center training and validation sets. METHODS: The expression of MUC5AC in benign pancreatic pathologies, PC precursor lesions, primary PC tissues and metastatic lesions was evaluated by immunohistochemistry...
November 15, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27816419/ectopic-gastric-and-intestinal-phenotypes-neuroendocrine-cell-differentiation-and-sox2-expression-correlated-with-early-tumor-progression-in-colorectal-laterally-spreading-tumors
#9
Takahito Katano, Tsutomu Mizoshita, Hironobu Tsukamoto, Hirotada Nishie, Yusuke Inagaki, Noriyuki Hayashi, Satoshi Nomura, Keiji Ozeki, Yasuyuki Okamoto, Takaya Shimura, Yoshinori Mori, Eiji Kubota, Satoshi Tanida, Hiromi Kataoka, Toshiya Kuno, Satoru Takahashi, Takashi Joh
INTRODUCTION: The significance of the ectopic gastric phenotype remains unclear in patients with colorectal laterally spreading tumors (LSTs). We investigated clinicopathologic differences among LST subtypes, aiming to identify factors indicative of malignant transformation and invasion that are linked to ectopic gastric phenotype and tumor progression. MATERIALS AND METHODS: We analyzed the morphologic characteristics of 105 colorectal LSTs resected by endoscopic submucosal dissection...
October 6, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27809484/characterizing-protein-glycosylation-through-on-chip-glycan-modification-and-probing
#10
Bryan S Reatini, Elliot Ensink, Brian Liau, Jessica Y Sinha, Thomas W Powers, Katie Partyka, Marshall Bern, Randall E Brand, Pauline Mary Rudd, Doron Kletter, Richard R Drake, Brian B Haab
Glycans are critical to protein biology and are useful as disease biomarkers. Many studies of glycans rely on clinical specimens, but the low amount of sample available for some specimens limits the experimental options. Here we present a method to obtain information about protein glycosylation using a minimal amount of protein. We treat proteins that were captured or directly spotted in small microarrays (2.2 x 2.2 mm) with exoglycosidases to successively expose underlying features, and then we probe the native or exposed features using a panel of lectins or glycan-binding reagents...
November 3, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27795812/mucins-in-neoplasms-of-pancreas-ampulla-of-vater-and-biliary-system
#11
REVIEW
Dimitrios Moschovis, Giorgos Bamias, Ioanna Delladetsima
Tumors of the pancreas, the ampulla of Vater, and the extrahepatic and intrahepatic bile ducts have significant histological similarities due to the common embryonic origin of the pancreatobiliary system. This obviates the need for discovery of biomarkers with diagnostic and prognostic value for these tumors. Mucins, especially MUC-1, -2, -4 and -5AC, are important candidates for developing into such reliable biomarkers. Increased expression of MUC1 occurs in pancreatic ductal adenocarcinomas and is associated with increased degrees of dysplasia in pancreatic intraepithelial neoplasia (PanIN)...
October 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27794589/tilianin-inhibits-muc5ac-expression-mediated-via-down-regulation-of-egfr-mek-erk-sp1-signaling-pathway-in-nci-h292-human-airway-cells
#12
Won-Yong Song, Yong-Seok Song, Hyung Won Ryu, Sei-Ryang Oh, JinTae Hong, Do-Young Yoon
In human airway, mucus exists to protect respiratory system as a primary barrier of innate immune system. However, hyper-expressed mucus limits airflow, resulting in decrease of lung function. Among more than 20 mucin family, MUC5AC and MUC5B are major glycoproteins in human airway mucus. Epidermal growth factor receptor (EGFR) signaling pathway is one of the mechanisms of these mucins expression and Specificity protein-1 (Sp1) transcription factor is the downstream signal of this pathway, playing pivotal roles in mucin expression...
October 28, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27791390/immediate-effect-of-3-diquafosol-ophthalmic-solution-on-tear-muc5ac-concentration-and-corneal-wetting-ability-in-normal-and-experimental-keratoconjunctivitis-sicca-rat-models
#13
Kwang-Eon Choi, Jong-Suk Song, Boram Kang, Youngsub Eom, Hyo-Myung Kim
PURPOSE: To evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear MUC5AC concentration, periodic acid-Schiff (PAS)-positive goblet cells, and tear film stability in normal and keratoconjunctivitis sicca (KCS) rat models. METHODS: Rats were divided into normal and KCS groups. 3% of diquafosol solution was instilled into the right eye and normal saline into the left eye in both groups. To determine the peak time of tear MUC5AC concentration, tears were collected after 3% diquafosol instillation every 5 min up to 20 min...
October 28, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27780139/platycodin-d-inhibits-interleukin-13-induced-the-expression-of-inflammatory-cytokines-and-mucus-in-nasal-epithelial-cells
#14
Botao Wang, Ying Gao, Guoxi Zheng, Xiaoyong Ren, Bin Sun, Kang Zhu, Huanan Luo, Zhenghui Wang, Min Xu
Allergic rhinitis (AR) is a common chronic inflammatory condition of the nasal mucosal tissue. Platycodin D (PLD), a triterpenoid saponin isolated from the root of Platycodon grandiflorum, has anti-inflammatory effects in a mouse model of allergic asthma. However, the anti-inflammatory effects of PLD in the nasal mucosa have not been deeply investigated. The objective was to investigate the effect of PLD on inflammatory cytokines and mucus production from nasal epithelial cells. Our study showed that PLD inhibited the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) and eotaxin in interleukin (IL)-13-stimulated RPMI2650 cells...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27776277/interleukin-33-induces-mucin-gene-expression-and-goblet-cell-hyperplasia-in-human-nasal-epithelial-cells
#15
Hajime Ishinaga, Masako Kitano, Masaaki Toda, Corina N D'Alessandro-Gabazza, Esteban C Gabazza, Said Ahmad Shah, Kazuhiko Takeuchi
We investigated whether IL-33 is involved in mucus overproduction and goblet cell hyperplasia in eosinophilic chronic rhinosinusitis (ECRS). IL-33 mRNA was significantly higher in the eosinophilic CRS group than in the non-eosinophilic CRS group from human nasal polyps. IL-33 induced MUC5AC mRNA and MUC5AC protein, and also goblet cell hyperplasia at air liquid interface culture in human nasal epithelial cells. In addition to that, IL-33 induced MUC5B and FOXA3, and reduces FOXJmRNA. In conclusion, our present study demonstrated that the direct evidence of IL-33 which lead to increase mucin gene and protein expression, as well as goblet cell hyperplasia...
October 21, 2016: Cytokine
https://www.readbyqxmd.com/read/27766003/dynamics-of-sox2-and-cdx2-expression-in-barrett-s-mucosa
#16
Rita Barros, Daniela Pereira, Catarina Callé, Vânia Camilo, Ana Isabel Cunha, Leonor David, Raquel Almeida, António Dias-Pereira, Paula Chaves
Barrett's esophagus (BE) is the replacement of the normal esophageal squamous epithelium by a columnar lining epithelium. It is a premalignant condition for the development of adenocarcinoma of the esophagus and esophagogastric junction. BE is associated with gastroesophageal reflux which might change the expression profile of key transcription factors involved in the establishment of tissue differentiation, namely, SOX2 (associated with esophageal and gastric differentiation) and CDX2 (associated with intestinal differentiation)...
2016: Disease Markers
https://www.readbyqxmd.com/read/27756631/presence-of-dna-extracellular-traps-but-not-muc5ac-and-muc5b-mucin-in-mucoid-plugs-casts-of-infectious-laryngotracheitis-virus-iltv-infected-tracheas-of-chickens
#17
Vishwanatha R A P Reddy, Ivan Trus, Hans J Nauwynck
Although it has been speculated that the tracheal obstructions and asphyxiation during acute infectious laryngotracheitis (ILT) are due to mucoid plugs/casts formed by mucus hypersecretion, there are no reports demonstrating this. Hence, in the present study, we first examined if the main respiratory mucins, MUC5AC and MUC5B, are expressed in the mucosae of larynx, trachea and bronchi of mock-inoculated and ILTV infected chickens. Second, the tracheas with plugs/casts were stained for mucins (MUC5AC and MUC5B) and nuclear material (traps)...
January 2, 2017: Virus Research
https://www.readbyqxmd.com/read/27740966/-simple-mucinous-cyst-of-the-pancreas-a-clinicopathologic-analysis-of-39-examples-of-a-diagnostically-challenging-entity-distinct-from-intraductal-papillary-mucinous-neoplasms-and-mucinous-cystic-neoplasms
#18
Alyssa M Krasinskas, Gerard J Oakley, Pelin Bagci, Kee-Taek Jang, Shih-Fan Kuan, Michelle D Reid, Ipek Erbarut, Volkan Adsay
Pancreatic cysts >1 cm lined by nonpapillary mucinous epithelium without ovarian-type stroma pose diagnostic challenges. The term "simple mucinous cyst" was recently proposed for this entity. Our goal was to determine the clinicopathologic characteristics of these cysts, as they have not been previously described. Of the 39 patients with pancreatic resections included in this study, the mean age was 65 years and the female-to-male ratio was 4:1. The characteristics of the cysts are as follows: 82% had elevated cyst fluid carcinoembryonic antigen levels, 67% were unilocular, 69% occurred in the body/tail, 92% did not communicate with pancreatic ducts, the mean size was 2...
October 12, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27739441/non-ampullary-duodenal-carcinomas-clinicopathologic-analysis-of-47-cases-and-comparison-with-ampullary-and-pancreatic-adenocarcinomas
#19
Yue Xue, Alessandro Vanoli, Serdar Balci, Michelle M Reid, Burcu Saka, Pelin Bagci, Bahar Memis, Hyejeong Choi, Nobuyike Ohike, Takuma Tajiri, Takashi Muraki, Brian Quigley, Bassel F El-Rayes, Walid Shaib, David Kooby, Juan Sarmiento, Shishir K Maithel, Jessica H Knight, Michael Goodman, Alyssa M Krasinskas, Volkan Adsay
Literature on non-ampullary-duodenal carcinomas is limited. We analyzed 47 resected non-ampullary-duodenal carcinomas. Histologically, 78% were tubular-type adenocarcinomas mostly gastro-pancreatobiliary type and only 19% pure intestinal. Immunohistochemistry (n=38) revealed commonness of 'gastro-pancreatobiliary markers' (CK7 55, MUC1 50, MUC5AC 50, and MUC6 34%), whereas 'intestinal markers' were relatively less common (MUC2 36, CK20 42, and CDX2 44%). Squamous and mucinous differentiation were rare (in five each); previously, unrecognized adenocarcinoma patterns were noted (three microcystic/vacuolated, two cribriform, one of comedo-like, oncocytic papillary, and goblet-cell-carcinoid-like)...
October 14, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27729120/younger-patients-with-come-are-more-likely-to-have-mucoid-middle-ear-fluid-containing-mucin-muc5b
#20
Vanessa Duah, Zhen Huang, Stephanie Val, Christie DeMason, Marain Poley, Diego Preciado
BACKGROUND: Chronic otitis media (COM) is one of the most common childhood diseases. Its pathophysiology is complex and multifactorial. The role of specific mucin glycoprotein subtypes in OM is only recently being elucidated. OBJECTIVE: To determine the relationship between middle ear fluid mucins and clinical variables of patients needing tympanostomy tubes (TT). METHODS: Middle ear effusions (MEE) from children receiving TT were collected over a 2-year period...
November 2016: International Journal of Pediatric Otorhinolaryngology
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