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Muc5ac

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https://www.readbyqxmd.com/read/29145864/intraductal-tubulopapillary-neoplasm-itpn-of-the-pancreas-associated-with-an-invasive-component-a-case-report-with-review-of-the-literature
#1
Stefanie Kuscher, Hartmut Steinle, Afschin Soleiman, Dietmar Öfner, Stefan Schneeberger, Georg Oberhuber
BACKGROUND: Intraductal tubulopapillary neoplasm (ITPN) depicts a distinct entity in the subgroup of premalignant epithelial tumors of the pancreas. Although the histomorphological and immunophenotypical characterization of ITPN has been described by several authors in terms of report of case series in the past, the rarity of that tumor subtype and similarity to other entities still makes identification of ITPN a challenge for radiologists and pathologists. To date, little is known about tubulopapillary carcinoma that can evolve from ITPN...
November 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29139058/expression-and-serum-levels-of-mucin-5ac-muc5ac-as-a-biomarker-for-cholangiocarcinoma-a-meta-analysis
#2
Noel Pabalan, Sutawadee Sukcharoensin, Kritiya Butthongkomvong, Hamdi Jarjanazi, Veerachai Thitapakorn
AIM: The potential of biomarkers in detecting early cholangiocarcinoma (CCA) is facilitated by examining CCA-associated proteins from primary studies. One such protein is mucin 5AC (MUC5AC) but inconsistency of reported associations between its expression/serum levels and CCA prompts a meta-analysis to obtain more precise estimates. METHODS: A literature search yielded 17 included articles where multiple data in some raised the number of studies to 22. We calculated pooled odds ratios (OR) and 95% confidence intervals from negative and positive readings of MUC5AC levels...
November 15, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29132433/impaired-ciliogenesis-in-differentiating-human-bronchial-epithelia-exposed-to-non-cytotoxic-doses-of-multi-walled-carbon-nanotubes
#3
Ryan J Snyder, Salik Hussain, Charles J Tucker, Scott H Randell, Stavros Garantziotis
BACKGROUND: Multi-walled carbon nanotubes (MWCNTs) are engineered nanomaterials used for a variety of industrial and consumer products. Their high tensile strength, hydrophobicity, and semi-conductive properties have enabled many novel applications, increasing the possibility of accidental nanotube inhalation by either consumers or factory workers. While MWCNT inhalation has been previously shown to cause inflammation and pulmonary fibrosis at high doses, the susceptibility of differentiating bronchial epithelia to MWCNT exposure remains unexplored...
November 13, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29129801/activating-prostaglandin-e2-receptor-subtype-ep4-increases-secreted-mucin-from-airway-goblet-cells
#4
Tomohiro Akaba, Kosaku Komiya, Isao Suzaki, Yuji Kozaki, Jun Tamaoki, Bruce K Rubin
Prostaglandin E2 (PGE2) is a ligand of the E-type prostanoid receptors, EP1-4. PGE2 secretion is increased in the airways of patients with asthma by secretory phospholipases A2, which also increases MUC5AC mucin in goblet cells. We hypothesized that PGE2 would also increase MUC5AC mRNA and secreted protein through specific EP receptor activation. We sought to assess the effect of specific EP receptor activation on MUC5AC secretion from ciliated-enriched cells or goblet-enriched cells induced by IL-13. We develop an enriched goblet cell epithelium by growing normal human bronchial epithelial cells at air liquid interface for 14 days in the presence of IL-13...
November 9, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29128682/randomized-double-masked-trial-of-eyelid-cleansing-treatments-for-blepharitis
#5
Justin Sung, Michael T M Wang, Sang H Lee, Isabella M Y Cheung, Salim Ismail, Trevor Sherwin, Jennifer P Craig
PURPOSE: To compare the efficacy of a dedicated eyelid cleanser and diluted baby shampoo in the management of blepharitis. METHODS: Forty-three participants with clinical blepharitis signs were enrolled in a prospective, randomized, double-masked, paired-eye trial. A dedicated eyelid cleanser (TheraTears(®) SteriLid(®)) was applied to the eyelids of one eye (randomized) and diluted baby shampoo (Johnson's(®) No More Tears(®)) to the fellow eye, twice daily for 4 weeks...
November 8, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29112967/expression-patterns-of-conjunctival-mucin-5ac-and-aquaporin-5-in-response-to-acute-dry-eye-stress
#6
Dhruva Bhattacharya, Li Yu, Mingwu Wang
The relationship between aquaporin (AQP) 5 and mucin (MUC) 5AC in the conjunctiva was investigated in response to acute dry eye (DE) stress. A mixed-mechanism rabbit DE model, in which the main lacrimal gland, Harderian gland, and nictitating membrane were resected, was further explored in this study. Conjunctival impression cytology specimens were harvested before excision (BE) and up to 3 months after excision (AE) in 8 (16 eyes) male New Zealand White rabbits, and immunoblotting was employed to assess the expression of AQP5 and MUC5AC...
2017: PloS One
https://www.readbyqxmd.com/read/29070458/-receptor-for-advanced-glycation-end-products-upregulates-muc5ac-expression-and-promotes-mucus-overproduction-in-mice-with-toluene-diisocyanate-induced-asthma
#7
Jing Xiong, Wen-Qu Zhao, Guo-Hua Huang, Li-Hong Yao, Hang-Ming Dong, Chang-Hui Yu, Hai-Jin Zhao, Shao-Xi Cai
OBJECTIVE: To explore the role of the receptor for advanced glycation end products (RAGE) in regulating the expression of MUC5AC and mucus production in a mouse model of toluene diisocyanate (TDI)?induced asthma. METHODS: BALB/c mice were randomly divided into control group, vehicle (AOO) group, TDI?induced asthma group and RAGE inhibitor (FPS?ZM1) group. PAS staining, Western blotting, and immunohistochemistry were used to analyze the changes in mucus production and MUC5AC expression in the airway of the mice, and the expression of p?ERK was detected with Western blotting...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29053025/e-cigarette-use-causes-a-unique-innate-immune-response-in-the-lung-involving-increased-neutrophilic-activation-and-altered-mucin-secretion
#8
Boris Reidel, Giorgia Radicioni, Phillip Clapp, Amina A Ford, Sabri Abdelwahab, Meghan E Rebuli, Prashamsha Haridass, Neil E Alexis, Ilona Jaspers, Mehmet Kesimer
RATIONALE: E-cigarettes have become increasingly popular and little is known about their potential adverse health effects. OBJECTIVE: To determine the effects of e-cigarette use on the airways. METHODS: Induced sputum samples from cigarette smokers, e-cigarette users, and non-smokers, were analyzed by quantitative proteomics, and the total and individual concentrations of mucins MUC5AC and MUC5B were determined by light scattering/refractometry and labeled mass spectrometry, respectively...
October 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29031476/il-1%C3%AE-upregulates-muc5ac-expression-via-nf-%C3%AE%C2%BAb-induced-hif-1%C3%AE-in-asthma
#9
Shouzhen Wu, Hailong Li, Lijuan Yu, Ning Wang, Xu Li, Wei Chen
The manifest and important feature in respiratory diseases, including asthma and COPD (chronic obstructive pulmonary disease), is the increased numbers and hypersecretion of goblet cells and overexpression of mucins, especially Muc5ac. Many proinflammatory cytokines play important roles in goblet cell metaplasia and overproduction of Muc5ac. However, the effect of IL-1β on Muc5ac expression in asthma remains unknown. Here, we detected the correlation between IL-1β and Muc5ac in asthma patients and further explored the mechanism of IL-1β-induced Muc5ac overexpression...
October 12, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29031394/the-role-of-cysteinyl-leukotrienes-and-their-receptors-in-refractory-nasal-polyps
#10
Jintao Du, Luo Ba, Jiao Zhou, Lingyu Yu, Ruowu Liu, Jie Zhang, Feng Liu, Junming Xian, Shixi Liu, Yafeng Liu
Leukotriene signaling is essential in many diseases, including asthma, allergic rhinitis, atherosclerosis and inflammatory bowel disease. Nevertheless, the expression of cysteinyl leukotrienes (CysLTs) and its receptors (CYSLTRs) in different types of nasal polyps (NPs), and the role of their antagonist in the treatment of refractory chronic rhinosinusitis with nasal polyps (CRSwNP) are not well understood. The following study investigates the expression of CysLTs and CYSLTRs in different types of NPs, as well as the role of leukotriene receptor antagonist (montelukast) in refractory NPs...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29021452/a-case-of-familial-adenomatous-polyposis-with-multiple-helicobacter-negative-early-gastric-cancers-treated-by-endoscopic-submucosal-dissection
#11
Katsuki Yaguchi, Makomo Makazu, Kingo Hirasawa, Makoto Sugimori, Ryosuke Kobayashi, Chiko Sato, Ryosuke Ikeda, Takehide Fukuchi, Yasuaki Ishii, Hiroaki Kaneko, Wataru Shibata, Shoji Yamanaka, Yoshiaki Inayama, Shin Maeda
Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for MUC2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28986735/no2-inhalation-enhances-asthma-susceptibility-in-a-rat-model
#12
Ming Han, Xiaotong Ji, Guangke Li, Nan Sang
Nitrogen dioxide (NO2) is a major air pollutant. Epidemiologic studies have found that NO2 exposure is associated with an increased risk of asthma. Nevertheless, the potential molecular mechanisms remain unclear. In this study, we investigated the effect of NO2 inhalation on the occurrence of allergic airway inflammation and its underlying mechanisms. Firstly, male Wistar rats were exposed to 2 and 5 mg/m(3) NO2 (28 days, 5 h/day). The results showed that NO2 exposure could induce pulmonary inflammatory response, mucus formation, and Th1/Th2 imbalance in the lung of normal rats, resulting in allergic asthma-like features...
October 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28985745/mucus-and-mucins-do-they-have-a-role-in-the-inhibition-of-the-human-immunodeficiency-virus
#13
REVIEW
Anwar Suleman Mall, Habtom Habte, Yolanda Mthembu, Julia Peacocke, Corena de Beer
BACKGROUND: Mucins are large O-linked glycosylated proteins which give mucus their gel-forming properties. There are indications that mucus and mucins in saliva, breast milk and in the cervical plug inhibit the human immunodeficiency virus (HIV-1) in an in vitro assay. Crude mucus gels form continuous layers on the epithelial surfaces of the major internal tracts of the body and protect these epithelial surfaces against aggressive luminal factors such as hydrochloric acid and pepsin proteolysis in the stomach lumen, the movement of hard faecal pellets in the colon at high pressure, the effects of shear against the vaginal epithelium during intercourse and the presence of foreign substances in the respiratory airways...
October 6, 2017: Virology Journal
https://www.readbyqxmd.com/read/28952513/use-of-recombinant-mucin-glycoprotein-to-assess-the-interaction-of-the-gastric-pathogen-helicobacter-pylori-with-the-secreted-human-mucin-muc5ac
#14
Ciara Dunne, Anthony McDermot, Kumar Anjan, Aindrias Ryan, Colm Reid, Marguerite Clyne
There is intense interest in how bacteria interact with mucin glycoproteins in order to colonise mucosal surfaces. In this study, we have assessed the feasibility of using recombinant mucin glycoproteins to study the interaction of the gastric pathogen Helicobacter pylori with MUC5AC, a mucin which the organism exhibits a distinct tropism for. Stable clonal populations of cells expressing a construct encoding for a truncated version of MUC5AC containing N- and C-termini interspersed with two native tandem repeat sequences (N + 2TR + C) were generated...
April 15, 2017: Bioengineering
https://www.readbyqxmd.com/read/28946937/airborne-particulate-matter-increases-muc5ac-expression-by-downregulating-claudin-1-expression-in-human-airway-cells
#15
Sang-Su Kim, Cheol Hong Kim, Ji Wook Kim, Hsi Chiang Kung, Tae Woo Park, Yu Som Shin, Ju Deok Kim, Siejeong Ryu, Wang-Joon Kim, Yung Hyun Choi, Kyoung Seob Song
CLB2.0, a constituent of PM, induces secretion of multiple cytokines and chemokines that regulate airway inflammation. Specifically, IL-6 upregulates CLB2.0-induced MUC5AC and MUC1 expression. Interestingly, of the tight junction proteins examined, claudin-1 expression was inhibited by CLB2.0. While the overexpression of claudin-1 decreased CLB2.0-induced MUC5AC expression, it increased the expression of the anti-inflammatory mucin, MUC1. CLB2.0-induced IL-6 secretion was mediated by ROS. The ROS scavenger N-acetyl-cysteine inhibited CLB2...
September 26, 2017: BMB Reports
https://www.readbyqxmd.com/read/28944827/cerebral-ischemia-reperfusion-injury-induces-airway-mucus-hypersecretion-in-rats-and-activates-il%C3%A2-13%C3%A2-associated-inflammatory-mechanisms
#16
Baoning Xu, Lei Zhang, Yuqin Che, Chengyang Song, Wenjun Jiang, Jianhua Fan, Dali Tian
The majority of patients that suffer a stroke have excessive sputum, which accelerates the development of pulmonary complications. However, it is unclear whether cerebral ischemia and reperfusion (I/R) injury induces mucus hypersecretion, and the potential role of inflammation remains unknown. In the present study, the reversible middle cerebral artery occlusion model was applied in rats to induce cerebral I/R injury. The rats were grouped according to the duration of reperfusion (6, 12, 24, 48 and 72 h). Neurological dysfunction was evaluated by Longa scoring and lung dry‑to‑wet weight (dw/ww) ratios were determined to reflect the degree of mucus secretion...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28942146/leptin-positively-regulates-muc5ac-production-and-secretion-induced-by-interleukin-13-in-human-bronchial-epithelial-cells
#17
Wanming Hao, Jing Wang, Yu Zhang, Yunying Wang, Lixin Sun, Wei Han
Mucus hypersecretion and plugging of lower respiratory tract airways due to mucus plugs have long been recognized as the leading cause of the morbidity and mortality in asthma. MUC5AC protein is a major component of airway mucus. Here, we showed that interleukin (IL)-13 induced MUC5AC production and secretion, and leptin expression in the human bronchial epithelial cell line-16 (HBE16) cells in a concentration-dependent manner. Leptin knockdown suppressed MUC5AC production and secretion induced by IL-13. We further investigated the molecular mechanism by which leptin functioned, and found that leptin regulated IL-13-induced MUC5AC production and secretion via the JAK2-STAT3 pathway...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28938681/high-mucin-5ac-expression-predicts-adverse-postoperative-recurrence-and-survival-of-patients-with-clear-cell-renal-cell-carcinoma
#18
Haijian Zhang, Yidong Liu, Huyang Xie, Weisi Liu, Qiang Fu, Dengfu Yao, Jiejie Xu, Jianxin Gu
BACKGROUND: Mucin 5AC (MUC5AC), as a member of secreted/gel-forming mucin family, was frequently found to be abnormally expressed in inflammation or malignant diseases. However, the clinic pathologic features and prognostic values of MUC5AC in clear-cell renal cell carcinoma (ccRCC) have not been reported up to now. METHODS: MUC5AC expression was analyzed by immunohistochemistry on tissue microarrays. Kaplan-Meier survival curves, Univariate and Multivariate Cox analysis and newly-established nomogram model were performed to evaluate the prognostic value...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28935465/snhg16-indicates-a-poor-prognosis-and-affects-cell-proliferation-migration-and-invasion-in-non-small-cell-lung-cancer
#19
Wei Han, Xuemei Du, Jing Wang, Lixin Sun, Yongchun Li
In this study, we report that long non-coding RNA (lncRNA) SNHG16 is upregulated in non-small cell lung cancer (NSCLC) tissues, and is correlated with tumor size, TNM stage and lymph node metastasis. Kaplan-Meier analysis shows that the patients with high SNHG16 expression have poorer disease-free survival (DFS) and overall survival (OS) than the patients with low SNHG16 expression. Multivariate Cox regression analysis reveals that SNHG16 expression could be regarded as an independent predictor for DFS and OS in NSCLC patients...
September 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28932196/-epigallocatechin-3-gallate-reduces-cigarette-smoke-induced-airway-neutrophilic-inflammation-and-mucin-hypersecretion-in-rats
#20
Yingmin Liang, Kenneth W K Liu, Sze C Yeung, Xiang Li, Mary S M Ip, Judith C W Mak
Background: Cigarette smoking is the leading cause of chronic obstructive pulmonary disease. (-)-Epigallocatechin-3-gallate (EGCG), the major catechins in Chinese green tea, has been studied for its anti-oxidative and anti-inflammatory properties in cell and animal models. In this study, we aimed to analyze the effects of EGCG on cigarette smoke (CS)-induced airway inflammation and mucus secretion in the CS-exposed rat model. Methods: Male Sprague-Dawley rats were randomly divided into either sham air (SA) or CS exposure...
2017: Frontiers in Pharmacology
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