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Head and neck oncology

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https://www.readbyqxmd.com/read/28411387/prophylactic-dissection-of-level-v-in-primary-mucosal-scc-in-the-clinically-n-positive-neck-a-systematic-review
#1
REVIEW
Timothy McLean, Stephen J Kerr, Charles E B Giddings
OBJECTIVE: To review the evidence for level V dissection in the management of previously untreated mucosal squamous cell carcinoma (SCC) of the head and neck presenting with nodal metastasis when level V is clinically uninvolved. DATA SOURCE: The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) were used to conduct a systematic review of the current literature, including all English language articles published after 1990. A literature search was performed on November 29, 2015, of Medline, EMBASE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and the Cochrane Library...
April 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28405520/the-immune-molecular-landscape-of-the-b7-and-tnfr-immunoregulatory-ligand-receptor-families-in-head-and-neck-cancer-a-comprehensive-overview-and-the-immunotherapeutic-implications
#2
Yu-Pei Chen, Jian Zhang, Ya-Qin Wang, Na Liu, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Jun Ma
The B7 family and tumor necrosis factor receptor (TNFR) superfamily play a vital role in the T-cell co-stimulatory and co-inhibitory pathways, regulating T-cell activation, tolerance, and exhaustion; therapeutic modulation of these pathways is translated into effective new cancer treatments. Better understanding of the immune molecular landscapes of the B7 and TNFR families would guide head and neck immuno-oncology clinical research. We performed comprehensive molecular profiling of 10 B7 and 6 TNFR family members in head and neck cancer...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28400428/suppression-of-lymphocyte-functions-by-plasma-exosomes-correlates-with-disease-activity-in-patients-with-head-and-neck-cancer
#3
Sonja Ludwig, Theofanis Floros, Marie-Nicole Theodoraki, Chang-Sook Hong, Edwin K Jackson, Stephan Lang, Theresa L Whiteside
Purpose: Head and neck cancers (HNC) often induce profound immunosuppression which contributes to disease progression and interferes with immune-based therapies. Body fluids of HNC patients are enriched in exosomes potentially engaged in negative regulation of anti-tumor immune responses. The presence and content of exosomes derived from plasma of HNC patients are evaluated for the ability to induce immune dysfunction and influence disease activity. <p>Experimental Design: Exosomes were isolated by size-exclusion chromatography from plasma of 38 HNC patients and 14 healthy donors...
April 11, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28400176/a-novel-method-to-evaluate-salivary-flow-rates-of-head-and-neck-cancer-patients-after-radiotherapy-a-pilot-study
#4
Luiz Felipe Palma, Fernanda Aurora Stabile Gonnelli, Marcelo Marcucci, Adelmo José Giordani, Rodrigo Souza Dias, Roberto Araújo Segreto, Helena Regina Comodo Segreto
INTRODUCTION: The procedure used to evaluate salivary flow rate is called sialometry. It can be performed through several techniques, but none appears to be really efficient for post-radiotherapy patients. OBJECTIVE: To adequate sialometry tests for head and neck cancer patients submitted to radiotherapy. METHODS: 22 xerostomic patients post-radiotherapy (total radiation dose ranging from 60 to 70Gy) were included in this study. Ten patients were evaluated using sialometries originally proposed by the Radiation Therapy Oncology Group and twelve were assessed by our modified methods...
March 25, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28399024/immediate-reconstruction-for-plantar-melanoma-a-paradigm-shift
#5
Hunter Oliver-Allen, Merisa Piper, Carolyn Vaughn, Hani Sbitany
INTRODUCTION: Plantar melanoma tumors are traditionally treated with wide local excision based on depth of invasion, followed by delayed reconstruction once negative surgical margins are confirmed. However, delayed reconstruction requires care for an open wound, a prolonged treatment course, and the need for an additional surgery. Immediate reconstruction has been shown to be oncologically safe in head and neck melanoma, but little is described in the literature regarding immediate reconstruction in plantar melanoma...
May 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28397585/survival-and-margin-status-in-head-and-neck-radiation-induced-sarcomas-and-de-novo-sarcomas
#6
Andrew J Rosko, Andrew C Birkeland, Steven B Chinn, Andrew G Shuman, Mark E Prince, Rajiv M Patel, Jonathan B McHugh, Matthew E Spector
Objective To describe histologic subtypes and oncologic outcomes among patients with radiation-induced and de novo sarcomas of the head and neck. Study Design Retrospective case series with chart review. Setting Tertiary academic center. Subject and Methods In total, 166 adult patients with sarcoma of the head and neck treated from January 1, 1985, to January 1, 2010, were included. Tumors were characterized as radiation induced (15.1%) vs de novo sarcomas (84.9%). Clinical and tumor characteristics were compared...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28397269/asian-and-non-asian-disparities-in-outcomes-of-non-nasopharyngeal-head-and-neck-cancer
#7
Jason D Kim, Jennifer T Chang, Ali Moghaddamjou, Emily A Kornelsen, Jenny Y Ruan, Robert A Olson, Winson Y Cheung
OBJECTIVES/HYPOTHESIS: To evaluate disparities in overall survival (OS) between Asian and non-Asian patients diagnosed with non-nasopharyngeal head and neck cancer (HNC). STUDY DESIGN: This was a population-based, retrospective study of patients diagnosed with non-nasopharyngeal HNC of squamous cell carcinoma histology between 2001 and 2010 in British Columbia, Canada. METHODS: Using Kaplan-Meier methods and Cox regression models, we examined the relationship between race and OS...
April 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28391578/feasibility-of-concurrent-chemoradiotherapy-with-high-dose-cisplatin-after-induction-tpf-chemotherapy-in-head-and-neck-cancer-a-critical-review-of-the-literature-and-the-experience-of-the-european-institute-of-oncology
#8
REVIEW
D Alterio, M Cossu Rocca, W Russell-Edu, S Dicuonzo, G Fanetti, G Marvaso, L Preda, S Zorzi, E Verri, F Nole', B A Jereczek-Fossa
Many concerns are related to the idea that the acute toxicity of induction chemotherapy (IC) performed with TPF (docetaxel, cisplatin, 5-fluorouracil) could reduce the ability to deliver the subsequent standard concurrent chemoradiotherapy (CRT) in head and neck cancer patients. We performed a critical review of the literature on the toxicity profile of the standard CRT administered after the IC with TPF. A total of 13 papers (including 950 patients) were selected. Results showed that most patients were treated with an adequate radiation total dose although a significant proportion of them (from 15 to 30%) completed the planned treatment with a delay of more than 5 days...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28390805/from-transmandibular-to-transoral-robotic-approach-for-parapharyngeal-space-tumors
#9
Francesco Chu, Marta Tagliabue, Gioacchino Giugliano, Luca Calabrese, Lorenzo Preda, Mohssen Ansarin
PURPOSE: Parapharyngeal space (PPS) tumors are rare, accounting for 0.5% of all head-and-neck masses. Surgery remains the standard treatment for most cases, including different approaches (cervical approach, parotidectomy, mandibulotomy, transoral/robotic). We report our experience in the management of PPS tumors, aiming to create a surgical algorithm on the base of tumor's radiological and clinical characteristics. MATERIALS AND METHODS: Critical retrospective analysis of patients with PPS neoplasms who underwent surgery at our Institute...
March 31, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28376165/current-state-of-pcr-based-epstein-barr-virus-dna-testing-for-nasopharyngeal-cancer
#10
Kelly Y Kim, Quynh-Thu Le, Sue S Yom, Benjamin A Pinsky, Scott V Bratman, Raymond H W Ng, Haja S El Mubarak, K C Allen Chan, Miriam Sander, Barbara A Conley
Clinical studies have shown plasma Epstein-Barr virus (EBV) DNA level to be an independent prognostic biomarker for nasopharyngeal carcinoma (NPC). However, the proportion of NPC patients whose tumors are associated with EBV vary with geographic location, and there are a variety of assays for plasma EBV. To develop the level of evidence needed to demonstrate the clinical utility of plasma EBV DNA detection for NPC patients and encourage widespread adoption of this biomarker test in clinical laboratories, validated harmonized assays are needed...
April 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28370570/unknown-primary-head-and-neck-squamous-cell-carcinoma-in-the-era-of-fluorodeoxyglucose-positron-emission-tomography-ct-and-intensity-modulated-radiotherapy
#11
Mischa de Ridder, Martin Klop, Olga Hamming-Vrieze, JanPaul de Boer, Bas Jasperse, Laura Smit, Wouter Vogel, Michiel van den Brekel, Abrahim Al-Mamgani
BACKGROUND: The diagnosis and treatment of head and neck carcinoma of unknown primary (CUP) have changed with the introduction of fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT and intensity-modulated radiotherapy (IMRT), with potential implications for outcome. METHODS: We conducted a retrospective analysis of 80 patients with head and neck CUP who were PET-staged and treated with curative intention using IMRT between 2006 and 2016 in the Netherlands Cancer Institute...
March 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/28366109/reflections-the-value-of-patient-support-groups
#12
Amanda Hu
A patient support group is defined as "a group of people with common experiences and concerns who provide emotional and moral support for one another." Support groups fulfill many functions: educating patients/family, sharing the illness experience, providing strength to its members, raising public awareness, and fundraising. Some research has shown an improvement in quality of life of patients with head and neck cancer who have participated in support groups. A wide variety of support groups are available for otolaryngology patients, ranging from head and neck oncology to tinnitus and spasmodic dysphonia...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28362572/indicators-for-enteral-nutrition-use-and-prophylactic-percutaneous-endoscopic-gastrostomy-placement-in-patients-with-head-and-neck-cancer-undergoing-chemoradiotherapy
#13
Nina C van der Linden, Annemieke Kok, Marja J Leermakers-Vermeer, Nicole M de Roos, Remco de Bree, Hester van Cruijsen, Chris H J Terhaard
BACKGROUND: Chemoradiotherapy (CRT) is a major risk factor for malnutrition and dehydration in patients with head and neck cancer. Enteral support is often needed, and a percutaneous endoscopic gastrostomy (PEG) is frequently placed. Specific indicators for PEG placement remain unclear. This study retrospectively determined which factors contributed to enteral nutrition (EN) use and PEG placement in a large patient group to gain insight on potential indicators for PEG placement protocol creation...
April 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28351562/prospective-evaluation-of-intensity-modulated-radiation-therapy-with-simultaneous-integrated-boost-imrt-sib-in-head-and-neck-squamous-cell-carcinoma-in-patients-not-suitable-for-chemo-radiotherapy
#14
Madhup Rastogi, Shantanu Sapru, Pooja Gupta, Ajeet Kumar Gandhi, Surendra P Mishra, Anoop K Srivastava, Rohini Khurana, Rahat Hadi, Kamal Sahni, Farzana S
BACKGROUND: With conformal radiotherapy techniques, acute and late toxicities can be reduced because of better dose conformity and reduced doses to normal tissue. With Intensity Modulated Radiation Therapy (IMRT) further dose escalation is possible and one of the methods is IMRT with simultaneous integrated boost (IMRT-SIB). AIM: To evaluate feasibility, toxicity patterns and loco-regional control rates of IMRT-SIB technique in head and neck cancer patients who are not suitable candidates for concurrent chemoradiation...
April 2017: Oral Oncology
https://www.readbyqxmd.com/read/28351561/salvage-surgery-in-recurrent-head-and-neck-squamous-cell-carcinoma-oncologic-outcome-and-predictors-of-disease-free-survival
#15
Marc Hamoir, Emma Holvoet, Jerôme Ambroise, Benoît Lengelé, Sandra Schmitz
OBJECTIVE: Salvage surgery in recurrent SCCHN is associated with poor outcomes. This study aimed to better identify suitable surgical candidates and those at high risk of new recurrence. MATERIALS AND METHODS: Single-center retrospective analysis of 109 patients undergoing salvage surgery for recurrent SCCHN. Univariate and multivariate analyses were used to identify prognostic factors affecting disease-free survival (DFS). RESULTS: The following factors showed a significant impact on DFS: Disease-free interval >6months [HR 0...
April 2017: Oral Oncology
https://www.readbyqxmd.com/read/28346771/cohort-study-of-oncologic-emergencies-in-patients-with-head-and-neck-cancer
#16
Cielito C Reyes-Gibby, Stephanie C Melkonian, Ehab Y Hanna, Sai-Ching J Yeung, Charles Lu, Mark S Chambers, Srinivas R Banala, Gary B Gunn, Sanjay S Shete
BACKGROUND: Treatments for head and neck squamous cell carcinoma (HNSCC) are associated with toxicities that lead to emergency department presentation. METHODS: We utilized data from an ongoing prospective cohort of newly diagnosed, previously untreated patients (N = 298) with HNSCC to evaluate the association between clinical and epidemiologic factors and risk for and frequency of emergency department presentation. Time to event was calculated from the date of treatment initiation to emergency department presentation, date of death, or current date...
March 27, 2017: Head & Neck
https://www.readbyqxmd.com/read/28332989/multicenter-study-of-carbon-ion-radiation-therapy-for-mucosal-melanoma-of-the-head-and-neck-subanalysis-of-the-japan-carbon-ion-radiation-oncology-study-group-j-cros-study-1402-hn
#17
Masashi Koto, Yusuke Demizu, Jun-Ichi Saitoh, Hiroaki Suefuji, Hiroshi Tsuji, Tomoaki Okimoto, Tatsuya Ohno, Yoshiyuki Shioyama, Ryo Takagi, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
PURPOSE: To evaluate the efficacy and safety of carbon-ion radiation therapy (RT) for mucosal melanoma of the head and neck (MMHN) in the Japan Carbon-Ion Radiation Oncology Study Group study. METHODS AND MATERIALS: Patients with MMHN with N0-1M0 status who were treated with carbon-ion RT at 4 institutions in Japan between November 2003 and December 2014 were analyzed retrospectively. Two hundred sixty patients (male, 111; female, 149; median age, 68 years) with histologically proven MMHN were enrolled...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28327089/uniform-fdg-pet-guided-gradient-dose-prescription-to-reduce-late-radiation-toxicity-upgrade-rt-study-protocol-for-a-randomized-clinical-trial-with-dose-reduction-to-the-elective-neck-in-head-and-neck-squamous-cell-carcinoma
#18
Sven van den Bosch, Tim Dijkema, Martina C Kunze-Busch, Chris H J Terhaard, Cornelis P J Raaijmakers, Patricia A H Doornaert, Frank J P Hoebers, Marije R Vergeer, Bas Kreike, Oda B Wijers, Wim J G Oyen, Johannes H A M Kaanders
BACKGROUND: In definitive radiation therapy for head and neck cancer, clinically uninvolved cervical lymph nodes are irradiated with a so-called 'elective dose' in order to achieve control of clinically occult metastases. As a consequence of high-resolution diagnostic imaging, occult tumor volume has significantly decreased in the last decades. Since the elective dose is dependent on occult tumor volume, the currently used elective dose may be higher than necessary. Because bilateral irradiation of the neck contributes to dysphagia, xerostomia and hypothyroidism in a dose dependent way, dose de-escalation to these regions can open a window of opportunity to reduce toxicity and improve quality of life after treatment...
March 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28324180/lateral-pharyngotomy-approach-in-the-treatment-of-oropharyngeal-carcinoma
#19
Andy Bertolin, Guido Ghirardo, Marco Lionello, Luciano Giacomelli, Marco Lucioni, Giuseppe Rizzotto
Surgery for early-intermediate oropharyngeal squamous cell carcinoma (OPSCC) may involve using transoral endoscopic approaches or open surgical procedures. "Lateral pharyngotomy" (LP) is an open surgical approach that improves exposure of the oropharyngeal region, while avoiding mandibulotomy. The aim of the present study was to retrospectively analyze our experience with the surgical treatment of early-intermediate OPSCC using the LP approach, and to investigate the potentially prognostic clinical and/or pathological factors that might identify patients at higher risk of recurrence after primary surgery...
March 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28322111/hpv-in-larynx-squamous-cell-carcinoma-new-serotypes-and-survival-study-within-10-year-follow-up
#20
Alvaro Sánchez Barrueco, Fernando González Galán, David Lora Pablos, José Miguel Villacampa Aubá, Claudio Ballestín Carcavilla, Carlos Cenjor Español, Carlos Almodóvar Álvarez
Objective To determine the presence of human papillomavirus (HPV) in head and neck squamous cell carcinoma, specifically in the larynx without the bias of other sublocations, and to describe the different serotypes of HPV and their impact on overall and disease-free survival after 10-year follow-up. Study Design Retrospective case series with chart review of ear, nose, and throat oncologic database. Setting Academic tertiary care hospital. Subjects A total of 123 samples of larynx squamous cell carcinoma were included, only from the glottis and treated only with surgery between 1977 and 2005...
March 1, 2017: Otolaryngology—Head and Neck Surgery
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