keyword
MENU ▼
Read by QxMD icon Read
search

Head and neck oncology

keyword
https://www.readbyqxmd.com/read/29669181/racial-disparity-in-oncologic-and-quality-of-life-outcomes-in-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinomas-enrolled-in-a-randomized-phase-2-trial
#1
Margaret K Guerriero, Mary W Redman, Kelsey K Baker, Renato G Martins, Keith Eaton, Laura Q Chow, Rafael Santana-Davila, Christina Baik, Bernardo H Goulart, Sylvia Lee, Cristina P Rodriguez
BACKGROUND: To better understand patient-reported quality of life (PRQOL) for patients with head and neck cancer, PRQOL scores were collected in a clinical trial. METHODS: Patients were randomized to arm A (70 Gy of radiation with cisplatin) or arm B (70 Gy of radiation with cisplatin plus erlotinib at 150 mg daily). PRQOL scores were measured on days -7 (arm B only), 0, 30, and 180 with the University of Washington Quality of Life Questionnaire. Associations with clinical factors and outcomes were explored with linear mixed, logistic, and Cox regression models...
April 18, 2018: Cancer
https://www.readbyqxmd.com/read/29662536/attrition-as-one-of-the-challenges-of-developing-a-palliative-care-centre-experience-of-the-indian-institute-of-head-and-neck-oncology-indore-india
#2
EDITORIAL
Digpal Dharkar
Palliative care is an essential component of health care delivery. With respect to India, currently, despite rapid socio economic development, there are tremendous challenges in offering institutional palliative care due to several factors. A major factor has been an acute shortage of trained palliative care professionals. Another has been the fact that the majority of India's population is not covered by any health insurance. We describe the problems, including attrition faced by the Indian Institute of Head and Neck Oncology, in the central Indian state of Madhya Pradesh...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29660835/pdgfra-mrna-overexpression-is-associated-with-regional-metastasis-and-reduced-survival-in-oral-squamous-cell-carcinoma
#3
Hui Shan Ong, Sandhya Gokavarapu, Zhen Tian, Jiang Li, Qin Xu, Chen Ping Zhang, Wei Cao
BACKGROUND: Platelet-derived growth factor alpha (PDGFRA) is a gene encoding tyrosine kinase receptor and both EGFR and PDGFRA activate tyrosine kinase. The implication of PGFRA in many cancers and its prognostic significance irrespective to EGFR status in spinal chordoma, gliomas and uterine cancers has shown a need for its investigation in oral squamous cell carcinoma (OSCC). We investigated the prognostic value of PDGFRA mRNA expression in OSCC. PATIENTS AND METHODS: The study was conducted in the department of oral maxillofacial surgery-head and neck oncology, at a tertiary hospital...
April 16, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29657686/extraskeletal-myxoid-chondrosarcoma-of-nasopharynx-an-oncologic-entity-rarely-reported
#4
Abhishek Purkayastha, Neelam Sharma, Vibha Dutta
Extraskeletal myxoid chondrosarcoma (ESMC) is an extremely rare variant of chondrosarcoma accounting for less than 10% cases. It affects mainly the soft tissues of the proximal end of long bones. Its incidence in the head and neck region is less than 5%. This case presented in the nasopharynx, an exceedingly unusual site for ESMC in a 60-year-old female with left-sided nasal obstruction and occasional epistaxis of one-year duration. Biopsy from the nasopharyngeal mass was suggestive of low-grade chondrosarcoma...
March 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29652817/selenium-in-radiation-oncology-15-years-of-experiences-in-germany
#5
REVIEW
Ralph Muecke, Oliver Micke, Lutz Schomburg, Jens Buentzel, Klaus Kisters, Irenaeus A Adamietz
Introduction: Se measurement and supplementation in radiation oncology is a controversial issue. The German Working Group Trace Elements and Electrolytes in Oncology (AKTE) has conducted a number of studies on this issue, which are summarized in this review. Strategies have been tested and developed, aiming to stratify the patients with a potential need for supplemental Se and how best to monitor Se supplementation with respect to health effects and risks. Methods: We analyzed blood and tissue Se-levels of different tumor patients ( n = 512)...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29650894/-chemoradiotherapy-the-standard-treatment-at-present
#6
Sadamoto Zenda
Chemotherapy concurrent with radiotherapy has been widely used in clinical practice because the additional benefit on radiotherapy alone had shown. Head and neck cancer: CDDP concurrent with radiotherapy has been a standard treatment for 15years both in definitive setting and postoperative setting. Esophageal cancer: 5-FU/CDDP is the best partner for radiotherapy and appropriate radiation dose has been discussed. Anal cancer: Radical concurrent chemoradiotherapy with 5-FU and mitomycin C(MMC)remains the standard of care for squamous cell carcinoma of the anus...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29644155/stereotactic-body-radiation-therapy-for-pulmonary-oligometastases-arising-from-non-lung-primaries-in-patients-without-extrapulmonary-disease
#7
Michael J Dohopolski, Zachary Horne, David Clump, Steven A Burton, Dwight E Heron
Purpose Stereotactic body radiation therapy (SBRT) is increasingly used in the management of patients with oligometastatic cancers and is under prospective evaluation by the Radiation Therapy Oncology Group (RTOG). Here we report outcomes from a high-volume institution of patients treated with SBRT for pulmonary oligometastases. Materials and methods We conducted a retrospective review of 105 patients who had one to five pulmonary oligometastases (185 lesions) without extrapulmonary disease treated with SBRT from 2002-2014...
February 7, 2018: Curēus
https://www.readbyqxmd.com/read/29642922/an-anterolateral-thigh-chimeric-flap-for-dynamic-facial-and-esthetic-reconstruction-after-oncological-surgery-in-the-maxillofacial-region-a-case-report
#8
Zoltán Lóderer, Tamás Vereb, Róbert Paczona, Ágnes Janovszky, József Piffkó
BACKGROUND: The surgical management of malignant tumors in the head and neck region often leads to functional and esthetic defects that impair the quality of life of the patients. Reconstruction can be solved with prostheses in these cases, but various types of microsurgical free flaps can provide a better clinical outcome. CASE PRESENTATION: In this case report, the tumor and parts of the involved facial muscles and nerve were excised surgically from a 42-year-old patient after a third relapse of basal cell carcinoma in the left midface...
April 11, 2018: Head & Face Medicine
https://www.readbyqxmd.com/read/29625723/infectious-complications-in-head-and-neck-surgery-porto-oncology-centre-retrospective-analysis
#9
Miguel Sá Breda, Joaquim Castro Silva, Eurico Monteiro
OBJECTIVE: To analyze the impact of infectious complications and microbiology in the postoperative period after major oncologic neck surgeries. METHODS: A retrospective study conducted in an oncology center, including all the consecutive patients who developed infectious complications after major neck cancer surgery, from October 2012 to May 2016 (44 months). Among other data, we collected TNM stage, ASA score, body mass index, comorbidities and habits, pre and postoperative hemoglobin levels, albumin serum levels, pre-surgical treatments, length of inpatient stay, isolated microbiological agents and the recorded complications and mortality rate...
April 3, 2018: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29625408/nutritional-intervention-in-head-and-neck-cancer-patients-during-chemo-radiotherapy
#10
Serena Della Valle, Silvia Colatruglio, Vanessa La Vela, Elena Tagliabue, Luigi Mariani, Cecilia Gavazzi
OBJECTIVE: Head and neck cancer patients experience unintentional weight loss and malnutrition at diagnosis, during oncologic treatment, and after the end of therapy because of reduction of eating ability. The aim of the present study was to assess nutrition intervention efficacy in maintaining basal nutritional conditions. METHODS: Head and neck cancer patient candidates for chemoradiotherapy and requiring enteral nutrition (EN) support through gastrostomy, according to international guidelines, were included in the study...
February 5, 2018: Nutrition
https://www.readbyqxmd.com/read/29616165/a-systematic-review-and-meta-analysis-of-free-style-flaps-risk-analysis-of-complications
#11
Youlei Qian, Guangxue Li, Huiran Zang, Saisai Cao, Yan Liu, Kai Yang, Lan Mu
Background: Free-style flaps allow surgeons to overcome anatomical variations and raise perforator flaps wherever a pulsatile signal can be detected. We performed a systematic review and meta-analysis to identify the risk factors for complications and indications for free-style flaps in soft-tissue defect reconstructions. Methods: This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The databases of MEDLINE, PubMed, ScienceDirect, and Cochrane Library were searched from January 1991 to January 2017 for original articles describing free-style flaps in soft-tissue defect reconstruction...
February 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29611749/-the-possible-role-of-the-timing-of-the-first-oncological-treatment-on-the-survival-rate-of-cancer-diseases-a-literature-overview
#12
László Mangel, Tamás Tornóczky, Antal Zemplényi, Imre Boncz
The aim of this study was to survey the effects of the waiting time for the first oncology treatment in cancer diseases. By the analysis of 67 retrospective studies and reviews the numerical effects of treatment initiation time on survival were assessed. The "time factor" has a leading role on cancer types with aggressive biological behaviour, like breast cancer in younger age, testicular cancers, or head and neck tumours. However, a few days and reasonable delay to the first oncology intervention has no negative impact in numerous cancer diseases...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29603669/practice-patterns-and-outcomes-of-chemoradiotherapy-versus-radiotherapy-alone-for-older-patients-with-nasopharyngeal-cancer
#13
Vivek Verma, Swati M Surkar, Amy C Moreno, Chi Lin, Charles B Simone
Older patients are at increased risk of toxicities from aggressive oncologic therapy and of nononcologic death. A meta-analysis of non-nasopharyngeal head and neck cancers showed no statistical benefit in adding chemotherapy to radiotherapy (RT) in older patients; another meta-analysis of RT versus chemoradiotherapy (CRT) in NPC found advantages to CRT, but vastly under-represented patients ≥70 years old. This is the largest study to date evaluating outcomes of CRT versus RT alone in this population. The National Cancer Data Base (NCDB) was queried for primary nasopharyngeal cancer cases (2004-2013) in patients ≥70 years old receiving RT alone or CRT...
March 30, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29602261/post-acute-care-use-after-major-head-and-neck-oncologic-surgery-with-microvascular-reconstruction
#14
Harman S Parhar, Brent A Chang, J Scott Durham, Donald W Anderson, Richard E Hayden, Eitan Prisman
OBJECTIVES: Post-acute care (PAC) centers, such as skilled nursing facilities, unskilled nursing facilities, lower acuity hospitals, and rehabilitation centers, serve to optimize recovery after acute care hospitalization. We aimed to identify factors associated with PAC utilization among patients undergoing head and neck cancer surgery with microvascular reconstruction because it may be helpful for patient decision making, discharge planning, and resource allocation. METHODS: Retrospective linked analysis of the 2011 to 2015 National Surgical Quality Improvement Program...
March 30, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29599409/functional-precision-medicine-identifies-novel-druggable-targets-and-therapeutic-options-in-head-and-neck-cancer
#15
Chang Xu, Olga Nikolova, Ryan Basom, Ryan M Mitchell, Reid Shaw, Russell Moser, Heuijoon Park, Kay E Gurley, Micheal Kao, Carlos L Green, Franz X Schaub, Robert L Diaz, Hallie A Swan, In Sock Jang, Justin Guinney, Vijayakrishna K Gadi, Adam A Margolin, Carla Grandori, Christopher J Kemp, Eduardo Méndez
PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with high mortality and a lack of targeted therapies. To identify and prioritize druggable targets, we performed genome analysis together with genome-scale siRNA and oncology drug profiling using low passage tumor cells derived from a patient with a treatmentresistant HPV-negative HNSCC. EXPERIMENTAL DESIGN: A tumor cell culture was established and subjected to whole exome sequencing, RNA sequencing, comparative genome hybridization, and high-throughput phenotyping with siRNA library covering the druggable genome and an oncology drug library...
March 29, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29599172/submandibular-gland-transfer-a-potential-imaging-pitfall
#16
X Wu, S S Yom, P K Ha, C M Heaton, C M Glastonbury
BACKGROUND AND PURPOSE: The Seikaly and Jha submandibular gland transfer surgery is performed to facilitate gland shielding during radiation therapy for head and neck tumors to circumvent radiation-induced xerostomia. It results in an asymmetric postsurgical appearance of the submandibular and submental spaces. Our purpose was to characterize the morphologic and enhancement characteristics of the transferred submandibular gland and identify potential pitfalls in postoperative radiologic interpretation...
March 29, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29598945/hyperglycemia-and-risk-of-adverse-outcomes-following-microvascular-reconstruction-of-oncologic-head-and-neck-defects
#17
Anaeze C Offodile, Hsuan-Yu Chou, Jennifer An-Jou Lin, Charles Yuen Yung Loh, Kai-Ping Chang, Mario A Aycart, Huang-Kai Kao
INTRODUCTION: Our aim is to examine the correlation between perioperative hyperglycemia and post-operative outcomes following microvascular reconstruction of head and neck defects. PATIENTS AND METHODS: Retrospective review of a prospectively collected database of 350 consecutive patients who underwent microvascular reconstruction of malignant head and neck defects over a 2 year period. The relationship between perioperative hyperglycemia (≥ 180 mg/dL) and the incidence of the following complications was evaluated: flap loss, flap-related complications and surgical site infections (SSI)...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29594852/information-architecture-for-a-patient-specific-dashboard-in-head-and-neck-tumor-boards
#18
Alexander Oeser, Jan Gaebel, Andreas Dietz, Susanne Wiegand, Steffen Oeltze-Jafra
PURPOSE: Overcoming the flaws of current data management conditions in head and neck oncology could enable integrated information systems specifically tailored to the needs of medical experts in a tumor board meeting. Clinical dashboards are a promising method to assist various aspects of the decision-making process in such cognitively demanding scenarios. However, in order to provide extensive and intuitive assistance to the participating physicians, the design and development of such a system have to be user-centric...
March 28, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29594239/the-posterior-cerebellum-a-new-organ-at-risk
#19
EDITORIAL
Daniëlle B P Eekers, Lieke In 't Ven, Sabine Deprez, Linda Jacobi, Erik Roelofs, Ann Hoeben, Philippe Lambin, Dirk de Ruysscher, Esther G C Troost
Eekers et al. have recently proposed a neuro-oncology atlas, which was co-authored by most centers associated in the European Proton Therapy Network (EPTN; Figure 1). With the introduction of new treatment techniques, such as integrated magnetic resonance imaging and linear accelerators (MR-linac) or particle therapy, the prediction of clinical efficacy of these more costly treatment modalities becomes more relevant. One of the side-effects of brain irradiation, being cognitive decline, is one of the toxicities most difficult to measure and predict...
January 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29594236/treatment-de-escalation-for-hpv-driven-oropharyngeal-cancer-where-do-we-stand
#20
REVIEW
Haitham Mirghani, Pierre Blanchard
HPV-driven oropharyngeal cancers have significantly better survival rates than tobacco and alcohol induced head and neck cancers. As HPV-positive patients are younger, healthier and far more likely to survive their disease, long-term treatment side effects are becoming a major issue. This has led the scientific and medical community to reassess the current treatment protocols in order to develop less toxic strategies while maintaining good oncological outcomes. In this article, we discuss the ongoing treatment de-escalation trials and highlight the issues raised by these studies...
January 2018: Clinical and Translational Radiation Oncology
keyword
keyword
19453
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"