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https://www.readbyqxmd.com/read/29901133/molecular-analysis-of-cypriot-families-with-aniridia-reveals-a-novel-pax6-mutation
#1
Andreas Syrimis, Nayia Nicolaou, Angelos Alexandrou, Ioannis Papaevripidou, Michael Nicolaou, Eleni Loukianou, Carolina Sismani, Stavros Malas, Violetta Christophidou-Anastasiadou, George A Tanteles
The present study investigated the clinical and mutational spectrum of aniridia in a cohort of 17 affected individuals from six families from Cyprus. Each proband was initially evaluated for copy number variants at the PAX6 locus and subsequently underwent PAX6 mutation screening. Sequence analysis of FOXC1 and PITX2 was performed in patients who did not carry a PAX6 mutation. The most common clinical features in the group of aniridia patients associated with aniridia were nystagmus, cataracts and glaucoma...
June 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29884889/forkhead-box-c1-promotes-colorectal-cancer-metastasis-through-transactivating-itga7-and-fgfr4-expression
#2
Jian Liu, Zhe Zhang, Xiaowei Li, Jie Chen, Guodong Wang, Zuhong Tian, Meirui Qian, Zhangqian Chen, Hao Guo, Guangbo Tang, Wenjie Huang, Dean Tian, Daowen Wang, Yongzhan Nie, Daiming Fan, Kaichun Wu, Limin Xia
Metastatic colorectal cancer (CRC) is one of the most common causes of cancer death worldwide; however, the molecular mechanism underlying CRC metastasis remains unknown. Using an integrated approach, we identified forkhead box C1 (FOXC1) as a novel regulator of CRC metastasis. Elevated expression of FOXC1 is significantly correlated with metastasis, recurrence and reduced survival. FOXC1 overexpression promotes CRC invasion and lung metastasis, whereas FOXC1 knockdown has the opposite effect. In addition, FOXC1 directly binds its target genes integrin α7 (ITGA7) and fibroblast growth factor receptor 4 (FGFR4) and activates their expression...
June 8, 2018: Oncogene
https://www.readbyqxmd.com/read/29864144/impact-of-ogt-deregulation-on-ezh2-target-genes-foxa1-and-foxc1-expression-in-breast-cancer-cells
#3
Ewa Forma, Paweł Jóźwiak, Piotr Ciesielski, Agnieszka Zaczek, Katarzyna Starska, Magdalena Bryś, Anna Krześlak
Enhancer of zest homolog 2 (EZH2) is a histone methyltransferase which plays a crucial role in cancer progression by regulation of genes involved in cellular processes such as proliferation, invasion and self-renewal. Activity and biological function of EZH2 are regulated by posttranslational modifications. It is suggested that EZH2 stability may be regulated by O-GlcNAc transferase (OGT), which is an enzyme catalyzing the addition of GlcNAc moieties to target proteins. In this study, we determined the impact of OGT on expression of EZH2 target genes FOXA1 and FOXC1, that are involved in breast cancer progression...
2018: PloS One
https://www.readbyqxmd.com/read/29847662/foxc1-regulates-expression-of-prostaglandin-receptors-leading-to-an-attenuated-response-to-latanoprost
#4
Lance P Doucette, Tim Footz, Michael A Walter
Purpose: This study examines the effect of FOXC1 on the prostaglandin pathway in order to explore FOXC1's role in the prostaglandin-resistant glaucoma phenotype commonly seen in Axenfeld-Rieger syndrome. Methods: Binding and transcriptional activity of FOXC1 to the gene coding for the EP3 prostaglandin receptor (PTGER3) were evaluated through ChIP-qPCR and luciferase-based assays. Immortalized trabecular meshwork cells (TM1) and HeLa cells had FOXC1 mRNA reduced via siRNA interference...
May 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29803789/circirak3-sponges-mir-3607-to-facilitate-breast-cancer-metastasis
#5
Jie Wu, Zerun Jiang, Chen Chen, Qingsong Hu, Ziyi Fu, Junjie Chen, Zhangding Wang, Qiang Wang, Aiping Li, Jeffrey R Marks, Changying Guo, Yun Chen, Jianwei Zhou, Liuqing Yang, Chunru Lin, Shouyu Wang
As a class of endogenous noncoding RNAs, circular RNAs (circRNAs) have been recently identified to regulate tumourigenesis and progression in multiple malignancies. However, the expression profiles and function of circRNAs in breast cancer metastasis are largely unknown. Here, we determined that the expression of a novel circRNA, which we named circIRAK3, was increased in metastatic breast cancer (BC) cells and predictive of BC recurrence. Gain-of-function and loss-of-function studies in BC cells demonstrated that circIRAK3 promoted cell migration, invasion and metastasis in vitro and in vivo but did not affect cell proliferation, colony formation or cell cycle progression...
August 28, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29754847/feasibility-of-classification-of-triple-negative-breast-cancer-by-immunohistochemical-surrogate-markers
#6
Sewha Kim, Byung-In Moon, Woosung Lim, Sanghui Park, Min Sun Cho, Sun Hee Sung
INTRODUCTION: Recently, Burstein et al identified 4 stable molecular subtypes of triple negative breast cancer (TNBC) by mRNA profiling: luminal androgen receptor (LAR), mesenchymal (MES), basal-like immune-activated (BLIA), and basal-like immune-suppressive (BLIS) types. The purpose of this study was to assess the feasibility of immunohistochemistry (IHC) surrogate panel in classifying the TNBC molecular subtypes using a large cohort of TNBC retrieved from a single institution. MATERIALS AND METHODS: IHC for androgen receptor [AR], claudin-3, E-cadherin, cytokeratin 5/6 [CK5/6], epidermal growth factor receptor [EGFR], indoleamine 2,3-dioxygenase 1 [IDO1], and Forkhead box C1 [FOXC1] were performed using the tissue microarray constructed from 200 TNBC samples...
March 23, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29751260/forkhead-box-c1-gene-variant-causing-glaucoma-and-small-vessel-angiopathy-can-mimic-multiple-sclerosis
#7
Jagannadha R Avasarala, Julie R Jones, Curtis R Rogers
A 34-year old Caucasian female was initially diagnosed with multiple small-vessel strokes at age 20 years which were etiologically classified as secondary to anti-phospholipid antibody syndrome (APS) although she had no history or laboratory data to suggest APS. Based on her MRI of brain findings, one of her neurologists was concerned she could have multiple sclerosis (MS) and hence the patient was referred to our clinic for further evaluation. The patient's MRI of brain showed confluent lesions in the periventricular and juxta-cortical lesions that fulfil 2017 McDonald criteria for dissemination in space...
April 21, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29660784/relationship-between-neural-crest-cell-specification-and-rare-ocular-diseases
#8
REVIEW
Monica Akula, Jeong Won Park, Judith A West-Mays
Development of the eye is closely associated with neural crest cell migration and specification. Eye development is extremely complex, as it requires the working of a combination of local factors, receptors, inductors, and signaling interactions between tissues such as the optic cup and periocular mesenchyme (POM). The POM is comprised of neural crest-derived mesenchymal progenitor cells that give rise to numerous important ocular structures including those tissues that form the optic cup and anterior segment of the eye...
April 16, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29560120/system-analysis-of-the-regulation-of-the-immune-response-by-cd147-and-foxc1-in-cancer-cell-lines
#9
Yu-Kui Shang, Can Li, Ze-Kun Liu, Ling-Min Kong, Ding Wei, Jing Xu, Zi-Ling Wang, Huijie Bian, Zhi-Nan Chen
CD147, encoded by BSG , is a highly glycosylated transmembrane protein that belongs to the immunological superfamily and expressed on the surface of many types of cancer cells. While CD147 is best known as a potent inducer of extracellular matrix metalloproteinases, it can also function as a key mediator of inflammatory and immune responses. To systematically elucidate the function of CD147 in cancer cells, we performed an analysis of genome-wide profiling across the Cancer Cell Line Encyclopedia (CCLE). We showed that CD147 mRNA expression was much higher than that of most other genes in cancer cell lines...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29552326/research-progress-on-the-forkhead-box-c1
#10
REVIEW
Jinhua Wang, Wan Li, Xiangjin Zheng, Xiaocong Pang, Guanhua Du
FOXC1 is a vital member of FOX families which play important roles in biological processes including proliferation, differentiation, apoptosis, migration, invasion, metabolism, and longevity. Here we are focusing on roles of FOXC1 and their mechanisms in cancers. FOXC1 promoted progress of many cancers, such as breast cancer (especially basal-like breast cancer), hepatocellular carcinoma, gastric cancer and so on. FOXC1 was also found to be associated with drug resistance of cancers. FOXC1 promoted metastasis of cancers by increasing expression of MMP7, NEDD9 and Snail...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29511313/evaluation-of-foxc1-as-a-therapeutic-target-for-basal-like-breast-cancer
#11
Landon Mott, Kai Su, Daniel W Pack
Basal-like breast cancer (BLBC) is a malignant carcinoma with aggressive motility and rapid growth. Accounting for 15% of breast cancers, BLBC often exhibits a poor prognosis and tends to metastasize to the brain and lungs. Because most BLBC display a triple-negative phenotype (ER-, PR-, and HER2-), conventional cytotoxic chemotherapy remains the only treatment option despite poor success and high rate of relapse. The overexpression of the forkhead-box transcription factor C1 (FOXC1) was recently identified as a biomarker of BLBC...
March 6, 2018: Cancer Gene Therapy
https://www.readbyqxmd.com/read/29487724/foxc1-the-new-player-in-the-cancer-sandbox
#12
REVIEW
Fahed A Elian, Elizabeth Yan, Michael A Walter
In recent years, rapidly accumulating evidence implicates forkhead box C1 ( FOXC1 ) in cancer, especially in studies of basal-like breast cancer (BLBC). Other studies have followed suit, demonstrating that FOXC1 is not only a major player in this breast cancer subtype, but also in hepatocellular carcinoma (HCC), endometrial cancer, Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). The FOXC1 gene encodes a transcription factor that is crucial to mesodermal, neural crest, and ocular development, and mutations found in FOXC1 have been found to cause dominantly inherited Axenfeld-Rieger Syndrome (ARS)...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29449899/foxc1-in-cancer-development-and-therapy-deciphering-its-emerging-and-divergent-roles
#13
REVIEW
Zhi Yang, Shuai Jiang, Yicheng Cheng, Tian Li, Wei Hu, Zhiqiang Ma, Fulin Chen, Yang Yang
Forkhead box C1 (FOXC1) is an essential member of the forkhead box transcription factors and has been highlighted as an important transcriptional regulator of crucial proteins associated with a wide variety of carcinomas. FOXC1 regulates tumor-associated genes and is regulated by multiple pathways that control its mRNA expression and protein activity. Aberrant FOXC1 expression is involved in diverse tumorigenic processes, such as abnormal cell proliferation, cancer stem cell maintenance, cancer migration, and angiogenesis...
December 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29328384/forkhead-box-protein-c1-promotes-cell-proliferation-and-invasion-in-human-cervical-cancer
#14
Lu Wang, Lulu Chai, Qingchun Ji, Rongjie Cheng, Jiao Wang, Shiyu Han
Increasing evidence has demonstrated that aberrant forkhead box protein C1 (FOXC1) expression contributes to tumorigenesis in multiple types of malignant tumor. However, the clinical significance and biological roles of FOXC1 in cervical cancer remain unknown. The expression levels of FOXC1 were examined in human cervical cancer tissues and cells using reverse transcription‑quantitative polymerase chain reaction, immunohistochemistry and western blotting. Furthermore, high FOXC1 expression was significantly associated with advanced clinical stages, a high degree of malignancy and a poor outcome...
March 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29322554/transcription-factor-foxc1-is-involved-in-anterior-part-of-cranial-base-formation
#15
Nandar Mya, Toshiko Furutera, Shigeru Okuhara, Tsutomu Kume, Masaki Takechi, Sachiko Iseki
The cranial base is a structure mainly formed through endochondral ossification and integrated into the craniofacial complex, which acts as an underlying platform for the developing brain. Foxc1 is an indispensable regulator during intramembranous and endochondral ossification. In this study, we found that the spontaneous loss of Foxc1 function in a mouse (congenital hydrocephalous), Foxc1ch/ch , demonstrated the anterior cranial base defects, including unossified presphenoid and lack of middle part of the basisphenoid bone...
January 11, 2018: Congenital Anomalies
https://www.readbyqxmd.com/read/29260433/coordinated-targeting-of-mmp-2-mmp-9-by-mir-296-3p-foxcut-exerts-tumor-suppressing-effects-in-choroidal-malignant-melanoma
#16
Xinhe Wang, Yuedong Hu, Jianyi Cui, Yun Zhou, Lei Chen
Choroidal melanoma is the most common intraocular tumor in adults, and overexpression of matrix metalloproteinase-2 or matrix metalloproteinase-9 (MMP-2/MMP-9) is associated with angiogenesis and tumor metastasis of the choroidal malignant melanoma (CMM). This study aims to investigate the functions and mechanisms of microRNA or long non-coding RNA-targeted MMP-2/MMP-9 in CMM. We demonstrated that expressions of MMP-2/MMP-9 were increased in CMM tissues and C918 cells in comparison with normal choroidal melanocytes...
December 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29249801/foxc1-induced-non-canonical-wnt5a-mmp7-signaling-regulates-invasiveness-in-triple-negative-breast-cancer
#17
Bingchen Han, Bo Zhou, Ying Qu, Bowen Gao, Yali Xu, Stacey Chung, Hisashi Tanaka, Wei Yang, Armando E Giuliano, Xiaojiang Cui
Triple-negative breast cancer (TNBC) has high rates of local recurrence and distant metastasis, partially due to its high invasiveness. The Forkhead box C1 (FOXC1) transcription factor has been shown to be specifically overexpressed in TNBC and associated with poor clinical outcome. How TNBC's high invasiveness is driven by FOXC1 and its downstream targets remains poorly understood. In the present study, pathway-specific PCR array assays revealed that WNT5A and matrix metalloproteinase-7 (MMP7) were upregulated by FOXC1 in TNBC cells...
March 2018: Oncogene
https://www.readbyqxmd.com/read/29239730/directed-differentiation-of-periocular-mesenchyme-from-human-embryonic-stem-cells
#18
Matthew Lovatt, Gary Hin-Fai Yam, Gary S Peh, Alan Colman, N Ray Dunn, Jodhbir S Mehta
Corneal tissue is the most transplanted of all body tissues. Currently, cadaveric donor tissues are used for transplantation. However, a global shortage of transplant grade material has prompted development of alternative, cell-based therapies for corneal diseases. Pluripotent stem cells are attractive sources of cells for regenerative medicine, because large numbers of therapeutically useful cells can be generated. However, a detailed understanding of how to differentiate clinically relevant cell types from stem cells is fundamentally required...
January 2018: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29202800/genistein-induces-apoptosis-of-colon-cancer-cells-by-reversal-of-epithelial-to-mesenchymal-via-a-notch1-nf-%C3%AE%C2%BAb-slug-e-cadherin-pathway
#19
Panpan Zhou, Chunling Wang, Zebin Hu, Wenruo Chen, Wentao Qi, Aike Li
BACKGROUND: Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. METHODS: To investigate the effects and mechanisms of genistein on EMT of colon cancer cells, HT-29 cells were used and treated by genistein and TNF-α in this paper. EMT was determined by cell invasion assays using a transwell chamber and the expression changes of EMT-related markers were confirmed by RT-PCR, Western blotting, and immunofluorescence staining...
December 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29162723/the-transcription-factor-foxc1a-in-zebrafish-directly-regulates-expression-of-nkx2-5-encoding-a-transcriptional-regulator-of-cardiac-progenitor-cells
#20
Yunyun Yue, Mingyang Jiang, Luqingqing He, Zhaojunjie Zhang, Qinxin Zhang, Chun Gu, Meijing Liu, Nan Li, Qingshun Zhao
Cardiogenesis is a tightly controlled biological process required for formation of a functional heart. The transcription factor Foxc1 not only plays a crucial role in outflow tract development in mice, but is also involved in cardiac structure formation and normal function in humans. However, the molecular mechanisms by which Foxc1 controls cardiac development remain poorly understood. Previously, we reported that zebrafish embryos deficient in foxc1a , an ortholog of mammalian Foxc1 , display pericardial edemas and die 9-10 days postfertilization...
January 12, 2018: Journal of Biological Chemistry
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