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https://www.readbyqxmd.com/read/28212983/acircularity-index-and-axis-ratio-of-the-foveal-avascular-zone-in-diabetic-eyes-and-healthy-controls-measured-by-optical-coherence-tomography-angiography
#1
Brian D Krawitz, Shelley Mo, Lawrence S Geyman, Steven A Agemy, Nicole K Scripsema, Patricia M Garcia, Toco Y P Chui, Richard B Rosen
Given the complexity of the current system used to stage diabetic retinopathy (DR) and the risks and limitations associated with intravenous fluorescein angiography (IVFA), noninvasive quantification of DR severity is desirable. We examined the utility of acircularity index and axis ratio of the foveal avascular zone (FAZ), metrics that can noninvasively quantify the severity of diabetic retinopathy without the need for axial length to correct for individual retinal magnification. A retrospective review was performed of type 2 diabetics and age-matched controls imaged with optical coherence tomography angiography (OCTA)...
February 14, 2017: Vision Research
https://www.readbyqxmd.com/read/28212878/evaluation-of-macular-vascular-abnormalities-identified-by-optical-coherence-tomography-angiography-in-sickle-cell-disease
#2
Ian C Han, Mongkol Tadarati, Katia D Pacheco, Adrienne W Scott
PURPOSE: To evaluate macular vascular flow abnormalities identified by optical coherence tomography angiography (OCT-A) in patients with various sickle cell genotypes. DESIGN: Prospective, observational case series. METHODS: This is a single institution case series of adult patients with various sickle cell genotypes. All patients underwent macular OCT-A (Avanti RTVue XR, Optovue Inc, Fremont, CA). Images were analyzed qualitatively for areas of flow loss and quantitatively for measures of foveal avascular area, parafoveal flow, and vascular density...
February 14, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28212877/defining-outcomes-for-clinical-trials-of-leber-congenital-amaurosis-caused-by-gucy2d-mutations
#3
Samuel G Jacobson, Artur V Cideciyan, Alexander Sumaroka, Alejandro J Roman, Jason Charng, Monica Lu, Shreyasi Choudhury, Sharon B Schwartz, Elise Heon, Gerald A Fishman, Shannon E Boye
PURPOSE: To determine outcome measures for a clinical trial of Leber congenital amaurosis (LCA) associated with mutations in the GUCY2D gene. DESIGN: Retrospective observational case series. METHODS: 28 patients with GUCY2D-LCA (ages 2-59) were studied clinically and with chromatic full-field sensitivity testing (FST), optical coherence tomography (OCT), pupillometry, and the NEI Visual Function Questionnaire. RESULTS: FST permitted quantitation of cone and rod sensitivity in these patients with severe visual impairment...
February 14, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28209509/the-raptor-visual-system-an-update
#4
J González-Martín-Moro, J L Hernández-Verdejo, A Clement-Corral
OBJECTIVE: Diurnal birds of prey (raptors) are considered the group of animals with highest visual acuity (VA). The purpose of this work is to review all the information recently published about the visual system of this group of animals. MATERIAL AND METHODS: A bibliographic search was performed in PubMed. The algorithm used was (raptor OR falcon OR kestrel OR hawk OR eagle) AND (vision OR «visual acuity» OR eye OR macula OR retina OR fovea OR «nictitating membrane» OR «chromatic vision» OR ultraviolet)...
February 13, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28209502/detailed-phenotyping-and-characterization-of-choroidal-morphological-and-vascular-features-in-young-men-with-high-myopia-using-spectral-domain-optical-coherence-tomography
#5
Preeti Gupta, Sri Gowtham Thakku, Seang-Mei Saw, Mellisa Tan, Edmund Lim, Marcus Tan, Chui Ming Gemmy Cheung, Tien-Yin Wong, Ching-Yu Cheng
PURPOSE: To describe detailed morphological and vascular features of the choroid in eyes with high myopia. DESIGN: Cross-sectional study. METHODS: 515 eyes of young men (mean age 21.59±1.15) years) with high myopia (defined as -6.0 D or worse, mean spherical equivalent -8.66±2.00 D) and 88 controls with emmetropia in both eyes underwent choroidal imaging using spectral domain optical coherence tomography with enhanced depth imaging (EDI-OCT)...
February 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28199005/specialized-photoreceptor-composition-in-the-raptor-fovea
#6
Mindaugas Mitkus, Peter Olsson, Matthew B Toomey, Joseph C Corbo, Almut Kelber
The retinae of many bird species contain a depression with high photoreceptor density known as the fovea. Many species of raptors have two foveae, a deep central fovea and a shallower temporal fovea. Birds have six types of photoreceptors: rods, active in dim light, double cones that are thought to mediate achromatic discrimination, and four types of single cones mediating color vision. To maximize visual acuity, the fovea should only contain photoreceptors contributing to high-resolution vision. Interestingly, it has been suggested that raptors might lack double cones in the fovea...
February 15, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28197754/differences-in-ocular-findings-in-two-siblings-one-with-complete-and-other-with-incomplete-achromatopsia
#7
Shinji Ueno, Ayami Nakanishi, Akira Sayo, Taro Kominami, Yasuki Ito, Takaaki Hayashi, Kazushige Tsunoda, Takeshi Iwata, Hiroko Terasaki
PURPOSE: Patients with complete achromatopsia (ACHM) lack cone function, and patients with incomplete ACHM have relatively good visual acuity with residual color vision. The pathological mechanism(s) underlying incomplete ACHM has not been determined. The purpose of this study was to determine the pathophysiology of ACHM in two siblings: one with complete ACHM and the other with incomplete ACHM. METHODS: The medical charts of the two siblings were reviewed. RESULTS: The sibling with incomplete ACHM had decimal visual acuities that ranged from 0...
February 14, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28196733/the-proportion-of-individuals-likely-to-benefit-from-customized-optic-nerve-head-structure-function-mapping
#8
Allison M McKendrick, Jonathan Denniss, Ya Xing Wang, Jost B Jonas, Andrew Turpin
PURPOSE: Interindividual variance in optic nerve head (ONH) position, axial length, and location of the temporal raphe suggest that customizing mapping between visual field locations and ONH sectors for individuals may be clinically useful. Herein we quantify the proportion of the population predicted to have structure-function mappings that markedly deviate from "average," and thus would benefit from customized mapping. DESIGN: Database study and case report. PARTICIPANTS: Population database of 2836 eyes from the Beijing Eye Study and a single case report of an individual with primary open-angle glaucoma...
February 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28196061/therapeutic-outcomes-after-endoresection-of-complex-retinal-capillary-hemangioblastoma
#9
Murat Karacorlu, Mumin Hocaoglu, Isil Sayman Muslubas, Mehmet Giray Ersoz, Serra Arf
PURPOSE: To evaluate the anatomical and functional outcomes after endoresection of complex retinal capillary hemangioblastoma (RCH). METHODS: Retrospective case series of 12 patients (13 eyes), all treated with pars plana vitrectomy, endodiathermy of feeding and draining vessels, endoresection of RCH and silicone oil injection. RESULTS: The mean age at the time of surgery was 32.5 ± 15.9 years. The mean follow-up duration after initial surgery was 50...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28196052/association-between-tangential-contraction-and-early-vision-loss-in-idiopathic-epiretinal-membrane
#10
Seung Min Lee, Kang Yeun Pak, Han Jo Kwon, Sung Who Park, Ji Eun Lee, Ik Soo Byon
PURPOSE: To investigate the clinical features associated with early visual loss in patients with idiopathic epiretinal membrane. METHODS: Patients with idiopathic epiretinal membrane with visual acuity of ≥20/40, intact ellipsoid zone, and follow-up duration of at least 24 months were included in this retrospective age-matched control study. The disk-fovea-vascular (DFV) distance, central macular thickness, membrane configuration, and ellipsoid zone were assessed using fundus photography and spectral domain optical coherence tomography...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28195612/relationships-between-spatial-contrast-sensitivity-and-parafoveal-cone-density-in-normal-subjects-and-patients-with-retinal-degeneration
#11
Masakazu Hirota, Takeshi Morimoto, Hiroyuki Kanda, Tibor Karl Lohmann, Suguru Miyagawa, Takao Endo, Tomomitsu Miyoshi, Takashi Fujikado
BACKGROUND AND OBJECTIVE: To investigate the relationship between spatial contrast sensitivity (CS) and parafoveal cone density (PCD). PATIENTS AND METHODS: Fifteen healthy individuals (mean age: 26.1 years ± 4.5 years) and nine patients with hereditary retinal degeneration (mean age: 31.6 years ± 13.4 years) without media opacities were studied. The CS was measured by CSV-1000 (VectorVision, Greenville, OH). The cone mosaic was photographed with an adaptive optics scanning laser ophthalmoscope (AOSLO) with a 1° × 1° field of view centered on the fovea...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28192795/wide-field-en-face-swept-source-optical-coherence-tomography-features-of-extrafoveal-retinoschisis-in-highly-myopic-eyes
#12
Wei Xiao, Zhuoting Zhu, Capucine Odouard, Ou Xiao, Xinxing Guo, Mingguang He
Purpose: To evaluate the features of extrafoveal retinoschisis (EFRS) in highly myopic eyes detected by swept-source optical coherence tomography (SS-OCT). Methods: In this retrospective case series, 89 eyes of 65 patients with high myopia and coexisting EFRS were included. The participants underwent a comprehensive ophthalmologic examination, including visual acuity, ocular biometry, refraction, and perimetry. Three-dimensional wide-field scans were obtained with SS-OCT, and en face images were reconstructed with custom software...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28192092/peripheral-oculomotor-training-in-individuals-with-healthy-visual-systems-effects-of-training-and-training-transfer
#13
Dylan Rose, Peter Bex
Individuals with pathological or simulated central visual field loss can be trained to use a preferred retinal locus (PRL) as a substitute for their non-functioning fovea. The functional benefits of a stable PRL are well documented, but little is known about oculomotor adaptations during PRL acquisition or transfer of training to another location in response to real or simulated disease progression. In this study, eight normally-sighted observers were trained to use a pseudo-PRL (pPRL) at one of two locations by guiding an eccentrically placed, gaze-contingent ring over a fixation target...
February 9, 2017: Vision Research
https://www.readbyqxmd.com/read/28191358/retinitis-pigmentosa-and-bilateral-idiopathic-demyelinating-optic-neuritis-in-a-6-year-old-boy-with-ofd1-gene-mutation
#14
Xun Wang, Cong Zheng, Wen Liu, Hui Yang
To identify the cause of a sudden binocular vision decrease in patients with retinitis pigmentosa and bilateral idiopathic demyelinating optic neuritis is difficult, but early diagnosis and treatment significantly improve the prognosis. Here, we report a 6-year-old boy with a progressive binocular vision decrease in 38 days. The patient had a history of night blindness, a mottled retina without pigmentation, extinguished electroretinographic response, tritanopia, and an absent ellipsoid zone outside the macula fovea by optical coherence tomography in both eyes...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28186181/detailed-vascular-anatomy-of-the-human-retina-by-projection-resolved-optical-coherence-tomography-angiography
#15
J P Campbell, M Zhang, T S Hwang, S T Bailey, D J Wilson, Y Jia, D Huang
Optical coherence tomography angiography (OCTA) is a noninvasive method of 3D imaging of the retinal and choroidal circulations. However, vascular depth discrimination is limited by superficial vessels projecting flow signal artifact onto deeper layers. The projection-resolved (PR) OCTA algorithm improves depth resolution by removing projection artifact while retaining in-situ flow signal from real blood vessels in deeper layers. This novel technology allowed us to study the normal retinal vasculature in vivo with better depth resolution than previously possible...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28169876/association-of-drusen-volume-with-choroidal-parameters-in-nonneovascular-age-related-macular-degeneration
#16
Siva Balasubramanian, Jianqin Lei, Muneeswar G Nittala, Swetha B Velaga, Jonathan Haines, Margaret A Pericak-Vance, Dwight Stambolian, SriniVas R Sadda
PURPOSE: The choroid is thought to be relevant to the pathogenesis of nonneovascular age-related macular degeneration, but its role has not yet been fully defined. In this study, we evaluate the relationship between the extent of macular drusen and specific choroidal parameters, including thickness and intensity. METHODS: Spectral domain optical coherence tomography images were collected from two distinct, independent cohorts with nonneovascular age-related macular degeneration: Amish (53 eyes of 34 subjects) and non-Amish (40 eyes from 26 subjects)...
February 6, 2017: Retina
https://www.readbyqxmd.com/read/28169283/ultra-high-resolution-profiles-of-macular-intra-retinal-layer-thicknesses-and-associations-with-visual-field-defects-in-primary-open-angle-glaucoma
#17
Qi Chen, Shenghai Huang, Qingkai Ma, Huiling Lin, Mengmeng Pan, Xinting Liu, Fan Lu, Meixiao Shen
The structural characteristics of the outer retinal layers in primary open angle glaucoma (POAG) are still controversial, and these changes, along with those in the inner retinal layers, could have clinical and/or pathophysiological significance. A custom-built ultra-high resolution optical coherence tomography (UHR-OCT) combined with an automated segmentation algorithm can image and measure the eight intra-retinal layers. The purpose of this study is to determine the thickness characteristics of the macular intra-retinal layers, especially the outer layers, in POAG patients...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28162198/-a-preliminary-study-on-macular-retinal-and-choroidal-thickness-and-blood-flow-change-after-posterior-scleral-reinforcement-by-optical-coherence-tomography-angiography
#18
X F Zhang, L Y Qiao, X X Li, N Ma, M Li, Z Guan, H Z Wang, N L Wang
Objective: To investigate macular retinal and choroidal thickness and blood flow change using optical coherence tomography angiography after posterior scleral reinforcement (PSR) surgery. Methods: Prospective study. Twenty eyes of 10 patients with high myopia were enrolled in this open-label, single-treatment group and prospective study. Radial lines and Angio retina (3 mm×3 mm) module were performed for 20 eyes using Angio-vue optical coherence tomography (Avanti, Optovue) without pupil dilation, and best corrected visual acuity, spherical equivalent and axial length were compared before and 60 days after surgery...
January 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28159970/the-clinical-phenotype-of-cnga3-related-achromatopsia-pretreatment-characterization-in-preparation-of-a-gene-replacement-therapy-trial
#19
Ditta Zobor, Annette Werner, Franco Stanzial, Francesco Benedicenti, Günther Rudolph, Ulrich Kellner, Christian Hamel, Sten Andréasson, Gergely Zobor, Torsten Strasser, Bernd Wissinger, Susanne Kohl, Eberhart Zrenner
Purpose: The purpose of this study was to clinically characterize patients with CNGA3-linked achromatopsia (CNGA3-ACHM) in preparation of a gene therapy trial. Methods: Thirty-six patients (age 7-56 years) with complete (cACHM) or incomplete (iACHM) CNGA3-ACHM were examined, including detailed psychophysical tests, extended electrophysiology, and assessment of morphology by fundus autofluorescence and spectral-domain optical coherence tomography (SD-OCT). Results: Mean best-corrected visual acuity was 0...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28145972/detailed-characterization-of-choroidal-morphologic-and-vascular-features-in-age-related-macular-degeneration-and-polypoidal-choroidal-vasculopathy
#20
Preeti Gupta, Daniel Shu Wei Ting, Sri Gowtham Thakku, Tien-Yin Wong, Ching-Yu Cheng, Edmund Wong, Ranjana Mathur, Doric Wong, Ian Yeo, Chui Ming Gemmy Cheung
PURPOSE: To characterize and compare morphologic and vascular features of the choroid in patients with typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) and to determine if PCV subtypes can be identified based on these choroidal features. METHODS: Choroidal features of patients with AMD and PCV recruited from the prospectively planned Asian AMD Phenotyping Study were analyzed. Patients underwent choroidal imaging using spectral-domain optical coherence tomography with enhanced depth imaging...
January 31, 2017: Retina
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