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https://www.readbyqxmd.com/read/29348471/three-dimensional-evaluation-of-posterior-pole-and-optic-nerve-head-in-tilted-disc
#1
Yong Chan Kim, Ji-Sun Moon, Hae-Young Lopilly Park, Chan Kee Park
For over a century, tilted disc syndrome (TDS) has been defined vaguely. The lack of consensus of the terminology arises from the lack of understanding of the pathogenesis of this condition. Also, myopic discs with temporal crescents or peripapillary atrophy (PPA) are histologically indistinguishable from TDS. Therefore, we examined the morphological background of the extreme ONH appearances such as the myopic tilted disc and the TDS by analyzing the posterior segment of the eye from a three-dimensional (3D) perspective...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29344064/occult-acute-macular-neuroretinopathy
#2
Michael S Vaphiades, Brendan Grondines
A 19-year-old Caucasian woman developed an upper respiratory infection, took a cold formulation containing 5 mg of phenylephrine, and developed a very rare and unusual form of acute macular neuroretinopathy (AMN) that could not be detected on fundoscopic examination, visual fields, nor electrophysiological testing. Spectral-domain optical coherence tomography (SD-OCT) revealed a lesion limited to the fovea. This case illustrates the value of SD-OCT, in light of otherwise normal testing, in a variant of AMN the authors call "occult AMN"...
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29340651/macular-perfusion-parameters-in-different-angiocube-sizes-does-the-size-matter-in-quantitative-optical-coherence-tomography-angiography
#3
Alessandro Rabiolo, Francesco Gelormini, Alessandro Marchese, Maria Vittoria Cicinelli, Giacinto Triolo, Riccardo Sacconi, Lea Querques, Francesco Bandello, Giuseppe Querques
Purpose: To investigate the macular quantitative parameters interchangeability of three different optical coherence tomography angiography (OCT-A) angiocubes (i.e., 3 × 3, 6 × 6, and 12 × 12 mm) on healthy subjects and patients affected by diabetic retinopathy (DR) and to assess the interrater reliability of such indices across the different scan protocols. Methods: Retrospective study involving 20 eyes of healthy subjects and 20 eyes with DR. All eyes underwent swept-source OCT-A with 3 × 3-, 6 × 6-, and 12 × 12-mm angiocubes centered on the fovea...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29338133/pimasertib-associated-ophthalmological-adverse-events
#4
Elon H C van Dijk, Wim H J Kruit, Martine J Jager, Gregorius P M Luyten, Johannes R Vingerling, Camiel J F Boon
PURPOSE: To analyse ophthalmological adverse events associated with mitogen-activated protein kinase kinase (MEK) inhibition with pimasertib treatment for metastatic cutaneous melanoma (CM). METHODS: In this prospective observational, cohort-based, cross-sectional study, eight patients treated with the MEK inhibitor pimasertib received a complete ophthalmic examination. This included Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, visual field testing, colour vision testing, slit-lamp examination, applanation tonometry, indirect ophthalmoscopy, digital colour fundus photography and optical coherence tomography (OCT)...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338123/choroidal-thickness-and-myopia-in-relation-to-physical-activity-the-champs-eye-study
#5
Kristian Lundberg, Anders Højslet Vestergaard, Nina Jacobsen, Anne Suhr Thykjaer, Rasmus Søgaard Hansen, Ernst Goldschmidt, Tunde Peto, Ulrich Halekoh, Niels Wedderkopp, Jakob Grauslund
PURPOSE: To describe the relationship between choroidal thickness (CT) and myopia in relation to physical activity (PA) in a population-based child cohort. METHODS: In a prospective study of 307 children from the CHAMPS Study Denmark, we used objective data from GT3X accelerometer worn at four periods between 2009 and 2015 to determine the amount and intensity of PA. Intensity was estimated as counts/minutes, and cut-off points were defined at four intensity levels...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29327331/calibration-of-peripheral-perception-of-shape-with-and-without-saccadic-eye-movements
#6
Céline Paeye, Thérèse Collins, Patrick Cavanagh, Arvid Herwig
The cortical representations of a visual object differ radically across saccades. Several studies claim that the visual system adapts the peripheral percept to better match the subsequent foveal view. Recently, Herwig, Weiß, and Schneider (2015, Annals of the New York Academy of Sciences, 1339(1), 97-105) found that the perception of shape demonstrates a saccade-dependent learning effect. Here, we ask whether this learning actually requires saccades. We replicated Herwig et al.'s (2015) study and introduced a fixation condition...
January 11, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29327033/disorganization-of-inner-retina-and-outer-retinal-morphology-in-diabetic-macular-edema
#7
Radha Das, Gareth Spence, Ruth E Hogg, Michael Stevenson, Usha Chakravarthy
Importance: In diabetic macular edema (DME), identification of baseline markers on spectral-domain optical coherence tomography (SD-OCT) and their association with severity of diabetic retinopathy (DR) might aid in disease management and the design of future trials. Objective: To examine associations between DR severity, retinal morphology on SD-OCT, and visual acuity in participants with DME. Design, Setting, and Participants: This cross-sectional observational case series was conducted at a single tertiary care referral center...
January 11, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29326847/corneal-scleral-choroidal-and-foveal-thickness-in-patients-with-rheumatoid-arthritis
#8
Onur Gökmen, Nilüfer Yeşilırmak, Ahmet Akman, Sirel Gür Güngör, Ahmet Eftal Yücel, Hilmi Yeşil, Fatih Yıldız, Adam Sise, Vasilios Diakonis
Objectives: To investigate corneal, scleral, choroidal, and foveal thicknesses in female patients with rheumatoid arthritis (RA) and compare them with healthy subjects. Materials and Methods: This prospective study included consecutive female patients diagnosed with RA and healthy subjects. Corneal, scleral, choroidal, and retinal (foveal) thicknesses were obtained by using optical coherence tomography and a comparison was performed between groups for all outcome measures...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29324592/frequent-subclinical-macular-changes-in-combined-braf-mek-inhibition-with-high-dose-hydroxychloroquine-as-treatment-for-advanced-metastatic-braf-mutant-melanoma-preliminary-results-from-a-phase-i-ii-clinical-treatment-trial
#9
Akosua A Nti, Leona W Serrano, Harpal S Sandhu, Katherine E Uyhazi, Ilaina D Edelstein, Elaine J Zhou, Scott Bowman, Delu Song, Tara C Gangadhar, Lynn M Schuchter, Sheryl Mitnick, Alexander Huang, Charles W Nichols, Ravi K Amaravadi, Benjamin J Kim, Tomas S Aleman
PURPOSE: To assess the potential ocular toxicity of a combined BRAF inhibition (BRAFi) + MEK inhibition (MEKi) + hydroxychloroquine (HCQ) regime used to treat metastatic BRAF mutant melanoma. METHODS: Patients with stage IV metastatic melanoma and BRAF V600E mutations (n = 11, 31-68 years of age) were included. Treatment was with oral dabrafenib, 150 mg bid, trametinib, 2 mg/day, and HCQ, 400 mg to 600 mg bid. An ophthalmic examination, spectral domain optical coherence tomography, near-infrared and short-wavelength fundus autofluorescence, and static perimetry were performed at baseline, 1 month, and q/6 months after treatment...
January 10, 2018: Retina
https://www.readbyqxmd.com/read/29324590/repeatability-of-choroidal-thickness-measurements-assessed-with-swept-source-optical-coherence-tomography-in-healthy-and-diabetic-individuals
#10
Beatriz Abadía, Pilar Calvo, Francisco Bartol-Puyal, Guayente Verdes, Inés Suñén, Antonio Ferreras
PURPOSE: To assess the intrasession repeatability of choroidal thickness measurements obtained using swept-source optical coherence tomography in Type 2 diabetic (T2D) patients and healthy controls. METHODS: This was a single-center, prospective, observational, cross-sectional study with consecutive inclusion of 33 healthy subjects and 43 T2D patients. Subjects underwent three consecutive swept-source optical coherence tomography scans in a single session. After automatic delineation of the choroid, subfoveal choroidal thickness, and thickness at 500-μm intervals up to 2,500 μm nasal and temporal from the fovea were measured using the software caliper by the same operator...
January 10, 2018: Retina
https://www.readbyqxmd.com/read/29323133/the-effect-of-image-position-on-the-independent-components-of-natural-binocular-images
#11
David W Hunter, Paul B Hibbard
Human visual performance degrades substantially as the angular distance from the fovea increases. This decrease in performance is found for both binocular and monocular vision. Although analysis of the statistics of natural images has provided significant insights into human visual processing, little research has focused on the statistical content of binocular images at eccentric angles. We applied Independent Component Analysis to rectangular image patches cut from locations within binocular images corresponding to different degrees of eccentricity...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322292/bilateral-symmetrical-comparison-of-the-proximal-femur-using-3d-ct-models
#12
Filip C Dolatowski, Max J Temmesfeld, Claude Pierre-Jerome, Arne Borthne, Sigurd Erik Hoelsbrekken
PURPOSE: Superimposed three-dimensional (3D)-models obtained from CT-images have been used to evaluate displacement of femoral neck fractures, but this method assumes symmetrical anatomy of normal femurs. The present study aimed to compare the spatial orientation of the left and right proximal femur, thus establishing if 3D models can be used as a reference standard for the evaluation of fracture displacement. METHODS: We generated 3D-CT-models of 20 patients with no skeletal pathology of the proximal femurs...
January 10, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29313291/parafoveal-letter-position-coding-in-reading
#13
Joshua Snell, Daisy Bertrand, Jonathan Grainger
The masked-priming lexical decision task has been the paradigm of choice for investigating how readers code for letter identity and position. Insight into the temporal integration of information between prime and target words has pointed out, among other things, that readers do not code for the absolute position of letters. This conception has spurred various accounts of the word recognition process, but the results at present do not favor one account in particular. Thus, employing a new strategy, the present study moves out of the arena of temporal- and into the arena of spatial information integration...
January 8, 2018: Memory & Cognition
https://www.readbyqxmd.com/read/29313145/evaluation-of-choroidal-thickness-in-children-with-adenoid-hypertrophy
#14
Taliye Cakabay, Selin Üstün Bezgin, Sadık Etka Bayramoglu, Nihat Sayin, Murat Kocyigit
OBJECTIVE: To assess choroidal thickness in children with adenoid hypertrophy versus normal controls using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS: Twenty-six children (left and right eyes, total 52 eyes), which were scheduled to adenoidectomy with severe adenoid hypertrophy and 26 age, sex and body mass index-matched healthy subjects (left and right eyes, total 52 eyes) were included in the study. Choroidal thicknesses (CT) were evaluated using enhanced depth imaging optical coherence tomography...
January 8, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29311565/spontaneous-and-training-induced-cortical-plasticity-in-md-patients-hints-from-lateral-masking
#15
Marcello Maniglia, Vincent Soler, Benoit Cottereau, Yves Trotter
Macular degeneration (MD) affects central vision and represents the leading cause of visual diseases in elderly population worldwide. As a consequence of central vision loss, MD patients develop a preferred retinal locus (PRL), an eccentric fixation point that replaces the fovea. Here, our aim was to determine whether and to what extent spontaneous plasticity takes place in the cortical regions formerly responding to central vision and whether a visual training based on perceptual learning (PL) can boost this plasticity within the PRL area...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311323/suppression-of-frontal-eye-field-neuronal-responses-with-maintained-fixation
#16
Koorosh Mirpour, Zeinab Bolandnazar, James W Bisley
The decision of where to make an eye movement is thought to be driven primarily by responses to stimuli in neurons' receptive fields (RFs) in oculomotor areas, including the frontal eye field (FEF) of prefrontal cortex. It is also thought that a saccade may be generated when the accumulation of this activity in favor of one location or another reaches a threshold. However, in the reading and scene perception fields, it is well known that the properties of the stimulus at the fovea often affect when the eyes leave that stimulus...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29304960/editorial-commentary-arthroscopic-hip-ligamentum-teres-reconstruction-reality-or-mythology
#17
EDITORIAL
Ali S Bajwa, Richard N Villar
The ligamentum teres (LT) is perceived to contribute to hip stability and proprioception. LT incompetence can lead to pain and instability, which may play a role in chondral damage. Hip arthroscopy plays a role in diagnosing and treating LT tears. Reconstruction of the LT is feasible, but careful attention needs to be paid to tunnel positioning, graft material, graft length, and fixation methods. An anatomic femoral tunnel should exit at the fovea capitis on the femoral side, whereas the location for safe placement of the acetabular attachment is thought to be in the posteroinferior part of the cotyloid fossa...
January 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29300381/a-homozygous-founder-missense-variant-in-arylsulfatase-g-abolishes-its-enzymatic-activity-causing-atypical-usher-syndrome-in-humans
#18
Samer Khateb, Björn Kowalewski, Nicola Bedoni, Markus Damme, Netta Pollack, Ann Saada, Alexey Obolensky, Tamar Ben-Yosef, Menachem Gross, Thomas Dierks, Eyal Banin, Carlo Rivolta, Dror Sharon
PurposeWe aimed to identify the cause of disease in patients suffering from a distinctive, atypical form of Usher syndrome.MethodsWhole-exome and genome sequencing were performed in five patients from three families of Yemenite Jewish origin, suffering from distinctive retinal degeneration phenotype and sensorineural hearing loss. Functional analysis of the wild-type and mutant proteins was performed in human fibrosarcoma cells.ResultsWe identified a homozygous founder missense variant, c.133G>T (p.D45Y) in arylsulfatase G (ARSG)...
January 4, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29283128/age-and-myopia-associated-optical-coherence-tomography-of-retina-and-choroid-in-pediatric-eyes
#19
Jyoti Matalia, Neha Sutheekshna Anegondi, Leio Veeboy, Abhijit Sinha Roy
PURPOSE: To evaluate the association between retinal and choroidal thickness and volume along with choroidal vessel volume in children using optical coherence tomography (OCT) images. METHODS: 113 normal eyes of children ranging from 5-17 years of age were imaged with a clinical OCT scanner (Optovue Inc., Fremont, USA). The retina, choroid and choroidal vessels were automatically segmented with algorithms. Parameters evaluated were thickness and volume. Location specific analyses of thickness were also performed at a distance of 2...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29275868/ruthenium-brachytherapy-for-uveal-melanomas-factors-affecting-the-development-of-radiation-complications
#20
Monica M Pagliara, Luca Tagliaferri, Luigi Azario, Jacopo Lenkowicz, Angela Lanza, Rosa Autorino, Carmela G Caputo, Maria A Gambacorta, Vincenzo Valentini, Maria A Blasi
PURPOSE: To investigate how treatment complications are related to dosimetric parameters after ruthenium-106 brachytherapy for uveal melanoma, in a large, clinically homogeneous population. METHODS AND MATERIALS: A retrospective review was performed to evaluate patients affected by small and medium size uveal melanoma, treated with ruthenium-106 brachytherapy from December 2006 to December 2014. We excluded tumors with posterior margin within 1 mm from the edge of the optic disc and foveola...
December 21, 2017: Brachytherapy
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