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https://www.readbyqxmd.com/read/29775563/anolis-carolinensis-as-a-model-to-understand-molecular-and-cellular-basis-of-foveal-development
#1
Naif S Sannan, Xianghong Shan, Kevin Gregory-Evans, Kenro Kusumi, Cheryl Y Gregory-Evans
The fovea is an anatomical specialization of the central retina containing closely packed cone-photoreceptors providing an area of high acuity vision in humans and primates. Despite its key role in the clarity of vision, little is known about the molecular and cellular basis of foveal development, due to the absence of a foveal structure in commonly used laboratory animal models. Of the amniotes the retina in birds of prey and some reptiles do exhibit a typical foveal structure, but they have not been studied in the context of foveal development due to lack of availability of embryonic tissue, lack of captive breeding programs, and limited genomic information...
May 15, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29775089/detection-of-perimacular-red-dots-and-blots-when-screening-for-diabetic-retinopathy-refer-or-not-refer
#2
Anatolie Baltatescu, Elio Striglia, Marina Trento, Aurora Mazzeo, Franco Cavallo, Lorena Charrier, Massimo Porta
PURPOSE: Detection of microaneurysms and/or microhaemorrhages near the fovea when screening for diabetic retinopathy poses a problem because referral to retinal specialists may alarm patients and unnecessarily burden ophthalmologists. METHODS: Six-month prospective study of patients found to have minimal red lesions within one disc diameter of the fovea when screened for diabetic retinopathy. Two 45° digital photographs, one centred on the macula and the other nasal including the optic disc, were taken for each eye...
May 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29772043/foveal-avascular-zone-area-analysis-in-macular-hole-before-and-after-surgery-using-optical-coherence-tomography-angiography
#3
Ferdiriva Hamzah, Ari Shinojima, Hiroyuki Nakashizuka, Akiyo Kawamorita, Hiroyuki Shimada
BACKGROUND AND OBJECTIVE: To analyze the foveal avascular zone (FAZ) area in superficial and deep retinal layers in patients with macular hole (MH) before and after surgery. PATIENTS AND METHODS: The authors studied 14 patients with unilateral MH. They examined a 3 mm × 3 mm area at the fovea before and 6 months after surgery using spectral-domain optical coherence tomography angiography. RESULTS: In eyes affected by MH, the mean preoperative superficial FAZ (0...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29771888/-spontaneous-separation-of-secondary-epiretinal-membrane
#4
A V Bushuev, A N Andreev, S N Svetozarskiy
The article presents a rare clinical case of secondary epiretinal membrane (ERM) in a 67-years-old woman. The patient was diagnosed with ERM in the left eye after loss of vision complaints. One year prior to the visit the patient had underwent 2 sessions of laser photocoagulation for proliferative post-thrombotic retinopathy in the left eye. In the context of relatively high visual functions (decimal visual acuity of 0.7 at the time of the visit), observation strategy was carried out. The follow-up period was 2 years...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29768485/choroidal-thickness-in-normal-indian-subjects-using-swept-source-optical-coherence-tomography
#5
Zeeshan Akhtar, Pukhraj Rishi, Ramasubramanian Srikanth, Ekta Rishi, Muna Bhende, Rajiv Raman
AIM: To determine choroidal thickness in healthy Indian subjects using Swept source optical coherence tomography (SS-OCT). METHODS: In this prospective, observational, cross-sectional study; healthy Indian subjects (n = 230) with no history of ocular and/or systemic disorders were enrolled in the study. Choroidal thickness was measured for 230 eyes using SS-OCT. Subjects were divided into six age groups. Main outcome measures were subfoveal choroidal thickness (SFCT) and macular choroidal thickness (MCT) up to 3 mm at 500-micron interval from the fovea was measured in eight different quadrants...
2018: PloS One
https://www.readbyqxmd.com/read/29760528/lrrtm4-c538y-novel-gene-mutation-is-associated-with-hereditary-macular-degeneration-with-novel-dysfunction-of-on-type-bipolar-cells
#6
Yuichi Kawamura, Akiko Suga, Takuro Fujimaki, Kazutoshi Yoshitake, Kazushige Tsunoda, Akira Murakami, Takeshi Iwata
The macula is a unique structure in higher primates, where cone and rod photoreceptors show highest density in the fovea and the surrounding area, respectively. The hereditary macular dystrophies represent a heterozygous group of rare disorders characterized by central visual loss and atrophy of the macula and surrounding retina. Here we report an atypical absence of ON-type bipolar cell response in a Japanese patient with autosomal dominant macular dystrophy (adMD). To identify a causal genetic mutation for the adMD, we performed whole-exome sequencing (WES) on four affected and four-non affected members of the family for three generations, and identified a novel p...
May 14, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29758035/changes-in-macular-pigment-optical-density-after-membrane-peeling
#7
Mario R Romano, Gilda Cennamo, Piergiacomo Grassi, Federica Sparnelli, Davide Allegrini, Giovanni Cennamo
INTRODUCTION: To highlight the differences in macular pigment optical density (MPOD) between eyes with vitreoretinal interface syndrome and healthy control eyes, to assess the changes in MPOD in eyes treated with macular peeling, to investigate the relationships between MPOD changes and measures of retinal sensitivity such as best corrected visual acuity (BCVA) and microperimetry. METHODS: In this cross-sectional comparative study, 30 eyes affected by idiopathic epiretinal membrane (iERM, 15eyes) or full-thickness macular hole (FTMH, 15eyes) were compared with 60 eyes from 30 healthy age-matched patients...
2018: PloS One
https://www.readbyqxmd.com/read/29750947/glaucoma-specialist-optic-disc-margin-rim-margin-and-rim-width-discordance-in-glaucoma-and-glaucoma-suspect-eyes
#8
Seung Woo Hong, Helen Koenigsman, Ruojin Ren, Hongli Yang, Stuart K Gardiner, Juan Reynaud, Robert M Kinast, Steven L Mansberger, Brad Fortune, Shaban Demirel, Claude F Burgoyne
PURPOSE: To quantify the variability of 5 glaucoma specialists' optic disc margin (DM), rim margin (RM) and rim width (RW) estimates. DESIGN: Inter-Observer Reliability analysis. METHODS: Clinicians viewed stereo-photos from 214 subjects with glaucoma or ocular hypertension and digitally marked the DM and RM. For each photo, the centroid of each clinician's DM was calculated, and an averaged DMcentroid was determined. The axis between the DMcentroid and the fovea was used to establish twelve 30° sectors...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750944/ellipsoid-zone-change-according-to-glaucoma-stage-advancement
#9
Ahnul Ha, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: Retinal photoreceptor ellipsoid zone (EZ) intensity comparison between normal eyes and those with different stages of glaucoma. DESIGN: Retrospective cross-sectional study METHODS: The study included 37 normal, 38 pre-perimetric, 39 mild-to-moderate (visual field [VF] mean deviation [MD]: -7.7±2.0 dB), and 36 severe glaucoma eyes (VF MD: -17.8±3.2 dB). The subjects underwent high-resolution horizontal and vertical-line scans through the fovea by spectral-domain optical coherence tomography [SD-OCT] (Spectralis HRA+OCT; Heidelberg)...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750717/effect-of-latanoprost-on-choroidal-thickness
#10
Nedime Sahinoglu-Keskek, Handan Canan
PURPOSE: To evaluate the changes in choroidal thickness during the use of latanoprost eyedrops which shift fluid to the suprachoroidal space and change choroidal perfusion. METHODS: This prospective study included 34 eyes of 17 bilateral glaucoma or ocular hypertensive patients who had no previous hypotensive therapy. Each patient had both eyes treated with latanoprost. Each patient also underwent a complete ophthalmological examination and optical coherence tomography (OCT) measurement...
May 10, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29747369/-the-relationship-between-optical-coherence-tomography-performance-and-visual-acuity-of-acute-retinal-necrosis
#11
Y Di, J J Ye, D H Li
Objective: To analyze the relationship between optical coherence tomography(OCT) performance and visual acuity of patients with acute retinal necrosis (ARN). Methods: Retrospective analysis was performed on the patients diagnosed with ARN at the ophthalmology department of Peking union hospital during October 2011 and May 2016. Fourteen patients (15 eyes), 9 males and 5 females, whose anterior and posterior inflammation disappeared and the retinal necrosis lesion in the fundus of the eye subsided were included...
May 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29747354/-long-term-clinical-observation-on-postoperative-microstructural-change-of-macula-lutea-in-treatment-of-idiopathic-macular-epiretinal-membrane
#12
M F Jiao, J P Liu, X T Chen, X R Li
Objective: To evaluate the relationship between the structure of macular region and prognosis after vitrectomy in idiopathic macular epiretinal membrane patients. Methods: Retrospective case series study. The cases of 74 idiopathic macular epiretinal membrane patients (31 female patients, 43 male patients, aged 68.1±6.9) who received surgery treatment in our hospital during January 2013 and December were collected and analyzed. Ophthalmic routine examination and optical coherence tomography (OCT) have been conducted for all patients prior to operation...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29746407/swept-source-optical-coherence-tomography-angiography-reveals-internal-limiting-membrane-peeling-alters-deep-retinal-vasculature
#13
Zofia Michalewska, Jerzy Nawrocki
PURPOSE: To describe morphology of retinal and choroidal vessels in swept-source optical coherence tomography angiography before and after vitrectomy with the temporal inverted internal limiting membrane (ILM) flap technique for full-thickness macular holes. METHODS: Prospective, observational study of 36 eyes of 33 patients with full-thickness macular holes swept-source optical coherence tomography angiography was performed in patients before and 1 month after vitrectomy...
April 30, 2018: Retina
https://www.readbyqxmd.com/read/29742514/foveal-depression-and-related-factors-in-patients-with-a-history-of-retinopathy-of-prematurity
#14
Akiko Miki, Shigeru Honda, Yukako Inoue, Yuko Yamada, Makoto Nakamura
PURPOSE: This study evaluates optical coherence tomography (OCT) findings of the macula in patients with a history of retinopathy of prematurity (ROP). METHODS: We enrolled 112 patients (age: 6-15 years) and categorized them into 3 groups: gestational age (GA) < 36 weeks with or without a history of ROP (ROP group, preterm group) and GA ≥37 weeks. We included 1 eye of each patient and measured the retinal thickness of the macula by OCT. RESULTS: The ROP group demonstrated the worst VA and the shallowest foveal depression...
May 9, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29739379/assessment-of-capillary-dropout-in-the-superficial-retinal-capillary-plexus-by-optical-coherence-tomography-angiography-in-the-early-stage-of-diabetic-retinopathy
#15
Ceying Shen, Shu Yan, Min Du, Hong Zhao, Ling Shao, Yibo Hu
BACKGROUND: To assess capillary dropout in the superficial retinal capillary plexus (SCP) by optical coherence tomography angiography (OCTA) in the early stage of diabetic retinopathy (DR). METHODS: This study was a cross-sectional observational study. Patients that underwent OCTA examinations in our hospital between November 2015 and May 2016 were included in the study. The subjects were divided into two groups: A) normal controls (41 eyes of 41 subjects) and B) the DR patients (49 eyes of 49 patients with mild non-proliferative DR (NPDR))...
May 8, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29730055/funduscopic-examination-and-sd-oct-in-detecting-sickle-cell-retinopathy-among-pediatric-patients
#16
Jing Jin, Robin Miller, Jonathan Salvin, Sharon Lehman, Dorothy Hendricks, Amanda Friess, Lauren Libfraind
PURPOSE: To compare the results of fundus examination and spectral domain optic coherence tomography (SD-OCT) in detecting retinal changes in pediatric patients with sickle cell disease at a single center. METHODS: In this prospective study, conducted over a period of 19 months, consecutive African American patients with sickle cell disease underwent complete ophthalmologic examination, and SD-OCT images of the maculas of both eyes were obtained. RESULTS: A total of 69 (37 males) patients aged 5-20 years (mean 12...
May 3, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29728242/macula-segmentation-and-fovea-localization-employing-image-processing-and-heuristic-based-clustering-for-automated-retinal-screening
#17
GeethaRamani R, Lakshmi Balasubramanian
BACKGROUND AND OBJECTIVE: Macula segmentation and fovea localization is one of the primary tasks in retinal analysis as they are responsible for detailed vision. Existing approaches required segmentation of retinal structures viz. optic disc and blood vessels for this purpose. METHOD: This work avoids knowledge of other retinal structures and attempts data mining techniques to segment macula. Unsupervised clustering algorithm is exploited for this purpose. Selection of initial cluster centres has a great impact on performance of clustering algorithms...
July 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29719642/oct-based-macular-thickness-in-a-normal-indian-pediatric-population
#18
Bharti Nigam, Pragati Garg, Lubna Ahmad, Ritika Mullick
Purpose: Cirrus optical coherence tomography (OCT) provides high resolution cross-sectional images of the retina, vitreous humor, and optic nerve head with an axial resolution of 5 μm and a reproducibility of 1.6 μm. An integrated normative database is available only for adult subjects ≥18 years of age; the normal reference ranges of the macular thicknesses of pediatric subjects are not available. The purpose of this study was to determine the normal reference range of macular thickness of pediatric...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29718797/cep250-mutations-associated-with-mild-cone-rod-dystrophy-and-sensorineural-hearing-loss-in-a-japanese-family
#19
Daiki Kubota, Kiyoko Gocho, Sachiko Kikuchi, Keiichiro Akeo, Masahiro Miura, Kunihiko Yamaki, Hiroshi Takahashi, Shuhei Kameya
BACKGROUND: CEP250 encodes the C-Nap1 protein which belongs to the CEP family of proteins. C-Nap1 has been reported to be expressed in the photoreceptor cilia and is known to interact with other ciliary proteins. Mutations of CEP250 cause atypical Usher syndrome which is characterized by early-onset sensorineural hearing loss (SNHL) and a relatively mild retinitis pigmentosa. This study tested the hypothesis that the mild cone-rod dystrophy (CRD) and SNHL in a non-consanguineous Japanese family was caused by CEP250 mutations...
May 2, 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29712637/efficacy-of-non-fovea-sparing-ilm-peeling-for-symptomatic-myopic-foveoschisis-with-and-without-macular-hole
#20
Amer Hamad Al-Badawi, Mohamad Amr Salah Eddin Abdelhakim, Tamer Ahmed Macky, Hassan Aly Mortada
AIM: To study anatomical and visual outcomes of pars plana vitrectomy (PPV) with non-fovea-sparing (entire) internal limiting membrane (ILM) peeling in eyes with myopic foveoschisis (MF). METHODS: Prospective interventional case series of eyes undergoing PPV with entire ILM peeling for symptomatic MF. MAIN OUTCOME MEASURES: Preoperative spectral domain optical coherence tomography (SD - OCT) epiretinal membrane, anomalous posterior vitreous detachment, vitreoschisis and postoperative changes in SD-OCT central foveal thickness (CFT), ellipsoid zone defect, foveal detachment (FD), macular hole (MH) diameter (if present) and best-corrected visual acuity (BCVA) in logarithm of the minimum angle of resolution (logMAR)...
April 30, 2018: British Journal of Ophthalmology
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