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https://www.readbyqxmd.com/read/28433753/computational-image-analysis-for-prognosis-determination-in-dme
#1
Bianca S Gerendas, Hrvoje Bogunovic, Amir Sadeghipour, Thomas Schlegl, Georg Langs, Sebastian M Waldstein, Ursula Schmidt-Erfurth
In this pilot study, we evaluated the potential of computational image analysis of optical coherence tomography (OCT) data to determine the prognosis of patients with diabetic macular edema (DME). Spectral-domain OCT scans with fully automated retinal layer segmentation and segmentation of intraretinal cystoid fluid (IRC) and subretinal fluid of 629 patients receiving anti-vascular endothelial growth factor therapy for DME in a randomized prospective clinical trial were analyzed. The results were used to define 312 potentially predictive features at three timepoints (baseline, weeks 12 and 24) for best-corrected visual acuity (BCVA) at baseline and after one year used in a random forest prediction path...
April 19, 2017: Vision Research
https://www.readbyqxmd.com/read/28426626/parapapillary-gamma-and-delta-zones-in-high-myopia
#2
Jost B Jonas, Yuxin Fang, Pascal Weber, Kyoko Ohno-Matsui
PURPOSE: To examine parapapillary zones gamma and delta in highly myopic eyes. METHODS: The retrospective observational study included patients attending the Tokyo high myopia clinics. Fundus photographs were morphometrically examined. RESULTS: The study population included 600 eyes (304 individuals) with a mean age of 62.7 ± 14.3 years (range: 13-90 years) and mean axial length of 29.6 ± 2.2 mm (range: 23.2-35.4 mm). In multivariate analysis (regression coefficient r:0...
April 19, 2017: Retina
https://www.readbyqxmd.com/read/28419396/correlation-between-mesopic-retinal-sensitivity-and-optical-coherence-tomographic-metrics-of-the-outer-retina-in-patients-with-non-atrophic-dry-age-related-macular-degeneration
#3
Tudor C Tepelus, Amir H Hariri, Mayss Al-Sheikh, SriniVas R Sadda
BACKGROUND AND OBJECTIVE: To determine the correlation between mesopic retinal sensitivity and optical coherence tomographic metrics of the outer retina in patients with intermediate age-related macular degeneration (AMD). PATIENTS AND METHODS: Participants with nonatrophic dry AMD underwent mesopic MP-3 microperimetry (Nidek, Padova, Italy) and both Nidek and Cirrus (Carl Zeiss Meditec, Dublin, CA) spectral-domain optical coherence tomography (SD-OCT). The volume of the outer retinal layers was measured on the Nidek SD-OCT scans using the automatic segmentation algorithm of Navis-EX software...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28416492/intravitreal-triamcinolone-acetate-for-radiation-maculopathy-recalcitrant-to-high-dose-intravitreal-bevacizumab
#4
Richard I Kaplan, Sonal S Chaugule, Paul T Finger
BACKGROUND/AIMS: To evaluate the effect of adjuvant intravitreal triamcinolone acetonide (ITA) for radiation maculopathy (RM) recalcitrant to high-dose bevacizumab in patients with choroidal melanoma after plaque radiotherapy. METHODS: Eight eyes of eight patients with RM secondary to plaque radiotherapy for choroidal melanoma, recalcitrant to high-dose bevacizumab (3.0 mg) were retrospectively evaluated. Intravitreal injections of ITA (4 mg/0.1 mL) were performed at 4-week to 16-week intervals as an adjunct to continued bevacizumab therapy...
April 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28404522/observations-on-the-relationship-between-anisometropia-amblyopia-and-strabismus
#5
Earl L Smith, Li-Fang Hung, Baskar Arumugam, Janice M Wensveen, Yuzo M Chino, Ronald S Harwerth
We investigated the potential causal relationships between anisometropia, amblyopia and strabismus, specifically to determine whether either amblyopia or strabismus interfered with emmetropization. We analyzed data from non-human primates that were relevant to the co-existence of anisometropia, amblyopia and strabismus in children. We relied on interocular comparisons of spatial vision and refractive development in animals reared with 1) monocular form deprivation; 2) anisometropia optically imposed by either contact lenses or spectacle lenses; 3) organic amblyopia produced by laser ablation of the fovea; and 4) strabismus that was either optically imposed with prisms or produced by either surgical or pharmacological manipulation of the extraocular muscles...
April 18, 2017: Vision Research
https://www.readbyqxmd.com/read/28403185/correlation-of-choroidal-thickness-and-ametropiain-young-adolescence
#6
Xiaolei Shao, Chang Zou, Bo Qin
Choroid has been proposed to participate in the regulation of light refraction by changing its thickness. The present study aims to analyze the characteristics of choroidal thickness (CT), and its correlation with refractive error, axial length and age in young ametropia. A total of 51 subjects (102 eyes), aged from 5 to 18 years old (mean age 10.04 ±2.78 years), with ametropia were included in the study. Choroidal imaging was obtained by enhanced depth imaging (EDI) of spectral domain Optical Coherence Tomography (OCT)...
2017: PloS One
https://www.readbyqxmd.com/read/28403107/reference-interval-for-the-disc-macula-distance-to-disc-diameter-ratio-in-a-large-population-of-healthy-japanese-adults-a-prospective-observational-study
#7
Ken-Ichi Sato
This study presents the calculated reference interval for the disc-to-macula distance to disc diameter ratio (DM:DD) based on a large population of healthy Japanese adults.A total of 308 consecutive, healthy Japanese adults were examined in this prospective observational study. Eighteen subjects were also excluded because of poor quality of the fundus photograph of one or both eyes; 290 (161 men and 129 women) were included in this study. For each subject, a color fundus photograph of one eye, either the right or left, was randomly selected and used for analysis...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28403037/characteristics-of-submacular-hemorrhages-in-age-related-macular-degeneration
#8
Jae Hui Kim, Young Suk Chang, Jong Woo Kim, Chul Gu Kim
PURPOSE: The aims of this research are to report the incidence and characteristics of submacular hemorrhage secondary to neovascular age-related macular degeneration (AMD) and to compare the detailed morphologic features of hemorrhages between typical neovascular AMD and polypoidal choroidal vasculopathy (PCV). METHODS: This retrospective observational study included 791 eyes of 791 patients who had newly diagnosed neovascular AMD at a single institution. The incidence and extent of submacular hemorrhage of one disc area or greater were estimated and compared between typical neovascular AMD and PCV...
May 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28401372/choroidal-thickness-alterations-in-diabetic-nephropathy-patients-with-early-or-no-diabetic-retinopathy
#9
Can Kocasarac, Yavuz Yigit, Erkan Sengul, Yildirim Beyazit Sakalar
PURPOSE: To assess changes in choroidal thickness (CT) in diabetes patients with and without diabetic nephropathy using enhanced depth imaging spectral domain optical coherence tomography (EDI-OCT). METHODS: Thirty-five type 2 diabetes patients with a diagnosis of diabetic nephropathy (DNP) in nephrology department and 35 type 2 diabetes patients without nephropathy (non-DNP) were included in our prospective study consecutively. The control group comprised 34 healthy individuals...
April 11, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28400888/macular-evaluation-w%C3%A4-th-spectral-domain-type-optic-coherence-tomography-in-eyes-with-acute-nonarteritic-ischemic-optic-neuropathy-at-the-presentation-visit
#10
Oya Donmez, Gamze Kocaoglu, Aylin Yaman, Meltem Soylev Bajin, Ali Osman Saatci
PURPOSE: To evaluate the macula with spectral domain type optic coherence tomography (OCT) in eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION) at the presentation visit. METHODS: Medical charts of the 133 patients who received the diagnosis of acute NAION between January 2008 and July 2014 at the Neuro-ophthalmology unit of Dokuz Eylul University were reviewed retrospectively. Sixtythree patients within 30 days of symptom onset with available baseline spectral domain type macular OCT were included in this study...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28399346/tumors-and-related-lesions-of-the-pigmented-epithelium
#11
Jerry A Shields, Carol L Shields
Several tumors and pseudotumors can arise from the iris pigment epithelium (IPE), ciliary pigment epithelium (CPE), and retinal pigment epithelium (RPE), including cysts of the IPE, solitary congenital hypertrophy of the RPE (CHRPE), multifocal CHRPE ("bear tracks"), congenital simple hamartoma of the RPE, combined hamartoma of the retina and RPE, and acquired epithelioma of IPE, CPE, and RPE. This article describes examples of pigment epithelial tumors and pseudotumors by reviewing the literature and cases on file in the Oncology Service at Wills Eye Hospital...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28396339/poppers-legal-highs-with-questionable-contents-a-case-series-of-poppers-maculopathy
#12
Rebecca Rewbury, Edward Hughes, Robert Purbrick, Stephen Prior, Mark Baron
BACKGROUND: Poppers are volatile alkyl nitrite compounds that are inhaled to enhance sexual experience and for their psychoactive effects. A less well-known side effect is foveal maculopathy, which has emerged following changes in their chemical composition. It is unclear if certain individuals are more susceptible to retinal damage or if there is a relationship between pattern of inhalation and brands used. METHODS: A case series of 12 patients presenting to Sussex Eye Hospital, Brighton, with poppers-related visual impairment...
April 10, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28394809/structure-function-relationship-between-the-bruch-membrane-opening-based-minimum-rim-width-and-visual-field-defects-in-advanced-glaucoma
#13
Serhat Imamoglu, Nimet Burcu Celik, Mehmet S Sevim, Gokhan Pekel, Nimet Yesim Ercalik, Esra Turkseven Kumral, Handan Bardak
PURPOSE: To investigate the relationship between the Bruch membrane opening-minimum rim width (BMO-MRW) (global and temporal) parameters with spectral-domain optical coherence tomography (SD-OCT) and visual field (VF) sensitivity on the 10-2 test in patients with advanced glaucoma. MATERIALS AND METHODS: This cross-sectional, observational study included a total of 33 eyes of 29 patients. To evaluate VF sensitivity, automated white-on-white perimetry was performed using a Humphrey field analyzer...
April 7, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28391446/a-review-of-current-and-future-management-of-geographic-atrophy
#14
REVIEW
Riccardo Sacconi, Eleonora Corbelli, Lea Querques, Francesco Bandello, Giuseppe Querques
Age-related macular degeneration (AMD) is a multifactorial disease and a leading cause of vision impairment in elderly people in Western society. Geographic atrophy (GA), the late stage of dry AMD, is typically defined as a round or oval area of atrophy of 175 µm or more. In GA patients, visual acuity (VA) can still be good if the macula is spared, but decreased if GA extends through the fovea causing a great impairment of quality of life. Because of a poor correlation between VA and GA lesions or progression, a multimodal imaging approach is necessary to better follow up GA patients...
April 8, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28388698/the-magnification-factor-accounts-for-the-greater-hypometria-and-imprecision-of-larger-saccades-evidence-from-a-parametric-human-behavioral-study
#15
Françoise Vitu, Soazig Casteau, Hossein Adeli, Gregory J Zelinsky, Eric Castet
Saccades quite systematically undershoot a peripheral visual target by about 10% of its eccentricity while becoming more variable, mainly in amplitude, as the target becomes more peripheral. This undershoot phenomenon has been interpreted as the strategic adjustment of saccadic gain downstream of the superior colliculus (SC), where saccades are programmed. Here, we investigated whether the eccentricity-related increase in saccades' hypometria and imprecision might not instead result from overrepresentation of space closer to the fovea in the SC and visual-cortical areas...
April 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28384671/acute-zonal-cone-photoreceptor-outer-segment-loss
#16
Tomas S Aleman, Harpal S Sandhu, Leona W Serrano, Anastasia Traband, Marisa K Lau, Grazyna Adamus, Robert A Avery
Importance: The diagnostic path presented narrows down the cause of acute vision loss to the cone photoreceptor outer segment and will refocus the search for the cause of similar currently idiopathic conditions. Objective: To describe the structural and functional associations found in a patient with acute zonal occult photoreceptor loss. Design, Setting, and Participants: A case report of an adolescent boy with acute visual field loss despite a normal fundus examination performed at a university teaching hospital...
April 6, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28375424/dental-nonmetric-trait-intraobserver-precision-three-observations-of-a-large-sample
#17
Luís Miguel Marado
The utility of nonmetric dental traits in population phenetic studies is well documented. However, consistency in scoring trait expression is a concern due to the subjectivity in scoring quasicontinuous variables with graded scales. The aims of this study are to 1) analyze intraobserver results from an independent scorer and 2) interpret the least precise results. Six hundred individuals (300 of each sex) were scored for 48 dental nonmetric traits using ASUDAS, in one preliminary (100 individuals) and two full observations...
April 4, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/28374276/recurrent-focal-choroidal-excavation-following-multiple-evanescent-white-dot-syndrome-mewds-associated-with-acute-idiopathic-blind-spot-enlargement
#18
Mohammad Hossein Jabbarpoor Bonyadi, Kiana Hassanpour, Masoud Soheilian
PURPOSE: To present a recurrent case of conforming focal choroidal excavation (FCE) following multiple evanescent white dot syndrome (MEWDS) in a 25-year-old woman. METHODS: Following spontaneous MEWDS sings resolution our patient noted a recurrent decrease in vision. Repeated OCT revealed elevation and mild disruption of RPE layer at fovea without previous angiographic MEWDS signs. At this time, short-term systemic steroid therapy was started and visual acuity became normal...
April 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28373941/arthroscopically-assisted-transosseous-foveal-repair-of-triangular-fibrocartilage-complex
#19
Wei-Jen Chen
The radioulnar ligament of the triangular fibrocartilage complex (TFCC), especially the deep fibers inserted at the ulnar fovea, is the key component for the distal radioulnar joint (DRUJ) stability. Traumatic injuries to the TFCC foveal insertion would cause DRUJ instability. Traditionally, arthroscopic techniques of the TFCC repair are suturing the ulnar-sided disruption peripherally to the dorsal or ulnar capsule instead of suturing the TFCC to the fovea and thus fail to restore the DRUJ stability if the TFCC is detached from the fovea...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28369662/early-pleistocene-hominin-deciduous-teeth-from-the-homo-antecessor-gran-dolina-td6-bearing-level-sierra-de-atapuerca-spain
#20
José María Bermúdez de Castro, María Martinón-Torres, Laura Martín-Francés, Marina Martínez de Pinillos, Mario Modesto-Mata, Cecilia García-Campos, Xiujie Wu, Song Xing, Wu Liu
OBJECTIVES: During the last 13 years, the late Early Pleistocene Gran Dolina-TD6-2 level (Sierra de Atapuerca, northern Spain) has yielded an additional sample of 26 dental specimens attributed to Homo antecessor. In this report, we present a descriptive and comparative study of the six deciduous teeth. METHODS: We provide external and internal morphological descriptions following classical terminology, as well as the mesiodistal and buccolingual measurements of the teeth...
March 31, 2017: American Journal of Physical Anthropology
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