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https://www.readbyqxmd.com/read/28937859/choroidal-thickness-in-traumatic-optic-neuropathy
#1
Ju-Yeun Lee, Doo-Ri Eo, Kyung-Ah Park, Sei Yeul Oh
PURPOSE: To examine the choroidal thickness in patients with indirect traumatic optic neuropathy (TON) Methods: Patients with unilateral traumatic optic neuropathy over a period of 4 years were included in this study. Horizontal and vertical enhanced-depth imaging (EDI) from spectral-domain optical coherence tomography (SD-OCT) scans of the fovea were obtained in patients with unilateral TON within 2 weeks of injury. The main outcome measure was the choroidal thickness at nine locations...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28934255/quantitative-optical-coherence-tomography-angiography-of-macular-vascular-structure-and-foveal-avascular-zone-in-glaucoma
#2
Jaewan Choi, Junki Kwon, Joong Won Shin, Jiyun Lee, Saem Lee, Michael S Kook
OBJECTIVE: The study aimed to evaluate the quantitative characteristics of the macular vessel density (VD) and foveal avascular zone (FAZ) in glaucoma using optical coherence tomography angiography (OCT-A). DESIGN: Cross-sectional, age- and sex-matched case-control study. METHODS: Fifty-two eyes of 52 patients with primary open angle glaucoma and 52 eyes from 52 healthy participants were recruited retrospectively. OCT-A was performed on a 3 x 3-mm macular region centered on the fovea...
2017: PloS One
https://www.readbyqxmd.com/read/28933041/macular-hole-caused-by-retained-subfoveal-perfluorocarbon-that-subsequently-closed-after-its-spontaneous-resolution-a-case-report
#3
Reiko Tanabu, Yukihiko Suzuki, Kaori Suzuki, Shizuka Takahashi, Mitsuru Nakazawa, Hideyuki Mizutani
INTRODUCTION: To prevent local reduction in retinal function caused by retained subretinal perfluorocarbon liquid (PFCL), it has been noted that removal of PFCL under the fovea should be considered, with a vitrectomy selected for such removal. CASE REPORT: A vitrectomy was performed for traumatic retinal detachment during which PFCL was temporarily used as an intraocular tamponade for retina flattening. Following surgery, subfoveal PFCL was retained beneath the retina...
September 20, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28930613/an-automated-approach-for-early-detection-of-diabetic-retinopathy-using-sd-oct-images
#4
Ahmed H ElTanboly, Agustina Palacio, Ahmed M Shalaby, Andrew E Switala, Omar Helmy, Shlomit Schaal, Ayman El-Baz
  This study was to demonstrate the feasibility of an automatic approach for early detection of diabetic retinopathy (DR) from SD-OCT images. These scans were prospectively collected from 200 subjects through the fovea then were automatically segmented, into 12 layers. Each layer was characterized by its thickness, tortuosity, and normalized reflectivity. 26 diabetic patients, without DR changes visible by funduscopic examination, were matched with 26 controls, according to age and sex, for purposes of statistical analysis using mixed effects ANOVA...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28928374/rethinking-the-origin-of-primates-by-reconstructing-their-diel-activity-patterns-using-genetics-and-morphology
#5
Yonghua Wu, Haifeng Wang, Haitao Wang, Elizabeth A Hadly
Phylogenetic inference typically invokes nocturnality as ancestral in primates; however, some recent studies posit that diurnality is. Here, through adaptive evolutionary analyses of phototransduction genes by using a variety of approaches (restricted branch/branch-site models and unrestricted branch-site-based models (BS-REL, BUSTED and RELAX)), our results consistently showed that ancestral primates were subjected to enhanced positive selection for bright-light vision and relatively weak selection for dim-light vision...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28926210/clinical-relevance-of-retinal-structure-in-children-with-laser-treated-retinopathy-of-prematurity-versus-controls-using-optical-coherence-tomography
#6
Florina Stoica, Adela Chirita-Emandi, Nicoleta Andreescu, Alina Stanciu, Cristian G Zimbru, Maria Puiu
PURPOSE: We aimed to assess the macular anatomy using spectral domain optical coherence tomography (SD-OCT), in children born preterm who had laser-treated retinopathy of prematurity (ROP), and to investigate the relationship between structural changes in macula and visual function. METHODS: Thirty-seven 3-8 years old children were included in the study in two groups: 20 children born preterm [(<34 weeks of gestation, birthweight (BW) <2000 g)] who had laser-treated ROP in the Neonatology Department, Municipal Clinical Emergency Hospital of Timisoara, Romania; and 17 controls (children born at term, without eye disease, matched for age and gender)...
September 19, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28926202/retinal-dysfunction-characterizes-subtypes-of-dominant-optic-atrophy
#7
Maria Lucia Cascavilla, Vincenzo Parisi, Giacinto Triolo, Lucia Ziccardi, Enrico Borrelli, Antonio Di Renzo, Nicole Balducci, Costanza Lamperti, Stefania Bianchi Marzoli, Fatima Darvizeh, Alfredo A Sadun, Valerio Carelli, Francesco Bandello, Piero Barboni
PURPOSE: To assess preganglionic retinal function using multifocal electroretinogram (mfERG) in patients affected by dominant optic atrophy (DOA) stratified by OPA1 gene mutation. METHODS: Multifocal electroretinogram (mfERG) was recorded in 18 DOA patients (DOA group, 35 eyes) and 25 age-matched healthy subjects (control group, 25 eyes). Patients were stratified in two groups based on gene mutation: missense mutation (DOA-M group, 11 eyes) and mutation causing haploinsufficiency (DOA-H group, 24 eyes)...
September 19, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28923585/the-genetics-of-congenital-aniridia-a-guide-for-the-ophthalmologist
#8
Erlend S Landsend, Øygunn A Utheim, Hilde R Pedersen, Neil Lagali, Rigmor C Baraas, Tor P Utheim
Congenital aniridia is a rare panocular disease caused by fundamental disturbances in the development of the eye, characterized primarily by hypoplasia of the iris and the retinal fovea. Severe secondary complications such as keratopathy, cataract, and glaucoma are common and often lead to considerable visual impairment or blindness. Many complications in aniridia patients are difficult to treat and present a challenge for the ophthalmologist. Increasingly, associated non-ocular features of the disease are also being recognised...
September 15, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28915835/macular-retinal-and-choroidal-thickness-in-unilateral-amblyopia-using-swept-source-optical-coherence-tomography
#9
Syunsuke Araki, Atsushi Miki, Katsutoshi Goto, Tsutomu Yamashita, Go Takizawa, Kazuko Haruishi, Yoshiaki Ieki, Junichi Kiryu, Kiyoshi Yaoeda
BACKGROUND: To investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT). METHODS: This study examined 31 patients with hyperopic anisometropic amblyopia (6.9 ± 3.8 years, mean ± standard deviation), 15 patients with strabismic amblyopia without anisometropia (7.9 ± 4.2 years), and 24 age-matched controls (7.8 ± 3.3 years). Retinal and choroidal thickness was measured by 3D scans using SS-OCT...
September 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28912516/choroidal-thickness-measurements-in-children-with-isolated-growth-hormone-deficiency
#10
N G Yalcin, Z Aktas, O Yuce, G D G Ikiz, M Hasanreisoglu, A Bideci
PurposeThe aim of this study was to determine the choroidal thickness measurement values in cases with isolated growth hormone deficiency (IGHD), to compare them with the healthy control group by using enhanced depth imaging optical coherence tomography (EDI-OCT), and to evaluate the effect of growth hormone (GH) treatment on choroid.Patients and methodsIn this study, 23 cases who were diagnosed with IGHD as a study group and 46 healthy subjects as a control group were included. All patients and controls underwent a complete ophthalmologic examination, including an examination with EDI-OCT...
September 15, 2017: Eye
https://www.readbyqxmd.com/read/28904217/two-orthoptic-treatments-in-dragged-fovea-diplopia-syndrome
#11
Silvia Maddii, Ilaria Biagini, Alessia Aragno, Mario Scrivanti, Barbara Giambene, Stanislao Rizzo, Gianni Virgili
BACKGROUND: "Dragged-fovea diplopia syndrome" is a type of central binocular diplopia that is secondary to a foveal displacement, caused by epiretinal membranes (ERMs) or other macular diseases. Its management is difficult, because prisms are not effective. CASE REPORTS: Two cases of dragged-fovea diplopia syndrome were presented. Both patients were affected with a unilateral epiretinal membrane. Therefore, the pathophysiology underlying their diplopia was the conflict between central and peripheral fusion mechanisms...
January 2017: American Orthoptic Journal
https://www.readbyqxmd.com/read/28890078/choroidal-thinning-associated-with-hydroxychloroquine-retinopathy
#12
Seong Joon Ahn, So Jung Ryu, Joo Young Joung, Byung Ro Lee
PURPOSE: To investigate choroidal thickness in patients using hydroxychloroquine (HCQ) and compare choroidal thickness between eyes with and without HCQ retinopathy. DESIGN: Retrospective case series METHODS: Setting: Institutional Patients: We included 124 patients with systemic lupus erythematosus or rheumatoid arthritis who were treated with HCQ. The patients were divided into an HCQ retinopathy group and a control group, according to the presence or absence of HCQ retinopathy...
September 7, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28885671/the-effect-of-strabismus-surgery-on-choroidal-thickness
#13
Kamil Inan, Leyla Niyaz
PURPOSE: To determine the effects of strabismus surgery on choroidal thickness. METHODS: This was a prospective randomized study. The measurements of subfoveal and macular choroidal thickness of patients who underwent strabismus surgery were obtained by enhanced depth imaging optic coherence tomography. The patients were grouped as patients who had 1 horizontal muscle surgery (group 1), 1 oblique muscle surgery (group 2), 2 horizontal muscle surgeries (group 3), or 1 horizontal and 1 oblique muscle surgery (group 4)...
September 7, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28884436/effects-of-vegf-levels-on-anti-vegf-therapy-for-patients-with-idiopathic-choroidal-neovascularization
#14
Xiaojuan Fan, Ning Gao, Jingming Li, Jianqin Lei, Qianyan Kang
The objective of this study is to investigate the levels of vascular endothelial growth factor (VEGF) and other cytokines in aqueous humor of patients with idiopathic choroidal neovascularization (CNV) and their effects together with central retinal thickness (CRT) on the response to intravitreal injection of anti-VEGF antibody ranibizumab. This clinical study recruited 32 eyes from 32 patients with CNV under or besides fovea. VEGF, interleukin (IL)-6, IL-8, and monocyte chemoattractant protein (MCP)-1 levels were detected in aqueous humor (0...
September 7, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28884200/spatial-distribution-of-early-red-lesions-is-a-risk-factor-for-development-of-vision-threatening-diabetic-retinopathy
#15
Giovanni Ometto, Phil Assheton, Francesco Calivá, Piotr Chudzik, Bashir Al-Diri, Andrew Hunter, Toke Bek
AIMS/HYPOTHESIS: Diabetic retinopathy is characterised by morphological lesions related to disturbances in retinal blood flow. It has previously been shown that the early development of retinal lesions temporal to the fovea may predict the development of treatment-requiring diabetic maculopathy. The aim of this study was to map accurately the area where lesions could predict progression to vision-threatening retinopathy. METHODS: The predictive value of the location of the earliest red lesions representing haemorrhages and/or microaneurysms was studied by comparing their occurrence in a group of individuals later developing vision-threatening diabetic retinopathy with that in a group matched with respect to diabetes type, age, sex and age of onset of diabetes mellitus who did not develop vision-threatening diabetic retinopathy during a similar observation period...
September 7, 2017: Diabetologia
https://www.readbyqxmd.com/read/28881490/diabetic-retinopathy-screening-using-deep-neural-network
#16
Nishanthan Ramachandran, Hong Sheng Chiong, Mary Jane Sime, Graham A Wilson
Importance There is a burgeoning interest in the use of deep neural network in diabetic retinal screening. BACKGROUND: To determine whether a deep neural network could satisfactorily detect diabetic retinopathy that requires referral to an ophthalmologist from a local diabetic retinal screening programme and an international database. Design Retrospective audit Samples Diabetic retinal photos from Otago database photographed during October 2016 (485 photos); and 1200 photos from Messidor international database...
September 7, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28881424/anatomic-relationship-of-the-first-olfactory-neuron-and-trochlea-cadaveric-study-with-surgical-implications
#17
Philip Locker, Max Plitt, Peter Papagiannopoulos, Ryan Smith, Bobby A Tajudeen
BACKGROUND: Iatrogenic injury to the trochlea is a potential complication of the Draf III or endoscopic modified Lothrop procedure; however, the location of the trochlea from within the sinus cavity has yet to be clearly characterized. We performed the first cadaveric study assessing the position of the trochlea in relation to the first olfactory neuron, a commonly identified landmark during the Draf III procedure. METHODS: Thirteen external dissections of the trochlea were performed on 7 disarticulated cadaveric heads via an extended Lynch type incision...
September 7, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28877965/tests-of-the-sorption-and-olfactory-fovea-hypotheses-in-the-mouse
#18
David Michael Coppola, Brittaney E Ritchie, Brent A Craven
The spatial distribution of receptors within sensory epithelia (e.g. retina and skin) is often markedly non-uniform to gain efficiency in information capture and neural processing. By contrast, odors, unlike visual and tactile stimuli, have no obvious spatial dimension. What need then could there be for either nearest-neighbor relationships or non-uniform distributions of receptor cells in the olfactory epithelium (OE)? Adrian (1942; 1950) provided the only widely debated answer to this question when he posited that the physical properties of odors, such as volatility and water solubility, determine a spatial pattern of stimulation across the OE that could aid odor discrimination...
September 6, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28875064/imaging-of-retinal-vascular-layers-adaptive-optics-scanning-laser-ophthalmoscopy-versus-optical-coherence-tomography-angiography
#19
Yoshihiro Kaizu, Shintaro Nakao, Iori Wada, Muneo Yamaguchi, Kohta Fujiwara, Shigeo Yoshida, Toshio Hisatomi, Yasuhiro Ikeda, Takehito Hayami, Tatsuro Ishibashi, Koh-Hei Sonoda
PURPOSE: Retinal vascular networks are observed as a layered structure residing in a nerve fiber layer and an inner nuclear layer of the retina. This study aimed to evaluate reflectance confocal adaptive optics scanning laser ophthalmoscopy (AO-SLO) for imaging of the layered retinal vascular networks. METHODS: This study included 16 eyes of 16 healthy cases. On the fovea, 2.8- and 3.0 mm(2)-areas were imaged using a prototype AO-SLO and optical coherence tomography angiography (OCTA), respectively...
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28874556/rpe65-has-an-additional-function-as-the-lutein-to-meso-zeaxanthin-isomerase-in-the-vertebrate-eye
#20
Rajalekshmy Shyam, Aruna Gorusupudi, Kelly Nelson, Martin P Horvath, Paul S Bernstein
Carotenoids are plant-derived pigment molecules that vertebrates cannot synthesize de novo that protect the fovea of the primate retina from oxidative stress and light damage. meso-Zeaxanthin is an ocular-specific carotenoid for which there are no common dietary sources. It is one of the three major carotenoids present at the foveal center, but the mechanism by which it is produced in the eye is unknown. An isomerase enzyme is thought to be responsible for the transformation of lutein to meso-zeaxanthin by a double-bond shift mechanism, but its identity has been elusive...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
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