Milagros C Romay, Russell H Knutsen, Feiyang Ma, Ana Mompeón, Gloria E Hernandez, Jocelynda Salvador, Snezana Mirkov, Ayush Batra, David P Sullivan, Daniele Procissi, Samuel Buchanan, Elise Kronquist, Elisa A Ferrante, William A Muller, Jordain Walshon, Alicia Steffens, Kathleen McCortney, Craig Horbinski, Elisabeth Tournier-Lasserve, Adam M Sonabend, Farzaneh A Sorond, Michael M Wang, Manfred Boehm, Beth A Kozel, M Luisa Iruela-Arispe
Vascular aging affects multiple organ systems, including the brain, where it can lead to vascular dementia. However, a concrete understanding of how aging specifically affects the brain vasculature, along with molecular readouts, remains vastly incomplete. Here, we demonstrate that aging is associated with a marked decline in Notch3 signaling in both murine and human brain vessels. To clarify the consequences of Notch3 loss in the brain vasculature, we used single-cell transcriptomics and found that Notch3 inactivation alters regulation of calcium and contractile function and promotes a notable increase in extracellular matrix...
January 16, 2024: Journal of Clinical Investigation