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https://www.readbyqxmd.com/read/28921391/effects-of-web-based-interventions-on-cancer-patients-symptoms-review-of-randomized-trials
#1
REVIEW
N Fridriksdottir, S Gunnarsdottir, S Zoëga, B Ingadottir, E J G Hafsteinsdottir
PURPOSE: Symptom management is of high priority in cancer care. Information and communication technology allows interventions to be provided through the internet to enhance the delivery of care. This study aimed to review the effects of web-based interventions on cancer patients' symptoms. METHODS: MEDLINE, PSychINFO, PubMed, CINAHL, and Cochrane databases were systematically searched. Included were randomized controlled trials (RCTs), pilot RCTs, or quasi-experimental (QE) studies focusing on web-based interventions in adult cancer patients with at least one outcome primary or secondary, in terms of symptoms, treatment side effects, or distress...
September 18, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28920534/analgesic-effects-of-gabapentin-and-buprenorphine-in-cats-undergoing-ovariohysterectomy-using-two-pain-scoring-systems-a-randomized-clinical-trial
#2
Paulo V Steagall, Javier Benito, Beatriz P Monteiro, Graeme M Doodnaught, Guy Beauchamp, Marina C Evangelista
Objectives The aim of the study was to evaluate the analgesic efficacy of gabapentin-buprenorphine in comparison with meloxicam-buprenorphine or buprenorphine alone, and the correlation between two pain-scoring systems in cats. Methods Fifty-two adult cats were included in a randomized, controlled, blinded study. Anesthetic protocol included acepromazine-buprenorphine-propofol-isoflurane. The gabapentin-buprenorphine group (GBG, n = 19) received gabapentin capsules (50 mg PO) and buprenorphine (0.02 mg/kg IM)...
September 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28916933/interactions-between-genetics-lifestyle-and-environmental-factors-for-healthcare
#3
Yuxin Lin, Jiajia Chen, Bairong Shen
The occurrence and progression of diseases are strongly associated with a combination of genetic, lifestyle, and environmental factors. Understanding the interplay between genetic and nongenetic components provides deep insights into disease pathogenesis and promotes personalized strategies for people healthcare. Recently, the paradigm of systems medicine, which integrates biomedical data and knowledge at multidimensional levels, is considered to be an optimal way for disease management and clinical decision-making in the era of precision medicine...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28916269/the-sterile-controversy-on-the-amyloid-cascade-hypothesis
#4
Marco Canevelli, Giuseppe Bruno, Matteo Cesari
In these last years, several phase III randomized controlled trials testing promising candidates sharing Aβ depots as target of their action have failed, despite showing some reductions of the brain Aβ charge. The announcements of the negative results have heated the discussion in the field and divided the scientific community between the defenders versus the opponents of the Aβ theory. In the present article, we discuss the limits of these drastic, opposite positions and we propose a novel approach to Alzheimer's disease (AD)...
September 12, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28905121/a-probabilistic-atlas-of-fiber-crossings-for-variability-reduction-of-anisotropy-measures
#5
Lukas J Volz, M Cieslak, S T Grafton
Diffusion imaging enables assessment of human brain white matter (WM) in vivo. WM microstructural integrity is routinely quantified via fractional anisotropy (FA). However, FA is also influenced by the number of differentially oriented fiber populations per voxel. To date, the precise statistical relationship between FA and fiber populations has not been characterized, complicating microstructural integrity assessment. Here, we used 630 state-of-the-art diffusion datasets from the Human Connectome Project, which allowed us to infer the number of fiber populations per voxel in a model-free fashion...
September 13, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28903685/evaluating-the-dimensionality-of-self-determination-theory-s-relative-autonomy-continuum
#6
Kennon M Sheldon, Evgeny N Osin, Tamara O Gordeeva, Dmitry D Suchkov, Oleg A Sychev
We conducted a theoretical and psychometric evaluation of self-determination theory's "relative autonomy continuum" (RAC), an important aspect of the theory whose validity has recently been questioned. We first derived a Comprehensive Relative Autonomy Index (C-RAI) containing six subscales and 24 items, by conducting a paired paraphrase content analysis of existing RAI measures. We administered the C-RAI to multiple U.S. and Russian samples, assessing motivation to attend class, study a major, and take responsibility...
September 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28900804/a-nonparametric-multidimensional-latent-class-irt-model-in-a-bayesian-framework
#7
Francesco Bartolucci, Alessio Farcomeni, Luisa Scaccia
We propose a nonparametric item response theory model for dichotomously-scored items in a Bayesian framework. The model is based on a latent class (LC) formulation, and it is multidimensional, with dimensions corresponding to a partition of the items in homogenous groups that are specified on the basis of inequality constraints among the conditional success probabilities given the latent class. Moreover, an innovative system of prior distributions is proposed following the encompassing approach, in which the largest model is the unconstrained LC model...
September 12, 2017: Psychometrika
https://www.readbyqxmd.com/read/28900407/psychometric-properties-of-a-multidimensional-scale-of-sense-of-community-in-the-school
#8
Gabriele Prati, Elvira Cicognani, Cinzia Albanesi
Sense of community in the school has been associated with a range of important outcomes for students. However, there are currently no standard definitions of sense of community in the school with corresponding measures with established psychometric properties. To fill this gap, the main aim of the present study was to propose a model of sense of community in the school, its operationalization and to examine its key psychometric properties (factorial structure, reliability, differential item functioning, differential test functioning of the scale and discriminant, convergent, and criterion validity)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28895484/patterns-relevance-and-predictors-of-heart-failure-dyadic-symptom-appraisal
#9
Christopher S Lee, James O Mudd, Jonathan Auld, Jill M Gelow, Shirin O Hiatt, Christopher V Chien, Julie T Bidwell, Karen S Lyons
BACKGROUND: Caregivers are thought to play a major role in helping patients first appraise and then respond to heart failure (HF) symptoms. AIMS: The aims of this study were to: (a) characterise distinct patterns of HF patient-caregiver dyads with respect to symptom appraisal; and (b) link dyadic symptom appraisal to contributions to self-care and caregiver strain. METHODS AND RESULTS: A cross-sectional dyadic descriptive design was used to capture patient and caregiver appraisal of patient HF symptoms (i...
October 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28894541/correlation-between-social-support-self-efficacy-and-health-promoting-behavior-in-hemodialysis-patients-hospitalized-in-karaj-in-2015
#10
Mahmoud Kiajamali, Meimanat Hosseini, Fatemeh Estebsari, Maliheh Nasiri, Tahereh Ashktorab, Amirhossein Abdi, Aazam Mahmoudi, Atefe Salimi Akin Abadi
BACKGROUND: In hemodialysis, as a choice of treatment due to long treatment duration, the patient encounters limitations. Perceived social support, perceived self-efficacy and health promoting activities are important strategies to facilitate and maintain their health. AIM: To determine the correlation between social support, self-efficacy and health promoting behaviors in hemodialysis patients hospitalized in Karaj city in 2015. METHODS: This cross-sectional descriptive correlational study was carried out on 200 hemodialysis patients who were selected from four hospitals in Karaj based on cluster sampling...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28889351/multidimensional-phenotyping-of-breast-cancer-cell-lines-to-guide-preclinical-research
#11
Jodi M Saunus, Chanel E Smart, Jamie R Kutasovic, Rebecca L Johnston, Priyakshi Kalita-de Croft, Mariska Miranda, Esdy N Rozali, Ana Cristina Vargas, Lynne E Reid, Eva Lorsy, Sibylle Cocciardi, Tatjana Seidens, Amy E McCart Reed, Andrew J Dalley, Leesa F Wockner, Julie Johnson, Debina Sarkar, Marjan E Askarian-Amiri, Peter T Simpson, Kum Kum Khanna, Georgia Chenevix-Trench, Fares Al-Ejeh, Sunil R Lakhani
PURPOSE: Cell lines are extremely useful tools in breast cancer research. Their key benefits include a high degree of control over experimental variables and reproducibility. However, the advantages must be balanced against the limitations of modelling such a complex disease in vitro. Informed selection of cell line(s) for a given experiment now requires essential knowledge about molecular and phenotypic context in the culture dish. METHODS: We performed multidimensional profiling of 36 widely used breast cancer cell lines that were cultured under standardised conditions...
September 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28889328/the-work-role-functioning-questionnaire-v2-0-showed-consistent-factor-structure-across-six-working-samples
#12
Femke I Abma, Ute Bültmann, Benjamin C Amick Iii, Iris Arends, Heleen F Dorland, Peter A Flach, Jac J L van der Klink, Hardy A van de Ven, Jakob Bue Bjørner
Objective The Work Role Functioning Questionnaire v2.0 (WRFQ) is an outcome measure linking a persons' health to the ability to meet work demands in the twenty-first century. We aimed to examine the construct validity of the WRFQ in a heterogeneous set of working samples in the Netherlands with mixed clinical conditions and job types to evaluate the comparability of the scale structure. Methods Confirmatory factor and multi-group analyses were conducted in six cross-sectional working samples (total N = 2433) to evaluate and compare a five-factor model structure of the WRFQ (work scheduling demands, output demands, physical demands, mental and social demands, and flexibility demands)...
September 9, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28887786/assessing-psycho-social-barriers-to-rehabilitation-in-injured-workers-with-chronic-musculoskeletal-pain-development-and-item-properties-of-the-yellow-flag-questionnaire-yfq
#13
Cornelia Rolli Salathé, Maurizio Alen Trippolini, Livio Claudio Terribilini, Michael Oliveri, Achim Elfering
Purpose To develop a multidimensional scale to asses psychosocial beliefs-the Yellow Flag Questionnaire (YFQ)-aimed at guiding interventions for workers with chronic musculoskeletal (MSK) pain. Methods Phase 1 consisted of item selection based on literature search, item development and expert consensus rounds. In phase 2, items were reduced with calculating a quality-score per item, using structure equation modeling and confirmatory factor analysis on data from 666 workers. In phase 3, Cronbach's α, and Pearson correlations coefficients were computed to compare YFQ with disability, anxiety, depression and self-efficacy and the YFQ score based on data from 253 injured workers...
September 8, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28887380/proteomic-signature-reveals-modulation-of-human-macrophage-polarization-and-functions-under-differing-environmental-oxygen-conditions
#14
Magali Court, Graciane Petre, Michèle El-Atifi, Arnaud Millet
Macrophages are innate immune cells which can react to a large number of environmental stimuli thanks to a high degree of plasticity. These cells are involved in a variety of tissue functions in homeostasis, and they play essential roles in pathological contexts. Macrophages’ activation state, which determines their functional orientation, is strongly influenced by the cellular environment. A large body of macrophage literature is devoted to better defining polarizations from a molecular viewpoint. It is now accepted that a multidimensional model of polarization is needed to grasp the broad phenotype repertoire controlled by environmental signals...
September 8, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28886653/a-coherent-discrete-variable-representation-method-on-a-sphere
#15
Hua-Gen Yu
The coherent discrete variable representation (ZDVR) has been extended for constructing a multidimensional potential-optimized DVR basis on a sphere. In order to deal with the non-constant Jacobian in spherical angles, two direct product primitive basis methods are proposed so that the original ZDVR technique can be properly implemented. The method has been demonstrated by computing the lowest states of a two-dimensional (2D) vibrational model. Results show that the extended ZDVR method gives accurate eigenvalues and exponential convergence with increasing ZDVR basis size...
September 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28886556/developing-an-integrated-3d-hydrodynamic-and-emerging-contaminant-model-for-assessing-water-quality-in-a-yangtze-estuary-reservoir
#16
Cong Xu, Jingjie Zhang, Xiaowei Bi, Zheng Xu, Yiliang He, Karina Yew-Hoong Gin
An integrated 3D-hydrodynamic and emerging contaminant model was developed for better understanding of the fate and transport of emerging contaminants in Qingcaosha Reservoir. The reservoir, which supplies drinking water for nearly half of Shanghai's population, is located in Yangtze Delta. The integrated model was built by Delft3D suite, a fully integrated multidimensional modeling software. Atrazine and Bisphenol A (BPA) were selected as two representative emerging contaminants for the study in this reservoir...
August 23, 2017: Chemosphere
https://www.readbyqxmd.com/read/28886176/material-wealth-in-3d-mapping-multiple-paths-to-prosperity-in-low-and-middle-income-countries
#17
Daniel J Hruschka, Craig Hadley, Joseph Hackman
Material wealth is a key factor shaping human development and well-being. Every year, hundreds of studies in social science and policy fields assess material wealth in low- and middle-income countries assuming that there is a single dimension by which households can move from poverty to prosperity. However, a one-dimensional model may miss important kinds of prosperity, particularly in countries where traditional subsistence-based livelihoods coexist with modern cash economies. Using multiple correspondence analysis to analyze representative household data from six countries-Nepal, Bangladesh, Ethiopia, Kenya, Tanzania and Guatemala-across three world regions, we identify a number of independent dimension of wealth, each with a clear link to locally relevant pathways to success in cash and agricultural economies...
2017: PloS One
https://www.readbyqxmd.com/read/28885534/an-organizational-model-for-excellence-in-healthcare-delivery-evidence-from-winners-of-the-baldrige-quality-award
#18
John R Griffith
Winners of the Baldrige National Quality Award in healthcare have documented top quartile clinical outcomes and patient satisfaction across a variety of American communities and a full spectrum of care. Their results also show high levels of satisfaction among physicians, nurses, and other workers, as well as effective financial performance. The managerial methods they use-collectively, the Baldrige model-are consistent with organizational theory literature and are found across all winners. The winners have sustained excellence after winning and expanded it by acquisition of other healthcare organizations...
September 2017: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28884246/impulsivity-dimensions-and-risky-sex-behaviors-in-an-at-risk-young-adult-sample
#19
Inga Curry, Jeremy W Luk, Ryan S Trim, Christian J Hopfer, John K Hewitt, Michael C Stallings, Sandra A Brown, Tamara L Wall
Impulsivity is a personality-based risk factor that has been well studied in relation to risky sexual behavior. Recent conceptualizations of impulsivity have proposed multidimensional facets comprised of premeditation, perseverance, sensation seeking, negative urgency, and positive urgency (UPPS-P model). Prior studies have found that these facets are associated with risky sexual behavior in adolescent and college student samples, but no prior studies have evaluated them in clinical samples. The current study examined how impulsivity-related traits related to two different risky sexual behaviors in a clinical sample of at-risk young adults who had both conduct disorder and substance use disorder symptoms as adolescents (n = 529)...
September 7, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28882539/multidimensional-effects-of-voice-therapy-in-patients-affected-by-unilateral-vocal-fold-paralysis-due-to-cancer
#20
Camila Barbosa Barcelos, Paula Angélica Lorenzon Silveira, Renata Lígia Vieira Guedes, Aline Nogueira Gonçalves, Luciana Dall'Agnol Siqueira Slobodticov, Elisabete Carrara-de Angelis
INTRODUCTION: Patients with unilateral vocal fold paralysis may demonstrate different degrees of voice perturbation depending on the position of the paralyzed vocal fold. Understanding the effectiveness of voice therapy in this population may be an important coefficient to define the therapeutic approach. OBJECTIVE: To evaluate the voice therapy effectiveness in the short, medium and long-term in patients with unilateral vocal fold paralysis and determine the risk factors for voice rehabilitation failure...
August 24, 2017: Brazilian Journal of Otorhinolaryngology
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