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https://www.readbyqxmd.com/read/29350455/a-novel-prognostic-six-cpg-signature-in-glioblastomas
#1
An-An Yin, Nan Lu, Amandine Etcheverry, Marc Aubry, Jill Barnholtz-Sloan, Lu-Hua Zhang, Jean Mosser, Wei Zhang, Xiang Zhang, Yu-He Liu, Ya-Long He
AIMS: We aimed to identify a clinically useful biomarker using DNA methylation-based information to optimize individual treatment of patients with glioblastoma (GBM). METHODS: A six-CpG panel was identified by incorporating genome-wide DNA methylation data and clinical information of three distinct discovery sets and was combined using a risk-score model. Different validation sets of GBMs and lower-grade gliomas and different statistical methods were implemented for prognostic evaluation...
January 19, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29347343/dissipation-lag-and-drift-in-driven-fluctuating-systems
#2
Diego Frezzato
This work deals with thermostated fluctuating systems subjected to driven transformations of the internal energetics. The main focus is on generally multidimensional systems with continuous configurational degrees of freedom over which overdamped Markovian fluctuations take place (diffusive regime of the motion). Mutual bounds are established between the average energy dissipation, the deviation between nonequilibrium probability density and underlying equilibrium distribution due to the system's lag, and the statistical properties of the components of the directed flow induced by the transformation itself...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347283/stochastic-wave-function-unravelling-of-the-generalized-lindblad-equation
#3
V Semin, I Semina, F Petruccione
We investigate generalized non-Markovian stochastic Schrödinger equations (SSEs), driven by a multidimensional counting process and multidimensional Brownian motion introduced by A. Barchielli and C. Pellegrini [J. Math. Phys. 51, 112104 (2010)JMAPAQ0022-248810.1063/1.3514539]. We show that these SSEs can be translated in a nonlinear form, which can be efficiently simulated. The simulation is illustrated by the model of a two-level system in a structured bath, and the results of the simulations are compared with the exact solution of the generalized master equation...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346518/determinants-of-health-trajectories-in-england-and-the-us-an-approach-to-identify-different-patterns-of-healthy-aging
#4
Javier de la Fuente, Francisco Félix Caballero, Albert Sánchez-Niubó, Demosthenes B Panagiotakos, Matthew A Prina, Holger Arndt, Josep Maria Haro, Somnath Chatterji, José Luis Ayuso-Mateos
Background: Aging is a multidimensional process with a remarkable inter-individual variability. This study is focused on identifying groups of population with similar aging patterns, and to define the health trajectories of these groups. Socio-demographic and health determinants of these trajectories are also identified. Methods: Data from the English Longitudinal Study of Aging (ELSA) and the Health and Retirement Study (HRS) were used. A set of self-reported health items and measured tests were used to generate a latent health metric by means of a Bayesian multilevel IRT model, assessing the ability of the metric to predict mortality...
January 16, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29345329/generating-quantitative-cell-identity-labels-with-marker-enrichment-modeling-mem
#5
Kirsten E Diggins, Jocelyn S Gandelman, Caroline E Roe, Jonathan M Irish
Multiplexed single-cell experimental techniques like mass cytometry measure 40 or more features and enable deep characterization of well-known and novel cell populations. However, traditional data analysis techniques rely extensively on human experts or prior knowledge, and novel machine learning algorithms may generate unexpected population groupings. Marker enrichment modeling (MEM) creates quantitative identity labels based on features enriched in a population relative to a reference. While developed for cell type analysis, MEM labels can be generated for a wide range of multidimensional data types, and MEM works effectively with output from expert analysis and diverse machine learning algorithms...
January 18, 2018: Current Protocols in Cytometry
https://www.readbyqxmd.com/read/29344525/psychometric-properties-of-the-communication-skills-attitude-scale-csas-measure-in-a-sample-of-iranian-medical-students
#6
Afsaneh Yakhforoshha, Mandana Shirazi, Naser Yousefzadeh, Amin Ghanbarnejad, Mohammadali Cheraghi, Rita Mojtahedzadeh, Behrooz Mahmoodi-Bakhtiari, Seyed Amir Hossein Emami
Introduction: Communication skill (CS) has been regarded as one of the fundamental competencies for medical and other health care professionals. Student's attitude toward learning CS is a key factor in designing educational interventions. The original CSAS, as positive and negative subscales, was developed in the UK; however, there is no scale to measure these attitudes in Iran. The aim of this study was to assess the psychometric characteristic of the Communication Skills Attitude Scale (CSAS), in an Iranian context and to understand if it is a valid tool to assess attitude toward learning communication skills among health care professionals...
January 2018: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/29344049/a-structural-equation-model-of-self-care-activities-in-diabetic-elderly-patients
#7
Mousa Alavi, Razieh Molavi, Parvin Eslami
Background: Self-care is a valuable strategy to improve health and reduce events of hospitalization and the duration of hospital stay in elderly diabetic patients. This study aimed to examine the model of self-care behaviors in elderly diabetic patients. Materials and Methods: A survey was conducted among 209 diabetic elderly patients who were admitted in three hospitals affiliated with the Isfahan University of Medical Sciences, Iran. Convenience sampling method was used to recruit the participants...
January 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29340895/confirming-the-tripartite-structure-of-the-duke-university-religion-index-a-methodological-approach
#8
John W Lace, Paul J Handal
The present study provided a methodological critique regarding psychometric investigations of the Duke University Religion Index (DUREL) and its variants. Nine hundred seventeen (630 females and 287 males) university students (M age = 19.24) completed the DUREL, the Personal Religious Inventory, and the Daily Spiritual Experiences Scale online. Confirmatory factor analyses were performed to assess a three-factor (organizational religious activity; non-organizational religious activity; and intrinsic religiosity) and a unidimensional model of the DUREL...
January 16, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29340773/feature-codes-in-implicit-sequence-learning-perceived-stimulus-locations-transfer-to-motor-response-locations
#9
Hilde Haider, Sarah Esser, Katharina Eberhardt
An important question in implicit sequence learning research is how the learned information is represented. In earlier models, the representations underlying implicit learning were viewed as being either purely motor or perceptual. These different conceptions were later integrated by multidimensional models such as the Dual System Model of Keele et al. (Psychol Rev 110(2):316-339, 2003). According to this model, different types of sequential information can be learned in parallel, as long as each sequence comprised only one single dimension (e...
January 16, 2018: Psychological Research
https://www.readbyqxmd.com/read/29338802/separating-common-from-unique-variance-within-emotional-distress-an-examination-of-reliability-and-relations-to-worry
#10
Andrew J Marshall, Emma K Evanovich, Sarah Jo David, Gregory H Mumma
BACKGROUND: High comorbidity rates among emotional disorders have led researchers to examine transdiagnostic factors that may contribute to shared psychopathology. Bifactor models provide a unique method for examining transdiagnostic variables by modelling the common and unique factors within measures. Previous findings suggest that the bifactor model of the Depression Anxiety and Stress Scale (DASS) may provide a method for examining transdiagnostic factors within emotional disorders...
January 17, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29337287/revealing-determinants-of-two-phase-dynamics-of-p53-network-under-gamma-irradiation-based-on-a-reduced-2d-relaxation-oscillator-model
#11
Gökhan Demirkıran, Güleser Kalaycı Demir, Cüneyt Güzeliş
This study proposes a two-dimensional (2D) oscillator model of p53 network, which is derived via reducing the multidimensional two-phase dynamics model into a model of ataxia telangiectasia mutated (ATM) and Wip1 variables, and studies the impact of p53-regulators on cell fate decision. First, the authors identify a 6D core oscillator module, then reduce this module into a 2D oscillator model while preserving the qualitative behaviours. The introduced 2D model is shown to be an excitable relaxation oscillator...
February 2018: IET Systems Biology
https://www.readbyqxmd.com/read/29336515/expectations-and-experiences-of-patients-with-osteoarthritis-undergoing-total-joint-arthroplasty-an-integrative-review
#12
Min Ting Alicia See, Yanika Kowitlawakul, Apphia Jia Qi Tan, Sok Ying Liaw
BACKGROUND: The effectiveness of educational interventions for osteoarthritic patients undergoing total joint arthroplasty remains inconclusive. It is essential to understand the educational needs of these patients from their perspectives. AIM: The aim of this study was to systematically summarize and synthesize osteoarthritic patients' expectations and experiences in undergoing total joint arthroplasty to identify their educational needs. DESIGN: An integrative review was conducted...
January 16, 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29335655/a-bifactor-approach-to-model-multifaceted-constructs-in-statistical-mediation-analysis
#13
Oscar Gonzalez, David P MacKinnon
Statistical mediation analysis allows researchers to identify the most important mediating constructs in the causal process studied. Identifying specific mediators is especially relevant when the hypothesized mediating construct consists of multiple related facets. The general definition of the construct and its facets might relate differently to an outcome. However, current methods do not allow researchers to study the relationships between general and specific aspects of a construct to an outcome simultaneously...
2018: Educational and Psychological Measurement
https://www.readbyqxmd.com/read/29332151/1h-13c-and-15n-backbone-and-partial-side-chain-resonance-assignments-of-the-c-terminal-domain-of-hiv-1-pr55gag-encompassed-in-ncp15
#14
Valéry Larue, Marjorie Catala, Anissa Belfetmi, Loussiné Zargarian, Olivier Mauffret, Carine Tisné
During HIV-1 assembly, the Pr55Gag polyprotein precursor (Gag) interacts with the genomic RNA, with lipids of the plasma membrane, with host proteins (ALIX, TSG101) through the ESCRT complex, with the viral protein Vpr and are involved in intermolecular interactions with other Pr55Gag proteins. This network of interactions is responsible for the formation of the viral particle, the selection of genomic RNA and the packaging of Vpr. The C-terminal domain of Gag encompassed in NCp15 is involved in the majority of these interactions, either by its nucleocapsid or its p6 domains...
January 13, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29331743/preliminary-investigation-of-human-exhaled-breath-for-tuberculosis-diagnosis-by-multidimensional-gas-chromatography-time-of-flight-mass-spectrometry-and-machine-learning
#15
Marco Beccaria, Theodore R Mellors, Jacky S Petion, Christiaan A Rees, Mavra Nasir, Hannah K Systrom, Jean W Sairistil, Marc-Antoine Jean-Juste, Vanessa Rivera, Kerline Lavoile, Patrice Severe, Jean W Pape, Peter F Wright, Jane E Hill
Tuberculosis (TB) remains a global public health malady that claims almost 1.8 million lives annually. Diagnosis of TB represents perhaps one of the most challenging aspects of tuberculosis control. Gold standards for diagnosis of active TB (culture and nucleic acid amplification) are sputum-dependent, however, in up to a third of TB cases, an adequate biological sputum sample is not readily available. The analysis of exhaled breath, as an alternative to sputum-dependent tests, has the potential to provide a simple, fast, and non-invasive, and ready-available diagnostic service that could positively change TB detection...
January 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29329916/impact-of-the-international-nosocomial-infection-control-consortium-s-multidimensional-approach-on-rates-of-ventilator-associated-pneumonia-in-14-intensive-care-units-in-11-hospitals-of-5-cities-within-argentina
#16
Victor Daniel Rosenthal, Javier Desse, Diego Marcelo Maurizi, Gustavo Jorge Chaparro, Pablo Wenceslao Orellano, Viviana Chediack, Rafael Cabrera, Daniel Golschmid, Cristina Graciela Silva, Julio Cesar Vimercati, Juan Pablo Stagnaro, Ivanna Perez, María Laura Spadaro, Adriana Miriam Montanini, Dina Pedersen, Teresa Laura Paniccia, Ana María Ríos Aguilera, Raul Cermesoni, Juan Ignacio Mele, Ernesto Alda, Analía Edith Paldoro, Agustín Román Ortta, Bettina Cooke, María Cecilia García, Mora Nair Obed, Cecilia Verónica Domínguez, Pablo Alejandro Saúl, María Cecilia Rodríguez Del Valle, Alberto Claudio Bianchi, Gustavo Alvarez, Ricardo Pérez, Carolina Oyola
BACKGROUND: To analyze the impact of the International Nosocomial Infection Control Consortium (INICC) multidimensional approach (IMA) on ventilator-associated pneumonia (VAP) rates in 11 hospitals within 5 cities of Argentina from January 2014-April 2017. METHODS: A multicenter, prospective, before-after surveillance study was conducted through the use of International Nosocomial Infection Control Consortium Surveillance Online System. During baseline, we performed outcome surveillance of VAP applying the definitions of the Centers for Disease Control andPrevention's National Healthcare Safety Network...
January 9, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29325599/are-we-there-yet-an-update-on-transitional-care-in-rheumatology
#17
EDITORIAL
Janet E McDonagh, Albert Farre
Significant progress has been made in the understanding of transitional care in rheumatology over the last few decades, yet universal implementation has not been realised and unmet needs continue to be reported. Possible explanations for this include lack of evidence as to which model is most effective; lack of attention to the multiple dimensions, stakeholders and systems involved in health transitions; and lack of consideration of the developmental appropriateness of transition interventions and the services/organisations/systems where such interventions are delivered...
January 11, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29323511/representing-schizotypal-thinking-with-dimensional-traits-a-case-for-the-five-factor-schizotypal-inventory
#18
Erin L Moorman, Douglas B Samuel
Building on support for the five-factor model (FFM) of personality disorder, the Five Factor Schizotypal Inventory (FFSI) was developed to assess maladaptive traits relevant to schizotypal personality disorder. While the development of the FFSI supports a continuity between schizotypal thinking and perception (STAP) and the FFM domain of Openness to Experience, other studies show inconsistent findings concerning the strength of this relationship. The current study evaluates these relationships by investigating specific components of a short-form of the FFSI (e...
January 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29322785/triptolide-induces-mitochondrial-apoptosis-through-modulating-dual-specificity-phosphatase-1-mitogen-activated-protein-kinases-cascade-in-osteosarcoma-cells
#19
W Qin, S Li, Y Miao, Q Shi, Y Wang, J Li, Z Chen, J Wang, C Ling
Due to chemoresistance and metastasis, the overall prognosis of osteosarcoma (OS) has not improved over the last two decades. Exploring novel therapeutic agents that can circumvent theses malignant phenotypes of OS would be essential to improve the survival of OS patients. Triptolide is a unique diterpene triepoxide that possesses potent antitumor activities.However, the effects and mechanism of triptolide on OS cells remain unknown. The effects of triptolide on viability, apoptosis, cell cycle distribution and migratory ability of OS cells were measured using MTT, flow cytometry and wound healing and transwell invasion assays...
2018: Neoplasma
https://www.readbyqxmd.com/read/29316883/active-ingredients-of-a-person-centred-intervention-for-people-on-hiv-treatment-analysis-of-mixed-methods-trial-data
#20
Keira Lowther, Richard Harding, Victoria Simms, Aabid Ahmed, Zipporah Ali, Nancy Gikaara, Lorraine Sherr, Hellen Kariuki, Irene J Higginson, Lucy Ellen Selman
BACKGROUND: A new model of care is required to meet the changing needs of people living with HIV (PLWH), particularly in low and middle-income countries, where prevalence is highest. We evaluated a palliative care intervention for PLWH in Mombasa, Kenya. Although we found no effect on pain (primary outcome), there was a positive effect on mental health (secondary outcome) in the intervention group. To inform replication and implementation, we have determined the active ingredients of the intervention and their mechanisms of action...
January 10, 2018: BMC Infectious Diseases
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