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JOURNAL ARTICLE
Kaustubh Supekar, Carlo de Los Angeles, Srikanth Ryali, Leila Kushan, Charlie Schleifer, Gabriela Repetto, Nicolas A Crossley, Tony Simon, Carrie E Bearden, Vinod Menon
A major genetic risk factor for psychosis is 22q11.2 deletion (22q11.2DS). However, robust and replicable functional brain signatures of 22q11.2DS and 22q11.2DS-associated psychosis remain elusive due to small sample sizes and a focus on small single-site cohorts. Here, we identify functional brain signatures of 22q11.2DS and 22q11.2DS-associated psychosis, and their links with idiopathic early psychosis, using one of the largest multi-cohort data to date. We obtained multi-cohort clinical phenotypic and task-free fMRI data from 856 participants (101 22q11...
April 12, 2024: Molecular Psychiatry
#22
JOURNAL ARTICLE
Xue Wang, Yibo Wu, Yu Chen, Qian Gao, Wenting Liu, Jiayi Xu, Shuang Zang
BACKGROUND: The Coronavirus Disease-2019 (COVID-19) pandemic has had a profound impact on suboptimal health status, depression, and anxiety, necessitating a comprehensive understanding of their inter-relationships at the national level. This study aims to investigate the inter-relationships among suboptimal health status, depression, and anxiety using a network analysis approach. METHODS: We conducted a national survey between June 20 and August 31, 2022. Three network models were constructed and analyzed to independently examine the inter-relationships among suboptimal health status, depression, and anxiety...
April 9, 2024: Journal of Affective Disorders
#23
JOURNAL ARTICLE
Austin Spadaro, Alok Sharma, Iman Dehzangi
Protein lysine methylation is a particular type of post translational modification that plays an important role in both histone and non-histone function regulation in proteins. Deregulation caused by lysine methyltransferases has been identified as the cause of several diseases including cancer as well as both mental and developmental disorders. Identifying lysine methylation sites is a critical step in both early diagnosis and drug design. This study proposes a new Machine Learning method called CNN-Meth for predicting lysine methylation sites using a convolutional neural network (CNN)...
April 9, 2024: Methods: a Companion to Methods in Enzymology
#24
JOURNAL ARTICLE
Gisele Magarotto Machado, Felipe Valentini, David Watson, Lucas de Francisco Carvalho
The Inventory of Depression and Anxiety Symptoms-Expanded version (IDAS-II) is one of the few tools designed to assess internalizing symptoms based on dimensional models. We conducted two studies, the first testing internal validity aspects of the IDAS-II and the second testing the external validity of the scales. In the first study we adapted the IDAS-II to Brazilian Portuguese and tested its internal structure, including a higher order factorial solution coherent with the internalizing spectrum, the stability of the factor structure, and its measurement invariance for sex and racial groups...
April 11, 2024: Psychological Assessment
#25
JOURNAL ARTICLE
Lauren A Szczygiel, Amanda K Greene, Christina M Cutter, Rochelle D Jones, Eva L Feldman, Kelly C Paradis, Isis H Settles, Kanakadurga Singer, Nancy D Spector, Abigail J Stewart, Peter A Ubel, Reshma Jagsi
IMPORTANCE: Despite increasing evidence and recognition of persistent gender disparities in academic medicine, qualitative data detailing the association of gender-based experiences with career progression remain sparse, particularly at the mid- to senior-career stage. OBJECTIVE: To investigate the role gender has played in everyday professional experiences of mid- to senior-career women clinician-scientists and their perceptions of gender-related barriers experienced across their careers...
April 1, 2024: JAMA Network Open
#26
JOURNAL ARTICLE
Xiaotian T Fang, Nakul R Raval, Ryan S O'Dell, Mika Naganawa, Adam P Mecca, Ming-Kai Chen, Christopher H van Dyck, Richard E Carson
Synaptic loss is a primary pathology in Alzheimer's disease and correlates best with cognitive impairment as found in post-mortem studies. Previously, we observed in vivo reductions of synaptic density with [11 C]UCB-J PET (radiotracer for synaptic vesicle protein 2A) throughout the neocortex and medial temporal brain regions in early Alzheimer's disease. In this study, we applied independent component analysis to synaptic vesicle protein 2A-PET data to identify brain networks associated with cognitive deficits in Alzheimer's disease in a blinded data-driven manner...
2024: Brain communications
#27
REVIEW
Aletta Me Millen, William Mu Daniels, Sooraj Baijnath
In Africa, there is currently a paucity of data on the epidemiology of depression, its treatment and management. The prevalence of depression is severely underestimated, with unique circumstances and societal risk factors associated with depression and its public awareness. Treating and managing depression is confounded by an inaccessibility to efficient and low-cost treatments for patients with depression. The aetiology of depression is multifactorial, with various theories implicating multiple neuronal networks...
April 15, 2024: Heliyon
#28
REVIEW
Joost Dekker, Elise Doppenberg-Smit, Annemarie Braamse, Femke Lamers, Myra van Linde, Henk M W Verheul, Mirjam Sprangers, Aartjan T F Beekman
Cancer and its associated treatment is a major stressor, leading to emotions such as anxiety or depressive mood. Human emotions have developed through the course of evolution because they facilitate adaptation to important events, such as cancer and its associated treatment. On the other hand, emotions can be maladaptive and interfere with adaptation to cancer. Emotions are maladaptive if they are disproportionally severe or persistent, and if they interfere with functioning. We aim to expand the conceptualization of adaptive and maladaptive emotions in patients with cancer...
2024: Frontiers in Psychiatry
#29
JOURNAL ARTICLE
Dallis Alvarez, Harry Adynski, Rebeca Harris, Baiming Zou, Jacquelyn Y Taylor, Hudson P Santos
BACKGROUND: Discrimination, or unfair treatment based on individual characteristics such as gender, race, skin color, and or sexual orientation, is a pervasive social stressor that perpetuates health disparities by limiting social and economic opportunity and is associated with poor mental and physical health outcomes. AIMS: The purpose of the present study is to (1) examine the association between maternal experiences of discrimination and paternal experiences of discrimination; (2) explore how discrimination relates to parental (maternal and paternal) stress and depressive symptoms; and (3) examine whether social support exerts protective effects...
April 11, 2024: Journal of the American Psychiatric Nurses Association
#30
JOURNAL ARTICLE
Ruining Wang, Baojuan Ye, Peiyi Wang
Social media platforms play a significant role in the lives of young people. While the usage of these platforms has grown, research exploring the challenges of body image remains limited. This study investigated whether initiating negative body talk functioned as an indirect pathway between appearance comparison on social media and body shame and whether perceived sociocultural influences from parents, friends, and media on body image moderated this indirect effect. An online cross-sectional survey of 795 Chinese college students ( M age = 20...
April 10, 2024: Journal of Health Psychology
#31
JOURNAL ARTICLE
O Ali-Saleh, S Bord, F Basis
BACKGROUND: Reports have shown that women suffered from anxiety, stress, depression, and fatigue during the COVID-19 pandemic more than men. No study so far has examined the effect of the pandemic among the Arab minority in Israel. OBJECTIVES: To examine the associations between levels of pandemic fatigue and stress of Israeli Arab women, and their anxiety and depression, along with their socio-demographic and socio-economic characteristics. METHODS: A Cohen and Williamson questionnaire, which was based on a Likert scale, was distributed by the snowball method through social networks...
April 10, 2024: Journal of Racial and Ethnic Health Disparities
#32
JOURNAL ARTICLE
Yulin Yang, Wanpeng Chang, Jiangtao Ding, Hongli Xu, Xiao Wu, Lihong Ma, Yanwen Xu
OBJECTIVE: The study aimed to evaluate, using a network meta-analysis, the effects of different transcranial magnetic stimulation (TMS) modalities on improving cognitive function after stroke. METHODS: Computer searches of the Cochrane Library, PubMed, Web of Science, Embass, Google Scholar, CNKI, and Wanfang databases were conducted to collect randomized controlled clinical studies on the use of TMS to improve cognitive function in stroke patients, published from the time of database construction to November 2023...
April 11, 2024: Neurological Sciences
#33
JOURNAL ARTICLE
Cheryl Su Ling Sim, P V Asharani, Mythily Subramaniam, Huso Yi
Globally, COVID-19 had an immense impact on mental health systems, but research on how community mental health (CMH) systems and services contributed to the pandemic mental health response is limited. We conducted a systematic review and meta-ethnography to understand the roles of CMH services, determinants of the quality of CMH care, and dynamics within CMH systems during COVID-19. We searched and screened across five databases and appraised study quality using the CASP tool, which yielded 27 qualitative studies...
December 31, 2024: Health Systems and Reform
#34
JOURNAL ARTICLE
Patrick Thomson, Amber L Pearson, Emily Kumpel, Danice B Guzmán, Cassandra L Workman, David Fuente, Amber Wutich, Justin Stoler
Water supply interruptions contribute to household water insecurity. Unpredictable interruptions may particularly exacerbate water insecurity, as uncertainty limits households' ability to optimize water collection and storage or to modify other coping behaviors. This study used regression models of survey data from 2873 households across 10 sites in 9 middle-income countries to assess whether water supply interruptions and the predictability of interruptions were related to composite indicators of stressful behaviors and emotional distress...
April 10, 2024: Environmental Science & Technology
#35
JOURNAL ARTICLE
Nissa Towe-Goodman, Kristen L McArthur, Michael Willoughby, Margaret M Swingler, Cara Wychgram, Allan C Just, Itai Kloog, Deborah H Bennett, Daniel Berry, Marnie F Hazlehurst, Peter James, Marcia Pescador Jimenez, Jin-Shei Lai, Leslie D Leve, Lisa Gatzke-Kopp, Julie B Schweitzer, Traci A Bekelman, Catrina Calub, Susan Carnell, Sean Deoni, Viren D'Sa, Carrie Kelly, Daphne Koinis-Mitchell, Michael Petriello, Gita Thapaliya, Rosalind J Wright, Xueying Zhang, Amii M Kress
IMPORTANCE: Evidence suggests that living near green space supports mental health, but studies examining the association of green space with early mental health symptoms among children are rare. OBJECTIVE: To evaluate the association between residential green space and early internalizing (eg, anxiety and depression) and externalizing (eg, aggression and rule-breaking) symptoms. DESIGN, SETTING, AND PARTICIPANTS: Data for this cohort study were drawn from the Environmental Influences on Child Health Outcomes cohort; analysis was conducted from July to October 2023...
April 1, 2024: JAMA Network Open
#36
JOURNAL ARTICLE
Giorgio A Tasca
At the centre of POR is the concept of collaboration between patients, therapists, agencies, and third-party payers. For this commentary, I review the articles of the special issue with attention to both the opportunities and challenges offered by practice-oriented research (POR). I also reviewed some previous research on practice-research networks and how that research might inform POR. The use of routine outcome monitoring (ROM), artificial intelligence (AI), and program evaluation (PE) models show promise for advancing POR...
April 10, 2024: Administration and Policy in Mental Health
#37
JOURNAL ARTICLE
Cesáreo Fernández Alonso, Manuel E Fuentes Ferrer, Eric Jorge García-Lamberechts, Sira Aguiló Mir, Sònia Jiménez, Javier Jacob, Pascual Piñera Salmerón, Adriana Gil-Rodrigo, Pere Llorens, Guillermo Burillo-Putze, Aitor Alquezar-Arbé, Sierra Bretones Baena, María Fernández Cardona, Rocío Hernández González, Miguel Moreno Martín, Ana Barnes Parra, Imane El Farh, Beatriz Valle Borrego, Eva Quero Motto, Alberto Artieda Larrañaga, Ester Soy Ferrer, Jeong-Uh Hong Cho, Belén Gros Bañeres, Sara Gayoso Martín, Goretti Sánchez Sindín, Azucena Prieto Zapico, Isabel Cirera Lorenzo, José María Guardiola Tey, Lluís Llauger, Juan González Del Castillo, Òscar Miró
OBJECTIVES: To assess whether dementia is an independent predictor of death after a hospital emergency department (ED) visit by older adults with or without a COVID-19 diagnosis during the first pandemic wave. METHOD: We used data from the EDEN-Covid (Emergency Department and Elderly Needs during Covid) cohort formed by all patients ≥65 years seen in 52 Spanish EDs from March 30 to April 5, 2020. The association of prior history of dementia with mortality at 30, 180 and 365 d was evaluated in the overall sample and according to a COVID-19 or non COVID diagnosis...
April 10, 2024: Aging & Mental Health
#38
JOURNAL ARTICLE
Marie-Josée Fleury, Zhirong Cao, Guy Grenier
INTRODUCTION: Patients with mental health diagnoses (MHD) are among the most frequent emergency department (ED) users, suggesting the importance of identifying additional factors associated with their ED use frequency. In this study we assessed various patient sociodemographic and clinical characteristics, and service use associated with low ED users (1-3 visits/year), compared to high (4-7) and very high (8+) ED users with MHD. METHODS: Our study was conducted in four large Quebec (Canada) ED networks...
March 2024: Western Journal of Emergency Medicine
#39
JOURNAL ARTICLE
Lucy Hyam, Olivia Yeadon-Ray, Katie Richards, Amy Semple, Karina Allen, Jill Owens, Aileen Jackson, Laura Semple, Danielle Glennon, Giulia Di Clemente, Jess Griffiths, Regan Mills, Ulrike Schmidt
INTRODUCTION: First Episode Rapid Early Intervention for Eating Disorders (FREED) is the leading eating disorder (ED) early intervention model for young people. Research has shown that it reduces the duration of untreated illness, improves clinical outcomes, and has cost savings. However, less is known about the experience of implementing FREED. This study aimed to investigate the views and experiences of adopting, implementing, and sustaining FREED from the perspective of clinical staff...
2024: Frontiers in Psychiatry
#40
REVIEW
Namrata Dagli, Mainul Haque, Santosh Kumar
Stress is ubiquitous in modern life, influencing various facets of human health and well-being. While the impact of stress on mental and physical health is well-documented, its effects on oral health have garnered increasing attention in recent years. This bibliometric analysis explores the literature on the impact of stress on oral health. The study utilizes data from the PubMed database, focusing on publication trends, influential contributors and the temporal analysis of their publications, coauthorship analysis of authors and institutions, key thematic clusters, thematic evolution, and collaboration between various countries...
April 2024: Curēus
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