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https://www.readbyqxmd.com/read/29792909/dermatofibrosarcoma-protuberans-a-retrospective-study-of-clinicopathological-features-and-related-akt-mtor-stat3-erk-cyclin-d1-and-pd-l1-expression
#1
Sunyoung Park, Soyun Cho, Minji Kim, Ji Ung Park, Eui Cheol Jeong, Euno Choi, Jeong Hwan Park, Cheol Lee, Mee Soo Chang
BACKGROUND: Little is known regarding oncoproteins other than PDGFβ in dermatofibrosarcoma protuberance (DFSP). Moreover, the risk factors for worse prognosis are controversial. OBJECTIVE: We sought to determine the clinicopathological features and key factors for adverse outcome in DFSP including the implication of Akt/mTOR, STAT3, ERK, cyclinD1, and PD-L1 expression. METHODS: Clinicopathological and immunohistochemical analyses were performed for 44 DFSPs having wide local excision along with 92 dermatofibromas as controls...
May 21, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29792851/collagen-induced-arthritis-in-dark-agouti-rats-as-a-model-for-study-of-immunological-sexual-dimorphisms-in-the-human-disease
#2
Mirjana Dimitrijević, Nevena Arsenović-Ranin, Biljana Bufan, Mirjana Nacka-Aleksić, Mirjana Lazarević Macanović, Petar Milovanović, Marija Đurić, Jelena Sopta, Gordana Leposavić
Collagen-induced arthritis (CIA) is a frequently used animal model of rheumatoid arthritis, human autoimmune disease that exhibits clear sex bias in incidence and clinical course. Female Dark Agouti rats immunized for CIA showed also greater incidence and higher arthritic score than their male counterparts. The study investigated sex differences in mechanisms controlling the primary immune responses in draining lymph nodes (dLNs), as a factor contributing to this dimorphism. The higher frequencies of CD4 + CD25 + Foxp3- cells, presumably activated effector T (Teff) cells, and IL-17+, IFN-γ + and IL-17 + IFN-γ + T cells were found in female comapared with male rat dLNs...
May 21, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29792848/subthalamic-nucleus-deep-brain-stimulation-protects-neurons-by-activating-autophagy-via-pp2a-inactivation-in-a-rat-model-of-parkinson-s-disease
#3
Ting-Ting Du, Ying-Chuan Chen, Yong-Quan Lu, Fan-Gang Meng, Hui Yang, Jian-Guo Zhang
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapeutic strategy for alleviating disability in patients with moderate to severe Parkinson's disease (PD). Preclinical studies have shown that stimulation of the rat STN can protect against nigral dopaminergic neuron loss. However, the underlying mechanism is unclear. To investigate the molecular basis of the neuroprotective effects of STN stimulation, a rat model of PD was established by unilaterally injecting 6-hydroxydopamine (6-OHDA) into the striatum...
May 21, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29792705/total-synthesis-of-boletopsin-11-enabled-by-directed-ortho-c-sp-2-h-arylation
#4
Meng Yao Zhang, Russell A Barrow
A nine-step synthesis of boletopsin 11 (1), a bioactive fungal natural product, is disclosed. Key features include a one-pot [O]-oxa-Michael cascade to establish the polyoxygenated dibenzofuran core followed by a Pd-catalyzed directed ortho-C(sp2 )-H arylation to complete the fully functionalized carbon skeleton. Exploration of the latter transformation led to the discovery of an unexpected tandem ortho-C(sp2 )-H arylation event, and the scope of the directed ortho-C(sp2 )-H reaction was further investigated with coupling partners varying in stereoelectronic properties...
May 24, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29792695/bond-dissociation-energies-of-metallo-supramolecular-building-blocks-insight-from-fragmentation-of-selectively-self-assembled-heterometallic-metallo-supramolecular-aggregates
#5
Yvonne Lorenz, Albert Gutiérrez, Montserrat Ferrer, Marianne Engeser
A series of selectively self-assembled metallo-supramolecular square-like macrocycles with unsymmetric ditopic linkers and two different types of metal corners, i.e., {Pd(η3 -2-Me-C3 H4 )} and {M(dppp)} with dppp = 1,3-bis(diphenylphosphino)propane and M = Pd2+ or Pt2+ , have been studied in the gas phase using collision-induced dissociation. The aggregates show distinct fragmentation patterns determined by ligand length, i.e, aggregate size, and type of metal corner. Information on relative binding strength can be deduced...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792667/control-of-selectivity-in-palladium-ii-catalyzed-oxidative-transformations-of-allenes
#6
Bin Yang, Youai Qiu, Jan-E Bäckvall
Oxidation reactions play a central role in organic synthesis, and it is highly desirable that these reactions are mild and occur under catalytic conditions. In Nature, oxidation reactions occur under mild conditions via cascade processes, and furthermore, they often occur in an enantioselective manner with many of them involving molecular oxygen or hydrogen peroxide as the terminal oxidant. Inspired by the reactions in Nature, we have developed a number of Pd(II)-catalyzed cascade reactions under mild oxidative conditions...
May 24, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29792418/self-assembled-pd-ii-6-molecular-spheroids-and-their-proton-conduction-property
#7
Rupak Saha, Aloke Kumar Ghosh, Rudra Narayan Samajdar, Partha Sarathi Mukherjee
A series of molecular spheroids (SP1-SP4) was synthesized using pseudolinear bisimidazole and bisbenzimidazole donors in combination with Pd(NO3 )2 acceptor via coordination-driven self-assembly. They were characterized by NMR and mass spectrometry, and the solid-state structures of SP1 and SP3 were confirmed by X-ray diffraction. Crystal packing revealed the presence of molecular channels with water molecules in the channels as proton source. All the systems showed proton conductivity across a wide range of temperature and relative humidity...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792332/ligation-enhanced-%C3%AF-hole%C3%A2-%C3%A2-%C3%A2-%C3%AF-interactions-involving-isocyanides-effect-of-%C3%AF-hole%C3%A2-%C3%A2-%C3%A2-%C3%AF-noncovalent-bonding-on-conformational-stabilization-of-acyclic-diaminocarbene-ligands
#8
Alexander S Mikherdov, Mikhail A Kinzhalov, Alexander S Novikov, Vadim P Boyarskiy, Irina A Boyarskaya, Margarita S Avdontceva, Vadim Yu Kukushkin
The reaction of cis-[PdCl2 (CNXyl)2 ] (Xyl = 2,6-Me2 C6 H3 ) with the aminoazoles [1 H-imidazol-2-amine (1), 4 H-1,2,4-triazol-3-amine (2), 1 H-tetrazol-5-amine (3), 1 H-benzimidazol-2-amine (4), 1-alkyl-1 H-benzimidazol-2-amines, where alkyl = Me (5), Et (6)] in a 2:1 ratio in the presence of a base in CHCl3 at RT proceeds regioselectively and leads to the binuclear diaminocarbene complexes [(ClPdCNXyl)2 {μ-C(N-azolyl)N(Xyl)C═NXyl}] (7-12; 73-91%). Compounds 7-12 were characterized by C, H, N elemental analyses, high-resolution ESI+ -MS, Fourier transform infrared spectroscopy, 1D (1 H, 13 C) and 2D (1 H,1 H-COSY, 1 H,1 H-NOESY, 1 H,13 C-HSQC, 1 H,13 C-HMBC) NMR spectroscopies, and X-ray diffraction (XRDn)...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792163/different-patterns-of-inflammatory-and-angiogenic-factors-are-associated-with-peritoneal-small-solute-transport-and-peritoneal-protein-clearance-in-peritoneal-dialysis-patients
#9
Yuanyuan Shi, Hao Yan, Jiangzi Yuan, He Zhang, Jiaying Huang, Zhaohui Ni, Jiaqi Qian, Wei Fang
BACKGROUND: Both peritoneal small solute transport and peritoneal protein clearance are closely linked to outcomes in peritoneal dialysis (PD) patients. However, the associated factors of these two components are not fully understood so far. This study aimed to investigate the association between a panel of systemic and peritoneal inflammatory and angiogenic factors and peritoneal solute transport properties. METHODS: Stable PD patients in PD center of Renji Hospital, School of Medicine, Shanghai Jiao Tong University were enrolled in present study...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29791971/predictors-of-treatment-success-after-collagenase-clostridium-histolyticum-injection-for-peyronie-s-disease-development-of-a-nomogram-from-a-multicentre-single-arm-non-placebo-controlled-clinical-study
#10
Andrea Cocci, Giorgio Ivan Russo, Alberto Briganti, Andrea Salonia, Giovanni Cacciamani, Marco Capece, Marco Falcone, Massimiliano Timpano, Gianmartin Cito, Paolo Verze, Bruno Giammusso, Giuseppe Morgia, Vincenzo Mirone, Andrea Minervini, Mauro Gacci, Tommaso Cai, Sergio Serni, Marco Carini, Gianluca Giubilei, Nicola Mondaini
OBJECTIVE: To build-up a nomogram able to predict treatment success after Collagenase clostridium histolyticum (CCH) for Peyronie's disease (PD). MATERIAL AND METHODS: From November 2016 to November 2017, we enrolled 135 patients with PD in a multicentre single-arm prospective study. All patients enrolled had a treatment with CCH. Success of therapy was defined as a penile curvature decrease of at least 20 degrees from baseline curvature. Treatment satisfaction was assessed using a scale from 1 to 10 and high satisfaction was arbitral defined as a score ≥8...
May 23, 2018: BJU International
https://www.readbyqxmd.com/read/29791914/atlas-independent-electrophysiological-mapping-of-the-optimal-locus-of-subthalamic-deep-brain-stimulation-for-the-motor-symptoms-of-parkinson-disease
#11
Erin C Conrad, James M Mossner, Kelvin L Chou, Parag G Patil
BACKGROUND/AIMS: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms of Parkinson disease (PD). However, motor outcomes can be variable, perhaps due to inconsistent positioning of the active contact relative to an unknown optimal locus of stimulation. Here, we determine the optimal locus of STN stimulation in a geometrically unconstrained, mathematically precise, and atlas-independent manner, using Unified Parkinson Disease Rating Scale (UPDRS) motor outcomes and an electrophysiological neuronal stimulation model...
May 23, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29791900/re-operative-pancreaticoduodenectomy-challenges-and-outcomes
#12
Manish S Bhandare, Nikhil Mehta, Vikram Chaudhari, Naveena An Kumar, Esha Pai, Mahesh Goel, Shailesh V Shrikhande
BACKGROUND: Tata Memorial Centre (TMC) is a high-volume centre for pancreatic tumour resections. We found a continually increasing referral of pancreatic tumours for re-evaluation for surgery, after an initial unsuccessful attempt at resection. AIM: To evaluate reasons of initial in-operability, the feasibility of re-operative pancreatico-duodenectomy (R-PD) and short- and long-term outcomes after R-PD. METHODS: Data was collected from a prospective database of GI and hepato-pancreato-biliary service, TMC, Mumbai from January 2008 to December 2016...
May 23, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29791768/vaccine-immunotherapy-with-arnax-induces-tumor-specific-memory-t-cells-and-durable-anti-tumor-immunity-in-mouse-models
#13
Yohei Takeda, Sumito Yoshida, Ken Takashima, Noriko Ishii-Mugikura, Hiroaki Shime, Tsukasa Seya, Misako Matsumoto
Immunological checkpoint blockade therapies benefit a limited population of cancer patients. We have previously shown that vaccine immunotherapy with TLR3-adjuvant and tumor antigen overcomes anti-programmed death ligand-1 (PD-L1) resistance in mouse tumor models. In this study, four different OVA-expressing tumor cell lines were implanted into syngeneic mice and subjected to antitumor immunotherapy using ARNAX and whole OVA protein. ARNAX is a Toll-like receptor 3-specific agonist that does not activate the MAVS pathway, and thus does not induce systemic inflammation...
May 23, 2018: Cancer Science
https://www.readbyqxmd.com/read/29791618/performance-of-children-with-speech-sound-disorders-in-the-dynamic-evaluation-of-motor-speech-skills
#14
Marcia Keske-Soares, Letícia Bitencourt Uberti, Marieli Barichello Gubiani, Marileda Barichello Gubiani, Marizete Ilha Ceron, Karina Carlesso Pagliarin
Purpose To compare performance between children with typical speech acquisition, phonological disorders, and childhood apraxia of speech for the variables overall articulatory accuracy and consistency of the Dynamic Evaluation of Motor Speech Skill - Brazilian Portuguese version (DEMSS-BR). Methods Study participants were 18 children of both genders aged 4 years and 6 months to 5 years and 8 months. The sample was divided into three groups: six children with typical speech acquisition (TSA), six children with phonological disorder (PD), and six individuals with childhood apraxia of speech (CAS)...
2018: CoDAS
https://www.readbyqxmd.com/read/29791274/cathodal-tdcs-of-the-left-posterior-parietal-cortex-increases-proprioceptive-drift
#15
João Roberto Ventura de Oliveira, Marco Aurélio Romano-Silva, Herbert Ugrinowitsch, Tércio Apolinário-Souza, Lidiane Aparecida Fernandes, Juliana Otoni Parma, Guilherme Menezes Lage
In aiming movements the limb position drifts away from the defined target after some trials without visual feedback, a phenomenon defined as proprioceptive drift (PD). There are no studies investigating the association between the posterior parietal cortex (PPC) and PD in aiming movements. Therefore, cathodal and sham transcranial direct current stimulation (tDCS) were applied to the left PPC concomitantly with the performance of movements with or without vision. Cathodal tDCS applied without vision produced a higher level of PD and higher rates of drift accumulation while it decreased peak velocity and maintained the number of error corrections, not affecting movement amplitude...
May 23, 2018: Journal of Motor Behavior
https://www.readbyqxmd.com/read/29791029/development-of-a-3d-ultrasound-guidance-system-for-permanent-breast-seed-implantation
#16
Justin Michael, Daniel Morton, Deidre Batchelar, Michelle Hilts, Juanita Crook, Aaron Fenster
PURPOSE: Permanent breast seed implantation (PBSI) is a promising radiotherapy technique for early-stage breast cancer, completed in a single visit by permanently implanting 103 Pd seeds using needles inserted through a template and guided by 2D ultrasound (US). However, operator dependence has been highlighted as a limitation of this procedure. Consequently, we propose and have developed an intraoperative guidance system using 3D US and an instrumented mechanical arm to provide intraoperative 3D imaging and needle template tracking...
May 23, 2018: Medical Physics
https://www.readbyqxmd.com/read/29791021/immtac-anti-pd-1-combination-to-enhance-killing-of-cancer-cells-by-reversing-treg-mediated-immunosuppression
#17
Huanling Zhang, Yanyan Li, Xiaoping Liu, Zhaoduan Liang, Mengyong Yan, Qiang Liu, Anan Chen, Yifeng Bao, Chengzhi Zhou, Shiyue Li, Cassian Yee, Yi Li
Recently, bi-functional molecules that can redirect immune effectors to tumor cells have emerged as potentially robust mediators of tumor regression in clinical trials. Two modalities, in particular, bi-specific antibodies for T cell redirection and activation (BiTe) and immune-mobilizing monoclonal T-cell receptors against cancer (ImmTAC) are being evaluated in efficacy studies as 'off-the-shelf' reagents. Optimal therapy will require an understanding and means to address regulatory mechanisms of limiting efficacy...
May 23, 2018: Immunology
https://www.readbyqxmd.com/read/29790977/alpha-synuclein-aggregates-in-labial-salivary-glands-of-idiopathic-rapid-eye-movement-sleep-behavior-disorder
#18
Alx Iranzo, Sergi Borrego, Isabel Vilaseca, Carles Martí, Mónica Serradell, Raquel Sánchez-Valle, Gabor G Kovacs, Francesc Valldeoriola, Carles Gaig, Joan Santamaria, Eduard Tolosa, Ellen Gelpi
Study Objectives : To assess whether biopsy of the labial minor salivary glands safely detects phosphorylated alpha-synuclein (pAS) deposits in idiopathic REM sleep behavior disorder (IRBD), a condition that precedes the cardinal manifestations of synuclein disorders associated with Lewy type pathology, namely Parkinson disease (PD) and dementia with Lewy bodies (DLB). Methods: In a prospective study, labial biopsy of the minor salivary glands was performed in 62 IRBD patients, 13 PD and 10 DLB patients who were initially diagnosed with IRBD, and in 33 controls...
May 22, 2018: Sleep
https://www.readbyqxmd.com/read/29790935/intake-and-feed-utilization-in-two-breeds-of-pregnant-beef-cows-fed-forages-with-high-fiber-concentrations
#19
M Jardstedt, A Hessle, P Nørgaard, L Frendberg, E Nadeau
Hereford and Charolais beef cows (n = 24 per breed) were used to study the effect of breed and to evaluate how late cut reed canarygrass (RC) and whole-crop oats plus urea (WCO) compared to late cut timothy (TG) with respect to feed intake and digestibility, rumination time, fecal particle size (PS) distribution, N excretion, and ruminal microbial CP production (MCP). The TG and RC were cut at flowering and WCO at hard dough stage of maturity. Cows were group-housed, six groups per breed, and fed the three diets ad libitum in three periods...
May 22, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29790734/palladium-supported-on-amphiphilic-triazine-urea-functionalized-porous-organic-polymer-as-highly-efficient-electrocatalyst-for-electrochemical-sensing-of-rutin-in-human-plasma
#20
A T Ezhil Vilian, Rajamanickam Sivakumar, Yun Suk Huh, Ji Ho Youk, Young-Kyu Han
Metal nanoparticle-containing porous organic polymers have gained great interest in chemical and pharmaceutical applications owing to their high reactivity and good recyclability. In the present work, a palladium nanoparticle-decorated triazine-urea-based porous organic polymer (Pd@TU-POP) was designed and synthesized using 1, 3-bis (4-aminiphenyl) urea with cyanuric chloride and palladium acetate. The porous structure and physicochemical properties of this electrode material Pd@TU-POP were observed using a range of standard techniques...
May 23, 2018: ACS Applied Materials & Interfaces
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