keyword
https://read.qxmd.com/read/38475166/frequency-resolved-high-frequency-broadband-measurement-of-acoustic-longitudinal-waves-by-laser-based-excitation-and-detection
#21
JOURNAL ARTICLE
Felix Brand, Klaus Stefan Drese
Optoacoustics is a metrology widely used for material characterisation. In this study, a measurement setup for the selective determination of the frequency-resolved phase velocities and attenuations of longitudinal waves over a wide frequency range (3-55 MHz) is presented. The ultrasonic waves in this setup were excited by a pulsed laser within an absorption layer in the thermoelastic regime and directed through a layer of water onto a sample. The acoustic waves were detected using a self-built adaptive interferometer with a photorefractive crystal...
March 1, 2024: Sensors
https://read.qxmd.com/read/38475156/evaluation-of-pipe-thickness-by-magnetic-hammer-test-with-a-tunnel-magnetoresistive-sensor
#22
JOURNAL ARTICLE
Jun Ito, Yudai Igarashi, Ryota Odagiri, Shigetaka Suzuki, Hiroshi Wagatsuma, Kazuhiro Sugiyama, Mikihiko Oogane
A new nondestructive inspection method, the magnetic hammer test (MHT), which uses a compact and highly sensitive tunnel magnetoresistance (TMR) sensor, is proposed. This method complements the magnetic flux leakage method and eliminates the issues of the hammer test. It can therefore detect weak magnetic fields generated by the natural vibration of a pipe with a high signal-to-noise ratio. In this study, several steel pipes with different wall thicknesses were measured using a TMR sensor to demonstrate the superiority of MHT...
March 1, 2024: Sensors
https://read.qxmd.com/read/38474957/phased-array-ultrasonic-method-for-robotic-preload-measurement-in-offshore-wind-turbine-bolted-connections
#23
JOURNAL ARTICLE
Yashar Javadi, Brandon Mills, Charles MacLeod, David Lines, Farhad Abad, Saeid Lotfian, Ali Mehmanparast, Gareth Pierce, Feargal Brennan, Anthony Gachagan, Carmelo Mineo
This paper presents a novel approach for preload measurement of bolted connections, specifically tailored for offshore wind applications. The proposed method combines robotics, Phased Array Ultrasonic Testing (PAUT), nonlinear acoustoelasticity, and Finite Element Analysis (FEA). Acceptable defects, below a pre-defined size, are shown to have an impact on preload measurement, and therefore conducting simultaneous defect detection and preload measurement is discussed in this paper. The study demonstrates that even slight changes in the orientation of the ultrasonic transducer, the non-automated approach, can introduce a significant error of up to 140 MPa in bolt stress measurement and therefore a robotic approach is employed to achieve consistent and accurate measurements...
February 22, 2024: Sensors
https://read.qxmd.com/read/38473642/damage-detection-in-frp-reinforced-concrete-elements
#24
JOURNAL ARTICLE
Pranit Malla, Seyed Saman Khedmatgozar Dolati, Jesus D Ortiz, Armin B Mehrabi, Antonio Nanni, Jiayi Ding
Fiber-Reinforced Polymer (FRP) composites have emerged as a promising alternative to conventional steel reinforcements in concrete structures owing to their benefits of corrosion resistance, higher strength-to-weight ratio, reduced maintenance cost, extended service life, and superior durability. However, there has been limited research on non-destructive testing (NDT) methods applicable for identifying damage in FRP-reinforced concrete (FRP-RC) elements. This knowledge gap has often limited its application in the construction industry...
March 2, 2024: Materials
https://read.qxmd.com/read/38473444/pathways-toward-the-use-of-non-destructive-micromagnetic-analysis-for-porosity-assessment-and-process-parameter-optimization-in-additive-manufacturing-of-42crmo4-aisi-4140
#25
JOURNAL ARTICLE
Anna Engelhardt, Thomas Wegener, Thomas Niendorf
Laser-based powder bed fusion of metals (PBF-LB/M) is a widely applied additive manufacturing technique. Thus, PBF-LB/M represents a potential candidate for the processing of quenched and tempered (Q&T) steels such as 42CrMo4 (AISI 4140), as these steels are often considered as the material of choice for complex components, e.g., in the toolmaking industry. However, due to the presence of process-induced defects, achieving a high quality of the resulting parts remains challenging in PBF-LB/M. Therefore, an extensive quality inspection, e...
February 20, 2024: Materials
https://read.qxmd.com/read/38469210/4-hydroxysesamin-a-modified-natural-compound-attenuates-neuronal-apoptosis-after-ischemic-stroke-via-inhibiting-mapk-pathway
#26
JOURNAL ARTICLE
Lina Wang, Zhenzhen Qu, Qian Sun, Zhuofeng Mao, Peipei Si, Weiping Wang
BACKGROUND: The 4-hydroxysesamin (4-HS, a di-tetrahydrofuran lignin) is a modified sesamin that was prepared in the laboratory. This preclinical study was designed to preliminarily investigate the neuroprotective properties of 4-HS. METHODS: In vitro, neuronal injury and inflammation were simulated by oxygen-glucose deprivation and lipopolysaccharide (LPS) exposure in mouse hippocampal neuronal HT22 cell line, and treated with 4-HS and/or metformin (MET, MAPK pathway activator for exploring mechanism)...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38469209/effects-of-aripiprazole-on-olanzapine-population-pharmacokinetics-and-initial-dosage-optimization-in-schizophrenia-patients
#27
JOURNAL ARTICLE
Cun Zhang, Lei Jiang, Ke Hu, Liang Chen, Yi-Jia Zhang, Hao-Zhe Shi, Su-Mei He, Xiao Chen, Dong-Dong Wang
OBJECTIVE: Olanzapine has already been used to treat schizophrenia patients; however, the initial dosage recommendation when multiple drugs are used in combination, remains unclear. The purpose of this study was to explore the drug-drug interaction (DDI) of multiple drugs combined with olanzapine and to recommend the optimal administration of olanzapine in schizophrenia patients. METHODS: In this study, we obtained olanzapine concentrations from therapeutic drug monitoring (TDM) database...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38469208/improving-diagnostic-procedures-in-autism-for-girls-and-women-a-narrative-review
#28
REVIEW
Julia Cook, Laura Hull, Will Mandy
Biases exist in the diagnostic process for autism spectrum disorder (henceforth "autism"), which result in some girls and women being diagnosed later or missed entirely. Current diagnostic tools may not capture the full range of behavioural presentations of autism, leading to under-identification. This review explores why these biases may occur, and how diagnostic procedures could be adapted to better identify autistic girls and women. We recommend that diagnostic assessments are adjusted to capture a broader range of behavioural exemplars of autism; that camouflaging of autistic traits is taken into account; and that care is taken to ensure co-occurring mental health conditions do not overshadow autism diagnosis...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38469207/the-impact-of-recent-life-events-internalizing-symptoms-and-emotion-regulation-on-the-severity-of-non-suicidal-self-injury-in-adolescents-a-mediation-analysis
#29
JOURNAL ARTICLE
Linqi Zhou, Changyuan Qiao, Jialing Huang, Jian Lin, Haisheng Zhang, Jian Xie, Yonggui Yuan, Changchun Hu
BACKGROUND: Previous studies have demonstrated a strong association between recent stressful life events and non-suicidal self-injury (NSSI) among adolescents. Internalizing symptoms and difficulty in emotion regulation (DER) may mediate this relationship. This study aimed to investigate the relationship between recent stressful life events and NSSI severity in adolescents and the potential moderating role of internalizing symptoms and DER. METHODS: A total of 224 adolescent inpatients (78...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38469206/clinical-characteristics-of-asymptomatic-thromboembolism-in-psychiatric-inpatients-a-retrospective-study
#30
JOURNAL ARTICLE
Yimeng Geng, Peifen Zhang, Yanmeng Pan, Huaizhi Wang, Yi Chen, Jianbo Lai, Shaohua Hu
PURPOSE: Venous thromboembolism (VTE) poses a significant threat to individuals' health, yet its correlation with mental disorders remains underappreciated. Here, we conducted a retrospective analysis to explore the characteristics of psychiatric patients presenting with VTE. METHODS: We retrospectively analyzed psychiatric inpatients with elevated plasma D-dimer levels at the Mental Health Center, First Affiliated Hospital, Zhejiang University School of Medicine, from January 2014 to January 2022...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38469000/a-case-report-can-prioritizing-sensory-integration-therapy-help-improve-gross-motor-function-in-a-rare-case-of-neurogenic-arthrogryposis-multiplex-congenita
#31
Nikita Sawant, Asmita Karajgi
Arthrogryposis multiplex congenital (AMC) is a congenital disorder diagnosed with extremity contractures, restricted joint range of motion, foot abnormalities, and hip dislocation. The current literature emphasizes medical and surgical management, but very few studies provide insight into physiotherapy management for AMC. We reported the case of a 16-month-old male diagnosed with AMC, operated on both hips for teratologic dislocation. Physiotherapy examination was conducted, and treatment was planned based on the principles of Sensory Integration Therapy (SIT) and neurodevelopmental technique (NDT) with orthosis to assist in functional recovery...
February 2024: Curēus
https://read.qxmd.com/read/38463459/clinical-analysis-of-lacosamide-monotherapy-in-the-treatment-of-self-limited-epilepsy-with-centrotemporal-spikes
#32
JOURNAL ARTICLE
Jun Feng, Liya Zhang, Jihong Tang, Bingbing Zhang, Xiao Xiao, Xiaoyan Shi
OBJECTIVE: To evaluate the efficacy and safety of lacosamide (LCM) monotherapy in the treatment of self-limited epilepsy with centrotemporal spikes (SeLECTS). METHODS: In this study, 89 children with SeLECTS who were treated with LCM monotherapy in the Children's Hospital Affiliated to Soochow University from June 2019 to June 2021 were included. Clinical seizures and spike wave index (SWI) on video EEG during slow-wave sleep were evaluated before and after treatment...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38463458/erratum-validation-and-functional-relevance-of-the-short-form-of-the-perceived-deficits-questionnaire-for-depression-for-japanese-patients-with-major-depressive-disorder-corrigendum
#33
(no author information available yet)
[This corrects the article DOI: 10.2147/NDT.S381647.].
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38463457/severe-refractory-obsessive-compulsive-disorder-and-depression-should-we-consider-stereotactic-neurosurgery
#34
JOURNAL ARTICLE
Ludvic Zrinzo
Functional neurosurgery involves modulation of activity within neural circuits that drive pathological activity. Neurologists and neurosurgeons have worked closely together, advancing the field for over a century, such that neurosurgical procedures for movement disorders are now accepted as "standard of care", benefiting hundreds of thousands of patients. As with movement disorders, some neuropsychiatric illnesses, including obsessive compulsive disorder and depression, can be framed as disorders of neural networks...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38460949/sex-differences-in-cancer-outcomes-across-the-range-of-egfr
#35
JOURNAL ARTICLE
Richard Shemilt, Michael K Sullivan, Peter Hanlon, Bhautesh Jani, Nicole De La Mata, Brenda Rosales, Benjamin M P Elyan, James A Hedley, Rachel B Cutting, Melanie Wyld, David A McAllister, Angela C Webster, Patrick B Mark, Jennifer S Lees
BACKGROUND AND HYPOTHESIS: People with chronic kidney disease (CKD) have increased incidence and mortality from most cancer types. We hypothesised that odds of presenting with advanced cancer may vary according to differences in eGFR, that this could contribute to increased all-cause mortality and that sex differences may exist. METHODS: Data were from Secure Anonymised Information Linkage Databank, including people with de-novo cancer diagnosis (2011-2017) and two kidney function tests within two years prior to diagnosis to determine baseline eGFR (mL/min/1...
March 9, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38460948/physical-exercise-a-polypill-against-chronic-kidney-disease
#36
JOURNAL ARTICLE
Pedro L Valenzuela, Adrián Castillo-García, Gonzalo Saco-Ledo, Alejandro Santos-Lozano, Alejandro Lucia
We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise intervention in affected patients. Physical activity/exercise might act as a polypill against CKD, preventing its development or even exerting beneficial effects once it is established (i.e. improvements in patients' physical fitness and cardiovascular risk, as well as in kidney function)...
March 9, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38453435/efficacy-tolerability-and-safety-of-the-oral-phosphate-binder-vs-505-ap301
#37
JOURNAL ARTICLE
Bing Zhuang, Liangying Gan, Bin Liu, Weijie Yuan, Ming Shi, Ai Peng, Lihua Wang, Xiaolan Chen, Tongqiang Liu, Shiying Zhang, Song Wang, Qing Gao, Baoxing Wang, Huixiao Zheng, Changhua Liu, Yuan Luo, Hong Ye, Hongli Lin, Yiwen Li, Qiang He, Feng Zheng, Ping Luo, Gang Long, Wei Lu, Kanghui Li, Junwei Yang, Yingxue Cathy Liu, Zhizheng Zhang, Xiaolin Li, Weifeng Zhang, Li Zuo
BACKGROUND: VS-505 (AP301), an acacia and ferric oxyhydroxide polymer, is a novel fiber-iron-based phosphate binder. This two-part phase 2 study evaluated the tolerability, safety, and efficacy of oral VS-505 administered three times daily with meals in treating hyperphosphatemia in chronic kidney disease (CKD) patients receiving maintenance hemodialysis (MHD). METHODS: In Part 1, patients received dose-escalated treatment with VS-505 2.25, 4.50, and 9.00 g/day for 2 weeks each, guided by serum phosphorus levels...
March 7, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38449528/snapshots-of-the-reaction-coordinate-of-a-thermophilic-2-deoxyribonucleoside-ribonucleoside-transferase
#38
JOURNAL ARTICLE
Peijun Tang, Christopher J Harding, Alison L Dickson, Rafael G da Silva, David J Harrison, Clarissa Melo Czekster
Nucleosides are ubiquitous to life and are required for the synthesis of DNA, RNA, and other molecules crucial for cell survival. Despite the notoriously difficult organic synthesis of nucleosides, 2'-deoxynucleoside analogues can interfere with natural DNA replication and repair and are successfully employed as anticancer, antiviral, and antimicrobial compounds. Nucleoside 2'-deoxyribosyltransferase (dNDT) enzymes catalyze transglycosylation via a covalent 2'-deoxyribosylated enzyme intermediate with retention of configuration, having applications in the biocatalytic synthesis of 2'-deoxynucleoside analogues in a single step...
March 1, 2024: ACS Catalysis
https://read.qxmd.com/read/38444996/validity-and-reliability-study-of-the-turkish-version-of-the-orbach-mikulincer-mental-pain-scale-8-in-a-clinical-population
#39
JOURNAL ARTICLE
Mehmet Emin Demirkol, Lut Tamam, Zeynep Namlı, Caner Yeşiloğlu, Hamdi Yılmaz
PURPOSE: Suicide is a growing public health issue for all societies; identifying suicide risk is crucial. This study aims to evaluate the psychometric properties of the Turkish version of the Orbach and Mikulincer Mental Pain Scale-8 (OMMP-8), which enables the assessment of suicidality in a short time. PATIENTS AND METHODS: We conducted this study with 148 individuals diagnosed with major depressive disorder and 130 healthy controls. We administered the Hamilton Depression Scale (HDRS), Beck Hopelessness Scale (BHS), Beck Scale for Suicidal Ideation (BSIS), and Mee Bunney Psychological Pain Assessment Scale (MBPPAS) to all participants...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38444995/prognostic-significance-of-uric-acid-levels-in-intracerebral-hemorrhage-patients
#40
JOURNAL ARTICLE
Wenpei Wu, Zhi Geng, Aimei Wu, Xinyi Chen, Xiaoying Meng, Qianyun Zhang, Zheng Tan, Hong Yue, Juncang Wu
BACKGROUND AND PURPOSE: The role of serum uric acid (UA) level in patients suffering from stroke remains controversial. Our aim was to investigate the effect of UA level on clinical outcomes in patients with intracerebral hemorrhage (ICH). METHODS: In the retrospective cohort study, we analyzed data from 250 patients with intracerebral hemorrhage (85 women and 165 men) to investigate the difference in UA levels between patients with a good prognosis and those with a poor prognosis...
2024: Neuropsychiatric Disease and Treatment
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