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Lara Wahlberg, Anita Nirenberg, Elizabeth Capezuti
PURPOSE/OBJECTIVES: To examine distress and coping self-efficacy in inpatient oncology nurses. 
. DESIGN: Cross-sectional survey design.
. SETTING: Oncology Nursing Society (ONS) chapter meetings and Hunter-Bellevue School of Nursing, both in New York, New York, as well as social media.
. SAMPLE: 163 oncology nurses who work with an inpatient adult population.
. METHODS: Participants were recruited through the ONS New York, New York, area chapter meetings, Hunter College, and ONS Facebook pages...
November 1, 2016: Oncology Nursing Forum
A Kenneth MacLeod, Lesley A McLaughlin, Colin J Henderson, C Roland Wolf
Tamoxifen is an oestrogen-receptor (ER) antagonist used in the treatment of breast cancer. It is a pro-drug, converted by several P450 enzymes to a primary metabolite, N-desmethyltamoxifen (NDT), which is then further modified by CYP2D6 to a pharmacologically potent secondary metabolite, 4-hydroxy-N-desmethyltamoxifen (endoxifen). Anti-depressants (ADs), which are often co-prescribed to patients receiving tamoxifen, are also metabolised by CYP2D6 and evidence suggests that a drug-drug interaction (DDI) between these agents adversely affects the outcome of tamoxifen therapy by inhibiting endoxifen formation...
October 18, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Navnina Bhatia, David Tisseur, Solene Valton, Jean Michel Létang
Due to the increased cone beam coverage and the introduction of flat panel detector, the size of X-ray illumination fields has grown dramatically in Cone Beam Computed Tomography (CBCT), causing an increase in scatter radiation. Existing reconstruction algorithms do not model the scatter radiation, so scatter artifacts appear in the reconstruction images. The contribution of scattering of photons inside the detector itself becomes prominent and challenging in case of X-ray source of high energy (over a few 100 keV) which is used in typical industrial Non Destructive Testing (NDT)...
October 6, 2016: Journal of X-ray Science and Technology
Marco Tramontano, Alessandra Medici, Marco Iosa, Alessia Chiariotti, Giulia Fusillo, Leonardo Manzari, Daniela Morelli
BACKGROUND: Cerebral palsy (CP) has been defined as a non-progressive disease of movement and posture development. Physical therapy techniques use different forms of sensory stimulation to improve neuromotor development. AIM: The aim of this study was to assess the efficacy of a vestibular stimulation training in improving motor functions in cerebral palsy. POPULATION: Fourteen children with CP were randomly separated into two different groups in a cross-over trial...
August 19, 2016: Motor Control
Jonathan Adam, Stefan Brandmaier, Jörn Leonhardt, Markus F Scheerer, Robert P Mohney, Tao Xu, Jie Bi, Markus Rotter, Martina Troll, Shen Chi, Margit Heier, Christian Herder, Wolfgang Rathmann, Guido Giani, Jerzy Adamski, Thomas Illig, Konstantin Strauch, Yixue Li, Christian Gieger, Annette Peters, Karsten Suhre, Donna Ankerst, Thomas Meitinger, Martin Hrabe de Angelis, Michael Roden, Susanne Neschen, Gabi Kastenmüller, Rui Wang-Sattler
Metformin is the first-line oral medication to increase insulin sensitivity in patients with type 2 diabetes (T2D). Our aim is to investigate metformin's pleiotropic effect using a non-targeted metabolomics approach. We analyzed 353 metabolites in fasting serum samples of the population-based human KORA F4 cohort. To compare T2D patients treated with metformin (mt-T2D, n=74) and those without antidiabetic medication (ndt-T2D, n=115), we used multivariable linear regression models in a cross-sectional study...
September 12, 2016: Diabetes
Voyko Kavcic, Bojan Zalar, Bruno Giordani
The finding that some older individuals report declines in aspects of cognitive functioning is becoming a frequently used criteria to identify elderly at risk for mild cognitive impairment (MCI) and dementia. Once concerns are identified in a community setting, however, effective means are necessary to pinpoint those individuals who should go on to more complex and costly diagnostic evaluations (e.g., functional imaging). We tested 44 African American volunteers endorsing cognitive concerns (37 females, 7 males) age≥65years with CogState battery subtests and recorded resting-state EEG, with eyes closed...
September 6, 2016: International Journal of Psychophysiology
Jolanta Krukowska, Marcin Bugajski, Monika Sienkiewicz, Jan Czernicki
In stroke patients, the NDT - (Bobath - Neurodevelopmental Treatment) and PNF (Proprioceptive Neuromuscular Facilitation) methods are used to achieve the main objective of rehabilitation, which aims at the restoration of maximum patient independence in the shortest possible period of time (especially the balance of the body). The aim of the study is to evaluate the effect of the NDT-Bobath and PNF methods on the field support and total path length measure foot pressure (COP) in patients after stroke. The study included 72 patients aged from 20 to 69 years after ischemic stroke with Hemiparesis...
August 20, 2016: Neurologia i Neurochirurgia Polska
W Kerr, S G Pierce, P Rowe
Synthetic aperture imaging methods have been employed widely in recent research in non-destructive testing (NDT), but uptake has been more limited in medical ultrasound imaging. Typically offering superior focussing power over more traditional phased array methods, these techniques have been employed in NDT applications to locate and characterise small defects within large samples, but have rarely been used to image surfaces. A desire to ultimately employ ultrasonic surface imaging for bone surface geometry measurement prior to surgical intervention motivates this research, and results are presented for initial laboratory trials of a surface reconstruction technique based on global thresholding of ultrasonic 3D point cloud data...
December 2016: Ultrasonics
Xudong Yu, Madis Ratassepp, Prabhu Rajagopal, Zheng Fan
Ultrasonic guided waves have proven to be attractive to the long-range testing of composite laminates. As complex-shaped composite components are increasingly incorporated in high-performance structures, understanding of both anisotropic and geometric effects on guided waves propagation is needed to evaluate their suitability for the non-destructive testing (NDT) of such complex structures. This paper reports the Semi-Analytical Finite Element (SAFE) simulations revealing the capability of energy confinement carried by two types of guided modes in 90° carbon fiber/epoxy (CF/EP) bends...
December 2016: Ultrasonics
César Yutaka Ofuchi, Fabio Rizental Coutinho, Flávio Neves, Lucia Valéria Ramos de Arruda, Rigoberto Eleazar Melgarejo Morales
In this paper the extended autocorrelation velocity estimator is evaluated and compared using a nondestructive ultrasonic device. For this purpose, three velocity estimators are evaluated and compared. The autocorrelation method (ACM) is the most used and well established in current ultrasonic velocity profiler technology, however, the technique suffers with phase aliasing (also known as the Nyquist limit) at higher velocities. The cross-correlation method (CCM) is also well known and does not suffer with phase aliasing as it relies on time shift measurements between emissions...
2016: Sensors
İlkay Karabay, Asuman Doğan, Timur Ekiz, Belma Füsun Köseoğlu, Murat Ersöz
OBJECTIVE: To elucidate the effects of Kinesio Taping (KT) in addition to neurodevelopmental therapy (NDT) on posture and sitting, and to compare the effects of KT and neuromuscular electrical stimulation (NMES). MATERIALS-METHODS: Seventy-five children were randomized into control, KT, and NMES groups. NDT was applied to all children 4 times a week for 4 weeks. In addition, KT and NMES were applied to KT and NMES groups, respectively. Sitting subset of Gross Motor Function Measure (GMFM) and kyphosis levels of the groups were analyzed by two way mixed ANOVA...
August 2016: Complementary Therapies in Clinical Practice
Marie Tré-Hardy, Arnaud Capron, Marina Venzon Antunes, Rafael Linden, Pierre Wallemacq
The purpose of this study was to develop and validate a new liquid chromatography-tandem mass spectrometric (LC-MSMS) assay for the simultaneous quantification of tamoxifen (TAM) and its main therapeutically active metabolites, N-desmethyltamoxifen (NDT), 4-hydroxytamoxifen (4HT) and endoxifen (END) in dried blood spots. Ultrasound assisted methanolic extraction was used for TAM and metabolites extraction from dried blood spot. After evaporation and methanol reconstitution, the extract was injected into a LC-MSMS system...
August 3, 2016: Clinical Biochemistry
Stanislas Lagarde, Francesca Bonini, Aileen McGonigal, Patrick Chauvel, Martine Gavaret, Didier Scavarda, Romain Carron, Jean Régis, Sandrine Aubert, Nathalie Villeneuve, Bernard Giusiano, Dominique Figarella-Branger, Agnès Trebuchon, Fabrice Bartolomei
OBJECTIVES: The study of intracerebral electroencephalography (EEG) seizure-onset patterns is crucial to accurately define the epileptogenic zone and guide successful surgical resection. It also raises important pathophysiologic issues concerning mechanisms of seizure generation. Until now, several seizure-onset patterns have been described using distinct recording methods (subdural, depth electrode), mostly in temporal lobe epilepsies or with heterogeneous neocortical lesions. METHODS: We analyzed data from a cohort of 53 consecutive patients explored by stereoelectroencephalography (SEEG) and with pathologically confirmed malformation of cortical development (MCD; including focal cortical dysplasia [FCD] and neurodevelopmental tumors [NDTs])...
September 2016: Epilepsia
Floren Rubio, Edward D Blandford, Leonard J Bond
Ultrasonics has been used in many industrial applications for both sensing at low power and processing at higher power. Generally, the high power applications fall within the categories of liquid stream degassing, impurity separation, and sonochemical enhancement of chemical processes. Examples of such industrial applications include metal production, food processing, chemical production, and pharmaceutical production. There are many nuclear process streams that have similar physical and chemical processes to those applications listed above...
September 2016: Ultrasonics
Jin Hee Woo, Ki Ok Shin, Yul Hyo Lee, Ki Soeng Jang, Ju Yong Bae, Hee Tae Roh
[Purpose] The aim of this study was to investigate the effects of regular treadmill exercise on skeletal muscle Rictor-Akt and mTOR-Raptor-S6K1 signaling pathway in high-fat diet-induced obese mice. [Subjects and Methods] Four- week-old C57BL/6 mice were adopted and classified into normal diet group (ND, n = 10), normal diet and training group (NDT, n = 10), high-fat diet group (HF, n = 10), and high-fat diet and training group (HFT, n = 10). The exercise program consisted of a treadmill exercise provided at low intensity for 1-4 weeks, and moderate intensity for 5-8 weeks...
April 2016: Journal of Physical Therapy Science
Candy T W Lam, Amy G W Gong, Kelly Y C Lam, Laura M Zhang, Jian-Ping Chen, Tina T X Dong, Huang-Quan Lin, Karl W K Tsim
ETHNOPHARMACOLOGICAL RELEVANCE: The fruit of Ziziphus jujuba (Mill.), known as Jujuba Fructus (JF) or jujube, is a well-known Traditional Chinese Medicine (TCM) for blood nourishment and sedation effect. Apart from prescribing as single herb alone, JF is very often being included in multi-herbal decoctions to prolong, enhance and harmonize pharmaceutical effects of decoctions while at the same time reducing toxicity. Here, we aimed to compare the protective and differentiating activities of three chemically standardized jujube-containing decoctions, including Guizhi Tang (GZT), Neibu Dangguijianzhong Tang (NDT) and ZaoTang (ZOT) in cultured PC12 cells...
July 21, 2016: Journal of Ethnopharmacology
Bin Gao, Wai Lok Woo, Gui Yun Tian
Electromagnetic mechanism of Joule heating and thermal conduction on conductive material characterization broadens their scope for implementation in real thermography based Nondestructive testing and evaluation (NDT&E) systems by imparting sensitivity, conformability and allowing fast and imaging detection, which is necessary for efficiency. The issue of automatic material evaluation has not been fully addressed by researchers and it marks a crucial first step to analyzing the structural health of the material, which in turn sheds light on understanding the production of the defects mechanisms...
2016: Scientific Reports
Odoardo Picciolini, Michel Le Métayer, Dario Consonni, Massimo Cozzaglio, Matteo Porro, Verusca Gasparroni, Artemisia Panou, Fabio Mosca, Nicola Portinaro
BACKGROUND: Hip dislocation is common in children with cerebral palsy (CP). At birth they don't have musculoskeletal deformities but they develop over time due to the combined effects of the movement disorder and impaired gross motor function. Early detection and treatment of a hip at risk is needed to modify the natural of hip development in CP. AIM: To determine the effect of postural management treatment on hip displacement's progression in children CP. DESIGN: Prospective comparative non-randomized study...
May 6, 2016: European Journal of Physical and Rehabilitation Medicine
Monika Fleckenstein, Felix Grassmann, Moritz Lindner, Maximilian Pfau, Joanna Czauderna, Tobias Strunz, Claudia von Strachwitz, Steffen Schmitz-Valckenberg, Frank G Holz, Bernhard H F Weber
PURPOSE: To genetically characterize a subphenotype of geographic atrophy (GA) in AMD associated with rapid progression and a diffuse-trickling appearance on fundus autofluorescence imaging. METHODS: Patients from the Fundus Autofluorescence in Age-Related Macular Degeneration Study were phenotyped for diffuse-trickling GA (dt-GA; n = 44). DNA was analyzed for 10 known AMD-associated genetic variants. A genetic risk score (GRS) was calculated and compared with patients with nondiffuse-trickling GA (ndt-GA; n = 311) and individuals from the 1000 genomes project (1000G; n = 267)...
May 1, 2016: Investigative Ophthalmology & Visual Science
Karl T Fendt, Hubert Mooshofer, Stefan J Rupitsch, Helmut Ermert
Ultrasonic nondestructive testing of steel forgings aims at the detection and classification of material inhomogeneities to ensure the components fitness for use. Due to the high price and safety critical nature of large forgings for turbomachinery, there is great interest in the application of imaging algorithms to inspection data. However, small flaw indications that cannot be sufficiently resolved have to be characterized using amplitude-based quantification. One such method is the distance gain size method, which converts the maximum echo amplitudes into the diameters of penny-shaped equivalent size reflectors...
June 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
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