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https://www.readbyqxmd.com/read/29128914/simultaneous-determination-of-tolterodine-and-its-two-metabolites-5-hydroxymethyltolterodine-and-n-dealkyltolterodine-in-human-plasma-using-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study
#1
Young-Hoon Kim, Ji-Yeong Byeon, Se-Hyung Kim, Choong-Min Lee, Eui Hyun Jung, Won Ki Chae, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee
Tolterodine is a nonselective muscarinic antagonist that is indicated for the overactive urinary bladder and other urinary difficulties. We developed and validated a simple, rapid and sensitive high-performance liquid chromatography analytical method utilizing tandem mass spectrometry (LC-MS/MS) for the quantitation of tolterodine and its major metabolites, 5-hydroxymethyltolterodine (5-HMT) and N-dealkyltolterodine (NDT), in human plasma. After liquid-liquid extraction with methyl t-butyl ether, chromatographic separation of the three analytes was achieved using a reversed-phase Luna Phenyl-hexyl column (100 × 2...
November 11, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29103551/decision-support-tools-in-low-back-pain
#2
REVIEW
Veerle M H Coupé, Miranda L van Hooff, Marinus de Kleuver, Ewout W Steyerberg, Raymond W J G Ostelo
Information from individual classification systems or clinical prediction rules that aim to facilitate stratified care in low back pain is important but often not comprehensive enough to be used to support clinical decision-making. The development and implementation of a clinically useful decision support tool (DST) that considering all key features is a challenging enterprise, requiring a multidisciplinary approach. Key features are inclusion of all relevant treatment options, patient characteristics, and benefits and harms and presentation as an accessible and easy to use toolkit...
December 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29078096/guided-ultrasonic-waves-for-determining-effective-orthotropic-material-parameters-of-continuous-fiber-reinforced-thermoplastic-plates
#3
Manuel Webersen, Sarah Johannesmann, Julia Düchting, Leander Claes, Bernd Henning
Ultrasonic methods are widely established in the NDE/NDT community, where they are mostly used for the detection of flaws and structural damage in various components. A different goal, despite the similar technological approach, is non-destructive material characterization, i.e. the determination of parameters like Young's modulus. Only few works on this topic have considered materials with high damping and strong anisotropy, such as continuous-fiber reinforced plastics, but due to the increasing demand in the industry, appropriate methods are needed...
October 6, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29071541/nutrient-drink-test-normative-values-in-indian-children
#4
Upender Shava, Anshu Srivastava, Amrita Mathias, Surender Kumar Yachha, Ujjal Poddar
BACKGROUND: Nutrient drink test (NDT) is a simple, non-invasive method to assess gastric function including accommodation. However, data on normal satiety drink volume (SDV) in children is scanty with no information about postprandial symptoms (PPS). Our aims were to establish normal values of NDT in healthy children and evaluate its correlation with age, gender, and anthropometry. METHODS: Six- to 18-year-old healthy children underwent the NDT. The nutrient drink (0...
October 25, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28957689/-the-effects-of-family-centered-physiotherapy-on-the-cognitive-and-motor-performance-in-premature-infants
#5
Bulent Elbasan, Murat Fatih Kocyigit, A Sebnem Soysal-Acar, Yıldız Atalay, Kivilcim Gucuyener
OBJECTIVE: The aim of this study is to investigate the effects of family centered physiotherapy according to the neurodevelopmental treatment (NDT) principles on mental and motor performance in premature infants. METHODS: A total of 156 infant, ≥24/36 week+6days gestational age included in the study. All the infants were diagnosed by a child neurologist and referred to psychology and physiotherapy department for their neurodevelopmental assessment and treatment...
September 25, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28956855/eddy-current-testing-with-giant-magnetoresistance-gmr-sensors-and-a-pipe-encircling-excitation-for-evaluation-of-corrosion-under-insulation
#6
Joseph Bailey, Nicholas Long, Arvid Hunze
This work investigates an eddy current-based non-destructive testing (NDT) method to characterize corrosion of pipes under thermal insulation, one of the leading failure mechanisms for insulated pipe infrastructure. Artificial defects were machined into the pipe surface to simulate the effect of corrosion wall loss. We show that by using a giant magnetoresistance (GMR) sensor array and a high current (300 A), single sinusoidal low frequency (5-200 Hz) pipe-encircling excitation scheme it is possible to quantify wall loss defects without removing the insulation or weather shield...
September 28, 2017: Sensors
https://www.readbyqxmd.com/read/28946545/impact-of-foot-pronation-on-postural-stability-an-observational-study
#7
Ghada Mohamed Koura, Doaa Ayoub Elimy, Hamada Ahmed Hamada, Hossam Eddien Fawaz, Mohamed Hussein Elgendy, Ibtissam M Saab
OBJECTIVE: To investigate the effect of foot pronation on the dynamic balance including overall stability index (OAI), anteroposterior stability index (APSI) and mediolateral stability index (MLSI). METHODS: Forty participants from both sexes were selected from the Faculty of Physical Therapy, Cairo University, with a mean age of 23.55 ± 1.74 years. Subjects were divided into two groups: group A (8 males and 12 females) with foot pronation, and group B (9 males and 11 females) with normal feet...
September 15, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28927269/discovery-of-tamoxifen-and-n-desmethyl-tamoxifen-protein-targets-in-mcf-7-cells-using-large-scale-protein-folding-and-stability-measurements
#8
Ryenne N Ogburn, Lorrain Jin, He Meng, Michael C Fitzgerald
The proteins in an MCF-7 cell line were probed for tamoxifen (TAM) and n-desmethyl tamoxifen (NDT) induced stability changes using the Stability of Proteins from Rates of Oxidation (SPROX) technique in combination with two different quantitative proteomics strategies, including one based on SILAC and one based on isobaric mass tags. Over 1000 proteins were assayed for TAM- and NDT-induced protein stability changes, and a total of 163 and 200 protein hits were identified in the TAM and NDT studies, respectively...
November 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28894172/extraordinary-transport-characteristics-and-multivalue-logic-functions-in-a-silicon-based-negative-differential-transconductance-device
#9
Sejoon Lee, Youngmin Lee, Changmin Kim
High-performance negative-differential transconductance (NDT) devices are fabricated in the form of a gated p(+)-i-n(+) Si ultra-thin body transistor. The devices clearly display a Λ-shape transfer characteristic (i.e., Λ-NDT peak) at room temperature, and the NDT behavior is fully based on the gate-modulation of the electrostatic junction characteristics along source-channel-drain. The largest peak-to-valley current ratio of the Λ-NDT peak is greater than 10(4), the smallest full-width at half-maximum is smaller than 170 mV, and the best swing-slope at the Λ-NDT peak region is ~70 mV/dec...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869434/effects-of-neuromuscular-electrical-stimulation-and-kinesio-taping-applications-in-children-with-cerebral-palsy-on-postural-control-and-sitting-balance
#10
Bülent Elbasan, Kamile Uzun Akkaya, Mufit Akyüz, Deran Oskay
BACKGROUND: Neurodevelopmental treatment (NDT), neuromuscular electrical stimulation (NMES), and Kinesio Taping (KT) applications are separately used to improve postural control and sitting balance in children with cerebral palsy (CP). OBJECTIVE: The aim of this study is to examine the combined effect of NDT, NMES and KT applications on postural control and sitting balance in children with CP. METHODS: Forty five children, in 3 groups, between the ages 5-12 years were included in the study...
August 21, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28867790/development-of-embedded-em-sensors-for-estimating-tensile-forces-of-psc-girder-bridges
#11
Junkyeong Kim, Ju-Won Kim, Chaggil Lee, Seunghee Park
The tensile force of pre-stressed concrete (PSC) girders is the most important factor for managing the stability of PSC bridges. The tensile force is induced using pre-stressing (PS) tendons of a PSC girder. Because the PS tendons are located inside of the PSC girder, the tensile force cannot be measured after construction using conventional NDT (non-destructive testing) methods. To monitor the induced tensile force of a PSC girder, an embedded EM (elasto-magnetic) sensor was proposed in this study. The PS tendons are made of carbon steel, a ferromagnetic material...
August 30, 2017: Sensors
https://www.readbyqxmd.com/read/28858230/a-smart-eddy-current-sensor-dedicated-to-the-nondestructive-evaluation-of-carbon-fibers-reinforced-polymers
#12
Mohammed Naidjate, Bachir Helifa, Mouloud Feliachi, Iben-Khaldoun Lefkaier, Henning Heuer, Martin Schulze
This paper propose a new concept of an eddy current (EC) multi-element sensor for the characterization of carbon fiber-reinforced polymers (CFRP) to evaluate the orientations of plies in CFRP and the order of their stacking. The main advantage of the new sensors is the flexible parametrization by electronical switching that reduces the effort for mechanical manipulation. The sensor response was calculated and proved by 3D finite element (FE) modeling. This sensor is dedicated to nondestructive testing (NDT) and can be an alternative for conventional mechanical rotating and rectangular sensors...
August 31, 2017: Sensors
https://www.readbyqxmd.com/read/28815050/a-case-of-azoospermia-in-a-non-destructive-testing%C3%A2-worker-exposed-to-radiation
#13
Jaechan Park, Sanggil Lee, Chulyong Park, Huisu Eom
BACKGROUND: Interest in radiation-related health problems has been growing with the increase in the number of workers in radiation-related jobs. Although an occupational level of radiation exposure would not likely cause azoospermia, several studies have reported the relation between radiation exposure and azoospermia after accidental or therapeutic radiation exposure. We describe a case of azoospermia in a non-destructive testing (NDT) worker exposed to radiation and discuss the problems of the related monitoring system...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28810727/ndt-digest-rapid-revelations-in-renal-disease
#14
Kate Stevens, Denis Fouque
No abstract text is available yet for this article.
August 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28773149/using-biotechnology-to-solve-engineering-problems-non-destructive-testing-of-microfabrication-components
#15
Carla C C R de Carvalho, Patrick L Inácio, Rosa M Miranda, Telmo G Santos
In an increasingly miniaturised technological world, non-destructive testing (NDT) methodologies able to detect defects at the micro scale are necessary to prevent failures. Although several existing methods allow the detection of defects at that scale, their application may be hindered by the small size of the samples to examine. In this study, the application of bacterial cells to help the detection of fissures, cracks, and voids on the surface of metals is proposed. The application of magnetic and electric fields after deposition of the cells ensured the distribution of the cells over the entire surfaces and helped the penetration of the cells inside the defects...
July 12, 2017: Materials
https://www.readbyqxmd.com/read/28772980/sparse-and-dispersion-based-matching-pursuit-for-minimizing-the-dispersion-effect-occurring-when-using-guided-wave-for-pipe-inspection
#16
Javad Rostami, Peter W T Tse, Zhou Fang
Ultrasonic guided wave is an effective tool for structural health monitoring of structures for detecting defects. In practice, guided wave signals are dispersive and contain multiple modes and noise. In the presence of overlapped wave-packets/modes and noise together with dispersion, extracting meaningful information from these signals is a challenging task. Handling such challenge requires an advanced signal processing tool. The aim of this study is to develop an effective and robust signal processing tool to deal with the complexity of guided wave signals for non-destructive testing (NDT) purpose...
June 6, 2017: Materials
https://www.readbyqxmd.com/read/28764143/prevalence-of-flexible-flat-foot-in-adults-a-cross-sectional-study
#17
Ashok Aenumulapalli, Manoj Mohan Kulkarni, Achleshwar Ramnarain Gandotra
INTRODUCTION: Flat foot (pes planus) is a commonly observed disorder in clinical practice. The height of Medial Longitudinal Arch (MLA) determines the degree of pes planus. Majority of the previous studies on prevalence of flexible flat foot were done among children. AIM: The present study was undertaken to determine the prevalence of flexible flat foot among 18-21-year-old Indian adults using Navicular Drop Test (NDT) which is regarded as reliable and valid method to characterise MLA...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28744053/the-effect-of-motor-imagery-training-for-trunk-movements-on-trunk-muscle-control-and-proprioception-in-stroke-patients
#18
Dong-Sik Oh, Jong-Duk Choi
[Purpose] The present study was conducted to evaluate the effect of motor imagery training for trunk movements on trunk muscle control and proprioception in stroke patients. [Subjects and Methods] A total of 12 study subjects were randomly assigned to the experimental group (a motor imagery training group) and the control group (a neurodevelopmental treatment, NDT) group. The two groups were treated five times (30 minutes each time) per week for 4 weeks. The experimental group underwent imagery training for 10 minutes and trunk control centered NDT for 20 minutes and the control group underwent only trunk control centered NDT for 30 minutes...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28710572/tuning-the-electronic-and-optical-properties-of-ndt-based-conjugated-polymers-by-adopting-fused-heterocycles-as-acceptor-units-a-theoretical-study
#19
Na Cheng, Changqiao Zhang, Yongjun Liu
Donor-acceptor conjugated polymers have been successfully applied in bulk heterojunction solar cell devices. Tuning their donor and acceptor units allows the design of new polymers with desired electronic and optical properties. Here, to screen new candidate polymers based on a newly synthesized donor unit, dithieo[2,3-d:2',3'-d']naphtho[1,2-b:3,4-b']dithiophene (NDT), a series of model polymers with different acceptor units were designed and denoted NDT-A0 to NDT-A12, and the structures and optical properties of those polymers were investigated using DFT and TDDFT calculations...
August 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28609089/light-triggered-ternary-device-and-inverter-based-on-heterojunction-of-van-der-waals-materials
#20
Jaewoo Shim, Seo-Hyeon Jo, Minwoo Kim, Young Jae Song, Jeehwan Kim, Jin-Hong Park
Multivalued logic (MVL) devices/circuits have received considerable attention because the binary logic used in current Si complementary metal-oxide-semiconductor (CMOS) technology cannot handle the predicted information throughputs and energy demands of the future. To realize MVL, the conventional transistor platform needs to be redesigned to have two or more distinctive threshold voltages (VTHs). Here, we report a finding: the photoinduced drain current in graphene/WSe2 heterojunction transistors unusually decreases with increasing gate voltage under illumination, which we refer to as the light-induced negative differential transconductance (L-NDT) phenomenon...
June 27, 2017: ACS Nano
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