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Freezing of gait

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https://www.readbyqxmd.com/read/29902715/anticipatory-postural-responses-prior-to-protective-steps-are-not-different-in-people-with-pd-who-do-and-do-not-freeze
#1
D S Peterson, K R Lohse, M Mancini
BACKGROUND: Protective stepping after a loss of balance is related to falls. Anticipatory postural responses (APAs) prior to protective stepping can impact step performance, may be larger in people with PD, and have been suggested to be related to freezing of gait (FOG). However, whether people with PD and FOG (PD + FOG) exhibit larger APAs than people with PD and no FOG (PD-FOG) is unknown. RESEARCH QUESTION: Determine the impact of freezing status on APAs prior to protective steps, thus providing a better understanding of the link between FOG and APAs...
June 5, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29902470/automated-mechanical-peripheral-stimulation-effects-on-gait-variability-in-individuals-with-parkison-s-disease-and-freezing-of-gait-a-double-blind-randomized-controlled-trial-ms-ref-no-archives-pmr-d-18-00162
#2
Ana Francisca Rozin Kleiner, Aline de Souza Pagnussat, Camila Pinto, Ritchele Rovido, Ana Paula Salazar, Manuela Galli
OBJECTIVE: to assess the effects of Automated Peripheral Stimulation (AMPS) in reducing gait variability of subjects with Parkinson's Disease (PD) and freezing of gait (FOG) treated with AMPS and to explore the effects of this treatment on gait during a single task (walking) and a dual task (walking while attending the word-color Stroop test). DESIGN: interventional, double-blinded, placebo-controlled, randomized trial. SETTING: Clinical rehabilitation...
June 11, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29891430/association-of-metals-with-the-risk-and-clinical-characteristics-of-parkinson-s-disease
#3
Mi-Jung Kim, Shin-Bi Oh, Juyeon Kim, Kiju Kim, Ho-Sung Ryu, Min Sun Kim, Scott Ayton, Ashley I Bush, Joo-Yong Lee, Sun Ju Chung
INTRODUCTION: While metals have been implicated in the pathophysiology of Parkinson's disease (PD), the clinical evidence is scarce. Further, the contribution of metals for the risk or clinical presentation of PD remains to be explored. METHODS: To investigate the associations between the level of metals in blood serum and PD risk or clinical presentation, including sex-related differences, we studied 325 PD patients and age- and sex-matched 304 controls. We collected clinical data of the PD patients, including age at onset, PD duration, levodopa-equivalent dose (LED), Hoehn and Yahr stage (H-Y stage), presence of motor fluctuation, levodopa-induced dyskinesia (LID), freezing of gait, hallucination, and Mini-Mental State Examination (MMSE) score...
May 28, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29867708/method-of-levodopa-response-calculation-determines-strength-of-association-with-clinical-factors-in-parkinson-disease
#4
Marcus Pieterman, Scott Adams, Mandar Jog
Background: The levodopa challenge test is routinely used in Parkinson disease (PD) to determine a patient's motor improvement following levodopa administration [levodopa response (LR)]. LR is most commonly reported as a percent OFF to ON change in the Unified Parkinson Disease Rating Scale (UPDRS) part III score, and occasionally as an absolute difference in score. This inconsistency in LR determination alters how clinical factors such as patient age and disease duration are understood in relation to LR in PD...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29860785/prospective-characterization-of-cognitive-function-in-typical-and-brainstem-predominant-progressive-supranuclear-palsy-phenotypes
#5
Young-Eun C Lee, David R Williams, Jacqueline F I Anderson
OBJECTIVE: Clinicopathological studies over the last decade have broadened the clinical spectrum of progressive supranuclear palsy (PSP) to include several distinct clinical syndromes. We examined the cognitive profiles of patients with PSP-Richardson's syndrome (PSP-RS) and two atypical 'brainstem predominant' PSP phenotypes (PSP-parkinsonism, PSP-P; and PSP-pure akinesia with gait freezing, PSP-PAGF) using a comprehensive neuropsychological battery. METHODS: Fourteen patients diagnosed as PSP-RS, three patients with PSP-P and four patients with PSP-PAGF were assessed using a comprehensive battery of neuropsychological tests...
May 2018: Journal of Movement Disorders
https://www.readbyqxmd.com/read/29846707/deep-brain-stimulation-of-the-pedunculopontine-nucleus-area-in-parkinson-disease-mri-based-anatomoclinical-correlations-and-optimal-target
#6
Laurent Goetz, Manik Bhattacharjee, Murielle U Ferraye, Valérie Fraix, Carina Maineri, Daniela Nosko, Albert J Fenoy, Brigitte Piallat, Napoléon Torres, Alexandre Krainik, Eric Seigneuret, Olivier David, Martin Parent, André Parent, Pierre Pollak, Alim-Louis Benabid, Bettina Debu, Stéphan Chabardès
BACKGROUND: Experimental studies led to testing of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) as a new therapy to treat freezing of gait (FOG) in Parkinson disease (PD). Despite promising initial results fueling a growing interest toward that approach, several clinical studies reported heterogeneity in patient responses. Variation in the position of electrode contacts within the rostral brainstem likely contributes to such heterogeneity. OBJECTIVE: To provide anatomoclinical correlations of the effect of DBS of the caudal mesencephalic reticular formation (cMRF) including the PPN to treat FOG by comparing the normalized positions of the active contacts among a series of 11 patients at 1- and 2-yr follow-up and to provide an optimal target through an open-label study...
May 25, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29843253/cardinal-motor-features-of-parkinson-s-disease-coexist-with-peak-dose-choreic-type-drug-induced-dyskinesia-parkinson-s-symptoms-coexist-with-dyskinesia
#7
Etienne Goubault, Hung P Nguyen, Sarah Bogard, Pierre J Blanchet, Erwan Bézard, Claude Vincent, Mélanie Langlois, Christian Duval
BACKGROUND: Clinical and anecdotal observations propose that patients with Parkinson's disease (PD) may show drug-induced dyskinesia (DID) concomitantly with cardinal motor features. However, the extent of the concomitant presence of DID and cardinal features remains to be determined. OBJECTIVES: This cross-sectional study measured peak-dose, choreic-type DID in a quantitative manner in patients diagnosed with PD, and determined whether symptoms such as tremor, bradykinesia, rigidity, postural instability or freezing of gait (FoG) were still detectable in these patients...
May 19, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29801899/can-early-dopamine-transporter-imaging-serve-as-a-predictor-of-parkinson-s-disease-progression-and-late-motor-complications
#8
Ruth Djaldetti, Amihai Rigbi, Lior Greenbaum, Johnathan Reiner, Mordechai Lorberboym
BACKGROUND: The role of nuclear imaging in predicting Parkinson's disease (PD) progression is unclear. This study investigated whether the degree of reduced striatal dopamine transporter binding at diagnosis of PD predicts later motor complications and time to disease progression. METHODS: We retrospectively studied 41 patients with early PD who underwent 123 I-FP-CIT SPECT and were followed thereafter with a mean disease duration of 9.51 ± 3.18 years. The association of quantitatively analyzed 123 I-FP-CIT binding in striatal subregions with the development of motor fluctuations, dyskinesias, freezing of gait (FOG) and falls as well as the time to Hoehn and Yahr (H&Y) stage 3 was evaluated...
July 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29796409/cognitive-training-for-freezing-of-gait-in-parkinson-s-disease-a-randomized-controlled-trial
#9
Courtney C Walton, Loren Mowszowski, Moran Gilat, Julie M Hall, Claire O'Callaghan, Alana J Muller, Matthew Georgiades, Jennifer Y Y Szeto, Kaylena A Ehgoetz Martens, James M Shine, Sharon L Naismith, Simon J G Lewis
The pathophysiological mechanism of freezing of gait (FoG) has been linked to executive dysfunction. Cognitive training (CT) is a non-pharmacological intervention which has been shown to improve executive functioning in Parkinson's disease (PD). This study aimed to explore whether targeted CT can reduce the severity of FoG in PD. Patients with PD who self-reported FoG and were free from dementia were randomly allocated to receive either a CT intervention or an active control. Both groups were clinician-facilitated and conducted twice-weekly for seven weeks...
2018: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29790385/kinect4fog-monitoring-and-improving-mobility-in-people-with-parkinson-s-using-a-novel-system-incorporating-the-microsoft-kinect-v2
#10
Amin Amini, Konstantinos Banitsas, William R Young
Parkinson's is a neurodegenerative condition associated with several motor symptoms including tremors and slowness of movement. Freezing of gait (FOG); the sensation of one's feet being "glued" to the floor, is one of the most debilitating symptoms associated with advanced Parkinson's. FOG not only contributes to falls and related injuries, but also compromises quality of life as people often avoid engaging in functional daily activities both inside and outside the home. In the current study, we describe a novel system designed to detect FOG and falling in people with Parkinson's (PwP) as well as monitoring and improving their mobility using laser-based visual cues cast by an automated laser system...
May 23, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29773512/increased-foot-strike-variability-in-parkinson-s-disease-patients-with-freezing-of-gait
#11
Jesal Shah, Lakshmi Pillai, David K Williams, Shannon M Doerhoff, Linda Larson-Prior, Edgar Garcia-Rill, Tuhin Virmani
INTRODUCTION: Freezing of gait (FOG) is a debilitating, late motor complication of Parkinson's disease (PD) that occurs in 50-80% of patients. Gait freezing significantly worsens quality of life by decreasing mobility and increasing falls. Studies have shown that patients with episodic freezing episodes also have deficits in continuous gait. We evaluated whether there was an objective gait correlate to the increased stumbling reported by many patients with gait freezing. METHODS: PD subjects and healthy controls (HC) were enrolled after IRB approval...
May 1, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29754837/effects-of-exercise-on-gait-and-motor-imagery-in-people-with-parkinson-disease-and-freezing-of-gait
#12
Peter S Myers, Marie E McNeely, Kristen A Pickett, Ryan P Duncan, Gammon M Earhart
INTRODUCTION: Exercise improves gait in Parkinson disease (PD), but whether exercise differentially affects people with PD with (freezers) and without freezing of gait (non-freezers) remains unclear. This study examines exercise's effects on gait performance, neural correlates related to these effects, and potential neural activation differences between freezers and non-freezers during motor imagery (MI) of gait. METHODS: Thirty-seven participants from a larger exercise intervention completed behavioral assessments and functional magnetic resonance imaging (fMRI) scans before and after a 12-week exercise intervention...
May 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29734949/a-case-of-hyperparathyroidism-associated-parkinsonism-successfully-treated-with-cinacalcet-hydrochloride-a-calcimimetic
#13
Yuichiro Ohya, Masato Osaki, Shota Sakai, Shunsuke Kimura, Chiharu Yasuda, Tetsuro Ago, Takanari Kitazono, Shuji Arakawa
BACKGROUND: Some metabolic disorders, including abnormal calcium metabolism, can develop and worsen parkinsonism. However, whether hyperparathyroidism can cause parkinsonism remains controversial. CASE PRESENTATION: An 83-year-old woman with a history of right thalamic hemorrhage and drug-induced parkinsonism, was admitted due to worsening of parkinsonian symptoms including mask-like face, bradykinesia, freezing of gait, and rigidity. She had been diagnosed with autoimmune hepatitis and was being treated with prednisolone...
May 7, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29710736/provoking-freezing-of-gait-in-clinical-practice-turning-in-place-is-more-effective-than-stepping-in-place
#14
Karlijn van Dijsseldonk, Ying Wang, Richard van Wezel, Bastiaan R Bloem, Jorik Nonnekes
No abstract text is available yet for this article.
April 25, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29708870/validation-of-freezing-of-gait-monitoring-using-smartphone
#15
Han Byul Kim, Hong Ji Lee, Woong Woo Lee, Sang Kyong Kim, Hyo Seon Jeon, Hye Young Park, Chae Won Shin, Won Jin Yi, Beomseok Jeon, Kwang S Park
BACKGROUND: Freezing of gait (FOG) is a commonly observed motor symptom for patients with Parkinson's disease (PD). The symptoms of FOG include reduced step lengths or motor blocks, even with an evident intention of walking. FOG should be monitored carefully because it not only lowers the patient's quality of life, but also significantly increases the risk of injury. INTRODUCTION: In previous studies, patients had to wear several sensors on the body and another computing device was needed to run the FOG detection algorithm...
April 30, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29702698/comprehensive-behavioral-analysis-of-the-cdkl5-knockout-mice-revealed-significant-enhancement-in-anxiety-and-fear-related-behaviors-and-impairment-in-both-acquisition-and-long-term-retention-of-spatial-reference-memory
#16
Kosuke Okuda, Keizo Takao, Aya Watanabe, Tsuyoshi Miyakawa, Masashi Mizuguchi, Teruyuki Tanaka
Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe neurodevelopmental disorders. Recently we have generated Cdkl5 KO mice by targeting exon 2 on the C57BL/6N background, and demonstrated postsynaptic overaccumulation of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the hippocampus. In the current study, we subjected the Cdkl5 KO mice to a battery of comprehensive behavioral tests, aiming to reveal the effects of loss of CDKL5 in a whole perspective of motor, emotional, social, and cognition/memory functions, and to identify its undetermined roles...
2018: PloS One
https://www.readbyqxmd.com/read/29696615/influence-of-cognitive-impairment-on-the-freezing-of-gait-in-non-demented-people-with-parkinson-s-disease
#17
J M Cancela, C M Nascimento, S Varela, M Seijo-Martinez, L Lorenzo-Lopez, J C Millan-Calenti, C Dominguez-Vivero, C Ayan
INTRODUCTION: Freezing of gait (FOG) is a motor disturbance usually appearing in advanced Parkinson's disease (PD). Cognitive and executive function seems to play an important role in this phenomenon. AIM: To investigate if cognitive and kinematic parameters correlate with FOG in PD patients without dementia. PATIENTS AND METHODS: We conducted an observational cross-sectional study. Participants were classified in two groups: freezers and non-freezers...
May 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29673947/handwritten-dynamics-assessment-through-convolutional-neural-networks-an-application-to-parkinson-s-disease-identification
#18
Clayton R Pereira, Danilo R Pereira, Gustavo H Rosa, Victor H C Albuquerque, Silke A T Weber, Christian Hook, João P Papa
BACKGROUND AND OBJECTIVE: Parkinson's disease (PD) is considered a degenerative disorder that affects the motor system, which may cause tremors, micrography, and the freezing of gait. Although PD is related to the lack of dopamine, the triggering process of its development is not fully understood yet. METHODS: In this work, we introduce convolutional neural networks to learn features from images produced by handwritten dynamics, which capture different information during the individual's assessment...
May 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29662465/the-length-of-snca-rep1-microsatellite-may-influence-cognitive-evolution-in-parkinson-s-disease
#19
Lucia Corrado, Fabiola De Marchi, Sara Tunesi, Gaia Donata Oggioni, Miryam Carecchio, Luca Magistrelli, Silvana Tesei, Giulio Riboldazzi, Alessio Di Fonzo, Clarissa Locci, Ilaria Trezzi, Roberta Zangaglia, Cristina Cereda, Sandra D'Alfonso, Corrado Magnani, Giacomo P Comi, Giorgio Bono, Claudio Pacchetti, Roberto Cantello, Stefano Goldwurm, Cristoforo Comi
Background: Alpha-synuclein is a constituent of Lewy bodies and mutations of its gene cause familial Parkinson's disease (PD). A previous study showed that a variant of the alpha-synuclein gene ( SNCA ), namely the 263 bp allele of Rep1 was associated with faster motor progression in PD. On the contrary, a recent report failed to detect a detrimental effect of Rep1 263 on both motor and cognitive outcomes in PD. Aim of this study was to evaluate the influence of the Rep1 variants on disease progression in PD patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29648576/life-space-mobility-in-parkinson-s-disease-associations-with-motor-and-non-motor-symptoms
#20
Merja Rantakokko, Susanne Iwarsson, Björn Slaug, Maria H Nilsson
Background: To describe life-space mobility and explore associations of motor and non-motor symptoms with life-space mobility in people with Parkinson's disease (PD). Methods: 164 community-dwelling persons with PD (mean age 71.6 years, 64.6% men) received a postal survey and a subsequent home visit. Motor assessments included perceived walking difficulties (Walk-12G), mobility (Timed Up and Go test), motor symptoms (UPDRS-III) and freezing of gait (item 3, FOG-Qsa)...
April 10, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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