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Freezing of gait

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https://www.readbyqxmd.com/read/29471292/step-numbers-and-hoehn-yahr-stage-after-six-years
#1
Hiroshi Kataoka, Noriyuki Tanaka, Takao Kiriyama, Nobuyuki Eura, Masanori Ikeda, Tesseki Izumi, Yoshiko Furiya, Kazuma Sugie, Satoshi Ueno
BACKGROUND: Freezing of gait (FOG) has been linked to increased numbers of steps taken while walking. We tested the hypothesis that an increased number of steps associated with FOG might predict the exacerbation of the severity of Parkinson's disease (PD). METHODS: We prospectively studied 26 patients. Clinical assessments were performed and balance was evaluated in 30 patients with Hoehn-Yahr stage III PD 6 years previously. Gait parameters were analyzed with the use of an originally designed, suddenly narrowed path...
February 22, 2018: European Neurology
https://www.readbyqxmd.com/read/29444207/the-functional-network-signature-of-heterogeneity-in-freezing-of-gait
#2
Kaylena A Ehgoetz Martens, Julie M Hall, Matthew J Georgiades, Moran Gilat, Courtney C Walton, Elie Matar, Simon J G Lewis, James M Shine
Freezing of gait is a complex, heterogeneous, and highly variable phenomenon whose pathophysiology and neural signature remains enigmatic. Evidence suggests that freezing is associated with impairments across cognitive, motor and affective domains; however, most research to date has focused on investigating one axis of freezing of gait in isolation. This has led to inconsistent findings and a range of different pathophysiological models of freezing of gait, due in large part to the tendency for studies to investigate freezing of gait as a homogeneous entity...
February 9, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29442369/spinal-cord-stimulation-therapy-for-gait-dysfunction-in-advanced-parkinson-s-disease-patients
#3
Olivia Samotus, Andrew Parrent, Mandar Jog
BACKGROUND: Benefits of dopaminergic therapy and deep brain stimulation are limited and unpredictable for axial symptoms in Parkinson's disease. Dorsal spinal cord stimulation may be a new therapeutic approach. The objective of this study was to investigate the therapeutic effect of spinal cord stimulation on gait including freezing of gait in advanced PD patients. METHODS: Five male PD participants with significant gait disturbances and freezing of gait underwent midthoracic spinal cord stimulation...
February 14, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29436740/multitarget-transcranial-direct-current-stimulation-for-freezing-of-gait-in-parkinson-s-disease
#4
Moria Dagan, Talia Herman, Rachel Harrison, Junhong Zhou, Nir Giladi, Giulio Ruffini, Brad Manor, Jeffrey M Hausdorff
BACKGROUND: Recent findings suggest that transcranial direct current stimulation of the primary motor cortex may ameliorate freezing of gait. However, the effects of multitarget simultaneous stimulation of motor and cognitive networks are mostly unknown. The objective of this study was to evaluate the effects of multitarget transcranial direct current stimulation of the primary motor cortex and left dorsolateral prefrontal cortex on freezing of gait and related outcomes. METHODS: Twenty patients with Parkinson's disease and freezing of gait received 20 minutes of transcranial direct current stimulation on 3 separate visits...
February 13, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29434567/turn-around-freezing-community-living-turning-behavior-in-people-with-parkinson-s-disease
#5
Martina Mancini, Aner Weiss, Talia Herman, Jeffrey M Hausdorff
Difficulty in turning while walking is common among patients with Parkinson's disease (PD). This difficulty often leads to significant disability, falls, and loss of function; moreover, turning is a common trigger for freezing of gait (FoG). We hypothesized that the quantity and quality of turning mobility while walking during daily life would be different among subjects with PD with and without FoG. Here, we investigated, for the first time, the turning quality during daily life as it relates to FoG in people with PD using a single inertial sensor...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29413805/postural-control-deficit-during-sit-to-walk-in-patients-with-parkinson-s-disease-and-freezing-of-gait
#6
Susanna Mezzarobba, Michele Grassi, Roberto Valentini, Paolo Bernardis
INTRODUCTION: The intricate linkage between Freezing of Gait (FoG) and postural control in Parkinson's disease (PD) is unclear. We analyzed the impact of FoG on dynamic postural control. METHODS: 24 PD patients, 12 with (PD + FoG), 12 without FoG (PD-FoG), and 12 healthy controls, were assessed in ON state. Mobility and postural control were measured with clinical scales (UPDRS III, BBS, MPAS) and with kinematic and kinetic analysis during three tasks, characterized by levels of increasing difficulty to plan sequential movement of postural control: walk (W), gait initiation (GI) and sit-to-walk (STW)...
February 2, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29413804/impacts-of-freezing-of-gait-on-forward-and-backward-gait-in-parkinson-s-disease
#7
Minji Son, Sang-Myung Cheon, Changhong Youm, Youkyung Kim, Jae Woo Kim
Freezing of gait (FOG) is a major risk factor for falls and fall-related injuries in patients with Parkinson's disease (PD). The characteristics of gait in PD patients with FOG have been studied but remain controversial. To investigate gait characteristics of FOG in PD, this study analyzed the forward and backward walking of patients with PD. Twenty-six patients with PD were recruited [age: 71.0 ± 6.2 years, Hoehn and Yahr stage: 2-3 (median 2.5)]. Based on responses to the New Freezing of Gait Questionnaire, we classified patients into either the "freezer" or "non-freezer" group...
February 1, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29408498/dysfunctional-limbic-circuitry-underlying-freezing-of-gait-in-parkinson-s-disease
#8
Moran Gilat, Kaylena A Ehgoetz Martens, Oscar Miranda-Domínguez, Ishu Arpan, James M Shine, Martina Mancini, Damien A Fair, Simon J G Lewis, Fay B Horak
Freezing of gait (FOG) is a poorly understood symptom affecting many patients with Parkinson's disease (PD). Despite growing evidence of a behavioral link between anxiety, attention and FOG in PD, no research to date has investigated the neural mechanisms that might explain this relationship. The present study therefore examined resting-state MRI functional connectivity between the amygdala, striatum and frontoparietal attentional control network in PD patients with (freezers: n = 19) and without FOG (non-freezers: n = 21) in the dopaminergic 'off' state...
January 31, 2018: Neuroscience
https://www.readbyqxmd.com/read/29406886/effects-of-intestinal-levodopa-infusion-on-freezing-of-gait-in-parkinson-disease
#9
Maurizio Zibetti, Serena Angrisano, Francesca Dematteis, Carlo Alberto Artusi, Alberto Romagnolo, Aristide Merola, Leonardo Lopiano
OBJECTIVE: To determine the impact of levodopa-carbidopa intestinal gel (LCIG) infusion on different subtypes of freezing of gait (FoG) classified according to levodopa responsiveness in advanced Parkinson disease (PD) patients. METHODS: We retrospectively assessed the presence and severity of FoG in 32 advanced PD patients based on the Unified PD Rating Scale (UPDRS) item 14 score. Different FoG subtypes were inferred from the score variation with oral dopaminergic medications...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29398194/vestibular-symptoms-as-the-presenting-feature-of-progressive-supranuclear-palsy
#10
Lucy Haggstrom, Bruce Brew, Ian Sutton, Stephen Tisch
First described in 1964, progressive supranuclear palsy (PSP) is a chronic, sporadic, progressive neurodegenerative tauopathy. Substantial phenotypic variability inherent in PSP confers difficulty to diagnosis. Although the classic presentation, termed PSP-Richardson's syndrome, has been well described, additional variants of PSP are increasingly emerging. Phenotypes described to date include PSP-parkinsonism, PSP-pure akinesia with gait freezing, PSP-corticobasal syndrome or PSP-progressive non-fluent aphasia...
February 2, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29392774/gait-initiation-is-influenced-by-emotion-processing-in-parkinson-s-disease-patients-with-freezing
#11
Giovanna Lagravinese, Elisa Pelosin, Gaia Bonassi, Federico Carbone, Giovanni Abbruzzese, Laura Avanzino
BACKGROUND: Freezing of gait is a symptom that affects more than 50% of Parkinson's disease (PD) patients and increasing evidence suggests that nonmotor systems (i.e., limbic system) are involved in its underlying mechanisms. OBJECTIVE: The objective of this study was to investigate whether gait initiation characteristics are influenced by emotional stimuli in patients with PD, with or without freezing of gait. METHODS: A total of 44 participants, divided into 3 groups (15 PD patients with and 15 PD patients without freezing of gait and 14 controls), stood on a sensorized mat and were asked to take a step forward in response to a pleasant image and a step backward in response to an unpleasant one (congruent task, low cognitive load) or to take a step backward in response to a pleasant image and a step forward in response to an unpleasant one (incongruent task, high cognitive load)...
February 2, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29392077/clinical-profile-of-chinese-long-term-parkinson-s-disease-survivors-with-10-years-of-disease-duration-and-beyond
#12
Qian Sun, Tian Wang, Tian-Fang Jiang, Pei Huang, Ying Wang, Qin Xiao, Jun Liu, Sheng-Di Chen
Background: Parkinson's disease (PD) patients with 10 years or more survival (PD-10) are not well characterized. The aim of this study was to evaluate the main issues facing PD-10 patients and identify factors that independently contributed to quality of life (QoL). Methods: A group of 121 PD-10 patients recruited from outpatient clinics participated in this cross-sectional study. Data on demographic and clinical factors were collected. Multiple linear regression analyses were conducted to identify determinants of poor QoL...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29323400/-amimia-in-parkinson-s-disease-significance-and-correlation-with-the-clinical-features
#13
P J Garcia-Ruiz, C E Feliz-Feliz, T Maycas-Cepeda, J Del Val-Fernandez
INTRODUCTION: Reduced facial expression or amimia is one of the most typical characteristics of Parkinson's disease (PD). Despite being described in classic texts, its significance, physiopathology and correlation with motor and non-motor symptoms is largely unknown. PATIENTS AND METHODS: We have studied facial bradykinesia in a group of 84 de novo PD patients prospectively evaluated for five years. We also studied the relationship of facial bradykinesia with depression in a subgroup of 30 patients...
January 16, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29309313/automated-mechanical-peripheral-stimulation-improves-gait-parameters-in-subjects-with-parkinson-s-disease-and-freezing-of-gait-a-randomized-clinical-trial
#14
Camila Pinto, Aline de Souza Pagnussat, Ana Francisca Rozin Kleiner, Ritchele Redivo Marchese, Ana Paula Salazar, Carlos R M Rieder, Manuela Galli
OBJECTIVE: This study aimed to assess spatiotemporal gait parameters and lower limbs range of motion (ROM) in subjects with Parkinson's Disease (PD) and freezing of gait (FOG), treated with Automated Mechanical Peripheral Stimulation (AMPS) or AMPS SHAM (placebo). DESIGN: This randomized clinical trial included thirty subjects allocated into two groups: AMPS (15 subjects with PD) and AMPS SHAM (15 subjects with PD). Fourteen age-matched healthy subjects were also included as a REFERENCE group...
January 5, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29243004/altered-effective-connectivity-contributes-to-micrographia-in-patients-with-parkinson-s-disease-and-freezing-of-gait
#15
Evelien Nackaerts, Alice Nieuwboer, Sanne Broeder, Stephan Swinnen, Wim Vandenberghe, Elke Heremans
Recently, it was shown that patients with Parkinson's disease (PD) and freezing of gait (FOG) can also experience freezing episodes during handwriting and present writing problems outside these episodes. So far, the neural networks underlying increased handwriting problems in subjects with FOG are unclear. This study used dynamic causal modeling of fMRI data to investigate neural network dynamics underlying freezing-related handwriting problems and how these networks changed in response to visual cues. Twenty-seven non-freezers and ten freezers performed a pre-writing task with and without visual cues in the scanner with their right hand...
December 14, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29198058/analyzing-gait-variability-and-dual-task-interference-in-patients-with-parkinson-s-disease-and-freezing-by-means-of-the-word-color-stroop-test
#16
Ana Francisca Rozin Kleiner, Aline S Pagnussat, Giulia di Prisco, Alessandro Vagnini, Fabrizio Stocchi, Maria Francesca De Pandis, Manuela Galli
The ability to carry out two tasks at once is critical to effective functioning in the real world and deficits are termed Dual-task interference or effect-DTE. DTE substantially compromised the gait of subjects with Parkinson's disease and freezing of gait (PD + FOG), leading to exaggerated slowing, increasing gait dysrhythmicity, and inducing FOG episodes. This study aimed to investigate the DTE in gait variability of subjects with PD and freezing of gait (PD + FOG). Thirty-three patients with PD + FOG and 14 healthy individuals (REFERENCE) took part at this study...
December 2, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29196699/altered-resting-state-brain-activity-in-parkinson-s-disease-patients-with-freezing-of-gait
#17
Tao-Mian Mi, Shan-Shan Mei, Pei-Peng Liang, Lin-Lin Gao, Kun-Cheng Li, Tao Wu, Piu Chan
Freezing of gait (FOG) is a common and debilitating symptom in Parkinson's disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150872/predicting-the-onset-of-freezing-of-gait-a-longitudinal-study
#18
Kaylena A Ehgoetz Martens, Emily L Lukasik, Matthew J Georgiades, Moran Gilat, Julie M Hall, Courtney C Walton, Simon J G Lewis
BACKGROUND: Freezing of gait is a disabling symptom of Parkinson's disease that ultimately affects approximately 80% of patients, yet very little research has focused on predicting the onset of freezing of gait and tracking the longitudinal progression of symptoms prior to its onset. The objective of the current study was to examine longitudinal data spanning the transition period when patients with PD developed freezing of gait to identify symptoms that may precede freezing and create a prediction model that identifies those "at risk" for developing freezing of gait in the year to follow...
November 18, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29148136/effects-of-sensitive-electrical-stimulation-based-somatosensory-cueing-in-parkinson-s-disease-gait-and-freezing-of-gait-assessment
#19
Benoît Sijobert, Christine Azevedo, David Andreu, Claudia Verna, Christian Geny
This study aims to investigate the effect of a somatosensory cueing on gait disorders in subjects with Parkinson's disease (PD). After having performed stepping in place and timed up and go assessing tasks, 13 participants with PD were equipped with an electrical stimulator and an inertial measurement unit (IMU) located under the lateral malleolus on the sagittal plane. Electrodes were positioned under the arch of the foot and electrical stimulation (ES) parameters (five 500 µs/phase charge-balanced biphasic pulses delivered at 200 Hz, repeated four times at 10 Hz) adjusted to deliver a sensitive signal...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29137009/brain-metabolism-in-patients-with-freezing-of-gait-after-hypoxic-ischemic-brain-injury-a-pilot-study
#20
Seo Yeon Yoon, Sang Chul Lee, Na Young Kim, Young-Sil An, Yong Wook Kim
Movement disorders are 1 of the long-term neurological complications that can occur after hypoxic-ischemic brain injury (HIBI). However, freezing of gait (FOG) after HIBI is rare. The aim of this study was to examine the brain metabolism of patients with FOG after HIBI using F-18 fluoro-2-deoxy-D-glucose positron emission tomography (F-18 FDG PET).We consecutively enrolled 11 patients with FOG after HIBI. The patients' overall brain metabolism was measured by F-18 FDG PET, and we compared their regional brain metabolic activity with that from 15 healthy controls using a voxel-by-voxel-based statistical mapping analysis...
November 2017: Medicine (Baltimore)
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