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Freezing of gait

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https://www.readbyqxmd.com/read/29648576/life-space-mobility-in-parkinson-s-disease-associations-with-motor-and-non-motor-symptoms
#1
Merja Rantakokko, Susanne Iwarsson, Björn Slaug, Maria H Nilsson
Background: To describe life-space mobility and explore associations of motor and non-motor symptoms with life-space mobility in people with Parkinson's disease (PD). Methods: 164 community-dwelling persons with PD (mean age 71.6 years, 64.6% men) received a postal survey and a subsequent home visit. Motor assessments included perceived walking difficulties (Walk-12G), mobility (Timed Up and Go test), motor symptoms (UPDRS-III) and freezing of gait (item 3, FOG-Qsa)...
April 10, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29643593/characteristics-associated-with-freezing-of-gait-in-actual-daily-living-in-parkinson-s-disease
#2
Mitsuaki Ishii, Kohei Okuyama
[Purpose] Parkinson's disease (PD) patients often freeze in actual daily living but seldom in clinical setting. This study aimed to identify the factors contributing to freezing of gait (FOG). [Subjects and Methods] The participants included 28 adults with PD. Principal component analysis was used to investigate the characteristics of 14 common FOG situations adopted from previous studies. Cluster analysis classified the subjects into four groups. Kruskal-Wallis test was performed to compare the PD Questionnaire-39 mobility dimension between the groups...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29629527/an-8-week-low-intensity-progressive-cycling-training-improves-motor-functions-in-patients-with-early-stage-parkinson-s-disease
#3
Hsiu Chen Chang, Chin Song Lu, Wei Da Chiou, Chiung Chu Chen, Yi Hsin Weng, Ya Ju Chang
BACKGROUND AND PURPOSE: The effects of high-intensity cycling as an adjuvant therapy for early-stage Parkinson's disease (PD) were highlighted recently. However, patients experience difficulties in maintaining these cycling training programs. The present study investigated the efficacy of cycling at a mild-to-moderate intensity in early-stage PD. METHODS: Thirteen PD patients were enrolled for 16 serial cycling sessions over a 2-month period. Motor function was assessed using the Unified Parkinson's Disease Rating Scale part III (UPDRS III) and Timed Up and Go (TUG) test as primary outcomes...
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29623988/levodopa-carbidopa-intestinal-gel-is-the-naso-jejunal-phase-a-redundant-convention
#4
Nirosen Vijiaratnam, Sarah Hewer, Sue Varley, Eldho Paul, Kelly L Bertram, Will Lee, Matthew Ligtermoet, David R Williams
Levodopa-carbidopa intestinal gel (LCIG) is an effective treatment for Parkinson disease. Initiating therapy involves an initial naso-jejunal (NJ) titration phase. The NJ phase is prolonged with significant morbidity. The aim of this study is to assess the impact of proceeding without the NJ phase on resource utilisation and the outcomes of patients. Twenty-five patients were started on LCIG using the patients existing levodopa equivalent dose (LED). We recorded change in LED, length of hospital stay, readmission rates and use of outpatient services and clinical outcomes within 6 months...
April 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29621320/medication-and-trial-duration-influence-postural-and-pointing-parameters-during-a-standing-repetitive-pointing-task-in-individuals-with-parkinson-s-disease
#5
Deborah A Jehu, Hiram Cantù, Allen Hill, Caroline Paquette, Julie N Côté, Julie Nantel
We aimed to determine the effects of levodopa medication on the performance of a repetitive pointing task while standing, and to investigate the optimal trial duration in individuals with Parkinson's disease, and older adults. Seventeen individuals with Parkinson's disease (5 freezers) and 9 older adults stood on force platforms for 30 s and 120 s while performing a bilateral repetitive pointing task, tracked by motion capture. Participants with Parkinson's disease were assessed on and off medication and older adults were also assessed on separate days...
2018: PloS One
https://www.readbyqxmd.com/read/29616302/alterations-in-white-matter-network-topology-contribute-to-freezing-of-gait-in-parkinson-s-disease
#6
Julie M Hall, James M Shine, Kaylena A Ehgoetz Martens, Moran Gilat, Kathryn M Broadhouse, Jennifer Y Y Szeto, Courtney C Walton, Ahmed A Moustafa, Simon J G Lewis
Freezing of gait (FOG) is a common symptom in advanced Parkinson's disease (PD). Despite current advances, the neural mechanisms underpinning this disturbance remain poorly understood. To this end, we investigated the structural organisation of the white matter connectome in PD freezers and PD non-freezers. We hypothesized that freezers would show an altered network architecture, which could hinder the effective information processing that characterizes the disorder. Twenty-six freezers and twenty-four well-matched non-freezers were included in this study...
April 3, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29606604/predictors-of-camptocormia-in-patients-with-parkinson-s-disease-a-prospective-study-from-southwest-china
#7
Ruwei Ou, Hui Liu, Yanbing Hou, Wei Song, Bei Cao, Qianqian Wei, Xiaoqin Yuan, Yongping Chen, Bi Zhao, Huifang Shang
BACKGROUND: Camptocormia is becoming increasingly recognized as a prominent phenomenon in Parkinson's disease (PD). OBJECTIVE: This study aims to investigate the clinical predictors of future camptocormia in a cohort of PD patients. METHODS: A total of 263 PD patients without camptocormia were prospectively monitored for approximately 3 years. The end-point was the occurrence of camptocormia. RESULTS: Overall, camptocormia was observed in 23 patients (8...
March 27, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29602542/decreased-interhemispheric-homotopic-connectivity-in-parkinson-s-disease-patients-with-freezing-of-gait-a-resting-state-fmri-study
#8
Junyi Li, Yongsheng Yuan, Min Wang, Jiejin Zhang, Li Zhang, Siming Jiang, Xixi Wang, Jian Ding, Kezhong Zhang
INTRODUCTION: Freezing of gait is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of freezing of gait in PD remain uncertain. Existing studies on PD patients with freezing of gait (PD-FOG+) have reported damage of the corpus callosum, the largest commissural bundle of the brain. Thus, in this study we explored homotopic connectivity to investigate FOG-related interehemispheric alterations METHODS: A total of 21 PD-FOG + patients, 33 PD patients without freezing of gait (PD-FOG-), and 24 matched healthy controls were recruited...
March 26, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29577677/phase-determination-using-chromosomal-microarray-and-fluorescence-in-situ-hybridization-in-a-patient-with-early-onset-parkinson-disease-and-two-deletions-in-prkn
#9
Eli S Williams, Matthew J Barrett, Radhika Dhamija, Lisa Toran, Chelsea Chambers, Mani S Mahadevan, Wendy L Golden
BACKGROUND: Mutations in the parkin gene (PRKN) are the most commonly identified genetic factors in early onset Parkinson disease (EOPD), with biallelic mutations, resulting in a clinical phenotype. However, normal variation is also common in PRKN, particularly in the form of copy number variation (CNV), challenging interpretation of genetic testing results. Here we report a case of a 29-year-old male with EOPD and two deletions in PRKN detected by chromosomal microarray (CMA). METHODS: The proband was clinically examined by a neurologist for postural instability with frequent falls, bradykinesia, gait freezing with festination, and hypophonia...
March 25, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29572571/exploring-the-relationship-between-motor-impairment-vascular-burden-and-cognition-in-parkinson-s-disease
#10
Tanja Stojkovic, Elka Stefanova, Ivan Soldatovic, Vladana Markovic, Iva Stankovic, Igor Petrovic, Federica Agosta, Sebastiano Galantucci, Massimo Filippi, Vladimir Kostic
OBJECTIVE: To determine frequency and type of cognitive disorders in cross-sectional analysis of a Parkinson's disease (PD) cohort, and explore its relations to motor symptoms, modifiable vascular risk factors and white matter lesions (WML) volume. METHODS: In a group of 133 PD patients, mild cognitive impairment (PD-MCI) and dementia (PDD) were diagnosed according to Movement Disorders Society Task Force criteria (level 2 for PD-MCI). Detailed motor measurements were applied, including rigidity, axial, bradykinesia, tremor and postural instability gait disorders (PIGD) scores...
March 23, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29571872/alterations-of-regional-homogeneity-in-freezing-of-gait-in-parkinson-s-disease
#11
Caihong Zhou, Xiaoling Zhong, Yongzhe Yang, Wanqun Yang, Lijuan Wang, Yuhu Zhang, Kun Nie, Jianmin Xu, Biao Huang
INTRODUCTION: Freezing of gait (FOG) is a serious complication in patients with Parkinson's disease (PD), and is more common in the late state of the disease. The high risk of falling in patients with FOG impacts their quality of life. OBJECTIVE: To explore altered neuroactivity related to cognitive and executive function of PD patients with FOG. METHODS: Fourteen PD patients with FOG (FOG+), 20 PD patients without FOG (FOG-), and 18 normal controls (NC) were enrolled...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29571090/impaired-set-shifting-is-associated-with-previous-falls-in-individuals-with-and-without-parkinson-s-disease
#12
J Lucas McKay, Kimberly C Lang, Lena H Ting, Madeleine E Hackney
BACKGROUND: Individuals with Parkinson's disease (PD) are at increased risk for falls, which lead to substantial morbidity and mortality. Understanding the motor and non-motor impairments associated with falls in PD is critical to informing prevention strategies. In addition to motor symptoms, individuals with PD exhibit non-motor deficits, including impaired set shifting, an aspect of executive function related to cognitive flexibility that can be measured quickly with the Trailmaking Test...
March 6, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29554851/the-impact-of-dual-tasking-on-postural-stability-in-people-with-parkinson-s-disease-with-and-without-freezing-of-gait
#13
Esther M J Bekkers, Kim Dockx, Surendar Devan, Sam Van Rossom, Sabine M P Verschueren, Bastiaan R Bloem, Alice Nieuwboer
BACKGROUND: Postural instability and freezing of gait (FOG) are major problems in patients with Parkinson's disease (PD), and both contribute to falls. However, the interrelationship between these 2 deficits is still unclear. OBJECTIVE: This study investigated whether dual-tasking influenced postural control differently in freezers (FOG+) and nonfreezers (FOG-). METHODS: Thirty-three patients with PD (19 FOG+, 14 FOG-, well-matched) and 28 healthy controls underwent 4 postural control tasks, consisting of standing on either stable or unstable surfaces with eyes open or closed...
February 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29550375/freezing-of-gait-promising-avenues-for-future-treatment
#14
REVIEW
Moran Gilat, Ana Lígia Silva de Lima, Bastiaan R Bloem, James M Shine, Jorik Nonnekes, Simon J G Lewis
Freezing of gait is a devastating symptom of Parkinson's disease and other forms of parkinsonism. It poses a major burden on both patients and their families, as freezing often leads to falls, fall-related injuries and a loss of independence. Treating freezing of gait is difficult for a variety of reasons: it has a paroxysmal and unpredictable nature; a multifaceted pathophysiology, with an interplay between motor elements (disturbed stepping mechanisms) and non-motor elements (cognitive decline, anxiety); and a complex (and likely heterogeneous) underlying neural substrate, involving multiple failing neural networks...
March 12, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29541542/predictors-of-freezing-of-gait-in-chinese-patients-with-parkinson-s-disease
#15
Ruwei Ou, Qianqian Wei, Bei Cao, Wei Song, Yanbing Hou, Hui Liu, Xiaoqin Yuan, Bi Zhao, Ying Wu, Huifang Shang
Objective: To explore the clinical predictors of freezing of gait (FOG) in Chinese patients with Parkinson's disease (PD). Methods: This study included 225 patients with PD who completed a three-year follow-up visit. The end-point was the presence of FOG (freezers), which was assessed during the follow-up visit. Group comparisons were conducted, followed by a further forward binary logistic regression analysis. Results: Eighty-five patients with PD (38%) had developed FOG at the end of study...
March 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29541016/galvanic-vestibular-stimulation-gvs-augments-deficient-pedunculopontine-nucleus-ppn-connectivity-in-mild-parkinson-s-disease-fmri-effects-of-different-stimuli
#16
Jiayue Cai, Soojin Lee, Fang Ba, Saurabh Garg, Laura J Kim, Aiping Liu, Diana Kim, Z Jane Wang, Martin J McKeown
Falls and balance difficulties remain a major source of morbidity in Parkinson's Disease (PD) and are stubbornly resistant to therapeutic interventions. The mechanisms of gait impairment in PD are incompletely understood but may involve changes in the Pedunculopontine Nucleus (PPN) and its associated connections. We utilized fMRI to explore the modulation of PPN connectivity by Galvanic Vestibular Stimulation (GVS) in healthy controls ( n = 12) and PD subjects even without overt evidence of Freezing of Gait (FOG) while on medication ( n = 23)...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29540785/author-correction-altered-resting-state-brain-activity-in-parkinson-s-disease-patients-with-freezing-of-gait
#17
Tao-Mian Mi, Shan-Shan Mei, Pei-Peng Liang, Lin-Lin Gao, Kun-Cheng Li, Tao Wu, Piu Chan
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29523394/presynaptic-striatal-dopaminergic-depletion-predicts-the-later-development-of-freezing-of-gait-in-de-novo-parkinson-s-disease-an-analysis-of-the-ppmi-cohort
#18
Ryul Kim, Joongyub Lee, Yoon Kim, Aryun Kim, Mihee Jang, Han-Joon Kim, Beomseok Jeon, Un Jung Kang, Stanley Fahn
INTRODUCTION: The current study was designed to determine whether the degree of presynaptic striatal dopamine depletion can predict the later development of freezing of gait (FOG) in Parkinson's disease (PD). METHODS: This retrospective cohort study included 390 de novo patients with PD without FOG at baseline. The participants were divided into tertiles according to the baseline dopamine transporter (DAT) uptake of each striatal subregion, and the cumulative risk of FOG was compared using the Kaplan-Meier method...
February 28, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29507265/prediction-of-freezing-of-gait-in-patients-with-parkinson-s-disease-using-eeg-signals
#19
A M Ardi Handojoseno, Ganesh R Naik, Moran Gilat, James M Shine, Tuan N Nguyen, Quynh T Ly, Simon J G Lewis, Hung T Nguyen
Freezing of gait (FOG) is an episodic gait disturbance affecting initiation and continuation of locomotion in many Parkinson's disease (PD) patients, causing falls and a poor quality of life. FOG can be experienced on turning and start hesitation, passing through doorways or crowded areas dual tasking, and in stressful situations. Electroencephalography (EEG) offers an innovative technique that may be able to effectively foresee an impending FOG. From data of 16 PD patients, using directed transfer function (DTF) and independent component analysis (ICA) as data pre-processing, and an optimal Bayesian neural network as a predictor of a transition of 5 seconds before the impending FOG occurs in 11 in-group PD patients, we achieved sensitivity and specificity of 85...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29503606/deep-brain-stimulation-to-alleviate-freezing-of-gait-and-cognitive-dysfunction-in-parkinson-s-disease-update-on-current-research-and-future-perspectives
#20
REVIEW
Chuyi Huang, Heling Chu, Yan Zhang, Xiaoping Wang
Freezing of gait (FOG) is a gait disorder featured by recurrent episodes of temporary gait halting and mainly found in advanced Parkinson's disease (PD). FOG has a severe impact on the quality of life of patients with PD. The pathogenesis of FOG is unclear and considered to be related to several brain areas and neural circuits. Its close connection with cognitive disorder has been proposed and some researchers explain the pathogenesis using the cognitive model theory. FOG occurs concurrently with cognitive disorder in some PD patients, who are poorly responsive to medication therapy...
2018: Frontiers in Neuroscience
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