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https://www.readbyqxmd.com/read/29031781/the-effectiveness-of-istradefylline-for-the-treatment-of-gait-deficits-and-sleepiness-in-patients-with-parkinson-s-disease
#1
Keita Matsuura, Hiroyuki Kajikawa, Ken-Ichi Tabei, Masayuki Satoh, Hirotaka Kida, Naoko Nakamura, Hidekazu Tomimoto
PURPOSE: Istradefylline is useful in treating the wearing-off state in Parkinson's disease (PD). We investigated the effectiveness of istradefylline (ISD) in improving arousal, sleep, and gait deficits in patients with PD. METHODS: We examined 14 patients with PD treated with ISD. We assessed the patients using the Unified Parkinson's Disease Rating Scale, Parkinson's Disease Questionnaire, Timed Up-and-Go test (TUG), Freezing of Gait Questionnaire (FOG-Q), Epworth Sleepiness Scale (ESS), and Parkinson's Disease Sleep Scale (PDSS) before and 1 month after ISD use...
October 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28991672/clinical-profiles-associated-with-lrrk2-and-gba-mutations-in-brazilians-with-parkinson-s-disease
#2
Camilla P da Silva, Gabriella de M Abreu, Pedro H Cabello Acero, Mário Campos, João S Pereira, Sarah R de A Ramos, Caroline M Nascimento, Danielle D Voigt, Ana Lucia Rosso, Marco A Araujo Leite, Luiz Felipe R Vasconcellos, Denise H Nicaretta, Marcus V Della Coletta, Delson José da Silva, Andressa P Gonçalves, Jussara M Dos Santos, Veluma Calassara, Débora Cristina T Valença, Cyro J de M Martins, Cíntia B Santos-Rebouças, Márcia M G Pimentel
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder characterized by remarkable phenotypic variability. Accumulated evidence points that the manifestation of PD clinical signs might be differentially modified by genetic factors, as mutations in LRRK2 and GBA genes. In this sense, the clarification of the genotype-phenotype correlations in PD has important implications in predicting prognosis and can contribute to the development of specific therapeutic approaches. METHODS: Here, we conducted the first comparative analysis of motor and non-motor features in 17 LRRK2 and 22 GBA mutation carriers and 93 non-carriers unrelated PD patients from Brazil, a highly admixed population...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28987182/tauopathies
#3
Gabor G Kovacs
Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain. The spectrum of tau pathologies expands beyond the traditionally discussed disease forms like Pick disease, progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease. Emerging entities and pathologies include globular glial tauopathies, primary age-related tauopathy, which includes neurofibrillary tangle dementia, chronic traumatic encephalopathy (CTE), and aging-related tau astrogliopathy...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28980176/effects-of-dance-practice-on-functional-mobility-motor-symptoms-and-quality-of-life-in-people-with-parkinson-s-disease-a-systematic-review-with-meta-analysis
#4
REVIEW
Marcela Dos Santos Delabary, Isabel Giovannini Komeroski, Elren Passos Monteiro, Rochelle Rocha Costa, Aline Nogueira Haas
BACKGROUND: Patients with Parkinson's Disease (PD) undergo motor injuries, which decrease their quality of life (QL). Dance, added to drug therapy, can help treating these patients AIMS: To conduct a systematic review with meta-analysis with the aim to analyze the effects of dance classes in comparison to other interventions or to the absence of intervention, in randomized clinical trials (RCTs), on functional mobility, motor symptoms and QL of PD patients METHODS: The search was conducted in MEDLINE, LILACS, SciELO, Cochrane and PsycINFO (last searched in August 2017)...
October 4, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28963889/a-holter-for-parkinson-s-disease-validation-of-the-ability-to-detect-on-off-states-using-the-rempark-system
#5
Àngels Bayés, Albert Samá, Anna Prats, Carlos Pérez-López, Maricruz Crespo-Maraver, Juan Manuel Moreno, Sheila Alcaine, Alejandro Rodriguez-Molinero, Berta Mestre, Paola Quispe, Ana Correia de Barros, Rui Castro, Alberto Costa, Roberta Annicchiarico, Patrick Browne, Tim Counihan, Hadas Lewy, Gabriel Vainstein, Leo R Quinlan, Dean Sweeney, Gearóid ÓLaighin, Jordi Rovira, Daniel Rodrigue Z-Martin, Joan Cabestany
The treatment of Parkinson's disease (PD) with levodopa is very effective. However, over time, motor complications (MCs) appear, restricting the patient from leading a normal life. One of the most disabling MCs is ON-OFF fluctuations. Gathering accurate information about the clinical status of the patient is essential for planning treatment and assessing its effect. Systems such as the REMPARK system, capable of accurately and reliably monitoring ON-OFF fluctuations, are of great interest. OBJECTIVE: To analyze the ability of the REMPARK System to detect ON-OFF fluctuations...
September 25, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28960543/pedunculopontine-nucleus-deep-brain-stimulation-in-parkinson-s-disease-a-clinical-review
#6
REVIEW
Wesley Thevathasan, Bettina Debu, Tipu Aziz, Bastiaan R Bloem, Christian Blahak, Christopher Butson, Virginie Czernecki, Thomas Foltynie, Valerie Fraix, David Grabli, Carole Joint, Andres M Lozano, Michael S Okun, Jill Ostrem, Nicola Pavese, Christoph Schrader, Chun-Hwei Tai, Joachim K Krauss, Elena Moro
Pedunculopontine nucleus region deep brain stimulation (DBS) is a promising but experimental therapy for axial motor deficits in Parkinson's disease (PD), particularly gait freezing and falls. Here, we summarise the clinical application and outcomes reported during the past 10 years. The published dataset is limited, comprising fewer than 100 cases. Furthermore, there is great variability in clinical methodology between and within surgical centers. The most common indication has been severe medication refractory gait freezing (often associated with postural instability)...
September 28, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28951429/chronic-subdural-haematoma-presenting-as-freezing-of-gait
#7
Kazuyuki Noda, Nobutaka Hattori, Yasuyuki Okuma, Takuji Yamamoto
In this report, we describe a case of freezing of gait (FOG) in a patient with chronic subdural haematoma (CSDH). An 81-year-old patient presented with progressive FOG about 6 weeks after a minor head trauma. MRI revealed CSDH in the left hemisphere, resulting in a marked compression of the hemisphere. His FOG disappeared after neurosurgical evacuation of the haematoma. It is suggested that the subdural haematoma in his left frontal cortices caused FOG. CSDH should be considered as a differential diagnosis when FOG develops after a head trauma in elderly patients, and prompt evaluations including neuroimaging and timely neurosurgical intervention are required...
September 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28928491/freezing-of-gait-is-associated-with-cortical-thinning-in-mesial-frontal-cortex
#8
Miroslav Vastik, Pavel Hok, Jan Valosek, Petr Hlustik, Katerina Mensikova, Petr Kanovsky
AIMS: The relationship between freezing of gait (FOG) and regional brain atrophy has been intensively investigated, but it is still not clearly understood. The study objective was to test whether grey matter (GM) atrophy contributes to FOG in Parkinson´s disease (PD) using a surface-based algorithm. METHODS: We investigated 21 patients with PD, 11 with FOG and 10 without FOG. Both groups were assessed using a FOG questionnaire and Hoehn and Yahr staging. High resolution T1-weighted brain images were acquired for each subject using a 1...
September 13, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28927894/freezing-related-perception-deficits-of-asymmetrical-walking-in-parkinson-s-disease
#9
Esther M J Bekkers, Wouter Hoogkamer, Aniek Bengevoord, Elke Heremans, Sabine M P Verschueren, Alice Nieuwboer
Patients with Parkinson's disease (PD), and especially those with freezing of gait (FOG), are known to experience impairments in gait rhythmicity, symmetry, and bilateral coordination between both legs. In the current study, we investigated whether deficits in perception of gait speed between limbs were more pronounced in freezers than in non-freezers and could explain some of these gait impairments. We also assessed cognitive ability and proprioception. Twenty-five PD patients (13 freezers, 12 non-freezers) and 12 healthy controls walked on a split-belt treadmill, while the speed of one of the belts was gradually increased...
September 18, 2017: Neuroscience
https://www.readbyqxmd.com/read/28892573/bicycling-suppresses-abnormal-beta-synchrony-in-the-parkinsonian-basal-ganglia
#10
Lena Storzer, Markus Butz, Jan Hirschmann, Omid Abbasi, Maciej Gratkowski, Dietmar Saupe, Jan Vesper, Sarang S Dalal, Alfons Schnitzler
OBJECTIVE: Freezing of gait is a poorly understood symptom of Parkinson disease, and can severely disrupt the locomotion of affected patients. However, bicycling ability remains surprisingly unaffected in most patients suffering from freezing, suggesting functional differences in the motor network. The purpose of this study was to characterize and contrast the oscillatory dynamics underlying bicycling and walking in the basal ganglia. METHODS: We present the first local field potential recordings directly comparing bicycling and walking in Parkinson disease patients with electrodes implanted in the subthalamic nuclei for deep brain stimulation...
September 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28890341/cueing-for-people-with-parkinson-s-disease-with-freezing-of-gait-a-narrative-review-of-the-state-of-the-art-and-novel-perspectives
#11
REVIEW
Ginis Pieter, Nackaerts Evelien, Nieuwboer Alice, Heremans Elke
Freezing, which manifests during gait and other movements, is an incapacitating motor symptom experienced by many patients with Parkinson's disease (PD). In rehabilitation, auditory and visual cueing methods are commonly applied to evoke a more goal-directed type of motor control and, as such, reduce freezing severity in patients with PD. In this narrative review, we summarize the current evidence regarding the effects of external cueing in patients with PD with freezing of gait (FOG) and provide suggestions on how to further improve cueing effectiveness with emerging technological developments...
September 7, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28890315/subthalamic-neural-entropy-is-a-feature-of-freezing-of-gait-in-freely-moving-people-with-parkinson-s-disease
#12
Judy Syrkin-Nikolau, Mandy Miller Koop, Thomas Prieto, Chioma Anidi, Muhammad Furqan Afzal, Anca Velisar, Zack Blumenfeld, Talora Martin, Megan Trager, Helen Bronte-Stewart
The goal of this study was to investigate subthalamic (STN) neural features of Freezers and Non-Freezers with Parkinson's disease (PD), while freely walking without freezing of gait (FOG) and during periods of FOG, which were better elicited during a novel turning and barrier gait task than during forward walking. METHODS: Synchronous STN local field potentials (LFPs), shank angular velocities, and ground reaction forces were measured in fourteen PD subjects (eight Freezers) off medication, OFF deep brain stimulation (DBS), using an investigative, implanted, sensing neurostimulator (Activa® PC+S, Medtronic, Inc...
September 7, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28886015/freezing-during-tapping-tasks-in-patients-with-advanced-parkinson-s-disease-and-freezing-of-gait
#13
Arnaud Delval, Luc Defebvre, Céline Tard
INTRODUCTION: Parkinson's disease patients with freezing of gait also experience sudden motor blocks (freezing) during other repetitive motor tasks. We assessed the proportion of patients with advanced PD and freezing of gait who also displayed segmental "freezing" in tapping tasks. METHODS: Fifteen Parkinson's disease patients with freezing of gait were assessed. Freezing of gait was evaluated using a standardized gait trajectory with the usual triggers. Patients performed repetitive tapping movements (as described in the MDS-UPDRS task) with the hands or the feet in the presence or absence of a metronome set to 4 Hz...
2017: PloS One
https://www.readbyqxmd.com/read/28862245/novel-use-of-levodopa-in-human-immunodeficiency-virus-encephalopathy-mediated-parkinsonism-in-an-adult
#14
M F Devine, C Herrin, W Warnack, D Dubey
We report a case of a 36-year-old man with a medical history of human immunodeficiency virus (HIV) infection who presented with hypomimia, hypophonia, bradykinesia, rigidity, and freezing of gait. His clinical presentation and magnetic resonance imaging were consistent with HIV encephalopathy with involvement of the bilateral basal ganglia and diffuse leukoencephalopathy. We initiated a trial of carbidopa-levodopa. The dose was escalated to 1050 mg levodopa daily. Amantadine was also started. The patient was closely monitored for behavioral, neurological, or systemic side effects...
August 31, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28858631/near-falls-in-people-with-parkinson-s-disease-circumstances-contributing-factors-and-association-with-falling
#15
Tatjana Gazibara, Darija Kisic Tepavcevic, Marina Svetel, Aleksandra Tomic, Iva Stankovic, Vladimir S Kostic, Tatjana Pekmezovic
OBJECTIVES: To describe circumstances of near-falls among persons with Parkinson's disease (PD), assess factors associated with near-falling and assess whether near-falls in the first 6 months are associated with falling in the latter 6 months over one year of follow-up. MATERIALS AND METHODS: In the period August 2011-December 2012, 120 consecutive persons with PD, who denied having fallen in the past 6 months, were recruited at Clinical center of Serbia in Belgrade...
October 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28855889/l-dopa-and-freezing-of-gait-in-parkinson-s-disease-objective-assessment-through-a-wearable-wireless-system
#16
Antonio Suppa, Ardian Kita, Giorgio Leodori, Alessandro Zampogna, Ettore Nicolini, Paolo Lorenzi, Rosario Rao, Fernanda Irrera
Freezing of gait (FOG) is a leading cause of falls and fractures in Parkinson's disease (PD). The episodic and rather unpredictable occurrence of FOG, coupled with the variable response to l-DOPA of this gait disorder, makes the objective evaluation of FOG severity a major clinical challenge in the therapeutic management of patients with PD. The aim of this study was to examine and compare gait, clinically and objectively, in patients with PD, with and without FOG, by means of a new wearable system. We also assessed the effect of l-DOPA on FOG severity and specific spatiotemporal gait parameters in patients with and without FOG...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28855887/identification-of-characteristic-motor-patterns-preceding-freezing-of-gait-in-parkinson-s-disease-using-wearable-sensors
#17
Luca Palmerini, Laura Rocchi, Sinziana Mazilu, Eran Gazit, Jeffrey M Hausdorff, Lorenzo Chiari
Freezing of gait (FOG) is a disabling symptom that is common among patients with advanced Parkinson's disease (PD). External cues such as rhythmic auditory stimulation can help PD patients experiencing freezing to resume walking. Wearable systems for automatic freezing detection have been recently developed. However, these systems detect a FOG episode after it has happened. Instead, in this study, a new approach for the prediction of FOG (before it actually happens) is presented. Prediction of FOG might enable preventive cueing, reducing the likelihood that FOG will occur...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28852579/predictors-of-functional-and-quality-of-life-outcomes-following-deep-brain-stimulation-surgery-in-parkinson-s-disease-patients-disease-patient-and-surgical-factors
#18
Hesham Abboud, Gencer Genc, Nicolas R Thompson, Srivadee Oravivattanakul, Faisal Alsallom, Dennys Reyes, Kathy Wilson, Russell Cerejo, Xin Xin Yu, Darlene Floden, Anwar Ahmed, Michal Gostkowski, Ayman Ezzeldin, Hazem Marouf, Ossama Y Mansour, Andre Machado, Hubert H Fernandez
OBJECTIVE: The primary objective was to evaluate predictors of quality of life (QOL) and functional outcomes following deep brain stimulation (DBS) in Parkinson's disease (PD) patients. The secondary objective was to identify predictors of global improvement. METHODS: PD patients who underwent DBS at our Center from 2006 to 2011 were evaluated by chart review and email/phone survey. Postoperative UPDRS II and EQ-5D were analyzed using simple linear regression adjusting for preoperative score...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28837826/botulinum-toxin-in-parkinsonism-the-when-how-and-which-for-botulinum-toxin-injections
#19
Francisco Cardoso
The aim of this article is to provide a review of the use of injections of botulinum toxin in the management of selected symptoms and signs of Parkinson's disease and other forms of parkinsonism. Sialorrhea is defined as inability to control oral secretions, resulting in excessive saliva in the oropharynx. There is a high level of evidence for the treatment of sialorrhea in parkinsonism with injections of different forms of botulinum toxin type A as well as botulinum toxin type B. Tremor can be improved by the use of botulinum toxin injections but improved tremor control often leads to concomitant motor weakness, limiting its use...
August 23, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28830666/depression-may-negatively-affect-the-change-in-freezing-of-gait-following-subthalamic-nucleus-stimulation-in-parkinson-s-disease
#20
Ryul Kim, Han-Joon Kim, Aryun Kim, Yoon Kim, Ah-Ro Kim, Chae-Won Shin, Sun Ha Paek, Beomseok Jeon
OBJECTIVE: To assess the influence of preoperative depression on the change in freezing of gait (FOG) following subthalamic nucleus stimulation (STN-DBS) in patients with Parkinson's disease (PD). METHODS: One hundred and twelve PD patients were included who received bilateral STN-DBS. Of these, 33 had no preoperative depression (PD-ND) and the other 79 had preoperative depression (PD-D). Each PD-ND patient was matched with one PD-D patient by the propensity score for which sex, age at PD onset, disease duration, UPDRS-III score during off-medication state, levodopa-equivalent daily dose, and mini mental state examination were the independent variables...
August 10, 2017: Parkinsonism & related Disorders
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