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https://www.readbyqxmd.com/read/29150746/correlation-between-quantitative-pivot-shift-and-generalized-joint-laxity-a-prospective-multicenter-study-of-acl-ruptures
#1
David Sundemo, Anna Blom, Yuichi Hoshino, Ryosuke Kuroda, Nicola Francesco Lopomo, Stefano Zaffagnini, Volker Musahl, James J Irrgang, Jón Karlsson, Kristian Samuelsson
PURPOSE: To investigate whether an increased magnitude of quantitative rotatory knee laxity is associated with a greater level of generalized joint laxity in ACL-injured and contralateral knees. METHODS: A total of 103 patients were enrolled across four international centers to undergo anatomic ACL reconstruction. Rotatory knee laxity was evaluated preoperatively, both in the awake state and under anesthesia, using the standardized pivot shift test. Two devices were used to quantify rotatory knee laxity; an inertial sensor, measuring the joint acceleration, and an image analysis system, measuring the lateral compartment translation of the tibia...
November 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29150344/biomechanical-mechanism-of-lateral-trunk-lean-gait-for-knee-osteoarthritis-patients
#2
Kazuki Tokuda, Masaya Anan, Makoto Takahashi, Tomonori Sawada, Kenji Tanimoto, Nobuhiro Kito, Koichi Shinkoda
The biomechanical mechanism of lateral trunk lean gait employed to reduce external knee adduction moment (KAM) for knee osteoarthritis (OA) patients is not well known. This mechanism may relate to the center of mass (COM) motion. Moreover, lateral trunk lean gait may affect motor control of the COM displacement. Uncontrolled manifold (UCM) analysis is an evaluation index used to understand motor control and variability of the motor task. Here we aimed to clarify the biomechanical mechanism to reduce KAM during lateral trunk lean gait and how motor variability controls the COM displacement...
November 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29149846/the-impact-of-bone-morphology-on-the-outcome-of-the-pivot-shift-test-a-cohort-study
#3
Thomas Branch, Shaun Stinton, Adrija Sharma, Frederic Lavoie, Christian Guier, Philippe Neyret
BACKGROUND: The presence of a positive pivot shift after surgical repair of the ACL is considered an important indicator of a failed reconstruction. The ability to predict the result of a pivot shift test after an ACL reconstruction using variables that can be measured prior to surgery could provide an indication of which patients may be at-risk of a poor surgical outcome.The purpose of this study was to determine whether structural characteristics of the femur and tibia, measured using plain radiographs, were associated with the result of the pivot shift test in unilateral ACL reconstructed patients...
November 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29149840/geometric-morphometrics-reveals-shifts-in-flower-shape-symmetry-and-size-following-gene-knockdown-of-cycloidea-and-anthocyanidin-synthase
#4
Brent A Berger, Vincent A Ricigliano, Yoland Savriama, Aedric Lim, Veronica Thompson, Dianella G Howarth
BACKGROUND: While floral symmetry has traditionally been assessed qualitatively, recent advances in geometric morphometrics have opened up new avenues to specifically quantify flower shape and size using robust multivariate statistical methods. In this study, we examine, for the first time, the ability of geometric morphometrics to detect morphological differences in floral dorsoventral asymmetry following virus-induced gene silencing (VIGS). Using Fedia graciliflora Fisch. & Meyer (Valerianaceae) as a model, corolla shape of untreated flowers was compared using canonical variate analysis to knockdown phenotypes of CYCLOIDEA2A (FgCYC2A), ANTHOCYANIDIN SYNTHASE (FgANS), and empty vector controls...
November 17, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29149044/the-effect-of-hock-injury-laterality-and-lameness-on-lying-behaviors-and-lying-laterality-in-holstein-dairy-cows
#5
Nicole L Eberhart, Peter D Krawczel
Lactating dairy cattle divide their lying equally between their left side and their right side. However, discomfort, such as pregnancy and cannulation, can cause a cow to shift lying side preference. The objective of this study was to determine the effect of lameness and hock injuries on lying behaviors, particularly lying laterality, of lactating dairy cows. Cows from four commercial farms in eastern Croatia that had lying behavior data, health score data, and production records were used in the study. Health scores including hock injuries and locomotion were collected once per cow...
November 17, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29147767/mechanism-of-accommodation-assessed-by-change-in-precisely-registered-ocular-images-associated-with-concurrent-change-in-auto-refraction
#6
Andrzej Grzybowski, Ronald A Schachar, Magdalena Gaca-Wysocka, Ira H Schachar, Farhad Kamangar, Barbara K Pierscionek
PURPOSE: Our purpose was to determine the changes in anterior chamber depth (ACD) and central lens thickness (CLT) during pharmacologically induced accommodation. METHODS: Following pupillary dilation with phenylephrine 10%, baseline auto-refractions and swept-source optical coherence tomographic biometric images (Zeiss IOLMaster 700) were obtained from the right eyes of 25 subjects aged 19 to 24 years. Pilocarpine 4% and phenylephrine 10% were then instilled into these right eyes...
November 16, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29145970/minimally-invasive-posteromedial-percutaneous-plate-osteosynthesis-for-diaphyseal-tibial-fractures-technique-description
#7
Andre Wajnsztejn, Robinson Esteves Santos Pires, Alexandre Leme Godoy Dos Santos, Pedro Jose Labronici, Helio Jorge Alvachian Fernandes, Mario Ferretti
PURPOSE: The aim of this study was to evaluate the feasibility of performing minimally-invasive plate osteosynthesis (MIPO) in tibial fractures using two posteromedial incisions, and to measure the distance between the plate and neurovascular structures. MATERIALS AND METHODS: We performed nine dissections of specimens that were submitted to tibial MIPO with two posteromedial incisions. One locking compression plate (LCP) of 14 to 16 holes was inserted into the submuscular tunnel in a retrograde manner...
October 2017: Injury
https://www.readbyqxmd.com/read/29145467/adenosine-lidocaine-and-mg2-alm-fluid-therapy-attenuates-systemic-inflammation-platelet-dysfunction-and-coagulopathy-after-non-compressible-truncal-hemorrhage
#8
Hayley Letson, Geoffrey Dobson
BACKGROUND: Systemic inflammation and coagulopathy are major drivers of injury progression following hemorrhagic trauma. Our aim was to examine the effect of small-volume 3% NaCl adenosine, lidocaine and Mg2+ (ALM) bolus and 0.9% NaCl/ALM 'drip' on inflammation and coagulation in a rat model of hemorrhagic shock. METHODS: Sprague-Dawley rats (429±4 g) were randomly assigned to: 1) shams, 2) no-treatment, 3) saline-controls, 4) ALM-therapy, and 5) Hextend®. Hemorrhage was induced in anesthetized-ventilated animals by liver resection (60% left lateral lobe and 50% medial lobe)...
2017: PloS One
https://www.readbyqxmd.com/read/29145168/frontal-infraslow-activity-marks-the-motor-spasms-of-anti-lgi1-encephalitis
#9
Richard Wennberg, Claude Steriade, Robert Chen, Danielle Andrade
OBJECTIVE: The clinical and electrographic features of seizures in anti-LGI1 encephalitis are distinct from those seen in other autoimmune encephalitides or non-encephalitic epilepsies. One electroclinical phenomenon specific to the condition consists of lateralized motor spasms, known as faciobrachial dystonic seizures (FBDS). An electrodecremental pattern overriding a "DC shift" has been described as the EEG correlate of these spasms. We sought to further characterize this pre-spasm infraslow activity (ISA)...
October 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29144209/bidirectional-associations-between-body-dissatisfaction-and-depressive-symptoms-from-adolescence-through-early-adulthood
#10
Helen Sharpe, Praveetha Patalay, Tse-Hwei Choo, Melanie Wall, Susan M Mason, Andrea B Goldschmidt, Dianne Neumark-Sztainer
Body dissatisfaction and depressive symptoms are commonly experienced during adolescence and increase the risk of adverse health outcomes, especially eating disorders. However, the dominant temporal associations between these two experiences (i.e., whether one is a risk factor for the other or the two are mutually reinforcing) has yet to be fully explored. We examined the associations between body dissatisfaction and depressive symptoms assessed at baseline and 5- and 10-year follow-up in younger (M age = 12...
November 16, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29143574/investigating-the-preventive-effects-of-baicalin-and-gallocatechin-aginst-glyoxal-induced-cystatin-aggregation
#11
Aamir Sohail, Waseem Feeroze Bhat, Mohammad Furkan, Aaliya Shah, Bilqees Bano
Several mammalian proteins form pathological deposits under nonphysiological conditions that are associated with many degenerative diseases. Protein aggregation is associated with aging, as well as a variety of diseases, including cystic fibrosis, amyotrophic lateral sclerosis (ALS), and hypertrophic cardiomyopathy. There is a lack of any potential anti-amyloidogenic agents and therapeutics till date. Polyphenols have been accredited with myriad biological effects. An analysis of the effects of natural agents like baicalin (BC) and gallocatechin (GC) on aggregation process can open new avenues for the treatment of protein misfolding diseases...
November 16, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29142633/risk-factors-of-delayed-surgical-intervention-after-conservatively-treated-acute-traumatic-subdural-hematoma
#12
Hyungjoo Kwon, Kyu-Sun Choi, Hyeong-Joong Yi, Hyoung-Joon Chun, Young-Jun Lee, Dong-Won Kim
Objective: Acute subdural hematoma (ASDH) is generally considered a condition that should be managed surgically. However, some patients initially receive conservative treatment, a subset of whom require surgical intervention later. This study aimed to evaluate the predictors of delayed surgical intervention in ASDH patients who are initially managed conservatively. Methods: From January 2007 to December 2015, 842 patients diagnosed with ASDH were treated at our institution...
November 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29141678/novel-functions-of-lhx2-and-pax6-in-the-developing-telencephalon-revealed-upon-combined-loss-of-both-genes
#13
Geeta Godbole, Achira Roy, Ashwin S Shetty, Shubha Tole
Patterning of the telencephalic neuroepithelium is a tightly regulated process controlled by transcription factors and signalling molecules. The cortical primordium is flanked by two signalling centres, the hem medially, and the antihem laterally. The hem induces the formation of the hippocampus in adjacent neuroepithelium. Therefore, the position of the hem defines the position of the hippocampus in the brain. The antihem is positioned at the boundary between the dorsal and ventral telencephalon and proposed to provide patterning cues during development...
November 15, 2017: Neural Development
https://www.readbyqxmd.com/read/29138916/lateral-retinaculum-plasty-instead-of-lateral-retinacular-release-with-concomitant-medial-patellofemoral-ligament-reconstruction-can-achieve-better-results-for-patellar-dislocation
#14
Chang Liu, Guman Duan, Yingzhen Niu, Pengkai Cao, Kunpeng Fu, Jinghui Niu, Fei Wang
PURPOSE: To elucidate the outcomes of lateral retinaculum plasty versus lateral retinacular release with concomitant medial patellofemoral ligament (MPFL) reconstruction. METHODS: In a prospective study, 59 patients treated at our institution from 2012 to 2014 were included. The 59 patients were randomly divided into two groups. Group I included 27 patients who underwent lateral retinacular release and MPFL reconstruction. Group II included 32 patients who underwent lateral retinaculum plasty and MPFL reconstruction...
November 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29138790/high-efficiency-single-cell-encapsulation-and-size-selective-capture-of-cells-in-picoliter-droplets-based-on-hydrodynamic-micro-vortices
#15
Gopakumar Kamalakshakurup, Abraham P Lee
Single cell analysis has emerged as a paradigm shift in cell biology to understand the heterogeneity of individual cells in a clone for pathological interrogation. Microfluidic droplet technology is a compelling platform to perform single cell analysis by encapsulating single cells inside picoliter-nanoliter (pL-nL) volume droplets. However, one of the primary challenges for droplet based single cell assays is single cell encapsulation in droplets, currently achieved either randomly, dictated by Poisson statistics, or by hydrodynamic techniques...
November 15, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29137665/treatment-for-lateral-patellar-impingement-syndrome-with-arthroscopic-lateral-patelloplasty-a-bidirectional-cohort-study
#16
Tianhao Wu, Shiyu Tang, Fei Wang
BACKGROUND: Anterior knee pain is one of the most common musculoskeletal complaints of young patients. We notice that some patients had normal femoral trochlear, medial and lateral patellar retinaculum, and special patellar morphology, which resulted in a series of symptoms in the flexion of the knee due to the impingement of the lateral articular surface of the patella with the femur. We firstly termed this pathologic process as lateral patellar impingement syndrome (LPIS). This ambispective cohort study was to explore the curative effect of arthroscopic lateral patelloplasty for early LPIS...
November 14, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29136383/a-combined-td-dft-sos-cis-d-study-of-bophy-derivatives-with-potential-application-in-biosensing
#17
Miguel Ponce-Vargas, Cloé Azarias, Denis Jacquemin, Boris Le Guennic
A set of thirteen BOPHY dyes is studied through a hybrid TD-DFT-SOS-CIS(D) approach accounting for solvent effects, in order to shed light onto the structure-property relationships of these recently developed chromophores. In a first step, we calculate the absorption fluorescence crossing points with refined TD-DFT models considering the influences of both vibrational and solvent contributions. We found that the systematic overestimation of the 0-0 energies is effectively reduced by combining PCM-TD-DFT with a scaled opposite spin-configuration interaction singles with a double correction [SOS-CIS(D)]...
November 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29136015/the-influences-of-walking-running-and-stair-activity-on-knee-articular-cartilage-quantitative-mri-using-t1-rho-and-t2-mapping
#18
Meng Chen, Lin Qiu, Si Shen, Fei Wang, Jing Zhang, Cici Zhang, Sirun Liu
OBJECTIVE: To explore the different influences of walking, running and stair activity on knee articular cartilage with T1 rho and T2 mapping sequences. MATERIALS AND METHODS: MRI (3.0-T) scans of the right knee were performed in twenty-three young healthy adults immediately after 30 minutes of rest, walking, running and stair activity respectively. Articular cartilage was quantitatively assessed based on T1 rho and T2 relaxation times. Analysis of variance for random block design data, bonferroni test and paired samples t tests were performed to estimate the different influences of physiological activities on articular cartilage...
2017: PloS One
https://www.readbyqxmd.com/read/29131307/breastfeeding-weaning-and-dietary-practices-during-the-western-zhou-dynasty-1122-771-bc-at-boyangcheng-anhui-province-china
#19
Yang Xia, Jinglei Zhang, Fei Yu, Hui Zhang, Tingting Wang, Yaowu Hu, Benjamin T Fuller
OBJECTIVES: Here we investigate breastfeeding and weaning practices and adult dietary habits at the Western Zhou Dynasty (1122-771 BC) site of Boyangcheng () located in Anhui Province, China. In addition, we utilize the differences in bone collagen turnover rates between rib and long bones from the same individual to examine past life histories, such as changes in diet or residence. MATERIALS AND METHODS: Bone collagen from both the rib and long bones (either femora or humeri) of 42 individuals was measured for stable isotope ratios of carbon (δ(13) C) and nitrogen (δ(15) N)...
November 13, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29129536/event-boundaries-trigger-rapid-memory-reinstatement-of-the-prior-events-to-promote-their-representation-in-long-term-memory
#20
Ignasi Sols, Sarah DuBrow, Lila Davachi, Lluís Fuentemilla
Although everyday experiences unfold continuously over time, shifts in context, or event boundaries, can influence how those events come to be represented in memory [1-4]. Specifically, mnemonic binding across sequential representations is more challenging at context shifts, such that successful temporal associations are more likely to be formed within than across contexts [1, 2, 5-9]. However, in order to preserve a subjective sense of continuity, it is important that the memory system bridge temporally adjacent events, even if they occur in seemingly distinct contexts...
November 4, 2017: Current Biology: CB
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