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https://www.readbyqxmd.com/read/29774779/image-guided-radiation-therapy-for-post-operative-gynaecologic-cancer-patient-set-up-verification-with-and-without-implanted-fiducial-markers
#1
Donna H Murrell, Andrew Warner, Quinn Benwell, Wendy Wells, Danielle Scott, Vikram Velker, George Hajdok, David P D'Souza
BACKGROUND: Intensity modulated radiotherapy (IMRT) is increasingly being used to treat gynaecological malignancies in the postoperative setting. The purpose of this study was to evaluate the use of image-guided radiotherapy (IGRT) using cone-beam computed tomography (CBCT) with fiducial markers for daily localization. MATERIAL AND METHODS: A single institution study was performed of consecutive cervical or endometrial cancer patients receiving adjuvant external beam radiotherapy (n = 15)...
May 18, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29774030/changes-in-the-tcr%C3%AE-repertoire-and-tumor-immune-signature-from-a-cutaneous-melanoma-patient-immunized-with-the-csf-470-vaccine-a-case-report
#2
Mariana Aris, Alicia Inés Bravo, María Betina Pampena, Paula Alejandra Blanco, Ibel Carri, Daniel Koile, Patricio Yankilevich, Estrella Mariel Levy, María Marcela Barrio, José Mordoh
The allogeneic therapeutic vaccine CSF-470 has demonstrated a significant benefit over medium-dose IFNα2b in the distant metastasis-free survival for stages IIB-IIC-III cutaneous melanoma patients in a randomized phase II/III clinical trial (CASVAC-0401, NCT01729663). At the end of the 2-year CSF-470 immunization protocol, patient #006 developed several lung and one subcutaneous melanoma metastases; this later was excised. In this report, we analyzed the changes throughout vaccination of immune populations in blood and in the tumor tissue, with special focus on the T-cell repertoire...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29772227/evolutionary-shift-towards-lateral-line-dependent-prey-capture-behavior-in-the-blind-mexican-cavefish
#3
Evan Lloyd, Courtney Olive, Bethany A Stahl, James B Jaggard, Paloma Amaral, Erik R Duboue, Alex C Keene
Feeding strategies are dependent on multi-modal sensory processing, that integrates visual, chemosensory, and mechanoreceptive cues. In many fish species, local environments and food availability dramatically influence the evolution of sensory and morphological traits that underlie feeding. The Mexican cavefish, Astyanax mexicanus, have developed robust changes in sensory-dependent behaviors, but the impact on prey detection and feeding behavior is not known. In the absence of eyes, cavefish have evolved enhanced sensitivity of the lateral line, comprised of mechanosensory organs that sense water flow and detect prey...
May 14, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29771287/term-or-preterm-cesarean-section-delivery-does-not-lead-to-long-term-detrimental-consequences-in-mice
#4
Morgane Chiesa, Damien Guimond, Roman Tyzio, Alexandre Pons-Bennaceur, Natalia Lozovaya, Nail Burnashev, Diana C Ferrari, Yehezkel Ben-Ari
Epidemiological studies have provided contradictory data on the deleterious sequels of cesarean section (C-section) delivery and their links with developmental brain disorders such as Autism Spectrum Disorders. To gain better insight on these issues, we have now compared physiological, morphological, and behavioral parameters in vaginal, term, and preterm C-section delivered mice. We report that C-section delivery does not lead to long-term behavioral alterations though preterm C-section delivery modifies communicative behaviors in pups...
May 16, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29765107/space-wave-routing-via-surface-waves-using-a-metasurface-system
#5
Karim Achouri, Christophe Caloz
We introduce the concept of a metasurface system able to route space waves via surface waves. This concept may be used to laterally shift or modulate the beam width of scattered waves. The system is synthesized based on a momentum transfer approach using phase-gradient metasurfaces. The concept is experimentally verified in an "electromagnetic periscope". Additionally, we propose two other potential applications namely a beam expander and a multi-wave refractor.
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29760217/temporal-manipulation-of-mitochondrial-function-by-virulent-francisella-tularensis-to-limit-inflammation-and-control-cell-death
#6
Forrest Jessop, Benjamin Schwarz, Emily Heitmann, Robert Buntyn, Tara Wehrly, Catharine M Bosio
Francisella tularensis ssp tularensis (Ftt) is a highly pathogenic intracellular bacterium that suppresses host inflammation by impairing the metabolic shift from oxidative phosphorylation to glycolysis. Decreased mitochondrial metabolism is central to initiating a metabolic shift to glycolysis and regulating inflammation, but Ftt manipulation of host mitochondrial function has not been explored. We demonstrate using extracellular flux analysis that Ftt infection initially improves host macrophage mitochondrial bioenergetics in a capsule dependent manner...
May 14, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29758863/particle-size-differentiation-explains-flow-regulation-controls-on-sediment-sorting-in-the-water-level-fluctuation-zone-of-the-three-gorges-reservoir-china
#7
Qiang Tang, Adrian L Collins, Anbang Wen, Xiubin He, Yuhai Bao, Dongchun Yan, Yi Long, Yusheng Zhang
The Three Gorges Dam has significantly interrupted fluvial continuity and modified the mass transfer regime along river continuums. Flow regulation following regular dam operations drives dramatic hydrological regime shifts, which facilitates sediment dispersal in the water-level fluctuation zone over episodic inundation periods. How flow regulation modulates sediment redistribution, however, remains unclear. In this study, we depict absolute particle size composition of suspended sediment and sink sediment in the water-level fluctuation zone, and these are interpreted in the context of flow regulation controls on sediment sorting...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29756799/it-gets-better-with-time-enhancement-of-age-related-positivity-effect-in-the-six-months-following-a-highly-negative-public-event
#8
Jaclyn H Ford, Haley D DiBiase, Ehri Ryu, Elizabeth A Kensinger
Age is associated with shifts toward more positive memory retrieval. The current study examined these shifts following a negative public event. Participants completed two surveys examining emotional responses to the 2013 Boston Marathon bombings, one immediately following the attack and another 6 months later. Age was associated with different effects of time on how individuals reflected on this event. Time was associated with an increased focus on negative components in young adults but a decreased focus in older adults...
May 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29755898/an-unusual-presentation-of-kikuchi-fujimoto-disease-with-recurrent-subdural-effusion
#9
Sara Shahid, Syed H Alam, Indira Hadley
A 24-year-old man complained of a right temporal headache for four weeks. The patient denied any trauma or previous anticoagulation use. He also reported tender right facial swelling. His physical exam was unrevealing except for right cranial nerve (CN) VI palsy, right parotid enlargement, and cervical adenopathy. Laboratory findings were significant for mild leukopenia at 3300 cells/uL. The computed tomography (CT) scan obtained showed a chronic left subdural effusion with a 4 mm midline shift and confirmed right parotid enlargement and cervical lymphadenopathy...
March 10, 2018: Curēus
https://www.readbyqxmd.com/read/29752957/early-human-motor-development-from-variation-to-the-ability-to-vary-and-adapt
#10
REVIEW
Mijna Hadders-Algra
This review summarizes early human motor development. From early fetal age motor behavior is based on spontaneous neural activity: activity of networks in the brainstem and spinal cord that is modulated by supraspinal activity. The supraspinal activity, first primarily brought about by the cortical subplate, later by the cortical plate, induces movement variation. Initially, movement variation especially serves exploration; its associated afferent information is primarily used to sculpt the developing nervous system, and less to adapt motor behavior...
May 9, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29748379/sod1-a4v-aggregation-alters-ubiquitin-homeostasis-in-a-cell-model-of-als
#11
Natalie E Farrawell, Isabella Lambert-Smith, Kristen Mitchell, Jessie McKenna, Luke McAlary, Prajwal Ciryam, Kara L Vine, Darren N Saunders, Justin J Yerbury
A hallmark of amyotrophic lateral sclerosis (ALS) pathology is the accumulation of ubiquitinated protein inclusions within motor neurons. Recent studies suggest the sequestration of ubiquitin (Ub) into inclusions reduces the availability of free Ub, which is essential for cellular function and survival. However, the dynamics of the Ub landscape in ALS have not yet been described. Here we show that Ub homeostasis is altered in a SOD1 cell model of ALS. Monitoring the distribution of Ub in SOD1-expressing cells, we show that Ub is present at the earliest stages of SOD1 aggregation and cells containing mutant SOD1 aggregates have greater ubiquitin-proteasome system (UPS) dysfunction...
May 10, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29748034/ampk-induced-memory-improvements-in-the-diabetic-population-a-case-study
#12
Alicia Halikas, Kelly J Gibas
Diabetics in mid-life carry a 1.5 times higher risk of developing Alzheimer's disease than those diagnosed with diabetes (T2D) later in life [1]. Recent research points to accelerated cognitive decline within a range of 20%-50% for middle-aged diabetics as compared to non-diabetic populations [2,3]. Metabolic syndrome (MetS), a type 2 diabetes (T2D) precursor, is also linked to MCI and AD pathologies via hypo-metabolic brain circuitry that inhibits glucose metabolism and attenuates cognitive function [4]. Dysregulation of intracellular and extracellular signaling as mediated by the mTOR and AMPK pathways is the result...
April 27, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29743572/78-000-year-old-record-of-middle-and-later-stone-age-innovation-in-an-east-african-tropical-forest
#13
Ceri Shipton, Patrick Roberts, Will Archer, Simon J Armitage, Caesar Bita, James Blinkhorn, Colin Courtney-Mustaphi, Alison Crowther, Richard Curtis, Francesco d' Errico, Katerina Douka, Patrick Faulkner, Huw S Groucutt, Richard Helm, Andy I R Herries, Severinus Jembe, Nikos Kourampas, Julia Lee-Thorp, Rob Marchant, Julio Mercader, Africa Pitarch Marti, Mary E Prendergast, Ben Rowson, Amini Tengeza, Ruth Tibesasa, Tom S White, Michael D Petraglia, Nicole Boivin
The Middle to Later Stone Age transition in Africa has been debated as a significant shift in human technological, cultural, and cognitive evolution. However, the majority of research on this transition is currently focused on southern Africa due to a lack of long-term, stratified sites across much of the African continent. Here, we report a 78,000-year-long archeological record from Panga ya Saidi, a cave in the humid coastal forest of Kenya. Following a shift in toolkits ~67,000 years ago, novel symbolic and technological behaviors assemble in a non-unilinear manner...
May 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29743318/shift-work-night-work-and-sleep-disorders-among-pastry-cookers-and-shopkeepers-in-france-a-cross-sectional-survey
#14
Emilie Pepin, Pascal Gillet, Fabien Sauvet, Danielle Gomez-Merino, Isabelle Thaon, Mounir Chennaoui, Damien Leger
OBJECTIVE: Most research on night and shift work focuses on employee health in large companies, primarily in the healthcare and transportation sectors. However, many night workers work on their own or in small businesses related to services or food. This survey focuses on sleep habits and disorders concerning night work in pastry production and sales. METHODS: An epidemiological telephone cross-sectional survey of night shift workers and their sleep habits was proposed to all employers and employees in the French pastry industry via their insurance health prevention company...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29742199/diagnostic-and-therapeutic-strategies-in-cryptococcosis-impact-on-outcome
#15
Timothée Boyer Chammard, Elvis Temfack, Olivier Lortholary, Alexandre Alanio
Cryptococcosis diagnosis has been recently improved by the use of rapid cryptococcal antigen testing with lateral flow assays, which have proved sensitive and specific. Using "test and treat" screening strategies for cryptococcal disease with these tests has been showed effective in reducing cryptococcal meningitis (CM) in HIV-infected patients. Recommended induction, consolidation, and maintenance therapeutic strategy for CM is widely unavailable and/or expensive in low and middle-income settings...
2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29740963/long-term-health-implications-of-students-friendship-formation-during-the-transition-to-university
#16
Patrick Klaiber, Ashley V Whillans, Frances S Chen
BACKGROUND: The transition to university is a major life change wherein young adults' primary support system shifts from the family to peers. Can change in social integration (operationalised as number of friends) during the first term at university contribute to students' health years later, and if so, how? METHODS: The friendship formation of 67 students at a large Canadian university was assessed during their first term. These data were used to predict self-reported health and health behaviors (physical exercise, diet, tobacco, alcohol and marijuana consumption) at a follow-up assessment that occurred near the end of their time at university (2 or 3 years later)...
May 9, 2018: Applied Psychology. Health and Well-being
https://www.readbyqxmd.com/read/29738595/corneal-inlays-for-presbyopia-explanted-due-to-corneal-haze
#17
Hon Shing Ong, Anita S Chan, Christine W Yau, Jodhbir S Mehta
PURPOSE: To present 3 patients who required explantation of KAMRA inlays (AcuFocus, Inc., Irvine, CA) due to visual symptoms caused by postoperative corneal haze. METHODS: Case series. RESULTS: All patients had good near and distance vision immediately following implantation. They developed visual symptoms 3 to 6 years later. All patients reported a decline in distance vision. Two patients had hyperopic shift with flattening of the central cornea...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29737315/applicability-of-transoral-endoscopic-parathyroidectomy-through-vestibular-route-for-primary-sporadic-hyperparathyroidism-a-south-indian-experience
#18
P R K Bhargav, M Sabaretnam, V Amar, N Vimala Devi
Introduction: Primary hyperparathyroidism is one of the most common endocrine disorders requiring surgical parathyroidectomy for its definitive treatment. Surgical exploration is traditionally performed through conventional open neck approach. A wide range of minimal access and minimally invasive endoscopic techniques (gas less and with gas) have been attempted in the past two decades. In this context, we evaluated the feasibility and safety of an innovative transoral endoscopic parathyroidectomy (EP) technique, which represents a paradigm shift in transluminal endocrine surgery...
May 4, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29736816/pre-exposure-prophylaxis-for-hiv-infection-in-the-older-patient-what-can-be-recommended
#19
Iacopo Franconi, Giovanni Guaraldi
Over the past 15 years, a significant increase in new HIV/AIDS diagnoses has been observed in the elderly population. This new epidemiological shift has been attributed to a longer sex life, lifestyle and changes in sexual behavior, poor sexual health education, and misconceptions about the absence of sexually transmitted disease in later life. Although many biomedical and behavioral interventions have proven useful to prevent sexually transmitted infections and HIV, pre-exposure prophylaxis (PrEP) has been shown to be the most successful biomedical intervention to prevent HIV in high-risk individuals...
May 8, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29736301/surrogate-potency-assays-comparison-of-binding-profiles-complements-dose-response-curves-for-unambiguous-assessment-of-relative-potencies
#20
Robert Karlsson, Veronica Fridh, Åsa Frostell
Surface plasmon resonance (SPR) systems are widely used for detailed characterization of antibody activities including antigen and Fc-receptor binding. During the later stages of development, where the focus is to ensure that established critical quality attributes (CQAs) are maintained during cell culture, purification and formulation processes, analysis is simplified, and relative potencies are often determined. Here, simulation of binding data revealed that relative potency values, determined via parallel line analysis (PLA) and half maximal effective concentration (EC50) analysis accurately reflect changes in active concentration only if binding kinetics remain unchanged...
April 2018: Journal of Pharmaceutical Analysis
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