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Multiple sclerosis and nutrition

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https://www.readbyqxmd.com/read/29595826/pediatric-multiple-sclerosis-current-perspectives-on-health-behaviors
#1
REVIEW
Elizabeth Morghen Sikes, Robert W Motl, Jayne M Ness
Purpose: Pediatric-onset multiple sclerosis (POMS) accounts for ~5% of all multiple sclerosis cases, and has a prevalence of ~10,000 children in the USA. POMS is associated with a higher relapse rate, and results in irreversible disability on average 10 years earlier than adult-onset multiple sclerosis. Other manifestations of POMS include mental and physical fatigue, cognitive impairment, and depression. We believe that the health behaviors of physical activity, diet, and sleep may have potential benefits in POMS, and present a scoping review of the existing literature...
2018: Pediatric Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29565171/-effects-of-nutritional-status-on-the-multiple-sclerosis-disease-systematic-review
#2
Irene Ródenas Esteve, Carmina Wanden-Berghe, Javier Sanz-Valero
OBJECTIVE: To review the available scientific literature about the effects of nutritional status on the multiple sclerosis disease. METHODS: A systematic review of the scientific literature in the Medline (PubMed), Scopus, Cochrane Library and Web of Science databases through November 2016. Search equation: ("Multiple Sclerosis"[Mesh] OR "Multiple Sclerosis"[Title/Abstract] OR "Disseminated Sclerosis"[Title/Abstract] OR "Multiple Sclerosis Acute Fulminating"[Title/Abstract]) AND ("Nutritional Status"[Mesh] OR "Nutritional Status"[Title/Abstract] OR "Nutrition Status"[Title/Abstract])...
January 19, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29549521/the-evidence-for-dietary-interventions-and-nutritional-supplements-as-treatment-options-in-multiple-sclerosis-a-review
#3
REVIEW
Leah J Mische, Ellen M Mowry
PURPOSE OF REVIEW: This review aims to critically evaluate published studies examining diets and nutritional supplements (excepting vitamin D) for the impact on prevention and prognosis of multiple sclerosis (MS). RECENT FINDINGS: There is a negative relationship between the Mediterranean diet and vascular disease, and vascular co-morbidities are associated with a worse MS prognosis. Low-fat, fish-based diets, sodium-restricted diets, calorie restriction, the paleo diet, and gluten-free diets have been examined, mostly in observational studies; results are inconclusive...
March 17, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29516151/-nutrition-microbiome-and-multiple-sclerosis-current-knowledge-from-basic-research-and-clinical-practice
#4
A Haghikia, R A Linker
Epidemiological data indicate a disproportional increase in the incidence of multiple sclerosis (MS) over the last decades, particularly in industrialized countries. Although this increase is also associated with altered diagnostic criteria and improved sensitivity of imaging procedures, current data suggest that particularly alterations in our way of life play an important role. In recent years the importance of the gut and intestinal microbiome for some neurological diseases and in particular for MS was recognized...
March 7, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29510324/a-survey-of-dietary-characteristics-in-a-large-population-of-people-with-multiple-sclerosis
#5
Kathryn C Fitzgerald, Tuula Tyry, Amber Salter, Stacey S Cofield, Gary Cutter, Robert J Fox, Ruth Ann Marrie
INTRODUCTION: Dietary approaches to management of MS has been proposed for several decades, yet very little is known concerning dietary composition or adherence to specialized diets in people with multiple sclerosis (MS). METHODS: We conducted a survey of participants in the North American Research Committee on MS (NARCOMS) registry assessing diet composition and the prevalence of 19 different diets. We characterized prevalence of different diets and compared diet composition with estimated intakes from the National Health and Nutrition Examination Survey (NHANES) survey respondents and across demographics and MS clinical characteristics...
February 27, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29403649/a-protocol-for-a-randomised-double-blind-placebo-controlled-feasibility-study-to-determine-whether-the-daily-consumption-of-flavonoid-rich-pure-cocoa-has-the-potential-to-reduce-fatigue-in-people-with-relapsing-and-remitting-multiple-sclerosis-rrms
#6
S Coe, J Collett, H Izadi, D T Wade, M Clegg, J M Harrison, E Buckingham, A Cavey, G C DeLuca, J Palace, H Dawes
Background: Dietary interventions including consumption of flavonoids, plant compounds found in certain foods, may have the ability to improve fatigue. However, to date, no well-designed intervention studies assessing the role of flavonoid consumption for fatigue management in people with MS (pwMS) have been performed. The hypothesis is that the consumption of a flavonoid-rich pure cocoa beverage will reduce fatigue in pwMS. The aim of this study is to determine the feasibility and potential outcome of running a trial to evaluate this hypothesis...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29384828/evaluation-of-vitamin-b12-deficiency-and-associated-factors-in-patients-with-systemic-sclerosis
#7
Diler Tas Kilic, Ali Akdogan, Levent Kilic, Alper Sari, Abdulsamet Erden, Berkan Armagan, Muhammed Kilickaya, Umut Kalyoncu, Turan Turhan, Sedat Kiraz, Selma Karaahmetoglu
BACKGROUND/OBJECTIVE: In patients with systemic sclerosis (SSc) gastrointestinal (GI) involvement, nutritional status and medications may lead to cobalamin (Vit B12) deficiency. We aimed to determine the frequency and the potential causes of Vit B12 deficiency in SSc patients. METHODS: We conducted a cross-sectional analysis of 62 SSc patients in a single center in 1 year period. Medical history and physical examination of patients were reevaluated. Data about organ involvements were obtained from hospital file records...
January 30, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29341125/gut-microbiota-and-probiotics-novel-immune-system-modulators-in-myasthenia-gravis
#8
REVIEW
Elena Rinaldi, Alessandra Consonni, Elena Guidesi, Marina Elli, Renato Mantegazza, Fulvio Baggi
Gut microorganisms (microbiota) live in symbiosis with the host and influence human nutrition, metabolism, physiology, and immune development and function. The microbiota prevents pathogen infection to the host, and in turn the host provides a niche for survival. The alteration of gut bacteria composition (dysbiosis) could contribute to the development of immune-mediated diseases by influencing the immune system activation and driving the pro- and anti-inflammatory responses in order to promote or counteract immune reactions...
January 17, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29331869/dietary-naringenin-supplementation-attenuates-experimental-autoimmune-encephalomyelitis-by-modulating-autoimmune-inflammatory-responses-in-mice
#9
Junpeng Wang, Ying Qi, Xinli Niu, Hua Tang, Simin Nikbin Meydani, Dayong Wu
Autoimmune disease is highly prevalent in humans. Since conventional therapies have limited efficacy and often come with significant side effects, nutrition may provide an alternative and complementary approach to improving autoimmune disorders. Naringenin, a flavonoid found in citrus fruits, has been shown to have anti-inflammatory and antioxidant properties. Using the experimental autoimmune encephalomyelitis (EAE), a rodent model of human multiple sclerosis, we determined the effect of dietary naringenin (0...
April 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29274834/espen-guideline-clinical-nutrition-in-neurology
#10
Rosa Burgos, Irene Bretón, Emanuele Cereda, Jean Claude Desport, Rainer Dziewas, Laurence Genton, Filomena Gomes, Pierre Jésus, Andreas Leischker, Maurizio Muscaritoli, Kalliopi-Anna Poulia, Jean Charles Preiser, Marjolein Van der Marck, Rainer Wirth, Pierre Singer, Stephan C Bischoff
Neurological diseases are frequently associated with swallowing disorders and malnutrition. Moreover, patients with neurological diseases are at increased risk of micronutrient deficiency and dehydration. On the other hand, nutritional factors may be involved in the pathogenesis of neurological diseases. Multiple causes for the development of malnutrition in patients with neurological diseases are known including oropharyngeal dysphagia, impaired consciousness, perception deficits, cognitive dysfunction, and increased needs...
February 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29247071/evaluation-of-idiopathic-transverse-myelitis-revealing-specific-myelopathy-diagnoses
#11
Nicholas L Zalewski, Eoin P Flanagan, B Mark Keegan
OBJECTIVE: To evaluate specific myelopathy diagnoses made in patients with suspected idiopathic transverse myelitis (ITM). METHODS: A total of 226 patients 18 years and older were referred to Mayo Clinic Neurology for suspected ITM from December 1, 2010, to December 31, 2015. Electronic medical records were reviewed for detailed clinical presentation and course, laboratory and electrophysiologic investigations, and neuroimaging to determine the etiology. Current diagnostic criteria for ITM and alternative myelopathy diagnoses were applied...
January 9, 2018: Neurology
https://www.readbyqxmd.com/read/29243005/efficacy-and-safety-outcomes-in-vitamin-d-supplement-users-in-the-fingolimod-phase-3-trials
#12
Kira Hongell, Diego G Silva, Shannon Ritter, Daniela Piani Meier, Merja Soilu-Hänninen
BACKGROUND: Low serum levels of 25-hydroxyvitamin D have been associated with worse outcomes in multiple sclerosis (MS) patients treated with interferon-beta. Association of vitamin D nutrition on the outcomes of other MS therapies has been studied less. OBJECTIVE: Whether patients in the phase 3 fingolimod trials using vitamin D supplements have better clinical, MRI and safety outcomes than non-users. MATERIALS AND METHODS: Pooled data from phase 3 FREEDOMS trials was analyzed post hoc...
February 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29157400/advanced-symptom-management-in-multiple-sclerosis
#13
REVIEW
Elizabeth Crabtree-Hartman
Meaningful symptom management can have a profound impact on quality of life. It can challenge time parameters during clinic, and therefore thought should be given to strategies that can improve efficiency and thereby make the undertaking more tenable. For any given symptom, the building blocks of care, such as vitamin D status, exercise/physical therapy, nutrition, and stress management, and ensuring disease-modifying therapy coverage, should be maximized. For each symptom, there are pharmacologic and nonpharmacologic interventions...
February 2018: Neurologic Clinics
https://www.readbyqxmd.com/read/29083070/breastfeeding-and-autoimmunity-programing-health-from-the-beginning
#14
REVIEW
Vânia Vieira Borba, Kassem Sharif, Yehuda Shoenfeld
Breast milk is not only a completely adapted nutrition source for the newborn but also an impressive array of immune-active molecules that afford protection against infections and shape mucosal immune responses. Decisive imprinting events might be modulated during the first months of life with potential health long-term effects, enhancing the importance of breastfeeding as a major influence on the immune system correct development and modifying disease susceptibility. The aim of this review was to clarify the link between breastfeeding and autoimmune diseases, inquiring the related mechanisms, based on data available in the literature...
January 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29081604/what-is-hyper-in-the-als-hypermetabolism
#15
REVIEW
Alberto Ferri, Roberto Coccurello
The progressive and fatal loss of upper (brain) and lower (spinal cord) motor neurons and muscle denervation concisely condenses the clinical picture of amyotrophic lateral sclerosis (ALS). Despite the multiple mechanisms believed to underlie the selective loss of motor neurons, ALS aetiology remains elusive and obscure. Likewise, there is also a cluster of alterations in ALS patients in which muscle wasting, body weight loss, eating dysfunction, and abnormal energy dissipation coexist. Defective energy metabolism characterizes the ALS progression, and such paradox of energy balance stands as a challenge for the understanding of ALS pathogenesis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28993475/diet-and-disease-modification-in-multiple-sclerosis-a-nutritional-epidemiology-perspective
#16
EDITORIAL
Kathryn Fitzgerald
No abstract text is available yet for this article.
January 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28979790/differential-diagnosis-of-multiple-sclerosis-in-latin-america
#17
REVIEW
Y D Fragoso, F G Elso, A Carrá
Improvement of multiple sclerosis (MS) diagnoses leads to earlier and correct disease management. The differential diagnostic workup for MS comprises a large variety of medical conditions. There are general guidelines and criteria for diagnosing MS worldwide, but awareness of regional differences needs to be kept in mind. Latin American patients who are screened for MS diagnoses may require an approach that is not exactly the same as that used for patients in North America, western Europe or Asia. In the present review, the conditions that are important for the differential diagnoses of MS in Latin America are reviewed...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28947637/vitamin-d-supplementation
#18
EDITORIAL
Ruth Dobson, Hannah R Cock, Peter Brex, Gavin Giovannoni
Vitamin D testing and supplementation is of great interest to neurologists and their patients. Recommended nutritional intakes of vitamin D in the UK remain focused on bone health, despite increasing evidence for a role outside this area. Here we discuss how neurologists might approach vitamin D testing and supplementation, focusing on two conditions associated with vitamin D deficiency that have an increased risk of downstream complications resulting from these: multiple sclerosis and epilepsy. We set out a rationale for testing serum 25-hydroxyvitamin D concentrations and discuss our personal practice in terms of supplementation, with evidence where available...
February 2018: Practical Neurology
https://www.readbyqxmd.com/read/28708108/gut-cns-axis-as-possibility-to-modulate-inflammatory-disease-activity-implications-for-multiple-sclerosis
#19
REVIEW
Ann-Katrin Fleck, Detlef Schuppan, Heinz Wiendl, Luisa Klotz
In the last decade the role of environmental factors as modulators of disease activity and progression has received increasing attention. In contrast to classical environmental modulators such as exposure to sun-light or fine dust pollution, nutrition is an ideal tool for a personalized human intervention. Various studies demonstrate a key role of dietary factors in autoimmune diseases including Inflammatory Bowel Disease (IBD), rheumatoid arthritis or inflammatory central nervous system (CNS) diseases such as Multiple Sclerosis (MS)...
July 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28701385/biotin-from-nutrition-to-therapeutics
#20
REVIEW
Donald M Mock
Although frank symptomatic biotin deficiency is rare, some evidence suggests that marginal biotin deficiency occurs spontaneously in a substantial proportion of women during normal human pregnancy and might confer an increased risk of birth defects. Herein I review 1 ) advances in assessing biotin status, including the relation between acylcarnitine excretion and biotin status; 2 ) recent studies of biotin status in pregnancy; 3 ) advances in understanding the role of biotin in gene expression and the potential roles of biotinylated proteins that are neither histones nor carboxylases; and 4 ) novel large-dose biotin supplementation as therapy for multiple sclerosis...
August 2017: Journal of Nutrition
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