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Dermatophyte

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https://www.readbyqxmd.com/read/28540871/clinico-mycological-study-of-dermatophytic-infections-and-their-sensitivity-to-antifungal-drugs-in-a-tertiary-care-center
#1
Soniya Mahajan, Ragini Tilak, Satyendra K Kaushal, Rabindra N Mishra, Shyam S Pandey
BACKGROUND: Worldwide, dermatophytic infections are running a chronic course either due to ineffective treatment or emerging drug resistance. In the past three decades, there has been an increase in incidence and non-responsiveness to conventional antifungals, which suggests that there is a need of antifungal sensitivity testing. AIMS: This study was aimed at identifying clinico-mycological pattern of dermatophytic infections in patients attending thedermatology outpatient department of a tertiary care hospital, and to obtain the sensitivity pattern of isolates against six commonly used oral antifungals (fluconazole, terbinafine, itraconazole, ketoconazole, griseofulvin and voriconazole)...
May 22, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28525623/the-survey-of-tinea-capitis-and-scalp-dermatophyte-carriage-in-nursing-home-residents
#2
Chien-Yio Lin, Hsiu-Jung Lo, Ming-Gene Tu, Yu-Ming Ju, Yun-Chen Fan, Chih-Chao Lin, Ya-Ting Chiang, Yun-Liang Yang, Kai-Ting Chen, Pei-Lun Sun
Tinea capitis is a contagious dermatophyte infection of scalp and associated hairs. On the other hand, asymptomatic carriage is a status of positive dermatophyte scalp culture, but without signs or symptoms of tinea capitis, and no evidence of hair shaft invasion confirmed by direct microscopy. Tinea capitis and asymptomatic carriage mostly occur in children, but adult females are becoming another population in recent decades. In this study, we focused on the prevalence and related fungi of tinea capitis and asymptomatic carriage in elderly by the shampoo brush method, as well as the source of transmission, in 10 nursing home residents...
May 18, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28524381/antifungal-activity-of-gallic-acid-in-vitro-and-in-vivo
#3
Zhi-Jian Li, Meng Liu, Gulina Dawuti, Qin Dou, Yu Ma, Heng-Ge Liu, Silafu Aibai
Gallic acid (GA) is a polyphenol natural compound found in many medicinal plant species, including pomegranate rind (Punica granatum L.), and has been shown to have antiinflammatory and antibacterial properties. Pomegranate rind is used to treat bacterial and fungal pathogens in Uyghur and other systems of traditional medicine, but, surprisingly, the effects of GA on antifungal activity have not yet been reported. In this study, we aimed to investigate the inhibitory effects of GA on fungal strains both in vitro and in vivo...
May 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28521541/evaluation-of-the-efficacy-and-safety-of-tavaborole-topical-solution-5-in-the-treatment-of-onychomycosis-of-the-toenail-in-adults-a-pooled-analysis-of-an-8-week-poststudy-follow-up-from-two-randomized-phase-3-studies
#4
Aditya K Gupta, Steve Hall, Lee T Zane, Shari R Lipner, Phoebe Rich
PURPOSE: The role of topical antifungal agents in the long-term management of toenail onychomycosis is not well established. The current study evaluated durability of clinical benefit of tavaborole topical solution, 5%, for the treatment of toenail onychomycosis. METHODS: We conducted a pooled analysis of 8-week, poststudy follow-up (PSFU) data from two phase 3, randomized controlled trials in a subset of patients who experienced complete or almost clear nail at the end of treatment (week 52); 48 weeks of treatment with once-daily tavaborole compared with placebo in adults with distal subungual onychomycosis was evaluated at week 60...
May 18, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28513812/common-dermatophytes-and-in-vitro-anti-fungal-susceptibility-testing-in-patients-attending-the-dermatological-clinic-at-the-hospital-for-tropical-medicine-bangkok
#5
Watcharamat Muangkaew, Thanwa Wongsuk, Natthanej Luplertlop
Dermatophytes comprising the genera Trichophyton, Microsporum, and Epidermophyton are important causes of superficial mycoses. The number of infected patients and the distribution of species of these organisms in our hospital were unknown. We therefore aimed to investigate the clinical pattern of dermatophyte infections and to identify the species of these dermatophytes at the Dermatological Clinic of the Hospital for Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok in a 1-year period...
May 17, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28508389/usefulness-of-techniques-based-on-real-time-pcr-for-the-identification-of-onychomycosis-causing-species
#6
Anissa Z Hafirassou, Clara Valero, Nadia Gassem, Ilhem Mihoubi, Maria J Buitrago
Onychomycosis (OM) is a nail infection caused mainly by dermatophyte species but other species of yeast and moulds are frequently involved as well. Classical diagnosis has limitations thus empirical treatment is common. The usefulness of different real time PCR (RT-PCR) assays for identifying species causing OM was assessed in samples from seventy patients and fifteen controls. Conventional methods and four different RT-PCR assays were used: a panfungal, a pandermatophyte and two specific assays for detecting Candida spp...
May 16, 2017: Mycoses
https://www.readbyqxmd.com/read/28504456/performance-of-mycology-and-histopathology-tests-for-the-diagnosis-of-toenail-onychomycosis-due-to-filamentous-fungi-dermatophyte-and-non-dermatophyte-moulds
#7
Fernanda G Lavorato, Dávson A Guimarães, Mario G Premazzi, Juan M Piñeiro-Maceira, Andréa R Bernardes-Engemann, Rosane Orofino-Costa
Improvement of laboratory diagnosis of onychomychosis is important so that adequate treatment can be safely implemented. To evaluate and compare the performance of mycological and histopathological examinations in onychomycoses caused by dermatophyte and non-dermatophyte moulds. Patients with lateral/distal subungual onychomycosis in at least one hallux were enrolled in the protocol and assessed via mycological and histopathological tests. The isolation of filamentous fungi was considered the gold standard...
May 15, 2017: Mycoses
https://www.readbyqxmd.com/read/28501468/-tinea-capitis-main-mycosis-child-epidemiological-study-on-10years
#8
A Kallel, A Hdider, N Fakhfakh, S Belhadj, N Belhadj-Salah, N Bada, A Chouchen, S Ennigrou, K Kallel
Despite the changes in their epidemiology, and the improving level of hygiene of the population, tinea capitis is still considered a public health problem in our country, and is the most common type of dermatophytosis in our country. The aim of our study was to evaluate the epidemiological, clinical and mycological features of tinea capitis in children encountered in the Tunis region. A retrospective study concerned 1600 children aged 6 months to 15 years suspected to have tinea capitis was conducted in Parasitology-Mycology laboratory, Rabta hospital, over a 10-years period (2005-2014)...
May 10, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28480990/production-of-trichophyton-rubrum-microspores-in-large-quantities-and-its-application-to-evaluate-amorolfine-azole-compound-interactions-in-vitro
#9
Alexis Laurent, Michel Monod
Trichophyton rubrum is the most frequently isolated dermatophyte species in European countries. The lack or poor sporulation of T. rubrum has always been a major complication and a limiting factor when performing antifungal susceptibility testing. Therefore, we describe an in vitro method aiming to enhance sporulation of various T. rubrum isolates in order to perform antifungigrams. A combination of high CO2 tensions and incubation on PDA growth medium revealed to be optimal for sporulation of all tested T...
May 8, 2017: Mycoses
https://www.readbyqxmd.com/read/28477005/biosynthesis-of-zinc-oxide-nanoparticles-by-petals-extract-of-rosa-indica-l-its-formulation-as-nail-paint-and-evaluation-of-antifungal-activity-against-fungi-causing-onychomycosis
#10
Nikita Tiwari, Raksha Pandit, Swapnil Gaikwad, Aniket Gade, Mahendra Rai
Aim: The authors report the biological synthesis of zinc oxide nanoparticles (ZnO-NPs) from the petals extract of Rosa indica L. (rose). Its efficacy was evaluated against two dermatophytes: namely: Trichophyton mentagrophytes and Microsporum canis which cause onychomycosis. The activity of antibiotics against the tested dermatophytes was enhanced, when evaluated in combination with ZnO-NPs. Methods and results: The synthesised ZnO-NPs were preliminary detected by using ultraviolet UV visible spectroscopy, which showed specific absorbance...
March 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28459224/trichophyton-verrucosum-infection-in-livestock-in-the-chitral-district-of-pakistan
#11
Khalid Hameed, Farhana Riaz Ch, Muhammad Ali Nawaz, Syed Muhammad Saqlan Naqvi, Yvonne Gräser, Christiane Kupsch, Mario Pasquetti, Luca Rossi, Anna Rita Molinar Min, Paolo Tizzani, Elisa Chiavassa, Andrea Peano
INTRODUCTION: Trichophyton verrucosum belongs to the dermatophyte fungi, closely related organisms that cause skin infections in animals and humans. T. verrucosum infection has been reported in livestock and people in different countries from all continents. Human cases have been reported in different areas of Pakistan, but there is little information about the animal source of the fungus. METHODOLOGY: Dermatological specimens collected in the Chitral district of Pakistan for a study on mange in livestock were retrospectively analyzed for the presence of T...
April 30, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28442200/next-generation-sequencing-and-culture-based-techniques-offer-complementary-insights-into-fungi-and-prokaryotes-in-beach-sands
#12
Daniela Romão, Christopher Staley, Filipa Ferreira, Raquel Rodrigues, Raquel Sabino, Cristina Veríssimo, Ping Wang, Michael Sadowsky, João Brandão
A next-generation sequencing (NGS) approach, in conjunction with culture-based methods, was used to examine fungal and prokaryotic communities for the presence of potential pathogens in beach sands throughout Portugal. Culture-based fungal enumeration revealed low and variable concentrations of the species targeted (yeasts and dermatophytes), which were underrepresented in the community characterized by NGS targeting the ITS1 region. Conversely, NGS indicated that the potentially pathogenic species Purpureocillium liliacinum comprised nearly the entire fungal community...
April 23, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28425361/assessment-of-real-time-pcr-cycle-threshold-values-in-microsporum-canis-culture-positive-and-culture-negative-cats-in-an-animal-shelter-a-field-study
#13
Linda S Jacobson, Lauren McIntyre, Jenny Mykusz
Objectives Real-time PCR provides quantitative information, recorded as the cycle threshold (Ct) value, about the number of organisms detected in a diagnostic sample. The Ct value correlates with the number of copies of the target organism in an inversely proportional and exponential relationship. The aim of the study was to determine whether Ct values could be used to distinguish between culture-positive and culture-negative samples. Methods This was a retrospective analysis of Ct values from dermatophyte PCR results in cats with suspicious skin lesions or suspected exposure to dermatophytosis...
April 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28419352/dermatophytes-and-dermatophytosis-in-the-eastern-and-southern-parts-of-africa
#14
E I Nweze, I E Eke
Dermatophytosis is currently a disease of global importance and a public health burden. It is caused by dermatophytes, which attack and grow on dead animal keratin. Dermatophytes belong to three genera, namely, Epidermophyton, Microsporum, and Trichophyton. The predominant clinical forms and causative agents vary from one region of the world to another. Poor socioeconomic status, high population densities, and poor sanitary conditions are some of the factors responsible for the high prevalence of dermatophytosis in many developing countries, which include countries in southern and eastern Africa, the focus of this review...
April 17, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28416557/terbinafine-resistance-of-trichophyton-clinical-isolates-caused-by-specific-point-mutations-in-the-squalene-epoxidase-gene
#15
Tsuyoshi Yamada, Mari Maeda, Mohamed Mahdi Alshahni, Reiko Tanaka, Takashi Yaguchi, Olympia Bontems, Karine Salamin, Marina Fratti, Michel Monod
Terbinafine is one of the allylamine antifungal agents, whose target is squalene epoxidase (SQLE). This agent has been extensively used in the therapy of dermatophyte infections. The incidence of patients with tinea pedis or unguium tolerant to terbinafine treatment prompted us to screen terbinafine resistance of all Trichophyton clinical isolates from the laboratory of Centre Hospitalier Universitaire Vaudois collected over a three-year period, and to identify their mechanism of resistance. Among 2056 tested isolates, 17 (≈ 1%) showed reduced terbinafine susceptibility, all of which were found to harbor SQLE gene alleles with different single point mutations, leading to single amino acid substitutions at one of four positions (Leu(393), Phe(397), Phe(415) and His(440)) of the SQLE protein...
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28405548/clinicoepidemiological-and-mycological-study-of-tinea-capitis-in-the-pediatric-population-of-kashmir-valley-a-study-from-a-tertiary-care-centre
#16
Yasmeen J Bhat, Sumaya Zeerak, Farhat Kanth, Atiya Yaseen, Iffat Hassan, Rubina Hakak
BACKGROUND: Tinea capitis is a superficial fungal infection that predominantly affects the pediatric population. The etiological factors vary from region to region, and the exact incidence remains obscure. The clinicoepidemiological and mycological aspects of this dermatophytosis were studied in a tertiary care centre in Kashmir valley. AIM: To determine the clinicoepidemiological aspects and mycological findings of dermatophytes involved in tinea capitis cases in Kashmir valley...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28403528/superficial-black-onychomycosis-due-to-neoscytalidium-dimidiatum
#17
N Di Chiacchio, L F Noriega, N Gioia Di Chiacchio, J Ocampo-Garza
Onychomycosis is the most common onychopathy observed in adults and the elderly, and it is a frequent reason for medical visits.(1) Its prevalence ranges from 2.0-26.9%, depending on the population and geographic region.(1,2) Non-dermatophyte molds are responsible for 1.5-17.6% of onychomycosis cases, with higher prevalence in tropical and subtropical countries. This article is protected by copyright. All rights reserved.
April 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28399217/fungi-isolated-from-house-flies-diptera-muscidae-on-penned-cattle-in-south-texas
#18
Cherity A Ysquierdo, Pia U Olafson, Donald B Thomas
Musca domestica L. were collected from cattle diagnosed with bovine ringworm to evaluate the potential of the house fly to disseminate Trichophyton verrucosum E. Bodin, a fungal dermatophyte that is the causative agent for ringworm in cattle. Fungal isolates were cultured from 45 individual flies on supplemented Sabouraud dextrose agar, and isolates were identified using morphological and microscopic approaches. Each isolate was identified further by PCR amplification of the ribosomal DNA locus with fungal-specific primers and subsequent amplicon sequencing...
May 1, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28391957/dermatophytic-disease-with-deficit-in-card9-a-new-case-with-a-brain-impairment
#19
O Boudghene Stambouli, N Amrani, K Boudghéne Stambouli, F Bouali
INTRODUCTION: Dermatophytic disease individualized by Hadida and Schousboe in 1959 is a rare form of chronic dermatophyte infection; characterized by subcutaneous and visceral invasion and a therapeutic failure. We report a case of dermatophytic disease with brain abscess in an Algerian patient. OBSERVATIONS: The patient was 47-year-old, she was born parents first cousins. She had since the age of 10 years scaly scalp lesions that became secondarily papular and nodular...
April 5, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28391495/boric-acid-inhibition-of-trichophyton-rubrum-growth-and-conidia-formation
#20
Martin Schmidt
Trichophyton rubrum is a common human dermatophyte that is the causative agent of 80-93% of fungal infections of the skin and nails. While dermatophyte infections in healthy people are easily treatable with over-the-counter medications, such infections pose a higher risk for patients with compromised immune function and impaired regenerative potential. The efficacy of boric acid (BA) for the treatment of vaginal yeast infections prompted an investigation of the effect of BA on growth and morphology of T. rubrum...
April 8, 2017: Biological Trace Element Research
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