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Dermatophyte

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https://www.readbyqxmd.com/read/29774605/mixed-infections-are-a-critical-factor-in-the-treatment-of-superficial-mycoses
#1
A Gawaz, G Weisel
BACKGROUND: Superficial fungal infections of the skin, nails and hair are common with Trichophyton rubrum and Candida albicans being the main pathogens. Yet, in some patients, mycological cultures show growth of more than one fungal agent in the same anatomical region. OBJECTIVE: This study analyses prevalence, frequency and fungal agents found in superficial fungal mixed infections and discusses consequences for diagnostics and treatment. METHODS: Mycological data obtained between January 2006 to December 2015 from clinical specimens from a total cohort of 7733 patients with suspected fungal infections were retrospectively analysed...
May 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29773434/tinea-blepharo-ciliaris-in-a-13-year-old-girl-caused-by-trichophyton-benhamiae
#2
Fang-Ying Wang, Pei-Lun Sun
Tinea blepharo-ciliaris is a rare form of dermatophyte infection which involves eyelids and associated eyelashes. We report a 13-year-old girl with type I diabetes mellitus who had right eyelid swelling and eyelash loss for two weeks. The lesions were presented as erythematous patches with scales and tiny pustules on the right upper and lower eyelids with broken eyelashes. Two additional annular erythematous patches with scaly active borders were found on her right forearm and right thigh. Microscopic examination of broken eyelashes demonstrated many chains of arthroconidia and hyaline hyphae in an endothrix invasion pattern...
May 14, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29767317/successful-sequential-treatment-with-itraconazole-and-ala-pdt-for-cutaneous-granuloma-by-candida-albicans-a-case-report-and-literature-review
#3
Qing Cai, Lian-Juan Yang, Jia Chen, Hong Yang, Zhi-Qin Gao, Xiu-Li Wang
Photodynamic therapy (PDT) is a process that combines a photosensitizing drug and light and promotes phototoxic responses in target cells, mainly via oxidative damage. Antifungal photodynamic therapy has been successfully employed against Candida species, dermatophytes, and deep mycoses. We present a case of a cutaneous granuloma caused by C. albicans treated with 5-aminolevulinic acid (ALA)-PDT. A 64-year-old man presented with two plaques on his right hand and wrist for 2 years. The diagnosis was made based on histopathology, mycology, and molecular identification of paraffin-embedded tissues...
May 16, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29762871/fast-identification-of-dermatophytes-by-maldi-tof-ms-using-direct-transfer-of-fungal-cells-on-ground-steel-target-plates
#4
Keith C da Cunha, Arnaud Riat, Anne-Cecile Normand, Philipp P Bosshard, Margarete T G de Almeida, Renaud Piarroux, Jacques Schrenzel, Lionel Fontao
BACKGROUND: Dermatophytes cause human infections limited to keratinized tissues. We showed that the direct transfer method allows reliable identification of non-dermatophytes mould and yeast by MALDI-TOF/MS. OBJECTIVES: We aimed at assessing whether the direct transfer method can be used for dermatophytes and whether an own mass spectra library would be superior to the Bruker library. METHODS: We used the Bruker Biotyper to build a dermatophyte mass spectra library and assessed its performance by 1/ testing a panel of mass spectrum produced with strains genotypically identified and, 2/ comparing MALDI-TOF/MS identification to morphology-based methods...
May 15, 2018: Mycoses
https://www.readbyqxmd.com/read/29762721/clinical-evaluation-of-the-dermagenius%C3%A2-nail-real-time-pcr-assay-for-the-detection-of-dermatophytes-and-candida-albicans-in-nails
#5
Marie-Pierre Hayette, Laurence Seidel, Caroline Adjetey, Rajae Darfouf, Marie Wéry, Raphaël Boreux, Rosalie Sacheli, Pierrette Melin, Jorge Arrese
Onychomycosis represents one of the most frequent mycoses in the world. Causative agents are mainly dermatophytes, but yeasts and nondermatophyte moulds can also be involved. Conventional diagnostic methods include direct microscopy (or histology) and culturing. However, molecular methods are becoming increasingly popular in this field. The DermaGenius® (DG) Nail multiplex assay (PathoNostics, The Netherlands) is a new commercial real-time polymerase chain reaction (PCR) kit, which can detect Trichophyton rubrum, Trichophyton interdigitale and Candida albicans directly in nails...
May 11, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29760128/nitric-oxide-releasing-macromolecule-exhibits-broad-spectrum-anti-fungal-activity-and-utility-as-a-topical-treatment-for-superficial-fungal-infections
#6
Nathan Stasko, Kimberly McHale, Stanley J Hollenbach, Megan Martin, Ryan Doxey
Cutaneous and superficial fungal infections affecting the skin, nails, and hair of humans are caused primarily by dermatophytes of the genera Trichophyton, and Epidermophyton, or by yeasts of the genera Candida and Malassezia Onychomycosis is a common fungal infection of the nail frequently coexisting with tinea pedis, the most prevalent mycotic skin infection. Efficacy rates for current topical onychomycosis therapies are hampered by low drug penetration across the nail plate that is theoretically obviated with nitric oxide (NO)-based topical therapies...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29720523/conservation-of-mannan-synthesis-in-fungi-of-the-zygomycota-and-ascomycota-reveals-a-broad-diagnostic-target
#7
Amanda R Burnham-Marusich, Breeana Hubbard, Alexander J Kvam, Marcellene Gates-Hollingsworth, Heather R Green, Eric Soukup, Andrew H Limper, Thomas R Kozel
Ascomycetes and zygomycetes account for the majority of (i) fungi responsible for cutaneous, subcutaneous, and invasive human fungal infections, (ii) plant fungal pathogens, (iii) fungi that threaten global biodiversity, (iv) fungal agents of agricultural spoilage, and (v) fungi in water-damaged buildings. Rapid recognition of fungal infection (or contamination) enables early treatment (or remediation). A bioinformatics search found homologues of Saccharomyces cerevisiae Mnn9p present in members of the Zygomycota and Ascomycota phyla and absent in members of the Chytridiomycota and Basidiomycota...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29707676/mycological-aspects-of-onychomycosis-in-khuzestan-province-iran-a-shift-from-dermatophytes-towards-yeasts
#8
Mahnaz Fatahinia, Sima Jafarpour, Abdollah Rafiei, Simin Taghipour, Koichi Makimura, Ali Rezaei-Matehkolaei
Background and Purpose: Onychomycosis is fungal infection of the nails with an overall increasing incidence, worldwide. The epidemiological aspects of onychomycosis in Khuzestan, Iran, have not been established. In this study, we aimed to evaluate the clinical and mycological status of fungal nail infection in Khuzestan Province, Iran. Materials and Methods: The study population included 433 patients (143 males vs. 290 females). Nail samples underwent primary direct microscopy and culture...
December 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29707673/phytochemical-analysis-and-docking-study-of-compounds-present-in-a-polyherbal-preparation-used-in-the-treatment-of-dermatophytosis
#9
Nagesh Simhadri Vsdna, Muthuchamy Muniappan, Iyanar Kannan, Subramanyam Viswanathan
Background and Purpose: Soleshine is a polyherbal preparation established in the market for the treatment of cracks and tinea pedis, which is applied externally. This preparation is composed of the extracts of indigenous plants, namely Azadirachta indica, Lawsonia alba, and Shorea robusta , mixed with castor oil and sesame oil. In the present study, an attempt was made to identify the constituents of soleshine and identify some potential drug-like molecules that can inhibit important drug targets of the dermatophytes using molecular docking method...
December 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29695525/ultra-high-resolution-mass-spectrometry-of-closely-related-dermatophytes-with-different-clinical-predilections
#10
Karolina Dukik, Joanna Freeke, Azadeh Jamalian, Bert Gerrits van den Ende, Ping Yip, James L Stephenson, G Sybren de Hoog, J Benjamin Stielow
In the present study, an innovative top-down liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the identification of clinically relevant fungi is tested using a model set of dermatophyte strains. The methodology characterizes intact proteins derived from Trichophyton species which are used as parameters of differentiation. To test its resolving power compared to that of traditional Sanger sequencing and matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF), twenty-four strains of closely related dermatophytes, Trichophyton rubrum, T...
April 25, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29692458/antimicrobial-susceptibility-of-tinea-capitis-in-children-from-egypt
#11
Reham William Doss, Abdel-Aziz El-Rifaie, Nagla Radi, Aya Yehia El-Sherif
Background: Dermatophytic fungi of genera Trichophyton and Microsporum are the most important fungal species causing tinea capitis. Choice of treatment for tinea capitis is determined by the species of fungus. Aim: The aim of the study was to investigate the most prevalent fungal species causing tinea capitis in children from Egypt and the most useful antifungal agent for treatment. Patients and Methods: A total of 100 patients diagnosed clinically with tinea capitis were included in the study...
March 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29692456/a-study-of-onychomycosis-at-a-tertiary-care-hospital-in-eastern-bihar
#12
Anindita Sen, Deblina Bhunia, Pijush Kanti Datta, Atanu Ray, Parthajit Banerjee
Background: Onychomycosis (OM) is a major public health problem which is increasing worldwide. It is associated with high morbidity and causes physical, psychological, and occupational problems in patients. Aims: This study aims to study the pattern of etiological agents, clinical features, and severity assessment of OM in this part of India. Materials and Methods: Sixty eight clinically suspected patients with positive potassium hydroxide and fungal culture were studied...
March 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29683287/the-role-of-biofilms-in-onychomycosis
#13
Aditya K Gupta, Kelly A Foley
Onychomycosis is a difficult to treat fungal infection of the nails. The chronic nature of onychomycosis contributes to high recurrence rates and the difficulty in treating both dermatophyte and non- dermatophyte infections. It has been hypothesized that the formation of biofilms, sessile, multicellular communities of fungi surrounded by a protective extracellular matrix, allow for fungi to evade current antifungal therapies and contribute to observed antifungal resistance. This review presents the experimental evidence that has accumulated in recent years implicating biofilms in the pathogenesis of onychomycosis...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29679385/genus-level-identification-of-dermatophytes-by-maldi-tof-ms-after-two-days-of-colony-growth
#14
Jari Intra, Cecilia Sarto, Natalia Tiberti, Silvia Besana, Cinzia Savarino, Paolo Brambilla
Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) is becoming a popular technology in clinical microbiology. It is a fast and highly specific method for the routine identification of microorganisms. In this study, we evaluated the suitability of dermatophyte identification after only two days of colony growth using MALDI-TOF MS. Two protein extraction protocols were also evaluated consisting of either formic acid alone or of ethanol-formic acid-acetonitrile to achieve a complete protein extraction...
April 21, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29664175/evaluation-of-the-value-of-staining-hair-samples-with-a-modified-wright-giemsa-stain-and-or-showing-illustrated-guidelines-for-the-microscopic-diagnosis-of-dermatophytosis-in-cats
#15
Rareş Căpitan, Carlo Schievano, Chiara Noli
BACKGROUND: Direct examination of the hair is a simple diagnostic test for the diagnosis of dermatophytosis; training is needed to use this test. HYPOTHESIS/OBJECTIVES: To evaluate whether use of modified Wright-Giemsa blue stain and/or photographic images of infected and uninfected hairs improved the user's ability to identify infected or uninfected hairs. ANIMALS: Ten cats with, and 10 cats without, dermatophytosis due to Microsporum canis (n = 20)...
April 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29657238/the-first-report-of-terbinafine-resistance-microsporum-canis-from-a-cat
#16
Yun-Hsia Hsiao, Charles Chen, Hock Siew Han, Rui Kano
A 2-year-old, exotic shorthair cat presented with baldness and mild scaling on trunk that was confirmed as Microsporum canis (M. canis) infection by the following methods. Wood's lamp and trichogram were used to demonstrate fungal elements suggestive of dermatophytosis consistent with M. canis. Dermatophyte test medium (DTM) and polymerase chain reaction (PCR) were used for identification. E-test and broth microdilution test were then utilized to estimate antifungal minimal inhibitory concentrations (MICs) towards ITZ and TRF respectively...
April 16, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29650464/clioquinol-an-alternative-antimicrobial-agent-against-common-pathogenic-microbe
#17
Z You, X Ran, Y Dai, Y Ran
Skin and soft tissue infections (SSTIs) are very common in dermatology and the use of antimicrobial formulations are important in treating these diseases. With the increasing of drug-resistant strains, researchers need to find ways to enhance the effectiveness and/or reduce the drug resistance. Clioquinol was one of antiseptics that can inactivate microbes. It was lack of data of antimicrobial activity; meanwhile it was infrequently used in infection. In order to research the antimicrobial spectrum and activity of topical 3% clioquinol cream among common pathogenic microorganisms compared with other common topical pharmaceuticals, we used modified agar diffusion assay to judge drug susceptibility and compared with broth microdilution assay...
April 10, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29644200/antifungal-efficacy-of-amphotericin-b-against-dermatophytes-and-its-relevance-in-recalcitrant-dermatophytoses-a-commentary
#18
Surabhi Sinha, Kabir Sardana
No abstract text is available yet for this article.
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29644192/is-antifungal-resistance-a-cause-for-treatment-failure-in-dermatophytosis-a-study-focused-on-tinea-corporis-and-cruris-from-a-tertiary-centre
#19
Kabir Sardana, Ravinder Kaur, Pooja Arora, Ritu Goyal, Sneha Ghunawat
Background: Dermatophytoses are one of the most common skin diseases that have been largely simple to treat. However, in recent years, these infections have become recalcitrant to treatment which can possibly be due to antifungal resistance. Aim: To analyze the resistance pattern of patients with recalcitrant dermatophytoses. Materials and Methods: A cross-sectional evaluation was undertaken of 40 consecutive patients with recalcitrant tinea corporis/cruris/both who had taken systemic antifungal treatment and did not respond completely to therapy or had recurrent lesion within 1 month of stopping the therapy...
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29620451/flavonoids-from-plinia-cauliflora-mart-kausel-myrtaceae-with-antifungal-activity
#20
Tatiana M Souza-Moreira, Juliana A Severi, Edvânio Ramos Rodrigues, Mayara Ivani de Paula, Jolindo A Freitas, Wagner Vilegas, Rosemeire C L R Pietro
Plinia cauliflora is a plant species with edible fruits but its chemical composition is not totally known yet although former studies showed its potential as antifungal agent. This work aimed the chemical analysis of the leaves, the activity against fungi species and evaluated cytotoxicity. Extract was obtained with 70% ethanol. An ethyl acetate fraction was obtained and glycosylated quercetin and myricetin were isolated. Samples were tested against Candida species, dermatophytes and entomopathogenic fungi...
April 5, 2018: Natural Product Research
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