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Dermatophyte

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https://www.readbyqxmd.com/read/29323069/recurrent-dermatophytosis-a-rising-problem-in-sikkim-a-himalayan-state-of-india
#1
Rekha Sharma, Luna Adhikari, Rukma Lall Sharma
Changing pattern of dermatophytic infection among people of Sikkim over the past few years and its recurrence rate has brought a need to do a study on clinical pattern and its recurrence from this part of the country. The objectives of this study are to discern the clinical patterns of dermatophytosis, identification of the isolated fungi to its species level and to see the pattern of its recurrence. The study was carried out from January 2015 to May 2016. A total of 192 samples were collected from the patients with clinical findings of dermatophytic infection...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29314692/molekulare-epidemiologie-von-trichophyton-quinckeanum-ein-zoophiler-dermatophyt-im-aufwind
#2
Silke Uhrlaß, Wieland Schroedl, Carolin Mehlhorn, Constanze Krüger, Vit Hubka, Thomas Maier, Yvonne Gräser, Uwe Paasch, Pietro Nenoff
No abstract text is available yet for this article.
January 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29314679/molecular-epidemiology-of-trichophyton-quinckeanum-a-zoophilic-dermatophyte-on-the-rise
#3
Silke Uhrlaß, Wieland Schroedl, Carolin Mehlhorn, Constanze Krüger, Vit Hubka, Thomas Maier, Yvonne Gräser, Uwe Paasch, Pietro Nenoff
BACKGROUND: Formerly only referred to as a subspecies (T. mentagrophytes var. quinckeanum), T. quinckeanum once again constitutes a distinct species according to the updated taxonomy of dermatophytes. PATIENTS AND METHODS: During routine diagnostic tests conducted at the Mycology Laboratory, Mölbis, Germany, between 11/2013 to 1/2017 (three years and three months), all specimens sent in were examined for T. quinckeanum. Molecular biology methods employed included: 1) DNA hybridization (PCR ELISA), 2) gene sequencing of the ITS region and TEF-1α, and 3) in some cases, MALDI-TOF mass spectrometry...
January 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29314351/epidemiology-of-dermatophyte-infections-among-school-children-in-menoufia-governorate-egypt
#4
Azza G A Farag, Mostafa A Hammam, Reda A Ibrahim, Reda Z Mahfouz, Nada F Elnaidany, Masroor Qutubuddin, Rehab R E Tolba
BACKGROUND: Most superficial mycotic infections of human skin are due to dermatophytes. Children are frequently affected due to different predisposing factors, particularly overcrowding in classrooms. OBJECTIVES: To estimate the prevalence of dermatophytes infections and their related risk factors among school children in Menoufia Governorate, Egypt. SUBJECTS AND METHODS: Six public primary and preparatory schools were randomly selected and their pupils (n= 3464) were asked to complete a predesigned questionnaire covering both personal data and suspected risk factors for superficial dermatophyte infections...
January 4, 2018: Mycoses
https://www.readbyqxmd.com/read/29304214/biofilms-and-beyond-expanding-echinocandin-utility
#5
Emily L Larkin, Sharvari Dharmaiah, Mahmoud A Ghannoum
Echinocandins have been in use for over 15 years, starting with the first approval in 2001. Current trends, such as increasing resistance to fluconazole and shifts toward non-albicans spp. of Candida, suggest a growing role for echinocandins, as reflected by recent (2016) updates to guidelines that recommend echinocandins as first-line treatment for candidaemia. The efficacy, tolerability, and safety of echinocandins and their target site of action (1,3-β-d-glucan synthesis) have prompted research into potential new uses, such as for treatment of biofilm infections, MDR Candida auris and dermatophytes...
January 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29285801/tinea-faciei-in-a-central-portuguese-hospital-a-9-year-survey
#6
Ana Borges, Ana Brasileiro, Célia Galhardas, Margarida Apetato
Tinea faciei is a relatively uncommon dermatophytosis that affects the glabrous skin of the face. The aim of this study was to analyse the epidemiologic, clinical and mycological features of tinea faciei cases diagnosed at the Dermatology and Venereology Department of Hospital Santo António dos Capuchos (Lisbon, Portugal). Consecutive cases diagnosed between 2008 and 2016 were studied retrospectively. A total of 72 tinea faciei cases have been diagnosed, involving 37 male and 35 female, aged between 8 months and 86 years...
December 28, 2017: Mycoses
https://www.readbyqxmd.com/read/29283454/design-development-and-optimization-of-a-transungual-duple-nail-lacquer-for-onychomycosis-therapy
#7
Nazia Hasan, Manvi Singh, Sufiyanu Sulaiman, Shyamasree Nandy, Mridu Dudeja, Asgar Ali, Zeenat Iqbal
Onychomycosis is a degenerative fungal infection inflicting toes and finger nails which is caused by both dermatophytes and non-dermatophytes such as Trichophyton rubrum and Candida spp. respectively. The infection apparently causes nail mutilation making nails stiff, skinny, flawed, and dyschromic. Owing to the anatomical presentation of the disease, a topical application is warranted which asserts positive attributes like ease of preparation, improved adherence, negligible drug interactions, low systemic adverse effects and voluntary removal...
December 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29277007/singlet-oxygen-luminescence-kinetics-under-pdi-relevant-conditions-of-pathogenic-dermatophytes-and-molds
#8
Tobias Bornhütter, Nedaa Shamali, Irena Saltsman, Atif Mahammed, Zeev Gross, Georg Däschlein, Beate Röder
A treatment of onychomycosis using the photodynamic effect would be a favorable alternative to currently used antimycotic drugs. This study should be considered as a first step towards development and control of an efficient photodynamic inactivation of onychomycosis causative pathogens. Here, we evaluate the usage of time-resolved 2D singlet oxygen luminescence detection in combination with 2D fluorescence scanning as a tool to understand the behavior of the photosensitizer when applied to fungi on Petri dishes...
December 14, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29243825/dermatologic-manifestations-among-human-immunodeficiency-virus-patients-in-morocco-and-association-with-immune-status
#9
Hicham Titou, Christelle Ebongo, Naoufal Hjira
OBJECTIVE: The objective was to determine if the type and number of skin diseases can be clinical indicators of underlying immune status in HIV1 disease by estimating and correlating with the CD4 count and CDC stage. MATERIALS AND METHODS: This was a retrospective cross-sectional descriptive study. All consecutive patients infected with HIV1 followed at the Dermatology Department of Rabat Military Hospital between January 2008 and January 2017 were studied for dermatological manifestations, CD4 count and CDC clinical stage...
December 15, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29240863/long-term-follow-up-of-onychomycosis-patients-treated-with-efinaconazole
#10
Richard A Pollak, Carla Ilie
Onychomycosis is a common disease that remains difficult to treat despite the introduction of new topical agents. Clinical trials on efinaconazole and tavaborole included 48 weeks' daily treatment regimens with a 4-week follow-up. It has been suggested that either a longer treatment regimen or longer follow-up would lead to even better results, primarily due to the time taken for the diseased nail to grow out, especially in those patients with more severe disease. <p>OBJECTIVE: To investigate the impact of a longer follow-up period on the efficacy of efinaconazole 10% topical solution in patients with moderate-to-severe onychomycosis...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240047/synthesis-and-dft-calculations-of-novel-vanillin-chalcones-and-their-3-aryl-5-4-2-dimethylamino-ethoxy-3-methoxyphenyl-4-5-dihydro-1h-pyrazole-1-carbaldehyde-derivatives-as-antifungal-agents
#11
Luis Alberto Illicachi, Joel José Montalvo-Acosta, Alberto Insuasty, Jairo Quiroga, Rodrigo Abonia, Maximiliano Sortino, Susana Zacchino, Braulio Insuasty
Novel (E)-1-(aryl)-3-(4-(2-(dimethylamino)ethoxy)-3-methoxyphenyl) prop-2-en-1-ones 4 were synthesized by a Claisen-Schmidt reaction of 4-(2-(dimethylamino)ethoxy)-3-methoxy-benzaldehyde (2) with several acetophenone derivatives 3. Subsequently, cyclocondensation reactions of chalcones 4 with hydrazine hydrate afforded the new racemic 3-aryl-5-(4-(2-(dimethylamino)ethoxy)-3-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehydes 5 when the reaction was carried out in formic acid. The antifungal activity of both series of compounds against eight fungal species was determined...
September 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29228309/prp8-intein-in-dermatophytes-evolution-and-species-identification
#12
Hans Garcia Garces, Raquel Theodoro Cordeiro, E Bagagli
Dermatophytes are keratinophilic fungi belonging to the family Arthrodermataceae. Despite having a monophyletic origin, its systematics has always been complex and controversial. Sequencing of nuclear ribosomal ITS and D1/D2 rDNA has been proposed as an efficient tool for identifying species in this group of fungi, while multilocus analyses have been used for phylogenetic species recognition. However, the search for new markers, with sequence and size variation, which enable species identification in only one polymerase chain reaction (PCR) step, is very attractive...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29220431/in-silico-characterization-of-tandem-repeats-in-trichophyton-rubrum-and-related-dermatophytes-provides-new-insights-into-their-role-in-pathogenesis
#13
Matheus Eloy Franco, Tamires Aparecida Bitencourt, Mozart Marins, Ana Lúcia Fachin
http://comp.mch.ifsuldeminas.edu.br/dtrdb/.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29214894/phenolic-content-and-in-vitro-antifungal-activity-of-unripe-grape-extracts-from-agro-industrial-wastes
#14
Giovanna Simonetti, Felicia Diodata D'Auria, Nadia Mulinacci, Rosa Anna Milella, Donato Antonacci, Marzia Innocenti, Gabriella Pasqua
The antifungal activity of unripe grape extracts from agro-industrial wastes has been evaluated against several strains of Candida spp. and dermatophytes. All the extracts tested showed antifungal activity. The geometric mean MIC ranged from 53.58 to 214.31 μg/mL for Candida spp. and from 43.54 to 133.02 μg/mL for dermatophytes. The chemical analyses have been carried out using Liquid Chromatograph equipped with a DAD and MS detectors. Flavan-3-ols were the main metabolites within all samples ranged from 3...
December 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29208175/antifungal-activity-of-silver-nanoparticles-on-fluconazole-resistant-dermatophytes-identified-by-gaca-4-and-isolated-from-primary-school-children-suffering-from-tinea-capitis-in-ismailia-egypt
#15
Mariam E Amin, Marwa M Azab, Amro M Hanora, Salah Abdalla
Fungal infections caused by dermatophytes recently became more common. Available antifungal drugs are limited because of emergence of resistant strains due to prophylaxis with them, so there is an urgent need for novel antifungals. This study is aimed to detect the antifungal activity of silver nanoparticles (SNPs) on Fluconazole resistant dermatophytes isolated from primary school children clinically suffering from tinea capitis and attending El-Sheikh Zaid Dermatology Center in Ismailia. The study was done on 112 clinical cases...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29201105/synthesis-characterization-and-biological-activity-studies-on-fanlizhicyclopeptide-a
#16
Rajiv Dahiya, Sunil Singh
The synthesis of a proline-rich cyclic heptapeptide, fanlizhicyclopeptide A (8), previously isolated from the fruits of Annona squamosa (sugar-apples), is described via coupling of tetrapeptide -prolyl--tyrosyl--leucyl--proline methyl ester with tripeptide Boc-glycyl--valyl--proline followed by cyclization of the linear fragment having seven amino acid units. Structure of the synthesized cyclooligopeptide was confirmed by the means of chemical and spectroscopic methods including FTIR, 1H NMR, 13C NMR, FABMS and further, subjected to the anthelmintic, antibacterial and the antifungal activity studies...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29198783/common-child-and-adolescent-cutaneous-infestations-and-fungal-infections
#17
Sherman J Alter, Megan B McDonald, Julie Schloemer, Ryan Simon, Julian Trevino
Cutaneous infections and infestations are common among children and adolescents. Ectoparasitic infestations affect individuals across the globe. Head lice, body lice, scabies, and infestations with bed bugs are seen in individuals who reside in both resource poor areas and in developed countries. Superficial cutaneous and mucosal candida occur throughput the life cycle. Dermatophyte infections of keratin-containing skin and skin structures result in tinea capitis (scalp), tinea corporis (body), tinea pedis (foot), and tinea unguium (nails)...
November 30, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29198426/luliconazole-a-new-antifungal-against-candida-species-isolated-from-different-sources
#18
S Taghipour, N Kiasat, S Shafiei, M Halvaeezadeh, A Rezaei-Matehkolaei, A Zarei Mahmoudabadi
OBJECTIVE: Luliconazole is an inhibitor for sterol 14-α-demethylase in fungal cells with a broad-spectrum antifungal activity against dermatophytes, Candida albicans, Malassezia species, dematiaceous and hyaline hyphomycetes. Furthermore, luliconazole has been clinically used for the treatment of pityriasis versicolor, dermatophytosis, onychomycosis, cutaneous and mucocutaneous candidiasis. In the present study, we aimed to evaluate in vitro antifungal activity of luliconazole against several strains of Candida species recovered from different clinical materials...
November 29, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29193594/complete-cure-of-fusarium-solani-sp-complex-onychomycosis-with-qs-ndyag-treatment
#19
Ananta Khurana, Anuradha Chowdhary, Kabir Sardana, R K Gautam, P K Sharma
The incidence of non dermatophytic mould (NDM) onychomycosis (OM) has been steadily increasing Fusarium spp is the most common cause of NDM OM in most geographical locations. Fusarium spp and other NDMs are largely resistant to commonly used anti-fungals. The successful use of laser and light based devices has been demonstrated in dermatophytic OM, but there is no previous report of their successful use in any NDM OM. We describe a patient with OM caused by Fusarium solani spp, who was clinically (with a normal appearing nail) and mycologically (with negative microscopy and culture on repeated samples) cured of her infection following treatment with 2 sessions of Qs NdYAG (532nm and 1064nm) given 1 month apart...
November 28, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29188057/subungual-onychomycosis-due-to-aspergillus-niger-mimicking-a-glomus-tumor-a-case-report
#20
Yumi Matsuyama, Tomoki Nakamura, Tomohito Hagi, Kunihiro Asanuma, Akihiro Sudo
Onychomycosis is a common nail infection caused by dermatophytes, while non-dermatophytes including Aspergillus spp. are causes of nail onychomycosis. Aspergillus niger is not common as a cause of nail onychomycosis. In the current study we present a 60-year-old woman with subungual onychomycosis due to Aspergillus niger mimicking a glomus tumor. Physical examination revealed right thumb had a black color of nail bed. Localized tenderness and severe pain were observed. However, the cold sensitivity test, Loves pin test and Hildreths test were negative...
December 2017: Biomedical Reports
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