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Dermatophyte

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https://www.readbyqxmd.com/read/28066103/efficacy-and-tolerability-of-topical-sertaconazole-versus-topical-terbinafine-in-localized-dermatophytosis-a-randomized-observer-blind-parallel-group-study
#1
Dattatreyo Chatterjee, Sudip Kumar Ghosh, Sukanta Sen, Saswati Sarkar, Avijit Hazra, Radharaman De
OBJECTIVE: Epidermal dermatophyte infections most commonly manifest as tinea corporis or tinea cruris. Topical azole antifungals are commonly used in their treatment but literature suggests that most require twice-daily application and provide lower cure rates than the allylamine antifungal terbinafine. We conducted a head-to-head comparison of the effectiveness of the once-daily topical azole, sertaconazole, with terbinafine in these infections. MATERIALS AND METHODS: We conducted a randomized, observer-blind, parallel group study (Clinical Trial Registry India [CTRI]/2014/09/005029) with adult patients of either sex presenting with localized lesions...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28053148/inhibition-of-dermatophytes-by-photodynamic-treatment-with-curcumin
#2
Jochen Brasch, Sandra Freitag-Wolf, Vera Beck-Jendroschek, Martin Huber
Treatment of dermatophytoses with currently available antimycotic agents is often tedious and sometimes unsatisfactory. A search for better therapeutic methods-ideally with an immediate fungicidal effect-has, among others, lead to photodynamic procedures as a promising alternative, and recently curcumin was found to be a suitable agent for this application. In this study the effect of photodynamic treatment with curcumin on dermatophytes was tested in vitro Wells of microtiter plates were filled with conidia of Trichophyton rubrum, Trichophyton interdigitale, Trichophyton terrestre, Microsporum canis, Microsporum gypseum and Epidermophyton floccosum in buffer...
January 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28040418/-trichophyton-tonsurans-associated-with-non-albicans-candida-species-in-hands-onychomycosis-about-a-moroccan-case
#3
S Kouara, B Ait Hlilou, A Abbadi, H Khalki, I Benbella, K Lahmadi, M Er-Rami
INTRODUCTION: Trichophyton tonsurans is an anthropophilic dermatophyte, frequent in the USA and in Asia where it is responsible for causing tinea capitis. At present, we attend an emergence of this species in certain regions where it was not or little met. Here, we report a case of onychomycosis of the hand due to T. tonsurans associated with non-albicans Candida species at an adult woman. OBSERVATION: The patient is a 62-year-old woman, with hypertension and diabetes...
December 28, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28034734/preparation-and-evaluation-of-a-novel-dosage-form-for-onychomycosis
#4
Flavia Laffleur, Martin Ataii
Onychomycosis is a common infection of the nail caused by dermatophyte affecting mostly toenails in adults being associated with limited treatment options. In this study novel dosage forms were prepared and evaluated for their suitability in treatment of onychomycosis. Films were prepared comprising polymeric excipients such as chitosan, (hydroxypropyl)methyl cellulose, hydroxyethyl-cellulose, carboxymethylcellulose according to solvent evaporation method. Developed formulations were evaluated in terms of physical appearance, stability and adhesiveness...
December 26, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28003819/clinicomycological-characterization-of-superficial-mycoses-from-a-tertiary-care-hospital-in-nepal
#5
Sundar Khadka, Jeevan Bahadur Sherchand, Dinesh Binod Pokharel, Bharat Mani Pokhrel, Shyam Kumar Mishra, Subhash Dhital, Basista Rijal
Background. Superficial mycosis is a common fungal infection worldwide, mainly caused by dermatophytes. However, the prevalence of species varies geographically. In addition, fungal treatment is best guided according to species isolated. This study was carried out to determine the clinical as well as mycological profile of superficial mycoses in a tertiary care hospital, Nepal. Methods. This was a prospective case-control laboratory based study conducted over a period of six months from January to June 2014 at Tribhuvan University Teaching Hospital, Nepal...
2016: Dermatology Research and Practice
https://www.readbyqxmd.com/read/27983681/first-total-synthesis-and-biological-screening-of-a-proline-rich-cyclopeptide-from-a-caribbean-marine-sponge
#6
Rajiv Dahiya, Sunil Singh, Ajay Sharma, Suresh V Chennupati, Sandeep Maharaj
A natural heptacyclopeptide, stylissamide G (7), previously isolated from the Bahamian marine sponge Stylissa caribica from the Caribbean Sea, was synthesized via coupling of the tetrapeptide l-phenylalanyl-l-prolyl-l-phenylalanyl-l-proline methyl ester with the tripeptide Boc-l-leucyl-l-isoleucyl-l-proline, followed by cyclization of the linear heptapeptide fragment. The structure of the synthesized cyclooligopeptide was confirmed using quantitative elemental analysis, FT-IR, ¹H NMR, (13)C NMR and mass spectrometry...
December 15, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27976095/biological-activity-of-16-south-african-plants-with-potential-efficacy-against-dermatophytes
#7
J Rambaldi, A Zaghini, A S Ahmed, F S Botha, L McGaw, J N Eloff
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27972286/a-cost-minimization-analysis-of-dermatophyte-test-kit-with-onychomycosis-under-health-care-system-in-japan
#8
R Watanabe, A Igarashi, H Wakamoto, H Osawa
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27957659/erratum-to-reappraisal-of-conventional-diagnosis-for-dermatophytes
#9
Marc Pihet, Yohann Le Govic
No abstract text is available yet for this article.
December 12, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27956429/in-vitro-antifungal-susceptibility-profile-of-12-antifungal-drugs-against-55-trichophyton-schoenleinii-isolated-from-tinea-capitis-favosa-in-iran-turkey-and-china
#10
Shuwen Deng, Saham Ansari, Macit Ilkit, Haleh Rafati, Mohammad T Hedayati, Mojtaba Taghizadeh-Armaki, Ayatollah Nasrollahi-Omran, Ali Tolooe, Ping Zhan, Wanqing Liao, Henrich A van der Lee, Paul E Verweij, Seyedmojtaba Seyedmousavi
Trichophyton schoenleinii is an anthropophilic dermatophyte mainly causing tinea favosa of the scalp in certain regions of the world, especially Africa and Asia. We investigated the in vitro susceptibilities of 55 T. schoenleinii collected over the last thirty years from Iran, Turkey and China against 12 antifungals using the CLSI broth-microdilution method. Our results revealed that terbinafine and ketoconazole were the most potent antifungal agents among those tested, independent of the geographical regions isolated...
12, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27938809/acral-manifestations-of-fungal-infections
#11
Zekayi Kutlubay, Gürkan Yardımcı, A Serda Kantarcıoğlu, Server Serdaroğlu
Fungal infections, which are named according to the body site involved, can affect any skin area, the fingernails, or the toenails. Numerous fungal agents are responsible for both superficial and deep fungal diseases. Dermatophytes and Candida spp are the most common causative organisms on the surface of the hands, feet, and nails of patients with superficial fungal diseases; however, although deep fungal infections of the skin are less common compared with superficial fungal diseases, their incidence is increasing worldwide due to cross-border travel...
January 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/27935915/medication-practice-of-patients-with-dermatophytosis
#12
Y Poudyal, S D Joshi
INTRODUCTION: Dermatophytosis is one of the commonest dermatoses observed in Dermatology OPD. It is caused by Fungus Dermatophyte. Its pattern and prevalence varies from region to region. As self medication practice is very common, we aim to find the prevalence of various clinical pattern of dermatophytosis and to find out the medication commonly used by the patients for this condition. METHODS: This was cross sectional observational study. The case collection was done from outpatient department of Dermatology and Venereology of a Teaching Hospital from 15th March, 2013 to 14 March, 2014...
July 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27922587/tinea-incognito-due-to-trichophyton-mentagrophytes-case-report
#13
Camila Quiñones, Paula Hasbún, Walter Gubelin
Tineas are frequent infections caused by dermatophytes that are able to invade keratinized tissue, causing rounded, erythematous, scaly lesions. Nonetheless, in tinea incognito the lesions are modified because of inappropriate use of topical corticosteroids or calcineurin inhibitors, making it difficult to diagnose. We present a case of a 12-year-old male child that presents with erythematous lesions on the right eyebrow, which at first was diagnosed as a contact dermatitis, so corticosteroids were indicated...
November 9, 2016: Medwave
https://www.readbyqxmd.com/read/27907185/antioxidant-antimicrobial-and-cytotoxic-properties-as-well-as-the-phenolic-content-of-the-extract-from-hancornia-speciosa-gomes
#14
Uilson P Santos, Jaqueline F Campos, Heron Fernandes V Torquato, Edgar Julian Paredes-Gamero, Carlos Alexandre Carollo, Leticia M Estevinho, Kely de Picoli Souza, Edson Lucas Dos Santos
Hancornia speciosa Gomes (Apocynaceae) is a fruit tree, popularly known as mangabeira, and it is widely distributed throughout Brazil. Several parts of the plant are used in folk medicine, and the leaf and bark extracts have anti-inflammatory, antihypertensive, antidiabetic, and antimicrobial properties. In this study, we investigated the chemical composition of the ethanolic extract of Hancornia speciosa leaves (EEHS) and its antioxidant, antimicrobial, and cytotoxic activities as well as the mechanisms involved in cell death...
2016: PloS One
https://www.readbyqxmd.com/read/27904057/potential-of-ravuconazole-and-its-prodrugs-as-the-new-oraltherapeutics-for-onychomycosis
#15
Hideyo Yamaguchi
Onychomycosis is a fungal infection of the nail apparatus caused by dermatophytes, Candida and non-dermatophytic molds. It is highly prevalent in the general population worldwide and also responsible for significant morbidity and complications and does not usually cure itself. Thus, the condition needs to be treated in view of physical and psychological problems produced. Currently, oral medications using terbinafine are the most effective therapy, but it has relatively limited therapeutic success, particularly for long-term management...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27904054/epidemiology-of-dermatophytoses-in-crete-greece
#16
Sofia Maraki, Viktoria Eirini Mavromanolaki
Dermatophytoses are among the most frequently diagnosed skin infections worldwide. However, the distribution of pathogenic species and the predominating anatomical sites of infection vary with geographical location and change over time. The aim of this study was to determine the epidemiological and aetiological factors of dermatophytoses in Crete, Greece over the last 5-year period (2011-2015) and their incidence in relation to the gender and the age of the patients. We compared our findings with those previously reported from the same area and from other parts of the world...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27890967/airborne-pollen-and-fungal-spores-in-garki-abuja-north-central-nigeria
#17
Dimphna Nneka Ezike, Catherine V Nnamani, Oluwatoyin T Ogundipe, Olushola H Adekanmbi
The ambient atmosphere is dominated with pollen and spores, which trigger allergic reactions and diseases and impact negatively on human health. A survey of pollen and fungal spores constituents of the atmosphere of Garki, Abuja (North-Central Nigeria) was carried out for 1 year (June 1, 2011-May 31, 2012). The aim of the study was to determine the prevalence and abundance of pollen and fungal spores in the atmosphere and their relationship with meteorological parameters. Airborne samples were trapped using modified Tauber-like pollen trap, and the recipient solutions were subjected to acetolysis...
2016: Aerobiologia
https://www.readbyqxmd.com/read/27878642/are-th17-cells-playing-a-role-in-immunity-to-dermatophytosis
#18
Marie-Pierre Heinen, Ludivine Cambier, Laurence Fievez, Bernard Mignon
Despite their superficial localization in the skin, pathogenic dermatophytes can induce a complex but still misunderstood immune response in their hosts. The cell-mediated immunity (CMI) is correlated with both clinical recovery and protection against reinfection, and CD4+ T lymphocytes have been recognized as a crucial component of the immune defense against dermatophytes. Before the discovery of the Th17 pathway, CMI was considered to be only dependent of Th1 cells, and thus most studies on the immunology of dermatophytosis have focused on the Th1 pathway...
November 23, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27876749/anti-fungal-activity-of-ctn-15-34-the-c-terminal-peptide-fragment-of-crotalicidin-a-rattlesnake-venom-gland-cathelicidin
#19
Carolina Sidrim P Cavalcante, Cláudio B Falcão, Raquel Os Fontenelle, David Andreu, Gandhi Rádis-Baptista
Crotalicidin (Ctn), a 34-residue cathelicidin from a South American rattlesnake, and its fragment (Ctn[15-34]) have shown anti-infective and cytotoxic activities against Gram-negative bacteria and certain tumor lines, respectively. The extent of such effects has been related to physicochemical characteristics such as helicity and hydrophobicity. We now report the anti-fungal activity of Ctn and its fragments (Ctn[1-14]) and (Ctn[15-34]). MIC determination and luminescent cell viability assays were used to evaluate the anti-infective activity of Ctn and its fragments (Ctn[1-14]) and (Ctn[15-34]) as anti-fungal agents against opportunistic yeast and dermatophytes...
November 23, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27876085/onychomycosis-in-diabetic-patients-in-fako-division-of-cameroon-prevalence-causative-agents-associated-factors-and-antifungal-sensitivity-patterns
#20
Marvlyn Eba, Anna Longdoh Njunda, Rene Njikam Mouliom, Emmanuel Tebit Kwenti, Anold Nsoh Fuh, Gordon Takop Nchanji, Julius Atashili
BACKGROUND: Onychomycosis is an infection of the nail unit by a fungus. This is a very common infection amongst diabetics. Its occurrence among diabetics in Fako division is unknown. In this study we provide information on the characteristics of onychomycosis in diabetics in Fako division, Cameroon. METHODS: A cross-sectional descriptive and analytical hospital-based study was conducted in two diabetic clinics in the Buea and Limbe regional hospitals. We recruited 152 consenting diabetics into the study...
November 22, 2016: BMC Research Notes
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