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https://www.readbyqxmd.com/read/28815713/clinical-winnicott-traveling-a-revolutionary-road
#1
Vincenzo Bonaminio
The author contends that, contrary to the usual perception that Winnicott followed a linear progression "through pediatrics to psychoanalysis," Winnicott's vision was always a psychoanalytic one, even during his early pediatric work. His place in the development of psychoanalytic theory is highlighted, and the author discusses such key Winnicottian concepts as transitional space, the false self, and the use of the object. Winnicott's unique approach to the form and value of analytic interpretation is particularly emphasized, and his thoughts on the treatment of depression are also addressed, as well as his distinction between regression and withdrawal...
July 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/28805685/re-adaption-on-earth-after-spaceflights-affects-the-mouse-liver-proteome
#2
Viktoria Anselm, Svetlana Novikova, Victor Zgoda
Harsh environmental conditions including microgravity and radiation during prolonged spaceflights are known to alter hepatic metabolism. Our studies have focused on the analysis of possible changes in metabolic pathways in the livers of mice from spaceflight project "Bion-M 1". Mice experienced 30 days of spaceflight with and without an additional re-adaption period of seven days compared to control mice on Earth. To investigate mice livers we have performed proteomic profiling utilizing shotgun mass spectrometry followed by label-free quantification...
August 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28805053/heterogeneous-photochemistry-of-agrochemicals-at-leaf-surface-a-case-study-of-plant-activator-acibenzolar-s-methyl
#3
Mohamad Sleiman, Pascal de Sainte Claire, Claire Richard
The photoreactivity of plant activator benzo-(1,2,3)-thiadiazole-7-carbothioic acid S-methyl ester (BTH) commonly named acibenzolar-S-methyl was studied on surfaces of glass, paraffinic wax films and apple leaves. Experiments were carried out in a solar simulator using pure and formulated BTH (BION®). Surface photoproducts were identified using liquid chromatography coupled with electrospray ionization and high resolution Orbitrap mass spectrometer, while volatile photoproducts were characterized using an online thermal desorption system coupled to gas chromatography-mass spectrometry (GC-MS)...
August 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28776654/the-latency-complex-the-dead-hand-of-anti-development
#4
Barry D Proner
It is common knowledge that the same phenomena can be viewed in a variety of ways. This paper considers the implications of a constellation observed in some adult patients who have increasingly reminded the author of some of the children of latency age with whom he has also worked. In the literature these patients may also have been thought about in terms of 'defences of the self' (Fordham), patients who are 'difficult to reach' (Joseph), 'psychic retreats' (Steiner), and those who make 'attacks on linking' (Bion)...
September 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28751192/evidence-of-an-inverse-correlation-between-serotonergic-activity-and-spreading-depression-propagation-in-the-rat-cortex
#5
Rubem Carlos Araújo Guedes, Maria das Graças Rodrigues Araújo, Taciana Cristovam Verçosa, Francisca Martins Bion, Andrea Lima de Sá, Antônio Pereira, Ricardo Abadie-Guedes
Various neurological and psychiatric diseases lead to alterations in cortical serotonergic activity as one of their underlying processes. However, the electrophysiological implication of changes in serotonergic activity remains a matter of investigation. In this study, we investigated whether brain serotonergic activity influences the excitability-related phenomenon known as cortical spreading depression (CSD). CSD parameters (propagation velocity, and amplitude and duration of the DC-shift) was evaluated in rats that received two treatments that increased cortical serotonergic activity, electrical stimulation of the raphe nuclei and subcutaneous injection of a selective serotonin reuptake inhibitor, sumatriptan...
July 24, 2017: Brain Research
https://www.readbyqxmd.com/read/28723146/generalized-noise-study-of-solid-state-nanopores-at-low-frequencies
#6
Chenyu Wen, Shuangshuang Zeng, Kai Arstila, Timo Sajavaara, Yu Zhu, Zhen Zhang, Shi-Li Zhang
Nanopore technology has been extensively investigated for analysis of biomolecules, and a success story in this field concerns DNA sequencing using a nanopore chip featuring an array of hundreds of biological nanopores (BioNs). Solid-state nanopores (SSNs) have been explored to attain longer lifetime and higher integration density than what BioNs can offer, but SSNs are generally considered to generate higher noise whose origin remains to be confirmed. Here, we systematically study low-frequency (including thermal and flicker) noise characteristics of SSNs measuring 7 to 200 nm in diameter drilled through a 20-nm-thick SiNx membrane by focused ion milling...
February 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28710944/effect-of-acibenzolar-s-methyl-phototransformation-on-its-elicitation-activity-in-tobacco-cells
#7
Florent Lavergne, Claire Richard, Marc Saudreau, Jean-Stéphane Venisse, Boris Fumanal, Pascale Goupil
The plant activator acibenzolar-S-methyl (BTH) undergoes phototransformation when exposed to solar radiation. Here we investigated the changes in its elicitation properties on BY-2 tobacco cells at different stages of the photochemical reaction. Both pure BTH and formulated BTH were irradiated in controlled conditions to achieve different extents of conversion. Both pure BTH (900 μM) and Bion(®) (0.4 g.L(-1)) induced BY-2 cell death, but BTH photoconverted to an extent of 25 ± 3% lowered the cell death rate...
July 8, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28607344/surviving-sepsis-campaign-guidelines-2016-omission-of-selective-decontamination-of-the-digestive-tract-deprives-patients-of-a-level-2b-therapy
#8
Luciano Silvestri, Hendrick K van Saene, Johannes H Rommes, Andy J Petros, Miguel A de la Cal, Julian F Bion
No abstract text is available yet for this article.
June 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28590761/proteome-wide-adaptations-of-mouse-skeletal-muscles-during-a-full-month-in-space
#9
Georg Tascher, Thomas Brioche, Pauline Maes, Angèle Chopard, Donal O'Gorman, Guillemette Gauquelin-Koch, Stéphane Blanc, Fabrice Bertile
The safety of space flight is challenged by a severe loss of skeletal muscle mass, strength, and endurance that may compromise the health and performance of astronauts. The molecular mechanisms underpinning muscle atrophy and decreased performance have been studied mostly after short duration flights and are still not fully elucidated. By deciphering the muscle proteome changes elicited in mice after a full month aboard the BION-M1 biosatellite, we observed that the antigravity soleus incurred the greatest changes compared with locomotor muscles...
June 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28572612/one-month-spaceflight-compromises-the-bone-microstructure-tissue-level-mechanical-properties-osteocyte-survival-and-lacunae-volume-in-mature-mice-skeletons
#10
Gerbaix Maude, Gnyubkin Vasily, Farlay Delphine, Olivier Cécile, Ammann Patrick, Courbon Guillaume, Laroche Norbert, Gential Rachel, Follet Hélène, Peyrin Françoise, Shenkman Boris, Gauquelin-Koch Guillemette, Vico Laurence
The weightless environment during spaceflight induces site-specific bone loss. The 30-day Bion-M1 mission offered a unique opportunity to characterize the skeletal changes after spaceflight and an 8-day recovery period in mature male C57/BL6 mice. In the femur metaphysis, spaceflight decreased the trabecular bone volume (-64% vs. Habitat Control), dramatically increased the bone resorption (+140% vs. Habitat Control) and induced marrow adiposity invasion. At the diaphysis, cortical thinning associated with periosteal resorption was observed...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28554506/bion-m-1-first-continuous-blood-pressure-monitoring-in-mice-during-a-30-day-spaceflight
#11
Alexander Andreev-Andrievskiy, Anfisa Popova, Jean-Christophe Lloret, Patrick Aubry, Anatoliy Borovik, Daria Tsvirkun, Olga Vinogradova, Eugeniy Ilyin, Guillemette Gauquelin-Koch, Claude Gharib, Marc-Antoine Custaud
Animals are an essential component of space exploration and have been used to demonstrate that weightlessness does not disrupt essential physiological functions. They can also contribute to space research as models of weightlessness-induced changes in humans. Animal research was an integral component of the 30-day automated Russian biosatellite Bion-M 1 space mission. The aim of the hemodynamic experiment was to estimate cardiovascular function in mice, a species roughly 3000 times smaller than humans, during prolonged spaceflight and post-flight recovery, particularly, to investigate if mice display signs of cardiovascular deconditioning...
May 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28542871/interpretation-as-freud-s-specific-action-and-bion-s-container-contained
#12
Chris Mawson
This is a paper showing how a concept central to the work of Wilfred Bion, and one of Klein's important recommendations concerning the practice of analysis with adults and small children, can both be seen in the light of Freud's earliest formulation of the origin of anxiety and the mother's first responses to her infant in distress. In the paper I suggest that these clinically influential concepts of Klein and Bion show an underlying consistency and affinity with Freud's early ideas about the management of anxiety in the mother-infant relationship, described in two of his pre-psychoanalytic writings, How Anxiety Originates (1894b), and The Project for a Scientific Psychology (1950 [1895])...
May 25, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28529490/microgravity-induced-transcriptome-adaptation-in-mouse-paraspinal-longissimus-dorsi-muscle-highlights-insulin-resistance-linked-genes
#13
Guido Gambara, Michele Salanova, Stefano Ciciliot, Sandra Furlan, Martina Gutsmann, Gudrun Schiffl, Ute Ungethuem, Pompeo Volpe, Hanns-Christian Gunga, Dieter Blottner
Microgravity as well as chronic muscle disuse are two causes of low back pain originated at least in part from paraspinal muscle deconditioning. At present no study investigated the complexity of the molecular changes in human or mouse paraspinal muscles exposed to microgravity. The aim of this study was to evaluate longissimus dorsi adaptation to microgravity at both morphological and global gene expression level. C57BL/N6 male mice were flown aboard the BION-M1 biosatellite for 30 days (BF) or housed in a replicate flight habitat on ground (BG)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28490091/physico-chemical-characterization-of-dairy-gel-obtained-by-a-proteolytic-extract-from-calotropis-procera-a-comparison-with-chymosin
#14
Issa Ado Rayanatou, ElHadji Gounga Mahamadou, Gilles Garric, Marielle Harel-Oger, Arlette Leduc, Julien Jardin, Valérie Briard-Bion, Chantal Cauty, Hassane Adakal, Jean François Grongnet, Frédéric Gaucheron
Chymosin is the major enzyme used in cheesemaking but latex enzymes are also used. The aim of this work was to characterize the composition and the structure of dairy gel obtained by an extract of Calotropis procera leaves in comparison with those obtained by chymosin. The biochemical and mineral compositions of the curds and the cheese yields obtained by using Calotropis procera extract or chymosin were relatively similar. Quantitative and qualitative evaluations of proteolysis after milk coagulation, determined by the non-protein nitrogen content and chromatography coupled to mass spectrometry, indicated that Calotropis procera extract was more proteolytic than chymosin and that κ-casein was proteolyzed...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28437539/safety-and-efficacy-of-antiviral-therapy-for-prevention-of-cytomegalovirus-reactivation-in-immunocompetent-critically-ill-patients-a-randomized-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Nicholas J Cowley, Andrew Owen, Sarah C Shiels, Joanne Millar, Rebecca Woolley, Natalie Ives, Husam Osman, Paul Moss, Julian F Bion
Importance: Latent cytomegalovirus (CMV) infection is present in more than half the adult population, and a viral reactivation (ie, when the virus becomes measurable in body fluids such as blood) can occur in up to one-third of these individuals during episodes of critical illness. Objective: To determine whether antiviral therapy is safe and effective for preventing CMV reactivation in a general population of critically ill patients. Design, Setting, and Participants: A single-center, open-label, randomized, controlled clinical trial recruited 124 CMV-seropositive patients undergoing mechanical ventilation for at least 24 hours in the intensive care unit between January 1, 2012, and January 31, 2014...
June 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28406170/identification-of-proteins-involved-in-the-anti-inflammatory-properties-of-propionibacterium-freudenreichii-by-means-of-a-multi-strain-study
#16
Stéphanie-Marie Deutsch, Mahendra Mariadassou, Pierre Nicolas, Sandrine Parayre, Rozenn Le Guellec, Victoria Chuat, Vincent Peton, Caroline Le Maréchal, Julien Burati, Valentin Loux, Valérie Briard-Bion, Julien Jardin, Coline Plé, Benoît Foligné, Gwénaël Jan, Hélène Falentin
Propionibacterium freudenreichii, a dairy starter, can reach a population of almost 10(9) propionibacteria per gram in Swiss-type cheese at the time of consumption. Also consumed as a probiotic, it displays strain-dependent anti-inflammatory properties mediated by surface proteins that induce IL-10 in leukocytes. We selected 23 strains with varied anti-inflammatory potentials in order to identify the protein(s) involved. After comparative genomic analysis, 12 of these strains were further analysed by surface proteomics, eight of them being further submitted to transcriptomics...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28398923/the-association-between-visiting-intensivists-and-icu-outcomes
#17
MULTICENTER STUDY
Tony Whitehouse, James Hodson, Philip Pemberton, Tonny Veenith, Catherine Snelson, Julian Bion, Gordon D Rubenfeld
OBJECTIVES: We hypothesized that intensivists unfamiliar with an ICU team and the context of that ICU would affect patient outcomes. We examined differences in mortality when ICU patients were admitted under intensivists routinely working in that ICU and compared with those admitted by intensivists familiar with an ICU elsewhere in the same hospital. DESIGN, SETTINGS, AND PATIENTS: A 5-year natural experimental crossover study involving patients admitted to four ICUs in a large U...
June 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28385913/the-weekend-effect-in-acute-medicine-a-protocol-for-a-team-based-ethnography-of-weekend-care-for-medical-patients-in-acute-hospital-settings
#18
Carolyn Tarrant, Elizabeth Sutton, Emma Angell, Cassie P Aldridge, Amunpreet Boyal, Julian Bion
INTRODUCTION: It is now well-recognised that patients admitted to hospital on weekends are at higher risk of death than those admitted during weekdays. However, the causes of this 'weekend effect' are poorly understood. Some contend that there is a deficit of medical staff on weekends resulting in poorer quality care, whereas others find that patients admitted to hospital on weekends are sicker and therefore at higher risk of adverse outcomes. Clarifying the causal pathway is clearly important in order to identify effective solutions...
April 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28322090/the-chemical-inducer-bth-benzothiadiazole-and-root-colonization-by-mycorrhizal-fungi-glomus-spp-trigger-resistance-against-white-rot-sclerotinia-sclerotiorum-in-sunflower
#19
Rita Bán, Gellért Baglyas, Ferenc Virányi, Balázs Barna, Katalin Posta, József Kiss, Katalin Körösi
White rot caused by Sclerotinia sclerotiorum (SS) is one of the most devastating plant diseases of sunflower. Controlling this pathogen by available tools hardly result in acceptable control. The aim of this study was to elucidate the effects of plant resistance inducers, BTH (benzothiadiazole in Bion 50 WG) and arbuscular mycorrhizal fungi (AMF) on disease development of white rot in three sunflower genotypes. Defence responses were characterized by measuring the disease severity and identifying cellular/histological reactions (e...
March 2017: Acta Biologica Hungarica
https://www.readbyqxmd.com/read/28243916/myeloid-precursors-in-the-bone-marrow-of-mice-after-a-30-day-space-mission-on-a-bion-m1-biosatellite
#20
E V Sotnezova, E A Markina, E R Andreeva, L B Buravkova
The content of myeloid stem CFU in bone marrow karyocytes from the tibial bone of C57Bl/6 mice was evaluated after a 30-day Bion-M1 pace flight/ground control experiment and subsequent 7-day recovery period. After the space flight, we observed a significant decrease in the number of erythroid progenitors in the bone marrow, including common myeloid precursor - granulocyte, erythrocyte, monocyte/macrophage, megakaryocyte CFU. After 7-day readaptation, CFU level in flight animals did not recover completely. In the ground control, the count of erythroid burst-forming units was higher than in vivarium animals...
February 2017: Bulletin of Experimental Biology and Medicine
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