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Post natal depression

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https://www.readbyqxmd.com/read/27831486/ontogeny-of-net-expression-and-antidepressant-like-response-to-desipramine-in-wild-type-and-sert-mutant-mice
#1
Nathan C Mitchell, Melodi A Bowman, Georgianna G Gould, Wouter Koek, Lynette C Daws
Depression is a major public health concern with symptoms that are often poorly controlled by treatment with common antidepressants. This problem is compounded in juveniles and adolescents, where therapeutic options are limited to only two approved antidepressants, both selective serotonin reuptake inhibitors (SSRIs). Moreover, therapeutic benefits of SSRIs are often especially limited in certain subpopulations of depressed patients, including children and carriers of low expressing serotonin transporter (SERT) gene variants...
November 9, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27814521/the-central-nervous-system-and-the-gut-microbiome
#2
REVIEW
Gil Sharon, Timothy R Sampson, Daniel H Geschwind, Sarkis K Mazmanian
Neurodevelopment is a complex process governed by both intrinsic and extrinsic signals. While historically studied by researching the brain, inputs from the periphery impact many neurological conditions. Indeed, emerging data suggest communication between the gut and the brain in anxiety, depression, cognition, and autism spectrum disorder (ASD). The development of a healthy, functional brain depends on key pre- and post-natal events that integrate environmental cues, such as molecular signals from the gut...
November 3, 2016: Cell
https://www.readbyqxmd.com/read/27756349/depression-an-exploratory-parallel-group-randomised-controlled-trial-of-antenatal-guided-self-help-for-women-dawn-study-protocol-for-a-randomised-controlled-trial
#3
Kylee Trevillion, Jill Domoney, Andrew Pickles, Debra Bick, Sarah Byford, Margaret Heslin, Jeannette Milgrom, Rachel Mycroft, Carmine Pariante, Elizabeth Ryan, Myra Hunter, Louise Michele Howard
BACKGROUND: Depression is a common antenatal mental disorder and is associated with an increased risk of adverse effects on the fetus and significant morbidity for the mother; if untreated it can also continue into the post-natal period and affect mother-infant interactions. There has been little research evaluating the effectiveness or cost-effectiveness of antenatal psychological interventions for antenatal depression, particularly for mild to moderate disorders. International guidelines recommend a stepped care approach starting with Guided Self Help, and the aim of this exploratory trial is to investigate Guided Self Help modified for pregnancy...
October 18, 2016: Trials
https://www.readbyqxmd.com/read/27660558/recognition-and-management-of-perinatal-depression-and-anxiety-by-general-practitioners-a-systematic-review
#4
Elizabeth Ford, Judy Shakespeare, Fatin Elias, Susan Ayers
BACKGROUND: Perinatal anxiety and depression are widespread, with up to 20% of women affected during pregnancy and after birth. In the UK, management of perinatal mental health falls under the remit of general practitioners (GPs). We reviewed the literature on GPs' routine recognition, diagnosis and management of anxiety and depression in the perinatal period. METHOD: A systematic search of Embase, Medline, PsycInfo, Pubmed, Scopus and Web of Science was conducted...
September 22, 2016: Family Practice
https://www.readbyqxmd.com/read/27658457/the-association-between-maternal-and-partner-experienced-racial-discrimination-and-prenatal-perceived-stress-prenatal-and-postnatal-depression-findings-from-the-growing-up-in-new-zealand-cohort-study
#5
Laia Bécares, Polly Atatoa-Carr
BACKGROUND: A growing number of studies document the association between maternal experiences of racial discrimination and adverse children's outcomes, but our understanding of how experiences of racial discrimination are associated with pre- and post-natal maternal mental health, is limited. In addition, existent literature rarely takes into consideration racial discrimination experienced by the partner. METHODS: We analysed data from the Growing Up in New Zealand study to examine the burden of lifetime and past year experiences of racial discrimination on prenatal and postnatal mental health among Māori, Pacific, and Asian women in New Zealand (NZ), and to study the individual and joint contribution of mother's and partner's experiences of lifetime and past year racial discrimination to women's prenatal and postnatal mental health...
September 22, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27561997/mothers-perinatal-and-infant-mental-health-knowledge-in-a-johannesburg-township-setting
#6
Katherine Bain, Jade Richards
OBJECTIVE: This paper examines maternal knowledge regarding perinatal and infant mental health amongst mothers in Alexandra township, Johannesburg. The applicability and utility of these Western-derived concepts in a low socio-economic South African setting is examined. METHOD: A concurrent mixed methods approach was used. Descriptive statistical analysis was conducted on the responses of 255 mothers on a structured questionnaire, designed to elicit levels of knowledge about the relational needs and awareness of infants and the psychosocial needs of mothers, to determine trends in mothers' knowledge...
July 2016: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/27518778/the-challenges-of-a-successful-pregnancy-in-a-patient-with-adult-refsum-s-disease-due-to-phytanoyl-coa-hydroxylase-deficiency
#7
Karolina M Stepien, Anthony S Wierzbicki, Bwee T Poll-The, Hans R Waterham, Christian J Hendriksz
We describe the management and outcomes of pregnancy in a 27-year-old woman with infantile-onset Adult Refsum's disease (ARD). She presented in infancy but was diagnosed with ARD at the age of 10 on basis of phytanic acidaemia and later confirmed to have the phytanoyl-CoA hydroxylase ((PHYH) c.164delT, p.L55fsX12) mutation. Despite repeated plasmapheresis sessions and strict dietary surveillance for 20 years, her phytanic acid levels persistently stayed above the ideal target level of 100 μmol/L but remained below 400 μmol/L...
August 13, 2016: JIMD Reports
https://www.readbyqxmd.com/read/27338722/posttraumatic-stress-disorder-following-stillbirth-trauma-characteristics-locus-of-control-posttraumatic-cognitions
#8
Man Cheung Chung, Jacqueline Reed
This study examined the incidence of PTSD and psychiatric co-morbidity among women who experienced stillbirth and investigated the relationship between locus of control, trauma characteristics of stillbirth, posttraumatic cognitions, PTSD and co-morbid psychiatric symptoms following stillbirth. Fifty women recorded information on stillbirth experiences, and completed the Posttraumatic Stress Diagnostic Scale, General Health Questionnaire-28, Edinburgh Post-natal Depression Scale, Rotter's Locus of Control Scale and the Posttraumatic Cognitions Inventory...
June 23, 2016: Psychiatric Quarterly
https://www.readbyqxmd.com/read/27209204/molecular-and-behavioral-profiling-of-dbx1-derived-neurons-in-the-arcuate-lateral-and-ventromedial-hypothalamic-nuclei
#9
Katie Sokolowski, Tuyen Tran, Shigeyuki Esumi, Yasmin Kamal, Livio Oboti, Julieta Lischinsky, Meredith Goodrich, Andrew Lam, Margaret Carter, Yasushi Nakagawa, Joshua G Corbin
BACKGROUND: Neurons in the hypothalamus function to regulate the state of the animal during both learned and innate behaviors, and alterations in hypothalamic development may contribute to pathological conditions such as anxiety, depression or obesity. Despite many studies of hypothalamic development and function, the link between embryonic development and innate behaviors remains unexplored. Here, focusing on the embryonically expressed homeodomain-containing gene Developing Brain Homeobox 1 (Dbx1), we explored the relationship between embryonic lineage, post-natal neuronal identity and lineage-specific responses to innate cues...
2016: Neural Development
https://www.readbyqxmd.com/read/27073881/pre-and-post-natal-maternal-depressive-symptoms-in-relation-with-infant-frontal-function-connectivity-and-behaviors
#10
Ni Ni Soe, Daniel J Wen, Joann S Poh, Yue Li, Birit F P Broekman, Helen Chen, Yap Seng Chong, Kenneth Kwek, Seang-Mei Saw, Peter D Gluckman, Michael J Meaney, Anne Rifkin-Graboi, Anqi Qiu
This study investigated the relationships between pre- and early post-natal maternal depression and their changes with frontal electroencephalogram (EEG) activity and functional connectivity in 6- and 18-month olds, as well as externalizing and internalizing behaviors in 24-month olds (n = 258). Neither prenatal nor postnatal maternal depressive symptoms independently predicted neither the frontal EEG activity nor functional connectivity in 6- and 18-month infants. However, increasing maternal depressive symptoms from the prenatal to postnatal period predicted greater right frontal activity and relative right frontal asymmetry amongst 6-month infants but these finding were not observed amongst 18-month infants after adjusted for post-conceptual age on the EEG visit day...
2016: PloS One
https://www.readbyqxmd.com/read/26924315/lifelong-nutritional-omega-3-deficiency-evokes-depressive-like-state-through-soluble-beta-amyloid
#11
Maria Grazia Morgese, Paolo Tucci, Emanuela Mhillaj, Maria Bove, Stefania Schiavone, Luigia Trabace, Vincenzo Cuomo
Recent evidence pointed out that the prevalence of depression has reached epidemic proportions in last decades. This increase has been linked to many environmental factors, among these the influence of dietary factors has gained great attention. In particular, it has been reported that low n-3 polyunsaturated fatty acid (n-3 PUFA) intake in diet is correlated to the development of depressive and anxiety-like symptoms. Furthermore, maternal malnutrition is a widely accepted risk factor for developing mental illness in later adulthood; among others, depression has been strongly associated to this event...
February 29, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26887958/evaluation-of-an-antenatal-acupuncture-intervention-as-an-adjunct-therapy-for-antenatal-depression-acuantedep-study-protocol-for-a-pragmatic-randomised-controlled-trial
#12
Simone M Ormsby, Caroline A Smith, Hannah G Dahlen, Phillipa J Hay, Joanne M Lind
BACKGROUND: Depressed pregnant women face difficulty navigating a course between the potentially serious consequences of leaving depression untreated and significant limitations associated with conventional therapies, such as foetal toxicity and teratogenicity. Preliminary evidence is suggestive that acupuncture may provide a safe and effective alternative treatment option for antenatal depression; however, additional research is required. The purpose of this study is to further investigate this treatment possibility, with an additional examination of a potential biomechanistic acupuncture effect...
2016: Trials
https://www.readbyqxmd.com/read/26725347/antenatal-dietary-patterns-and-depressive-symptoms-during-pregnancy-and-early-post-partum
#13
Rachel Baskin, Briony Hill, Felice N Jacka, Adrienne O'Neil, Helen Skouteris
Perinatal depression is a debilitating disorder experienced during pregnancy and/or the first year post-partum. Recently, maternal dietary intake during pregnancy has emerged as a possible area of intervention for the prevention of mental disorders in women and their offspring. However, the relationship between antenatal diet quality and perinatal depressive symptoms remains poorly understood. The current study explored the predictive role of antenatal diet quality for antenatal and post-natal depressive symptoms...
January 3, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/26619275/dopamine-d3-receptor-mediates-preadolescent-stress-induced-adult-psychiatric-disorders
#14
Joon H Seo, Eldo V Kuzhikandathil
Several studies have shown that repeated stressful experiences during childhood increases the likelihood of developing depression- and anxiety-related disorders in adulthood; however, the underlying mechanisms are not well understood. We subjected drd3-EGFP and drd3-null mice to daily, two hour restraint stress episodes over a five day period during preadolescence (postnatal day 35 to 39), followed by social isolation. When these mice reached adulthood (post-natal day > 90), we assessed locomotor behavior in a novel environment, and assessed depression-related behavior in the Porsolt Forced Swim test...
2015: PloS One
https://www.readbyqxmd.com/read/26581673/the-long-term-effects-of-methamphetamine-exposure-during-pre-adolescence-on-depressive-like-behaviour-in-a-genetic-animal-model-of-depression
#15
Moné Mouton, Brian H Harvey, Marike Cockeran, Christiaan B Brink
Methamphetamine (METH) is a psychostimulant and drug of abuse, commonly used early in life, including in childhood and adolescence. Adverse effects include psychosis, anxiety and mood disorders, as well as increased risk of developing a mental disorder later in life. The current study investigated the long-term effects of chronic METH exposure during pre-adolescence in stress-sensitive Flinders Sensitive Line (FSL) rats (genetic model of depression) and control Flinders Resistant Line (FRL) rats. METH or vehicle control was administered twice daily from post-natal day 19 (PostND19) to PostND34, followed by behavioural testing at either PostND35 (early effects) or long-lasting after withdrawal at PostND60 (early adulthood)...
February 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/26469300/are-female-children-more-vulnerable-to-the-long-term-effects-of-maternal-depression-during-pregnancy
#16
Catherine Quarini, Rebecca M Pearson, Alan Stein, Paul G Ramchandani, Glyn Lewis, Jonathan Evans
BACKGROUND: Female fetuses are more vulnerable to high levels of maternal glucocorticoids. We examined whether exposure to prenatal maternal depression, a condition associated with high glucocorticoids, carries greater risk for depression at 12 and 18 years in girls. METHODS: Our sample comprised 7959 mothers and children from the Avon Longitudinal Study of Parents and Children following imputation for missing data. Maternal depression was assessed pre-and post-natally, and offspring depression at ages 12 and 18...
January 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26334739/treatment-failure-drug-resistance-and-cd4-t-cell-count-decline-among-postpartum-women-on-antiretroviral-therapy-in-south-africa
#17
Christopher J Hoffmann, Silvia Cohn, Fildah Mashabela, Jennifer D Hoffmann, Helen McIlleron, Paolo Denti, David W Haas, Kelly E Dooley, Neil A Martinson, Richard E Chaisson
BACKGROUND: We assessed HIV RNA suppression, resistance, and CD4 T-cell count 12 months postpartum among pregnant women retained in care in an observational cohort study. METHODS: We prospectively followed two groups of HIV-infected pregnant women--with or without tuberculosis--recruited from prenatal clinics in South Africa. Women who received antiretroviral therapy during pregnancy and reported being on therapy 12 months postpartum were included. Serum samples from women with HIV viremia 12 months postpartum were tested for drug resistance...
January 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/26298809/emotional-impact-of-severe-post-partum-haemorrhage-on-women-and-their-partners-an-observational-case-matched-prospective-single-centre-pilot-study
#18
Aude Ricbourg, Christelle Gosme, Etienne Gayat, Chloé Ventre, Emmanuel Barranger, Alexandre Mebazaa
OBJECTIVE: This observational, matched-control, prospective, single-centre study sought to estimate the emotional impact of post-partum haemorrhage (PPH) on women and their partners, including its influences on post-traumatic stress disorder (PTSD), postpartum depression and the mother/child relationship. STUDY DESIGN: All consecutive women who were admitted for PPH from December 2010 through December 2011 and their partners were screened for eligibility. Emotional impact was assessed using three self-reported questionnaires (Impact of Event Scale-Revised to assess PTSD, Edinburgh Post Natal Depression Scale to assess post-natal depression and Mother-Infant Bonding Scale to assess the relationship between mother and child)...
October 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/26209211/efficacy-of-physical-activity-interventions-in-post-natal-populations-systematic-review-meta-analysis-and-content-coding-of-behaviour-change-techniques
#19
REVIEW
Alyssa Sara Gilinsky, Hannah Dale, Clare Robinson, Adrienne R Hughes, Rhona McInnes, David Lavallee
This systematic review and meta-analysis reports the efficacy of post-natal physical activity change interventions with content coding of behaviour change techniques (BCTs). Electronic databases (MEDLINE, CINAHL and PsychINFO) were searched for interventions published from January 1980 to July 2013. Inclusion criteria were: (i) interventions including ≥1 BCT designed to change physical activity behaviour, (ii) studies reporting ≥1 physical activity outcome, (iii) interventions commencing later than four weeks after childbirth and (iv) studies including participants who had given birth within the last year...
2015: Health Psychology Review
https://www.readbyqxmd.com/read/26190973/seeking-homeostasis-temporal-trends-in-respiration-oxidation-and-calcium-in-sod1-g93a-amyotrophic-lateral-sclerosis-mice
#20
Cameron W Irvin, Renaid B Kim, Cassie S Mitchell
Impairments in mitochondria, oxidative regulation, and calcium homeostasis have been well documented in numerous Amyotrophic Lateral Sclerosis (ALS) experimental models, especially in the superoxide dismutase 1 glycine 93 to alanine (SOD1 G93A) transgenic mouse. However, the timing of these deficiencies has been debatable. In a systematic review of 45 articles, we examine experimental measurements of cellular respiration, mitochondrial mechanisms, oxidative markers, and calcium regulation. We evaluate the quantitative magnitude and statistical temporal trend of these aggregated assessments in high transgene copy SOD1 G93A mice compared to wild type mice...
2015: Frontiers in Cellular Neuroscience
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