keyword
https://read.qxmd.com/read/38531243/a-study-on-the-treatment-of-brain-tumors-with-bnct-using-several-moderators-with-different-thicknesses
#1
JOURNAL ARTICLE
Yinan Zhu, Zuokang Lin, Haiyan Yu, Xiaohan Yu
Boron neutron capture therapy (BNCT) is an effective binary radiation therapy that depends on nuclear capture reactions. In recent years, BNCT can be performed without a reactor owing to the development of accelerator-based neutron sources. A new BNCT irradiation facility is proposed, which is based on a 15 mA 2.5 MeV proton accelerator with a 100 μm thickness natural lithium target as a neutron converter. A great quantity of studies has shown that neutron beams with different spectra have unique therapeutic effects on tumors...
March 22, 2024: Applied Radiation and Isotopes
https://read.qxmd.com/read/38530497/how-effective-are-mood-stabilizers-in-treating-bipolar-patients-comorbid-with-cptsd-results-from-an-observational-study
#2
JOURNAL ARTICLE
Anna Maria Iazzolino, Marta Valenza, Martina D'Angelo, Grazia Longobardi, Valeria Di Stefano, Steardo Luca, Caterina Scuderi, Luca Steardo
BACKGROUND: Multiple traumatic experiences, particularly in childhood, may predict and be a risk factor for the development of complex post-traumatic stress disorder (cPTSD). Unfortunately, individuals with bipolar disorder (BP) are more likely to have suffered traumatic events than the general population. Consequently, cPTSD could be comorbid with BD, and this may negatively affect psychopathological manifestations. To date, no one has explored whether such comorbidity also affects the response to treatment with mood stabilizers in BD patients...
March 26, 2024: International Journal of Bipolar Disorders
https://read.qxmd.com/read/38517222/new-pharmacotherapies-to-tackle-the-unmet-needs-in-bipolar-disorder-a-focus-on-acute-suicidality
#3
REVIEW
Georgios D Kotzalidis, Federica Fiaschè, Alessandro Alcibiade, Laura Monti, Federica Di Segni, Marianna Mazza, Gabriele Sani
INTRODUCTION: Suicidal behavior is relatively frequent in patients with bipolar disorder (BD) and constitutes their most frequent cause of death. Suicide rates remain high in patients with BD despite adherence to guidelines recommending lithium as first line, and/or antidepressants, antipsychotics, psychotherapy, psychosocial interventions, and electroconvulsive therapy. Hence the need to identify more effective and rapid anti-suicide interventions. AREAS COVERED: To tackle the unmet needs of pharmacotherapy, we investigated the PubMed database on 24-25 January 2024 using strategies like ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (lithium[ti] OR clozapine[ti]), which obtained 3 results, and ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (ketamine[ti] OR esketamine[ti] OR NMDA[ti] OR glutamat*[ti]), which yielded 14 results...
March 22, 2024: Expert Opinion on Pharmacotherapy
https://read.qxmd.com/read/38512148/-high-lithium-serum-level-as-maintenance-treatment-of-rapid-cycling-bipolar-disorder
#4
REVIEW
F P N Detmers Blom, M de Leeuw
Bipolar disorder with a rapid cycling course can be difficult to treat, often involving therapy resistance. A 55-year old patient with bipolar disorder with rapid cycling course did not stabilize for years, despite various pharmacotherapeutic treatments. Only after lithium was introduced as a maintenance treatment at a level of around 1.20 mmol/l, a long-term stabilization of mood developed which also persisted. A literature review was performed which concluded that maintenance treatment with lithium at levels above 1...
2024: Tijdschrift Voor Psychiatrie
https://read.qxmd.com/read/38508371/development-and-application-of-hydroxyapatite-based-scaffolds-for-bone-tissue-regeneration-a-systematic-literature-review
#5
REVIEW
Fendi Fendi, Bualkar Abdullah, Sri Suryani, Andi Nilawati Usman, Dahlang Tahir
Hydroxyapatite [HA, Ca10 (PO4 )6 (OH)2 ], with its robust biocompatibility and bioactivity, has found extensive utility in bone grafting, replacement therapies, and supplemental medical materials. HA is highly regarded for its osteoconductive properties because it boasts hydrophilicity, nontoxicity, non-allergenicity, and non-mutagenicity. Nevertheless, HA's intrinsic mechanical weakness has spurred efforts to enhance its properties. This enhancement is achieved through ion incorporation, with elements such as magnesium, zinc, lithium, strontium, boron, and others being integrated into the HA structure...
March 18, 2024: Bone
https://read.qxmd.com/read/38499882/coq10-targeted-hippocampal-ferroptosis-in-a-status-epilepticus-rat-model
#6
JOURNAL ARTICLE
Heba Fikry, Lobna A Saleh, Faten A Mahmoud, Sara Abdel Gawad, Hadwa Ali Abd-Alkhalek
Status epilepticus (SE), the most severe form of epilepsy, leads to brain damage. Uncertainty persists about the mechanisms that lead to the pathophysiology of epilepsy and the death of neurons. Overloading of intracellular iron ions has recently been identified as the cause of a newly recognized form of controlled cell death called ferroptosis. Inhibiting ferroptosis has shown promise as a treatment for epilepsy, according to recent studies. So, the current study aimed to assess the possible antiepileptic impact of CoQ10 either alone or with the standard antiepileptic drug sodium valproate (SVP) and to evaluate the targeted effect of COQ10 on hippocampal oxidative stress and ferroptosis in a SE rat model...
March 19, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38489135/effectiveness-of-ultra-long-term-lithium-treatment-relevant-factors-and-case-series
#7
REVIEW
Ewa Ferensztajn-Rochowiak, Ute Lewitzka, Maria Chłopocka-Woźniak, Janusz K Rybakowski
BACKGROUND: The phenomenon of preventing the recurrences of mood disorders by the long-term lithium administration was discovered sixty years ago. Such a property of lithium has been unequivocally confirmed in subsequent years, and the procedure makes nowadays the gold standard for the pharmacological prophylaxis of bipolar disorder (BD). The efficacy of lithium prophylaxis surpasses other mood stabilizers, and the drug has the longest record as far as the duration of its administration is concerned...
March 15, 2024: International Journal of Bipolar Disorders
https://read.qxmd.com/read/38478641/exacerbation-of-darier-disease-with-lithium-therapy
#8
JOURNAL ARTICLE
Shant Tamazian, Cory L Simpson
Darier disease is an autosomal dominant blistering disorder linked to mutation of the endoplasmic reticulum calcium pump, SERCA2, which compromises keratinocyte adhesion and differentiation. Beyond the typical keratotic and eroded skin lesions, patients with Darier disease often present with psychiatric co-morbidities. Herein, we present a biopsy-confirmed case of Darier disease in a patient with bipolar disorder, whose cutaneous disease dramatically worsened upon initiation of lithium therapy. In consultation with the patient's psychiatrist, lithium was tapered, leading to rapid improvement in her skin...
October 15, 2023: Dermatology Online Journal
https://read.qxmd.com/read/38460603/astaxanthin-treatment-reduces-kidney-damage-and-facilitates-antioxidant-recovery-in-lithium-intoxicated-rats
#9
JOURNAL ARTICLE
Elif Erbaş, Hilal Üstündağ, Emre Öztürk, Seçil Nazife Parlak, Tuğçe Atcalı
OBJECTIVE: This study aimed to evaluate the protective effects of astaxanthin against lithium-induced nephrotoxicity, focusing on histopathological changes, oxidative stress modulation, and alteration in the expression of key proteins related to apoptosis and inflammation. METHODS: In this study, 56 male rats were utilized and divided into experimental groups subjected to lithium-induced nephrotoxicity, with and without astaxanthin treatment, over 14 and 28 days...
March 7, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38428897/fourteen-year-trends-in-prescribing-patterns-for-patients-with-bipolar-mania-discharged-from-a-public-psychiatric-hospital-in-taiwan
#10
JOURNAL ARTICLE
Huei-Ping Chiu, YuJu Shih, Ching-Hua Lin
Bipolar disorder is a complex mental illness. Pharmacological therapy, including antipsychotics and mood stabilizers, is the primary treatment approach for manic episode. The study aimed to analyze prescribing patterns over a 14-year period for patients with bipolar mania discharged from a psychiatric hospital in Taiwan. Patients with bipolar mania discharged from the study hospital between 2006 and 2019 (n = 2956) were included in the analysis. Prescribed drugs for the treatment of manic episode, included mood stabilizers (i...
March 1, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38421397/-history-of-cardiac-pacemaker-therapy-in-germany
#11
REVIEW
Bernd Lemke
Cardiac pacemaker therapy began with successful stimulation of human hearts already in the first half of the 20th century. Complete implantation of a pacemaker by the cardiac surgeon Åke Senning on October 8, 1958 at the Karolinska Hospital in Stockholm is considered the actual birth of today's pacemaker therapy. The first pacemaker implantation in Germany was performed by Hans-Joachim Sykosch on October 6, 1961 at the Surgical Clinic of the University of Düsseldorf. Two years later, the first implantation in East Germany (GDR) was carried out by Friedrich Flemming on September 2, 1963 at the Charité in East Berlin...
February 29, 2024: Herzschrittmachertherapie & Elektrophysiologie
https://read.qxmd.com/read/38394763/cerebrolysin-potentiates-the-antidepressant-effect-of-lithium-in-a-rat-model-of-depression
#12
JOURNAL ARTICLE
Ahmed O Abdelaty, Engy K Tharwat, Alaa I Abdelrahman, Ayatallah Elgohary, Hebatallah Elsaeed, Amena S El-Feky, Yasmina M Ebrahim, Abdelaziz Habib, Hasnaa Abd El Latif, Yasser A Khadrawy, Heba S Aboul Ezz, Neveen A Noor, Heba M Fahmy, Faten F Mohammed, Nasr M Radwan, Nawal A Ahmed
RATIONALE: Depression is the most prevalent psychiatric disorder worldwide. Although numerous antidepressant treatments are available, there is a serious clinical concern due to their severe side effects and the fact that some depressed patients are resistant to them. Lithium is the drug of choice for bipolar depression and has been used as adjunct therapy with other groups of antidepressants. OBJECTIVES: The present study aims to investigate the effect of lithium augmentation with cerebrolysin on the neurochemical, behavioral and histopathological alterations induced in the reserpine model of depression...
February 17, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38389989/hypothyroidism-and-sinus-dysfunction-associated-with-lithium-paliperidone-combination-therapy-for-bipolar-disorder-with-psychotic-symptoms-a-case-report
#13
Wenjian Wei, Yonglan Yang, Haifeng Wang, Yunbin Yang, Jizhou Liu, Jinfeng Li
BACKGROUND AND AIM: Lithium is considered to be the first-line treatment for bipolar disorder, and paliperidone was approved for the treatment of schizophrenia and acute bipolar manic/mixed episodes. However, both agents have been associated with thyroid dysfunction and cardiovascular adverse effects like subclinical hypothyroidism, bradycardia, and sinus arrest, even at therapeutic doses. CASE PRESENTATION: Here, we reported a case of a 17-year-old Han Chinese female who developed symptomatic hypothyroidism, sinus bradycardia, and sinus arrest while being treated with lithium and paliperidone for bipolar disorder with psychotic features including auditory hallucinations...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38382831/magnesium-lithium-thin-films-for-neurological-applications-an-in-vitro-investigation-of-glial-cytocompatibility-and-neuroinflammatory-response
#14
JOURNAL ARTICLE
Krathika Bhat, Luise Schlotterose, Lisa Hanke, Heike Helmholz, Eckhard Quandt, Kirsten Hattermann, Regine Willumeit-Römer
Lithium (Li), a widely used drug for bipolar disorder management, is associated with many side effects due to systemic exposure. The localized delivery of lithium through implants could be an approach to overcome this challenge, for which biodegradable magnesium (Mg)-based materials are a promising choice. In this study, we focus on Mg-Li thin film alloys as potential Li-releasing implants. Therefore, we investigated the in vitro short-term corrosion behavior and cytocompatibility of two alloys, Mg-1.6wt%Li and Mg-9...
February 19, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38381901/prospective-comparative-pilot-study-of-maintenance-treatment-in-comorbid-bipolar-disorders-with-post-traumatic-stress-disorder
#15
JOURNAL ARTICLE
Hernán F Guillen-Burgos, Juan F Gálvez-Flórez, Sergio Moreno-Lopez, Angela T H Kwan, Roger S McIntyre
There is limited real-world evidence that evaluates the impact of monotherapy vs. combination therapy as a maintenance treatment in comorbid post-traumatic stress disorder (PTSD) in bipolar disorder (BD). Our aim was to compare lithium vs. lithium plus quetiapine in maintenance treatment in a sample of comorbid BD with PTSD. An exploratory, comparative pilot study over a 28-week period in 34 comorbid BD with PTSD patients was performed to compare monotherapy (n = 18) vs. combination therapy (n = 16) during maintenance treatment...
February 22, 2024: International Clinical Psychopharmacology
https://read.qxmd.com/read/38374833/chronic-lithium-intoxication-a-challenging-diagnosis
#16
Sofia Ferreira, Sara Santos, Sérgio Gomes Ferreira, Luís Fernandes, Penélope Almeida
Lithium has been used in clinical practice since the 1970s. This medication is commonly used to treat and prevent bipolar disorder, but it has a narrow therapeutic index, making toxicity a frequent occurrence. Chronic lithium intoxication can arise due to progressive accumulation, particularly in contexts of dehydration. The effects of chronic lithium intoxication on the nervous, renal, and cardiac systems, as well as on the thyroid and parathyroid glands, are well documented in the literature. The authors present the case of a 66-year-old woman with schizoaffective psychosis and chronic kidney disease, admitted due to altered mental status and dysarthria...
January 2024: Curēus
https://read.qxmd.com/read/38369441/photosensitive-hydrogels-encapsulating-dpscs-and-agnps-for-dental-pulp-regeneration
#17
JOURNAL ARTICLE
Yan He, Yanni Zhang, Fengting Hu, Min Chen, Ben Wang, Yejian Li, Haichao Xu, Na Dong, Chen Zhang, Yunfan Hu, Zhiqiang Lin, Youjian Peng, Qingsong Ye, Lihua Luo
OBJECTIVE: Pulp regeneration with bioactive dentin-pulp complex has been a research hotspot in recent years. Stem cell therapy provided an interest strategy to regenerate the dental-pulp complex. Hence, this study aimed to evaluate the effects of photosensitive gelatin methacrylate (GelMA) hydrogel encapsulating dental pulp stem cells (DPSCs) and silver nanoparticles (AgNPs) for dental pulp regeneration in vitro. METHODS: First, the AgNPs@GelMA hydrogels were prepared by lithium phenyl-2,4,6-trimethyl-benzoyl phosphinate (LAP) initiation via blue-light emitting diode light...
February 17, 2024: International Dental Journal
https://read.qxmd.com/read/38364913/evolving-therapeutic-interventions-for-the-management-and-treatment-of-alzheimer-s-disease
#18
REVIEW
Faizan Ahmad, Anik Karan, Rashi Sharma, Navatha Shree Sharma, Vaishnavi Sundar, Richard Jayaraj, Sudip Mukherjee, Mark A DeCoster
Alzheimer's Disease (AD) patients experience diverse symptoms, including memory loss, cognitive impairment, behavioral abnormalities, mood changes, and mental issues. The fundamental objective of this review is to discuss novel therapeutic approaches, with special emphasis on recently approved marketed formulations for the treatment of AD, especially Aducanumab, the first FDA approved moiety that surpasses the blood-brain barrier (BBB) and reduces amyloid plaques in the brain, thereby reducing associated cognitive decline...
February 14, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38361653/nephrogenic-diabetes-insipidus-in-a-geriatric-patient-affected-by-sars-cov-2-complexity-of-a-diagnosis-complexity-of-a-virus
#19
Maria Ada Corich, Michele Niero, Lucia Corich, Elisabetta Ferretti, Paolo De Colle, Stella Bernardi, Giuliano Ceschia, Gianfranco Sanson, Michela Zanetti
BACKGROUND: Coronavirus disease 2019 (COVID-19) has an important impact on the kidney through direct and indirect damage mechanisms. Most previous studies have highlighted lesions caused by this virus in the early segments of the nephron. However, due to the antigenic characteristics of the virus, with almost ubiquitous receptors, and the molecular release it triggers, the distal segments of the nephron could also be affected. METHODS: A 71 year-old-man with respiratory failure while suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia presented with typical symptoms of diabetes insipidus after ~20 days of hospitalization...
2024: Access microbiology
https://read.qxmd.com/read/38352640/sinus-node-dysfunction-and-pulmonary-hypertension-double-trouble-with-lithium-therapy
#20
Shweta Vohra, Akshyaya Pradhan, Rishi Sethi, Monika Bhandari
Lithium is considered a gold standard drug for the management of bipolar disorder and is a widely used mood-stabilizing drug in psychiatry practice. However, its side effects are of important concern. The narrow therapeutic index of lithium predispose to its toxicity/side effects, but various case reports and research has shown that adverse drug reactions can occur even in the therapeutic range. We present the case of a 56-year-old woman with no history of cardiac illness presenting with tachycardia-bradycardia syndrome along with moderate pulmonary hypertension...
February 2024: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
keyword
keyword
19413
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.