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Lithium therapy

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https://www.readbyqxmd.com/read/29756288/mixed-states-in-bipolar-and-major-depressive-disorders-systematic-review-and-quality-appraisal-of-guidelines
#1
REVIEW
N Verdolini, D Hidalgo-Mazzei, A Murru, I Pacchiarotti, L Samalin, A H Young, E Vieta, A F Carvalho
OBJECTIVE: This systematic review provided a critical synthesis and a comprehensive overview of guidelines on the treatment of mixed states. METHOD: The MEDLINE/PubMed and EMBASE databases were systematically searched from inception to March 21st, 2018. International guidelines covering the treatment of mixed episodes, manic/hypomanic, or depressive episodes with mixed features were considered for inclusion. A methodological quality assessment was conducted with the Appraisal of Guidelines for Research and Evaluation-AGREE II...
May 13, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29737895/treatment-of-seborrheic-dermatitis-a-comprehensive-review
#2
Luis J Borda, Marina Perper, Jonette E Keri
Seborrheic Dermatitis (SD) is a chronic, recurring inflammatory skin disorder that manifests as erythematous macules or plaques with varying levels of scaling associated with pruritus. The condition typically occurs as an inflammatory response to Malassezia species and tends to occur on seborrheic areas, such as the scalp, face, chest, back, axilla, and groin areas. SD treatment focuses on clearing signs of the disease; ameliorating associated symptoms, such as pruritus; and maintaining remission with long-term therapy...
May 8, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29732913/augmentation-strategies-for-clozapine-refractory-schizophrenia-a-systematic-review-and-meta-analysis
#3
Dan J Siskind, Michael Lee, Arul Ravindran, Qichen Zhang, Evelyn Ma, Balaji Motamarri, Steve Kisely
BACKGROUND: Although clozapine is the most effective medication for treatment refractory schizophrenia, only 40% of people will meet response criteria. We therefore undertook a systematic review and meta-analysis of global literature on clozapine augmentation strategies. METHODS: We systematically reviewed PubMed, PsycInfo, Embase, Cochrane Database, Chinese Biomedical Literature Service System and China Knowledge Resource Integrated Database for randomised control trials of augmentation strategies for clozapine resistant schizophrenia...
May 1, 2018: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29722029/a-regulatory-loop-connecting-wnt-signaling-and-telomere-capping-possible-therapeutic-implications-for-dyskeratosis-congenita
#4
REVIEW
Rafael Jesus Fernandez, F Brad Johnson
The consequences of telomere dysfunction are most apparent in rare inherited syndromes caused by genetic deficiencies in factors that normally maintain telomeres. The principal disease is known as dyskeratosis congenita (DC), but other syndromes with similar underlying genetic defects share some clinical aspects with this disease. Currently, there are no curative therapies for these diseases of telomere dysfunction. Here, we review recent findings demonstrating that dysfunctional (i.e., uncapped) telomeres can downregulate the WNT pathway, and that restoration of WNT signaling helps to recap telomeres by increasing expression of shelterins, proteins that naturally bind and protect telomeres...
April 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29713199/severe-mental-illness-and-chronic-kidney-disease-a-cross-sectional-study-in-the-united-kingdom
#5
Masao Iwagami, Kathryn E Mansfield, Joseph F Hayes, Kate Walters, David Pj Osborn, Liam Smeeth, Dorothea Nitsch, Laurie A Tomlinson
Objective: We investigated the burden of chronic kidney disease (CKD) among patients with severe mental illness (SMI). Methods: We identified patients with SMI among all those aged 25-74 registered in the UK Clinical Practice Research Datalink as on March 31, 2014. We compared the prevalence of CKD (two measurements of estimated glomerular filtration rate <60 mL/min/1.73 m2 for ≥3 months) and renal replacement therapy between patients with and without SMI. For patients with and without a history of lithium prescription separately, we used logistic regression to examine the association between SMI and CKD, adjusting for demographics, lifestyle characteristics, and known CKD risk factors...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29708074/the-relationship-between-lithium-and-cancer-proliferation-a-case-based-review-of-the-literature
#6
Aysegul Ozerdem, Deniz Ceylan, Bilge Targıtay
BACKGROUND: The incidence and mortality rates of cancer in patients with bipolar disorder (BD) is higher compared with the gen-eral population. The role of lithium (Li) in cancer proliferation/inhibition is still a controversial issue in the literature. OBJECTIVE: Based on a clinical case with lithium intake and development of a renal tumor, we aimed to explore the relationship between Li use and tumor proliferation, with regard to the mechanism of action of Li...
April 29, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29668330/book-review-the-science-and-practice-of-lithium-therapy-the-science-and-practice-of-lithium-therapy-malhi-gin-s-masson-marc-bellivier-frank-editors-cham-switzerland-springer-international-2017-179-00-isbn-978-3-319-45923-3-reviewer-rating-good
#7
https://www.readbyqxmd.com/read/29666369/lithium-associated-transcriptional-regulation-of-crmp1-in-patient-derived-olfactory-neurons-and-symptom-changes-in-bipolar-disorder
#8
Charlee K McLean, Soumya Narayan, Sandra Y Lin, Narayan Rai, Youjin Chung, MariaMananita S Hipolito, Nicola G Cascella, John I Nurnberger, Koko Ishizuka, Akira S Sawa, Evaristus A Nwulia
There is growing evidence that lithium used in the treatment of bipolar disorder (BD) affects molecular targets that are involved in neuronal growth, survival, and maturation, but it remains unclear if neuronal alterations in any of these molecules predict specific symptom changes in BD patients undergoing lithium monotherapy. The goals of this study were to (a) determine which molecular changes in the olfactory neurons of symptomatic patients receiving lithium are associated with antimanic or antidepressant response, and (b) uncover novel intraneuronal regulatory mechanisms of lithium therapy...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29663821/lithium-prevents-cell-apoptosis-through-autophagy-induction
#9
H Kazemi, A Noori-Zadeh, S Darabi, F Rajaei
OBJECTIVE: Bone marrow stromal stem cells (BMSCs) are widely used as an available source for cell therapy, tissue engineering, and cellular differentiation-based techniques. Therefore, it is necessary to apply a simple method through which BMSCs can be protected from cell apoptosis under tough conditions of cell differentiation. Lithium treatment is one of the simple methods in this regard. METHODS: The isolated BMSCs were divided into three groups: (a) control, (b) serum deprivation and (c) LiCl...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29611351/effects-of-sildenafil-metformin-and-simvastatin-on-adh-independent-urine-concentration-in-healthy-volunteers
#10
Anneke P Bech, Jack F M Wetzels, Tom Nijenhuis
Nephrogenic diabetes insipidus (NDI) is a rare disorder characterized by resistance of the kidney to the action of antidiuretic hormone (ADH), resulting in a decrease in the capacity of the kidney to concentrate the urine. NDI can be inherited or acquired due to, for example, chronic lithium therapy. Current treatment options are limited to attempts to lower urine output by a low-solute diet and the use of diuretics or anti-inflammatory drugs. These measures are only partially effective. Recent reports suggested that sildenafil, metformin, and simvastatin might improve ADH-independent urine concentration...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29606318/kleine-levin-syndrome-a-neuropsychiatric-disorder
#11
REVIEW
I Arnulf, E Groos, P Dodet
Kleine-Levin syndrome (KLS) is a rare, relapsing-remitting disease that affects mostly adolescents. It is characterized by episodes lasting from 1 to several weeks, and comprises neurological (hypersomnia, confusion, slowness, amnesia) and neuropsychiatric symptoms (derealization and apathy). Some psychiatric symptoms (megaphagia, hypersexuality, anxiety, depressed mood, hallucinations, delusions) arise during episodes, albeit less frequently, while patients are normal between episodes. However, sudden severe (>18h/day of sleep) and recurrent hypersomnia helps to differentiate KLS from other psychiatric mimics...
March 30, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29590494/endocrinopathies-and-renal-outcomes-in-lithium-therapy-impact-of-lithium-toxicity
#12
R Dineen, D Bogdanet, D Thompson, C J Thompson, L A Behan, A P McKay, G Boran, C Wall, J Gibney, V O'Keane, M Sherlock
Background: Lithium is the mainstay of treatment for bipolar disorder, mania and an augmentation therapy in patients with treatment resistant depression. It has a narrow therapeutic index, with recognized adverse multi-system and endocrine side effects. Aim: To assess the impact of lithium therapy, in particular lithium toxicity, on the development of endocrine and renal disorders in a cohort of patients in a single tertiary referral centre in Ireland. Study design: A retrospective analysis was performed of the prevalence of lithium toxicity and renal, thyroid and parathyroid dysfunction in our study population...
December 1, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29571237/an-approach-to-treating-a-patient-with-a-heartmate-ii%C3%A2-left-ventricularassist-device-in-a-multiplace-hyperbaric-chamber-a-case-report
#13
D Orwig, C Logue, S Hendriksen, B Westgard, J Walter, M Pullis, T Masters
Introduction: Left-ventricular assist devices (LVAD) are becoming a common therapy for end-stage heart failure. These devicesare not tested for pressurization in a hyperbaricchamber by the manufacturer. In this article, we present an approach to modify the power supply in order to safely treat a patient with an LVAD. Materials and Methods: Our patient had a HeartMateII™ LVAD and presented for hyperbaric oxygen treatments for severe radiation cystitis. In order to modify this patient's equipment to be compliant with NFPA6 safety standards we made several modifications...
January 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29571151/folate-homeostasis-in-epileptic-rats
#14
Aniv Mann, Emma Portnoy, Hadas Han, Dorrit Inbar, Dana Blatch, Miriam Shmuel, Tamir Ben-Hur, Sara Eyal, Dana Ekstein
Folate is involved in metabolic processes and it has been implicated in both aggravation and amelioration of seizures. The aim of the current work was to study the effect of chronic temporal lobe epilepsy (TLE) on the plasma and brain concentrations of folate and on its uptake carriers in the brain - the reduced folate carrier (RFC), folate receptor α (FRα) and proton coupled folate transporter (PCFT). We utilized the rat lithium pilocarpine model for TLE. Approximately two months following status epilepticus, rats with spontaneous recurrent seizures (SRS) were sacrificed for brain and plasma folate concentration analyses and folate uptake carrier expression studies...
March 16, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29562749/book-review-the-science-and-practice-of-lithium-therapy-the-science-and-practice-of-lithium-therapy-malhi-gin-s-masson-marc-bellivier-frank-editors-cham-switzerland-springer-international-2017-179-00-isbn-978-3-319-45923-3-reviewer-rating-good
#15
https://www.readbyqxmd.com/read/29557625/-lithium-while-breastfeeding-case-report
#16
Miguel A Marín Gabriel, Ana M Malalana Martínez, Ibone Olza Fernández
Lithium therapy is currently a cornerstone of treatment for mothers who suffer bipolar disorders. Those who wish to breastfeed their children are often told they have to decide whether modifying the treatment for their disorder or even avoiding lactation. Lithium administration during breastfeeding has been described to produce certain side effects such as thyroid disorders, hypothermia and hypotonia. To our knowledge, there are few publications where infants have no laboratory abnormalities. Here we present the case of an infant without renal or thyroid alteration while he was breastfed...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29552749/miscellaneous-treatments-for-antipsychotic-induced-tardive-dyskinesia
#17
REVIEW
Karla Soares-Weiser, John Rathbone, Yusuke Ogawa, Kiyomi Shinohara, Hanna Bergman
BACKGROUND: Antipsychotic (neuroleptic) medication is used extensively to treat people with chronic mental illnesses. Its use, however, is associated with adverse effects, including movement disorders such as tardive dyskinesia (TD) - a problem often seen as repetitive involuntary movements around the mouth and face. This review, one in a series examining the treatment of TD, covers miscellaneous treatments not covered elsewhere. OBJECTIVES: To determine whether drugs, hormone-, dietary-, or herb-supplements not covered in other Cochrane reviews on TD treatments, surgical interventions, electroconvulsive therapy, and mind-body therapies were effective and safe for people with antipsychotic-induced TD...
March 19, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29544744/the-impact-of-depression-medications-on-oral-antidiabetic-drug-adherence-in-patients-with-diabetes-and-depression
#18
Shan Xing, Gregory S Calip, Alex D Leow, Shiyun Kim, Glen T Schumock, Daniel R Touchette, Todd A Lee
AIMS: To compare adherence and persistence to oral antidiabetic drugs (OAD) between patients who are new users of second generation antipsychotics (SGA) versus new users of other depression therapies in adults with type 2 diabetes mellitus (T2DM) and major depressive disorder (MDD). METHODS: Adults 18-64 years with previously-treated T2DM and MDD (past OAD and SSRI/SNRI use) who are new users of SGA or non-SGA therapies (bupropion, lithium, mirtazapine, thyroid hormone, tricyclic antidepressant) were identified in the 2009-2015 MarketScan® Commercial Claims and Encounters database...
May 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29540132/royal-australian-and-new-zealand-college-of-psychiatrists-clinical-practice-guidelines-for-mood-disorders-bipolar-disorder-summary
#19
Gin S Malhi, Tim Outhred, Grace Morris, Philip M Boyce, Richard Bryant, Paul B Fitzgerald, Malcolm J Hopwood, Bill Lyndon, Roger Mulder, Greg Murray, Richard J Porter, Ajeet B Singh, Kristina Fritz
In December 2015, the Royal Australian and New Zealand College of Psychiatrists published a comprehensive set of mood disorder clinical practice guidelines for psychiatrists, psychologists and mental health professionals. This guideline summary, directed broadly at primary care physicians, is an abridged version that focuses on bipolar disorder. It is intended as an aid to the management of this complex disorder for primary care physicians working in collaboration with psychiatrists to implement successful long term management...
March 19, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29531810/lithium-induces-mesenchymal-epithelial-differentiation-during-human-kidney-development-by-activation-of-the-wnt-signalling-system
#20
Karen L Price, Maria Kolatsi-Joannou, Chiara Mari, David A Long, Paul J D Winyard
Kidney function is directly linked to the number of nephrons which are generated until 32-36 weeks gestation in humans. Failure to make nephrons during development leads to congenital renal malformations, whilst nephron loss in adulthood occurs in progressive renal disease. Therefore, an understanding of the molecular processes which underlie human nephron development may help design new treatments for renal disease. Mesenchyme to epithelial transition (MET) is critical for forming nephrons, and molecular pathways which control rodent MET have been identified...
December 2018: Cell Death Discovery
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