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https://www.readbyqxmd.com/read/27925220/relationship-between-inner-dialog-and-ideas-of-reference-and-the-mediating-role-of-dissociation
#1
Gloria Bellido-Zanin, Salvador Perona-Garcelán, Cristina Senín-Calderón, Ana María López-Jiménez, Juan Francisco Rodríguez-Testal
Recent lines of research have begun to concentrate on internal dialogue and its relationship to a diversity of psychopathological phenomena present in psychotic disorders. This study was intended as a preliminary exploration of the relationship of internal dialogue, dissociation and ideas of reference. To do this, a sample of 318 students filled in an internal dialogue scale (the VISQ, McCarthy-Jones & Fernyhough), one for dissociation (DES-II, Carlson & Putnam) and another for ideas of reference (REF, Lenzenweger, Bennett & Lilenfeld)...
December 7, 2016: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/27920870/pyle-disease-metaphyseal-dysplasia-presenting-in-two-adult-sisters
#2
Diego Ximenes Soares, Amália Mapurunga Almeida, André Rodrigues Façanha Barreto, Ilze Jucá Alencar E Silva, José Daniel Vieira de Castro, Francisco José Magalhães Pinto, Daniel Aguiar Dias, Lindenberg Barbosa Aguiar
Pyle's disease is an extremely rare skeletal disorder characterized by a benign course and an autosomal recessive genetic pattern of inheritance. Its causal mutation is still unknown. In the medical literature, fewer than 30 cases have been described to date. We report the case of two female siblings, daughters of consanguineous parents, referred to the radiology department complaining of genu valgum. Laboratory tests showed no other relevant findings. Conventional radiography plain films revealed Erlenmeyer flask deformity in bilateral femorotibial metaphyses, metaphyseal flaring of long bones, and mild sclerosis of the skull base...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920201/the-streptococcus-gordonii-adhesin-csha-binds-host-fibronectin-via-a-catch-clamp-mechanism
#3
Catherine R Back, Maryta N Sztukowska, Marisa Till, Richard J Lamont, Howard F Jenkinson, Angela H Nobbs, Paul R Race
Adherence of bacteria to biotic or abiotic surfaces is a prerequisite for host colonization and represents an important step in microbial pathogenicity. This attachment is facilitated by bacterial adhesins at the cell surface. Due to their size and often elaborate multi-domain architectures, these polypeptides represent challenging targets for detailed structural and functional characterization. The multifunctional fibrillar adhesin CshA, which mediates binding to both host molecules and other microorganisms, is an important determinant of colonisation by Streptococcus gordonii, an oral commensal and opportunistic pathogen of animals and humans...
December 5, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27918876/awareness-of-identity-alteration-and-diagnostic-preference-between-borderline-personality-disorder-and-dissociative-disorders
#4
Vedat Sar, Firdevs Alioğlu, Gamze Akyuz, Emre Tayakısı, Ezgi F Öğülmüş, Doğuş Sönmez
AIM: This study inquires into identity alteration among college students and its relationship to borderline personality disorder (BPD) and/or dissociative disorders (DDs). METHODS: Steinberg Identity Alteration Questionnaire (SIAQ), Childhood Trauma Questionnaire (CTQ), and self-report screening tool of the BPD section of the Structured Clinical Interview for DSM-IV (SCID-BPD) were administered to 1301 college students. Participants who fit the diagnostic criteria of BPD (n = 80) according to the clinician-administered SCID-BPD and 111 non-BPD controls were evaluated using the Structured Clinical Interview for DSM-IV DDs (SCID-D) by two psychiatrists blind to the group membership and scale scores...
December 5, 2016: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/27916750/-pathophysiology-of-ataxia-in-fisher-syndrome
#5
Satoshi Kuwabara
Fisher syndrome is regarded as a peculiar inflammatory neuropathy associated with ophthalmoplegia, ataxia, and areflexia. The disorder is associated with preceding infection, cerebrospinal fluid albumino-cytological dissociation, and spontaneous recovery, and regarded as a variant of Guillain-Barré syndrome. The discovery of anti-GQ1b IgG antibodies led to dramatic advances in understanding the pathophysiology of Fisher syndrome. The lesions in Fisher syndrome are determined by expression of ganglioside GQ1b in the human nervous system...
December 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27914507/psychiatric-psychological-injury-and-law-introduction
#6
EDITORIAL
Gerald Young
This special issue on psychiatric/psychological injury and law covers major developments in the field, and illustrates the complexities for mental health professionals in dealing with psychiatric/psychological injuries in court. The articles vary in the range of topics covered, and include ones on posttraumatic stress disorder, other trauma reactions, dissociation, disability, pain, and traumatic brain injury, in particular but also new areas, such as the effects of early penile injury. Work in the area of psychiatric/psychological injury and law needs to be scientifically-informed, comprehensive, and impartial, and the series of articles to follow will help workers in the area meet this standard...
November 2016: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/27914166/trauma-related-dissociation-psychological-features-and-psychophysiological-responses-to-script-driven-imagery-in-borderline-personality-disorder
#7
Dana Bichescu-Burian, Jürgen Steyer, Tilman Steinert, Benjamin Grieb, Stefan Tschöke
Defense reactions to threatening situations are vital adaptations to stress that protect organisms from injury and ensure survival. We retrospectively investigated the role of peritraumatic dissociation (PD) in the occurrence of severe psychopathology and dissociative patterns of reactions in borderline personality disorder (BPD). We recruited 28 patients with a clinical diagnosis of BPD and 15 healthy controls. The BPD group was divided according to the level of PD (low vs. high): BPD and PD (n = 15) and BPD only (n = 13)...
December 3, 2016: Psychophysiology
https://www.readbyqxmd.com/read/27913716/single-and-multiple-clinical-syndromes-in-incarcerated-offenders-associations-with-dissociative-experiences-and-emotionality
#8
Carlo Garofalo, Patrizia Velotti, Cristina Crocamo, Giuseppe Carrà
The present study examined the prevalence and correlates of clinical syndromes in a large group (N = 438) of incarcerated violent offenders, looking at differences between inmates with one and those with more than one clinical syndromes. More than a half of the sample (57%) reported clinically relevant symptoms for at least one clinical syndrome (n = 252), and the majority of them (38%) reported more syndromes in comorbidity (n = 169). Increased severity of clinical conditions (none, one, more than one syndrome) corresponded with significantly greater levels of personality disorder traits, psychological symptoms, dissociation, and negative emotionality, with large effect sizes...
December 1, 2016: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/27906103/progressive-impairment-of-cav1-1-function-in-the-skeletal-muscle-of-mice-expressing-a-mutant-type-1-cu-zn-superoxide-dismutase-g93a-linked-to-amyotrophic-lateral-sclerosis
#9
Donald Beqollari, Christin F Romberg, Gabriella Dobrowolny, Martina Martini, Andrew A Voss, Antonio Musarò, Roger A Bannister
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that is typically fatal within 3-5 years of diagnosis. While motoneuron death is the defining characteristic of ALS, the events that underlie its pathology are not restricted to the nervous system. In this regard, ALS muscle atrophies and weakens significantly before presentation of neurological symptoms. Since the skeletal muscle L-type Ca(2+) channel (CaV1.1) is a key regulator of both mass and force, we investigated whether CaV1...
June 23, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27889491/pramipexole-enhances-disadvantageous-decision-making-lack-of-relation-to-changes-in-phasic-dopamine-release
#10
Romina Pes, Sean C Godar, Andrew T Fox, Lauren M Burgeno, Hunter J Strathman, David P Jarmolowicz, Paola Devoto, Beth Levant, Paul E Phillips, Stephen C Fowler, Marco Bortolato
Pramipexole (PPX) is a high-affinity D2-like dopamine receptor agonist, used in the treatment of Parkinson's disease (PD) and restless leg syndrome. Recent evidence indicates that PPX increases the risk of problem gambling and impulse-control disorders in vulnerable patients. Although the molecular bases of these complications remain unclear, several authors have theorized that PPX may increase risk propensity by activating presynaptic dopamine receptors in the mesolimbic system, resulting in the reduction of dopamine release in the nucleus accumbens (NAcc)...
November 23, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27882998/dopamine-and-opioid-neurotransmission-in-behavioral-addictions-a-comparative-pet-study-in-pathological-gambling-and-binge-eating
#11
Joonas Majuri, Juho Joutsa, Jarkko Johansson, Valerie Voon, Kati Alakurtti, Riitta Parkkola, Tuuli Lahti, Hannu Alho, Jussi Hirvonen, Eveliina Arponen, Sarita Forsback, Valtteri Kaasinen
Although behavioral addictions share many clinical features with drug addictions, they show strikingly large variation in their behavioral phenotypes (such as in uncontrollable gambling or eating). Neurotransmitter function in behavioral addictions is poorly understood but has important implications in understanding its relationship with substance use disorders and underlying mechanisms of therapeutic efficacy. Here, we compare opioid and dopamine function between two behavioral addiction phenotypes: pathological gambling (PG) and binge eating disorder (BED)...
November 24, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27878907/from-childhood-trauma-to-self-harm-an-investigation-of-theoretical-pathways-among-female-prisoners
#12
Ruth Howard, Thanos Karatzias, Kevin Power, Adam Mahoney
BACKGROUND: Despite empirical evidence suggesting complex associations between childhood trauma and self-harm, there is a dearth of research investigating this association in the female prison population. The current study explored pathways to self-harm following childhood trauma, by investigating the mediating roles of Post-traumatic Stress Disorder (PTSD) symptoms, emotion regulation and dissociation, in this relationship, within a sample of 89 female prisoners. METHODS: Cross-sectional, interview-format, questionnaire study within a female prison population...
November 22, 2016: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/27878599/-acoustic-reflexes-of-children-with-and-without-central-auditory-processing-disorders
#13
S Kunze, A Nickisch, H von Voss, V Mall
BACKGROUND: According to international standards, determination of acoustic reflex thresholds (ART) is one of the established objective measurements in the diagnostic workup of central auditory processing disorders (CAPD). However, there is still no evidence for the significance of ART in CAPD diagnosis. PATIENTS AND METHODS: This study tested 57 children with proven CAPD and 50 healthy children (control group) with regard to group differences in mean ART (sine tones or bandpass-filtered noise)...
November 23, 2016: HNO
https://www.readbyqxmd.com/read/27876453/-i-can-t-tell-whether-it-s-my-hand-a-pilot-study-of-the-neurophenomenology-of-body-representation-during-the-rubber-hand-illusion-in-trauma-related-disorders
#14
Daniela Rabellino, Sherain Harricharan, Paul A Frewen, Dalila Burin, Margaret C McKinnon, Ruth A Lanius
BACKGROUND: Early traumatic experiences are thought to be causal factors in the development of trauma-related dissociative experiences, including depersonalization and derealization. The rubber hand illusion (RHI), a well-known paradigm that measures multi-sensorial integration of a rubber hand into one's own body representation, has been used to investigate alterations in the experience of body ownership and of body representation. Critically, however, it has never been studied in individuals with trauma-related disorders...
2016: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/27873541/the-relationship-between-suppression-and-subsequent-intrusions-the-mediating-role-of-peritraumatic-dissociation-and-anxiety
#15
Cornelia Măirean, Ciprian Marius Ceobanu
BACKGROUND AND OBJECTIVES: Although previous studies showed that thought and emotion suppression represent risk factors for intrusions development, the mechanisms that explain these relations were less explored. This study aims to examine the relationships between thought and emotion suppression and the symptoms of intrusion following the exposure to a trauma-related event. Moreover, we explored if these relationships would be mediated by peritraumatic state dissociation and state anxiety...
November 22, 2016: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/27871792/dual-inhibition-of-bace1-and-a%C3%AE-aggregation-by-%C3%AE-ecdysone-application-of-a-phytoecdysteroid-scaffold-in-alzheimer-s-disease-therapeutics
#16
Sandipan Chakraborty, Soumalee Basu
Current medications for the complex neurological disorder, Alzheimer's disease (AD), can neither stop disease progression nor revert back disease pathogenesis. The present study demonstrates the applicability of a phytoecdysteroid, β-ecdysone, as a multi-potent agent in AD therapeutics. β-ecdysone strongly binds to the active site cavity of BACE1 with calculated dissociation constant of 1.75±0.1μM. Steady-state and time-resolved fluorescence spectroscopy reveal that binding of β-ecdysone induces conformational transition of the protein from open to closed form thereby blocking substrate binding...
November 18, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27869465/association-of-peritraumatic-dissociation-with-symptoms-of-depression-and-posttraumatic-stress-disorder
#17
Erin C McCanlies, Khachatur Sarkisian, Michael E Andrew, Cecil M Burchfiel, John M Violanti
Aim: In this study, we evaluated whether peritraumatic dissociation (PD) was associated with symptoms of depression and posttraumatic stress disorder (PTSD), and whether this association was modified by trauma prior to police work. Method: Symptoms of depression, PTSD, peritraumatic dissociative experience (PDE), and trauma prior to police work were measured using the Center for Epidemiologic Studies Depression scale, PTSD Checklist-Civilian, PDE questionnaire, and the Brief Trauma questionnaire, respectively, in 328 police officers...
November 21, 2016: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27861556/antioxidant-properties-of-kynurenines-density-functional-theory-calculations
#18
Aleksandr V Zhuravlev, Gennady A Zakharov, Boris F Shchegolev, Elena V Savvateeva-Popova
Kynurenines, the main products of tryptophan catabolism, possess both prooxidant and anioxidant effects. Having multiple neuroactive properties, kynurenines are implicated in the development of neurological and cognitive disorders, such as Alzheimer's, Parkinson's, and Huntington's diseases. Autoxidation of 3-hydroxykynurenine (3HOK) and its derivatives, 3-hydroxyanthranilic acid (3HAA) and xanthommatin (XAN), leads to the hyperproduction of reactive oxygen species (ROS) which damage cell structures. At the same time, 3HOK and 3HAA have been shown to be powerful ROS scavengers...
November 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27857212/gr-independent-down-modulation-on-gm-csf-bone-marrow-derived-dendritic-cells-by-the-selective-glucocorticoid-receptor-modulator-compound-a
#19
Andres E Barcala Tabarrozzi, Luz Andreone, Julie Deckers, Carla N Castro, María L Gimeno, Laura Ariolfo, Paula M Berguer, María Antunica-Noguerol, Ana C Liberman, Sabine Vettorazzi, Jan P Tuckermann, Karolien De Bosscher, Marcelo J Perone
Dendritic cells (DC) initiate the adaptive immune response. Glucocorticoids (GCs) down-modulate the function of DC. Compound A (CpdA, (2-(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride) is a plant-derived GR-ligand with marked dissociative properties. We investigated the effects of CpdA on in vitro generated GM-CSF-conditioned bone marrow-derived DC (BMDC). CpdA-exposed BMDC exhibited low expression of cell-surface molecules and diminution of the release of proinflammatory cytokines upon LPS stimulation; processes associated with BMDC maturation and activation...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27855738/sexsomnia-a-specialized-non-rem-parasomnia
#20
Anne-Laure Dubessy, Smaranda Leu-Semenescu, Valérie Attali, Jean-Baptiste Maranci, Isabelle Arnulf
OBJECTIVE: To describe patients with sexsomnia and to contrast their clinical and sleep measures with those of healthy controls and sleepwalkers. METHODS: Subjects referred for sexsomnia and for sleepwalking/night terror were interviewed, completed the Paris Arousal Disorder Severity Scale (PADSS) and were monitored one to two nights with video-polysomnography. RESULTS: Seventeen patients (70.6% male, aged 17 to 76 years) had sexsomnia, with amnestic fondling of the bed partner (n=11), complete sexual intercourse (n=8), masturbation (n=8) and spontaneous orgasm (n=1)...
October 28, 2016: Sleep
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