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Angiofibroma juvenil

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https://www.readbyqxmd.com/read/27833886/a-drastic-aftermath-of-embolisation-in-juvenile-nasopharyngeal-angiofibroma
#1
Narayanan Janakiram, Shilpee Bhatia Sharma, Vidya Bhargavan Panicker, C V Srinivas
The role of preoperative embolization in alleviating intra operative haemorrhage in small to medium sized JNA is dubious. We report an unusual case of JNA who developed cerebral edema, hemiplegia and aphasia following glue embolisation and underwent frontotemporal craniectomy. This drastic aftermath of embolisation challenges the safety of preoperative embolisation in such lesions.
December 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27752379/juvenile-nasopharyngeal-angiofibroma-presenting-with-acute-airway-obstruction
#2
Chikoti Wheat, Ryan J Bickley, Erik Cohen, Danya Wenzler, Nancy Hunter, Donna Astiz
We describe a case of a 24-year-old male presenting urgently with a juvenile nasopharyngeal angiofibroma (JNA) with difficulty breathing, inability to swallow, and respiratory distress following throat swelling. The swelling was reduced with administration of dexamethasone and the JNA was surgically resected within 48 hours. This presentation was atypical given the acuity of presentation and the patient's older age.
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27601836/juvenile-nasopharyngeal-angiofibroma
#3
Jashika Adil Shroff Makhasana, Meena A Kulkarni, Suhas Vaze, Adil Sarosh Shroff
Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive neoplasm and shows a propensity for destructive local spread often extending to the base of the skull and into the cranium. Clinically, however, it is obscure with painless, progressive unilateral nasal obstruction being the common presenting symptom with or without epistaxis and rhinorrhea. Diagnosis of JNA is made by complete history, clinical examination, radiography, nasal endoscopy and by using specialized imaging techniques such as arteriography, computer tomography and magnetic resonance imaging...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27577998/current-molecular-profile-of-juvenile-nasopharyngeal-angiofibroma-first-comprehensive-study-from-india
#4
Praveen Pandey, Anupam Mishra, Ashoak Mani Tripathi, Veerendra Verma, Ritu Trivedi, Hitendra Prakash Singh, Sunil Kumar, Brijesh Patel, Vinay Singh, Shivani Pandey, Amita Pandey, Subhash Chandra Mishra
OBJECTIVE: An attempt is made to analyze the molecular behavior of juvenile nasopharyngeal angiofibroma (JNA). STUDY DESIGN: Case Series METHODS: Quantification of mRNAs expression was undertaken through real-time polymerase chain reaction in JNA (9-24) samples for VEGF-A, basic fibroblast growth factor (b-FGF), platelet-derived growth factor PDGF-A, KIT proto-oncogene receptor tyrosine kinase (c-Kit), Avian myelomatosis viral oncogene homolog (c-Myc), Harvey rat sarcoma viral oncogene homolog (H-Ras), tumor suppressor gene TP53, and androgen receptor and interleukin 6 (IL-6)...
August 31, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27572281/current-status-and-clinical-association-of-beta-catenin-with-juvenile-nasopharyngeal-angiofibroma
#5
A Mishra, V Singh, V Verma, S Pandey, R Trivedi, H P Singh, S Kumar, R C Dwivedi, S C Mishra
OBJECTIVE: A possible role of the APC/beta-catenin pathway in the pathogenesis of sporadic juvenile nasopharyngeal angiofibroma has been suggested. This paper presents its current status and clinical association in our patients. METHOD: A prospective observational study was conducted at King George Medical University and Central Drug Research Institute, in Lucknow, India. Western blot analysis was undertaken in 16 cases to examine beta-catenin expression. The clinical details were recorded along with follow up observations, to determine associations...
August 30, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27542804/emergency-department-care-of-childhood-epistaxis
#6
E Béquignon, N Teissier, A Gauthier, L Brugel, H De Kermadec, A Coste, V Prulière-Escabasse
OBJECTIVE: The aim of this review is to determine an efficient and safe primary strategy care for paediatric epistaxis. DATA SOURCES: We searched PubMed and Cochrane databases for studies referenced with key words 'epistaxis AND childhood'. This search yielded 32 research articles about primary care in childhood epistaxis (from 1989 to 2015). Bibliographic references found in these articles were also examined to identify pertinent literature. We compared our results to the specific management of adult epistaxis classically described in the literature...
August 19, 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27532520/rare-infratentorial-and-supratentorial-localization-of-juvenile-angiofibroma-a-case-report
#7
Ivan Pašalić, Ines Trninić, Jakob Nemir, Hrvoje Jednačak, Kamelija Žarković, Goran Mrak
Angiofibromas are rare tumors of the head and neck that mostly occur in the sphenopalatine region. We present a case of angiofibroma in a young male patient with an unusual and extremely rare localization, which to our knowledge has not been described before. It was situated in the tentorium and spread to the supratentorial and infratentorial regions. The patient initially presented with symptoms of increased intracranial pressure. After a diagnostic evaluation was done, the whole tumor was successfully removed using the supratentorial and infratentorial approach and the microsurgical technique...
2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27508124/endoscopic-excision-of-non-embolized-juvenile-nasopharyngeal-angiofibroma-our-technique
#8
Trichy Narayanan Janakiram, Shilpee Bhatia Sharma, Vidya Bhargavan Panicker
To approach Juvenile nasopharyngeal angiofibroma extending to the sphenoid sinus, pterygoid wedge and minimal involvement of the pterygopalatine fossa (Radkowski Stage 2 A) with an endoscopic technique without embolization with no recurrence and minimal morbidity and mortality. This is a retrospective, descriptive study based on the medical records of 15 patients with histologically confirmed JNA who underwent endoscopic binostril four handed endoscopic excision in our centre without embolisation between 2010 and 2015...
September 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27436213/asystole-during-onyx-embolization-of-a-pediatric-arteriovenous-malformation-a-severe-case-of-the-trigeminocardiac-reflex
#9
Kasra Khatibi, Omar Choudhri, Ian D Connolly, Ryan A McTaggart, Huy M Do
Trigeminal-cardiac reflex (TCR) from stimulation of sensory branches of trigeminal nerve can lead to hemodynamic instability. This phenomenon has been described during ophthalmologic, craniofacial, and skull base surgeries. TCR has been rarely reported with endovascular onyx embolization of dural Arteriovenous fistulas (DAVF). We report a case of TCR during endovascular Onyx embolization of an arteriovenous malformation (AVM). A 16-year-old boy presented with a large cerebellar AVM with arterial feeders from external carotid artery and posterior cerebral artery branches...
July 16, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27421657/the-isolation-and-characterization-of-endothelial-cells-from-juvenile-nasopharyngeal-angiofibroma
#10
Jingjing Wang, Zhoufu Liu, Li Hu, Xicai Sun, Huapeng Yu, Huankang Zhang, Chenhe Yang, Quan Liu, Dehui Wang
No abstract text is available yet for this article.
September 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27340627/juvenile-nasopharyngeal-angiofibroma-a-rise-in-incidence
#11
Pradip Kumar Tiwari, Pinpo Teron, Nabajyoti Saikia, H P Saikia, U T Bhuyan, Debajit Das
Juvenile nasopharyngeal angiofibroma is a very rare, highly vascular, uncapsulated and locally invasive tumor. Recently a changing trend has been seen in its epidemiology, pathogenesis, diagnosis, medical management, pre-operative care, surgical management and post-operative care including radiotherapy. Study the changing trend basically in the north-eastern region of south-east Asia and its prospects. Retrospective study of patients presenting with JNA between the study period of 6 months (October 2014-March 2015) in the, Department of Otolaryngology and Head and Neck Surgery, Assam Medical College, Dibrugarh, Assam, India...
June 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27289235/association-between-vascular-supply-stage-and-tumour-size-of-juvenile-nasopharyngeal-angiofibroma
#12
Raghav Mehan, V Rupa, Vijay Kumar Lukka, Munawar Ahmed, Vinu Moses, N K Shyam Kumar
Juvenile nasopharyngeal angiofibroma (JNA) is a highly vascular tumour seen in adolescent males. To study the vascular pattern of these tumours, we retrospectively reviewed the records of patients with JNA who underwent preoperative angiography. Most (82.2 %) of the 45 patients assessed were Radkowski stage III with a mean size of 5.29 cm. There was a significant association between tumour stage and size (p = 0.029). Ten different vessels were seen to supply these tumours. All tumours had primary supply from the distal third of the ipsilateral internal maxillary artery (IMA)...
June 11, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27267025/managing-vascular-tumors-open-approaches
#13
REVIEW
Cecelia E Schmalbach, Christine Gourin
The most common vascular tumors encountered by the otolaryngologist are rare chromaffin cell tumors termed paragangliomas. Within the head and neck region, they commonly arise from the carotid body, vagus nerve (glomus vagale), and jugular vein (glomus jugulare). Other vascular head and neck tumors include sinonasal malignancies, because of proximity to or involvement of the pterygoid plexus as well as the rich vascularity of the sinonasal mucosa; juvenile nasopharyngeal angiofibroma, a vascular tumor of male adolescents; unusual vascular tumors such as hemangiopericytoma; and metastatic renal cell cancer, which has a proclivity for an unusually rich blood supply...
June 2016: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/27178522/time-trends-in-recurrence-of-juvenile-nasopharyngeal-angiofibroma-experience-of-the-past-4-decades
#14
Anupam Mishra, Subhash Chandra Mishra
BACKGROUND: An analysis of time distribution of juvenile nasopharyngeal angiofibroma (JNA) from the last 4 decades is presented. METHODS: Sixty recurrences were analyzed as per actuarial survival. SPSS software was used to generate Kaplan-Meier (KM) curves and time distributions were compared by Log-rank, Breslow and Tarone-Ware test. RESULTS: The overall recurrence rate was 17.59%. Majority underwent open transpalatal approach(es) without embolization...
May 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27164528/juvenile-nasopharyngeal-angiofibroma
#15
Satvinder S Bakshi, Sumita Bhattacharjee
A 9 year old male presented with nasal obstruction and recurrent, unprovoked epistaxis for 1 week. Imaging revealed a highly vascular mass in the nasopharynx. The feeding vessels were subsequently embolized and the mass was removed completely. Juvenile nasopharyngeal angiofibroma is a benign but locally invasive tumor accounting for about 0.05% of all head and neck tumors. Patients usually present with nasal obstruction and epistaxis. The tumor can however be extensive on presentation with intra orbital and intra cranial extension...
August 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27157983/human-papilloma-virus-in-juvenile-nasopharyngeal-angiofibroma-possible-recent-trend
#16
Anupam Mishra, Monica Sachadeva, Ankita Jain, Nimisha Mishra Shukla, Amita Pandey
BACKGROUND: Juvenile nasopharyngeal angiofibroma (JNA) has witnessed a four-fold increase in the incidence at our facility in the current decade as compared to the 1980s. With high global incidence of human pappilloma virus (HPV) related oropharyngeal cancer in India, we hypothesize its implication in JNA as it has not yet been reported. METHODS: Clinico-Surgical variables of 6 patients of JNA were included for correlation and their tissue samples were subjected to western blotting (WB), polymerase chain reaction and immunoflorescence to demonstrate a definite association with HPV...
July 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27107599/-a-juvenile-nasopharyngeal-angiofibroma-our-10-year-experience-in-a-tertiary-centre
#17
Bayram Şahin, Şenol Çomoğlu, Said Sönmez, Beldan Polat, Kemal Değer
OBJECTIVES: This study aims to evaluate the demographic characteristics, tumor stage, surgical treatment and recurrence rate among patients operated with a juvenile nasopharyngeal angiofibroma. PATIENTS AND METHODS: This retrospective study included 45 patients (44 males, 1 female; mean age 21 years, range 9 to 55 years) who underwent surgery at Istanbul University, Istanbul Medical Faculty, Department of Otorhinolaryngology clinic between March 2006 and July 2015...
May 2016: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
https://www.readbyqxmd.com/read/27066789/avoiding-allogenic-blood-transfusions-in-endoscopic-angiofibroma-surgery
#18
Hisham Wasl, Jessica McGuire, Darlene Lubbe
BACKGROUND: Surgical approaches for many tumours are often limited by blood loss, exposure and risk to vital anatomical structures. Therefore, the standard of care for certain skull base tumours has become endoscopic transnasal resection. Other surgical disciplines often use cell salvage techniques, but review of the otolaryngology literature revealed very few case reports. This study investigated the value and safety of salvage-type autologous blood transfusion during the endoscopic resection of juvenile nasopharyngeal angiofibromas (JNA)...
2016: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27059153/expanded-endoscopic-endonasal-surgery-for-advanced-stage-juvenile-angiofibromas-a-retrospective-multi-center-study
#19
C Langdon, P Herman, B Verillaud, R L Carrau, D Prevedello, P Nicolai, A Schreiber, G Padoan, P Castelnuovo, M Bernal-Sprekelsen
OBJECTIVES: Endoscopic resection has become an established surgical option for most juvenile nasopharyngeal angiofibromas (JNA). However, surgical management of JNA with intracranial extension remains challenging. This retrospective multicenter study reviews a series of patients with advanced stage JNA treated via endonasal/endoscopic approach. METHODS: The experience of five academic tertiary or quaternary care ORL-HNS Departments were included. Medical records of all patients operated for JNA staged as Radkowski stage IIIA or IIIB were reviewed...
September 2016: Rhinology
https://www.readbyqxmd.com/read/26971784/-68-ga-dotatate-pet-in-juvenile-angiofibroma
#20
Zuzanna Gronkiewicz, Wojciech Kukwa, Leszek Krolicki, Agata Cyran-Chlebicka, Dariusz Pawlak, Czeslaw Stankiewicz, Antoni Krzeski, Barbara Górnicka, Dominika Wolosz, Jolanta Kunikowska
BACKGROUND: As somatostatin receptors (SSTRs) may be overexpressed in rapidly growing vessels, the aim of this study was the analysis of in vivo and in vitro SSTR2A expression in juvenile angiofibroma (JA). MATERIAL & METHODS: A group of six male adolescents with a diagnosis of primary, recurrent/residual JA was enrolled in the study. All patients underwent (68)Ga-DOTATATE PET/computed tomography (CT) followed by immunohistochemical staining for SSTR expression...
June 2016: Future Oncology
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