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Angiofibroma juvenil

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https://www.readbyqxmd.com/read/29143693/a-rare-case-of-extra-nasopharyngeal-angiofibroma-of-the-septum-in-a-female-child
#1
G B Singh, S Shukla, P Kumari, I Shukla
BACKGROUND: Extra-nasopharyngeal angiofibroma is a rare but distinct clinical entity, different from juvenile angiofibroma. METHODS: This clinical record elucidates the only case of extra-nasopharyngeal angiofibroma arising from the septum in a female child, who presented with epistaxis. RESULTS: The histopathological diagnosis was confirmed by immunohistochemistry, and the case was managed surgically with no recurrence. CONCLUSION: In a female paediatric patient presenting with epistaxis, extra-nasopharyngeal angiofibroma (of the inferior turbinate) is a rare albeit important differential diagnosis, as it challenges the hormonal theory of angiofibroma aetiopathogenesis...
November 16, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29130560/patterns-of-vascularization-and-surgical-morbidity-in-juvenile-nasopharyngeal-angiofibroma-a-case-series-systematic-review-and-meta-analysis
#2
Jonathan B Overdevest, Matthew R Amans, Peter Zaki, Steven D Pletcher, Ivan H El-Sayed
BACKGROUND: Vascular patterns of juvenile nasopharyngeal angiofibroma (JNA) are poorly defined. We performed both institutional and systematic literature reviews to characterize the relationship between arterial supply patterns of JNA with intraoperative blood loss and tumor recurrence. METHODS: A retrospective review of 26 patients with JNA treated at our institution from 1995 to 2015 with available angiograms, and systematic reviews and meta-analyses of 828 JNA cases undergoing angiographic embolization published between 1995 and 2015 were completed per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
November 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/29114314/endoscopic-three-surgeon-six-handed-transorbital-transnasal-technique-for-excision-of-juvenile-nasopharygeal-angiofibroma-new-frontier-explored
#3
Trichy Narayanan Janakiram, Palak Parekh, Hanish Haneefa, Sivaswamy Karthik Prasad
Endoscopic endonasal transorbital approach has been described for the removal of orbital lesions located anteromedially in temporal fossa. The same has been observed to be a versatile approach to the anterior and middle cranial fossa only in laboratory studies. This is the first clinical report of combined transorbital transnasal endoscopic approach to the cavernous sinus, superior orbital fissure, and middle cranial fossa in a case of recurrent nasopharyngeal angiofibroma using the three-surgeon six-handed technique...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29076693/angiofibroma-in-a-50-year-old-patient
#4
Syed Shahmeer Raza, Syed Muhammad Owais, Salman Zahid, Ihtisham Ul Haq, Haris Manan, Syeda Fizza Qasim, Farhan Ullah, Asfandiar Shahrukh Hijazi, Osamah Riaz Khan
Juvenile Angiofibroma (JNA) is a benign tumour that tends to bleed and occur in the nasopharynx with most cases occurring in pre-pubertal and adolescent males 10-20 years. We present the case of a 50-year-old male shopkeeper who consulted the ENT out patients' department (OPD) of Khyber Teaching Hospital (KTH) with the chief complaint of right sided nasal obstruction for the last 2.5 months which was associated with two episodes of epistaxis and diplopia which started 2 months back. He complained of right sided frontal and periorbital pain for the last 15 days...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29069259/endoscopic-endonasal-approach-for-mass-resection-of-the-pterygopalatine-fossa
#5
Jan Plzák, Vít Kratochvil, Adam Kešner, Pavol Šurda, Aleš Vlasák, Eduard Zvěřina
OBJECTIVES: Access to the pterygopalatine fossa is very difficult due to its complex anatomy. Therefore, an open approach is traditionally used, but morbidity is unavoidable. To overcome this problem, an endoscopic endonasal approach was developed as a minimally invasive procedure. The surgical aim of the present study was to evaluate the utility of the endoscopic endonasal approach for the management of both benign and malignant tumors of the pterygopalatine fossa. METHOD: We report our experience with the endoscopic endonasal approach for the management of both benign and malignant tumors and summarize recent recommendations...
October 2017: Clinics
https://www.readbyqxmd.com/read/29019747/masses-of-the-nose-nasal-cavity-and-nasopharynx-in-children
#6
Diana P Rodriguez, Emily S Orscheln, Bernadette L Koch
A wide range of masses develop in the nose, nasal cavity, and nasopharynx in children. These lesions may arise from the nasal ala or other structures of the nose, including the mucosa covering any surface of the nasal cavity, the cartilaginous or osseous portion of the nasal septum, the nasal turbinates, and the nasal bones. Lesions may also arise from the nasopharynx or adjacent structures and involve the nose by way of direct extension. The causes of nasal masses in children include congenital and developmental disorders such as congenital nasolacrimal duct mucocele, dermoid cyst, cephalocele, and nasal neuroglial heterotopia; inflammatory and infectious processes such as mucocele, polyp, and pyogenic granuloma; benign neoplasms such as infantile hemangioma and juvenile nasopharyngeal angiofibroma; malignant lesions such as rhabdomyosarcoma and nasopharyngeal carcinoma; and masses related to prior trauma such as septal hematoma...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28929055/the-four-port-bradoo-technique-an-alternative-to-the-modified-endoscopic-denker-s-approach-for-giant-jna
#7
Renuka Bradoo, Anagha Joshi, Kshtij Shah, Tejal Patel, Tanvi Lohiya
The aim of this study is to emphasise the importance of preserving the anterior facial skeleton in angiofibroma surgery and to introduce a new approach by which tumors with far lateral extensions can be operated upon successfully without disruption of the anterior facial skeleton. This is a prospective study conducted at a tertiary referral academic centre. Two patients with extensive juvenile nasopharyngeal angiofibroma with far lateral extensions were recruited and they underwent surgery between July and August 2016...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28885437/cellular-angiofibroma-of-the-nasopharynx
#8
Zülküf Burak Erdur, Haydar Murat Yener, Mehmet Yilmaz, Ayşegül Batioğlu Karaaltin, Hakki Caner Inan, Elvin Alaskarov, Emine Deniz Gozen
Angiofibroma is a common tumor of the nasopharynx region but cellular type is extremely rare in head and neck. A 13-year-old boy presented with frequent epistaxis and nasal obstruction persisting for 6 months. According to the clinical symptoms and imaging studies juvenile angiofibroma was suspected. Following angiographic embolization total excision of the lesion by midfacial degloving approach was performed. Histological examination revealed that the tumor consisted of staghorn blood vessels and irregular fibrous stroma...
November 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28845691/four-dimensional-ct-angiography-4d-cta-in-the-evaluation-of-juvenile-nasopharyngeal-angiofibromas-comparison-with-digital-subtraction-angiography-dsa-and-surgical-findings
#9
Zebin Xiao, Yingyan Zheng, Jian Li, Dehua Chen, Fang Liu, Dairong Cao
OBJECTIVES: To explore the value of four-dimensional CT angiography (4D-CTA) in the preoperative evaluation of juvenile nasopharyngeal angiofibromas (JNAs) using 320-row volume CT. METHODS: 4D-CTA and DSA data of 18 patients with histopathologically proven JNAs were retrospectively reviewed. The location, extent, feeding vessels and stage of JNAs were assessed by two radiologists independently and blindly. The agreements between both reviewers and between 4D-CTA and surgical findings for assessing the above indicators were analysed, respectively...
October 10, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28781841/perioperative-airway-management-of-a-16-year-old-boy-with-progressive-airway-obstruction-due-to-juvenile-nasopharyngeal-angiofibroma
#10
Kei Kamiyama, Maiko Satomoto, Kotaro Minami, Yukiko Baba, Koshi Makita
Juvenile nasopharyngeal angiofibroma (JNA) involves difficult anesthetic management because of the risk of massive bleeding, while airway management is rarely a problem in JNA. This report presents an unusual case of JNA causing airway obstruction.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28765177/massive-juvenile-nasopharyngeal-angiofibroma-ode-to-the-open-surgical-approach
#11
Ravi Meher, Nikhil Arora, Eishaan Kamta Bhargava, Ruchika Juneja
The management of juvenile nasopharyngeal angiofibroma has undergone a significant evolution, with more surgeons moving towards the minimal invasive endoscopic approaches. Although considered the standard of care by most, an endoscopic approach may not be sufficient for extensive tumours, as exemplified by the current case of a young man presenting with the largest juvenile nasopharyngeal angiofibroma described in English literature until the present that was eventually excised via an anterior external approach...
August 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28740564/can-diffusion-weighted-imaging-aid-in-differentiating-benign-from-malignant-sinonasal-masses-a-useful-adjunct
#12
Abanti Das, Ashu S Bhalla, Raju Sharma, Atin Kumar, Alok Thakar, Sreenivas M Vishnubhatla, Mehar C Sharma, Suresh C Sharma
BACKGROUND: To evaluate the role of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) values at 3 Tesla in characterizing sinonasal masses. MATERIAL/METHODS: After ethical clearance, 79 treatment naive patients with head and neck masses underwent magnetic resonance imaging (MRI), including DWI at 3 Tesla using the following b values - 0, 500 and 1000 s/mm(2). Thirty-one patients were found to have sinonasal tumours and were subsequently analysed...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28707818/inhibition-of-fibroblast-growth-factor-receptor-with-azd4547-mitigates-juvenile-nasopharyngeal-angiofibroma
#13
Tran Le, Jacob New, Joel W Jones, Shireen Usman, Sreeya Yalamanchali, Ossama Tawfik, Larry Hoover, Dan E Bruegger, Sufi Mary Thomas
BACKGROUND: Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor that presents in adolescent males. Although surgical excision is the mainstay of treatment, recurrences complicate treatment. There is a need to develop less invasive approaches for management. JNA tumors are composed of fibroblasts and vascular endothelial cells. We identified fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor (VEGF) expression in JNA-derived fibroblasts. FGFR influences fibroblast proliferation and VEGF is necessary for angiogenesis...
October 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28683841/variable-expression-of-molecular-markers-in-juvenile-nasopharyngeal-angiofibroma
#14
REVIEW
A Mishra, A Pandey, S C Mishra
BACKGROUND: Molecular categorisation may explain the wide variation in the clinical characteristics of juvenile nasopharyngeal angiofibroma. METHODS: Variations in molecular markers in juvenile nasopharyngeal angiofibroma in an Indian population were investigated and compared with global reports. RESULTS: Variable molecular marker expression was demonstrated at the regional and global levels. A wide variation in molecular characteristics is evident...
September 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28632604/reassessing-the-anatomic-origin-of-the-juvenile-nasopharyngeal-angiofibroma
#15
Colin D McKnight, Hemant A Parmar, Kuanwong Watcharotone, Suresh K Mukherji
OBJECTIVE: A modern imaging review is necessary to further define the anatomic origin of the juvenile nasopharyngeal angiofibroma. METHODS: After institutional review board approval, a search from January 1998 to January 2013 yielded 33 male patients (aged 10-23 years) with pathologically proven juvenile nasopharyngeal angiofibroma lesions, as well as pretreatment computed tomography/magnetic resonance imaging. Juvenile nasopharyngeal angiofibroma involvement was assessed in the following regions: sphenopalatine foramen, pterygopalatine fossa, vidian canal, nasopharynx, nasal cavity, sphenoid sinus, choana, pterygomaxillary fissure/masticator space, orbit, and sphenoid bone...
July 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28631685/-the-transperygoid-approach-to-the-removal-of-a-recurrent-juvenile-angiofibroma-at-the-base-of-the-skull-without-preoperative-embolization
#16
N S Grachev, I N Vorozhtsov
The authors report a clinical case of successful elimination of a recurrent juvenile angiofibroma at the base of the skull (JAFBS) with the application of the optical navigation system and a cold plasma scalpel in the absence of preoperative embolization. It has been demonstrated using the proposed transperygoid approach to the extirpation of the tumour that a recurrent juvenile angiofibroma at the base of the skull can be efficiently removed by means of a modern minimally invasive and at the same time radical surgical method...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28571176/juvenile-nasopharyngeal-angiofibroma-a-case-report
#17
Soubhagini Acharya, Choubarga Naik, Siddharth Panditray, Subha Soumya Dany
Juvenile nasopharyngeal angiofibroma is tumour almost exclusively seen in adolescent males, constituting less than 1% of all neoplasms in head and neck. They are benign and locally spreading and are highly vascular in nature and thus prove to be a surgical challenge because of its complex anatomical location. Here, we present a case report of a 18-year-old male presenting with a mass in his left nasal cavity, with recurrent epistaxis and nasal obstruction. Computed tomography imaging revealed a non-encapsulated lobulated heterogeneous mass lesion in the naso-pharynx and left posterior choana of the nasal cavity, extending to pterygopalatine and infratemporal fossa, masseter space of left side...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28540121/comprehensive-preoperative-staging-system-for-endoscopic-single-and-multicorridor-approaches-to-juvenile-nasal-angiofibromas
#18
Trichy N Janakiram, Shilpee B Sharma, Ekkehard Kasper, Onkar Deshmukh, Iype Cherian
BACKGROUND: Juvenile nasal angiofibromas (JNA) is a benign lesion with high vascularity and propensity of bone erosion leading to skull base invasion and intracranial extension. It is known to involve multiple compartments, which are often surgically difficult to access. With evolution in surgical expertise and technical innovations, endoscopic and endoscopic-assisted management has become the preferred choice of surgical management. Over the last four decades, various staging systems have been proposed, which are largely based on the extent of nasal angiofibroma...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28324181/trigeminocardiac-reflex-during-endoscopic-juvenile-nasopharyngeal-angiofibroma-surgery-an-appraisal
#19
Shilpee Bhatia Sharma, Trichy Narayanan Janakiram, Hina Baxi, Balamurugan Chinnasamy
Juvenile nasopharyngeal angiofibroma is a locally aggressive benign tumour which has propensity to erode the skull base. The tumour spreads along the pathways of least resistance and is in close proximity to the extracranial part of trigeminal nerve. Advancements in expanded approaches for endoscopic excision of tumours in infratemporal fossa and pterygopalatine fossa increase the vulnerability for the trigeminocardiac reflex. The manipulation of nerve and its branches during tumour dissection can lead to sensory stimulation and thus inciting the reflex...
July 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28286392/complications-of-midface-swing-for-management-of-juvenile-nasopharyngeal-angiofibroma
#20
Sanjay Roy Chowdhury, K Rajkumar, Tushar Deshmukh
INTRODUCTION: Access osteotomies provide direct exposure to inaccessible areas of the deep part of craniofacial skeleton for treating pathologies involving vital structures. The use of maxillary swing approach for gaining wide access to the nasopharynx, infratemporal fossa, parapharyngeal space, middle fossa of skull base. Though the maxillary swing requires transfacial incision for wide exposure but with careful handling the scar is minimum and this approach can be used in young people...
March 2017: Journal of Maxillofacial and Oral Surgery
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