keyword
https://read.qxmd.com/read/38546698/tocilizumab-administration-in-cytokine-release-syndrome-is-associated-with-hypofibrinogenemia-after-chimeric-antigen-receptor-t-cell-therapy-for-hematologic-malignancies
#1
JOURNAL ARTICLE
Markus Perl, Konstantin Herfeld, Dennis C Harrer, Matthias Höpting, Marina Schweiger, Ulrich Sterz, Leonard Knödler, Susanne Heimerl, Leo Hansmann, Wolfgang Herr, Hendrik Poeck, Daniel Wolff, Matthias Edinger, Christina Hart, Matthias A Fante
Chimeric antigen receptor (CAR-) T cell therapy causes serious side effects including cytokine release syndrome (CRS). CRS-related coagulopathy is associated with hypofibrinogenemia that is thus far considered the result of disseminated intravascular coagulation (DIC) and liver dysfunction. We investigated incidence and risk factors for hypofibrinogenemia in 41 consecutive adult patients with hematologic malignancies (median age 69 years, range 38-83 years) receiving CAR-T cell therapy between 01/2020 and 05/2023 at the University Medical Center Regensburg...
March 28, 2024: Haematologica
https://read.qxmd.com/read/38544873/a-rare-case-of-pantoea-bacterial-species-infection-a-new-mimicker-in-the-dermatology-office
#2
Benjamin Kahn, Shannon Hart, Heather Ivy Hensley, Marcus Goodman, Kristopher McKay
No abstract text is available yet for this article.
April 2024: JAAD Case Reports
https://read.qxmd.com/read/38541298/the-healthcare-and-societal-costs-of-familial-intellectual-disability
#3
JOURNAL ARTICLE
Deborah Schofield, Rupendra Shrestha, Owen Tan, Katherine Lim, Radhika Rajkumar, Sarah West, Jackie Boyle, Lucinda Murray, Melanie Leffler, Louise Christie, Morgan Rice, Natalie Hart, Jinjing Li, Robert Tanton, Tony Roscioli, Mike Field
Most of the studies on the cost of intellectual disability are limited to a healthcare perspective or cohorts composed of individuals where the etiology of the condition is a mixture of genetic and non-genetic factors. When used in policy development, these can impact the decisions made on the optimal allocation of resources. In our study, we have developed a static microsimulation model to estimate the healthcare, societal, and lifetime cost of individuals with familial intellectual disability, an inheritable form of the condition, to families and government...
March 4, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38539568/endoscopic-ultrasound-guided-needle-based-confocal-endomicroscopy-as-a-diagnostic-imaging-biomarker-for-intraductal-papillary-mucinous-neoplasms
#4
REVIEW
Shreyas Krishna, Ahmed Abdelbaki, Phil A Hart, Jorge D Machicado
Pancreatic cancer is on track to become the second leading cause of cancer-related deaths by 2030, yet there is a lack of accurate diagnostic tests for early detection. Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic cancer and are increasingly being detected. Despite the development and refinement of multiple guidelines, diagnosing high-grade dysplasia or cancer in IPMNs using clinical, radiologic, endosonographic, and cyst fluid features still falls short in terms of accuracy, leading to both under- and overtreatment...
March 21, 2024: Cancers
https://read.qxmd.com/read/38539033/a-comparison-of-two-statewide-datasets-to-understand-population-prevalence-of-substance-use-in-pregnancy-findings-and-considerations-for-policy-research
#5
JOURNAL ARTICLE
Margaret Lloyd Sieger, Jennifer C Morin, Lisa M Budris, Melissa Sienna, Sharon Ostfeld-Johns, Lou Hart, Christopher Morosky
Mental health conditions including substance use disorder are the leading cause of pregnancy-related deaths in the U.S. Unfortunately, fears of child protective services' involvement interfere with maternal self-disclosure of substance use in pregnancy. Seeking to identify more mothers with substance use disorder in pregnancy or at delivery, and responsive to changes to the federal Child Abuse Prevention and Treatment Act (CAPTA), Connecticut requires hospital personnel to submit a deidentified notification to CPS for all newborns with prenatal substance exposure...
March 27, 2024: Maternal and Child Health Journal
https://read.qxmd.com/read/38538867/a-shared-neoantigen-vaccine-combined-with-immune-checkpoint-blockade-for-advanced-metastatic-solid-tumors-phase-1-trial-interim-results
#6
JOURNAL ARTICLE
Amy R Rappaport, Chrisann Kyi, Monica Lane, Meghan G Hart, Melissa L Johnson, Brian S Henick, Chih-Yi Liao, Amit Mahipal, Ardaman Shergill, Alexander I Spira, Jonathan W Goldman, Ciaran D Scallan, Desiree Schenk, Christine D Palmer, Matthew J Davis, Sonia Kounlavouth, Lindsey Kemp, Aaron Yang, Yaojun John Li, Molly Likes, Annie Shen, Gregory R Boucher, Milana Egorova, Robert L Veres, J Aaron Espinosa, Jason R Jaroslavsky, Lauren D Kraemer Tardif, Lindsey Acrebuche, Christopher Puccia, Leiliane Sousa, Rita Zhou, Kyounghwa Bae, J Randolph Hecht, David P Carbone, Benny Johnson, Andrew Allen, Andrew R Ferguson, Karin Jooss
Therapeutic vaccines that elicit cytotoxic T cell responses targeting tumor-specific neoantigens hold promise for providing long-term clinical benefit to patients with cancer. Here we evaluated safety and tolerability of a therapeutic vaccine encoding 20 shared neoantigens derived from selected common oncogenic driver mutations as primary endpoints in an ongoing phase 1/2 study in patients with advanced/metastatic solid tumors. Secondary endpoints included immunogenicity, overall response rate, progression-free survival and overall survival...
March 27, 2024: Nature Medicine
https://read.qxmd.com/read/38538687/brain-network-hypersensitivity-underlies-pain-crises-in-sickle-cell-disease
#7
JOURNAL ARTICLE
Pangyu Joo, Minkyung Kim, Brianna Kish, Vidhya Vijayakrishnan Nair, Yunjie Tong, Ziyue Liu, Andrew R W O'Brien, Steven E Harte, Richard E Harris, UnCheol Lee, Ying Wang
Sickle cell disease (SCD) is a genetic disorder causing painful and unpredictable Vaso-occlusive crises (VOCs) through blood vessel blockages. In this study, we propose explosive synchronization (ES) as a novel approach to comprehend the hypersensitivity and occurrence of VOCs in the SCD brain network. We hypothesized that the accumulated disruptions in the brain network induced by SCD might lead to strengthened ES and hypersensitivity. We explored ES's relationship with patient reported outcome measures (PROMs) as well as VOCs by analyzing EEG data from 25 SCD patients and 18 matched controls...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38538579/naked-mole-rats-have-distinctive-cardiometabolic-and-genetic-adaptations-to-their-underground-low-oxygen-lifestyles
#8
JOURNAL ARTICLE
Chris G Faulkes, Thomas R Eykyn, Jan Lj Miljkovic, James D Gilbert, Rebecca L Charles, Hiran A Prag, Nikayla Patel, Daniel W Hart, Michael P Murphy, Nigel C Bennett, Dunja Aksentijevic
The naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovascular disease. To identify the mechanisms behind these exceptional traits, metabolomics and RNAseq of cardiac tissue from naked mole-rats was compared to other African mole-rat genera (Cape, Cape dune, Common, Natal, Mahali, Highveld and Damaraland mole-rats) and evolutionarily divergent mammals (Hottentot golden mole and C57/BL6 mouse). We identify metabolic and genetic adaptations unique to naked mole-rats including elevated glycogen, thus enabling glycolytic ATP generation during cardiac ischemia...
March 27, 2024: Nature Communications
https://read.qxmd.com/read/38536226/deployment-related-cigarette-smoking-behaviors-and-pulmonary-function-among-u-s-veterans
#9
JOURNAL ARTICLE
Jennifer R Maccarone, Olivia R Sterns, Andrew Timmons, Anna M Korpak, Nicholas L Smith, Karen S Nakayama, Coleen P Baird, Paul Ciminera, Farrah Kheradmand, Vincent S Fan, Jaime E Hart, Petros Koutrakis, Michael Jerrett, Ware G Kuschner, Octavian C Ioachimescu, Philippe R Montgrain, Susan P Proctor, Carrie A Redlich, Christine H Wendt, Paul D Blanc, Eric Garshick, Emily S Wan
INTRODUCTION: The effects of smoking on lung function among post-9/11 Veterans deployed to environments with high levels of ambient particulate matter are incompletely understood. MATERIALS AND METHODS: We analyzed interim data (04/2018-03/2020) from the Veterans Affairs (VA) Cooperative Studies Program #595, "Service and Health Among Deployed Veterans". Veterans with ≥1 land-based deployments enrolled at 1 of 6 regional Veterans Affairs sites completed questionnaires and spirometry...
March 25, 2024: Military Medicine
https://read.qxmd.com/read/38535968/east-meets-west-effect-of-acupuncture-on-lactation-and-maternal-quality-of-life
#10
JOURNAL ARTICLE
Cindy Baker-Fox, Jennifer Hayakawa, Ruth McCarty, Michelle Hart, John Schomberg, Smriti Shamapant, Christine Bixby
Objective: To evaluate the impact of acupuncture as part of a traditional Chinese medicine (TCM) treatment plan on lactation and maternal well-being in pump-dependent mothers of hospitalized neonates during the first 30 days after delivery. Study Design: This single-center study was conducted in a level IV regional neonatal intensive care unit with access to integrative health services. Sixty-six mothers were prospectively enrolled in two nonparallel groups: (1) Standard lactation support and (2) standard lactation support augmented with acupuncture...
March 27, 2024: Breastfeeding Medicine
https://read.qxmd.com/read/38534166/early-gastric-signet-ring-cell-adenocarcinoma-as-a-flat-pale-patch-on-an-esophagogastroduodenoscopy
#11
JOURNAL ARTICLE
Will Takakura, Shanti Eswaran, William D Chey, Hiroya Ueyama, Richard Kwon, Andrea Todisco, Scott Owens, Elena Stoffel, Oxana V Crysler, Filip Bednar, Benjamin R Hart
No abstract text is available yet for this article.
March 27, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38531896/accounting-for-albedo-change-to-identify-climate-positive-tree-cover-restoration
#12
JOURNAL ARTICLE
Natalia Hasler, Christopher A Williams, Vanessa Carrasco Denney, Peter W Ellis, Surendra Shrestha, Drew E Terasaki Hart, Nicholas H Wolff, Samantha Yeo, Thomas W Crowther, Leland K Werden, Susan C Cook-Patton
Restoring tree cover changes albedo, which is the fraction of sunlight reflected from the Earth's surface. In most locations, these changes in albedo offset or even negate the carbon removal benefits with the latter leading to global warming. Previous efforts to quantify the global climate mitigation benefit of restoring tree cover have not accounted robustly for albedo given a lack of spatially explicit data. Here we produce maps that show that carbon-only estimates may be up to 81% too high. While dryland and boreal settings have especially severe albedo offsets, it is possible to find places that provide net-positive climate mitigation benefits in all biomes...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38530954/differences-in-plasma-fatty-acid-composition-related-to-chronic-pancreatitis-a-pilot-study
#13
JOURNAL ARTICLE
Kristyn Gumpper-Fedus, Olivia Crowe, Phil A Hart, Valentina Pita-Grisanti, Ericka Velez-Bonet, Martha A Belury, Mitchell L Ramsey, Rachel M Cole, Niharika Badi, Stacey Culp, Alice Hinton, Luis F Lara, Somashekar G Krishna, Darwin L Conwell, Zobeida Cruz-Monserrate
OBJECTIVES: Chronic pancreatitis (CP) is an inflammatory disease affecting the absorption of fat-soluble nutrients. Signaling in pancreatic cells that lead to inflammation may be influenced by fatty acids (FAs) through diet and de novo lipogenesis. Here, we investigated the relationship between plasma FA composition in CP with heterogeneity of etiology and complications of CP. MATERIALS AND METHODS: Blood and clinical parameters were collected from subjects with CP (n = 47) and controls (n = 22)...
March 13, 2024: Pancreas
https://read.qxmd.com/read/38529810/medulloblastoma-in-a-child-with-osteoma-cutis%C3%A2-a-rare-association-due-to-loss-of-gnas-expression
#14
Jananie Suntharesan, Ekaterina Lyulcheva-Bennett, Rachel Hart, Barry Pizer, James Hayden, Renuka Ramakrishnan
OBJECTIVES: Inactivating GNAS mutations result in varied phenotypes depending on parental origin. Maternally inherited mutations typically lead to hormone resistance and Albright's hereditary osteodystrophy (AHO), characterised by short stature, round facies, brachydactyly and subcutaneous ossifications. Paternal inheritance presents with features of AHO or ectopic ossification without hormone resistance. This report describes the case of a child with osteoma cutis and medulloblastoma...
March 27, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38528766/systemic-intracellular-analysis-for-balancing-complex-biosynthesis-in-a-transcriptionally-deregulated-escherichia-coli-l-methionine-producer
#15
JOURNAL ARTICLE
Claudia Harting, Attila Teleki, Marius Braakmann, Frank Jankowitsch, Ralf Takors
l-Methionine (l-Met) has gained remarkable interest due to its multifaceted and versatile applications in the fields of nutrition, pharmaceuticals and clinical practice. In this study, the fluxes of the challenging l-Met biosynthesis in the producer strain Escherichia coli (E. coli) DM2853 were fine-tuned to enable improved l-Met production. The potential bottlenecks identified in sulfur assimilation and l-Met synthesis downstream of O-succinyl-l-homoserine (OSHS) were addressed by overexpressing glutaredoxin 1 (grxA), thiosulfate sulfurtransferase (pspE) and O-succinylhomoserine lyase (metB)...
March 2024: Microbial Biotechnology
https://read.qxmd.com/read/38526122/targeted-muscle-reinnervation-surgical-protocol-for-a-randomized-controlled-trial-in-postamputation-pain
#16
JOURNAL ARTICLE
Emily Pettersen, Paolo Sassu, Francesca Alice Pedrini, Hannes Granberg, Carina Reinholdt, Juan Manuel Breyer, Aidan Roche, Andrew Hart, Adil Ladak, Hollie A Power, Michael Leung, Michael Lo, Ian Valerio, Kyle R Eberlin, Theodore A Kung, Paul Cederna, Jason M Souza, Oskar Aszmann, Jason Ko, Gregory A Dumanian, Max Ortiz-Catalan
Over the past decade, the field of prosthetics has witnessed significant progress, particularly in the development of surgical techniques to enhance the functionality of prosthetic limbs. Notably, novel surgical interventions have had an additional positive outcome, as individuals with amputations have reported neuropathic pain relief after undergoing such procedures. Subsequently, surgical techniques have gained increased prominence in the treatment of postamputation pain, including one such surgical advancement - targeted muscle reinnervation (TMR)...
March 8, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38525258/post-traumatic-stress-and-future-substance-use-outcomes-leveraging-antecedent-factors-to-stratify-risk
#17
JOURNAL ARTICLE
Henri M Garrison-Desany, Jacquelyn L Meyers, Sarah D Linnstaedt, Stacey L House, Francesca L Beaudoin, Xinming An, Donglin Zeng, Thomas C Neylan, Gari D Clifford, Tanja Jovanovic, Laura T Germine, Kenneth A Bollen, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Robert A Swor, Nina T Gentile, Lauren A Hudak, Jose L Pascual, Mark J Seamon, Erica Harris, Claire Pearson, David A Peak, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Leon D Sanchez, Steven E Bruce, Jutta Joormann, Steven E Harte, Samuel A McLean, Karestan C Koenen, Christy A Denckla
BACKGROUND: Post-traumatic stress disorder (PTSD) and substance use (tobacco, alcohol, and cannabis) are highly comorbid. Many factors affect this relationship, including sociodemographic and psychosocial characteristics, other prior traumas, and physical health. However, few prior studies have investigated this prospectively, examining new substance use and the extent to which a wide range of factors may modify the relationship to PTSD. METHODS: The Advancing Understanding of RecOvery afteR traumA (AURORA) study is a prospective cohort of adults presenting at emergency departments (N = 2,943)...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38522649/sex-differences-in-response-inhibition-related-neural-predictors-of-ptsd-in-recent-trauma-exposed-civilians
#18
JOURNAL ARTICLE
Bibian Borst, Tanja Jovanovic, Stacey L House, Steven E Bruce, Nathaniel G Harnett, Alyssa R Roeckner, Timothy D Ely, Lauren A M Lebois, Dmitri Young, Francesca L Beaudoin, Xinming An, Thomas C Neylan, Gari D Clifford, Sarah D Linnstaedt, Laura T Germine, Kenneth A Bollen, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Lauren A Hudak, Jose L Pascual, Mark J Seamon, Elizabeth M Datner, Claire Pearson, David A Peak, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Leon D Sanchez, Steven E Harte, Karestan C Koenen, Ronald C Kessler, Samuel A McLean, Kerry J Ressler, Jennifer S Stevens, Sanne J H van Rooij
BACKGROUND: Females are more likely to develop posttraumatic stress disorder (PTSD) than males. Impaired inhibition has been identified as mechanism for PTSD development, but studies on the potential sex differences of this neurobiological mechanism and how it relates to PTSD severity and progression are sparse. Here we examined sex differences in neural activation during response inhibition and PTSD following recent trauma. METHODS: Participants (N= 205, 138 female sex assigned at birth) were recruited from emergency departments within 72 hours of a traumatic event...
March 22, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://read.qxmd.com/read/38522542/indoor-and-ambient-black-carbon-and-fine-particulate-matter-associations-with-blood-biomarkers-in-copd-patients
#19
JOURNAL ARTICLE
Cathy L Zhang, Jennifer R Maccarone, Stephanie T Grady, Christina M Collins, Marilyn L Moy, Jaime E Hart, Choong-Min Kang, Brent A Coull, Joel D Schwartz, Petros Koutrakis, Eric Garshick
BACKGROUND: Systemic inflammation contributes to cardiovascular risk and chronic obstructive pulmonary disease (COPD) pathophysiology. Associations between systemic inflammation and exposure to ambient fine particulate matter (PM ≤ 2.5 μm diameter; PM2.5 ), and black carbon (BC), a PM2.5 component attributable to traffic and other sources of combustion, infiltrating indoors are not well described. METHODS: Between 2012 and 2017, COPD patients completed in-home air sampling over one-week intervals, up to four times (seasonally), followed by measurement of plasma biomarkers of systemic inflammation, C-reactive protein (CRP) and interleukin-6 (IL-6), and endothelial activation, soluble vascular adhesion molecule-1 (sVCAM-1)...
March 22, 2024: Science of the Total Environment
https://read.qxmd.com/read/38521480/what-role-does-striatal-dopamine-play-in-goal-directed-action
#20
REVIEW
Genevra Hart, Thomas J Burton, Bernard W Balleine
Evidence suggests that dopamine activity provides a US-related prediction error for Pavlovian conditioning and the reinforcement signal supporting the acquisition of habits. However, its role in goal-directed action is less clear. There are currently few studies that have assessed dopamine release as animals acquire and perform self-paced instrumental actions. Here we briefly review the literature documenting the psychological, behavioral and neural bases of goal-directed actions in rats and mice, before turning to describe recent studies investigating the role of dopamine in instrumental learning and performance...
March 21, 2024: Neuroscience
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