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Alzheimers and nutrition

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https://www.readbyqxmd.com/read/29231845/maillard-proteomics-opening-new-pages
#1
REVIEW
Alena Soboleva, Rico Schmidt, Maria Vikhnina, Tatiana Grishina, Andrej Frolov
Protein glycation is a ubiquitous non-enzymatic post-translational modification, formed by reaction of protein amino and guanidino groups with carbonyl compounds, presumably reducing sugars and α-dicarbonyls. Resulting advanced glycation end products (AGEs) represent a highly heterogeneous group of compounds, deleterious in mammals due to their pro-inflammatory effect, and impact in pathogenesis of diabetes mellitus, Alzheimer's disease and ageing. The body of information on the mechanisms and pathways of AGE formation, acquired during the last decades, clearly indicates a certain site-specificity of glycation...
December 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29178502/survival-times-with-and-without-tube-feeding-in-patients-with-dementia-or-psychiatric-diseases-in-japan
#2
Keiko Takayama, Keisuke Hirayama, Akihiko Hirao, Keiko Kondo, Hideki Hayashi, Koichi Kadota, Hiroyuki Asaba, Hideki Ishizu, Kenji Nakata, Kairi Kurisu, Etsuko Oshima, Osamu Yokota, Norihito Yamada, Seishi Terada
BACKGROUND: It is widely supposed that there has been no evidence of increased survival in patients with advanced dementia receiving enteral tube feeding. However, more than a few studies have reported no harmful outcome from tube feeding in dementia patients compared to in patients without dementia. METHODS: This was a retrospective study. Nine psychiatric hospitals in Okayama Prefecture participated in this survey. All inpatients fulfilling the entry criteria were evaluated...
November 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29172062/association-of-nutrition-and-immune-endocrine-dysfunction-with-muscle-mass-and-performance-in-cognitively-impaired-older-adults
#3
L Tay, B P Leung, S Wee, K S Tay, N Ali, M Chan, W S Lim
BACKGROUND: With lean mass declining early in Alzheimer's disease, muscle quality beyond quantity is relevant to physical performance. We sought to identify potentially modifiable factors for the differential loss of muscle mass (pre-sarcopenia) and its performance (sarcopenia) in older adults with mild cognitive impairment (MCI) and mild-to-moderate Alzheimer's disease (AD). METHODS: This is a cross-sectional study of 108 community-dwelling older adults with MCI and mild-to-moderate AD...
November 16, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29164314/cross-national-gender-variations-of-digit-ratio-2d-4d-correlate-with-life-expectancy-suicide-rate-and-other-causes-of-death
#4
Bernd Lenz, Johannes Kornhuber
The second-to-fourth finger length ratio (2D:4D) is an indication of prenatal sex hormone exposure, and has sex-specifically been associated with several lethal illnesses including ischemic heart disease, diverse cancers, and suicide. Our primary aim was to verify that 2D:4D sex-specifically relates to life expectancy and suicide numbers on a national level (23 countries). We also used a hypothesis-free approach to investigate associations with other causes of death [p value adjustment for multiple hypothesis testing using the false discovery rate procedure (FDR)]...
November 21, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29157223/tube-feeding-decreases-pneumonia-rate-in-patients-with-severe-dementia-comparison-between-pre-and-post-intervention
#5
Shintaro Takenoshita, Keiko Kondo, Keiichi Okazaki, Akihiko Hirao, Keiko Takayama, Keisuke Hirayama, Hiroyuki Asaba, Kenji Nakata, Hideki Ishizu, Hiromi Takahashi, Hanae Nakashima-Yasuda, Yasue Sakurada, Kengo Fujikawa, Osamu Yokota, Norihito Yamada, Seishi Terada
BACKGROUND: It is widely supposed that there is no benefit, including extended survival and decreased rate of pneumonia, in patients with severe dementia receiving enteral tube feeding (TF). However, there have been few studies comparing the frequency of pneumonia before and after TF in severe dementia. METHODS: Nine psychiatric hospitals in Okayama Prefecture participated in this retrospective survey. All inpatients fulfilling the entry criteria were evaluated...
November 21, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29154736/lactobacilli-fermented-cow-s-milk-attenuated-lipopolysaccharide-induced-neuroinflammation-and-memory-impairment-in-vitro-and-in-vivo
#6
Nurul Huda Musa, Vasudevan Mani, Siong Meng Lim, Sharmili Vidyadaran, Abu Bakar Abdul Majeed, Kalavathy Ramasamy
Nutritional interventions are now recommended as strategies to delay Alzheimer's disease (AD) progression. The present study evaluated the neuroprotective effect (anti-inflammation) of lactic acid bacteria (either Lactobacillus fermentum LAB9 or L. casei LABPC) fermented cow's milk (CM) against lipopolysaccharide (LPS)-activated microglial BV2 cells in vitro. The ability of CM-LAB in attenuating memory deficit in LPS-induced mice was also investigated. ICR mice were orally administered with CM-LAB for 28 d before induction of neuroinflammation by LPS...
November 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/29141977/vitamins-associated-with-brain-aging-mild-cognitive-impairment-and-alzheimer-disease-biomarkers-epidemiological-and-experimental-evidence-plausible-mechanisms-and-knowledge-gaps
#7
REVIEW
Michael Fenech
The key to preventing brain aging, mild cognitive impairment (MCI), and Alzheimer disease (AD) via vitamin intake is first to understand molecular mechanisms, then to deduce relevant biomarkers, and subsequently to test the level of evidence for the impact of vitamins in the relevant pathways and their modulation of dementia risk. This narrative review infers information on mechanisms from gene and metabolic defects associated with MCI and AD, and assesses the role of vitamins using recent results from animal and human studies...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29136094/effects-of-multidomain-lifestyle-intervention-omega-3-supplementation-or-their-combination-on-physical-activity-levels-in-older-adults-secondary-analysis-of-the-multidomain-alzheimer-preventive-trial-mapt-randomised-controlled-trial
#8
Philipe de Souto Barreto, Yves Rolland, Matteo Cesari, Charlotte Dupuy, Sandrine Andrieu, Bruno Vellas
Background/objectives: to investigate the effects of a 3-year multidomain lifestyle intervention, omega-3 supplementation or both on physical activity (PA) in older adults with subjective memory complaints. Design/settings/subjects: the Multidomain Alzheimer Preventive Trial was a 3-year randomised controlled trial that enroled 1,680 community-dwelling adults aged 70 years or over, with subjective memory complaints. Participants were randomised to omega-3 supplementation (total daily dose of 800 mg docosahexanoic acid and up to 225 mg eicosapentanoic acid), multidomain intervention (nutritional and exercise counselling and cognitive training), omega-3 plus multidomain intervention or placebo with usual care...
November 10, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29131706/alzheimer-s-disease-current-status-and-future-directions
#9
Deepshikha Bhardwaj, Connie Mitra, Chandrakala Aluganti Narasimhulu, Aladdin Riad, Mitsushita Doomra, Sampath Parthasarathy
Alzheimer's disease (AD) is an age-related neurodegenerative disorder of the brain. The presence of amyloid-beta (Aβ) plaques, neurofibrillary tangles (NFTs), loss of neurons, synapses, and altered sensory perceptions, including memory loss, delineate AD. However, the cause of AD is not clearly known. Several genetic and nongenetic factors have been implicated in the disease. Of the genes, the ɛ4 allele of apolipoprotein E is the largest known genetic risk factor of AD. This review article focuses on the various genetic and other predisposing factors that account for AD, pathophysiology of the disease, and the mechanisms by which Aβ plaques and NFTs are formed and could affect AD brain...
November 13, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29107872/inflammation-and-gut-brain-axis-link-obesity-to-cognitive-dysfunction-plausible-pharmacological-interventions
#10
REVIEW
Maite Solas, Fermin I Milagro, María J Ramírez, J Alfredo Martínez
Obesity prevalence is increasing steadily throughout the world's population in most countries and in parallel the prevalence of metabolic disorders including cardiovascular diseases and type 2 diabetes is also rising, but less is reported about excessive adiposity relationship with poorer cognitive performance, cognitive decline and dementia. Some human clinical studies have evidenced that obesity is related to the risk of the development of mild cognitive impairment, in the form of short-term memory and executive function deficits, as well as dementia and Alzheimer's disease...
November 3, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29103035/immunotherapy-of-mild-cognitive-impairment-by-%C3%AF-3-supplementation-why-are-amyloid-%C3%AE-antibodies-and-%C3%AF-3-not-working-in-clinical-trials
#11
Milan Fiala, Lucas Restrepo, Matteo Pellegrini
This article reviews the basic tenets of a clinical approach to effective immunotherapy of Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Although one randomized controlled study in early MCI patients by fish-derived omega-3 fatty acids (ω-3) showed slowing of disease progression, large clinical trials with different products have failed to show cognitive effects. Macrophages of healthy subjects phagocytize and degrade amyloid-β1 - 42 (Aβ) in the brain tissues, whereas macrophages of patients with AD and MCI are functionally defective...
October 30, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29097166/24-month-intervention-with-a-specific-multinutrient-in-people-with-prodromal-alzheimer-s-disease-lipididiet-a-randomised-double-blind-controlled-trial
#12
Hilkka Soininen, Alina Solomon, Pieter Jelle Visser, Suzanne B Hendrix, Kaj Blennow, Miia Kivipelto, Tobias Hartmann
BACKGROUND: Nutrition is an important modifiable risk factor in Alzheimer's disease. Previous trials of the multinutrient Fortasyn Connect showed benefits in mild Alzheimer's disease dementia. LipiDiDiet investigated the effects of Fortasyn Connect on cognition and related measures in prodromal Alzheimer's disease. Here, we report the 24-month results of the trial. METHODS: LipiDiDiet was a 24-month randomised, controlled, double-blind, parallel-group, multicentre trial (11 sites in Finland, Germany, the Netherlands, and Sweden), with optional 12-month double-blind extensions...
December 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29067349/serum-concentrations-of-vitamin-e-and-carotenoids-are-altered-in-alzheimer-s-disease-a-case-control-study
#13
Kathryn Mullan, Michael A Williams, Chris R Cardwell, Bernadette McGuinness, Peter Passmore, Giuliana Silvestri, Jayne V Woodside, Gareth J McKay
INTRODUCTION: Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). We investigated associations between serum levels of lipophilic antioxidants and AD. METHODS: Serum concentrations of retinol, two forms of vitamin E (α- and γ-tocopherol) and six carotenoids were quantified by high-performance liquid chromatography from patients with AD (n = 251) and cognitively intact controls (n = 308) and assessed by regression analyses...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29067348/lower-brain-and-blood-nutrient-status-in-alzheimer-s-disease-results-from-meta-analyses
#14
REVIEW
Martijn C de Wilde, Bruno Vellas, Elodie Girault, Aysun Cetinyurek Yavuz, John W Sijben
INTRODUCTION: Alzheimer's disease (AD) patients are at risk of nutritional insufficiencies because of physiological and psychological factors. Recently, we showed the results of the meta-analyses indicating lower plasma levels of vitamins A, B12, C, E, and folate in AD patients compared with cognitively intact elderly controls (controls). Now, additional and more extensive literature searches were performed selecting studies which compare blood and brain/cerebrospinal fluid (CSF) levels of vitamins, minerals, trace elements, micronutrients, and fatty acids in AD patients versus controls...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29067310/design-of-the-nl-enigma-study-exploring-the-effect-of-souvenaid-on-cerebral-glucose-metabolism-in-early-alzheimer-s-disease
#15
Nienke M E Scheltens, Ingrid S Kuyper, Ronald Boellaard, Frederik Barkhof, Charlotte E Teunissen, Laus M Broersen, Marieke M Lansbergen, Wiesje M van der Flier, Bart N M van Berckel, Philip Scheltens
INTRODUCTION: Alzheimer's disease is associated with early synaptic loss. Specific nutrients are known to be rate limiting for synapse formation. Studies have shown that administering specific nutrients may improve memory function, possibly by increasing synapse formation. This Dutch study explores the Effect of a specific Nutritional Intervention on cerebral Glucose Metabolism in early Alzheimer's disease (NL-ENIGMA, Dutch Trial Register NTR4718, http://www.trialregister.nl/trialreg/admin/rctview...
November 2016: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29037152/low-plasma-tryptophan-is-associated-with-olfactory-function-in-healthy-elderly-community-dwellers-in-japan
#16
Yusuke Adachi, Yoshiki Shimodaira, Hidehiro Nakamura, Akira Imaizumi, Maiko Mori, Yoko Kageyama, Yasushi Noguchi, Asuka Seki, Yuki Okabe, Yuko Miyake, Kaori Ono, Shu Kumagai
BACKGROUND: Decreased circulating tryptophan (Trp) levels are frequently observed in elderly patients with neurodegenerative disease including Alzheimer's disease. Trp may serve as a potential biomarker for monitoring disease risk in elderly people. We aimed to investigate the association between low plasma Trp levels and olfactory function, which is known to predict age-related diseases including dementia in elderly people. METHODS: A total of 144 healthy elderly Japanese community (≥ 65 years old) dwellers from the Health, Aging and Nutritional Improvement study (HANI study) were the subjects of our analysis...
October 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29035971/dietary-patterns-and-cognition-in-older-persons
#17
Angela M Abbatecola, Marcello Russo, Michelangela Barbieri
PURPOSE OF REVIEW: The current article reviews recently published evidence of the important role that specific dietary patterns may hold on preventing cognitive impairment and dementia over aging. RECENT FINDINGS: Specific dietary patterns attributed to targeting cardiovascular risk factors may protect against the development of mild cognitive impairment (MCI) and dementia, especially Alzheimer's disease. Numerous epidemiological studies have strongly suggested that multinutrient approaches using the Mediterranean diet (Med diet), dietary approach to systolic hypertension (DASH) and the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) are associated with a lower risk of cognitive impairment, MCI and Alzheimer's disease in older persons...
January 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28973985/s-adenosylmethionine-and-superoxide-dismutase-1-synergistically-counteract-alzheimer-s-disease-features-progression-in-tgcrnd8-mice
#18
Rosaria A Cavallaro, Vincenzina Nicolia, Maria Teresa Fiorenza, Sigfrido Scarpa, Andrea Fuso
Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer's Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated by one-carbon metabolism, leading to increased amyloid production. We have also demonstrated that S-adenosylmethionine (SAM) supplementation contrasted the AD-like features, induced by B-vitamin deficiency. In the present study, we expanded these observations by investigating the effects of SAM and SOD (Superoxide dismutase) association...
September 30, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28949318/psychogeriatric-diagnoses-in-old-people-s-homes-and-negative-health-behavior
#19
Spomenka Tomek-Roksandić, Ivana Popek, Nada Tomasović Mrčela, Zvonimir Šostar, Branko Kolarić, Nina Smolej Narančić, Ana Stavljenić Rukavina, Mate Ljubičić
BACKGROUND: The study was designed as a gerontologic-public health analysis of the relationship between the leading and accompanying psychogeriatric diagnoses and negative health behaviors recorded in the old people's home users, with the aim to evaluate and redefine gerontologic-public health priorities and geroprophylactic measures, with special reference to persons suffering from Alzheimer's disease and other dementias. SUBJECT AND METHODS: Gerontologic-public health indicators obtained by monitoring health care needs of the elderly in specific institutional primary health care at 10 old people's homes (N=1185) in Croatia in 2013 were analyzed using the professional methodology developed at Department of Health Gerontology, Andrija Štampar Teaching Institute of Public Health (Registry List 1 that refers to monitoring specific primary health care needs of elderly at old people's homes)...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28936398/vitamin-d-is-associated-with-severity-and-mortality-of-non-alcoholic-fatty-liver-disease-a-us-population-based-study
#20
Hyun-Seok Kim, Laura Rotundo, Neil Kothari, Sung-Hoon Kim, Nikolaos Pyrsopoulos
Background and Aims: There has been increasing evidence that vitamin D deficiency may increase the risk of metabolic syndrome. Since metabolic syndrome is a major risk factor for non-alcoholic fatty liver disease (NAFLD), we aimed to investigate the association between vitamin D and the severity and mortality of NAFLD. Methods: Data was obtained from the United States Third National Health and Nutrition Examination Survey conducted in 1988-1994, with follow-up mortality data through 2011. NAFLD was defined by ultrasonographic detection of hepatic steatosis in the absence of other liver diseases and categorized as normal, mild, moderate or severe...
September 28, 2017: Journal of Clinical and Translational Hepatology
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