keyword
MENU ▼
Read by QxMD icon Read
search

Alzheimers and nutrition

keyword
https://www.readbyqxmd.com/read/27869786/a-role-for-leucoanthocyanidin-reductase-in-the-extension-of-proanthocyanidins
#1
Chenggang Liu, Xiaoqiang Wang, Vladimir Shulaev, Richard A Dixon
Proanthocyanidins (PAs) are the second most abundant plant polyphenolic compounds after lignin. PAs affect taste, mouth feel and astringency of many fruits, wines and beverages(1,2), have been associated with reduced risks of cardiovascular disease, cancer and Alzheimer's disease(3-5), can improve nutrition and prevent bloat in ruminant animals(6) and enhance soil nitrogen retention(7). PAs are oligomers and polymers of flavan-3-ols, primarily (-)-epicatechin and (+)-catechin, but the mechanism by which the monomers polymerize and become insoluble is currently unknown...
November 21, 2016: Nature Plants
https://www.readbyqxmd.com/read/27866493/dietary-dha-and-health-cognitive-function-ageing
#2
Carlos Cardoso, Cláudia Afonso, Narcisa M Bandarra
DHA is a key nutritional n-3 PUFA and needs to be supplied by the human diet. DHA is found in significant amounts in the retinal and neuronal cell membranes due to its high fluidity. Indeed, DHA is selectively concentrated in the synaptic and retinal membranes. DHA is deemed to display anti-inflammatory properties and to reduce the risk of CVD. Consumption of larger amounts of DHA appears to reduce the risk of depression, bipolar disorder, schizophrenia and mood disorders. Conversely, it has been shown that loss of DHA from the nerve cell membrane leads to dysfunction of the central nervous system in the form of anxiety, irritability, susceptibility to stress, dyslexia, impaired memory and cognitive functions, and extended reaction times...
November 21, 2016: Nutrition Research Reviews
https://www.readbyqxmd.com/read/27862176/inflammasomes-hormesis-and-antioxidants-in-neuroinflammation-role-of-nrlp3-in-alzheimer-disease
#3
REVIEW
Manuela Pennisi, Rosalia Crupi, Rosanna Di Paola, Maria Laura Ontario, Rita Bella, Edward J Calabrese, Roberto Crea, Salvatore Cuzzocrea, Vittorio Calabrese
Alzheimer disease (AD) is a progressive neurodegenerative disorder leading to cognitive decline, neuropsychiatric symptoms, disability, caregiver burden, and premature death. It represents the most prevalent cause of dementia, and its incidence rates exponentially increase with increasing age. The number of Americans living with AD is rapidly increasing. An estimated 5.4 million Americans of all ages have AD in 2016. One in nine people aged 65 and older has AD, and by midcentury, someone in the United States will develop the disease every 33 sec...
November 8, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27801864/tocotrienol-affects-oxidative-stress-cholesterol-homeostasis-and-the-amyloidogenic-pathway-in-neuroblastoma-cells-consequences-for-alzheimer-s-disease
#4
Marcus O W Grimm, Liesa Regner, Janine Mett, Christoph P Stahlmann, Pascal Schorr, Christopher Nelke, Olga Streidenberger, Hannah Stoetzel, Jakob Winkler, Shatha R Zaidan, Andrea Thiel, Kristina Endres, Heike S Grimm, Dietrich A Volmer, Tobias Hartmann
One of the characteristics of Alzheimer´s disease (AD) is an increased amyloid load and an enhanced level of reactive oxidative species (ROS). Vitamin E has known beneficial neuroprotective effects, and previously, some studies suggested that vitamin E is associated with a reduced risk of AD due to its antioxidative properties. However, epidemiological studies and nutritional approaches of vitamin E treatment are controversial. Here, we investigate the effect of α-tocotrienol, which belongs to the group of vitamin E, on AD-relevant processes in neuronal cell lines...
October 29, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27757515/high-throughput-and-simultaneous-quantitative-analysis-of-homocysteine-methionine-cycle-metabolites-and-co-factors-in-blood-plasma-and-cerebrospinal-fluid-by-isotope-dilution-lc-ms-ms
#5
Seu Ping Guiraud, Ivan Montoliu, Laeticia Da Silva, Loïc Dayon, Antonio Núñez Galindo, John Corthésy, Martin Kussmann, Francois-Pierre Martin
The methionine cycle is a key pathway contributing to the regulation of human health, with well-established involvement in cardiovascular diseases and cognitive function. Changes in one-carbon cycle metabolites have also been associated with mild cognitive decline, vascular dementia, and Alzheimer's disease. Today, there is no single analytical method to monitor both metabolites and co-factors of the methionine cycle. To address this limitation, we here report for the first time a new method for the simultaneous quantitation of 17 metabolites in the methionine cycle, which are homocysteic acid, taurine, serine, cysteine, glycine, homocysteine, riboflavin, methionine, pyridoxine, cystathionine, pyridoxamine, S-adenosylhomocysteine, S-adenosylmethionine, betaine, choline, dimethylglycine, and 5-methyltetrahydrofolic acid...
October 18, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27736877/no-overt-deficits-in-aged-tau-deficient-c57bl-6-mapttm1-egfp-kit-gfp-knockin-mice
#6
Annika van Hummel, Mian Bi, Stefania Ippati, Julia van der Hoven, Alexander Volkerling, Wei S Lee, Daniel C S Tan, Andre Bongers, Arne Ittner, Yazi D Ke, Lars M Ittner
Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau reduction prevented Aβ-induced deficits in mouse models of Alzheimer's disease. However, the effects of long-term depletion of tau in vivo remained controversial. Here, we used the tau-deficient GFP knockin line Mapttm1(EGFP)kit on a pure C57Bl/6 background and subjected a large cohort of males and females to a range of motor, memory and behavior tests and imaging analysis, at the advanced age of over 16 months...
2016: PloS One
https://www.readbyqxmd.com/read/27733281/global-regional-and-national-life-expectancy-all-cause-mortality-and-cause-specific-mortality-for-249-causes-of-death-1980-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#7
COMMENT
(no author information available yet)
BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. METHODS: We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010...
October 8, 2016: Lancet
https://www.readbyqxmd.com/read/27719968/-pharmacological-treatment
#8
Enrique Arriola Manchola, Javier Álaba Trueba
Alzheimer's disease (AD) is a chronic degenerative and inflammatory process leading to synapticdysfunction and neuronal death. A review about the pharmacological treatment alternatives is made: acetylcholinesterase inhibitors (AChEI), a nutritional supplement (Souvenaid) and Ginkgo biloba. A special emphasis on Ginkgo biloba due to the controversy about its use and the approval by the European Medicines Agency is made.
June 2016: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/27716664/normal-vitamin-levels-and-nutritional-indices-in-alzheimer-s-disease-patients-with-mild-cognitive-impairment-or-dementia-with-normal-body-mass-indexes
#9
Ingun Ulstein, Thomas Bøhmer
Evidence supports an association between vitamin deficiencies and cognitive decline in Alzheimer's disease (AD). If vitamin deficiencies are causative for AD development, they should be detectable during very early stages of AD. Here we investigated nutritional factors among home-living patients diagnosed with mild cognitive impairment (MCI) or mild dementia due to AD, compared to healthy controls. Our study included 73 patients with AD (25 with MCI, 48 with dementia) and 63 cognitively intact age-matched controls...
October 5, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27659393/optimal-cutoff-scores-for-alzheimer-s-disease-using-the-chinese-version-of-mini-mental-state-examination-among-chinese-population-living-in-rural-areas
#10
Zhao Yang, Hunter K Holt, Jin-Hu Fan, Li Ma, Ying Liu, Wen Chen, Peter Como, Lin Zhang, You-Lin Qiao
To explore the optimal cutoff score for initial detection of Alzheimer's Disease (AD) through the Chinese version of Mini-Mental State Examination (CMMSE) in rural areas in China, we conducted a cross-sectional study within the Linxian General Population Nutritional Follow-up study. 16,488 eligible cohort members participated in the survey and 881 completed the CMMSE. Among 881 participants, the median age (Interquartile range) was 69.00 (10.00), 634 (71.92%) were female, 657 (74.57%) were illiterate, 35 (3...
September 22, 2016: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27651256/role-of-quercetin-benefits-in-neurodegeneration
#11
Preetham Elumalai, Sreeja Lakshmi
Neurodegenerative disorders are often life threatening and hired as an economic burden to the health-care system. Nutritional interventions principally involving polyphenols were practiced to arrest or reverse the age-related health disorders. Flavonoids, a class of dietary polyphenols, are rising to superstardom in preventing brain disorders with their potent antioxidant defense mechanism. Quercetin is a ubiquitous flavonoid reported to have all-natural myriad of health benefits. Citrus fruits, apple, onion, parsley, berries, green tea, and red wine comprise the major dietary supplements of quercetin apart from some herbal remedies like Ginkgo biloba...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27636852/health-advice-in-a-digital-world-quality-and-content-of-online-information-about-the-prevention-of-alzheimer-s-disease
#12
Julie M Robillard, Tanya L Feng
BACKGROUND: As the number of older adults turning to the Internet for health information increases, so does the potential for online information to have a substantial impact on the patient-physician relationship and on their health. Inaccurate information may weaken patient-physician relationships or result in increased physician visits and health-anxiety, while high quality information may allow Internet users to make better decisions about their health. OBJECTIVE: To assess the quality and content of available online resources about the prevention of Alzheimer's disease (AD)...
September 12, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27636839/nutritional-status-of-patients-with%C3%A2-alzheimer-s-disease-and-their-caregivers
#13
Mario Tombini, Maura Sicari, Giovanni Pellegrino, Francesca Ursini, Pasqualina Insardá, Vincenzo Di Lazzaro
BACKGROUND: Malnutrition is one of the most important conditions that negatively affects the health of elder people, particularly in patients with dementia. OBJECTIVE: To provide an assessment of nutritional status of patients affected by Alzheimer's disease (AD) living at home and of their caregivers by means of Mini Nutritional Assessment (MNA), and to explore the influence of different factors on nutrition. METHODS: 90 patients affected by AD living at home and 90 age- and sex-matched caregivers were enrolled...
October 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27634977/role-of-gut-microbiota-and-nutrients-in-amyloid-formation-and-pathogenesis-of-alzheimer-disease
#14
Francesca Pistollato, Sandra Sumalla Cano, Iñaki Elio, Manuel Masias Vergara, Francesca Giampieri, Maurizio Battino
It has been hypothesized that alterations in the composition of the gut microbiota might be associated with the onset of certain human pathologies, such as Alzheimer disease, a neurodegenerative syndrome associated with cerebral accumulation of amyloid-β fibrils. It has been shown that bacteria populating the gut microbiota can release significant amounts of amyloids and lipopolysaccharides, which might play a role in the modulation of signaling pathways and the production of proinflammatory cytokines related to the pathogenesis of Alzheimer disease...
October 2016: Nutrition Reviews
https://www.readbyqxmd.com/read/27633107/recent-findings-in-alzheimer-disease-and-nutrition-focusing-on-epigenetics
#15
REVIEW
Dimitrios Athanasopoulos, George Karagiannis, Magda Tsolaki
Alzheimer disease (AD) is a chronic neurodegenerative disease with no effective cure so far. The current review focuses on the epigenetic mechanisms of AD and how nutrition can influence the course of this disease through regulation of gene expression, according to the latest scientific findings. The search strategy was the use of scientific databases such as PubMed and Scopus in order to find relative research or review articles published in the years 2012-2015. By showing the latest data of various nutritional compounds, this study aims to stimulate the scientific community to recognize the value of nutrition in this subject...
September 2016: Advances in Nutrition
https://www.readbyqxmd.com/read/27604604/the-gut-brain-axis-including-the-microbiome-leaky-gut-and-bacterial-translocation-mechanisms-and-pathophysiological-role-in-alzheimer-s-disease
#16
Cristiano A Köhler, Michael Maes, Anastasiya Slyepchenko, Michael Berk, Marco Solmi, Krista L Lanctôt, André F Carvalho
Alzheimer's disease (AD), the most common form of dementia, is a progressive disorder manifested by gradual memory loss and subsequent impairment in mental and behavioral functions. Though the primary risk factor for AD is advancing age, other factors such as diabetes mellitus, hyperlipidemia, obesity, vascular factors and depression play a role in its pathogenesis. The human gastrointestinal tract has a diverse commensal microbial population, which has bidirectional interactions with the human host that are symbiotic in health, and in addition to nutrition, digestion, plays major roles in inflammation and immunity...
September 6, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27579313/dha-and-epa-content-and-fatty-acid-profile-of-39-food-fishes-from-india
#17
Bimal Prasanna Mohanty, Satabdi Ganguly, Arabinda Mahanty, T V Sankar, R Anandan, Kajal Chakraborty, B N Paul, Debajit Sarma, J Syama Dayal, G Venkateshwarlu, Suseela Mathew, K K Asha, D Karunakaran, Tandrima Mitra, Soumen Chanda, Neetu Shahi, Puspita Das, Partha Das, Md Shahbaz Akhtar, P Vijayagopal, N Sridhar
Docosahexaenoic acid (DHA) is the principal constituent of a variety of cells especially the brain neurons and retinal cells and plays important role in fetal brain development, development of motor skills, and visual acuity in infants, lipid metabolism, and cognitive support and along with eicosapentaenoic acid (EPA) it plays important role in preventing atherosclerosis, dementia, rheumatoid arthritis, Alzheimer's disease, and so forth. Being an essential nutrient, it is to be obtained through diet and therefore searching for affordable sources of these ω-3 polyunsaturated fatty acids (PUFA) is important for consumer guidance and dietary counseling...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27493875/salidroside-alleviates-cachexia-symptoms-in-mouse-models-of-cancer-cachexia-via-activating-mtor-signalling
#18
Xiangzheng Chen, Yangping Wu, Tinghan Yang, Mingtian Wei, Yuxi Wang, Xiangbing Deng, Congcong Shen, Wenting Li, Hang Zhang, Weiyong Xu, Lantu Gou, Yong Zeng, Yonghui Zhang, Ziqiang Wang, Jinliang Yang
BACKGROUND: Cachexia has a devastating impact on survival and quality of life for many cancer patients and contributes to nearly one-third of all cancer deaths; also, it is associated with poor responses to chemotherapy and survival. A better understanding of the underlying mechanisms of cancer-associated cachexia (CAC), coupled with effective therapeutic approaches, will improve management of progressive functional impairment in cancer patients. Salidroside, a phenylpropanoid glycoside in Rhodiola rosea L, has been reported to possess potential anti-fatigue, anti-ageing, and anti-Alzheimer's disease properties...
May 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27473185/dietary-arachidonic-acid-as-a-risk-factor-for-age-associated-neurodegenerative-diseases-potential-mechanisms
#19
Mélanie H Thomas, Sandra Pelleieux, Nicolas Vitale, Jean Luc Olivier
Alzheimer's disease and associated diseases constitute a major public health concern worldwide. Nutrition-based, preventive strategies could possibly be effective in delaying the occurrence of these diseases and lower their prevalence. Arachidonic acid is the second major polyunsaturated fatty acid (PUFA) and several studies support its involvement in Alzheimer's disease. The objective of this review is to examine how dietary arachidonic acid contributes to Alzheimer's disease mechanisms and therefore to its prevention...
July 26, 2016: Biochimie
https://www.readbyqxmd.com/read/27465436/selenomethionine-reduces-the-deposition-of-beta-amyloid-plaques-by-modulating-%C3%AE-secretase-and-enhancing-selenoenzymatic-activity-in-a-mouse-model-of-alzheimer-s-disease
#20
Zhong-Hao Zhang, Chen Chen, Qiu-Yan Wu, Rui Zheng, Qiong Liu, Jia-Zuan Ni, Peter R Hoffmann, Guo-Li Song
Alzheimer's disease (AD) is characterized by the production of large amounts of beta-amyloid (Aβ) and the accumulation of extracellular senile plaques, which have been considered to be potential targets in the treatment of AD. Selenium (Se) is a nutritionally essential trace element with known antioxidant potential and Se status has been shown to decrease with age and has a close relationship with cognitive competence in AD. Selenomethionine (Se-Met), a major reserve form of Se in organisms, has been shown in our previous study to ameliorate the decline in cognitive function, increase oxidation resistance, and reduce tau hyperphosphorylation in a triple transgenic mouse model of AD...
August 1, 2016: Metallomics: Integrated Biometal Science
keyword
keyword
19388
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"