keyword
MENU ▼
Read by QxMD icon Read
search

Alzheimers and nutrition

keyword
https://www.readbyqxmd.com/read/29909178/the-effect-of-apoe-genotype-on-alzheimer-s-disease-risk-is-influenced-by-sex-and-docosahexaenoic-acid-status
#1
REVIEW
Matthew Pontifex, David Vauzour, Anne-Marie Minihane
An apolipoprotein E ε4 (APOE-ε4) genotype is the strongest common genetic determinant of Alzheimer's disease (AD). The pleiotropic nature of apolipoprotein E has made elucidation of the aetiological basis difficult to establish, which is further complicated by the fact that the penetrance of the APOE-ε4 allele is modulated by sex, age, and nutrition. A greater metabolic consequence of the APOE-ε4 allele is likely to contribute to the fact that two-thirds of AD patients are female. A higher tissue status of the marine n-3 fatty acid docosahexaenoic acid (DHA) is associated with a lower AD risk...
May 21, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29896105/anti-neuroinflammatory-potential-of-natural-products-in-attenuation-of-alzheimer-s-disease
#2
REVIEW
Bushra Shal, Wei Ding, Hussain Ali, Yeong S Kim, Salman Khan
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder associated with dementia and cognitive impairment most common in elderly population. Various pathophysiological mechanisms have been proposed by numerous researcher, although, exact mechanism is not yet elucidated. Several studies have been indicated that neuroinflammation associated with deposition of amyloid- beta (Aβ) in brain is a major hallmark toward the pathology of neurodegenerative diseases. So, there is a need to unravel the link of inflammatory process in neurodegeneration...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29870270/impact-of-gut-microbiota-on-neurological-diseases-diet-composition-and-novel-treatments
#3
Ana Larroya-García, Diana Navas-Carrillo, Esteban Orenes-Piñero
Gut microbiota has significant effects on the structure and function of the enteric and central nervous system including human behaviour and brain regulation. Herein, we analyze the role of this intestinal ecosystem, the effects of dietary changes and the administration of nutritional supplements, such as probiotics, prebiotics, or fecal transplantation in neuropsychiatric disorders. Numerous factors have been highlighted to influence gut microbiota composition, including genetics, health status, mode of birth delivery and environment...
June 5, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29867444/brain-distribution-and-modulation-of-neuronal-excitability-by-indicaxanthin-from-opuntia-ficus-indica-administered-at-nutritionally-relevant-amounts
#4
Giuditta Gambino, Mario Allegra, Pierangelo Sardo, Alessandro Attanzio, Luisa Tesoriere, Maria A Livrea, Giuseppe Ferraro, Fabio Carletti
Several studies have recently investigated the role of nutraceuticals in complex pathophysiological processes such as oxidative damages, inflammatory conditions and excitotoxicity. In this regard, the effects of nutraceuticals on basic functions of neuronal cells, such as excitability, are still poorly investigated. For this reason, the possible modulation of neuronal excitability by phytochemicals (PhC) could represent an interesting field of research given that excitotoxicity phenomena are involved in neurodegenerative alterations leading, for example, to Alzheimer's disease...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29846084/neuro-nutrients-as-anti-alzheimer-s-disease-agents-a-critical-review
#5
Sunil K Ravi, Ramesh B Narasingappa, Bruno Vincent
Alzheimer's disease (AD) is characterized by a massive neuronal death causing memory loss, cognitive impairment and behavioral alteration that ultimately lead to dementia and death. AD is a multi-factorial pathology controlled by molecular events such as oxidative stress, protein aggregation, mitochondrial dysfunction and neuro inflammation. Nowadays, there is no efficient disease-modifying treatment for AD and epidemiological studies have suggested that diet and nutrition have a significant impact on the development of this disorder...
May 30, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29808955/factors-affecting-the-appetites-of-persons-with-alzheimer-s-disease-and-mild-cognitive-impairment
#6
Shino Suma, Yutaka Watanabe, Hirohiko Hirano, Ai Kimura, Ayako Edahiro, Shuichi Awata, Yoshihisa Yamashita, Kenji Matsushita, Hidenori Arai, Takashi Sakurai
AIM: Appetite loss has been associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Among older people, decreased appetite can result in poor nutrition and subsequent loss of independent living. We examined the factors related to appetite loss in persons with AD and MCI to provide evidence for countermeasures to prevent appetite loss and progression of cognitive impairment. METHODS: We included 1238 older adults undergoing outpatient treatment at the Center for Comprehensive Care and Research on Memory Disorders (Medical Center for Dementia) at the National Center for Geriatrics and Gerontology in Obu, Japan...
May 29, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29783682/heat-shock-gene-inactivation-and-protein-aggregation-with-links-to-chronic-diseases
#7
Ian James Martins
The heat shock response involved in protein misfolding is linked to the formation of toxic immunogenic proteins with heat shock proteins (HSP) as regulators of amyloid beta aggregation. The defective amyloid beta trafficking between different intracellular compartments is now relevant to HSPs and autoimmunity. Overnutrition, temperature dysregulation, and stress repress the heat shock gene Sirtuin 1 with the induction of HSP regulated amyloid beta aggregation involved in the autoimmune response. Defective circadian rhythm alterations are connected to inactivation of the peripheral sink amyloid beta clearance pathway and related to insulin resistance, protein aggregation, and autoimmune disease in non-alcoholic fatty liver disease (NAFLD) and various neurodegenerative diseases such as Alzheimer's disease...
May 18, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29768349/comparison-of-multiple-interventions-for-older-adults-with-alzheimer-disease-or-mild-cognitive-impairment-a-prisma-compliant-network-meta-analysis
#8
Jing-Hong Liang, Yong Xu, Lu Lin, Rui-Xia Jia, Hong-Bo Zhang, Lei Hang
BACKGROUND: The increasing prevalence of Alzheimer disease (AD) emphasizes the need for effective treatments. Both pharmacological therapies such as nutrition therapy (NT) and nonpharmacologic therapies including traditional treatment or personalized treatment (e.g., physical exercise, music therapy, computerized cognitive training) have been approved for the treatment of AD or mild cognitive impairment (MCI) in numerous areas. METHODS: The aim of this study was to compare 4 types of interventions, physical exercise (PE), music therapy (MT), computerized cognitive training (CCT), and NT, in older adults with mild to moderate AD or MCI and identify the most effective intervention for their cognitive function...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29764286/environmental-evaluation-of-flocculation-efficiency-in-the-separation-of-the-microalgal-biomass-of-scenedesmus-sp-cultivated-in-full-scale-photobioreactors
#9
Marisa D Scherer, Fernando J C Magalhães Filho, Amanda C Oliveira, Nelson F H Selesu, Cássia M L Ugaya, André B Mariano, José V C Vargas
In this paper the environmental evaluation of the separation process of the microalgal biomass Scenedesmus sp. from full-scale photobioreactors was carried out at the Research and Development Nucleus for Sustainable Energy (NPDEAS), with different flocculants (iron sulfate - FeCl3 , sodium hydroxide - NaOH, calcium hydroxide - Ca(OH)2 and aluminum sulphate Al2 (SO4 )3 , by means of the life cycle assessment (LCA) methodology, using the SimaPro 7.3 software. Furthermore, the flocculation efficiency by means of optical density (OD) was also evaluated...
May 15, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29751506/neurocognitive-disorders-and-dehydration-in-older-patients-clinical-experience-supports-the-hydromolecular-hypothesis-of-dementia
#10
Michele Lauriola, Antonio Mangiacotti, Grazia D'Onofrio, Leandro Cascavilla, Francesco Paris, Giulia Paroni, Davide Seripa, Antonio Greco, Daniele Sancarlo
Abnormalities of water homeostasis can be early expressions of neuronal dysfunction, brain atrophy, chronic cerebrovasculopathy and neurodegenerative disease. The aim of this study was to analyze the serum osmolality of subjects with cognitive impairment. One thousand and ninety-one consecutive patients attending the Alzheimer’s Evaluation Unit were evaluated with the Mini-Mental State Examination (MMSE), 21-Item Hamilton Depression Rating Scale (HDRS-21), Activities of Daily Living (ADL), Instrumental-ADL (IADL), Mini Nutritional Assessment (MNA), Exton-Smith Scale (ESS), and Cumulative Illness Rating Scale (CIRS)...
May 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29749754/predictors-of-mortality-during-hospitalization-and-3-months-after-discharge-in-elderly-people-with-and-without-dementia
#11
Josune Martín, Angel Padierna, Ane Anton-Ladislao, Inmaculada Moro, José M Quintana
OBJECTIVES: The aims of this study were to assess mortality during hospitalization and 3 months after discharge in elderly people with and without dementia, and to identify variables that might predict mortality. METHODS: A prospective matched cohort study was conducted involving 195 inpatients with dementia and 204 inpatients without dementia. Information on sociodemographic, and clinical data were gathered. Patients completed questionnaires on premorbid basic (Barthel, BI) and instrumental activities of daily living (Lawton and Brody), quality of life (EuroQoL5-D; Quality of Life in Alzheimer's Disease), burden of the caregiver (Zarit)...
May 11, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29748034/ampk-induced-memory-improvements-in-the-diabetic-population-a-case-study
#12
Alicia Halikas, Kelly J Gibas
Diabetics in mid-life carry a 1.5 times higher risk of developing Alzheimer's disease than those diagnosed with diabetes (T2D) later in life [1]. Recent research points to accelerated cognitive decline within a range of 20%-50% for middle-aged diabetics as compared to non-diabetic populations [2,3]. Metabolic syndrome (MetS), a type 2 diabetes (T2D) precursor, is also linked to MCI and AD pathologies via hypo-metabolic brain circuitry that inhibits glucose metabolism and attenuates cognitive function [4]. Dysregulation of intracellular and extracellular signaling as mediated by the mTOR and AMPK pathways is the result...
April 27, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29743650/the-transition-to-modernity-and-chronic-disease-mismatch-and-natural-selection
#13
REVIEW
Stephen Corbett, Alexandre Courtiol, Virpi Lummaa, Jacob Moorad, Stephen Stearns
The Industrial Revolution and the accompanying nutritional, epidemiological and demographic transitions have profoundly changed human ecology and biology, leading to major shifts in life history traits, which include age and size at maturity, age-specific fertility and lifespan. Mismatch between past adaptations and the current environment means that gene variants linked to higher fitness in the past may now, through antagonistic pleiotropic effects, predispose post-transition populations to non-communicable diseases, such as Alzheimer disease, cancer and coronary artery disease...
May 9, 2018: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/29714994/issues-in-geriatric-care-alzheimer-disease
#14
Kathy Kemle, Richard J Ackermann
Alzheimer disease (AD) occurs in 8.8% of older US adults and is the sixth leading cause of death among older adults. Medicare annual wellness visits require screening for cognitive impairment but do not specify screening methods. Numerous screening instruments are available. If results are positive, evaluation with well-validated assessment tools is needed. If cognitive impairment is confirmed, laboratory tests and imaging studies should be obtained to rule out reversible etiologies. If patients meet diagnostic criteria for AD, clinicians should educate patients and families on the expected course and help them complete advance directives...
May 2018: FP Essentials
https://www.readbyqxmd.com/read/29704994/%C3%AE-h2ax-is-increased-in-peripheral-blood-lymphocytes-of-alzheimer-s-disease-patients-in-the-south-australian-neurodegeneration-nutrition-and-dna-damage-sand-study-of-aging
#15
Mohammad Sabbir Siddiqui, Maxime Francois, Jane Hecker, Jeffrey Faunt, Michael F Fenech, Wayne R Leifert
An early cellular response to DNA double-strand breaks is the phosphorylation of histone H2AX to form γH2AX. Although increased levels of γH2AX have been reported in neuronal nuclei of Alzheimer's disease (AD) patients, γH2AX responses in the lymphocytes of individuals with mild cognitive impairment (MCI) and AD remain unexplored. In this study, the endogenous γH2AX level was measured, using laser scanning cytometry (LSC) and visual scoring, in lymphocyte nuclei from MCI (n = 18), or AD (n = 20) patients and healthy controls (n = 40)...
May 2018: Mutation Research
https://www.readbyqxmd.com/read/29678606/ketogenic-diet-high-intensity-interval-training-hiit-and-memory-training-in-the-treatment-of-mild-cognitive-impairment-a-case-study
#16
Kaitlyn Dahlgren, Kelly J Gibas
Alzheimer's disease (AD) deaths have increased by 89% since 2000. This alarming trajectory of neurological disease highlights the failure of current best practice. Deteriorating brain fuel supply is the nemesis of intact neurological health. Cerebral hypo-metabolism associated with AD occurs years before onset. Both the ketogenic diet and calorie restriction (fasting) lead to a compensatory rise in ketones to improve energy deficits in the brain derived from cerebral insulin resistance. Two forms of ketone bodies, β-hydroxybutyrate and acetoacetate, fuel the brain during starvation, fasting and strenuous exercise...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29616974/assessment-of-nutritional-status-and-conformity-with-mediterranean-diet-of-family-caregivers-of-alzheimer-s-disease-patients
#17
Anna Chalkiadaki, Georgia Stefanoudaki, Anastasia Markaki
No abstract text is available yet for this article.
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29608860/eckmaxol-a-phlorotannin-extracted-from-ecklonia-maxima-produces-anti-%C3%AE-amyloid-oligomer-neuroprotective-effects-possibly-via-directly-acting-on-glycogen-synthase-kinase-3%C3%AE
#18
Jialing Wang, Jiachen Zheng, Chunhui Huang, Jiaying Zhao, Jiajia Lin, Xuezhen Zhou, C Benjamin Naman, Ning Wang, William H Gerwick, Qinwen Wang, Xiaojun Yan, Wei Cui, Shan He
Alzheimer's disease is a progressive neurodegenerative disorder that mainly affects the elderly. Soluble β-amyloid oligomer, which can induce neurotoxicity, is generally regarded as the main neurotoxin in Alzheimer's disease. Here we report that eckmaxol, a phlorotannin extracted from the brown alga Ecklonia maxima, could produce neuroprotective effects in SH-SY5Y cells. Eckmaxol effectively prevented but did not rescue β-amyloid oligomer-induced neuronal apoptosis and increase of intracellular reactive oxygen species...
April 10, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29587223/hallmarks-of-alzheimer-disease-are-evolving-relentlessly-in-metropolitan-mexico-city-infants-children-and-young-adults-apoe4-carriers-have-higher-suicide-risk-and-higher-odds-of-reaching-nft-stage-v-at-%C3%A2-40-years-of-age
#19
Lilian Calderón-Garcidueñas, Angélica Gónzalez-Maciel, Rafael Reynoso-Robles, Ricardo Delgado-Chávez, Partha S Mukherjee, Randy J Kulesza, Ricardo Torres-Jardón, José Ávila-Ramírez, Rodolfo Villarreal-Ríos
Exposures to fine particulate matter (PM2.5 ) and ozone (O3 ) above USEPA standards are associated with Alzheimer's disease (AD) risk. Metropolitan Mexico City (MMC) residents have life time exposures to PM2.5 and O3 above USEPA standards. We investigated AD intra and extracellular protein aggregates and ultrastructural neurovascular pathology in 203 MMC residents age 25.36 ± 9.23 y. Immunohistochemical methods were used to identify AT8 hyperphosphorilated tau (Htau) and 4G8 (amyloid β 17-24). Primary outcomes: staging of Htau and amyloid, per decade and cumulative PM2...
July 2018: Environmental Research
https://www.readbyqxmd.com/read/29566595/15-year-secular-trends-in-cognitive-function-among-older-adults-in-the-united-states
#20
Emily Frith, Paul D Loprinzi
Cognitive impairment is associated with various chronic diseases, including mobility limitation and early mortality. Thus, evaluating changes in cognition is of paramount public health interest. The purpose of this study was to evaluate secular trends in cognitive function among a representative sample of the U.S. older adult population. Data from the 1999-2000, 2001-2002, 2011-2012, and 2013-2014 National Health and Nutrition Examination Survey were utilized to identify an aggregate sample of adults 60+ years of age...
January 1, 2018: Psychological Reports
keyword
keyword
19388
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"