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Alzheimers and nutrition

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https://www.readbyqxmd.com/read/28446028/impact-of-nutritional-supplementation-and-a-psychomotor-program-on-patients-with-alzheimer-s-disease
#1
Odete Vicente de Sousa, Rita Soares Guerra, Ana Sofia Sousa, Bebiana Pais Henriques, Anabela Pereira Monteiro, Teresa Freitas Amaral
This study aims to evaluate the impact of oral nutritional supplementation (ONS) and a psychomotor rehabilitation program on nutritional and functional status of community-dwelling patients with Alzheimer's disease (AD). A 21-day prospective randomized controlled trial was conducted and third intervention group performed a psychomotor rehabilitation program. Patients were followed up for 180 days. Mean (standard deviation) score of Mini Nutritional Assessment (MNA) increased both in the nutritional supplementation group (NSG; n = 25), 0...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28442284/fitness-fatness-index-and-alzheimer-specific-mortality
#2
Emily Frith, Paul D Loprinzi
OBJECTIVE: We evaluated the specific association between a Fitness Fat Index (FFI) and Alzheimer's-specific mortality among a national sample of the broader U.S. adult population. METHODS: FFI was calculated as cardiorespiratory fitness (CRF) divided by waist-to-height ratio (WHR). Data from the 1999-2006 National Health and Nutrition Examination Survey (NHANES) were used to identify 16,146 participants, ages 20-85. Data from participants in these cycles were linked to death certificate data from the National Death Index...
April 22, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28436191/hospitalization-and-associated-factors-in-people-with-alzheimer-s-disease-residing-in-a-long-term-care-facility-in-southern-taiwan
#3
Chu-Sheng Lin, Shih-Yi Lin, Ming-Yueh Chou, Liang-Yu Chen, Kuei-Yu Wang, Liang-Kung Chen, Yu-Te Lin, Ching-Hui Loh
AIM: It has been reported that many people with dementia require hospitalizations. The objective of the present study was to determine predictive factors for hospitalizations in people with dementia. METHODS: A total of 70 individuals with dementia living in a veterans' home in southern Taiwan were consecutively enrolled. During prospective follow up, all hospitalization events were recorded. RESULTS: The mean age of residents with dementia was 86...
April 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28410120/snp_tata_comparator-genomewide-landmarks-for-preventive-personalized-medicine
#4
Mikhail Ponomarenko, Dmitry Rasskazov, Irina Chadaeva, Ekaterina Sharypova, Petr Ponomarenko, Olga Arkova, Elena Kashina, Nikita Ivanisenko, Dmitry Zhechev, Ludmila Savinkova, Nikolay Kolchanov
Year after year, conditions, quality, and duration of human lives have been improving due to the progress of science, technology, education, and medicine, which however has a downside. Owing to improvement in children's nutrition, developmental acceleration occurs that imbalances a child's system. Because of virtual worlds of the Internet, social experience of teenagers expands and clashes with puberty of adolescents. Due to the comfort of cities, urbanization emerges and causes stress to adults because of artificial light, noise, pollution, violations of personal space, and family disruption...
June 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28359749/effect-of-long-term-omega-3-polyunsaturated-fatty-acid-supplementation-with-or-without-multidomain-intervention-on-cognitive-function-in-elderly-adults-with-memory-complaints-mapt-a-randomised-placebo-controlled-trial
#5
RANDOMIZED CONTROLLED TRIAL
Sandrine Andrieu, Sophie Guyonnet, Nicola Coley, Christelle Cantet, Marc Bonnefoy, Serge Bordes, Lawrence Bories, Marie-Noëlle Cufi, Thierry Dantoine, Jean-François Dartigues, Françoise Desclaux, Audrey Gabelle, Yannick Gasnier, Alain Pesce, Kristel Sudres, Jacques Touchon, Philippe Robert, Olivier Rouaud, Philippe Legrand, Pierre Payoux, Jean-Paul Caubere, Michael Weiner, Isabelle Carrié, Pierre-Jean Ousset, Bruno Vellas
BACKGROUND: No large trials have been done to investigate the efficacy of an intervention combining a specific compound and several lifestyle interventions compared with placebo for the prevention of cognitive decline. We tested the effect of omega 3 polyunsaturated fatty acid supplementation and a multidomain intervention (physical activity, cognitive training, and nutritional advice), alone or in combination, compared with placebo, on cognitive decline. METHODS: The Multidomain Alzheimer Preventive Trial was a 3-year, multicentre, randomised, placebo-controlled superiority trial with four parallel groups at 13 memory centres in France and Monaco...
May 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28317485/defective-insulin-signalling-mediated-by-inflammation-connects-obesity-to-alzheimer-disease-relevant-pharmacological-therapies-and-preventive-dietary-interventions
#6
Arantxa Rodriguez-Casado, Adolfo Toledano-Díaz, Adolfo Toledano
Recent evidence suggests that obesity, besides being a risk factor for cardiovascular events, also increases the risk of Alzheimer's disease. Insulin resistance is common in all cases of obesity and appears to be the linkage between both diseases. Obesity, often associated with excessive fat and sugar intake, represents a preclinical stage toward insulin resistance during which nutrition intervention is likely to have maximum effect. In this way, healthy lifestyles lifetime to prevent obesity-related modifiable risk factors such as inflammation, oxidative stress and metabolic disorders could be simultaneously beneficial for preserving cognition and controlling the Alzheimer's...
March 16, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28314621/docosahexaenoic-acid-dha-an-essential-nutrient-and-a-nutraceutical-for-brain-health-and-diseases
#7
REVIEW
Grace Y Sun, Agnes Simonyi, Kevin L Fritsche, Dennis Y Chuang, Mark Hannink, Zezong Gu, C Michael Greenlief, Jeffrey K Yao, James C Lee, David Q Beversdorf
Docosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in phospholipids in the brain and retina, is known to play multi-functional roles in brain health and diseases. While arachidonic acid (AA) is released from membrane phospholipids by cytosolic phospholipase A2 (cPLA2), DHA is linked to action of the Ca(2+)-independent iPLA2. DHA undergoes enzymatic conversion by 15-lipoxygenase (Alox 15) to form oxylipins including resolvins and neuroprotectins, which are powerful lipid mediators. DHA can also undergo non-enzymatic conversion by reacting with oxygen free radicals (ROS), which cause the production of 4-hydoxyhexenal (4-HHE), an aldehyde derivative which can form adducts with DNA, proteins and lipids...
March 10, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28303161/a-systematic-review-of-intervention-studies-examining-nutritional-and-herbal-therapies-for-mild-cognitive-impairment-and-dementia-using-neuroimaging-methods-study-characteristics-and-intervention-efficacy
#8
REVIEW
Genevieve Z Steiner, Danielle C Mathersul, Freya MacMillan, David A Camfield, Nerida L Klupp, Sai W Seto, Yong Huang, Mark I Hohenberg, Dennis H Chang
Neuroimaging facilitates the assessment of complementary medicines (CMs) by providing a noninvasive insight into their mechanisms of action in the human brain. This is important for identifying the potential treatment options for target disease cohorts with complex pathophysiologies. The aim of this systematic review was to evaluate study characteristics, intervention efficacy, and the structural and functional neuroimaging methods used in research assessing nutritional and herbal medicines for mild cognitive impairment (MCI) and dementia...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28298276/early-life-nutritional-programming-of-cognition-the-fundamental-role-of-epigenetic-mechanisms-in-mediating-the-relation-between-early-life-environment-and-learning-and-memory-process
#9
REVIEW
Laura Moody, Hong Chen, Yuan-Xiang Pan
The perinatal period is a window of heightened plasticity that lays the groundwork for future anatomic, physiologic, and behavioral outcomes. During this time, maternal diet plays a pivotal role in the maturation of vital organs and the establishment of neuronal connections. However, when perinatal nutrition is either lacking in specific micro- and macronutrients or overloaded with excess calories, the consequences can be devastating and long lasting. The brain is particularly sensitive to perinatal insults, with several neurologic and psychiatric disorders having been linked to a poor in utero environment...
March 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28236606/physical-function-differences-between-the-stages-from-normal-cognition-to-moderate-alzheimer-disease
#10
Chisato Fujisawa, Hiroyuki Umegaki, Kazushi Okamoto, Hirotaka Nakashima, Masafumi Kuzuya, Kenji Toba, Takashi Sakurai
OBJECTIVES: We investigated the differences in the physical function test results across stages from normal cognition (NC) to moderate Alzheimer disease (AD) and how risk factors of physical function decline are correlated with the physical function test results. DESIGN: A cross-sectional study of outpatients at the Memory Disorder Outpatient Center of Japan's National Center of Geriatrics and Gerontology. PARTICIPANTS: We enrolled 882 individuals aged ≥65 diagnosed with NC (n = 210), amnestic mild cognitive impairment (aMCI; n = 273), mild AD (n = 181) or moderate AD (n = 197)...
April 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28187148/nutritional-status-and-body-composition-by-bioelectrical-impedance-vector-analysis-a-cross-sectional-study-in-mild-cognitive-impairment-and-alzheimer-s-disease
#11
Ilaria Cova, Simone Pomati, Laura Maggiore, Marica Forcella, Valentina Cucumo, Roberta Ghiretti, Giulia Grande, Fulvio Muzio, Claudio Mariani
AIMS: Analysis of nutritional status and body composition in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). METHODS: A cross-sectional study was performed in a University-Hospital setting, recruiting 59 patients with AD, 34 subjects with MCI and 58 elderly healthy controls (HC). Nutritional status was assessed by anthropometric parameters (body mass index; calf, upper arm and waist circumferences), Mini Nutritional Assessment (MNA) and body composition by bioelectrical impedance vector analysis (BIVA)...
2017: PloS One
https://www.readbyqxmd.com/read/28176624/vitamin-d-combined-with-resveratrol-prevents-cognitive-decline-in-samp8-mice
#12
Jinbo Cheng, Yehua Rui, Liqiang Qin, Jiaying Xu, Shufen Han, Linxi Yuan, Xuebin Yin, Zhongxiao Wan
Background Vitamin D (VD) and resveratrol (RSV) are two nutritional molecules that have reported neuroprotective effects, and findings from cellular models suggest that resveratrol could potentiate vitamin D's effects. The senescence-accelerated mouse-prone 8 (SAMP8) is a useful model of Alzheimer's disease (AD)-related memory impairment. Objective We aimed to explore how the combination of vitamin D with resveratrol would affect memory impairments shown by SAMP8 mice, as well as the potential mechanisms...
February 6, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28168012/nutrition-and-age-ing-focusing-on-alzheimer-s-disease
#13
REVIEW
Giulia Abate, Mariagrazia Marziano, Wiramon Rungratanawanich, Maurizio Memo, Daniela Uberti
Recently, the role of food and nutrition in preventing or delaying chronic disability in the elderly population has received great attention. Thanks to their ability to influence biochemical and biological processes, bioactive nutrients are considered modifiable factors capable of preserving a healthy brain status. A diet rich in vitamins and polyphenols and poor in saturated fatty acids has been recommended. In the prospective of a healthy diet, cooking methods should be also considered. In fact, cooking procedures can modify the original dietary content, contributing not only to the loss of healthy nutrients, but also to the formation of toxins, including advanced glycation end products (AGEs)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28167456/antidepressant-and-anxiolytic-like-activity-of-sodium-selenite-after-acute-treatment-in-mice
#14
Ewa Kędzierska, Jarosław Dudka, Ewa Poleszak, Jolanta H Kotlińska
BACKGROUND: Selenium (Se) is an essential trace element for humans and animals, that is needed for a broad variety of physiological functions including thyroid hormone metabolism, protection against oxidative stress, and immunity associated functions. Human nutritional Se deficiencies are associated with neuropsychiatric diseases, like Alzheimer's disease, Parkinson's disease, obsessive - compulsive disorder, stroke, epilepsy as well as depressive behaviours. In this study we examined antidepressant- and anxiolytic-like activity of Se in the inorganic form of sodium selenite and investigated whether Se influence on the locomotor activity in mice...
April 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28165366/lychee-seed-saponins-improve-cognitive-function-and-prevent-neuronal-injury-via-inhibiting-neuronal-apoptosis-in-a-rat-model-of-alzheimer-s-disease
#15
Xiuling Wang, Jianming Wu, Chonglin Yu, Yong Tang, Jian Liu, Haixia Chen, Bingjin Jin, Qibing Mei, Shousong Cao, Dalian Qin
Lychee seed is a traditional Chinese medicine and possesses many activities, including hypoglycemia, liver protection, antioxidation, antivirus, and antitumor. However, its effect on neuroprotection is still unclear. The present study investigated the effects of lychee seed saponins (LSS) on neuroprotection and associated mechanisms. We established a rat model of Alzheimer's disease (AD) by injecting Aβ25-35 into the lateral ventricle of rats and evaluated the effect of LSS on spatial learning and memory ability via the Morris water maze...
February 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28157103/mortality-risk-after-diagnosis-of-early-onset-alzheimer-s-disease-versus-late-onset-alzheimer-s-disease-a-propensity-score-matching-analysis
#16
Ki Jung Chang, Chang Hyung Hong, Kang Soo Lee, Dae Ryong Kang, Jeong Dong Lee, Seong Hye Choi, Seong Yoon Kim, Duk L Na, Sang Won Seo, Do-Kwan Kim, Yunhwan Lee, Young Ki Chung, Ki Young Lim, Jai Sung Noh, Jungsik Park, Sang Joon Son
BACKGROUND/OBJECTIVE: We aimed to compare the risk of mortality in patients with early-onset Alzheimer's disease (EOAD) versus those with late-onset AD (LOAD) using a large number of study subjects. We applied propensity score matching (PSM) to minimize confounding biases in the comparison between EOAD and LOAD. METHODS: We obtained data from elderly Korean subjects with AD (n = 3,611) at baseline from the CREDOS cohort study, which was conducted from November 2005 to July 2013...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28154522/metal-dyshomeostasis-and-their-pathological-role-in-prion-and-prion-like-diseases-the-basis-for-a-nutritional-approach
#17
REVIEW
Mattia Toni, Maria L Massimino, Agnese De Mario, Elisa Angiulli, Enzo Spisni
Metal ions are key elements in organisms' life acting like cofactors of many enzymes but they can also be potentially dangerous for the cell participating in redox reactions that lead to the formation of reactive oxygen species (ROS). Any factor inducing or limiting a metal dyshomeostasis, ROS production and cell injury may contribute to the onset of neurodegenerative diseases or play a neuroprotective action. Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of fatal neurodegenerative disorders affecting the central nervous system (CNS) of human and other mammalian species...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28146152/review-on-cell-models-to-evaluate-the-potential-antioxidant-activity-of-polysaccharides
#18
REVIEW
Zhi-Jun Wang, Jian-Hua Xie, Shao-Ping Nie, Ming-Yong Xie
Owing to various health functions, natural polysaccharides are becoming a kind of popular dietary nutritional supplement. At present, the occurrence of many chronic diseases is closely related to excessive reactive oxygen species (ROS). Note that polysaccharides with anti-oxidative activity have been paid significant attention as medicines, cosmetics, and food. Many documents constantly prove the effects of antioxidant polysaccharides against Alzheimer's disease, diabetes, and cardiovascular disease. Moreover, the structural features and functional properties of antioxidant polysaccharides have been extensively studied...
February 1, 2017: Food & Function
https://www.readbyqxmd.com/read/28131190/comorbid-conditions-associated-with-parkinson-s-disease-a-longitudinal-and-comparative-study-with-alzheimer-disease-and-control-subjects
#19
D Santos García, E Suárez Castro, I Expósito, T de Deus, C Tuñas, A Aneiros, M López Fernández, D Núñez Arias, M Bermúdez Torres
BACKGROUND AND OBJECTIVE: To study what comorbid conditions were present at baseline and 3years later in a cohort of Spanish Parkinson's disease (PD) patients, to compare comorbidity with both Alzheimer's disease (AD) and control groups and to analyze the role of comorbidity as predictor of mortality. METHODS: One hundred and forty-seven non-demented PD patients (57.1% males; 70.9±8.6years old) were included in this 36months follow-up (2012-2015), monocenter, evaluation study...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28112351/nonpharmacological-strategies-for-patients-with-early-stage-dementia-or-mild-cognitive-impairment-a-10-year-update
#20
Joel G Anderson, Ruth Palan Lopez, Karen M Rose, Janet K Specht
As the incidence and prevalence of early-stage Alzheimer's disease and mild cognitive impairment increases worldwide, gerontological researchers continue to examine the efficacy and effectiveness of strategies to help patients and caregivers live with the disease. Although pharmacological treatments remain the focus of much of the research, nonpharmacological strategies and approaches to care continue to gain ground as effective means of improving the health-related quality of life for this patient population...
January 1, 2017: Research in Gerontological Nursing
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