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Alzheimers and nutrition

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https://www.readbyqxmd.com/read/29037152/low-plasma-tryptophan-is-associated-with-olfactory-function-in-healthy-elderly-community-dwellers-in-japan
#1
Yusuke Adachi, Yoshiki Shimodaira, Hidehiro Nakamura, Akira Imaizumi, Maiko Mori, Yoko Kageyama, Yasushi Noguchi, Asuka Seki, Yuki Okabe, Yuko Miyake, Kaori Ono, Shu Kumagai
BACKGROUND: Decreased circulating tryptophan (Trp) levels are frequently observed in elderly patients with neurodegenerative disease including Alzheimer's disease. Trp may serve as a potential biomarker for monitoring disease risk in elderly people. We aimed to investigate the association between low plasma Trp levels and olfactory function, which is known to predict age-related diseases including dementia in elderly people. METHODS: A total of 144 healthy elderly Japanese community (≥ 65 years old) dwellers from the Health, Aging and Nutritional Improvement study (HANI study) were the subjects of our analysis...
October 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29035971/dietary-patterns-and-cognition-in-older-persons
#2
Angela M Abbatecola, Marcello Russo, Michelangela Barbieri
PURPOSE OF REVIEW: The current article reviews recently published evidence of the important role that specific dietary patterns may hold on preventing cognitive impairment and dementia over aging. RECENT FINDINGS: Specific dietary patterns attributed to targeting cardiovascular risk factors may protect against the development of mild cognitive impairment (MCI) and dementia, especially Alzheimer's disease. Numerous epidemiological studies have strongly suggested that multinutrient approaches using the Mediterranean diet (Med diet), dietary approach to systolic hypertension (DASH) and the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) are associated with a lower risk of cognitive impairment, MCI and Alzheimer's disease in older persons...
October 14, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28973985/s-adenosylmethionine-and-superoxide-dismutase-1-synergistically-counteract-alzheimer-s-disease-features-progression-in-tgcrnd8-mice
#3
Rosaria A Cavallaro, Vincenzina Nicolia, Maria Teresa Fiorenza, Sigfrido Scarpa, Andrea Fuso
Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer's Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated by one-carbon metabolism, leading to increased amyloid production. We have also demonstrated that S-adenosylmethionine (SAM) supplementation contrasted the AD-like features, induced by B-vitamin deficiency. In the present study, we expanded these observations by investigating the effects of SAM and SOD (Superoxide dismutase) association...
September 30, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28949318/psychogeriatric-diagnoses-in-old-people-s-homes-and-negative-health-behavior
#4
Spomenka Tomek-Roksandić, Ivana Popek, Nada Tomasović Mrčela, Zvonimir Šostar, Branko Kolarić, Nina Smolej Narančić, Ana Stavljenić Rukavina, Mate Ljubičić
BACKGROUND: The study was designed as a gerontologic-public health analysis of the relationship between the leading and accompanying psychogeriatric diagnoses and negative health behaviors recorded in the old people's home users, with the aim to evaluate and redefine gerontologic-public health priorities and geroprophylactic measures, with special reference to persons suffering from Alzheimer's disease and other dementias. SUBJECT AND METHODS: Gerontologic-public health indicators obtained by monitoring health care needs of the elderly in specific institutional primary health care at 10 old people's homes (N=1185) in Croatia in 2013 were analyzed using the professional methodology developed at Department of Health Gerontology, Andrija Štampar Teaching Institute of Public Health (Registry List 1 that refers to monitoring specific primary health care needs of elderly at old people's homes)...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28936398/vitamin-d-is-associated-with-severity-and-mortality-of-non-alcoholic-fatty-liver-disease-a-us-population-based-study
#5
Hyun-Seok Kim, Laura Rotundo, Neil Kothari, Sung-Hoon Kim, Nikolaos Pyrsopoulos
Background and Aims: There has been increasing evidence that vitamin D deficiency may increase the risk of metabolic syndrome. Since metabolic syndrome is a major risk factor for non-alcoholic fatty liver disease (NAFLD), we aimed to investigate the association between vitamin D and the severity and mortality of NAFLD. Methods: Data was obtained from the United States Third National Health and Nutrition Examination Survey conducted in 1988-1994, with follow-up mortality data through 2011. NAFLD was defined by ultrasonographic detection of hepatic steatosis in the absence of other liver diseases and categorized as normal, mild, moderate or severe...
September 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28929899/nutrition-as-a-component-of-dementia-risk-reduction-strategies
#6
Carol E Greenwood, Matthew D Parrott
According to the Alzheimer Society of Canada, within the next generation, Canada will experience a more than doubling of individuals living with dementia and a potentially economically crippling 10-fold increase in costs to Canadians. Up to 50% of cases with dementia can be attributed to seven modifiable, predominantly vascular and/or lifestyle-associated, risk factors. Multi-modal dementia risk reduction strategies, targeting diet, exercise, mental stimulation, and vascular risk monitoring, are likely to be the most successful...
January 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28911536/biopharmaceutical-potentials-of-prosopis-spp-mimosaceae-leguminosa
#7
REVIEW
Santhaseelan Henciya, Prabha Seturaman, Arthur Rathinam James, Yi-Hong Tsai, Rahul Nikam, Yang-Chang Wu, Hans-Uwe Dahms, Fang Rong Chang
Prosopis is a commercially important plant genus, which has been used since ancient times, particularly for medicinal purposes. Traditionally, Paste, gum, and smoke from leaves and pods are applied for anticancer, antidiabetic, anti-inflammatory, and antimicrobial purposes. Components of Prosopis such as flavonoids, tannins, alkaloids, quinones, or phenolic compounds demonstrate potentials in various biofunctions, such as analgesic, anthelmintic, antibiotic, antiemetic, microbial antioxidant, antimalarial, antiprotozoal, antipustule, and antiulcer activities; enhancement of H(+), K(+), ATPases; oral disinfection; and probiotic and nutritional effects; as well as in other biopharmaceutical applications, such as binding abilities for tablet production...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28885365/therapeutic-efficacy-of-neuromuscular-electrical-stimulation-and-electromyographic-biofeedback-on-alzheimer-s-disease-patients-with-dysphagia
#8
Yi Tang, Xiang Lin, Xiao-Juan Lin, Wei Zheng, Zhi-Kai Zheng, Zhao-Min Lin, Jian-Hao Chen
To study the therapeutic effect of neuromuscular electrical stimulation and electromyographic biofeedback (EMG-biofeedback) therapy in improving swallowing function of Alzheimer's disease patients with dysphagia.A series of 103 Alzheimer's disease patients with dysphagia were divided into 2 groups, among which the control group (n = 50) received swallowing function training and the treatment group (n = 53) received neuromuscular electrical stimulation plus EMG-biofeedback therapy. The mini-mental state scale score was performed in all patients along the treatment period...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28840052/predictors-of-memory-in-healthy-aging-polyunsaturated-fatty-acid-balance-and-fornix-white-matter-integrity
#9
Marta K Zamroziewicz, Erick J Paul, Chris E Zwilling, Aron K Barbey
Recent evidence demonstrates that age and disease-related decline in cognition depends not only upon degeneration in brain structure and function, but also on dietary intake and nutritional status. Memory, a potential preclinical marker of Alzheimer's disease, is supported by white matter integrity in the brain and dietary patterns high in omega-3 and omega-6 polyunsaturated fatty acids. However, the extent to which memory is supported by specific omega-3 and omega-6 polyunsaturated fatty acids, and the degree to which this relationship is reliant upon microstructure of particular white matter regions is not known...
July 2017: Aging and Disease
https://www.readbyqxmd.com/read/28815739/kernicterus-in-a-boy-with-ornithine-transcarbamylase-deficiency-a-case-report
#10
Eduardo López-Corella, Isabel Ibarra-González, Cynthia Fernández-Lainez, Miguel Á Rodríguez-Weber, Sara Guillén-Lopez, Leticia Belmont-Martínez, David Agüero-Linares, Marcela Vela-Amieva
Ornithine transcarbamylase deficiency (OTCD) is an X-linked urea cycle defect associated with severe and usually fatal hyperammonemia. This study describes a patient with early onset lethal OTCD due to a known pathogenic variant (c.298+1G>A), as well as the novel autopsy finding of kernicterus with relatively low blood concentration of unconjugated bilirubin (UCB) (11.55 mg/dL). The patient was a full-term male with a family history of two previous male siblings who died as newborns after acute neurologic deterioration...
August 16, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28807434/nutritional-strategies-in-the-management-of-alzheimer-disease-systematic-review-with-network-meta-analysis
#11
Shirley Steffany Muñoz Fernández, Terry Ivanauskas, Sandra Maria Lima Ribeiro
BACKGROUND: Alzheimer disease (AD) is the major cause of dependency and disability in the elderly. Numerous studies have sought to achieve its prevention and/or management examining a role for modifiable risk factors, such as nutrition. This work aims to investigate the effects of food and/or nutrients in the management of AD at different stages. METHODS: Electronic databases were searched for clinical trials examining the effect of nutrient intervention in individuals with AD, compared with placebo, published up to 2014...
October 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28690633/how-do-community-dwelling-persons-with-alzheimer-disease-fall-falls-in-the-finalex-study
#12
Niko M Perttila, Hannareeta Öhman, Timo E Strandberg, Hannu Kautiainen, Minna Raivio, Marja-Liisa Laakkonen, Niina Savikko, Reijo S Tilvis, Kaisu H Pitkala
BACKGROUND: People with dementia are at high risk for falls. However, little is known of the features causing falls in Alzheimer disease (AD). Our aim was to investigate how participants with AD fall. METHODS: In the FINALEX (Finnish Alzheimer Disease Exercise Trial) study, participants' (n = 194) falls were followed up for 1 year by diaries kept by their spouses. RESULTS: The most common reason for falls (n = 355) was stumbling (n = 61). Of the falls, 123 led to injuries, 50 to emergency department visits, and 13 to fractures...
May 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28671332/association-between-malnutrition-and-hyperhomocysteine-in-alzheimer-s-disease-patients-and-diet-intervention-of-betaine
#13
Jianying Sun, Shiling Wen, Jing Zhou, Shuling Ding
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease, which is associated with malnutrition and hyperhomocysteine. The current study aimed to analyze the relationship between malnutrition and hyperhomocysteine in AD patients, and effects of diet intervention with betaine on the disease. METHODS: The nutritional statuses of the AD patients were assessed by short form mini nutritional assessment (MNA-SF). The levels of Hcy, tau hyperphosphorylation, synaptic proteins, blood inflammatory factors were measured by enzymatic cycling assay, Western blot and ELISA...
November 7, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28660375/the-combined-effect-of-blackcurrant-powder-and-wholemeal-flours-to-improve-health-promoting-properties-of-cookies
#14
A K M Mofasser Hossain, Margaret A Brennan, Susan L Mason, Xinbo Guo, Charles S Brennan
A diet with high glycaemic index, which causes rapid spikes in blood sugar level, can lead to disorders such as significantly increased risk for type 2 diabetes, cardiovascular disease and obesity. These conditions are also linked to the progression of cognitive decline and neurodegenerative diseases including Alzheimer's disease. Blackcurrant powder (BC) is a rich source of dietary fibre and bioactive compounds. Wholemeal wheat, barley and oat flours contain high amount of fibre. In this study, a model food (cookie) was developed and used to investigate the in vitro glycaemic glucose equivalent and antioxidant activities of the cookies made with three different wholemeal flours (wheat, barley and oat) with different replacement levels (5, 10 and 15%) of blackcurrant powder...
June 28, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28654021/vitamin-c-aging-and-alzheimer-s-disease
#15
REVIEW
Fiammetta Monacelli, Erica Acquarone, Chiara Giannotti, Roberta Borghi, Alessio Nencioni
Accumulating evidence in mice models of accelerated senescence indicates a rescuing role of ascorbic acid in premature aging. Supplementation of ascorbic acid appeared to halt cell growth, oxidative stress, telomere attrition, disorganization of chromatin, and excessive secretion of inflammatory factors, and extend lifespan. Interestingly, ascorbic acid (AA) was also found to positively modulate inflamm-aging and immunosenescence, two hallmarks of biological aging. Moreover, ascorbic acid has been shown to epigenetically regulate genome integrity and stability, indicating a key role of targeted nutrition in healthy aging...
June 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28653034/nutrients-required-for-phospholipid-synthesis-are-lower-in-blood-and-cerebrospinal-fluid-in-mild-cognitive-impairment-and-alzheimer-s-disease-dementia
#16
Nick van Wijk, Rosalinde E R Slot, Flora H Duits, Marieke Strik, Egbert Biesheuvel, John W C Sijben, Marinus A Blankenstein, Jörgen Bierau, Wiesje M van der Flier, Philip Scheltens, Charlotte E Teunissen
INTRODUCTION: Synaptic membrane formation depends on nutrients that fuel metabolic pathways for the synthesis of constituent phospholipids. Consequently, insufficient availability of such nutrients may restrict membrane formation and contribute to synaptic dysfunction in Alzheimer's disease (AD). We assessed whether blood and cerebrospinal fluid (CSF) concentrations of nutrients related to phospholipid synthesis differ among patients with AD, mild cognitive impairment (MCI), and control subjects...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28638339/nutritional-and-pharmacological-strategies-to-regulate-microglial-polarization-in-cognitive-aging-and-alzheimer-s-disease
#17
REVIEW
Emiliano Peña-Altamira, Sabrina Petralla, Francesca Massenzio, Marco Virgili, Maria L Bolognesi, Barbara Monti
The study of microglia, the immune cells of the brain, has experienced a renaissance after the discovery of microglia polarization. In fact, the concept that activated microglia can shift into the M1 pro-inflammatory or M2 neuroprotective phenotypes, depending on brain microenvironment, has completely changed the understanding of microglia in brain aging and neurodegenerative diseases. Microglia polarization is particularly important in aging since an increased inflammatory status of body compartments, including the brain, has been reported in elderly people...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28637354/essential-dietary-bioactive-lipids-in-neuroinflammatory-diseases
#18
M Valeria Catani, Valeria Gasperi, Tiziana Bisogno, Mauro Maccarrone
Under physiological conditions, neurons and glia are in a healthy, redox-balanced environment; when injury perturbs this equilibrium, a neuroinflammatory state is established by activated microglia that triggers pro-inflammatory responses and alters the oxidant/antioxidant balance, thus leading to neuronal loss and neurodegeneration. In neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease, amyothrophic lateral sclerosis, and multiple sclerosis), the brain is in a constitutively self-sustaining cycle of inflammation and oxidative stress that prompts and amplifies brain damage...
June 22, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28598848/synaptic-membrane-synthesis-in-rats-depends-on-dietary-sufficiency-of-vitamin-c-vitamin-e-and-selenium-relevance-for-alzheimer-s-disease
#19
Mehmet Cansev, Mesut Turkyilmaz, John W C Sijben, Cansu Sevinc, Laus M Broersen, Nick van Wijk
Chronic consumption of a diet enriched with nutritional precursors of phospholipids, including uridine and the polyunsaturated fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), was shown previously to enhance levels of brain phospholipids and synaptic proteins in rodents. Vitamin C, vitamin E, and selenium may directly affect the breakdown or synthesis of membrane phospholipids. The present study investigated the necessity of antioxidants for the effectiveness of supplementation with uridine plus DHA and EPA (as fish oil) in rats...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28578584/long-term-dietary-supplementation-with-selenium-enriched-yeast-improves-cognitive-impairment-reverses-synaptic-deficits-and-mitigates-tau-pathology-in-a-triple-transgenic-mouse-model-of-alzheimer-s-disease
#20
Zhong-Hao Zhang, Lei Wen, Qiu-Yan Wu, Chen Chen, Rui Zheng, Qiong Liu, Jia-Zuan Ni, Guo-Li Song
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by multiple histopathological changes in the brain and by impairments in memory and cognitive function. Currently, there is no effective treatment that can halt or reverse the progression of this disease. Here, we explored the effects of 3 months of treatment with selenium-enriched yeast (Se-yeast), which is commonly used as a source of organic selenium (Se) for nutrition, on cognitive dysfunction and neuropathology in the triple transgenic mouse model of AD (3×Tg-AD mice)...
June 21, 2017: Journal of Agricultural and Food Chemistry
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