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Alzheimers and nutrition

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https://www.readbyqxmd.com/read/29616974/assessment-of-nutritional-status-and-conformity-with-mediterranean-diet-of-family-caregivers-of-alzheimer-s-disease-patients
#1
Anna Chalkiadaki, Georgia Stefanoudaki, Anastasia Markaki
No abstract text is available yet for this article.
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29608860/eckmaxol-a-phlorotannin-extracted-from-ecklonia-maxima-produces-anti-%C3%AE-amyloid-oligomer-neuroprotective-effects-possibly-via-directly-acting-on-glycogen-synthase-kinase-3%C3%AE
#2
Jialing Wang, Jiachen Zheng, Chunhui Huang, Jiaying Zhao, Jiajia Lin, Xuezhen Zhou, C Benjamin Naman, Ning Wang, William H Gerwick, Qinwen Wang, Xiaojun Yan, Wei Cui, Shan He
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that mainly affects the elderly. Soluble β-amyloid (Aβ) oligomer, which can induce neurotoxicity, is generally regarded as a main neurotoxin in AD. Here we reported that eckmaxol, a phlorotannin extracted from the brown alga Ecklonia maxima, could produce neuroprotective effects in SH-SY5Y cells. Eckmaxol effectively prevented, but did not rescue, Aβ oligomer-induced neuronal apoptosis and increase of intracellular reactive oxygen species...
April 2, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29587223/hallmarks-of-alzheimer-disease-are-evolving-relentlessly-in-metropolitan-mexico-city-infants-children-and-young-adults-apoe4-carriers-have-higher-suicide-risk-and-higher-odds-of-reaching-nft-stage-v-at-%C3%A2-40-years-of-age
#3
Lilian Calderón-Garcidueñas, Angélica Gónzalez-Maciel, Rafael Reynoso-Robles, Ricardo Delgado-Chávez, Partha S Mukherjee, Randy J Kulesza, Ricardo Torres-Jardón, José Ávila-Ramírez, Rodolfo Villarreal-Ríos
Exposures to fine particulate matter (PM2.5 ) and ozone (O3 ) above USEPA standards are associated with Alzheimer's disease (AD) risk. Metropolitan Mexico City (MMC) residents have life time exposures to PM2.5 and O3 above USEPA standards. We investigated AD intra and extracellular protein aggregates and ultrastructural neurovascular pathology in 203 MMC residents age 25.36 ± 9.23 y. Immunohistochemical methods were used to identify AT8 hyperphosphorilated tau (Htau) and 4G8 (amyloid β 17-24). Primary outcomes: staging of Htau and amyloid, per decade and cumulative PM2...
March 24, 2018: Environmental Research
https://www.readbyqxmd.com/read/29566595/15-year-secular-trends-in-cognitive-function-among-older-adults-in-the-united-states
#4
Emily Frith, Paul D Loprinzi
Cognitive impairment is associated with various chronic diseases, including mobility limitation and early mortality. Thus, evaluating changes in cognition is of paramount public health interest. The purpose of this study was to evaluate secular trends in cognitive function among a representative sample of the U.S. older adult population. Data from the 1999-2000, 2001-2002, 2011-2012, and 2013-2014 National Health and Nutrition Examination Survey were utilized to identify an aggregate sample of adults 60+ years of age...
January 1, 2018: Psychological Reports
https://www.readbyqxmd.com/read/29555333/nutritional-patterns-associated-with-the-maintenance-of-neurocognitive-functions-and-the-risk-of-dementia-and-alzheimer-s-disease-a-focus-on-human-studies
#5
REVIEW
Francesca Pistollato, Ruben Calderón Iglesias, Roberto Ruiz, Silvia Aparicio, Jorge Crespo, Luis Dzul Lopez, Piera Pia Manna, Francesca Giampieri, Maurizio Battino
Ample epidemiological evidence suggests a strong correlation among diet, lifestyle factors and the onset and consolidation of dementia and Alzheimer's disease (AD). It has been demonstrated that AD, diabetes, obesity, insulin resistance, and cardiovascular disease are strongly interconnected pathologies. Preventive strategies and nutritional interventions seem to be promising approaches to delay neurocognitive decline and reduce the risk of AD and other non-psychiatric co-morbidities. In this regard, healthy dietary patterns, characterized by high intake of plant-based foods, probiotics, antioxidants, soy beans, nuts, and omega-3 polyunsaturated fatty acids, and a low intake of saturated fats, animal-derived proteins, and refined sugars, have been shown to decrease the risk of neurocognitive impairments and eventually the onset of AD...
March 16, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29532755/homocysteine-and-hyperhomocysteinaemia
#6
Bozidarka L Zaric, Milan Obradovic, Vladan Bajic, Mohamed A Haidara, Milos Jovanovic, Esma R Isenovic
Homocysteine (Hcy) is thiol group containing the amino acid, which naturally occurs in all humans. Hcy is degraded in the body through two metabolic pathways, while a minor part is excreted through kidneys. The chemical reactions that are necessary for degradation of Hcy require the presence of the folic acid, vitamins B6 and B12. Consequently, the level of the total Hcy in the serum is influenced by the presence or absence of these vitamins. An elevated level of the Hcy, hyperhomocysteinemia (HHcy) and homocystinuria are connected with occlusive artery disease, especially in the brain, the heart, and the kidney, in addition to venous thrombosis, chronic renal failure, megaloblastic anemia, osteoporosis, depression, Alzheimer's disease, pregnancy problems, and others...
March 12, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29509552/effects-of-essential-ad2-supplement-on-blood-acetaldehyde-levels-in-individuals-who-have-aldehyde-dehydrogenase-aldh2-deficiency
#7
Ken Fujioka, Spencer Gordon
BACKGROUND: It is estimated that 1 billion people in the world have a point mutation in the gene encoding the aldehyde dehydrogenase 2 (ALDH2) enzyme, the primary enzyme responsible for the metabolism of acetaldehyde. The presence of this mutation is called ALDH2 deficiency. Because of limited ability to metabolize acetaldehyde, individuals with ALDH2 deficiency experience elevated levels of blood acetaldehyde after exposure to various common sources such as recreational alcohol. Because of higher levels of acetaldehyde, individuals with ALDH2 deficiency are at higher risk for numerous diseases, including liver cirrhosis, esophageal and gastric cancer, osteoporosis, and Alzheimer disease...
February 21, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29507261/supporting-diverse-challenges-of-ageing-with-digital-enhanced-living-solutions
#8
John Grundy, Kon Mouzakis, Rajesh Vasa, Andrew Cain, Maheswaree Curumsing, Mohamed Abdelrazek, Niroshine Fernando
By the 2050, it is estimated that the proportion of people over the age of 80 will have risen from 3.9% to 9.1% of population of Organisation for Economic Cooperation and Development countries. A large proportion of these people will need significant help to manage various chronic illnesses, including dementia, heart disease, diabetes, limited physical movement and many others. Current approaches typically focus on acute episodes of illness and are not well designed to provide adequately for daily living care support...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29480200/homocysteine-and-dementia-an-international-consensus-statement
#9
A David Smith, Helga Refsum, Teodoro Bottiglieri, Michael Fenech, Babak Hooshmand, Andrew McCaddon, Joshua W Miller, Irwin H Rosenberg, Rima Obeid
Identification of modifiable risk factors provides a crucial approach to the prevention of dementia. Nutritional or nutrient-dependent risk factors are especially important because dietary modifications or use of dietary supplements may lower the risk factor level. One such risk factor is a raised concentration of the biomarker plasma total homocysteine, which reflects the functional status of three B vitamins (folate, vitamins B12, B6). A group of experts reviewed literature evidence from the last 20 years...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29458929/physical-activity-is-associated-with-higher-cognitive-function-among-adults-at-risk-for-alzheimer-s-disease
#10
Emily Frith, Paul D Loprinzi
OBJECTIVE: We evaluated the specific association between physical activity and cognitive function among a national sample of the broader U.S. adult population with a family history of Alzheimer's disease. METHODS: Data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES) were used to identify 219 older adults, ages 60-85, with a family history of Alzheimer's disease. The Digit Symbol Substitution Test (DSST) was used to assess cognitive function, with physical activity assessed via a validated questionnaire...
February 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29456585/neuroinflammation-and-neurohormesis-in-the-pathogenesis-of-alzheimer-s-disease-and-alzheimer-linked-pathologies-modulation-by-nutritional-mushrooms
#11
REVIEW
Angela Trovato Salinaro, Manuela Pennisi, Rosanna Di Paola, Maria Scuto, Rosalia Crupi, Maria Teresa Cambria, Maria Laura Ontario, Mario Tomasello, Maurizio Uva, Luigi Maiolino, Edward J Calabrese, Salvatore Cuzzocrea, Vittorio Calabrese
Human life develops and expands not only in time and space, but also in the retrograde permanent recollection and interweaving of memories. Therefore, individual human identity depends fully on a proper access to the autobiographical memory. Such access is hindered or lost under pathological conditions such as Alzheimer's disease, including recently associated oxidant pathologies, such as ocular neural degeneration occurring in glaucoma or neurosensorial degeneration occurring in Menière's disease. Oxidative stress and altered antioxidant systems have been suggested to play a role in the aetiology of major neurodegenerative disorders, and altered expression of genes sensing oxidative stress, as well as decreased cellular stress response mechanisms could synergistically contribute to the course of these oxidant disorders...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29454265/supplementation-of-lycopene-attenuates-lipopolysaccharide-induced-amyloidogenesis-and-cognitive-impairments-via-mediating-neuroinflammation-and-oxidative-stress
#12
Jia Wang, Lixia Li, Zhuo Wang, Yifan Cui, Xintong Tan, Tian Yuan, Qian Liu, Zhigang Liu, Xuebo Liu
Neuroinflammation is documented to be the major culprit of Alzheimer's disease. Lycopene (LYC), a fat soluble carotenoid, exhibits neuroprotective function in several neurodegenerative disorders. However, the effects of LYC to countering systemic inflammation-induced amyloidogenesis and memory deficiency remain to be elucidated. In current study, 3-month-old male C57BL/6J mice were treated with 0.03% LYC (w/w, mixed into normal chow) for 5 weeks. The mice were then treated by intraperitoneal injection of LPS (0...
February 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29442498/proteostasis-and-the-regulation-of-intra-and-extracellular-protein-aggregation-by-atp-independent-molecular-chaperones-lens-%C3%AE-crystallins-and-milk-caseins
#13
John A Carver, Heath Ecroyd, Roger J W Truscott, David C Thorn, Carl Holt
Molecular chaperone proteins perform a diversity of roles inside and outside the cell. One of the most important is the stabilization of misfolding proteins to prevent their aggregation, a process that is potentially detrimental to cell viability. Diseases such as Alzheimer's, Parkinson's, and cataract are characterized by the accumulation of protein aggregates. In vivo, many proteins are metastable and therefore under mild destabilizing conditions have an inherent tendency to misfold, aggregate, and hence lose functionality...
February 14, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29361990/dietary-inflammatory-index-and-memory-function-population-based-national-sample-of-elderly-americans
#14
Emily Frith, Nitin Shivappa, Joshua R Mann, James R Hébert, Michael D Wirth, Paul D Loprinzi
The objective of this study was to examine the association between dietary inflammatory potential and memory and cognitive functioning among a representative sample of the US older adult population. Cross-sectional data from the 2011-2012 and 2013-2014 National Health and Nutrition Examination Survey were utilised to identify an aggregate sample of adults 60-85 years of age (n 1723). Dietary inflammatory index (DII®) scores were calculated using 24-h dietary recall interviews. Three memory-related assessments were employed, including the Consortium to Establish a Registry for Alzheimer's disease (CERAD) Word Learning subset, the Animal Fluency test and the Digit Symbol Substitution Test (DSST)...
March 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29361063/progressive-support-for-activities-of-daily-living-for-persons-living-with-dementia
#15
Lindsay P Prizer, Sheryl Zimmerman
Background and Objectives: Dementia is accompanied by increasing need for support in activities of daily living (ADLs). This brief report/literature review summarizes the practices to care for early stage, middle stage, and late stage ADL needs (dressing, toileting, and eating/nutrition), and examines commonalities across ADL needs and the extent to which practices are reflected in guidelines and/or evidence. Research Design and Methods: A review of the grey and peer-reviewed literature, using some but not all procedures of a systematic review...
January 18, 2018: Gerontologist
https://www.readbyqxmd.com/read/29360225/olfactory-dysfunction-and-cognition-among-older-adults-in-the-united-states
#16
Janet S Choi, Kevin Hur, Michael Chow, Jasper Shen, Bozena Wrobel
BACKGROUND: In this work we assess the association between olfactory dysfunction and cognition in a nationally representative sample of older adults in the United States. METHODS: Participants aged ≥60 years (n = 1236) from the 2013-2014 National Health and Nutritional Examination Survey underwent both olfactory and cognitive testing. Olfaction was assessed by both objective test (8-odor Pocket Smell Test: smell impairment defined as score ≤2) and self-report...
January 23, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29344321/fixed-drug-eruption-to-supplement-containing-ginkgo-biloba-and-vinpocetine-a-case-report-and-review-of-related-cutaneous-side-effects
#17
Philip R Cohen
BACKGROUND: Fixed drug eruption is a cutaneous reaction to a systemic agent that typically presents as an annular or oval erythematous patch or blister and subsequently resolves with postinflammatory hyperpigmentation at the site. Ginkgo biloba leaf extract and vinpocetine are nutritional supplements used to enhance memory in patients with dementia and age-related memory impairment conditions such as Alzheimer's disease. PURPOSE: To describe a fixed drug eruption in a man who repeatedly developed pruritus and macular erythema on his distal penile shaft after ingesting a natural product containing Ginkgo biloba and vinpocetine...
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29298649/an-inflammation-related-nutrient-pattern-is-associated-with-both-brain-and-cognitive-measures-in-a-multiethnic-elderly-population
#18
Yian Gu, Jennifer J Manly, Richard P Mayeux, Adam M Brickman
BACKGROUND: Accumulating evidence suggests that dietary factors are associated with Alzheimer's disease, cognition, and brain health in older adults. It is however unclear whether inflammation explains this association. OBJECTIVE: To examine whether an inflammation-related nutrient pattern (INP) was associated with neuroimaging and cognitive measures of brain health. METHOD: The current cross-sectional study included 330 non-demented elderly (mean age 79 years at MRI scan) participants in a multi-ethnic, community-based cohort study who had information on nutritional intake (estimated from food frequency questionnaire), circulating C-reactive protein and interleukin- 6 (measured by ELISA), MRI scans, and cognition...
March 14, 2018: Current Alzheimer Research
https://www.readbyqxmd.com/read/29258624/a-selenium-species-in-cerebrospinal-fluid-predicts-conversion-to-alzheimer-s-dementia-in-persons-with-mild-cognitive-impairment
#19
Marco Vinceti, Annalisa Chiari, Marcel Eichmüller, Kenneth J Rothman, Tommaso Filippini, Carlotta Malagoli, Jennifer Weuve, Manuela Tondelli, Giovanna Zamboni, Paolo F Nichelli, Bernhard Michalke
BACKGROUND: Little is known about factors influencing progression from mild cognitive impairment to Alzheimer's dementia. A potential role of environmental chemicals and specifically of selenium, a trace element of nutritional and toxicological relevance, has been suggested. Epidemiologic studies of selenium are lacking, however, with the exception of a recent randomized trial based on an organic selenium form. METHODS: We determined concentrations of selenium species in cerebrospinal fluid sampled at diagnosis in 56 participants with mild cognitive impairment of nonvascular origin...
December 19, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29249963/exploring-the-association-between-alzheimer-s-disease-oral-health-microbial-endocrinology-and-nutrition
#20
REVIEW
Alice Harding, Ulrike Gonder, Sarita J Robinson, StJohn Crean, Sim K Singhrao
Longitudinal monitoring of patients suggests a causal link between chronic periodontitis and the development of Alzheimer's disease (AD). However, the explanation of how periodontitis can lead to dementia remains unclear. A working hypothesis links extrinsic inflammation as a secondary cause of AD. This hypothesis suggests a compromised oral hygiene leads to a dysbiotic oral microbiome whereby Porphyromonas gingivalis , a keystone periodontal pathogen, with its companion species, orchestrates immune subversion in the host...
2017: Frontiers in Aging Neuroscience
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