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Alzheimers and alcohol

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https://www.readbyqxmd.com/read/28314118/in-vitro-assay-development-and-hts-of-small-molecule-human-abad-17%C3%AE-hsd10-inhibitors-as-therapeutics-in-alzheimer-s-disease
#1
Laura Aitken, Gemma Baillie, Andrew Pannifer, Angus Morrison, Philip S Jones, Terry K Smith, Stuart P McElroy, Frank J Gunn-Moore
A major hallmark of Alzheimer's disease (AD) is the formation of neurotoxic aggregates composed of the amyloid-β peptide (Aβ). Aβ has been recognized to interact with numerous proteins, resulting in pathological changes to the metabolism of patients with AD. One such mitochondrial metabolic enzyme is amyloid-binding alcohol dehydrogenase (ABAD), where altered enzyme function caused by the Aβ-ABAD interaction is known to cause mitochondrial distress and cytotoxic effects, providing a feasible therapeutic target for AD drug development...
March 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28300627/serum-uric-acid-is-associated-with-better-executive-function-in-men-but-not-in-women-baseline-assessment-of-the-elsa-brasil-study
#2
Cristina Pellegrino Baena, Claudia Kimie Suemoto, Sandhi Barreto, Paulo Lotufo, Isabela Benseñor
BACKGROUND: Serum uric acid (SUA) may protect against free radical stress damage and was previously linked to cognitive impairment in older adults, but evidence in middle-aged adults is scarce. PURPOSE: We sought to analyze whether SUA is associated with cognitive performance in apparently healthy middle-aged participants in the ELSA-Brasil cohort study. METHODS: We excluded participants older than age 65, those taking allopurinol, benzbromarone, or medications that could impair cognitive performance, those with previous stroke, and those with incomplete data on cognitive tests or SUA...
March 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28275046/self-reported-sleep-disturbance-and-incidence-of-dementia-in-ageing-men
#3
Maria K Luojus, Soili M Lehto, Tommi Tolmunen, Anna-Katharine Brem, Eija Lönnroos, Jussi Kauhanen
BACKGROUND: Sleep disturbance is suggested to contribute to the development of dementia. However, prospective longitudinal data from middle-aged populations are scarce. METHODS: We investigated a population-based sample of 2386 men aged 42-62 years at baseline during 1984-1989. Participants having a history of mental illnesses, psychiatric medication, Parkinson's disease or dementia within 2 years after baseline (n=296) were excluded. Difficulty falling asleep or maintaining sleep, sleep duration and daytime tiredness were enquired...
April 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28223234/advanced-glycation-end-products-produced-systemically-and-by-macrophages-a-common-contributor-to-inflammation-and-degenerative-diseases
#4
REVIEW
Kyunghee Byun, YongCheol Yoo, Myeongjoo Son, Jaesuk Lee, Goo-Bo Jeong, Young Mok Park, Ghasem Hosseini Salekdeh, Bonghee Lee
Advanced glycation end products (AGEs) and their receptor have been implicated in the progressions of many intractable diseases, such as diabetes and atherosclerosis, and are also critical for pathologic changes in chronic degenerative diseases, such as Alzheimer's disease, Parkinson's disease, and alcoholic brain damage. Recently activated macrophages were found to be a source of AGEs, and the most abundant form of AGEs, AGE-albumin excreted by macrophages has been implicated in these diseases and to act through common pathways...
February 13, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28199971/association-and-interaction-effects-of-alzheimer-s-disease-associated-genes-and-lifestyle-on-cognitive-aging-in-older-adults-in-a-taiwanese-population
#5
Eugene Lin, Shih-Jen Tsai, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao
Genome-wide association studies and meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, MS4A4E, MS4A6E, NME8, PICALM, PLD3, PTK2B, RIN3, SLC24A4, SORL1, and ZCWPW1 genes. In this study, we assessed whether single nucleotide polymorphisms (SNPs) within these 27 AD-associatedgenes are linked with cognitive aging independently and/or through complex interactions in an older Taiwanese population...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28182204/alcohol-and-alzheimer-s-disease-does-alcohol-dependence-contribute-to-beta-amyloid-deposition-neuroinflammation-and-neurodegeneration-in-alzheimer-s-disease
#6
REVIEW
Ashwin Venkataraman, Nicola Kalk, Gavin Sewell, Craig W Ritchie, Anne Lingford-Hughes
No abstract text is available yet for this article.
March 9, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28179815/considering-sex-and-gender-in-alzheimer-disease-and-other-dementias
#7
Jessica L Podcasy, C Neill Epperson
Suffering related to dementia is multifaceted because cognitive and physical functioning slowly deteriorates. Advanced age and sex, two of the most prominent risk factors for dementia, are not modifiable. Lifestyle factors such as smoking, excessive alcohol use, and poor diet modulate susceptibility to dementia in both males and females. The degree to which the resulting health conditions (eg, obesity, type 2 diabetes, and cardiovascular disease) impact dementia risk varies by sex. Depending on the subtype of dementia, the ratio of male to female prevalence differs...
December 2016: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28166686/antidepressant-and-anxiolytic-activity-of-lavandula-officinalis-aerial-parts-hydroalcoholic-extract-in-scopolamine-treated-rats
#8
Batool Rahmati, Zahra Kiasalari, Mehrdad Roghani, Mohsen Khalili, Fariba Ansari
CONTEXT: Anxiety and depression are common in Alzheimer's disease (AD). Despite some evidence, it is difficult to confirm Lavandula officinalis Chaix ex Vill (Lamiaceae) as an anxiolytic and antidepressant drug. OBJECTIVE: The effects of L. officinalis extract were studied in scopolamine-induced memory impairment, anxiety and depression-like behaviour. MATERIALS AND METHODS: Male NMRI rats were divided into control, scopolamine alone-treated group received scopolamine (0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28164772/clinical-and-environmental-correlates-of-serum-bdnf-a-descriptive-study-with-plausible-implications-for-ad-research
#9
Galit Weinstein, Sarah R Preis, Alexa S Beiser, Bernhard Kaess, Tai C Chen, Claudia Satizabal, Faisal Rahman, Emelia J Benjamin, Vasan S Ramachandran, Sudha Seshadri
BACKGROUND: Brain derived neurotrophic factor (BDNF) may play a central role in the pathogenesis of Alzheimer's disease (AD) through neurotrophic effects on basal cholinergic neurons. Reduced serum levels of BDND are observed among AD patients and may predict AD risk. Nevertheless, knowledge about factors associated with its levels in blood is lacking. OBJECTIVE: To identify clinical and demographic correlated of serum BDNF levels . METHODS: BDNF was measured from serum collected between 1992-1996 and 1998-2001 in participants from the Original and Offspring cohorts of the Framingham Study, respectively...
February 2, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28128767/chronic-neurodegenerative-illnesses-and-epilepsy-in-danish-adventists-and-baptists-a-nationwide-cohort-study
#10
Lau Caspar Thygesen, Louise NØrreslet Gimsing, Andrea Bautz, Niels Christian Hvidt, Christoffer Johansen
BACKGROUND: Limited knowledge of the influence of lifestyle risk factors and religious living on chronic neurological diseases exists. Seventh-day Adventists (SDA) do not consume tobacco, alcohol, or pork, and many adhere to lacto-ovo-vegetarian diet, and Baptists discourage excessive use of alcohol and tobacco. OBJECTIVE: We investigated whether the incidence of four common chronic neurological illnesses: dementia, Alzheimer's disease, Parkinson's disease, and epilepsy in a large cohort of Danish Adventists and Baptists was different compared to the general Danish population...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28115835/potentially-inappropriate-medications-use-in-community-based-aged-patients-a-cross-sectional-study-using-2012-beers-criteria
#11
Rony Zeenny, Samira Wakim, Yara-Mary Kuyumjian
BACKGROUND: Potentially inappropriate medications (PIMs) should be avoided by the aged population. The aim of this study was to assess the prevalence of PIMs among Lebanese aged outpatients using Beers criteria of 2012. The secondary objectives were to identify the correlates of the PIMs use and to compare the PIMs prevalence rates as per Beers criteria of 2003 and 2012. METHODS: This cross-sectional observational study was conducted among aged outpatients of different accredited community pharmacies across Lebanon...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28097521/alcohol-consumption-and-dementia-risk-a-dose-response-meta-analysis-of-prospective-studies
#12
Wei Xu, Huifu Wang, Yu Wan, Chenchen Tan, Jieqiong Li, Lan Tan, Jin-Tai Yu
It is widely believed that light-to-moderate alcohol intake may protect against dementia while excessive drinking may instead increase the risk. Nonetheless, these findings need cautious interpretations due to varying methodologies and lack of standard definition, which hindered our transferring into preventative practice. The objective of this study is to investigate the potential dose-response association between alcohol consumption and risk of dementia. A systematic search was conducted in electronic databases to identify relevant studies...
January 17, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28067167/6-benzothiazolyl-ureas-thioureas-and-guanidines-are-potent-inhibitors-of-abad-17%C3%AE-hsd10-and-potential-drugs-for-alzheimer-s-disease-treatment-design-synthesis-and-in-vitro-evaluation
#13
Ondrej Benek, Lukas Hroch, Laura Aitken, Rafael Dolezal, Patrick Guest, Marketa Benkova, Ondrej Soukup, Karel Musil, Kamil Kuca, Terry K Smith, Frank Gunn-Moore, Kamil Musilek
BACKGROUND: The mitochondrial enzyme amyloid beta-binding alcohol dehydrogenase (ABAD) also known as 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) has been connected with the pathogenesis of Alzheimer's disease (AD). ABAD/ 17β-HSD10 is a binding site for the amyloid-beta peptide (Aβ) inside the mitochondrial matrix where it exacerbates Aβ toxicity. Interaction between these two proteins triggers a series of events leading to mitochondrial dysfunction as seen in AD. METHODS: As ABAD's enzymatic activity is required for mediating Aβ toxicity, its inhibition presents a promising strategy for AD treatment...
January 9, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28033505/transgenerational-transmission-of-an-anticholinergic-endophenotype-with-memory-dysfunction
#14
Wolfram Doehner, Lieselotte Praße, James Wolpers, Martina K Brückner, Uwe Ueberham, Thomas Arendt
Impaired cholinergic neurotransmission associated with cognitive dysfunction occurs in various mental disorders of different etiologies including Alzheimer's disease and postalcoholic dementia and others. To address the question whether there exists a common endophenotype with a defined genetic and/or epigenetic signature causing mental dysfunction in these disorders, we investigated 2 generations of offspring born to alcohol-treated mothers. Here, we show that memory impairment and reduced synthesis of acetylcholine occurs in both F1 (exposed to ethanol in utero) and F2 generation (never been exposed to ethanol)...
March 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28003246/erratum-alcohol-and-alzheimer-s-disease-does-alcohol-dependence-contribute-to-beta-amyloid-deposition-neuroinflammation-and-neurodegeneration-in-alzheimer-s-disease
#15
Ashwin Venkataraman, Nicola Kalk, Gavin Sewell, Craig W Ritchie, Anne Lingford-Hughes
No abstract text is available yet for this article.
December 20, 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27997158/chaperone-like-activity-of-calnuc-prevents-amyloid-aggregation
#16
Madhavi Kanuru, Gopala Krishna Aradhyam
Calnuc is a ubiquitously expressed protein of the EF-hand Ca(2+)-binding superfamily. Previous studies have implicated it in Ca(2+)-sensitive physiological processes, whereas details of its function and involvement in human diseases are lacking. Drawing upon the sequence homology of calnuc with calreticulin, we propose it functions as a molecular chaperone-like protein. In cells under thermal, chemical [urea and guanidinium chloride (GdmCl)], and acidic stress, calnuc exhibits properties similar to those of established chaperone-like proteins (GRP78, spectrin, and α-crystallin), effectively demonstrated by its ability to suppress aggregation of malate dehydrogenase (MDH), alcohol dehydrogenase, and catalase...
December 20, 2016: Biochemistry
https://www.readbyqxmd.com/read/27992612/the-calculator-of-anti-alzheimer-s-diet-macronutrients
#17
Marcin Studnicki, Grażyna Woźniak, Dariusz Stępkowski
The opinions about optimal proportions of macronutrients in a healthy diet have changed significantly over the last century. At the same time nutritional sciences failed to provide strong evidence backing up any of the variety of views on macronutrient proportions. Herein we present an idea how these proportions can be calculated to find an optimal balance of macronutrients with respect to prevention of Alzheimer's Disease (AD) and dementia. These calculations are based on our published observation that per capita personal income (PCPI) in the USA correlates with age-adjusted death rates for AD (AADR)...
2016: PloS One
https://www.readbyqxmd.com/read/27988872/insulin-resistance-and-neurodegeneration-progress-towards-the-development-of-new-therapeutics-for-alzheimer-s-disease
#18
REVIEW
Suzanne M de la Monte
Alzheimer's disease (AD) should be regarded as a degenerative metabolic disease caused by brain insulin resistance and deficiency, and overlapping with the molecular, biochemical, pathophysiological, and metabolic dysfunctions in diabetes mellitus, non-alcoholic fatty liver disease, and metabolic syndrome. Although most of the diagnostic and therapeutic approaches over the past several decades have focused on amyloid-beta (Aβ42) and aberrantly phosphorylated tau, which could be caused by consequences of brain insulin resistance, the broader array of pathologies including white matter atrophy with loss of myelinated fibrils and leukoaraiosis, non-Aβ42 microvascular disease, dysregulated lipid metabolism, mitochondrial dysfunction, astrocytic gliosis, neuro-inflammation, and loss of synapses vis-à-vis growth of dystrophic neurites, is not readily accounted for by Aβ42 accumulations, but could be explained by dysregulated insulin/IGF-1 signaling with attendant impairments in signal transduction and gene expression...
December 17, 2016: Drugs
https://www.readbyqxmd.com/read/27965104/identification-of-risk-pathways-and-functional-modules-for-coronary-artery-disease-based-on-genome-wide-snp-data
#19
Xiang Zhao, Yi-Zhao Luan, Xiaoyu Zuo, Ye-Da Chen, Jiheng Qin, Lv Jin, Yiqing Tan, Meihua Lin, Naizun Zhang, Yan Liang, Shao-Qi Rao
Coronary artery disease (CAD) is a complex human disease, involving multiple genes and their nonlinear interactions, which often act in a modular fashion. Genome-wide single nucleotide polymorphism (SNP) profiling provides an effective technique to unravel these underlying genetic interplays or their functional involvements for CAD. This study aimed to identify the susceptible pathways and modules for CAD based on SNP omics. First, the Wellcome Trust Case Control Consortium (WTCCC) SNP datasets of CAD and control samples were used to assess the joint effect of multiple genetic variants at the pathway level, using logistic kernel machine regression model...
December 2016: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/27932366/sauna-bathing-is-inversely-associated-with-dementia-and-alzheimer-s-disease-in-middle-aged-finnish-men
#20
Tanjaniina Laukkanen, Setor Kunutsor, Jussi Kauhanen, Jari Antero Laukkanen
BACKGROUND: there are no previous studies linking repeated heat exposure of sauna and the risk of memory diseases. We aimed to investigate whether frequency of sauna bathing is associated with risk of dementia and Alzheimer's disease. SETTING: prospective population-based study. METHODS: the frequency of sauna bathing was assessed at baseline in the Kuopio Ischaemic Heart Disease population-based prospective cohort study of 2,315 apparently healthy men aged 42-60 years at baseline, with baseline examinations conducted between 1984 and 1989...
December 7, 2016: Age and Ageing
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