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Alzheimers and alcohol

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https://www.readbyqxmd.com/read/29117869/frequency-of-use-of-the-international-classification-of-diseases-icd-10-diagnostic-categories-for-mental-and-behavioural-disorders-across-world-regions
#1
Y Faiad, B Khoury, S Daouk, M Maj, J Keeley, O Gureje, G Reed
AIMS: The study aimed to examine variations in the use of International Classification of Diseases, Tenth Edition (ICD-10) diagnostic categories for mental and behavioural disorders across countries, regions and income levels using data from the online World Psychiatric Association (WPA)-World Health Organization (WHO) Global Survey that examined the attitudes of psychiatrists towards the classification of mental disorders. METHODS: A survey was sent to 46 psychiatric societies which are members of WPA...
November 9, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29103404/the-cerad-neuropsychological-assessment-battery-is-sensitive-to-alcohol-related-cognitive-deficiencies-in-elderly-patients-a-retrospective-matched-case-control-study
#2
Liane Kaufmann, Stefan Huber, Daniel Mayer, Korbinian Moeller, Josef Marksteiner
OBJECTIVES: Adverse effects of heavy drinking on cognition have frequently been reported. In the present study, we systematically examined for the first time whether clinical neuropsychological assessments may be sensitive to alcohol abuse in elderly patients with suspected minor neurocognitive disorder. METHODS: A total of 144 elderly with and without alcohol abuse (each group n=72; mean age 66.7 years) were selected from a patient pool of n=738 by applying propensity score matching (a statistical method allowing to match participants in experimental and control group by balancing various covariates to reduce selection bias)...
November 6, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29101021/microglial-specific-transcriptome-changes-following-chronic-alcohol-consumption
#3
Gizelle M McCarthy, Sean P Farris, Yuri A Blednov, R Adron Harris, R Dayne Mayfield
Microglia are fundamentally important immune cells within the central nervous system (CNS) that respond to environmental challenges to maintain normal physiological processes. Alterations in steady-state cellular function and over-activation of microglia can facilitate the initiation and progression of neuropathological conditions such as Alzheimer's disease, Multiple Sclerosis, and Major Depressive Disorder. Alcohol consumption disrupts signaling pathways including both innate and adaptive immune responses that are necessary for CNS homeostasis...
October 31, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29066899/sex-differences-in-obesity-and-cognitive-function-in-a-cognitively-normal-aging-chinese-han-population
#4
Wei Li, Qi Qiu, Lin Sun, Ling Yue, Tao Wang, Xia Li, Shifu Xiao
BACKGROUND: Sex differences in Alzheimer's disease and mild cognitive impairment have been well recognized. However, sex differences in cognitive function and obesity in cognitively normal aging Chinese Han population have not attracted much attention. OBJECTIVE: The aim of this study was to investigate the relationship between sex, obesity, and cognitive function in an elderly Chinese population with normal cognitive function. SUBJECTS AND METHODS: A total of 228 cognitively normal aging participants (males/females =93/135) entered this study...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29058954/migraine-and-cognitive-function-baseline-findings-from-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#5
Cristina Pellegrino Baena, Alessandra Carvalho Goulart, Itamar de Souza Santos, Claudia Kimie Suemoto, Paulo Andrade Lotufo, Isabela Judith Bensenor
Background The association between migraine and cognitive performance is unclear. We analyzed whether migraine is associated with cognitive performance among participants of the Brazilian Longitudinal Study of Adult Health, ELSA-Brasil. Methods Cross-sectional analysis, including participants with complete information about migraine and aura at baseline. Headache status (no headaches, non-migraine headaches, migraine without aura and migraine with aura), based on the International Headache Society classification, was used as the dependent variable in the multilinear regression models, using the category "no headache" as reference...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29036813/association-between-later-life-lifestyle-factors-and-alzheimer-s-disease-biomarkers-in-non-demented-individuals-a-longitudinal-descriptive-cohort-study
#6
Babette L R Reijs, Stephanie J B Vos, Hilkka Soininen, Jyrki Lötjonen, Juha Koikkalainen, Maria Pikkarainen, Anette Hall, Ritva Vanninen, Yawu Liu, Sanna-Kaisa Herukka, Yvonne Freund-Levi, Giovanni B Frisoni, Lutz Frölich, Flavio Nobili, Marcel Olde Rikkert, Luiza Spiru, Magda Tsolaki, Åsa K Wallin, Philip Scheltens, Frans Verhey, Pieter Jelle Visser
BACKGROUND: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. OBJECTIVE: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI...
October 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29034195/protective-effect-of-hydro-alcoholic-extract-of-salvia-haematodes-wall-root-on-cognitive-functions-in-scopolamine-induced-amnesia-in-rats
#7
Mohammad Shawwal, Badruddeen, Mohammad Khushtar, Md Azizur Rahman
Diminished cholinergic transmission may be responsible for development of amnesia. Hence, the present study was undertaken to investigate the possible protective effect of hydro-alcoholic extract of Salvia haematodes Wall root (HESH) on cognitive functions in scopolamine-induced amnesia in adult Sprague Dawley rats. The rats were divided randomly into five groups each consisting of five rats (n = 5). Rats of the groups I, II, III, IV, and V received orally normal saline (10 ml/kg b. wt.), normal saline (10 ml/kg), standard drug rivastigmine (1...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29032150/functional-analysis-of-schizophrenia-genes-using-geneanalytics-program-and-integrated-databases
#8
Tharani Sundararajan, Ann M Manzardo, Merlin G Butler
Schizophrenia (SCZ) is a chronic debilitating neuropsychiatric disorder with multiple risk factors involving numerous complex genetic influences. We examined and updated a master list of clinically relevant and susceptibility genes associated with SCZ reported in the literature and genomic databases dedicated to gene discovery for characterization of SCZ genes. We used the commercially available GeneAnalytics computer-based gene analysis program and integrated genomic databases to create a molecular profile of the updated list of 608 SCZ genes to model their impact in select categories (tissues and cells, diseases, pathways, biological processes, molecular functions, phenotypes and compounds) using specialized GeneAnalytics algorithms...
October 12, 2017: Gene
https://www.readbyqxmd.com/read/28992692/rare-hybrid-dimers-with-anti-acetylcholinesterase-activities-from-a-safflower-carthamus-tinctorius-l-seed-oil-cake
#9
Xing-Rong Peng, Xia Wang, Jin-Run Dong, Xu-Jie Qin, Zhong-Rong Li, Han Yang, Lin Zhou, Ming-Hua Qiu
Safflower (Carthamus tinctorius) is commercially cultivated for vegetable oil extracted from the seeds. However, during the production process of seed oil, a large amount of the oil cake is thrown away or fermented as fertilizer to improve the homing rate of pigeons. Therefore, to solve the ecological problem and develop its new function, we investigated the chemical constituents of a safflower seed oil cake, and six new hybrid dimers, (±)-carthatins A-F (1-6, respectively), with a phenylpropanoid and a feruloylserotonin fused via a dihydrofuran ring, together with four known compounds, including sinapyl alcohol (7), coniferyl alcohol (8), serotobenine (9), and feruloylserotonin (10), were isolated...
October 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28984595/low-prevalence-and-clinical-effect-of-vascular-risk-factors-in-early-onset-alzheimer-s-disease
#10
Yaohua Chen, Adeline Rollin Sillaire, Jean Dallongeville, Emilie Skrobala, David Wallon, Bruno Dubois, Didier Hannequin, Florence Pasquierthe
BACKGROUND: Determinants of early-onset Alzheimer's disease (EOAD) are not well known. In late-onset AD, vascular risk factors (VRFs) are associated with earlier clinical manifestation. OBJECTIVE: The objective of this study was to assess the putative association between VRFs and EOAD. METHODS: We studied participants with dementia meeting criteria for EOAD (recruited into the French CoMAJ prospective cohort study from 1 June 2009 to 28 February 2014) and age-, gender-matched controls (ratio 1:3, drawn randomly from the French MONA-LISA population-based survey between 2005 and 2007)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28936398/vitamin-d-is-associated-with-severity-and-mortality-of-non-alcoholic-fatty-liver-disease-a-us-population-based-study
#11
Hyun-Seok Kim, Laura Rotundo, Neil Kothari, Sung-Hoon Kim, Nikolaos Pyrsopoulos
Background and Aims: There has been increasing evidence that vitamin D deficiency may increase the risk of metabolic syndrome. Since metabolic syndrome is a major risk factor for non-alcoholic fatty liver disease (NAFLD), we aimed to investigate the association between vitamin D and the severity and mortality of NAFLD. Methods: Data was obtained from the United States Third National Health and Nutrition Examination Survey conducted in 1988-1994, with follow-up mortality data through 2011. NAFLD was defined by ultrasonographic detection of hepatic steatosis in the absence of other liver diseases and categorized as normal, mild, moderate or severe...
September 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28923026/dementia-and-cognitive-disorder-identified-at-a-forensic-psychiatric-examination-a-study-from-sweden
#12
Anette Ekström, Marianne Kristiansson, Karin Sparring Björkstén
BACKGROUND: Few studies have addressed the relationship between dementia and crime. We conducted a study of persons who got a primary or secondary diagnosis of dementia or cognitive disorder in a forensic psychiatric examination. METHODS: In Sweden, annually about 500 forensic psychiatric examinations are carried out. All cases from 2008 to 2010 with the diagnoses dementia or cognitive disorder were selected from the database of the Swedish National Board of Forensic Medicine...
September 18, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28910193/lifestyle-markers-predict-cognitive-function
#13
Steven C Masley, Richard Roetzheim, Gwendolyn Clayton, Angela Presby, Kelley Sundberg, Lucas V Masley
OBJECTIVE: Rates of mild cognitive impairment and Alzheimer's disease are increasing rapidly. None of the current treatment regimens for Alzheimer's disease are effective in arresting progression. Lifestyle choices may prevent cognitive decline. This study aims to clarify which factors best predict cognitive function. METHODS: This was a prospective cross-sectional analysis of 799 men and women undergoing health and cognitive testing every 1 to 3 years at an outpatient center...
September 14, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28901441/profiling-of-differentially-expressed-genes-in-adipose-tissues-of-multiple-symmetric-lipomatosis
#14
Ke Chen, Linghao Wang, Wenjun Yang, Changfa Wang, Gui Hu, Zhaohui Mo
Multiple symmetric lipomatosis (MSL) is a rare disorder characterized by aberrant multiple and symmetric subcutaneous adipose tissue accumulation in the face, neck, shoulders, back, chest and abdomen, severely affecting the quality of life of patients. At present, precise MSL etiology and pathogenesis remain to be elucidated. The present study first utilized a digital gene expression technique with a next‑generation sequencing platform to profile differentially expressed genes in three cases of MSL vs. normal control tissue...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28842833/ceramide-and-its-related-neurochemical-networks-as-targets-for-some-brain-disorder-therapies
#15
REVIEW
Justyna Brodowicz, Edmund Przegaliński, Christian P Müller, Malgorzata Filip
Correlational and causal comparative research link ceramide (Cer), the precursor of complex sphingolipids, to some psychiatric (e.g., depression, schizophrenia (SZ), alcohol use disorder, and morphine antinociceptive tolerance) and neurological (e.g., Alzheimer's disease (AD), Parkinson disease (PD)) disorders. Cer generation can occur through the de novo synthesis pathway, the sphingomyelinase pathways, and the salvage pathway. The discoveries that plasma Cer concentration increase during depressive episodes in patients and that tricyclic and tetracyclic antidepressants functionally inhibit acid sphingomyelinase (ASM), the enzyme that catalyzes the degradation of sphingomyelin to Cer, have initiated a series of studies on the role of the ASM-Cer system in depressive disorder...
August 25, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28818082/comparing-chronic-condition-rates-using-icd-9-and-icd-10-in-va-patients-fy2014-2016
#16
Jean Yoon, Adam Chow
BACKGROUND: Management of patients with chronic conditions relies on accurate measurement. It is unknown how transition to the ICD-10 coding system affected reporting of chronic condition rates over time. We measured chronic condition rates 2 years before and 1 year after the transition to ICD-10 to examine changes in prevalence rates and potential measurement issues in the Veterans Affairs (VA) health care system. METHODS: We developed definitions for 34 chronic conditions using ICD-9 and ICD-10 codes and compared the prevalence rates of these conditions from FY2014 to 2016 in a 20% random sample (1...
August 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28806610/risk-factors-of-transition-from-mild-cognitive-impairment-to-alzheimer-s-disease-and-death-a-cohort-study
#17
Haihong Xue, Qianqian Sun, Long Liu, Liye Zhou, Ruifeng Liang, Runlian He, Hongmei Yu
BACKGROUND: Knowledge of risk factors is essential for developing strategies that prevent or minimise transitions from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and death. The aim of this study was to assess risk factors for progression to AD and death among Chinese individuals with cognitive impairment. METHODS: We conducted a multisite, population-based cohort study on 437 community-dwelling elderly MCI residents in Taiyuan, China from 2010 to 2014...
October 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28799137/ethanol-alters-app-processing-and-aggravates-alzheimer-associated-phenotypes
#18
Daochao Huang, Mengjiao Yu, Shou Yang, Dandan Lou, Weitao Zhou, Lingling Zheng, Zhe Wang, Fang Cai, Weihui Zhou, Tingyu Li, Weihong Song
The majority of Alzheimer's disease (AD) cases are sporadic with unknown causes. Many dietary factors including excessive alcohol intake have been reported to increase the risk to develop AD. The effect of alcohol on cognitive functions and AD pathogenesis remains elusive. In this study, we investigated the relationship between ethanol exposure and Alzheimer's disease. Cell cultures were treated with ethanol at different dosages for different durations up to 48 h and an AD model mouse was fed with ethanol for 4 weeks...
August 10, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28796009/different-exposures-to-risk-factors-do-not-explain-the-inverse-relationship-of-occurrence-between-cancer-and-neurodegenerative-diseases-an-italian-nested-case-control-study
#19
Federica Prinelli, Fulvio Adorni, Maria Lea Correa Leite, Carla Pettenati, Antonio Russo, Simona Di Santo, Massimo Musicco
Several studies reported that cancer is less frequent in persons with Alzheimer's and Parkinson's Diseases (AD/PD) and vice-versa. We evaluated whether a different distribution of known nongenetic risk factors for cancer and AD/PD, might explain their inverse relationship of occurrence. We nested 2 case-control studies in a subsample of a large cohort of 1,000,000 resident in Lombardy Region in Italy (n=1515), followed-up for cancer and AD/PD occurrence since 1991 until 2012. Conditional logistic regression was performed to determine the odds ratios (OR) and 95% confidence intervals (CI) of AD/PD in subjects with and without cancer and the risk of cancer in those with and without AD/PD...
August 8, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28782481/rational-approaches-design-strategies-structure-activity-relationship-and-mechanistic-insights-for-esterase-inhibitors
#20
Harbinder Singh, Jatinder Vir Singh, Navdeep Kaur, Mohit Sanduja, Gurpreet Singh, Preet Mohinder Singh Bedi, Sahil Sharma
BACKGROUND: Esterase is an enzyme that splits esters into an acid and alcohol. Varieties of esterases are present in human body to control diverse set of cellular processes and execute their specific functions. It can be seen that any increase in metabolites produced by these enzymes lead to severe pathological conditions like Alzheimer disease, hypercholesterolemia etc. OBJECTIVE: Numerous esterase inhibitors have been developed and reported by the researchers around the globe, but not systematically summarized yet...
August 7, 2017: Mini Reviews in Medicinal Chemistry
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