keyword
https://read.qxmd.com/read/38527429/the-intersection-of-epigenetic-alterations-and-developmental-state-in-pediatric-ependymomas
#21
REVIEW
Alisha Simone Kardian, Stephen Mack
BACKGROUND: Ependymomas are the third most common brain cancer in children and have no targeted therapies. They are divided into at least 9 major subtypes based on molecular characteristics and major drivers and have few genetic mutations compared to the adult form of this disease, leading to investigation of other mechanisms. SUMMARY: Epigenetic alterations such as transcriptional programs activated by oncofusion proteins and alterations in histone modifications play an important role in development of this disease...
March 25, 2024: Developmental Neuroscience
https://read.qxmd.com/read/38525788/calling-the-question-what-is-mammalian-transgenerational-epigenetic-inheritance
#22
JOURNAL ARTICLE
Hasan Khatib, Jessica Townsend, Melissa A Konkel, Gabi Conidi, Julia A Hasselkus
While transgenerational epigenetic inheritance has been extensively documented in plants, nematodes, and fruit flies, its existence in mammals remains controversial. Several factors have contributed to this debate, including the lack of a clear distinction between intergenerational and transgenerational epigenetic inheritance (TEI), the inconsistency of some studies, the potential confounding effects of in-utero vs. epigenetic factors, and, most importantly, the biological challenge of epigenetic reprogramming...
December 2024: Epigenetics: Official Journal of the DNA Methylation Society
https://read.qxmd.com/read/38524912/a-systematic-review-of-epigenetics-of-endometriosis
#23
JOURNAL ARTICLE
Bronwyn S Bedrick, Laura Courtright, Jiahui Zhang, Morgan Snow, Isabela Landsteiner Sampaio Amendola, Elisabeth Nylander, Kamaria Cayton-Vaught, James Segars, Bhuchitra Singh
OBJECTIVE: To assess the current literature evaluating the epigenetics of endometriosis in humans. EVIDENCE REVIEW: A systematic review was conducted in accordance with the PRISMA guidelines within PubMed, EBSCOhost, Cochrane Library, Embase, Scopus, and Web of Science Core Collection. A comprehensive search strategy was developed by a data informationist. Observational and interventional studies assessing epigenetics in humans published in English up to January 15th, 2023, were included...
January 2024: F&S reviews
https://read.qxmd.com/read/38522416/recent-developments-in-the-role-of-histone-acetylation-in-asthma
#24
REVIEW
Daniel P Potaczek, Stanisława Bazan-Socha, Ewa Wypasek, Małgorzata Wygrecka, Holger Garn
BACKGROUND: Epigenetic modifications are known to mediate both beneficial and unfavorable effects of environmental exposures on the development and clinical course of asthma. On the molecular level, epigenetic mechanisms participate in multiple aspects of the emerging and ongoing asthma pathology. SUMMARY: Studies performed in the last several years expand our knowledge on the role of histone acetylation, a classical epigenetic mark, in the regulation of (patho)physiological processes of diverse cells playing a central role in asthma, including those belonging to the immune system (e...
March 22, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38522239/research-progress-on-sirtuins-sirts-family-modulators
#25
REVIEW
Mingkai Chen, Junfei Tan, Zihan Jin, Tingting Jiang, Jiabiao Wu, Xiaolong Yu
Sirtuins (SIRTs) represent a class of nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases that exert a crucial role in cellular signal transduction and various biological processes. The mammalian sirtuins family encompasses SIRT1 to SIRT7, exhibiting therapeutic potential in counteracting cellular aging, modulating metabolism, responding to oxidative stress, inhibiting tumors, and improving cellular microenvironment. These enzymes are intricately linked to the occurrence and treatment of diverse pathological conditions, including cancer, autoimmune diseases, and cardiovascular disorders...
March 23, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38522092/sars-cov-2-infection-modifies-the-transcriptome-of-the-megakaryocytes-in-the-bone-marrow
#26
JOURNAL ARTICLE
Isabelle Allaeys, Guillaume Lemaire, Mickael Leclercq, Emile Lacasse, Maude Fleury, Isabelle Dubuc, Leslie Gudimard, Florian Puhm, Julia Tilburg, Andrew P Stone, Kellie R Machlus, Arnaud Droit, Louis Flamand, Eric Boilard
Megakaryocytes, integral to platelet production, predominantly reside in the bone marrow and undergo regulated fragmentation within sinusoid vessels to release platelets into the bloodstream. Inflammatory states and infections influence megakaryocyte transcription, potentially affecting platelet functionality. Notably, COVID-19 has been associated with altered platelet transcriptomes. In this study, we investigated the hypothesis that SARS-CoV-2 infection could impact the transcriptome of bone marrow megakaryocytes...
March 24, 2024: Blood Advances
https://read.qxmd.com/read/38520871/controllers-of-histone-methylation-modifying-enzymes-in-gastrointestinal-cancers
#27
REVIEW
Ling Li, Qing Song, Jing Zhou, Qing Ji
Gastrointestinal (GI) cancers have been considered primarily genetic malignancies, caused by a series of progressive genetic alterations. Accumulating evidence shows that histone methylation, an epigenetic modification program, plays an essential role in the different pathological stages of GI cancer progression, such as precancerous lesions, tumorigenesis, and tumor metastasis. Histone methylation-modifying enzymes, including histone methyltransferases (HMTs) and demethylases (HDMs), are the main executor of post-transcriptional modification...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520556/pharmacology-and-pharmacokinetics-of-tazemetostat
#28
JOURNAL ARTICLE
Marco Orleni, Jan H Beumer
Tazemetostat, a novel oral selective inhibitor of enhancer of zeste homolog 2 (EZH2), was approved by the Food and Drug Administration (FDA) in 2020 for use in patients with advanced epithelioid sarcoma or relapsed/refractory (R/R) EZH2-mutated follicular lymphoma. These indications were approved by the FDA trough accelerated approval based on objective response rate and duration of response that resulted from phase 2 clinical trials. Tazemetostat competes with S-adenosylmethionine (SAM) cofactor to inhibit EZH2, reducing the levels of trimethylated lysine 27 of histone 3 (H3K27me3), considered as pharmacodynamic marker...
March 23, 2024: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/38520216/histone-modification-linked-prognostic-model-for-ovarian-cancer-reveals-lbx2-as-a-novel-growth-promoter
#29
JOURNAL ARTICLE
Jian Xiong, Hongyuan Liang, Xiang Sun, Kefei Gao
Ovarian cancer (OC) is a deadly disease with limited treatment options and poor overall survival rates. This study aimed to investigate the role of histone modification-related genes in predicting the prognosis of OC patients. Transcriptome data from multiple cohorts, including bulk RNA-Seq data and single-cell scRNA-Seq data, were collected. Gene set enrichment analysis was used to identify enriched gene sets in the histone modification pathway. Differentially expressed genes (DEGs) between histone modification-high and histone modification-low groups were identified using Lasso regression...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38517649/the-role-of-h3k27me3-mediated-th17-differentiation-in-ankylosing-spondylitis
#30
JOURNAL ARTICLE
Yuening Chen, Wanlin Liu, Xiaohan Xu, Hongying Zhen, Bo Pang, Zhe Zhao, Yanan Zhao, Hongxiao Liu
Ankylosing spondylitis (AS) is a common chronic progressive inflammatory autoimmune disease. T helper 17 (Th17) cells are the major effector cells mediating AS inflammation. Histone 3 Lys 27 trimethylation (H3K27me3) is an inhibitory histone modification that silences gene transcription and plays an important role in Th17 differentiation. The objective of this study was to investigate the expression of H3K27me3 in patients with AS and to explore its epigenetic regulation mechanism of Th17 differentiation during AS inflammation...
March 22, 2024: Inflammation
https://read.qxmd.com/read/38517373/insight-into-the-complexity-of-male-infertility-a-multi-omics-review
#31
REVIEW
Rebeka Podgrajsek, Alenka Hodzic, Martin Stimpfel, Tanja Kunej, Borut Peterlin
Male infertility is a reproductive disorder, accounting for 40-50% of infertility. Currently, in about 70% of infertile men, the cause remains unknown. With the introduction of novel omics and advancement in high-throughput technology, potential biomarkers are emerging. The main purpose of our work was to overview different aspects of omics approaches in association with idiopathic male infertility and highlight potential genes, transcripts, non-coding RNA, proteins, and metabolites worth further exploring...
December 2024: Systems Biology in Reproductive Medicine
https://read.qxmd.com/read/38516679/effect-of-valproic-acid-on-histone-deacetylase-expression-in-oral-cancer-review
#32
REVIEW
Ahmed S K Al-Khafaji, Lydia M Wang, Haidar H Alabdei, Triantafillos Liloglou
Oral squamous cell carcinoma (OSCC) is a frequent human malignancy that demonstrates a range of genetic and epigenetic alterations. Histone deacetylases (HDACs) are key epigenetic regulators of cell-cycle progression, differentiation and apoptosis and their dysregulation is implicated in cancer development. HDACs are promising targets for anticancer therapy through the utilisation of HDAC inhibitors (HDACis). OSCC cells have been shown to have low levels of histone acetylation, suggesting that HDACis may produce beneficial effects in patients with OSCC...
May 2024: Oncology Letters
https://read.qxmd.com/read/38516554/screening-h3-histone-acetylation-in-a-wild-bird-the-house-sparrow-passer-domesticus
#33
JOURNAL ARTICLE
D Ray, E L Sheldon, C Zimmer, L B Martin, A W Schrey
Epigenetic mechanisms are increasingly understood to have major impacts across ecology. However, one molecular epigenetic mechanism, DNA methylation, currently dominates the literature. A second mechanism, histone modification, is likely important to ecologically relevant phenotypes and thus warrants investigation, especially because molecular interplay between methylation and histone acetylation can strongly affect gene expression. There are a limited number of histone acetylation studies on non-model organisms, yet those that exist show that it can impact gene expression and phenotypic plasticity...
2024: Integrative organismal biology
https://read.qxmd.com/read/38516184/transfer-of-membrane-s-matter-s-non-genetic-inheritance-of-metabolic-phenotypes
#34
JOURNAL ARTICLE
Günter A Müller, Timo D Müller
Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are anchored at the outer phospholipid layer of eukaryotic plasma membranes exclusively by a glycolipid. GPI-APs are not only released into extracellular compartments by lipolytic cleavage. In addition, certain GPI-APs with the glycosylphosphatidylinositol anchor including their fatty acids remaining coupled to the carboxy-terminus of their protein components are also detectable in body fluids, in response to certain stimuli, such as oxidative stress, radicals or high-fat diet...
2024: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38515708/ep300-regulates-the-slc16a1-as1-as1-tcf3-axis-to-promote-lung-cancer-malignancies-through-the-wnt-signaling-pathway
#35
JOURNAL ARTICLE
Yunhao Sun, Jian Sun, Kaijun Ying, Jinjin Chen, Tingting Chen, Leilei Tao, Weigang Bian, Limin Qiu
OBJECTIVE: To investigate the regulatory mechanism of EP300 in the interaction between SLC16A1-AS1 and TCF3 to activate the Wnt pathway, thereby promoting malignant progression in lung cancer. METHODS: In lung cancer cell lines, SLC16A1-AS1 was knocked down, and the impact of this knockdown on the malignant progression of lung cancer cells was assessed through clonogenic assays, Transwell assays, and apoptosis experiments. The regulatory relationship between EP300 and SLC16A1-AS1 was investigated through bioinformatic analysis and ChIP experiments...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38514187/the-rtf1-prf1-dependent-histone-modification-axis-counteracts-multi-drug-resistance-in-fission-yeast
#36
JOURNAL ARTICLE
Jennifer J Chen, Calvin Moy, Viviane Pagé, Cian Monnin, Ziad W El-Hajj, Daina Z Avizonis, Rodrigo Reyes-Lamothe, Jason C Tanny
RNA polymerase II transcription elongation directs an intricate pattern of histone modifications. This pattern includes a regulatory cascade initiated by the elongation factor Rtf1, leading to monoubiquitylation of histone H2B, and subsequent methylation of histone H3 on lysine 4. Previous studies have defined the molecular basis for these regulatory relationships, but it remains unclear how they regulate gene expression. To address this question, we investigated a drug resistance phenotype that characterizes defects in this axis in the model eukaryote Schizosaccharomyces pombe (fission yeast)...
June 2024: Life Science Alliance
https://read.qxmd.com/read/38512451/the-alanyl-trna-synthetase-aars1-moonlights-as-a-lactyl-transferase-to-promote-yap-signaling-in-gastric-cancer
#37
JOURNAL ARTICLE
Junyi Ju, Hui Zhang, Moubin Lin, Zifeng Yan, Liwei An, Zhifa Cao, Dandan Geng, Jingwu Yue, Yang Tang, Luyang Tian, Fan Chen, Yi Han, Wenjia Wang, Shimin Zhao, Jiao Shi, Zhaocai Zhou
Lactylation has been recently identified as a new type of posttranslational modification widely occurring on lysine residues of both histone and non-histone proteins. The acetyl transferase p300 is thought to mediate protein lactylation, yet the cellular concentration of the proposed lactyl-donor, lactyl-coenzyme A is about 1,000 times lower than that of acetyl-CoA, raising the question whether p300 is a genuine lactyl-transferase. Here, we report the Alanyl-tRNA synthetase 1 (AARS1) moonlights as a bona fide lactyl-transferase that directly uses lactate and ATP to catalyze protein lactylation...
March 21, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38512058/dux-activates-metabolism-lactylation-met-network-during-early-ipsc-reprogramming-with-brg1-as-the-histone-lactylation-reader
#38
JOURNAL ARTICLE
Xinglin Hu, Xingwei Huang, Yue Yang, Yuchen Sun, Yanhua Zhao, Zhijing Zhang, Dan Qiu, Yanshuang Wu, Guangming Wu, Lei Lei
The process of induced pluripotent stem cells (iPSCs) reprogramming involves several crucial events, including the mesenchymal-epithelial transition (MET), activation of pluripotent genes, metabolic reprogramming, and epigenetic rewiring. Although these events intricately interact and influence each other, the specific element that regulates the reprogramming network remains unclear. Dux, a factor known to promote totipotency during the transition from embryonic stem cells (ESC) to 2C-like ESC (2CLC), has not been extensively studied in the context of iPSC reprogramming...
March 21, 2024: Nucleic Acids Research
https://read.qxmd.com/read/38511317/mechanisms-of-vascular-inflammation-and-potential-therapeutic-targets-a-position-paper-from-the-esh-working-group-on-small-arteries
#39
REVIEW
Francisco J Rios, Carolina de Ciuceis, Georgios Georgiopoulos, Antonios Lazaridis, Ryszard Nosalski, George Pavlidis, Simon Tual-Chalot, Claudia Agabiti-Rosei, Livia L Camargo, Edyta Dąbrowska, Fosca Quarti-Trevano, Marcin Hellmann, Stefano Masi, Mariarosaria Lopreiato, Georgios Mavraganis, Alessandro Mengozzi, Augusto C Montezano, Konstantinos Stavropoulos, Pawel J Winklewski, Jacek Wolf, Sarah Costantino, Michael Doumas, Eugenia Gkaliagkousi, Guido Grassi, Tomasz J Guzik, Ignatios Ikonomidis, Krzysztof Narkiewicz, Francesco Paneni, Damiano Rizzoni, Kimon Stamatelopoulos, Konstantinos Stellos, Stefano Taddei, Rhian M Touyz, Agostino Virdis
Inflammatory responses in small vessels play an important role in the development of cardiovascular diseases, including hypertension, stroke, and small vessel disease. This involves various complex molecular processes including oxidative stress, inflammasome activation, immune-mediated responses, and protein misfolding, which together contribute to microvascular damage. In addition, epigenetic factors, including DNA methylation, histone modifications, and microRNAs influence vascular inflammation and injury...
March 21, 2024: Hypertension
https://read.qxmd.com/read/38511238/coregulatory-effects-of-multiple-histone-modifications-in-key-ferroptosis-related-genes-for-lung-adenocarcinoma
#40
JOURNAL ARTICLE
Ye-Chen Qi, Hui Bai, Si-Le Hu, Shu-Juan Li, Qian-Zhong Li
Aim: The present study was designed to investigate the coregulatory effects of multiple histone modifications (HMs) on gene expression in lung adenocarcinoma (LUAD). Materials & methods: Ten histones for LUAD were analyzed using ChIP-seq and RNA-seq data. An innovative computational method is proposed to quantify the coregulatory effects of multiple HMs on gene expression to identify strong coregulatory genes and regions. This method was applied to explore the coregulatory mechanisms of key ferroptosis-related genes in LUAD...
March 21, 2024: Epigenomics
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