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https://www.readbyqxmd.com/read/28934836/pregnancy-in-women-with-hypertrophic-cardiomyopathy-data-from-the-european-society-of-cardiology-initiated-registry-of-pregnancy-and-cardiac-disease-ropac
#1
S Goland, I M van Hagen, G Elbaz-Greener, U Elkayam, A Shotan, W M Merz, S C Enar, I R Gaisin, P G Pieper, M R Johnson, R Hall, A Blatt, J W Roos-Hesselink
Aims: We report the maternal and foetal outcomes at birth and after 6 months in a cohort of pregnant women with hypertrophic cardiomyopathy (HCM). Although most women with HCM tolerate pregnancy well, there is an increased risk of obstetric and cardiovascular complications. Methods and results: All pregnant women with HCM entered into the prospective worldwide Registry of Pregnancy and Cardiac disease (ROPAC) were included in this analysis. The primary endpoint was a major adverse cardiovascular event (MACE), which included death, heart failure (HF), thrombo-embolic event, and arrhythmia...
September 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28934680/a-phase-1-study-of-the-janus-kinase-2-jak2-v617f-inhibitor-gandotinib-ly2784544-in-patients-with-primary-myelofibrosis-polycythemia-vera-and-essential-thrombocythemia
#2
Srdan Verstovsek, Ruben A Mesa, Mohamed E Salama, Li Li, Celine Pitou, Fabio P Nunes, Gregory L Price, Jennifer L Giles, Deborah N D'Souza, Richard A Walgren, Josef T Prchal
Mutations in Janus kinase 2 (JAK2) are implicated in the pathogenesis of Philadelphia-chromosome negative myeloproliferative neoplasms, including primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Gandotinib (LY2784544), a potent inhibitor of JAK2 activity, shows increased potency for the JAK2(V617F) mutation. The study had a standard 3+3 dose-escalation design to define the maximum-tolerated dose. Primary objectives were to determine safety, tolerability, and recommended oral daily dose of gandotinib for patients with JAK2(V617F)-positive myelofibrosis, essential thrombocythemia, or polycythemia vera...
August 31, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28934586/improving-student-outcomes-in-higher-education-the-science-of-targeted-intervention
#3
Judith M Harackiewicz, Stacy J Priniski
Many theoretically based interventions have been developed over the past two decades to improve educational outcomes in higher education. Based in social-psychological and motivation theories, well-crafted interventions have proven remarkably effective because they target specific educational problems and the processes that underlie them. In this review, we evaluate the current state of the literature on targeted interventions in higher education with an eye to emerging theoretical and conceptual questions about intervention science...
September 20, 2017: Annual Review of Psychology
https://www.readbyqxmd.com/read/28934457/highly-pathogenic-avian-influenza-a-h5n1-viruses-at-the-animal-human-interface-in-vietnam-2003-2010
#4
Adrian Creanga, Nguyen Le Khanh Hang, Vuong Duc Cuong, Ha T Nguyen, Hoang Vu Mai Phuong, Le Thi Thanh, Nguyen Co Thach, Pham Thi Hien, Nguyen Tung, Yunho Jang, Amanda Balish, Nguyen Hoang Dang, Mai Thuy Duong, Ngo Thu Huong, Do Ngoc Hoa, Nguyen Dang Tho, Alexander Klimov, Bryan K Kapella, Larisa Gubareva, James C Kile, Nguyen Tran Hien, Le Quynh Mai, C Todd Davis
Mutation and reassortment of highly pathogenic avian influenza A(H5N1) viruses at the animal-human interface remain a major concern for emergence of viruses with pandemic potential. To understand the relationship of H5N1 viruses circulating in poultry and those isolated from humans, comprehensive phylogenetic and molecular analyses of viruses collected from both hosts in Vietnam between 2003 and 2010 were performed. We examined the temporal and spatial distribution of human cases relative to H5N1 poultry outbreaks and characterized the genetic lineages and amino acid substitutions in each gene segment identified in humans relative to closely related viruses from avian hosts...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934437/group-b-streptococcus-and-the-vaginal-microbiota
#5
Geoffrey H Rosen, Tara M Randis, Purnahamsi V Desai, Katherine J Sapra, Bing Ma, Pawel Gajer, Michael S Humphrys, Jacques Ravel, Shari E Gelber, Adam J Ratner
Background: Streptococcus agalactiae (group B Streptococcus [GBS]) is an important neonatal pathogen and emerging cause of disease in adults. The major risk factor for neonatal disease is maternal vaginal colonization. However, little is known about the relationship between GBS and vaginal microbiota. Methods: Vaginal lavage samples from nonpregnant women were tested for GBS, and amplicon-based sequencing targeting the 16S ribosomal RNA V3-V4 region was performed...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934356/reducing-cell-wall-feruloylation-by-expression-of-a-fungal-ferulic-acid-esterase-in-festuca-arundinacea-modifies-plant-growth-leaf-morphology-and-the-turnover-of-cell-wall-arabinoxylans
#6
Marcia M de O Buanafina, Prashanti R Iyer, M Fernanda Buanafina, Erica A Shearer
A feature of cell wall arabinoxylan in grasses is the presence of ferulic acid which upon oxidative coupling by the action of peroxidases forms diferuloyl bridges between formerly separated arabinoxylans. Ferulate cross-linking is suspected of playing various roles in different plant processes. Here we investigate the role of cell wall feruloyaltion in two major processes, that of leaf growth and the turnover of cell wall arabinoxylans on leaf senescence in tall fescue using plants in which the level of cell wall ferulates has been reduced by targeted expression of the Aspergillus niger ferulic acid esterase A (FAEA) to the apoplast or Golgi...
2017: PloS One
https://www.readbyqxmd.com/read/28934352/global-reaction-to-the-recent-outbreaks-of-zika-virus-insights-from-a-big-data-analysis
#7
Nicola Luigi Bragazzi, Cristiano Alicino, Cecilia Trucchi, Chiara Paganino, Ilaria Barberis, Mariano Martini, Laura Sticchi, Eugen Trinka, Francesco Brigo, Filippo Ansaldi, Giancarlo Icardi, Andrea Orsi
OBJECTIVE: The recent spreading of Zika virus represents an emerging global health threat. As such, it is attracting public interest worldwide, generating a great amount of related Internet searches and social media interactions. The aim of this research was to understand Zika-related digital behavior throughout the epidemic spreading and to assess its consistence with real-world epidemiological data, using a behavioral informatics and analytics approach. METHODS: In this study, the global web-interest and reaction to the recently occurred outbreaks of the Zika Virus were analyzed in terms of tweets and Google Trends (GT), Google News, YouTube, and Wikipedia search queries...
2017: PloS One
https://www.readbyqxmd.com/read/28933579/innate-immune-cells-for-immunotherapy-of-autoimmune-and-cancer-disorders
#8
Carolina Schäfer, Gabriel Ascui, Carolina H Ribeiro, Mercedes López, Rafael Prados-Rosales, Pablo A González, Susan M Bueno, Claudia A Riedel, Andrés Baena, Alexis M Kalergis, Leandro J Carreño
Modulation of the immune system has been widely targeted for the treatment of several immune-related diseases, such as autoimmune disorders and cancer, due to its crucial role in these pathologies. Current available therapies focus mainly on symptomatic treatment and are often associated with undesirable secondary effects. For several years, remission of disease and subsequently recovery of immune homeostasis has been a major goal for immunotherapy. Most current immunotherapeutic strategies are aimed to inhibit or potentiate directly the adaptive immune response by modulating antibody production and B cell memory, as well as the effector potential and memory of T cells...
September 21, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28933371/the-evolution-of-pediatric-disease-a-moving-target-in-public-health
#9
Mark A Brown
There is a growing threat in the re-emergence of diseases that impact pediatric demographics. While major strides have been made in the field of childhood cancers, there are still more questions than answers. In addition, public resistance to recommended practices related to childhood vaccinations fueled by misinformation has allowed infectious diseases to resurface in developed nations. Meanwhile, climate change and other destabilizing factors are shifting vector populations and driving the emergence of new diseases...
August 31, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28933362/male-infertility-the-effect-of-natural-antioxidants-and-phytocompounds-on-seminal-oxidative-stress
#10
REVIEW
Malik Adewoyin, Muhammad Ibrahim, Ramli Roszaman, Muhammad Lokman Md Isa, Nur Aizura Mat Alewi, Ainin Azwani Abdul Rafa, Mohd Nur Nasyriq Anuar
Defective sperm function has been identified as the most common cause of infertility. The objective of this study was to review recent findings on the effects of various antioxidants on male fertility. High amounts of poly unsaturated fatty acid are found in the mammalian spermatozoa membranes, thereby making them susceptible to lipid peroxidation. Although, free radicals and reactive oxygen species (ROS) play major roles in reproduction, they are strongly associated with oxidative stress. Furthermore, factors such as obesity, inflammation, pollutants and cigarette smoking are negatively correlated with spermatogenesis...
March 1, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28933314/effectiveness-of-a-low-support-remotely-accessible-cognitive-remediation-training-programme-for-chronic-psychosis-cognitive-functional-and-cortical-outcomes-from-a-single-blind-randomised-controlled-trial
#11
G Donohoe, R Dillon, A Hargreaves, O Mothersill, M Castorina, E Furey, A J Fagan, J F Meaney, B Fitzmaurice, B Hallahan, C McDonald, T Wykes, A Corvin, I H Robertson
BACKGROUND: Cognitive remediation (CR) training has emerged as a promising approach to improving cognitive deficits in schizophrenia and related psychosis. The limited availability of psychological services for psychosis is a major barrier to accessing this intervention however. This study investigated the effectiveness of a low support, remotely accessible, computerised working memory (WM) training programme in patients with psychosis. METHODS: Ninety patients were enrolled into a single blind randomised controlled trial of CR...
September 21, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28933075/-key-technologies-in-synthetic-biology-of-natural-products
#12
Xue-Jun Kuang, Li-Qiu Zou, Ying Li, Chao Sun, Shi-Lin Chen
Natural products with complex and diverse structures are the major sources of new drugs. The biosynthesis of natural products is considered to be one of the best ways to solve the problems of complex and scarce natural products. DNA assembly technology and genome editing technology are two key technologies in the emerging interdisciplinary field of synthetic biology. A number of novel DNA assembly methods developed in the last few years have paved the way for the engineering of high molecular weight DNA molecules, including whole genomes, hence, it can realize the reconstruction of the metabolic pathways and speed up optimization process...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28932923/dual-energy-bone-removal-computed-tomography-brct-preliminary-report-of-efficacy-of-acute-intracranial-hemorrhage-detection
#13
Norihito Naruto, Hidenori Tannai, Kazuma Nishikawa, Kentaro Yamagishi, Masahiko Hashimoto, Hideto Kawabe, Yuichi Kamisaki, Hisashi Sumiya, Satoshi Kuroda, Kyo Noguchi
PURPOSE: One of the major applications of dual-energy computed tomography (DECT) is automated bone removal (BR). We hypothesized that the visualization of acute intracranial hemorrhage could be improved on BRCT by removing bone as it has the highest density tissue in the head. This preliminary study evaluated the efficacy of a DE BR algorithm for the head CT of trauma patients. METHODS: Sixteen patients with acute intracranial hemorrhage within 1 day after head trauma were enrolled in this study...
September 20, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28932825/editorial
#14
EDITORIAL
Adrian Saftoiu
Dear colleagues, It is my great pleasure and honor to introduce the September 2017 Issue of Ultrasound International Open (UIO), already in its eight number from the initial appearance of the journal in 2015. Recently, UIO has reached the antechamber of journals applying for Impact Factor, being accepted in ESCI (Emerging Sources Citation Index). Consequently, UIO will soon appear in the Web of Science, a major step forward for the journal. The enthusiasm and hard work of the editors, as well as of the entire Thieme support team was invaluable for this endeavor! Three landmark papers are published in the issue, along with 4 case presentations and 1 letter to the editor...
June 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/28932652/psychosocial-treatment-options-for-major-depressive-disorder-in-older-adults
#15
Brenna N Renn, Patricia A Areán
Late-life depression (LLD) is a public health concern with deleterious effects on overall health, cognition, quality of life, and mortality. Although LLD is relatively common, it is not a normal part of aging and is often under-recognized in older adults. However, psychotherapy is an effective treatment for LLD that aligns with many patients' preferences and can improve health and functioning. This review synthesized the current literature on evidence-based psychotherapies for the treatment of depression in older adults...
March 2017: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/28932302/predictive-value-of-tracheal-rapid-ultrasound-exam-performed-in-the-emergency-department-for-verification-of-tracheal-intubation
#16
Babak Masoumi, Reza Azizkhani, Gilava Hedayati Emam, Morteza Asgarzadeh, Behrouz Zargar Kharazi
BACKGROUND: Verification of the correct placement of the endotracheal tube (ETT) has been one of the most challenging issues of airway management in the field of emergency medicine. Early detection of oesophagal intubation through a reliable method is important for emergency physicians. AIM: The aim of this study was to assess the diagnostic accuracy of tracheal rapid ultrasound exam (TRUE) to assess endotracheal tube misplacement during emergency intubation. METHODS: This was an observational prospective study performed in the emergency department of the major tertiary referral hospital in the city...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28932162/are-nurses-verbally-abused-a-cross-sectional-study-of-nurses-at-a-university-hospital-eastern-province-saudi-arabia
#17
Nouf A Al-Shamlan, Nithya Jayaseeli, Moneera M Al-Shawi, Abdullah S Al-Joudi
BACKGROUND: Workplace violence against health-care workers is a significant problem worldwide. Nurses are at a higher risk of exposure to violence. Studies available in Saudi Arabia are few. OBJECTIVES: The objective of the study was to estimate the prevalence of verbal abuse of nurses at King Fahd Hospital of the University (KFHU) in Khobar, Saudi Arabia, and to identify consequences and the demographic and work-related characteristics associated with it. MATERIALS AND METHODS: This cross-sectional study of 391 nurses by total sample was conducted between November and December 2015, using a modified self-administered questionnaire developed by the World Health Organization...
September 2017: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/28932158/the-burden-perceived-by-informal-caregivers-of-the-elderly-in-saudi-arabia
#18
Sulaiman A Alshammari, Abdullah A Alzahrani, Khaled A Alabduljabbar, Abdulaziz A Aldaghri, Yazeed A Alhusainy, Mohammed A Khan, Rakan A Alshuwaier, Ismail N Kariz
OBJECTIVES: The objective of this study was to discover the characteristics of informal caregivers of elderly patients; to determine the socioeconomic, psychological, and physical consequences facing informal caregivers; and to measure their burdens and needs. MATERIALS AND METHODS: This study was a cross-sectional survey of informal caregivers of elderly patients. Participants were recruited from different hospitals and primary care clinics in Riyadh, Saudi Arabia...
September 2017: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/28931741/major-urinary-protein-levels-are-associated-with-social-status-and-context-in-mouse-social-hierarchies
#19
Won Lee, Amber Khan, James P Curley
We have previously shown that male mice living in groups of 12 males establish and maintain stable linear social hierarchies with each individual having a defined social rank. However, it is not clear which social cues mice use to signal and recognize their relative social status within their hierarchy. In this study, we investigate how individual social status both in pairs and in groups affects the levels of major urinary proteins (MUPs) and specifically MUP20 in urine. We housed groups of adult outbred CD1 male mice in a complex social environment for three weeks and collected urine samples from all individuals repeatedly...
September 27, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28931688/a-selective-bottleneck-shapes-the-evolutionary-mutant-spectra-of-enterovirus-a71-during-viral-dissemination-in-humans
#20
Sheng-Wen Huang, Yi-Hui Huang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Jen-Ren Wang
RNA viruses accumulate mutations to rapidly adapt to environmental changes. Enterovirus A71 (EV-A71) causes various clinical manifestations with occasional severe neurological complications. However, the mechanism by which EV-A71 evolves within the human body is unclear. Utilizing deep sequencing and haplotype analyses of viruses from various tissues of an autopsy patient, we sought to define the evolutionary pathway by which enterovirus A71 evolves fitness for invading the central nervous system in humans...
September 20, 2017: Journal of Virology
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