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https://www.readbyqxmd.com/read/28231682/unmet-needs-of-the-patients-with-obsessive-compulsive-disorder
#1
(no author information available yet)
BACKGROUND: Obsessive compulsive disorder (OCD) is a disabling mental disorder with the chronic and difficult course. The disorder is accompanied by numerous limitations in personal and interpersonal functioning. OCD decreases the quality of life and the chance to maintain relationships and professional status. The patients with OCD often experience a severe disabling course of the disorder. Even the individuals, who follow treatment advice, are often still highly symptomatic. In the last decade, the concept of the needs has been assessed as an extent of the traditional outcome evaluation in order to focus on the identification of the specific needs of the patients and their relatives, improve the patients´ overall mental condition and quality of life, and also to increase the treatment effectiveness of the mental disorders...
October 24, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28231416/feasibility-of-combining-common-data-elements-across-studies-to-test-a-hypothesis
#2
Elizabeth J Corwin, Shirley M Moore, Andrea Plotsky, Margaret M Heitkemper, Susan G Dorsey, Drenna Waldrop-Valverde, Donald E Bailey, Sharron L Docherty, Joanne D Whitney, Carol M Musil, Cynthia M Dougherty, Donna J McCloskey, Joan K Austin, Patricia A Grady
PURPOSE: The purpose of this article is to describe the outcomes of a collaborative initiative to share data across five schools of nursing in order to evaluate the feasibility of collecting common data elements (CDEs) and developing a common data repository to test hypotheses of interest to nursing scientists. This initiative extended work already completed by the National Institute of Nursing Research CDE Working Group that successfully identified CDEs related to symptoms and self-management, with the goal of supporting more complex, reproducible, and patient-focused research...
February 23, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28231331/mesenchymal-stromal-cells-mscs-induce-ex-vivo-proliferation-and-erythroid-commitment-of-cord-blood-haematopoietic-stem-cells-cb-cd34-cells
#3
Simone Perucca, Andrea Di Palma, Pier Paolo Piccaluga, Claudia Gemelli, Elisa Zoratti, Giulio Bassi, Edoardo Giacopuzzi, Andrea Lojacono, Giuseppe Borsani, Enrico Tagliafico, Maria Teresa Scupoli, Simona Bernardi, Camilla Zanaglio, Federica Cattina, Valeria Cancelli, Michele Malagola, Mauro Krampera, Mirella Marini, Camillo Almici, Sergio Ferrari, Domenico Russo
A human bone marrow-derived mesenchymal stromal cell (MSCs) and cord blood-derived CD34+ stem cell co-culture system was set up in order to evaluate the proliferative and differentiative effects induced by MSCs on CD34+ stem cells, and the reciprocal influences on gene expression profiles. After 10 days of co-culture, non-adherent (SN-fraction) and adherent (AD-fraction) CD34+ stem cells were collected and analysed separately. In the presence of MSCs, a significant increase in CD34+ cell number was observed (fold increase = 14...
2017: PloS One
https://www.readbyqxmd.com/read/28231313/a-stochastic-hybrid-systems-based-framework-for-modeling-dependent-failure-processes
#4
Mengfei Fan, Zhiguo Zeng, Enrico Zio, Rui Kang, Ying Chen
In this paper, we develop a framework to model and analyze systems that are subject to dependent, competing degradation processes and random shocks. The degradation processes are described by stochastic differential equations, whereas transitions between the system discrete states are triggered by random shocks. The modeling is, then, based on Stochastic Hybrid Systems (SHS), whose state space is comprised of a continuous state determined by stochastic differential equations and a discrete state driven by stochastic transitions and reset maps...
2017: PloS One
https://www.readbyqxmd.com/read/28231148/potential-use-of-gamma-irradiated-ethnic-ready-to-eat-foods-to-improve-the-nutritional-status-of-landslide-victims
#5
REVIEW
Zubaidah Irawati Koenari, Carmen M Siagian, Bona Simanungkalit, Asti Nilatany, Indra Mustika Pratama, Deudeu Lasmawati, Cecep M Nurcahya
The safety and high quality of ethnic ready-to-eat foods as a source of nourishment and food supplies chain to the remote areas become particularly important. Consuming healthy and balanced nutritional foods means eating better quality foods in proper quantities. Such foods can be developed through a preservation technique by using ionizing radiation. Although implementation of the technology for certain foodstuffs has been implemented in some countries, application of the process to a complete set of meals for selected target groups is still very limited...
July 26, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230869/a-combined-high-temperature-experimental-and-theoretical-kinetic-study-of-the-reaction-of-dimethyl-carbonate-with-oh-radicals
#6
Fethi Khaled, Binod Raj Giri, Milán Szőri, Tam V-T Mai, Lam K Huynh, Aamir Farooq
The reaction kinetics of dimethyl carbonate (DMC) and OH radicals were investigated behind reflected shock waves over the temperature range of 872-1295 K and at pressures near 1.5 atm. Reaction progress was monitored by detecting OH radicals at 306.69 nm using a UV laser absorption technique. The rate coefficients for the reaction of DMC with OH radicals were extracted using a detailed kinetic model developed by Glaude et al. (Proc. Combust. Inst. 2005, 30(1), 1111-1118). The experimental rate coefficients can be expressed in Arrhenius form as: kexpt'l = 5...
February 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28230529/single-molecule-fret-unveils-induced-fit-mechanism-for-substrate-selectivity-in-flap-endonuclease-1
#7
Fahad Rashid, Paul D Harris, Manal S Zaher, Mohamed A Sobhy, Luay I Joudeh, Chunli Yan, Hubert Piwonski, Susan E Tsutakawa, Ivaylo Ivanov, John A Tainer, Satoshi Habuchi, Samir M Hamdan
Human flap endonuclease 1 (FEN1) and related structure-specific 5'nucleases precisely identify and incise aberrant DNA structures during replication, repair and recombination to avoid genomic instability. Yet, it is unclear how the 5'nuclease mechanisms of DNA distortion and protein ordering robustly mediate efficient and accurate substrate recognition and catalytic selectivity. Here, single-molecule sub-millisecond and millisecond analyses of FEN1 reveal a protein-DNA induced-fit mechanism that efficiently verifies substrate and suppresses off-target cleavage...
February 23, 2017: ELife
https://www.readbyqxmd.com/read/28230440/late-gastrointestinal-effects-of-pelvic-radiation-a-nurse-led-service
#8
Helen Ludlow, John Green, Jeff Turner
There are currently at least 2 million people in the UK living with and following a cancer diagnosis. Typically four out of every ten people with cancer will receive radiotherapy, but a large proportion of people who have pelvic radiotherapy may go on to develop gastrointestinal (GI) symptoms. This includes rectal bleeding and faecal incontinence, which can have a huge impact on quality of life. These problems often go under-reported by patients and are also under-recognised or under-treated by health professionals...
February 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28230325/serum-phosphatidylinositol-as-a-biomarker-for-bipolar-disorder-liability
#9
Emma Em Knowles, Peter J Meikle, Kevin Huynh, Harald Hh Göring, Rene L Olvera, Samuel R Mathias, Ravi Duggirala, Laura Almasy, John Blangero, Joanne E Curran, David C Glahn
OBJECTIVES: Individuals with bipolar disorder (BPD) exhibit alterations in their phospholipid levels. It is unclear whether these alterations are a secondary consequence of illness state, or if phospholipids and illness risk overlap genetically. If the latter were true, then phospholipids might provide key insights into the pathophysiology of the illness. Therefore, we rank-ordered phospholipid classes by their genetic overlap with BPD risk in order to establish which class might be most informative in terms of increasing our understanding of illness pathophysiology...
February 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28230265/spatial-optimization-of-future-urban-development-with-regards-to-climate-risk-and-sustainability-objectives
#10
Daniel Caparros-Midwood, Stuart Barr, Richard Dawson
Future development in cities needs to manage increasing populations, climate-related risks, and sustainable development objectives such as reducing greenhouse gas emissions. Planners therefore face a challenge of multidimensional, spatial optimization in order to balance potential tradeoffs and maximize synergies between risks and other objectives. To address this, a spatial optimization framework has been developed. This uses a spatially implemented genetic algorithm to generate a set of Pareto-optimal results that provide planners with the best set of trade-off spatial plans for six risk and sustainability objectives: (i) minimize heat risks, (ii) minimize flooding risks, (iii) minimize transport travel costs to minimize associated emissions, (iv) maximize brownfield development, (v) minimize urban sprawl, and (vi) prevent development of greenspace...
February 23, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28229848/-the-extraction-non-extraction-dilemma-a-case-in-the-border
#11
José Chaqués-Asensi
INTRODUCTION: The extraction-non extraction dilemma is a classic one in the history of orthodontics [2, 19, 30]. In some cases the decision seems to be very clear whereas in some others discrepancies among clinicians can easily be found. Different authors propose different protocols in order to decide whether extractions are necessary in a particular clinical situation. In the last 25 years, the debate has been reframed with new non-extractionists trends based on new treatment philosophies or mechanics...
March 2017: L' Orthodontie Française
https://www.readbyqxmd.com/read/28229478/students-experiences-of-role-relationships-and-learning-in-two-clerkship-models
#12
D Jill Konkin, Carol Suddards
CONTEXT: An increasing number of medical schools around the world are implementing longitudinal integrated clerkships (LICs). The University of Alberta's third-year LIC admits a small group of each class. Those not in the LIC undertake a rotation-based clerkship (RBC). All students have a fourth-year RBC. Meaningful participation in patient care and guidance have been identified as affordances for work-based learning. METHODS: This qualitative study is part of an ongoing research programme conducted in a hermeneutic phenomenological frame...
February 22, 2017: Medical Education
https://www.readbyqxmd.com/read/28229338/investigation-of-the-encapsulation-of-metal-cations-cu-2-zn-2-ca-2-and-ba-2-by-the-dipeptide-phe-phe-using-natural-bond-orbital-theory-and-molecular-dynamics-simulation
#13
Snehasis Bhunia, Ajeet Singh, Animesh K Ojha
Complexes of the dipeptide phenylalanine-phenylalanine (Phe-Phe) with divalent metal cations (Cu(2+), Zn(2+), Ca(2+) and Ba(2+)) were studied at the B3LYP and MP2 levels of theory with the basis sets 6-311++G(d,p) and 6-31 + G(d) in the gas phase. The relative energies of these complexes indicated that cation-π bidentate/tridentate conformations are more favourable than other conformations with uncoordinated rings. These findings were confirmed by the calculated values of thermodynamic parameters such as the Gibbs free energy...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28228230/expanding-professional-pharmacy-services-in-european-community-setting-is-it-cost-effective-a-systematic-review-for-health-policy-considerations
#14
REVIEW
Clémence Perraudin, Olivier Bugnon, Nathalie Pelletier-Fleury
OBJECTIVE: To synthesize cost-effectiveness analyses on professional pharmacy services (PPS) performed in Europe in order to contribute to current debates on their funding and reimbursement. METHODS: Systematic review in PubMed, Embase and the Centre for Reviews and Dissemination databases to identify full economic evaluation studies of PPS in community setting from 2004. FINDINGS: Twenty-one studies were included, conducted in the United-Kingdom (n=13), the Netherlands (n=3), Spain (n=2), Belgium (n=1), France (n=1) and Denmark (n=1)...
December 2016: Health Policy
https://www.readbyqxmd.com/read/28227993/modeling-fiber-like-conductivity-structures-via-the-boundary-element-method-using-thin-wire-approximation-i-construction-of-basis-functions
#15
Sergey N Makarov, Alvaro Pascual-Leone, Aapo Nummenmaa, Sergey N Makarov, Alvaro Pascual-Leone, Aapo Nummenmaa, Aapo Nummenmaa, Sergey N Makarov, Alvaro Pascual-Leone
A set of one-dimensional basis functions is proposed and tested in order to model a thin homogeneous fiber of a higher conductivity within a medium with a lower conductivity. This set allows us to greatly speed up computations while keeping a good accuracy for the total fiber current and the resulting charge distribution averaged over the fiber cross-section.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227924/a-hybrid-hardware-and-software-approach-for-cancelling-stimulus-artifacts-during-same-electrode-neural-stimulation-and-recording
#16
Stanislav Culaclii, Brian Kim, Yi-Kai Lo, Wentai Liu, Stanislav Culaclii, Brian Kim, Yi-Kai Lo, Wentai Liu, Brian Kim, Yi-Kai Lo, Wentai Liu, Stanislav Culaclii
Recovering neural responses from electrode recordings is fundamental for understanding the dynamics of neural networks. This effort is often obscured by stimulus artifacts in the recordings, which result from stimuli injected into the electrode-tissue interface. Stimulus artifacts, which can be orders of magnitude larger than the neural responses of interest, can mask short-latency evoked responses. Furthermore, simultaneous neural stimulation and recording on the same electrode generates artifacts with larger amplitudes compared to a separate electrode setup, which inevitably overwhelm the amplifier operation and cause unrecoverable neural signal loss...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227851/design-and-validation-of-a-high-order-weighted-frequency-fourier-linear-combiner-based-kalman-filter-for-parkinsonian-tremor-estimation
#17
Y Zhou, M E Jenkins, M D Naish, A L Trejos, Y Zhou, M E Jenkins, M D Naish, A L Trejos, M E Jenkins, M D Naish, Y Zhou, A L Trejos
The design of a tremor estimator is an important part of designing mechanical tremor suppression orthoses. A number of tremor estimators have been developed and applied with the assumption that tremor is a mono-frequency signal. However, recent experimental studies have shown that Parkinsonian tremor consists of multiple frequencies, and that the second and third harmonics make a large contribution to the tremor. Thus, the current estimators may have limited performance on estimation of the tremor harmonics...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227836/exerciser-for-rehabilitation-of-the-arm-era-development-and-unique-features-of-a-3d-end-effector-robot
#18
Marie-Helene Milot, Mathieu Hamel, Philippe-Olivier Provost, Julien Bernier-Ouellet, Maxime Dupuis, Dominic Letourneau, Simon Briere, Francois Michaud, Marie-Helene Milot, Mathieu Hamel, Philippe-Olivier Provost, Julien Bernier-Ouellet, Maxime Dupuis, Dominic Letourneau, Simon Briere, Francois Michaud, Philippe-Olivier Provost, Dominic Letourneau, Maxime Dupuis, Marie-Helene Milot, Francois Michaud, Mathieu Hamel, Julien Bernier-Ouellet, Simon Briere
Stroke is one of the leading causes of disability worldwide. Consequently, many stroke survivors exhibit difficulties undergoing voluntary movement in their affected upper limb, compromising their functional performance and level of independence. To minimize the negative impact of stroke disabilities, exercises are recognized as a key element in post-stroke rehabilitation. In order to provide the practice of exercises in a uniform and controlled manner as well as increasing the efficiency of therapists' interventions, robotic training has been found, and continues to prove itself, as an innovative intervention for post-stroke rehabilitation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227782/predicting-short-term-icu-outcomes-using-a-sequential-contrast-motif-based-classification-framework
#19
Shameek Ghosh, Hung Nguyen, Jinyan Li, Shameek Ghosh, Hung Nguyen, Jinyan Li, Shameek Ghosh, Hung Nguyen, Jinyan Li
Critical ICU events like acute hypotension and septic shock are dangerous complications, leading to multiple organ failures and eventual death. Previously, pattern mining algorithms have been employed for extracting interesting rules in various clinical domains. However, the extracted rules are directly investigated by clinicians for diagnosing a disease. Towards this purpose, there is a need to develop advanced prediction models which integrate dynamic patterns to learn a patient's physiological condition...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227635/identifying-the-number-and-location-of-body-worn-sensors-to-accurately-classify-walking-transferring-and-sedentary-activities
#20
Omar Aziz, Stephen N Robinovitch, Edward J Park, Omar Aziz, Stephen N Robinovitch, Edward J Park, Omar Aziz, Edward J Park, Stephen N Robinovitch
In order to perform fall risk assessments using wearable inertial sensors in older adults in their natural settings where falls are likely to occur, a first step is to automatically segment and classify sensor signals of human movements into the known `activities of interest'. Sensor data from such activities can later be used through quantitative and qualitative analysis for differentiating fallers from non-fallers. In this study, ten young adults participated in experimental trials involving several variations of walking, transferring and sedentary activities...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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