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https://www.readbyqxmd.com/read/29040634/implementation-of-acute-care-patient-portals-recommendations-on-utility-and-use-from-six-early-adopters
#1
Lisa V Grossman, Sung W Choi, Sarah Collins, Patricia C Dykes, Kevin J O'Leary, Milisa Rizer, Philip Strong, Po-Yin Yen, David K Vawdrey
Objective: To provide recommendations on how to most effectively implement advanced features of acute care patient portals, including: (1) patient-provider communication, (2) care plan information, (3) clinical data viewing, (4) patient education, (5) patient safety, (6) caregiver access, and (7) hospital amenities. Recommendations: We summarize the experiences of 6 organizations that have implemented acute care portals, representing a variety of settings and technologies...
September 4, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29040331/primary-care-models-for-treating-opioid-use-disorders-what-actually-works-a-systematic-review
#2
Pooja Lagisetty, Katarzyna Klasa, Christopher Bush, Michele Heisler, Vineet Chopra, Amy Bohnert
BACKGROUND: Primary care-based models for Medication-Assisted Treatment (MAT) have been shown to reduce mortality for Opioid Use Disorder (OUD) and have equivalent efficacy to MAT in specialty substance treatment facilities. OBJECTIVE: The objective of this study is to systematically analyze current evidence-based, primary care OUD MAT interventions and identify program structures and processes associated with improved patient outcomes in order to guide future policy and implementation in primary care settings...
2017: PloS One
https://www.readbyqxmd.com/read/29040288/music-viewed-by-its-entropy-content-a-novel-window-for-comparative-analysis
#3
Gerardo Febres, Klaus Jaffe
Polyphonic music files were analyzed using the set of symbols that produced the Minimal Entropy Description, which we call the Fundamental Scale. This allowed us to create a novel space to represent music pieces by developing: (a) a method to adjust a textual description from its original scale of observation to an arbitrarily selected scale, (b) a method to model the structure of any textual description based on the shape of the symbol frequency profiles, and (c) the concept of higher order entropy as the entropy associated with the deviations of a frequency-ranked symbol profile from a perfect Zipfian profile...
2017: PloS One
https://www.readbyqxmd.com/read/29040278/pg-metrics-a-chemometric-based-approach-for-classifying-bacterial-peptidoglycan-data-sets-and-uncovering-their-subjacent-chemical-variability
#4
Keshav Kumar, Akbar Espaillat, Felipe Cava
Bacteria cells are protected from osmotic and environmental stresses by an exoskeleton-like polymeric structure called peptidoglycan (PG) or murein sacculus. This structure is fundamental for bacteria's viability and thus, the mechanisms underlying cell wall assembly and how it is modulated serve as targets for many of our most successful antibiotics. Therefore, it is now more important than ever to understand the genetics and structural chemistry of the bacterial cell walls in order to find new and effective methods of blocking it for the treatment of disease...
2017: PloS One
https://www.readbyqxmd.com/read/29040063/validation-of-the-six-sigma-z-score-for-the-quality-assessment-of-clinical-laboratory-timeliness
#5
Cristiano Ialongo, Sergio Bernardini
BACKGROUND: The International Federation of Clinical Chemistry and Laboratory Medicine has introduced in recent times the turnaround time (TAT) as mandatory quality indicator for the postanalytical phase. Classic TAT indicators, namely, average, median, 90th percentile and proportion of acceptable test (PAT), are in use since almost 40 years and to date represent the mainstay for gauging the laboratory timeliness. In this study, we investigated the performance of the Six Sigma Z-score, which was previously introduced as a device for the quantitative assessment of timeliness...
October 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29036819/age-and-graphomotor-decision-making-assessed-with-the-digital-clock-drawing-test-the-framingham-heart-study
#6
Ryan J Piers, Kathryn N Devlin, Boting Ning, Yulin Liu, Ben Wasserman, Joseph M Massaro, Melissa Lamar, Catherine C Price, Rod Swenson, Randall Davis, Dana L Penney, Rhoda Au, David J Libon
BACKGROUND: Digital Clock Drawing Test (dCDT) technology enables the examination of detailed neurocognitive behavior as behavior unfolds in in real time; a capability that cannot be obtained using a traditional pen and paper testing format. OBJECTIVE: Parameters obtained from the dCDT were used to investigate neurocognitive constructs related to higher-order neurocognitive decision-making and information processing speed. The current research sought to determine the effect of age as related to combined motor and non-motor components of drawing, and higher-order, decision-making latencies...
October 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036516/a-two-stage-approach-of-gene-network-analysis-for-high-dimensional-heterogeneous-data
#7
Sangin Lee, Faming Liang, Ling Cai, Guanghua Xiao
Gaussian graphical models have been widely used to construct gene regulatory networks from gene expression data. Most existing methods for Gaussian graphical models are designed to model homogeneous data, assuming a single Gaussian distribution. In practice, however, data may consist of gene expression studies with unknown confounding factors, such as study cohort, microarray platforms, experimental batches, which produce heterogeneous data, and hence lead to false positive edges or low detection power in resulting network, due to those unknown factors...
July 18, 2017: Biostatistics
https://www.readbyqxmd.com/read/29036051/combined-measurement-system-for-double-shield-tunnel-boring-machine-guidance-based-on-optical-and-visual-methods
#8
Jiarui Lin, Kai Gao, Yang Gao, Zheng Wang
In order to detect the position of the cutting shield at the head of a double shield tunnel boring machine (TBM) during the excavation, this paper develops a combined measurement system which is mainly composed of several optical feature points, a monocular vision sensor, a laser target sensor, and a total station. The different elements of the combined system are mounted on the TBM in suitable sequence, and the position of the cutting shield in the reference total station frame is determined by coordinate transformations...
October 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29036049/partially-coherent-vortex-beams-of-arbitrary-order
#9
C S D Stahl, G Gbur
We derive analytic solutions for an infinite set of partially coherent vortex beams (PCVBs) of any azimuthal order and for any propagation distance. The correlation singularities of the beams and their orbital angular momentum are investigated. This detailed study of PCVBs opens the possibility of using such beams for remote sensing and free-space optical communications.
October 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035967/pediatric-clinical-handover-a-best-practice-implementation-project
#10
Zhuowen Yu, Yuxia Zhang, Ying Gu, Xiaofeng Xu, Alexa McArthur
BACKGROUND: Communication of information between and among healthcare providers is an essential element of patient care. Poor clinical handover has been associated with inaccurate clinical assessment and diagnosis, delays in diagnosis, medication errors and decreased patient satisfaction. Effective and efficient transition of patient care information requires an evidence-based handover approach. OBJECTIVES: The aim of this evidence implementation project was to make a contribution to promote evidence-based practice in clinical handover in a pediatric setting and thereby enhance patient safety and service delivery...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035964/medication-safety-programs-in-primary-care-a-scoping-review
#11
Hanan Khalil, Monica Shahid, Libby Roughead
BACKGROUND: Medication safety plays an essential role in all healthcare organizations; improving this area is paramount to quality and safety of any wider healthcare program. While several medication safety programs in the hospital setting have been described and the associated impact on patient safety evaluated, no systematic reviews have described the impact of medication safety programs in the primary care setting. A preliminary search of the literature demonstrated that no systematic reviews, meta-analysis or scoping reviews have reported on medication safety programs in primary care; instead they have focused on specific interventions such as medication reconciliation or computerized physician order entry...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035820/real-time-monitoring-of-amyloid-fibrillation-by-electrical-impedance-spectroscopy
#12
Rafael R da Silva, Sandro V de Lima, Helinando P de Oliveira, Celso P de Melo, Isaac A M Frías, Maria D L Oliveira, César A S Andrade
Electrical impedance spectroscopy (EIS) appears a promising label-free methodology for the investigation of processes related to the aggregation of macromolecules in solution. Here, we explore the EIS technique as a convenient tool for studying the irreversible aggregation of human insulin and describing its corresponding fibrillation kinetics. The in situ measurement of the electrical response of pure insulin solutions at 60°C allows for the real-time monitoring of the protein fibrillation as a function of the incubation time...
October 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29035811/moving-towards-fast-characterization-of-polymorphic-drugs-by-solid-state-nmr-spectroscopy
#13
Rosalynn Quiñones, Robbie J Iuliucci, Grayce Behnke, Ryanne Brown, Deben Shoup, Taylor M Riedel, Christine Plavchak, Brooke E Lininger, Jonathan M Spehar
Solid-state nuclear magnetic resonance (SS-NMR) spectroscopy has become a common technique to study polymorphism in pharmaceutical solids at high-resolution. However, high-throughput application of high resolution SS-NMR spectroscopy is severely limited by the long (1)H spin-lattice relaxation (T1) that is common to solid phase compounds. Here, we demonstrate the use of paramagnetic relaxation reagents such as chromium (III) acetylacetonate (Cr(acac)3) and nickel (II) acetylacetonate (Ni(acac)2) for fast data acquisition by significantly reducing the T1 value for carbamazepine Forms I, II, III, and dihydrate, cimetidine Forms A and B, nabumetone Form I, and acetaminophen Form I polymorphs...
October 3, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29035675/practical-considerations-in-clinical-strategy-to-support-the-development-of-injectable-drug-device-combination-products-for-biologics
#14
Zhaoyang Li, Rachael Easton
The development of an injectable drug-device combination (DDC) product for biologics is an intricate and evolving process that requires substantial investments of time and money. Consequently, the commercial dosage form(s) or presentation(s) are often not ready when pivotal trials commence, and it is common to have drug product changes (manufacturing process or presentation) during clinical development. A scientifically sound and robust bridging strategy is required in order to introduce these changes into the clinic safely...
October 16, 2017: MAbs
https://www.readbyqxmd.com/read/29035638/evaluation-of-the-effectiveness-of-a-novel-gait-trainer-in-increasing-the-functionality-of-individuals-with-motor-impairment-a-case-series
#15
Eitan Raveh, Isabella Schwartz, Naama Karniel, Sigal Portnoy
Regaining the ability to independently ambulate following a physical disability can increase functional ability and participation of patients in daily life. Gait trainers are assistive devices that enable body support and provide safety during gait. However, most conventional gait trainers are pre-configured to a constant position, therefore not suitable for practicing sit-to-stand function, and require assistance from a caregiver in order to mount the device from a sitting position. We therefore evaluated the effectiveness of a dynamically-adjusting gait trainer, designed to provide independence and safety during gait and various activities, in both lab setting and at home in 4 subjects (1 female, 3 males, ages 32-79 years) with limited ambulation...
October 16, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/29035631/bioconcentration-and-half-life-of-quinalphos-pesticide-in-rice-fish-integration-system-in-the-mekong-delta-vietnam
#16
Nguyen Quoc Thinh, Tran Minh Phu, Caroline Douny, Nguyen Thanh Phuong, Do Thi Thanh Huong, Patrick Kestemont, Marie-Louise Scippo
In order to determine the distribution and enable the elimination of quinalphos, a popular active pesticide compound used in the Mekong Delta, an experiment was set up in a rice-fish integration system in Can Tho City, Vietnam. Fish was stocked into the field when the rice was two-months old. Quinalphos was applied twice in doses of 42.5 g per 1000 m(2). Water, fish and sediment samples were collected at time intervals and analyzed by a Gas Chromatography Electron Capture Detector system. The results show that quinalphos residues in fish muscles were much higher than those of the water and the bioconcentration factor (logBCF) was above 2 for the fish...
October 16, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/29035607/accuracy-of-w-recovery-kinetics-in-high-performance-cyclists-modelling-intermittent-work-capacity
#17
Jason C Bartram, Dominic Thewlis, David T Martin, Kevin I Norton
PURPOSE: With knowledge of an individual's critical power (CP) and W' the SKIBA 2 model provides a framework with which to track W' balance during intermittent high intensity work bouts. There are fears the time constant controlling the recovery rate of W' (τW') may require refinement to enable effective use in an elite population. METHODS: Four elite endurance cyclists completed an array of intermittent exercise protocols to volitional exhaustion. Each protocol lasted approximately 3...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29035570/a-median-solver-and-phylogenetic-inference-based-on-double-cut-and-join-sorting
#18
Ruofan Xia, Yu Lin, Jun Zhou, Bing Feng, Jijun Tang
Genome rearrangement is known as one of the main evolutionary mechanisms on the genomic level. Phylogenetic analysis based on rearrangement played a crucial role in biological research in the past decades, especially with the increasing availability of fully sequenced genomes. In general, phylogenetic analysis aims to solve two problems: small parsimony problem (SPP) and big parsimony problem (BPP). Maximum parsimony is a popular approach for SPP and BPP, which relies on iteratively solving an NP-hard problem, the median problem...
October 16, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29035245/in-vivo-and-in-vitro-models-for-scanning-drug-substances-in-malaria-prestudy
#19
Ahmet Özbilgin, İbrahim Çavuş, Alicem Nuraydın, Tuğba Kaya
OBJECTIVE: The Wolrd Health Organization (WHO) encourages all countries to investigate antimalarial drug substances derived from herbal sources with the slogan "Hunt of the Next Artemisinin" due to the emergence of resistant strains of Plasmodium species to artemisinin. In the broad and simple sense, it was planned to help guide the young researchers set in-vitro and in-vivo models of malaria in order to be used in drug research and active ingredient studies. METHODS: In-vitro study, young Plasmodium berghei trophozoites were removed from the liquid nitrogen tank and resuspended in appropriate conditions, followed by incubation with chloroquine and tetracycline at concentrations of 0...
September 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29034828/professional-expertise-amongst-speech-language-therapists-willing-to-share
#20
Bianca N Jackson, Suzanne Carolyn Purdy, Helena Cooper-Thomas
Purpose The current healthcare environment provides several challenges to the existing roles of healthcare professionals. The value of the professional expert is also under scrutiny. The purpose of this paper is to generate a construction of professional expertise amongst practitioners in the current healthcare environment. It used the speech-language therapy community in New Zealand (NZ) as an example. Design/methodology/approach Speech-language therapists currently practicing in NZ completed an online survey including qualitative and quantitative components...
September 18, 2017: Journal of Health Organization and Management
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