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https://www.readbyqxmd.com/read/28529973/high-affinity-mannotetraose-as-an-alternative-to-dextran-in-cona-based-fluorescent-affinity-glucose-assay-due-to-improved-fret-efficiency
#1
Andrea K Locke, Brian M Cummins, Gerard L Coté
Diabetes mellitus affects millions of people worldwide and requires that individuals tightly self-regulate their blood glucose levels to minimize the associated secondary complications. Continuous monitoring devices potentially offer patients a long-term means to tightly monitor their glucose levels. In recent years, fluorescent affinity sensors based on lectins (e.g., Concanavalin A (ConA)) have been implemented in such devices. Traditionally, these sensors pair the lectin with a multivalent ligand, like dextran, in order to develop a competitive binding assay that changes its fluorescent properties in response to the surrounding glucose concentrations...
May 27, 2016: ACS Sensors
https://www.readbyqxmd.com/read/28529910/generalizable-items-of-quantitative-and-qualitative-cornerstones-for-personnel-requirement-of-physicians-in-anesthesia
#2
REVIEW
Manfred Weiss, Rolf Rossaint, Thomas Iber
Anesthesiologists perform a broad spectrum of tasks. However, in many countries, there is no legal basis for personnel staffing of physicians in anesthesia. Also, the German diagnosis related groups system for refunding does not deliver such a basis. Thus, in 2006 a new calculation base for the personnel requirement that included an Excel calculation sheet was introduced by the German Board of Anesthesiologists (BDA) and the German Society of Anesthesiology and Intensive Care Medicine (DGAI), and updated in 2009 and 2015...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28523960/the-health-literacy-dyad-the-contribution-of-future-gps-in-england
#3
Oana R Groene, Jane Wills, Nicola Crichton, Gill Rowlands, Rima R Rudd
BACKGROUND: Health literacy studies have primarily focused on the cognitive and social skills of individuals needed to gain access to, understand, and use health information. This area of study is undergoing a paradigm shift with increased attention being paid to the skills of practitioners and an examination of their contribution to the link between literacy and health outcomes. The aim of this study was to describe the health literacy related competencies of General Practice (GP) trainees who will soon be responsible for the clinical encounter...
May 19, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28520978/ldb1-mediated-enhancer-looping-can-be-established-independent-of-mediator-and-cohesin
#4
Ivan Krivega, Ann Dean
Mechanistic studies in erythroid cells indicate that LDB1, as part of a GATA1/TAL1/LMO2 complex, brings erythroid-expressed genes into proximity with enhancers for transcription activation. The role of co-activators in establishing this long-range interaction is poorly understood. Here we tested the contributions of the RNA Pol II pre-initiation complex (PIC), mediator and cohesin to establishment of locus control region (LCR)/β-globin proximity. CRISPR/Cas9 editing of the β-globin promoter to eliminate the RNA Pol II PIC by deleting the TATA-box resulted in loss of transcription, but enhancer-promoter interaction was unaffected...
May 18, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28511787/comparative-and-cost-effectiveness-research-competencies-opportunities-and-training-for-nurse-scientists
#5
Patricia W Stone, Catherine Cohen, Harold Alan Pincus
BACKGROUND: Comparative and cost-effectiveness research develops knowledge on the everyday effectiveness and value of treatments and care delivery models. PURPOSE: To describe comparative and cost-effectiveness research; identify needed competencies for this research; identify federal funding; and describe current training opportunities. METHODS: Published recommended competencies were reviewed. Current federal funding and training opportunities were identified...
April 20, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28511085/development-implementation-and-effects-of-an-integrated-web-based-teaching-model-in-a-nursing-ethics-course
#6
S-Y Chao, Y-C Chang, S C Yang, M J Clark
BACKGROUND: Ethical competence, which is reflected in the ability to detect ethical challenges in clinical situations and engage in deliberate thinking on ethical actions, is one of the core competencies of nursing practice. PURPOSE: The purpose of this study was to develop and implement an interactive situational e-learning system, integrating nursing ethical decisions into a nursing ethics course, and to evaluate the effects of this course on student nurses' ethical decision-making competence...
April 19, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28507369/nature-scope-and-use-of-economic-evaluation-of-healthcare-programmes-with-special-reference-to-pakistan
#7
Muhammad Ashar Malik, Saleem Perwaiz Iqbal, Farina Gul Abrejo
Economic evaluation (EE)/cost effectiveness analysis(CEA) of healthcare programmes is an emerging area, yet the resource base to apprehend EE/CEA is very limited in Pakistan. This paper attempts to fill this gap by providing a basic text in the field of EE with special reference to Pakistan. We used four dimensional criteria (available, relevant, complete and accurate) for reviewing the EE contents in the locally available textbooks and reading material on public health. We find CEA as core competency and skill of medical doctors in undergraduate medical curricula yet we could not find EE contents in the recommended textbooks...
May 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28506527/ancestral-interactions-of-ribosomal-rna-and-ribosomal-proteins
#8
Kathryn A Lanier, Poorna Roy, Dana M Schneider, Loren Dean Williams
We have proposed that the ancient ribosome increased in size during early evolution by addition of small folding-competent RNAs. In this Accretion Model, small RNAs and peptides were subsumed onto subunit surfaces, gradually encasing and freezing previously acquired components. The model predicts that appropriate rRNA fragments have inherited local autonomy of folding and local autonomy of assembly with ribosomal proteins (rProteins), and that the rProtein and rRNA are co-chaperones. To test these predictions, we investigate the rRNA interactions of rProtein uL23 and its tail, uL23(tail), which is a β-hairpin that penetrates deep into the core of the large ribosomal subunit...
May 12, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28505523/trainers-perception-of-the-learning-environment-and-student-competency-a-qualitative-investigation-of-midwifery-and-anesthesia-training-programs-in-ethiopia
#9
Sharon Kibwana, Rachel Haws, Adrienne Kols, Firew Ayalew, Young-Mi Kim, Jos van Roosmalen, Jelle Stekelenburg
BACKGROUND: Ethiopia has successfully expanded training for midwives and anesthetists in public institutions. This study explored the perceptions of trainers (instructors, clinical lab assistants and preceptors) towards the adequacy of students' learning experience and implications for achieving mastery of core competencies. METHODS: In-depth interviews with 96 trainers at 9 public universities and 17 regional health science colleges across Ethiopia were conducted to elicit their opinions about available resources, program curriculum suitability, and competence of graduating students...
May 1, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28504991/tablet-e-logbooks-four-thousand-clinical-cases-and-complications-e-logged-by-14-nondoctor-anesthesia-providers-in-nepal
#10
Shristi Shah, Oliver Ross, Stephen Pickering, Stephen Knoble, Indra Rai
BACKGROUND: To meet the need for essential surgery across rural Nepal, anesthesia at district level is delivered by nondoctor anesthetists. They require support to maintain confidence and competence, and upgraded professional registration to secure their status. To meet these needs, a distance-blended learning course was pioneered and delivered. A core course requirement was to log all clinical cases; these were logged on a new e-logbook. METHODS: Fourteen nondoctor anesthesia providers working in 12 different districts across Nepal were enrolled in the 1-year course...
May 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28504028/essential-competencies-in-global-health-research-for-medical-trainees-a-narrative-review
#11
Mary T White, Caley A Satterfield, Jason T Blackard
INTRODUCTION: Participation in short-term educational experiences in global health (STEGHs) among medical trainees is increasingly accompanied by interest in conducting research while abroad. Because formal training in both global health and research methods is currently under-represented in most medical curricula, trainees are often unfamiliar with the knowledge, attitudes, and skills necessary to design and conduct research successfully. This narrative review identifies essential global health research competencies for medical trainees engaged in STEGHs...
May 14, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28503194/what-are-effective-strategies-for-implementing-trauma-informed-care-in-youth-inpatient-psychiatric-and-residential-treatment-settings-a-realist-systematic-review
#12
REVIEW
Stephanie A Bryson, Emma Gauvin, Ally Jamieson, Melanie Rathgeber, Lorelei Faulkner-Gibson, Sarah Bell, Jana Davidson, Jennifer Russel, Sharlynne Burke
BACKGROUND: Many young people who receive psychiatric care in inpatient or residential settings in North America have experienced various forms of emotional trauma. Moreover, these settings can exacerbate trauma sequelae. Common practices, such as seclusion and restraint, put young people at risk of retraumatization, development of comorbid psychopathology, injury, and even death. In response, psychiatric and residential facilities have embraced trauma-informed care (TIC), an organizational change strategy which aligns service delivery with treatment principles and discrete interventions designed to reduce rates of retraumatization through responsive and non-coercive staff-client interactions...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28498034/assessment-of-resident-physicians-communicator-and-collaborator-competencies-by-interprofessional-clinicians-a-mixed-methods-study
#13
Lyn K Sonnenberg, Lesley Pritchard-Wiart, Carol S Hodgson, YongQiang Yu, Sharla King
Phenomenon: As we move toward competency-based medical education, greater emphasis is being placed on assessing a more comprehensive skill set, including the ability to communicate and collaborate effectively in the workplace. Nonphysician members on interprofessional (IP) teams have valuable perspectives on actual resident performance and are often not adequately engaged in the provision of feedback to residents. Based on the educational theories of collaborative evaluation and social constructivism, this research examined the ability of IP clinicians to provide feedback to residents...
May 12, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28496274/student-self-assessment-and-faculty-assessment-of-performance-in-an-interprofessional-error-disclosure-simulation-training-program
#14
Therese I Poirier, Junvie Pailden, Ray Jhala, Katie Ronald, Miranda Wilhelm, Jingyang Fan
Objectives. To conduct a prospective evaluation for effectiveness of an error disclosure assessment tool and video recordings to enhance student learning and metacognitive skills while assessing the IPEC competencies. Design. The instruments for assessing performance (planning, communication, process, and team dynamics) in interprofessional error disclosure were developed. Student self-assessment of performance before and after viewing the recordings of their encounters were obtained. Faculty used a similar instrument to conduct real-time assessments...
April 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28495309/group-ii-introns-in-wheat-mitochondria-have-degenerate-structural-features-and-varied-splicing-pathways
#15
Matthew Ngu, Karen Massel, Linda Bonen
Mitochondrial introns in flowering plant genes are virtually all classified as members of the group II ribozyme family although certain structural features have degenerated to varying degrees over evolutionary time. We are interested in the impact that unconventional intron architecture might have on splicing biochemistry in vivo and we have focused in particular on intronic domains V and VI, which for self-splicing introns provide a key component of the catalytic core and the bulged branchpoint adenosine, respectively...
May 8, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28495207/targeting-the-hsp90-c-terminal-domain-to-induce-allosteric-inhibition-and-selective-client-downregulation
#16
Kourtney M Goode, Dino Petrov, Renee E Vickman, Scott A Crist, Pete E Pascuzzi, Tim L Ratliff, V Jo Davisson, Tony R Hazbun
BACKGROUND: Inhibition of Hsp90 is desirable due to potential downregulation of oncogenic clients. Early generation inhibitors bind to the N-terminal domain (NTD) but C-terminal domain (CTD) inhibitors are a promising class because they do not induce a heat shock response. Here we present a new structural class of CTD binding molecules with a unique allosteric inhibition mechanism. METHODS: A hit molecule, NSC145366, and structurally similar probes were assessed for inhibition of Hsp90 activities...
May 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28495022/delineating-the-joint-hierarchical-structure-of-clinical-and-personality-disorders-in-an-outpatient-psychiatric-sample
#17
Miriam K Forbes, Roman Kotov, Camilo J Ruggero, David Watson, Mark Zimmerman, Robert F Krueger
BACKGROUND: A large body of research has focused on identifying the optimal number of dimensions - or spectra - to model individual differences in psychopathology. Recently, it has become increasingly clear that ostensibly competing models with varying numbers of spectra can be synthesized in empirically derived hierarchical structures. METHODS AND MATERIALS: We examined the convergence between top-down (bass-ackwards or sequential principal components analysis) and bottom-up (hierarchical agglomerative cluster analysis) statistical methods for elucidating hierarchies to explicate the joint hierarchical structure of clinical and personality disorders...
April 29, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28494954/competing-pathways-and-multiple-folding-nuclei-in-a-large-multidomain-protein-luciferase
#18
Zackary N Scholl, Weitao Yang, Piotr E Marszalek
Proteins obtain their final functional configuration through incremental folding with many intermediate steps in the folding pathway. If known, these intermediate steps could be valuable new targets for designing therapeutics and the sequence of events could elucidate the mechanism of refolding. However, determining these intermediate steps is hardly an easy feat, and has been elusive for most proteins, especially large, multidomain proteins. Here, we effectively map part of the folding pathway for the model large multidomain protein, Luciferase, by combining single-molecule force-spectroscopy experiments and coarse-grained simulation...
May 9, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28493638/chemically-controlled-spatiotemporal-oscillations-of-colloidal-assemblies
#19
Alicia Altemose, Maria A Sánchez-Farrán, Wentao Duan, Steve Schulz, Ali Borhan, Vincent H Crespi, Ayusman Sen
We report an autonomous oscillatory micromotor system in which active colloidal particles form clusters whose size changes periodically. The system consists of an aqueous suspension of silver orthophosphate microparticles under UV illumination, in the presence of varying concentrations of hydrogen peroxide. The colloid particles oscillate between clustering and dispersion. After a cluster oscillation initiates, the oscillatory wave propagates to nearby clusters and eventually all the clusters start oscillating in phase-shifted synchrony...
May 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28490644/background-noise-exerts-diverse-effects-on-the-cortical-encoding-of-foreground-sounds
#20
Brian James Malone, Marc A Heiser, Ralph Eugene Beitel, Christoph E Schreiner
In natural listening conditions, many sounds must be detected and identified in the context of competing sound sources which function as background noise. Traditionally, noise is thought to degrade the cortical representation of sounds by suppressing responses and increasing response variability. However, recent studies of neural network models and brain slices have shown that background synaptic noise can improve the detection of signals. Because acoustic noise affects the synaptic background activity of cortical networks, it may improve the cortical responses to signals...
May 10, 2017: Journal of Neurophysiology
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