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Core competencies

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https://www.readbyqxmd.com/read/28102845/h19-let-7-lin28-reciprocal-negative-regulatory-circuit-promotes-breast-cancer-stem-cell-maintenance
#1
Fei Peng, Ting-Ting Li, Kai-Li Wang, Guo-Qing Xiao, Ju-Hong Wang, Hai-Dong Zhao, Zhi-Jie Kang, Wen-Jun Fan, Li-Li Zhu, Mei Li, Bai Cui, Fei-Meng Zheng, Hong-Jiang Wang, Eric W-F Lam, Bo Wang, Jie Xu, Quentin Liu
Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains elusive. Here we show that breast cancer stem cells (BCSCs) express high levels of H19, and ectopic overexpression of H19 significantly promotes breast cancer cell clonogenicity, migration and mammosphere-forming ability. Conversely, silencing of H19 represses these BCSC properties. In concordance, knockdown of H19 markedly inhibits tumor growth and suppresses tumorigenesis in nude mice...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28099313/what-makes-a-competent-orthopaedist-commentary-on-an-article-by-james-f-kellam-md-on-behalf-of-the-general-orthopaedic-competency-task-force-the-core-competencies-for-general-orthopaedic-surgeons
#2
https://www.readbyqxmd.com/read/28099309/the-core-competencies-for-general-orthopaedic-surgeons
#3
James F Kellam, Douglas Archibald, James W Barber, Eugene P Christian, Richard J D'Ascoli, Richard J Haynes, Suzanne S Hecht, Shepard R Hurwitz, James F Kellam, Alexander C McLaren, Terrance D Peabody, Stephen R Southworth, Robert W Strauss, Veronica M R Wadey
BACKGROUND: With the changing delivery of orthopaedic surgical care, there is a need to define the knowledge and competencies that are expected of an orthopaedist providing general and/or acute orthopaedic care. This article provides a proposal for the knowledge and competencies needed for an orthopaedist to practice general and/or acute care orthopaedic surgery. METHODS: Using the modified Delphi method, the General Orthopaedic Competency Task Force consisting of stakeholders associated with general orthopaedic practice has proposed the core knowledge and competencies that should be maintained by orthopaedists who practice emergency and general orthopaedic surgery...
January 18, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28098959/influence-of-electronic-and-molecular-structure-on-the-fragmentation-dynamic-of-even-electron-carbocationic-triangulenes-and-helicenes-in-the-gas-phase
#4
Jakob Felix Hitzenberger, Agnes Uhl, Jürgen Schatz, Thomas Drewello
Stable, long-lived organic cations are directly transferred by electrospray ionization (ESI) from solution into the gas phase where their collision-induced dissociations (CID) are studied by tandem mass spectrometry. Three related types of triphenyl carbenium ions are investigated, in which the meta positions are either substituted by methoxy groups or tertiary nitrogen bridges, including Tetramethoxyphenylacridinium (TMPA(+) ), dimethoxyquinacridinium (DMQA(+) ) and triazatriangulenium (TATA(+) ) cations. These ions are triangular in shape with increasing degrees of planarity...
January 18, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28097957/if-medical-education-was-a-discipline-she-would-have-five-core-competencies
#5
Constance R Tucker
To date, many medical schools define medical educators by who they teach rather than the quality of their engagement with learners. In addition, evidence suggests that a traditional terminal degree may not satisfy the developmental needs of educators engaged in competency based medical education. Perhaps, medical educators require additional competencies. This personal view introduces five competencies that enliven the way in which medical educators engage in career paths, recruitment, performance assessment, compensation, and professional development...
January 18, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28095811/an-integrated-recovery-oriented-model-irm-for-mental-health-services-evolution-and-challenges
#6
Barry G Frost, Srinivasan Tirupati, Suzanne Johnston, Megan Turrell, Terry J Lewin, Ketrina A Sly, Agatha M Conrad
BACKGROUND: Over past decades, improvements in longer-term clinical and personal outcomes for individuals experiencing serious mental illness (SMI) have been moderate, although recovery has clearly been shown to be possible. Recovery experiences are inherently personal, and recovery can be complex and non-linear; however, there are a broad range of potential recovery contexts and contributors, both non-professional and professional. Ongoing refinement of recovery-oriented models for mental health (MH) services needs to be fostered...
January 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28094994/ag-sn-bimetallic-catalyst-with-a-core-shell-structure-for-co2-reduction
#7
Wesley W Luc, Charles Collins, Siwen Wang, Hongliang Xin, Kai He, Yijin Kang, Feng Jiao
Converting greenhouse gas carbon dioxide (CO2) to value-added chemicals is an appealing approach to tackle CO2 emission challenges. The chemical transformation of CO2 requires suitable catalysts that can lower the activation energy barrier, thus minimizing the energy penalty associated with the CO2 reduction reaction. First-row transition metals are potential candidates as catalysts for electrochemical CO2 reduction; however, their high oxygen affinity makes them easy to be oxidized, which could, in turn, strongly affect the catalytic properties of metal-based catalysts...
January 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28093428/exploring-health-literacy-competencies-towards-patient-education-programme-for-chinese-speaking-healthcare-professionals-a-delphi-study
#8
Li-Chun Chang, Yu-Chi Chen, Fei Ling Wu, Li-Ling Liao
OBJECTIVES: To achieve consensus on a set of competencies in health literacy practice based on a literature review and expert consultation. SETTING: Hospitals and community health centres in Taiwan. METHOD: A 2-stage modified Delphi study involving a literature review was conducted, followed by qualitative interviews and 3 rounds of email-based data collection over a 3-month period in 2011. PARTICIPANTS: 15 Chinese healthcare practitioners with more than 6 months' experience in patient education were interviewed to collect data on health literacy practice...
January 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28088985/lymphocyte-generation-and-population-homeostasis-throughout-life
#9
REVIEW
Rolando E Yanes, Claire E Gustafson, Cornelia M Weyand, Jörg J Goronzy
Immune aging is a multi-faceted process that manifests as reduced competence to fight infections and malignant cells, as well as diminished tissue repair, unprovoked inflammation, and increased autoreactivity. The aging adaptive immune system, with its high complexity in functional cell subpopulations and diversity of B- and T-cell receptors, has to cope with the challenge of maintaining homeostasis while responding to exogenous stimuli and compensating for reduced generative capacity. With thymic involution, naïve T cells begin to function as quasi-stem cells and maintain the compartment through peripheral homeostatic proliferation that shapes the T-cell repertoire through peripheral selection and the activation of differentiation pathways...
January 2017: Seminars in Hematology
https://www.readbyqxmd.com/read/28079725/new-medicine-for-the-u-s-health-care-system-training-physicians-for-structural-interventions
#10
Helena Hansen, Jonathan M Metzl
Structural competency provides a language and theoretical framework to promote institutional-level interventions by clinical practitioners working with community organizations, non-health-sector institutions, and policy makers. The special collection of articles on structural competency in this issue of Academic Medicine addresses the need to move from theory to an appraisal of core educational interventions that operationalize the goals of and foster structural competency. In this Commentary, the authors review the role of clinical practitioners in enhancing population-level health outcomes through collaborations with professionals in fields outside medicine, including the social sciences and law...
January 10, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28077912/emptyheaded-a-relational-engine-for-graph-processing
#11
Christopher R Aberger, Susan Tu, Kunle Olukotun, Christopher Ré
There are two types of high-performance graph processing engines: low- and high-level engines. Low-level engines (Galois, PowerGraph, Snap) provide optimized data structures and computation models but require users to write low-level imperative code, hence ensuring that efficiency is the burden of the user. In high-level engines, users write in query languages like datalog (SociaLite) or SQL (Grail). High-level engines are easier to use but are orders of magnitude slower than the low-level graph engines. We present EmptyHeaded, a high-level engine that supports a rich datalog-like query language and achieves performance comparable to that of low-level engines...
June 2016: Proceedings
https://www.readbyqxmd.com/read/28077739/the-emergence-of-undergraduate-majors-in-global-health-systematic-review-of-programs-and-recommendations-for-future-directions
#12
Paul K Drain, Charles Mock, David Toole, Anne Rosenwald, Megan Jehn, Thomas Csordas, Laura Ferguson, Caryl Waggett, Chinekwu Obidoa, Judith N Wasserheit
Global health education has been expanding rapidly and several universities have created an undergraduate major degree (bachelor's degree) in global heath or global health studies. Because there are currently no national guidelines for undergraduate degrees in global health, each of these programs was developed along individual lines. To guide the development of future global health majors, we conducted a systematic review of undergraduate majors in global health. We identified eight programs and invited program directors or representatives to a symposium at the Consortium of Universities for Global Health 2016 conference to review their existing undergraduate major in global health and to discuss lessons learned and recommendations for other colleges and universities seeking to develop undergraduate degrees in global health...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28076588/-essential-competencies-in-training-in-obstetrics
#13
Sebastião Junior Henrique Duarte, Richardson Miranda Machado
Objective: Analyze international reports related to training in obstetrics and present guidelines to help leading educational institutions to develop curriculum guidelines for the teaching of obstetrics and advanced nursing practice in this specialty. Methods: A narrative review was conducted of documents from the World Health Organization and the International Confederation of Midwives. The search used the descriptors midwifery and education. All official reports that guide midwife education policies, published from 2009 to 2015 in English and Spanish, and available online, were included...
November 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28074621/total-synthesis-of-tetrodotoxin-and-11-norttx-6-r-ol
#14
Tomoaki Maehara, Keisuke Motoyama, Tatsuya Toma, Satoshi Yokoshima, Tohru Fukuyama
The enantioselective total synthesis of (-)-tetrodotoxin [(-)-TTX] and 4,9-anhydrotetrodotoxin, which are selective blockers of voltage-gated sodium channels, was accomplished from the commercially available p-benzoquinone. This synthesis was based on efficient stereocontrol of the six contiguous stereogenic centers on the core cyclohexane ring through Ogasawara's method, [3,3]-sigmatropic rearrangement of an allylic cyanate, and intramolecular 1,3-dipolar cycloaddition of a nitrile oxide. Our synthetic route was applied to the synthesis of the tetrodotoxin congeners 11-norTTX-6(R)-ol and 4,9-anhydro-11-norTTX-6(R)-ol through late-stage modification of the common intermediate...
January 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28072647/tools-for-practical-psychotherapy-a-transtheoretical-collection-or-interventions-which-have-at-least-worked-for-us
#15
Joel Yager, Robert E Feinstein
BACKGROUND AND OBJECTIVES: Regardless of their historical and theoretical roots, strategies, tactics, and techniques used in everyday psychotherapy across diverse theoretical schools contain common factors and methods from other specific psychotherapeutic modalities that contribute substantially to psychotherapy outcomes. Common factors include alliance, empathy, goal consensus/collaboration, positive regard/affirmation, and congruence/genuineness, among others. All therapies also recognize that factors specific to therapists impact treatment...
January 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28071914/synthesis-and-nmr-analysis-of-a-conformationally-controlled-%C3%AE-turn-mimetic-torsion-balance
#16
Alyssa B Lypson, Craig S Wilcox
The molecular torsion balance concept was applied to a new conformationally controlled scaffold and synthesized to accurately evaluate pairwise amino acid interactions in an antiparallel β-sheet motif. The scaffold's core design combines (ortho-tolyl)amide and o,o,o'-trisubstituted biphenyl structural units to provide a geometry better-suited for intramolecular hydrogen bonding. Like the dibenzodiazocine hinge of the traditional torsion balance, the (ortho-tolyl)amide unit offers restricted rotation around an N-aryl bond...
January 10, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28068538/utilization-of-peers-in-services-for-youth-with-emotional-and-behavioral-challenges-a-scoping-review
#17
Geetha Gopalan, Sang Jung Lee, Ryan Harris, Mary C Acri, Michelle R Munson
This scoping review synthesizes published and unpublished information on Youth Peer Support Services (YPSS), where young adults with current or prior mental health challenges provide support services to other youth and young adults currently struggling with similar difficulties. Existing published and unpublished "grey" literature were reviewed, yielding 30 programs included for data extraction and qualitative syntheses using a descriptive analytic framework. Findings identify variations in service delivery structures, program goals, host service systems, peer roles, core competencies, training and supervision needs, outcomes for youth and young adult consumers, as well as organizational readiness needs to integrate YPSS...
January 6, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28067040/large-pore-3-d-cubic-mesoporous-kit-6-hybrid-bearing-hard-soft-donor-combined-ligand-for-enhancing-u-vi-capture-an-experimental-and-theoretical-investigation
#18
Li-Yong Yuan, Lin Zhu, Chengliang Xiao, Qun-Yan Wu, Nan Zhang, Ji-Pan Yu, Zhifang Chai, Wei-Qun Shi
The preorganized tetradentate phenanthrolineamide (DAPhen) ligand with hard-soft donors combined in the same molecule has been found to possess high extraction ability towards actinides over lanthanides from acidic aqueous solution in our previous work. Herein, we grafted phenanthrolineamide groups onto a large pore three-dimensional (3-D) cubic silica support by the reaction of DAPhen siloxane with KIT-6 substrate to prepare a novel uranium-selective sorbent, KIT-6-DAPhen. The as-synthesized sorbent was well characterized by SEM, HRTEM, N2 adsorption/desorption, XRD, FT-IR, 13C CP/MAS NMR, and TGA techniques, which confirmed the consummation of the functionalization...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28066950/pd-peppsi-ipentcl-a-useful-catalyst-for-the-coupling-of-2-aminopyridine-derivatives
#19
Michael G Organ, Abir Khadra, Stanislas Mayer
Pd-PEPPSI-IPentCl precatalyst has been demonstrated to be highly effective at the coupling of hetero(aryl)chlorides to free 2-aminopyridine substrates to produce N-(hetero)aryl-2-aminopyridine derivatives. The catalyst has proven competent in a number of other difficult cross-coupling reactions owing to the combination of the 3-penyl-substituted N-aryl groups and the chlorines on the backbone of the NHC core. This same reactivity here allows couplings to take place under very mild conditions (e.g., NaBHT or carbonate base) such that sensitive functional groups including esters, ketones, and nitriles are tolerated...
January 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28066545/predicting-signatures-of-anisotropic-resonance-energy-transfer-in-dye-functionalized-nanoparticles
#20
Gabriel Gil, Stefano Corni, Alain Delgado, Andrea Bertoni, Guido Goldoni
Resonance energy transfer (RET) is an inherently anisotropic process. Even the simplest, well-known Förster theory, based on the transition dipole-dipole coupling, implicitly incorporates the anisotropic character of RET. In this theoretical work, we study possible signatures of the fundamental anisotropic character of RET in hybrid nanomaterials composed of a semiconductor nanoparticle (NP) decorated with molecular dyes. In particular, by means of a realistic kinetic model, we show that the analysis of the dye photoluminescence difference for orthogonal input polarizations reveals the anisotropic character of the dye-NP RET which arises from the intrinsic anisotropy of the NP lattice...
November 13, 2016: RSC Advances
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