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Aspergers Syndrome

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https://www.readbyqxmd.com/read/29881339/new-protocol-for-quantitative-analysis-of-brain-cortex-electroencephalographic-activity-in-patients-with-psychiatric-disorders
#1
Grzegorz M Wojcik, Jolanta Masiak, Andrzej Kawiak, Piotr Schneider, Lukasz Kwasniewicz, Nikodem Polak, Anna Gajos-Balinska
The interview is still the main and most important tool in psychiatrist's work. The neuroimaging methods such as CT or MRI are widely used in other fields of medicine, for instance neurology. However, psychiatry lacks effective quantitative methods to support of diagnosis. A novel neuroinformatic approach to help clinical patients by means of electroencephalographic technology in order to build foundations for finding neurophysiological biomarkers of psychiatric disorders is proposed. A cohort of 30 right-handed patients (21 males, 9 females) with psychiatric disorders (mainly with panic and anxiety disorder, Asperger syndrome as well as with phobic anxiety disorders, schizophrenia, bipolar affective disorder, obsessive-compulsive disorder, nonorganic hypersomnia, and moderate depressive episode) were examined using the dense array EEG amplifier in the P300 experiment...
2018: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/29875476/a-comparative-study-of-the-genetic-components-of-three-subcategories-of-autism-spectrum-disorder
#2
Jinchen Li, Shanshan Hu, Kun Zhang, Leisheng Shi, Yi Zhang, Tingting Zhao, Lin Wang, Xin He, Kun Xia, Chunyu Liu, Zhongsheng Sun
The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) controversially combined previously distinct subcategories of autism spectrum disorder (ASD) into a single diagnostic category. However, genetic convergences and divergences between different ASD subcategories are unclear. By retrieving 1725 exonic de novo mutations (DNMs) from 1628 subjects with autistic disorder (AD), 1873 from 1564 subjects with pervasive developmental disorder not otherwise specified (PDD-NOS), 276 from 247 subjects with Asperger's syndrome (AS), and 2077 from 2299 controls, we found that rates of putative functional DNMs (loss-of-function, predicted deleterious missense, and frameshift) in all three subcategories were significantly higher than those in control...
June 6, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29763648/autism-spectrum-disorder-classification-diagnosis-and-therapy
#3
REVIEW
Samata R Sharma, Xenia Gonda, Frank I Tarazi
Autism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders including autism, Asperger's syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS). The new diagnostic criteria of ASD focuses on two core domains: social communication impairment and restricted interests/repetitive behaviors. The prevalence of ASD has been steadily increasing over the past two decades, with current estimates reaching up to 1 in 36 children. Hereditary factors, parental history of psychiatric disorders, pre-term births, and fetal exposure to psychotropic drugs or insecticides have all been linked to higher risk of ASD...
May 12, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29713442/hans-asperger-national-socialism-and-race-hygiene-in-nazi-era-vienna
#4
Herwig Czech
Background: Hans Asperger (1906-1980) first designated a group of children with distinct psychological characteristics as 'autistic psychopaths' in 1938, several years before Leo Kanner's famous 1943 paper on autism. In 1944, Asperger published a comprehensive study on the topic (submitted to Vienna University in 1942 as his postdoctoral thesis), which would only find international acknowledgement in the 1980s. From then on, the eponym 'Asperger's syndrome' increasingly gained currency in recognition of his outstanding contribution to the conceptualization of the condition...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29695940/camus-s-l-%C3%A3-tranger-and-the-first-description-of-a-man-with-asperger-s-syndrome
#5
Sam Shuster
The continued discussion about the meaning of Camus's famous novel, L'étranger , provoked a re-reading, and this, in turn, led to its clinical analysis and further investigation. The book rests entirely on the thoughts, words and actions of its central character, Meursault, and these were found to show impairment of social relationships, communication and interaction, with other traits diagnostic of the Asperger's subgroup of the autism spectrum disorder. It was then found that Camus had based Meursault on his close friend Galindo, and a search was therefore made for evidence of Galindo's character; this revealed him to be an intelligent but odd person, who exhibited the characteristic impairment of social and personal behavior of Asperger's syndrome...
2018: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29694960/kynurenine-pathway-in-autism-spectrum-disorders-in-children
#6
Vesna Bryn, Robert Verkerk, Ola H Skjeldal, Ola Didrik Saugstad, Heidi Ormstad
BACKGROUND: There is increasing evidence that altered immune responses play a role in the pathogenesis of autism spectrum disorders (ASD), together with dysfunction of the serotonergic and glutamatergic systems. Since the kynurenine (KYN) pathway that degrades tryptophan (TRP) is activated in various neuroinflammatory states, we aimed to determine whether this pathway is activated in ASD. METHODS: Sixty-five pediatric ASD patients (including 52 boys) were enrolled from an epidemiological survey covering 2 counties in Norway; 30 (46...
April 25, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29666039/comment-on-olanzapine-induced-priapism-in-a-child-with-asperger-s-syndrome
#7
Mete Özkıdık, Anar İbrahimov
No abstract text is available yet for this article.
April 15, 2018: Balkan Medical Journal
https://www.readbyqxmd.com/read/29628271/functional-network-abnormalities-consistent-with-behavioral-profile-in-autism-spectrum-disorder
#8
René Besseling, Rolf Lamerichs, Britt Michels, Stephan Heunis, Anton de Louw, Anton Tijhuis, Jan Bergmans, Bert Aldenkamp
Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which the severity of symptoms varies over subjects. The iCAPs model (innovation-driven co-activation patterns) is a recently developed spatio-temporal model to describe fMRI data. In this study, the iCAPs model was employed to find functional imaging biomarkers for ASD in resting-state fMRI data. MRI data from 125 ASD patients and 243 healthy controls was selected from the online ABIDE data repository. Following standard fMRI preprocessing steps, the iCAP patterns were fitted to the data to obtain network time series...
May 30, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29546821/-asperger-syndrome-and-or-clinical-high-risk-of-psychosis-a-differential-diagnostic-challenge
#9
Stefanie J Schmidt, Ayla Behar, Frauke Schultze-Lutter
Asperger Syndrome and/or Clinical High Risk of Psychosis? A Differential Diagnostic Challenge This case-study deals with the often difficult differential diagnosis of Asperger syndrome and a clinical high risk state of psychosis, in particular as indicated by attenuated psychotic symptoms, as well as with its therapeutic implications. The presented case is a 10-year old girl, who has not been diagnosed with an autism spectrum disorder before being referred to a specialized center for early detection of psychosis due to possible hallucinatory experiences and delusional ideas...
March 2018: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29516452/-perisylvian-magnetoencephalografic-impairments-in-patients-with-autism-spectrum-disorders
#10
M Palau-Baduell, B Salvado-Salvado, M A Idiazabal-Alecha, A Fernandez-Teruel, T Ortiz
INTRODUCTION: The perisylvian areas, located around the Sylvian fissure, are constituted by frontal, temporal and parietal brain regions. These are connected forming specialized neural networks and play a primary role in the development of linguistic skills and social cognition. These areas are a possible neuronal substrate of cognitive and behavioral impairments in patients with autism spectrum disorders (ASD). AIM: To locate and quantify epileptiform activity sources through magnetoencephalography in frontal perisylvian areas in children with idiopathic ASD...
March 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29477010/impaired-detection-and-differentiation-of-briefly-presented-facial-emotions-in-adults-with-high-functioning-autism-and-asperger-syndrome
#11
R Frank, L Schulze, R Hellweg, S Koehne, S Roepke
Although deficits in the recognition of emotional facial expressions are considered a hallmark of autism spectrum disorder (ASD), characterization of abnormalities in the differentiation of emotional expressions (e.g., sad vs. angry) has been rather inconsistent, especially in adults without intellectual impairments who may compensate for their deficits. In addition, previous research neglected the ability to detect emotional expressions (e.g., angry vs. neutral). The present study used a backward masking paradigm to investigate, a) the detection of emotional expressions, and b) the differentiation of emotional expressions in adults diagnosed with high functioning autism or Asperger syndrome (n = 23) compared to neurotypical controls (n = 25)...
May 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29427542/school-dysfunction-in-youth-with-autistic-spectrum-disorder-in-taiwan-the-effect-of-subtype-and-adhd
#12
Huey-Ling Chiang, Wei-Chih Kao, Mei-Chun Chou, Wen-June Chou, Yen-Nan Chiu, Yu-Yu Wu, Susan Shur-Fen Gau
School dysfunction is observed in youths with autism spectrum disorder (ASD), but the factors moderating their school dysfunction have not been well explored. This study investigated school functions in youths with ASD in Taiwan, stratified by personal characteristics including demographics, ASD subtypes, intelligence profiles, and the presence of attention-deficit hyperactivity disorder (ADHD). We recruited 160 youths (aged 6-18 years, 87.5% boys) with a clinical diagnosis of ASD and 160 age and gender-matched typically developing (TD) youths...
February 10, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29423607/brief-report-social-functioning-predicts-externalizing-problem-behaviors-in-autism-spectrum-disorder
#13
N Shea, E Payne, N Russo
Individuals with ASD often display externalizing behaviors, which have been associated with lower quality of life in adulthood. Social difficulties have been hypothesized to underlie externalizing problems among individuals with ASD (Klin and Volkmar in Asperger Syndrome, 340-366, 2000), but this has never been tested empirically. We examined whether socialization abilities predicted externalizing problems assessed by parent report in a group of 29 individuals with ASD (age range 7-16 years) and 29 TD individuals matched for IQ, age, and gender...
February 8, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29417447/maternal-and-family-processes-in-different-subgroups-of-youth-with-autism-spectrum-disorder
#14
Jane Pei-Chen Chang, Meng-Chuan Lai, Miao-Chun Chou, Chi-Yung Shang, Yen-Nan Chiu, Wen-Che Tsai, Yu-Yu Wu, Susan Shur-Fen Gau
We compared the maternal reports on mothering and family processes between 160 youth with autism spectrum disorder (ASD) and 160 age and gender-matched typically developing (TD) youth stratified by personal characteristics from Taiwan. The ASD groups consisted of 51 'typical autism' (TA), 52 'high-functioning autism' (HFA), and 57 'Asperger syndrome (AS).' Maternal reports showed that youth with ASD obtained less affection and more protection from the mother, and had less active mother-child interactions and more behavioral problems at home...
February 8, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29400401/emotional-preferences-and-goals-and-emotion-dysregulation-in-children-with-asperger-s-syndrome-and-typically-developing-children
#15
Belén López-Pérez, Tamara Ambrona, Michaela Gummerum
OBJECTIVES: Emotion goals lie at the heart of emotion regulation, as people have to first decide what emotions they want to feel before engaging in emotion regulation. Given that children with Asperger's syndrome (AS) are characterized by exhibiting difficulties in emotion regulation, studying whether they display similar or different emotion goals compared to typically developing (TD) children may provide insightful information. METHODS: Thirty AS and 30 TD children (10-12 years) reported about their general (i...
February 5, 2018: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29244813/a-different-view-on-the-necker-cube-differences-in-multistable-perception-dynamics-between-asperger-and-non-asperger-observers
#16
Jürgen Kornmeier, Rike Wörner, Andreas Riedel, Ludger Tebartz van Elst
BACKGROUND: During observation of the Necker cube perception becomes unstable and alternates repeatedly between a from-above-perspective ("fap") and a from-below-perspective ("fbp") interpretation. Both interpretations are physically equally plausible, however, observers usually show an a priori top-down bias in favor of the fap interpretation. Patients with Autism spectrum disorder are known to show an altered pattern of perception with a focus on sensory details...
2017: PloS One
https://www.readbyqxmd.com/read/29167722/behavioral-cognitive-and-neural-markers-of-asperger-syndrome
#17
REVIEW
Farnaz Faridi, Reza Khosrowabadi
Asperger syndrome (AS) is a subtype of Autism Spectrum Disorder (ASD) characterized by major problems in social and nonverbal communication, together with limited and repetitive forms of behavior and interests. The linguistic and cognitive development in AS is preserved which help us to differentiate it from other subtypes of ASD. However, significant effects of AS on cognitive abilities and brain functions still need to be researched. Although a clear cut pathology for Asperger has not been identified yet, recent studies have largely focused on brain imaging techniques to investigate AS...
September 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/29157514/a-psycho-legal-perspective-on-sexual-offending-in-individuals-with-autism-spectrum-disorder
#18
REVIEW
A Creaby-Attwood, C S Allely
It is important to consider whether there are innate vulnerabilities that increase the risk of an individual with an autistic spectrum disorder (ASD), predominantly those defendants with a diagnosis of Asperger's Syndrome, being charged and convicted of a sexual offence. The significance of such can be readily seen in recent English case law, with judgments on appeal finding convictions unsafe where there have been a number of failings in the Judge's summing up. In this article, we will consider the gravity of Judges omitting to highlight a defendant's diagnosis of autism spectrum disorder and the necessity of detailed explanations to jury members regarding the condition and its effect upon thoughts and behaviour...
November 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29100626/heritable-variation-with-little-or-no-maternal-effect-accounts-for-recurrence-risk-to-autism-spectrum-disorder-in-sweden
#19
Benjamin Hon Kei Yip, Dan Bai, Behrang Mahjani, Lambertus Klei, Yudi Pawitan, Christina M Hultman, Dorothy E Grice, Kathryn Roeder, Joseph D Buxbaum, Bernie Devlin, Abraham Reichenberg, Sven Sandin
BACKGROUND: Autism spectrum disorder (ASD) has both genetic and environmental origins, including potentially maternal effects. Maternal effects describe the association of one or more maternal phenotypes with liability to ASD in progeny that are independent of maternally transmitted risk alleles. While maternal effects could play an important role, consistent with association to maternal traits such as immune status, no study has estimated maternal, additive genetic, and environmental effects in ASD...
April 1, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29036188/family-functioning-parenting-stress-and-quality-of-life-in-mothers-and-fathers-of-polish-children-with-high-functioning-autism-or-asperger-syndrome
#20
Ewa Pisula, Anna Porębowicz-Dörsmann
The aim of the study was to investigate the perception of the family functioning in parents of children with autism spectrum disorders (ASD) with normal-range intelligence and the relationships between family functioning, parenting stress and quality of life. Dyads of parents of children with ASD without intellectual disability and parents of typically developing children (controls) completed a set of self-report questionnaires. Parents of children with ASD reported lower functioning of the family as a whole and their own functioning as family members; they exhibited higher levels of parenting stress and lower quality of life...
2017: PloS One
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