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https://www.readbyqxmd.com/read/28728515/the-prevalence-of-constipation-at-admission-and-after-one-week-of-palliative-care-a-multicenter-study
#1
Sebastiano Mercadante, Francesco Masedu, Marco Maltoni, Daniela De Giovanni, Luigi Montanari, Cristina Pittureri, Raffaella Bertè, Laura Ursini, Franco Marinangeli, Federica Aielli
AIM: To assess the prevalence and intensity of constipation in advanced-cancer patients referred to palliative care, and to assess changes after one week of specialist palliative care. METHODS: Prospective multicenter study in advanced patients for a period of one year. At admission (T0), age, gender, primary tumor, concomitant diseases, Karnofsky status, Palliative prognostic score (PaP) Edmonton Symptom Assessment scale (ESAS), MDAS (Memorial Delirium Assessment Scale), and bowel function index (BFI) were collected...
July 20, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28705121/greenlandic-patients-with-colorectal-cancer-symptomatology-primary-investigations-and-differences-in-diagnostic-intervals-between-nuuk-and-the-rest-of-the-country
#2
Johan Tolstrup, Rasmus Chemnitz Madsen, Maria Vandborg Sneftrup, Birgit Niclasen
BACKGROUND: Colorectal cancer (CRC) is a potentially fatal disease, and expedited referral and treatment is needed to ensure early detection. OBJECTIVE: We aimed to assess the symptomatology of Greenlandic patients with CRC and the primary investigations initiated before referral to Dronning Ingrids Hospital in Nuuk for further diagnostic workup. Primary care interval (first consultation until referral), hospital interval (referral until diagnosis) and diagnostic interval (first consultation until diagnosis) were calculated and compared between patients living in Nuuk and in other places in Greenland ("the Coast")...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28690768/endoscopic-recommendations-for-colorectal-cancer-screening-and-surveillance-in-patients-with-inflammatory-bowel-disease-review-of-general-recommendations
#3
REVIEW
Jose María Huguet, Patricia Suárez, Luis Ferrer-Barceló, Lucía Ruiz, Ana Monzó, Ana Belén Durá, Javier Sempere
Screening for colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) is recommended by all scientific societies. However, there are differences in the recommendations they make regarding screening and surveillance. We address a series of questions that come up in the daily clinical practice of a physician. The first two questions that are raised are: (1) Who should be offered screening for CRC? and (2) When should the first colonoscopy be performed? The next step is to decide who should undergo endoscopic surveillance and at what intervals they should be performed...
June 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28681075/cost-analysis-of-colorectal-cancer-screening-with-ct-colonography-in-italy
#4
Paola Mantellini, Giuseppe Lippi, Lapo Sali, Grazia Grazzini, Silvia Delsanto, Beatrice Mallardi, Massimo Falchini, Guido Castiglione, Francesca Maria Carozzi, Mario Mascalchi, Stefano Milani, Leonardo Ventura, Marco Zappa
OBJECTIVE: Unit costs of screening CT colonography (CTC) can be useful for cost-effectiveness analyses and for health care decision-making. We evaluated the unit costs of CTC as a primary screening test for colorectal cancer in the setting of a randomized trial in Italy. METHODS: Data were collected within the randomized SAVE trial. Subjects were invited to screening CTC by mail and requested to have a pre-examination consultation. CTCs were performed with 64- and 128-slice CT scanners after reduced or full bowel preparation...
July 5, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28676254/patient-navigation-for-colonoscopy-completion-results-of-an-rct
#5
Amy DeGroff, Paul C Schroy, Kerry Grace Morrissey, Beth Slotman, Elizabeth A Rohan, James Bethel, Jennifer Murillo, Weijia Ren, Shelley Niwa, Steven Leadbetter, Djenaba Joseph
INTRODUCTION: Colorectal cancer is a leading cause of cancer-related death in the U.S. Although screening reduces colorectal cancer incidence and mortality, screening rates among U.S. adults remain less than optimal, especially among disadvantaged populations. This study examined the efficacy of patient navigation to increase colonoscopy screening. STUDY DESIGN: RCT. SETTING/PARTICIPANTS: A total of 843 low-income adults, primarily Hispanic and non-Hispanic blacks, aged 50-75 years referred for colonoscopy at Boston Medical Center were randomized into the intervention (n=429) or control (n=427) groups...
July 1, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28674967/adverse-events-during-ct-colonography-for-screening-diagnosis-and-preoperative-staging-of-colorectal-cancer-a-japanese-national-survey
#6
Koichi Nagata, Ken Takabayashi, Takaaki Yasuda, Michiaki Hirayama, Shungo Endo, Ryoichi Nozaki, Takenobu Shimada, Hidenori Kanazawa, Masanori Fujiwara, Norihito Shimizu, Tatema Iwatsuki, Teruaki Iwano, Hiroshi Saito
OBJECTIVES: To retrospectively evaluate the frequencies and magnitudes of adverse events associated with computed tomographic colonography (CTC) for screening, diagnosis and preoperative staging of colorectal cancer. METHODS: A Japanese national survey on CTC was administered by use of an online survey tool in the form of a questionnaire. The questions covered mortality, colorectal perforation, vasovagal reaction, total number of examinations, and examination procedures...
July 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28654132/henoch-sch%C3%A3-nlein-purpura-a-literature-review
#7
Liv Eline Hetland, Kjærsti Sørensen Susrud, Kim Hein Lindahl, Anette Bygum
Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein purpura. The clinical manifestations are thought to arise from IgA depositions in blood vessel walls in the affected organs, mostly skin, gastrointestinal tract, joints and kidneys. Corticosteroids may be effective in rapid resolution of renal manifestations and treating joint and abdominal pain, but they are not proven effective for treating organ manifestations and complications, such as glomerulonephritis, bowel infarction or intussusception...
June 27, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28649593/colonic-microbiota-encroachment-correlates-with-dysglycemia-in-humans
#8
Benoit Chassaing, Shreya M Raja, James D Lewis, Shanthi Srinivasan, Andrew T Gewirtz
BACKGROUND AND AIMS: Mucoid structures that coat the epithelium play an essential role in keeping the intestinal microbiota at a safe distance from host cells. Encroachment of bacteria into the normally almost-sterile inner mucus layer has been observed in inflammatory bowel disease and in mouse models of colitis. Moreover, such microbiota encroachment has also been observed in mouse models of metabolic syndrome, which are associated low-grade intestinal inflammation. Hence, we investigated if microbiota encroachment might correlate with indices of metabolic syndrome in humans...
September 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28626068/colorectal-cancer-screening-how-health-gains-and-cost-effectiveness-vary-by-ethnic-group-the-impact-on-health-inequalities-and-the-optimal-age-range-to-screen
#9
Melissa McLeod, Giorgi Kvizhinadze, Matt Boyd, Jan Barendregt, Diana Sarfati, Nick Wilson, Tony Blakely
Background Screening programmes consistently underserve indigenous populations despite a higher overall burden of cancer. In this study we explore the likely health gains and cost-effectiveness of a national colorectal cancer (CRC) screening programme for the indigenous Māori population of New Zealand (NZ). Methods A Markov model estimated: health benefits (QALYs), costs and cost-effectiveness of biennial immunochemical faecal occult blood testing (FOBTi) of 50-74 year olds, from 2011. Input parameters came from: literature reviews, the NZ Bowel Screening Programme Pilot, and NZ linked health datasets...
June 16, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28625419/recommendation-of-colorectal-cancer-testing-among-primary-care-patients-younger-than-50-with-elevated-risk
#10
Celette Sugg Skinner, Chul Ahn, Ethan A Halm, Wendy Pechero Bishop, Katharine McCallister, Joanne M Sanders, David Farrell, Noel Santini, Amit G Singal
In the era of precision medicine, efforts are needed to identify and tailor screening recommendations among elevated-risk patients. Individuals younger than 50years are an important target population, as they comprise 15% of colorectal (CRC) cases and often present with more advanced disease than their 50+ counterparts. In this large study, 2470 patients ages 25-49 used a tablet-based program that assessed risks, matched risks with screening guidelines, and generated tailored printed guideline-concordant recommendations for patients and their providers...
June 15, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28621643/the-clinical-effectiveness-of-different-surveillance-strategies-to-prevent-colorectal-cancer-in-people-with-intermediate-grade-colorectal-adenomas-a-retrospective-cohort-analysis-and-psychological-and-economic-evaluations
#11
Wendy Atkin, Amy Brenner, Jessica Martin, Katherine Wooldrage, Urvi Shah, Fiona Lucas, Paul Greliak, Kevin Pack, Ines Kralj-Hans, Ann Thomson, Sajith Perera, Jill Wood, Anne Miles, Jane Wardle, Benjamin Kearns, Paul Tappenden, Jonathan Myles, Andrew Veitch, Stephen W Duffy
BACKGROUND: The UK guideline recommends 3-yearly surveillance for patients with intermediate-risk (IR) adenomas. No study has examined whether or not this group has heterogeneity in surveillance needs. OBJECTIVES: To examine the effect of surveillance on colorectal cancer (CRC) incidence; assess heterogeneity in risk; and identify the optimum frequency of surveillance, the psychological impact of surveillance, and the cost-effectiveness of alternative follow-up strategies...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28617757/looking-into-enteric-virome-in-patients-with-ibd-defining-guilty-or-innocence
#12
Susana Lopes, Patricia Andrade, Silvia Conde, Rodrigo Liberal, Cláudia C Dias, Salomão Fernandes, Jorge Pinheiro, Joana S Simões, Fátima Carneiro, Fernando Magro, Guilherme Macedo
BACKGROUND: Although there is some evidence suggesting that certain viruses may be involved in the onset of inflammatory bowel disease (IBD), data regarding viral prevalence and viral load in blood and mucosa of patients with IBD are scarce. The main aim of this study is to evaluate the prevalence and viral load of common Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpes virus 6 in blood and mucosa of adult patients with endoscopic active IBD. METHODS: From January to December 2014, ulcerative colitis and Crohn's disease patients with active endoscopic disease were consecutively enrolled...
August 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28614895/endocuff-assisted-vs-standard-colonoscopy-in-the-fecal-occult-blood-test-based-uk-bowel-cancer-screening-programme-e-cap-study-a-randomized-trial
#13
Rupam Bhattacharyya, Fergus Chedgy, Kesavan Kandiah, Carole Fogg, Bernard Higgins, Ben Haysom-Newport, Lisa Gadeke, Fergus Thursby-Pelham, Richard Ellis, Patrick Goggin, Gaius Longcroft-Wheaton, Pradeep Bhandari
Background and study aims Up to 25 % colorectal adenomas are missed during colonoscopy. The aim of this study was to investigate whether the endocuff could improve polyp detection in an organized bowel cancer screening program (BCSP). Patients and methods This parallel group, single-blinded, randomized controlled trial included patients with positive fecal occult blood test (FOBT) who were attending for BCSP colonoscopy. The primary outcome was the number of polyps per patient. Secondary outcomes included the number of adenomas per patient, adenoma and polyp detection rates, and withdrawal times...
June 14, 2017: Endoscopy
https://www.readbyqxmd.com/read/28600231/the-two-week-wait-referral-pathway-is-not-associated-with-improved-survival-for-patients-with-colorectal-cancer
#14
Muhammad Imran Aslam, Sanjay Chaudhri, Baljit Singh, John Stuart Jameson
AIM: To improve survival rates in patients diagnosed with cancer in the UK, a two-week wait (2ww) referral to first appointment target and a 62 day referral to treatment target were introduced in 2004. This study analyses survival rates for patients diagnosed with colorectal cancer (CRC) by mode of referral and referral to treatment time. METHOD: A prospectively maintained database of CRC outcomes at the University Hospitals of Leicester NHS Trust was analysed. Data for patients diagnosed with CRC was analysed for survival...
June 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28591070/emerging-gastrointestinal-and-liver-diseases-in-asia-pacific-implications-to-health-care-in-the-region-world-gastroenterology-organization-asian-pacific-association-of-gastroenterology-distinguished-global-lecture-2015
#15
Khean-Lee Goh
Colorectal cancer (CRC), gastroesophageal reflux disease (GERD), inflammatory bowel disease (IBD), and nonalcoholic fatty liver disease are considered important emerging diseases in the Asia Pacific (AP) region. The incidence rate of CRC is the highest among gastrointestinal cancers in the region surpassing that of gastric cancer. However, population CRC screening is limited by availability of adequate health resources and financing. GERD is a highly prevalent disease in AP with the prevalence of GERD symptoms and reflux esophagitis reported to be increasing...
July 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28582482/fusobacterium-and-colorectal-cancer-causal-factor-or-passenger-results-from-a-large-colorectal-cancer-screening-study
#16
Efrat L Amitay, Simone Werner, Marius Vital, Dietmar H Pieper, Daniela Höfler, Indra-Jasmin Gierse, Julia Butt, Yesilda Balavarca, Katarina Cuk, Hermann Brenner
Colorectal cancer is a leading cause of morbidity and mortality worldwide in both men and women. The gut microbiome is increasingly recognized as having an important role in human health and disease. Fusobacterium has been identified in former studies as a leading gut bacterium associated with colorectal cancer but it is still not clear if it plays an oncogenic role. In the current study, fecal samples were collected prior to bowel preparation from participants of screening colonoscopy in the German BliTz study...
June 5, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28576452/naldemedine-versus-placebo-for-opioid-induced-constipation-compose-1-and-compose-2-two-multicentre-phase-3-double-blind-randomised-parallel-group-trials
#17
Martin Hale, James Wild, Jyotsna Reddy, Tadaaki Yamada, Juan Camilo Arjona Ferreira
BACKGROUND: Opioid-induced constipation is a frequent side-effect of opioid treatment, and standard interventions have limited or inconsistent efficacy. This study assessed the efficacy and safety of naldemedine, a peripherally acting μ-opioid receptor antagonist, for the treatment of opioid-induced constipation in patients with chronic non-cancer pain. METHODS: We report two double-blind, randomised, placebo-controlled trials in adults with chronic non-cancer pain and opioid-induced constipation...
May 30, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28574322/volume-outcome-relationship-for-colorectal-cancer-in-primary-care-a-prospective-cohort-study
#18
David W Borowski, Sarah Cawkwell, Syed M Amir Zaidi, Matthew Toward, Nicola Maguire, Talvinder S Gill
Purpose Higher caseloads are associated with better outcomes for many conditions treated in secondary and tertiary care settings, including colorectal cancer (CRC). There is little known whether such volume-outcome relationship exist in primary care settings. The purpose of this paper is to examine general practitioner (GP) CRC-specific caseload for possible associations with referral pathways, disease stage and CRC patients' overall survival. Design/methodology/approach The paper retrospectively analyses a prospectively maintained CRC database for 2009-2014 in a single district hospital providing bowel cancer screening and tertiary rectal cancer services...
June 12, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28556580/a-family-history-questionnaire-sent-to-patients-prior-to-colonoscopy-enhances-genetic-counseling-for-hereditary-colorectal-cancer
#19
Koen Kessels, Joey D Eisinger, Tom G Letteboer, G Johan A Offerhaus, Peter D Siersema, Leon M G Moons
AIM: We investigated whether sending a family history questionnaire (FHQ) to patients prior to undergoing colonoscopy results in an increase of an available family history and genetic counseling. METHODS: A FHQ was sent by mail to patients before undergoing outpatient colonoscopy at a university hospital in 2013. Additional characteristics and referral for genetic evaluation of patients undergoing colonoscopy in 2013 were retrieved from the electronic medical record (EMR)...
May 29, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28525616/a-community-laboratory-drop-off-option-for-bowel-screening-test-kits-increases-participation-rates-results-from-an-interrupted-time-series-analysis
#20
P Sandiford, A Buckley, T Robinson, G Tozer, D Holdsworth, J Badkar
Background: Countries with population-based colorectal cancer screening using faecal occult blood test kits performed in the home and posted to the laboratory struggle to achieve higher than 60% uptake. We measured the impact on participation of offering a community laboratory drop-off (CLD) alternative to postal return in New Zealand's Bowel Screening Pilot. Methods: From May to September, 2015, a flyer added to the bowel screening test kit offered CLD as an alternative to returning the kit by post...
May 19, 2017: Journal of Public Health
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