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Bowel cancer screening

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https://www.readbyqxmd.com/read/28525616/a-community-laboratory-drop-off-option-for-bowel-screening-test-kits-increases-participation-rates-results-from-an-interrupted-time-series-analysis
#1
P Sandiford, A Buckley, T Robinson, G Tozer, D Holdsworth, J Badkar
Background: Countries with population-based colorectal cancer screening using faecal occult blood test kits performed in the home and posted to the laboratory struggle to achieve higher than 60% uptake. We measured the impact on participation of offering a community laboratory drop-off (CLD) alternative to postal return in New Zealand's Bowel Screening Pilot. Methods: From May to September, 2015, a flyer added to the bowel screening test kit offered CLD as an alternative to returning the kit by post...
May 19, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28524157/gp-participation-in-increasing-uptake-in-a-national-bowel-cancer-screening-programme-the-pearl-project
#2
Sally C Benton, Piers Butler, Katy Allen, Michelle Chesters, Sally Rickard, Sally Stanley, Richard Roope, Daniel Vulkan, Stephen W Duffy
BACKGROUND: The NHS Bowel Cancer Screening Programme (BCSP) in England does not involve general practitioners (GPs). Uptake is ∼58%. The Practice Endorsed Additional Reminder Letter (PEARL) study piloted a GP-endorsed reminder letter. METHODS: General practices in Wessex with uptake <55% (prevalent invitations) were invited to participate. Subjects who had been invited for screening, sent a standard 28-day BCSP reminder letter but had not returned a test kit within 30 days of the standard reminder were sent a second reminder letter bearing the GP's letterhead and signature...
May 18, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28523473/young-colorectal-cancer-patients-often-present-too-late
#3
Jia-Hao Law, Frederick H Koh, Ker-Kan Tan
PURPOSE: Current screening and health education strategies on colorectal cancer (CRC) remain focused on individuals >50 years old. However, CRC in young adults is not uncommon. This paper aims to explore how CRC presents in young adults and their clinical outcomes. METHODS: All patients aged <50 years diagnosed with CRC from January 2007 to December 2015 were reviewed. Patient demographics, clinical symptoms, and outcomes of treatment were collected. RESULTS: Of 1367 patients diagnosed with CRC, 154 (11...
May 18, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28511430/study-on-the-relation-between-colorectal-cancer-and-gall-bladder-disease
#4
Siddharth Gosavi, R Rama Mishra, Vsm Praveen Kumar
INTRODUCTION: Colorectal cancer is cancer of the large intestine, the lower part of digestive system which includes the sigmoid colon and rectum. AIM: To study the relation of incidence of colorectal cancer with previous gall bladder disease or post-cholecystectomy status, a relation between gall bladder disease and smoking in particular and the most common region of colon involved in colorectal cancer in gall bladder disease and non-gall bladder disease patients...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28490420/testing-the-effectiveness-of-a-primary-care-intervention-to-improve-uptake-of-colorectal-cancer-screening-a-randomized-controlled-trial-protocol
#5
Natalie Dodd, Mariko Leanne Carey, Elise Mansfield, Christopher Oldmeadow
BACKGROUND: Screening for colorectal cancer (CRC) significantly reduces mortality associated with this disease. In Australia, the National Bowel Cancer Screening Program provides regular fecal occult blood tests (FOBT) for those aged 50 to 74 years, however, participation rates in the program have plateaued at 36%. Given low uptake in the National Bowel Cancer Screening Program, it is necessary to explore alternate methods to increase CRC screening rates. Primary care is a promising adjunct setting to test methods to increase CRC screening participation...
May 10, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28470092/the-sept9-gene-methylation-assay-is-capable-of-detecting-colorectal-adenoma-in-opportunistic-screening
#6
Lele Song, Xiumei Peng, Yuemin Li, Wenhua Xiao, Jia Jia, Cheng Dong, Yuan Gong, Guangpeng Zhou, Xiaoliang Han
AIM: This study validated the detection of colorectal adenoma in opportunistic screening using the SEPT9 gene methylation assay. MATERIALS & METHODS: Plasma samples including 85 colorectal cancers, 364 adenomas, 216 hyperplastic polyps, 372 other gastrointestinal diseases and 324 normal subjects, were obtained and tested using the Epi proColon 2.0 CE assay. RESULTS & CONCLUSION: The SEPT9 assay detected 38.7% of all types of adenoma, including 27...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28469357/healthcare-maintenance-in-elderly-patients-with-inflammatory-bowel-disease
#7
REVIEW
Manish P Shrestha, Joannie Ruel, Sasha Taleban
The increasing number of older patients (age ≥60 years) with inflammatory bowel disease (IBD) highlights the importance of healthcare maintenance in this vulnerable population. Older IBD patients are more susceptible and have higher rates of many disease- and treatment-related adverse effects. Compared to younger IBD patients, older patients are at increased risk for infection, malignancy, bone disease, eye disease, malnutrition and thrombotic complications. Preventive strategies in the elderly differ from those in younger adults and are imperative...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28467146/high-test-positivity-and-low-positive-predictive-value-for-colorectal-cancer-of-continued-faecal-occult-blood-test-screening-after-negative-colonoscopy
#8
Jeremy P Brown, Kate Wooldrage, Suzanne Wright, Claire Nickerson, Amanda J Cross, Wendy S Atkin
Objectives The English Bowel Cancer Screening Programme offers biennial guaiac faecal occult blood test (gFOBT) screening to 60-74-year-olds. Participants with positive results are referred for follow-up, but many do not have significant findings. If they remain age eligible, these individuals are reinvited for gFOBT screening. We evaluated the performance of repeat screening in this group. Methods We analysed data on programme participants reinvited to gFOBT screening after either previous negative gFOBT ( n = 327,542), or positive gFOBT followed by a diagnostic investigation negative for colorectal cancer (CRC) or adenomas requiring surveillance ( n = 42,280)...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28464213/increasing-colonoscopy-screening-in-disparate-populations-results-from-an-evaluation-of-patient-navigation-in-the-new-hampshire-colorectal-cancer-screening-program
#9
Ketra Rice, Lindsay Gressard, Amy DeGroff, Joanne Gersten, Janene Robie, Steven Leadbetter, Rebecca Glover-Kudon, Lynn Butterly
BACKGROUND: To investigate uniformly successful results from a statewide program of patient navigation (PN) for colonoscopy, this comparison study evaluated the effectiveness of the PN intervention by comparing outcomes for navigated versus non-navigated patients in one of the community health clinics included in the statewide program. Outcomes measured included screening completion, adequacy of bowel preparation, missed appointments and cancellations, communication of test results, and consistency of follow-up recommendations with clinical guidelines...
May 2, 2017: Cancer
https://www.readbyqxmd.com/read/28462518/alvimopan-for-recovery-of-bowel-function-after-radical-cystectomy
#10
REVIEW
Shahnaz Sultan, Bernadette Coles, Philipp Dahm
BACKGROUND: Alvimopan is used in abdominal surgery to reduce postoperative ileus in patients undergoing small bowel resections with primary anastomosis. The role and efficacy of alvimopan in patients undergoing radical cystectomy with urinary diversion is not well understood. OBJECTIVES: To assess the effects of alvimopan in the context of enhanced recovery pathways compared to enhanced recovery pathways alone for perioperative bowel dysfunction in patients undergoing radical cystectomy...
May 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28456708/who-requires-emergency-surgery-for-colorectal-cancer-and-can-national-screening-programmes-reduce-this-need
#11
Alan Askari, Subramanian Nachiappan, Andrew Currie, Alex Bottle, John Abercrombie, Thanos Athanasiou, Omar Faiz
INTRODUCTION: Patients undergoing emergency colorectal cancer (CRC) surgery are at higher risk of poor outcome than those managed electively. The aim of this national study is to identify groups at high risk of undergoing unplanned CRC surgery and assess short and long-term outcome in this cohort subsequent morbidity and mortality as well as quantify their long-term survival. The aim of this national study is to identify groups at high risk of undergoing unplanned CRC surgery and assess short and long-term outcome, subsequent morbidity and mortality as well as quantify their long-term survival...
April 27, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28451385/a-network-pharmacology-approach-to-establish-the-pharmacological-mechanism-of-jiaweixianjitang-on-inflammatory-bowel-disease
#12
Ling-Jia Tao, Wen-Ting Chen, Lin Jing, Qing Ji, Jian-Lin Ren
The aim of the present study was to characterize the molecular mechanism of the effective components of JiaWeiXianJiTang (JWXJT), a traditional Chinese medicine, on inflammatory bowel disease (IBD) using network pharmacology technology. Data regarding natural molecules of JWXJT, targets of IBD, and interactions between natural molecules and IBD targets were screened. Network pharmacology of the interactions between natural molecules and IBD targets were drawn using Cytoscape v3.2.1. As a result of screening, 205 interactions were identified between 673 natural molecules and 76 targets of IBD...
March 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28445263/acupuncture-for-enhancing-early-recovery-of-bowel-function-in-cancer-protocol-for-a-systematic-review
#13
Yi-Hua Liu, Yang Ye, Jia-Bin Zheng, Xue-Qian Wang, Ying Zhang, Hong-Sheng Lin
BACKGROUND: Cancer patients undergoing surgical procedure often suffer from bowel dysfunction and postoperative ileus (POI). Cancer management for early recovery of bowel function is still a challenging topic. Acupuncture has been commonly used in a variety of gastrointestinal diseases. The aim of this study is to evaluate the effects of acupuncture therapy to reduce the duration of POI and enhance bowel function in cancer patients. METHODS: We will systematically screen all randomized controlled trials (RCTs) published through electronically and hand searching...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28441381/text-message-reminders-in-colorectal-cancer-screening-triccs-a-randomised-controlled-trial
#14
Yasemin Hirst, Hanna Skrobanski, Robert S Kerrison, Lindsay C Kobayashi, Nicholas Counsell, Natasha Djedovic, Josephine Ruwende, Mark Stewart, Christian von Wagner
BACKGROUND: We investigated the effectiveness of a text-message reminder to improve uptake of the English Bowel Cancer Screening programme in London. METHODS: We performed a randomised controlled trial across 141 general practices in London. Eight thousand two hundred sixty-nine screening-eligible adults (aged 60-74 years) were randomised in a 1 : 1 ratio to receive either a text-message reminder (n=4134) or no text-message reminder (n=4135) if they had not returned their faecal occult blood test kit within 8 weeks of initial invitation...
May 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28426464/comparative-effectiveness-in-urology-a-state-of-the-art-review-utilizing-a-systematic-approach
#15
Jathin Bandari, Charles B Wessel, Bruce L Jacobs
PURPOSE OF REVIEW: Comparative effectiveness research plays a vital role in healthcare delivery by guiding evidence-based practices. We performed a state-of-the-art review of comparative effectiveness research in the urology literature for 2016, utilizing a systematic approach. Seven high-impact papers are reviewed in detail. RECENT FINDINGS: Across the breadth of urology, there were several important studies in comparative effectiveness research, of which we will highlight two randomized controlled trials and five observational trials: radiotherapy, prostatectomy, and active monitoring have equivalent mortality outcomes in patients with localized prostate cancer; the ideal modality of patient education is yet to be determined, and written education has minimal effect on patient perception of prostate specific antigen screening; robotic prostatectomy is associated with higher perioperative complication rates on a population basis; racial disparities exist in incontinence rates after treatment for localized prostate cancer, but not in irritative, bowel, or sexual function; androgen deprivation therapy is associated with higher fracture, peripheral artery disease, and cardiac-related complications than bilateral orchiectomy; robotic and open cystectomy offer comparable cancer-specific mortality and perioperative outcomes; and bonuses for low-cost hospitals can inadvertently reward low-quality hospitals...
April 19, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28422369/what-impact-do-questionnaire-length-and-monetary-incentives-have-on-mailed-health-psychology-survey-response
#16
Kathryn A Robb, Lauren Gatting, Jane Wardle
OBJECTIVES: Response rates to health-related surveys are declining. This study tested two strategies to improve the response rate to a health psychology survey mailed through English general practices: (1) sending a shortened questionnaire and (2) offering a monetary incentive to return a completed questionnaire. DESIGN: Randomized controlled trial. METHODS: Adults (n = 4,241) aged 45-59 years, from four General Practices in South-East England, were mailed a survey on attitudes towards bowel cancer screening...
April 19, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28421339/small-bowel-adenocarcinoma-complicating-crohn-s-disease-a-single-centre-experience-emphasizing-the-importance-of-screening-for-dysplasia
#17
Chloé Grolleau, Nicolas M Pote, Nathalie S Guedj, Magaly Zappa, Nathalie Theou-Anton, Yoram Bouhnik, Yves Panis, Dominique L Cazals-Hatem
Small bowel adenocarcinoma (SBA) complicating Crohn's disease (CD) is rare and generally found incidentally on surgical specimens. We report our experience in CD-associated SBA observed this last decade in a tertiary referral centre in order to update its incidence, clinical presentation and pathological features. All SBAs diagnosed in patients who underwent surgery for CD between 2006 and 2016 were retrospectively included. Clinico-pathological characteristics were reviewed, and follow-up was updated. SBA was diagnosed in 9 (1...
April 18, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28420378/a-cross-sectional-survey-assessing-factors-associated-with-reading-cancer-screening-information-previous-screening-behaviour-demographics-and-decision-making-style
#18
Alex Ghanouni, Cristina Renzi, Jo Waller
BACKGROUND: There is broad agreement that cancer screening invitees should know the risks and benefits of testing before deciding whether to participate. In organised screening programmes, a primary method of relaying this information is via leaflets provided at the time of invitation. Little is known about why individuals do not engage with this information. This study assessed factors associated with reading information leaflets provided by the three cancer screening programmes in England...
April 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28412271/impact-of-a-new-distal-attachment-on-colonoscopy-performance-in-an-academic-screening-center
#19
Zacharias P Tsiamoulos, Ravi Misra, Rajaratanam Rameshshanker, Timothy R Elliott, Iosif Beintaris, Siwan Thomas-Gibson, Adam Haycock, Noriko Suzuki, Colin Rees, Brian P Saunders
BACKGROUND AND AIMS: Distal attachments placed on the colonoscope tip may positively affect performance by assisting insertion and polyp detection. The Endocuff-original appears to improve adenoma detection rate, but there are no data assessing the performance of the second generation Endocuff-vision. METHODS: A pilot service evaluation study (April-2013/September-2014) was conducted on patients with positive faecal occult blood tests within the National Bowel Cancer Programme during 3 consecutive periods: pre-cuff/no device used, during-cuff/device used and post-cuff/no device used...
April 12, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28379306/anal-neoplasia-in-inflammatory-bowel-disease-classification-proposal-epidemiology-carcinogenesis-and-risk-management-perspectives
#20
Andrew Wisniewski, Jean-Francois Fléjou, Laurent Siproudhis, Laurent Abramowitz, Magali Svrcek, Laurent Beaugerie
Patients with inflammatory bowel disease [IBD] may develop, similarly to individuals from general population, rare cases of human papilloma virus [HPV]-related anal canal squamous cell carcinoma [SCC] and intra-epithelial precursor lesions, as well as very rare cases of anal canal adenocarcinoma. Patients with chronic perianal Crohn's disease [CD] are at substantial risk of developing SCC or adenocarcinoma from the fistula-lining epithelium, as well as SCC or adenocarcinoma arising from chronic anorectal ulcerations or strictures...
March 30, 2017: Journal of Crohn's & Colitis
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