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https://www.readbyqxmd.com/read/29774162/a-large-proportion-of-fecal-immunochemical-test-positive-participants-in-colorectal-cancer-screening-is-symptomatic
#1
Clasine M de Klerk, Manon van der Vlugt, Patrick M Bossuyt, Evelien Dekker
Background: Symptomatic invitees are advised not to participate in colorectal cancer (CRC) screening but to directly consult their general practitioner (GP), because fecal immunochemical test (FIT) sensitivity for cancer is not optimal. This recommendation may not always be followed in daily practice. We evaluated how many FIT-positive participants had CRC-related symptoms and whether the presence of symptoms was associated with the presence and location of CRC/advanced neoplasia. Methods: We prospectively collected data on CRC-related symptoms in all FIT-positive participants in the Dutch CRC screening program, referred to our endoscopy centers between 2014 and 2016, and evaluated whether symptoms were associated with detected CRC/advanced neoplasia at colonoscopy...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29771698/updates-in-colorectal-cancer-screening-in-inflammatory-bowel-disease
#2
William T Clarke, Joseph D Feuerstein
PURPOSE OF REVIEW: This review article will discuss the risk of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD), as well as the current recommendations for CRC screening and surveillance in patients with ulcerative colitis or Crohn's colitis involving one-third of the colon. RECENT FINDINGS: Given that most cases of CRC are thought to arise from dysplasia, previous guidelines have recommended endoscopic surveillance with random biopsies obtained from all segments of the colon...
May 15, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29738352/the-effect-of-obesity-on-the-quality-of-bowel-preparation-for-colonoscopy-results-from-a-large-observational-study
#3
Ava B Anklesaria, Elena A Ivanina, Kenechukwu O Chudy-Onwugaje, Kevin Tin, Chaya M Levine, Peter Homel, Mary Rojas, Ira E Mayer, Rabin Rahmani
BACKGROUND: Obesity has been linked to suboptimal bowel preparation but this association has not been conclusively investigated in prospective studies. GOALS: Our objective was to determine whether any relationship exists between obesity as measured by body mass index (BMI) and quality of bowel preparation. STUDY: Adult patients who presented for outpatient colonoscopy at a single urban ambulatory surgery center within a 6-month period and fulfilled inclusion criteria were prospectively enrolled for the study...
May 5, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29730633/use-of-a-gp-endorsed-12-months-reminder-letter-to-promote-uptake-of-bowel-scope-screening-protocol-for-a-randomised-controlled-trial-in-a-hard-to-reach-population
#4
Christian von Wagner, Yasemin Hirst, Sara Tookey, Robert S Kerrison, Sarah Marshall, Andrew Prentice, Daniel Vulkan, Una Macleod, Stephen Duffy
INTRODUCTION: Flexible sigmoidoscopy (FS) screening is associated with reduced colorectal cancer incidence and mortality when offered as a one-off test to men and women aged 55-64. The test, also referred to as the 'bowel scope screening' (BSS) test, was added to England's national Bowel Cancer Screening Programme in March 2013, where it is offered to men and women aged 55. Since its implementation, uptake of the BSS test has been low, with only 43% of the eligible population attending an appointment...
May 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29727905/detection-of-clinically-relevant-serrated-polyps-during-screening-colonoscopy-results-from-seven-cooperating-centers-within-the-german-colorectal-screening-program
#5
Christoph Schramm, Katharina Janhsen, Jan-Hinnerk Hofer, Hans Toermer, Annette Stelzer, Frank Stenschke, Michael Stollenwerk, Ingo Scheller, Sonja Lang, Tobias Goeser, Hans-Michael Steffen
BACKGROUND:  Serrated polyps have been recognized as precursors of colorectal cancer (CRC) via the serrated pathway. Endoscopic detection and histopathological evaluation of serrated polyps are challenging. The aims of this study were to determine detection rates of the recently proposed entity of clinically relevant serrated polyps (crSPs) and to identify factors that influence their detection in a primary colonoscopy screening cohort. METHODS:  We retrospectively analyzed average-risk screening colonoscopies performed at a tertiary academic hospital and six community-based private practices in Germany between 01/01/2012 and 14/12/2016...
May 4, 2018: Endoscopy
https://www.readbyqxmd.com/read/29720112/emotional-predictors-of-bowel-screening-the-avoidance-promoting-role-of-fear-embarrassment-and-disgust
#6
Lisa M Reynolds, Ian P Bissett, Nathan S Consedine
BACKGROUND: Despite considerable efforts to address practical barriers, colorectal cancer screening numbers are often low. People do not always act rationally, and investigating emotions may offer insight into the avoidance of screening. The current work assessed whether fear, embarrassment, and disgust predicted colorectal cancer screening avoidance. METHODS: A community sample (N = 306) aged 45+ completed a questionnaire assessing colorectal cancer screening history and the extent that perceptions of cancer risk, colorectal cancer knowledge, doctor discussions, and a specifically developed scale, the Emotional Barriers to Bowel Screening (EBBS), were associated with previous screening behaviours and anticipated bowel health decision-making...
May 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29716410/screening-for-colorectal-cancer-in-defunctioned-colons
#7
Fayyaz Akbar, Aaron Quyn, Robert Steele
Objectives Population-based colorectal (bowel) cancer screening using faecal occult blood tests leads to a reduction in cause-specific mortality. However, in people where the colon is defunctioned, the use of standard faecal occult blood test is not appropriate. The aim of this study was to examine the current trends of clinical practice for colorectal cancer screening in people with defunctioned colons. Methods An online survey was performed using SurveyMonkey. All members of the Association of Coloproctology of Great Britain and Ireland were invited by email to participate...
January 1, 2018: Journal of Medical Screening
https://www.readbyqxmd.com/read/29713987/low-rates-of-dermatologic-care-and-skin-cancer-screening-among-inflammatory-bowel-disease-patients
#8
Alyce Anderson, Laura K Ferris, Benjamin Click, Claudia Ramos-Rivers, Ioannis E Koutroubakis, Jana G Hashash, Michael Dunn, Arthur Barrie, Marc Schwartz, Miguel Regueiro, David G Binion
BACKGROUND: Dermatologic manifestations of inflammatory bowel disease (IBD) are common, and certain IBD medications increase the risk of skin cancer. AIMS: To define the rates of care and factors associated with dermatologic utilization with a focus on skin cancer screening. METHODS: We utilized a prospective, natural history IBD research registry to evaluate all outpatient healthcare encounters from 2010 to 2016. Gastrointestinal, dermatologic and primary care visits per individual were identified...
April 30, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29706374/risk-of-gastrointestinal-cancers-in-patients-with-cystic-fibrosis-a-systematic-review-and-meta-analysis
#9
Akihiro Yamada, Yuga Komaki, Fukiko Komaki, Dejan Micic, Samantha Zullow, Atsushi Sakuraba
BACKGROUND: The management and life expectancy of patients with cystic fibrosis have improved substantially in the past three decades, which has resulted in an increased number of these patients being diagnosed with malignancies. Our aim was to assess the risk of gastrointestinal cancers in patients with cystic fibrosis. METHODS: In this systematic review and meta-analysis, we searched PubMed, MEDLINE, Google Scholar, Scopus, Embase, and Cochrane databases with no language restrictions for studies published from inception of the databases to Aug 1, 2017, assessing the risk of gastrointestinal cancers in patients with cystic fibrosis...
April 26, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29700559/-primary-sclerosing-cholangitis-current-diagnostics-and-treatment
#10
REVIEW
T Liwinski, C Schramm
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown etiology. Characteristic features are multifocal strictures and dilatations of the bile ducts. In 60-80 % of cases the PSC is strongly associated with chronic inflammatory bowel disease, mostly in the form of pancolitis. The diagnosis is established based on detection of typical cholangiographic lesions of the bile ducts and exclusion of secondary causes of sclerosing cholangitis. There is no approved medical treatment, but in Germany ursodeoxycholic acid is frequently used...
April 26, 2018: Der Internist
https://www.readbyqxmd.com/read/29696062/iron-deficiency-in-a-tertiary-gastroenterology-center-in-romania-prevalence-and-significancy
#11
Carmen Monica Preda, Doina Proca, Irina Sandra, Boroka Claudia Horeanga, Larisa Elena Fulger, Teodora Manuc, Ion Bancila, Oana Elena Balas, Mircea Manuc, Mircea Diculescu, Cristian Baicus, Cristian Tieranu, Ileana Constantinescu
Introduction: Iron deficiency has been known to cause significant functional impairment, lower quality of life and higher morbidity and mortality. The aim of this study was to estimate the prevalence and significance of iron deficiency in our patients and medical staff. Material and methods: We performed a prospective cross-sectional study: In July 2016, 383 persons were screened for the presence of iron deficiency (ID): 325 patients and 58 people from the medical staff. Transferrin saturation (TSAT), serum ferritin (SF) and complete blood count were performed...
January 2018: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29675414/spondyloarthritis-acute-anterior-uveitis-and-fungi-updating-the-catterall-king-hypothesis
#12
Martin Laurence, Mark Asquith, James T Rosenbaum
Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. The HLA-B*27 allele group, which presents intracellular peptides to CD8+ T cells, is by far the strongest risk factor for spondyloarthritis. The precise mechanisms and antigens remain unknown. In 1959, Catterall and King advanced a novel hypothesis explaining the etiology of spondyloarthritis: an as-yet-unrecognized sexually acquired microbe would be causing all spondyloarthritis types, including acute anterior uveitis...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29668929/chromoendoscopy-for-dysplasia-surveillance-in-inflammatory-bowel-disease
#13
Ann D Flynn, John F Valentine
Long-standing ulcerative colitis (UC) and extensive Crohn's colitis confer increased risk for development of colorectal cancer. Screening and surveillance colonoscopy programs aim to identify, resect, or detect dysplasia or colorectal cancer. Dysplastic lesions can be removed by endoscopic resection and patients with unresectable lesions can be referred for colectomy at an earlier stage, with the goal of reducing overall morbidity and mortality from colorectal cancer. Surveillance colonoscopy for patients with inflammatory bowel disease (IBD) is endorsed by multiple specialty societies...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29666967/health-maintenance-in-inflammatory-bowel-disease
#14
REVIEW
Fazia A Mir, Sunanda V Kane
PURPOSE OF REVIEW: Patients with inflammatory bowel disease (IBD) are not receiving preventative care services at the same rate as the general population. IBD patients are at increased risk for infections, osteoporosis, and certain malignancies secondary to their disease and as they are on immunosuppressive therapy. They are a younger population and often times consider their gastroenterologist as their primary care physician. In this review, we discuss up-to-date evidence pertaining to vaccine-preventable illnesses in the immunosuppressed IBD patient, screening for bone health, cervical cancer, skin malignancies, psychological wellbeing, and smoking cessation...
April 17, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29645077/a-symptom-based-model-to-predict-colorectal-cancer-in-low-resource-countries-results-from-a-prospective-study-of-patients-at-high-risk-for-colorectal-cancer
#15
Olusegun Isaac Alatise, Omobolaji O Ayandipo, Ademola Adeyeye, Ken Seier, Akinwunmi O Komolafe, Matthew O Bojuwoye, Oludapo O Afuwape, Ann Zauber, Adeleye Omisore, Samuel Olatoke, Adegboyega Akere, Olusola Famurewa, Mithat Gonen, David O Irabor, T Peter Kingham
BACKGROUND: Colorectal cancer (CRC) rates in low-resource countries, which typically lack CRC screening programs, are rising. This study determined whether a risk model for patients with rectal bleeding could identify patients with curable CRC. METHODS: This prospective, cross-sectional study evaluated a model constructed from data from 1 hospital and validated at 2 other hospitals. The primary endpoint was the ability of the model to predict CRC, as diagnosed by colonoscopy, from clinical characteristics...
April 12, 2018: Cancer
https://www.readbyqxmd.com/read/29644509/applications-of-colon-capsule-endoscopy
#16
REVIEW
Shabana F Pasha
PURPOSE OF REVIEW: This is a review of colon capsule endoscopy (CCE) with a focus on its recent developments, technological improvements, and current and potential future indications. RECENT FINDINGS: Based on the current literature, CCE II demonstrates comparable polyp detection rates as optical colonoscopy and CT colonography, and improved cost-effectiveness. The main limitation to patient acceptance is the requirement of a rigorous bowel preparation. Preliminary studies show good correlation between CCE and optical colonoscopy for assessment of colonic disease activity in inflammatory bowel disease (IBD)...
April 12, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29628776/the-association-between-long-term-conditions-and-uptake-of-population-based-screening-for-colorectal-cancer-results-from-two-english-cohort-studies
#17
Benjamin Kearns, Jim Chilcott, Clare Relton, Sophie Whyte, Helen Buckley Woods, Claire Nickerson, Amanda Loban
Introduction: Uptake of screening for colorectal cancer (CRC) can reduce mortality, and population-based screening is offered in England. To date, there is little evidence on the association between having a long-term condition (LTC) and CRC screening uptake. The objective of this study was to examine the association between having an LTC and uptake of CRC screening in England with the guaiac fecal occult blood test, with a particular focus on common mental disorders. Methods: The study was a preregistered secondary analysis of two cohorts: first, a linked data set between the regional Yorkshire Health Study (YHS) and the National Health Service National Bowel Cancer Screening Program (BCSP, years 2006-2014); second, the national English Longitudinal Study of Ageing (ELSA, years 2014-2015)...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29609829/is-the-virtual-colonoscopy-a-replacement-for-optical-colonoscopy
#18
REVIEW
Andrew Guinigundo
OBJECTIVE: To examine the viability of colon cancer screening with computed tomography colonography, also known as virtual colonoscopy. DATA SOURCES: Clinical guidelines, published medical research. CONCLUSION: Virtual colonoscopy, under the right circumstances, is an accurate viable screening tool for patients who may not otherwise desire to or are not able to participate in traditional colonoscopy. IMPLICATIONS FOR NURSING PRACTICE: Nurses should be aware that routine colon cancer screening is recommended starting at age 50...
March 30, 2018: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/29609509/bowel-cancer-screening-for-women-at-midlife
#19
I Olver
In Australia one in 15 women will be diagnosed with colorectal cancer in their lifetime because of the high incidences of lifestyle risk factors. The risk could be reduced by taking aspirin. Evidence-based Clinical Practice Guidelines for the prevention, early detection and management of colorectal cancer produced by Cancer Council Australia and approved by the National Health and Medical Research Council recommended that 'population screening in Australia, directed at those at average risk of colorectal cancer and without relevant symptoms, is immunochemical fecal occult blood testing every 2 years, starting at age 50 years and continuing to age 74 years...
April 3, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29605092/evaluation-of-a-vaccination-regimen-and-care-in-relation-to-follow-up-and-treatment-of-patients-with-inflammatory-bowel-disease
#20
J K Yamamoto-Furusho, A Sarmiento-Aguilar, N N Parra-Holguín, K E Bozada-Gutiérrez
INTRODUCTION AND AIMS: During the clinical course of inflammatory bowel disease, different causes can compromise kidney, liver, and bone marrow function and increase the risk for osteoporosis, infections, and neoplasias. The aim of the present study was to describe the follow-up of Mexican patients with inflammatory bowel disease in relation to their vaccination regimen, treatment-associated risks, and cancer screening. MATERIALS AND METHODS: A retrospective cross-sectional study was conducted within the time frame of February and June 2017...
March 28, 2018: Revista de Gastroenterología de México
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