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https://www.readbyqxmd.com/read/28525614/intravenous-lidocaine-alleviates-the-pain-of-propofol-injection-by-local-anesthetic-and-central-analgesic-effects
#1
Jibin Xing, Ling Liang, Shaoli Zhou, Chenfang Luo, Jun Cai, Ziqing Hei
Objective. : Lidocaine alleviates propofol injection pain. However, whether lidocaine works through a local anesthetic effect at the site of intravenous injection or through a systemic effect on the central nervous system remains unknown. This study aimed to determine the pain-alleviating mechanism of lidocaine. Design. : A randomized controlled study. Setting. : A gastroscopy facility. Methods. : The study was divided into two parts...
May 19, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28522785/infeasibility-of-endoscopic-transmural-drainage-due-to-pancreatic-pseudocyst-wall-calcifications-case-report
#2
Andrzej Krajewski, Gustaw Lech, Marcin Makiewicz, Andrzej Kluciński, Monika Wojtasik, Sławomir Kozieł, Maciej Słodkowski
Postinflammatory pancreatic pseudocysts are one of the most common complications of acute pancreatitis. In most cases, pseudocysts self-absorb in the course of treatment of pancreatitis. In some patients, pancreatic pseudocysts are symptomatic and cause pain, problems with gastrointestinal transit, and other complications. In such cases, drainage or resection should be performed. Among the invasive methods, mini invasive procedures like endoscopic transmural drainage through the wall of the stomach or duodenum play an important role...
February 28, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28514928/challenges-in-evaluation-of-screening-for-gastric-cancer-among-men-based-on-nonrandomized-design
#3
Ilkka Vohlonen, Matti Härkönen, Nea Malila, Eero Pukkala, Pentti Sipponen, Veli Koistinen, Matti Hakama
BACKGROUND: Objective was to quantify biases in screening for gastric cancer when comparing attenders to nonattenders using serum pepsinogen I (SPGI) level as primary test. METHODS: In mid 1990s, all men aged 51-65 years from two Finnish cities were invited to SPGI screening. Mortality and premature mortality in attenders were compared to nonattenders. Efficacy of screening was studied by 15 years' follow-up of standardized mortality ratio (SMR) and potential years of life lost (PYLL) due to gastric cancer...
July 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28507905/gastric-syphilis
#4
Jianfei Cai, Danian Ji, Jian-Long Guan
Syphilis is a chronic systemic infectious disease. Gastric involvement is uncommon. We report of a 55-year-old female patient with a history of epigastric pain and a diagnosis of Syphilis confirmed by main clinical symptoms, tolulized red unheated serum test(TRUST) and treponema pallidum hemagglutination assay(TPHA). At the same time, we still reported gastric involvement about syphilis in this patient with gastroscopy and pathology.
2017: IDCases
https://www.readbyqxmd.com/read/28506538/epitope-specific-immunotherapy-targeting-cd4-positive-t-cells-in-coeliac-disease-two-randomised-double-blind-placebo-controlled-phase-1-studies
#5
Gautam Goel, Tim King, A James Daveson, Jane M Andrews, Janakan Krishnarajah, Richard Krause, Gregor J E Brown, Ronald Fogel, Charles F Barish, Roger Epstein, Timothy P Kinney, Philip B Miner, Jason A Tye-Din, Adam Girardin, Juha Taavela, Alina Popp, John Sidney, Markku Mäki, Kaela E Goldstein, Patrick H Griffin, Suyue Wang, John L Dzuris, Leslie J Williams, Alessandro Sette, Ramnik J Xavier, Ludvig M Sollid, Bana Jabri, Robert P Anderson
BACKGROUND: A gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to gluten. We developed a therapeutic vaccine, Nexvax2, designed to treat coeliac disease. Nexvax2 is an adjuvant-free mix of three peptides that include immunodominant epitopes for gluten-specific CD4-positive T cells. The vaccine is intended to engage and render gluten-specific CD4-positive T cells unresponsive to further antigenic stimulation. We assessed the safety and pharmacodynamics of the vaccine in patients with coeliac disease on a gluten-free diet...
May 11, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28503076/positive-predictive-value-of-peptic-ulcer-diagnosis-codes-in-the-danish-national-patient-registry
#6
Søren Viborg, Kirstine Kobberøe Søgaard, Peter Jepsen
BACKGROUND: Diagnoses of peptic ulcer are registered in the Danish National Patient Registry (DNPR) for administrative as well as research purposes, but it is unknown whether the coding validity depends on the location of the ulcer. OBJECTIVE: To validate the International Classification of Diseases, 10(th) revision diagnosis codes of peptic ulcer in the DNPR by estimating positive predictive values (PPVs) for gastric and duodenal ulcer diagnoses. METHODS: We identified all patients registered with a hospital discharge diagnosis of peptic ulcer from Aarhus University Hospital, Denmark, in 1995-2006...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28493007/gastrointestinal-endoscopy-in-patients-receiving-novel-direct-oral-anticoagulants-results-from-the-prospective-dresden-noac-registry
#7
Vera Heublein, Sven Pannach, Katharina Daschkow, Luise Tittl, Jan Beyer-Westendorf
BACKGROUND: Patients receiving direct-acting, non-vitamin K oral anticoagulants (NOAC) frequently undergo gastrointestinal endoscopies (GIE) but little is known on the management and outcome of these interventions. METHODS: With use of data from an ongoing, prospective, noninterventional registry of NOAC patients, the management and outcome of GIE were evaluated with use of standard event definitions. Patients undergoing GIE were categorized into two subgroups: (1) scheduled GIE (scheduled appointment, no acute bleeding) and (2) unscheduled GIE (unscheduled including management of acute gastrointestinal bleeding)...
May 10, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28482406/-a-prognostic-analysis-of-cirrhotic-esophageal-variceal-bleeding-treated-with-standardized-endoscopic-therapy
#8
Y P Dai, Q Gao
Objective: To analyze the clinical effect of standardized endoscopic esophageal variceal ligation alone or in combination with tissue adhesive injection for gastric varices (GV) after the first cirrhotic esophageal variceal bleeding. Methods: A total of 97 patients who underwent a successful endoscopic therapy in our hospital due to the first cirrhotic esophageal variceal bleeding were enrolled, and according to the subsequent therapeutic regimen, they were divided into control group (48 patients) and treatment group (49 patients)...
March 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28480723/extrinsic-esophageal-compression-by-the-vertebral-body
#9
Laura Santos Santamaría, Mercedes Pérez Carreras, José Díaz-Tasende, Gregorio Castellano Tortajada
A 78-year-old woman with hypertension, diabetes, dyslipidemia, and revascularized ischemic heart disease was diagnosed with gastric adenocarcinoma in 2011, with suspected bilateral adrenal metastatic disease, and was treated with subtotal gastrectomy and palliative chemotherapy. A follow-up gastroscopy in 2015 identified a protruding, erosive mid-esophageal lesion suggestive of extrinsic compression or ulcerated submucosal lesion, which had not been described previously. Follow-up was advised, and the lesion persisted after three months...
May 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28471974/a-case-report-of-blunt-gastric-perforation-treated-with-endoscopic-clip-closure
#10
Ke Li, Xuelian Sun, Guoxing Wang
RATIONALE: Gastroscopymay not only allow identification of gastric injury, but may also facilitate prompt repair. PATIENT CONCERNS: A 39-year-old male patient was admitted 3 hours after abdominal injury caused by penetration of a screwdriver. Physical examination and computed tomography showed no evidence of gastric injury. However, 3000 mL fresh blood was vomited during the subsequent observation period. DIAGNOSES: Gastroscopy identified a ruptured artery and gastric perforation...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28461064/evaluation-of-transabdominal-ultrasound-with-oral-cellulose-based-contrast-agent-in-the-detection-and-surveillance-of-gastric-ulcer
#11
Zhijun Liu, Jintao Guo, Shupeng Wang, Ying Zhao, Zhining Liu, Jing Li, Weidong Ren, Shaoshan Tang, Limei Xie, Ying Huang, Siyu Sun, Liping Huang
The aim of this study was to assess the role of transabdominal ultrasound with cellulose-based oral contrast agent (TUS-OCCA) in the detection and surveillance of gastric ulcer. The study was approved by the institutional review board at Shengjing Hospital of China Medical University. A total of 124 consecutive patients with benign gastric ulcer diagnosed by gastroscopy and biopsy were enrolled. Serial TUS-OCCA (approximately 1 exam every 2 wk) was performed to monitor the effects of treatment, and additional interventions were planned according to the results...
April 28, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28455161/outcomes-of-screening-gastroscopy-in-first-degree-relatives-of-patients-fulfilling-hereditary-diffuse-gastric-cancer-criteria
#12
Rachel S van der Post, Jolanda van Dieren, Anna Grelack, Nicoline Hoogerbrugge, Lizet E van der Kolk, Petur Snaebjornsson, Iris Lansdorp-Vogelaar, J Han van Krieken, Tanya M Bisseling, Annemieke Cats
BACKGROUND AND AIMS: The aim of this study was to determine the yield of endoscopic screening in first-degree relatives (FDR) of CDH1-negative hereditary diffuse gastric cancer (HDGC) patients. METHODS: Retrospective observational cohort study. In 2 expert centers in the Netherlands data were collected on FDR from families fulfilling the international HDGC criteria that underwent endoscopic screening. Extensive inspection of the stomach was performed by gastroscopy, taking random and/or targeted stomach biopsy specimens to identify diffuse-type gastric cancer...
April 25, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28440099/antibiotic-susceptibility-of-helicobacter-pylori-in-iceland
#13
Anna Ingibjorg Gunnarsdottir, Hallgrimur Gudjonsson, Hjordis Hardardottir, Karen Drofn Jonsdottir, Einar Stefan Bjornsson
BACKGROUND: Increasing resistance of Helicobacter pylori (H. pylori) to antibiotics calls for constant re-evaluation of multidrug regimens that have been used to eradicate the infection. The aim of this study was to evaluate the current antibiotic susceptibility of H. pylori in an Icelandic cohort. METHODS: Patients referred for gastroscopy were recruited prospectively. Those found to have a positive rapid urease test were included in the study. Susceptibility testing was conducted by the Epsilometer test (E-test) method for ampicillin, clarithromycin, levofloxacin, metronidazole and tetracycline...
April 25, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28431636/systemic-air-embolism-after-endoscopy-without-vessel-injury-a-summary-of-reported-cases
#14
Peter Voigt, Stefan Schob, Sebastian Gottschling, Thomas Kahn, Alexey Surov
INTRODUCTION: Systemic air embolism (SAE) is a rare but serious complication following endoscopic procedures. It may occur with or without direct vessel injury. The aim of this work is to review cases of SAE following endoscopy without proven vessel injury. METHODS: In this systematic review PubMed database was screened for SAE following endoscopy from 1990 to 2015. Only cases without proven major vessel injury were included in the analysis. Including one case of SAE after colonoscopy from our hospital the analysis comprised 40 cases...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28405696/-varicella-gastritis-under-immunosuppression-case-report-of-a-woman-after-lung-transplantation-due-to-granulomatosis-with-polyangiitis
#15
S Saman, J-C Henes, D Niepel, H Bosmüller, C R Werner, U M Lauer, N P Malek, T Xenitidis
A 35-year-old woman who had previously undergone a lung transplantation presented with severe abdominal pain and vomiting. The gastroscopy showed diffuse ulcerative gastric lesions. Tests for varicella zoster virus and Epstein-Barr virus via polymerase chain reactions (PCR) on endoscopically obtained gastric biopsies were found to be positive and confirmed varicella gastritis. Intravenous antiviral therapy with acyclovir was administered resulting in a normalization of all clinical symptoms, especially of abdominal pain and inflammation parameters...
April 12, 2017: Der Internist
https://www.readbyqxmd.com/read/28397996/preliminary-investigations-into-a-novel-long-acting-injectable-intra-muscular-formulation-of-omeprazole-in-the-horse
#16
B W Sykes, K Kathawala, Y Song, S Garg, S W Page, C Underwood, P C Mills
REASONS FOR PERFORMING STUDY: Pilot investigations have suggested that a novel, long-acting, injectable, intra-muscular formulation of omeprazole (LA-OMEP) can induce acid suppression for up to 7 days following a single injection. OBJECTIVES: To investigate the pharmacodynamics and assess the clinical efficacy of the LA-OMEP formulation. STUDY DESIGN: Part A) A pharmacodynamic study; Part B) A pilot clinical trial. METHODS: Part A) Six adult, Thoroughbred horses with percutaneous gastrotomy tubes were used...
April 11, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28375483/esophageal-cancer-s-100-most-influential-manuscripts-a-bibliometric-analysis
#17
A G M T Powell, D L Hughes, J Brown, M Larsen, J Witherspoon, W G Lewis
Bibliometric analysis highlights key topics and publications that have shaped the understanding and management of esophageal cancer (EC). Here, the 100 most cited manuscripts in the field of EC are analyzed. The Thomson Reuters Web of Science database with the search terms 'esophageal cancer' or 'esophageal carcinoma' or 'oesophageal cancer' or 'oesophageal carcinoma' or 'gastroscopy' was used to identify all English language full manuscripts for the study. The 100 most cited papers were further analyzed by topic, journal, author, year, and institution...
April 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28375479/temporal-patterns-of-hiatus-hernia-recurrence-and-hiatal-failure-quality-of-life-and-recurrence-after-revision-surgery
#18
A Suppiah, P Sirimanna, S J Vivian, H O'Donnell, G Lee, G L Falk
Antireflux and paraesophageal hernia repair surgery is increasingly performed and there is an increased requirement for revision hiatus hernia surgery. There are no reports on the changes in types of failures and/or the variations in location of crural defects over time following primary surgery and limited reports on the outcomes of revision surgery. The aim of this study is to report the changes in types of hernia recurrence and location of crural defects following primary surgery, to test our hypothesis of the temporal events leading to hiatal recurrence and aid prevention...
April 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28374495/genome-wide-expression-profiling-and-bioinformatics-analysis-of-deregulated-genes-in-human-gastric-cancer-tissue-after-gastroscopy
#19
Yudi Mao, Qihong Zhao, Shi Yin, Xiping Ding, Hua Wang
AIM: The aim of this study was to analyze the gene expression profile and biological processes enriched in gastric cancer. METHODS: We collected five human advanced gastric cancer tissues by gastroscopy and five peritumor normal tissues as controls and examined the gene expression changes by microarray. KEGG Orthology Based Annotation System annotation was used to identify pathways and biological processes regulated by the deregulated genes. Protein-protein interaction network analysis identified protein complex and functional modules...
April 4, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28358612/management-and-case-outcome-of-gastric-impaction-in-four-raptors-a-case-series
#20
Jeffrey R Applegate, Arnaud Van Wettere, Emily F Christiansen, Laurel A Degernes
Four captive raptors, an American kestrel ( Falco sparverius ), peregrine falcon ( Falco peregrinus ), golden eagle ( Aquila chrysaetos ), and barn owl ( Tyto alba ), were diagnosed with ventricular and/or proventricular foreign material impactions consisting of artificial turf substrate, paper and plastic substrate, grass, and newspaper. Partial or total anorexia was reported in all birds and decreased casting in 2 birds. Survey radiographs confirmed presence of gastric enlargement in all 4 birds. The kestrel and eagle were treated unsuccessfully with gastroscopy and gastric lavage, respectively, followed by surgical intervention to remove the ventricular impactions...
March 2017: Journal of Avian Medicine and Surgery
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