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https://www.readbyqxmd.com/read/28342428/revealing-the-influence-of-glucocorticoid-treatment-on-the-excretion-of-anabolic-androgenic-steroids-in-horses-through-in-vitro-digestive-simulations-and-an-in-vivo-case-study
#1
Anneleen Decloedt, Sander Damen, Lynn Vanhaecke
Anabolic-androgenic steroids (AAS) are strictly forbidden in equine sports because of their stimulating effect on muscle growth and performance. Nevertheless, low levels of AAS have been found in some horses, untreated with AAS. Glucocorticoids (GC), used as an anti-inflammatory therapy and structurally related to AAS, might play a role in this phenomenon. In order to unravel this possible correlation the influence of glucocorticoid treatment on the excretion of AAS was studied both in vivo and in vitro. In vivo effects were investigated by analysing urine samples collected from a gelding treated with betamethasone...
February 24, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28337890/beneficial-effects-of-protein-hydrolysates-in-exercise-and-sports-nutrition
#2
J Yuan, B Jiang, K Li, W Shen, J L Tang
Protein hydrolysates (PH) are rich sources of proteins that supply the need of exercising muscles. PHs are enriched in di- and tripeptides and are better than free amino acids or intact proteins when muscle anabolic effect is considered. Digestion, absorption and muscle uptake of amino acids are faster and more efficient when PH is ingested in comparison to the respective intact protein. PHs not only enhance endurance in high intensity exercise regimen, but also help in faster post-exercise recovery of muscle by promoting glycogen synthesis, although the latter effect requires more convincing evidence...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337879/effects-of-human-parathyroid-hormone-on-bone-morphogenetic-protein-signal-pathway-following-spinal-fusion-in-diabetic-rats
#3
S Q Wu, S Z Ma, C Zhang, D Q Li, C Z Gao
Osteoporosis is a major complication in patients with diabetes mellitus. Thus, it is crucial to study the signal mechanisms responsible for enhancement of bone mass in diabetes. Administration of human parathyroid hormone (hPTH) has been reported to prevent osteoblast apoptosis and have anabolic effects on bone in animals and humans. In the present study, we examined the effects of hPTH on expression of bone morphogenetic protein type 2 (BMP-2) and its receptor BMPR2 in diabetic rats following spinal fusion...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337514/effect-of-sequential-treatment-with-bisphosphonates-after-teriparatide-in-ovariectomized-rats-a-direct-comparison-between-risedronate-and-alendronate
#4
Tetsuo Yano, Mei Yamada, Daisuke Inoue
Teriparatide (TPTD), a recombinant human parathyroid hormone N-terminal fragment (1-34), is a widely used bone anabolic drug for osteoporosis. Sequential treatment with antiresorptives such as bisphosphonates after TPTD discontinuation is generally recommended. However, relative effects of bisphosphonates have not been determined. In the present study, we directly compared effects of risedronate (RIS) and alendronate (ALN) on bone mineral density (BMD), bone turnover, structural property and strength in ovariectomized (OVX) rats, when administered after TPTD...
March 23, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28336831/-calcilytic-drugs-feature-and-future
#5
Itsuro Endo
Calcium-sensing receptor(CaSR)is highly expressed in parathyroid, kidney, bone, and small and large intestines to regulate Ca homeostasis. Calcilytics are allosteric antagonists of CaSR, and stimulate endogenous PTH release. Several calcilytics have been evaluated as anabolic therapies for postmenopausal osteoporosis but clinical development of all of them has been abandoned because the lacked clinical efficacy. Calcilytics might be repurposed for new indications like autosomal dominant hypocalcemia or other disorders...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28336748/the-sweet-side-of-ampk-signaling-regulation-of-gfat1
#6
John W Scott, Jonathan S Oakhill
Maintaining a steady balance between nutrient supply and energy demand is essential for all living organisms and is achieved through the dynamic control of metabolic processes that produce and consume adenosine-5'-triphosphate (ATP), the universal currency of energy in all cells. A key sensor of cellular energy is the adenosine-5'-monophosphate (AMP)-activated protein kinase (AMPK), which is the core component of a signaling network that regulates energy and nutrient metabolism. AMPK is activated by metabolic stresses that decrease cellular ATP, and functions to restore energy balance by orchestrating a switch in metabolism away from anabolic pathways toward energy-generating catabolic processes...
March 23, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28328712/resistance-training-induced-elevations-in-muscular-strength-in-trained-men-are-maintained-after-2-weeks-of-detraining-and-not-differentially-affected-by-whey-protein-supplementation
#7
Paul S Hwang, Thomas L Andre, Sarah K McKinley-Barnard, Flor E Morales Marroquín, Joshua J Gann, Joon J Song, Darryn S Willoughby
Hwang, PS, Andre, TL, McKinley-Barnard, SK, Morales Marroquín, FE, Gann, JJ, Song, JJ, and Willoughby, DS. Resistance training-induced elevations in muscular strength in trained men are maintained after 2 weeks of detraining and not differentially affected by whey protein supplementation. J Strength Cond Res 31(4): 869-881, 2017-Resistance training (RT) with nutritional strategies incorporating whey protein intake postexercise can stimulate muscle protein synthesis and elicit hypertrophy. The early phases of training-induced anabolic responses can be attenuated with longer-term training...
April 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28326342/short-term-intermittent-administration-of-parathyroid-hormone-facilitates-osteogenesis-by-different-mechanisms-in-cancellous-and-cortical-bone
#8
Kenji Ogura, Tadahiro Iimura, Yuji Makino, Ayano Sugie-Oya, Aya Takakura, Ryoko Takao-Kawabata, Toshinori Ishizuya, Keiji Moriyama, Akira Yamaguchi
Intermittent administration of human parathyroid hormone (1-34)[hPTH(1-34)] induces anabolic action on the bones. To understand the mechanism underlying the early phase of hPTH(1-34)-induced anabolic action, we investigated the expression profiles of osterix and sclerostin after short-term intermittent administration of hPTH(1-34) using immunohistochemistry in adult rats. In the cancellous bone, hPTH(1-34) administration greatly increased the number of osterix-positive cells in the bone marrow on day 1, but the cells gradually decreased on days 3 and 5...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28326339/glucose-dependent-insulinotropic-polypeptide-gip-and-gip-receptor-gipr-genes-an-association-analysis-of-polymorphisms-and-bone-in-young-and-elderly-women
#9
Gaurav Garg, Fiona E McGuigan, Jitender Kumar, Holger Luthman, Valeriya Lyssenko, Kristina Akesson
INTRODUCTION: The gastro-intestinal hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-induced insulin secretion, with bone anabolic effects through GIP receptor (GIPR) in animal models. We explore its potential in humans by analyzing association between polymorphisms (SNPs) in the GIP and GIPR genes with bone phenotypes in young and elderly women. METHODS: Association between GIP (rs2291725) and GIPR (rs10423928) and BMD, bone mineral content (BMC), bone microarchitecture, fracture and body composition was analyzed in the OPRA (75y, n = 1044) and PEAK-25 (25y; n = 1061) cohorts and serum-GIP in OPRA...
June 2016: Bone Reports
https://www.readbyqxmd.com/read/28326338/predictors-of-teriparatide-treatment-failure-in-patients-with-low-bone-mass
#10
Tarig Elraiyah, Adil H Ahmed, Zhen Wang, Joshua N Farr, Mohammad H Murad, Matthew T Drake
INTRODUCTION: While teriparatide is the only skeletal anabolic agent approved in the United States, treatment failure is a major concern which complicates its clinical utility. We sought to identify factors that predict response failure in patients with low bone mass. METHOD: We performed a retrospective study of adults with osteopenia or osteoporosis (T-scores < - 1.0 and - 2.5 SD below normal, respectively, at the total hip or lumbar spine) treated with teriparatide at the Mayo Clinic (Rochester, Minnesota) between November 2002-December 2012...
June 2016: Bone Reports
https://www.readbyqxmd.com/read/28323845/insulin-and-bone-health-in-young-adults-the-mediator-role-of-lean-mass
#11
Ana Torres-Costoso, Diana P Pozuelo-Carrascosa, Celia Álvarez-Bueno, Asunción Ferri-Morales, Jose Miota Ibarra, Blanca Notario-Pacheco, Vicente Martínez-Vizcaíno
BACKGROUND: The positive relationship between lean mass (LM) and bone health is well known, but a positive association between insulin and LM has also been described. Insulin has some anabolic properties on bone through the stimulation of osteoblast differentiation, yet the role of LM as a confounder or mediator in this relationship remains uncertain. OBJECTIVE: To examine whether the association between insulin levels and bone health is mediated by LM. METHODS: A cross-sectional study was conducted at the Castilla La Mancha University (Spain) involving 466 young adults (113 young men; 19...
2017: PloS One
https://www.readbyqxmd.com/read/28323145/increased-cortical-porosity-is-associated-with-daily-not-weekly-administration-of-equivalent-doses-of-teriparatide
#12
Roger Zebaze, Ryoko Takao-Kawabata, Yu Peng, Ali Ghasem Zadeh, Kyoko Hirano, Hiroshi Yamane, Aya Takakura, Yukihiro Isogai, Toshinori Ishizuya, Ego Seeman
INTRODUCTION: The pharmacokinetic profile of parathyroid hormone (PTH) determines its effects on bone resorption and formation. When administered intermittently, anabolic effects are favored in comparison with the continuous treatment. Among the intermittent treatment regimens, lower frequency of administration may have a lower effect on bone remodeling. We therefore hypothesized that weekly administration of teriparatide will produce less increase in intracortical remodeling and porosity than reported using daily treatment...
March 16, 2017: Bone
https://www.readbyqxmd.com/read/28321651/effects-of-strontium-ranelate-treatment-on-osteoblasts-cultivated-onto-scaffolds-of-trabeculae-bovine-bone
#13
Gerluza Aparecida Borges Silva, Bruno Machado Bertassoli, Cristiane Aparecida Sousa, Juliano Douglas Albergaria, Rayan Silva de Paula, Erika Cristina Jorge
Blocks of Bovine bone have shown promising results as implantable scaffolds to promote bone regeneration. Strontium ranelate (SrR) is both an antiresorptive and an anabolic drug that has been indicated for oral administration to treat osteoporosis. Few studies, however, have investigated the local effects of SrR and its use in association with biomaterials thus far. In this work, we investigated SrR effects in cultures of primary osteoblasts (PO, from Wistar rats calvaria) and immortalized osteoblasts (IO, from MC3T3-E1 cell line) cultivated as a monolayer or in association with scaffolds of bovine bone in mineralized (MBB) and demineralized (DBB) forms...
March 20, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28318687/protein-intake-distribution-pattern-does-not-affect-anabolic-response-lean-body-mass-muscle-strength-or-function-over-8-weeks-in-older-adults-a-randomized-controlled-trial
#14
Il-Young Kim, Scott Schutzler, Amy M Schrader, Horace J Spencer, Gohar Azhar, Robert R Wolfe, Arny A Ferrando
BACKGROUND & AIMS: In our recent acute metabolic study, we found no differences in the anabolic response to differing patterns of dietary protein intake. To confirm this in a chronic study, we investigated the effects of protein distribution pattern on functional outcomes and protein kinetics in older adults over 8 weeks. METHODS: To determine chronic effects of protein intake pattern at 1.1 g protein/kg/day in mixed meals on lean body mass (LBM), functional outcomes, whole body protein kinetics and muscle protein fractional synthesis rate (MPS) over 8-week respective dietary intervention, fourteen older subjects were randomly divided into either EVEN or UNVEN group...
March 3, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28318324/subchondral-bone-response-to-injected-adipose-derived-stromal-cells-for-treating-osteoarthritis-using-an-experimental-rabbit-model
#15
A Parrilli, G Giavaresi, A Ferrari, F Salamanna, G Desando, B Grigolo, L Martini, M Fini
Although articular cartilage is the target of osteoarthritis (OA), its deterioration is not always clearly associated with patient symptoms. Because a functional interaction between cartilage and bone is crucial, the pathophysiology of OA and its treatment strategy must focus also on subchondral bone. We investigated whether adipose-derived stromal cells (ASCs) injected into a joint at two different concentrations could prevent subchondral bone damage after the onset of mild OA in a rabbit model. We measured both volumetric and densitometric aspects of bone remodeling...
March 20, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28316377/comparative-expression-analyses-of-pro-versus-anti-inflammatory-mediators-within-synovium-of-patients-with-joint-trauma-osteoarthritis-and-rheumatoid-arthritis
#16
Mohammed A Al-Madol, Mohammed Shaqura, Thilo John, Rudolf Likar, Reham Said Ebied, Michael Schäfer, Shaaban A Mousa
Synovial injury and healing are complex processes including catabolic effects by proinflammatory cytokines and anabolic processes by anti-inflammatory mediators. Here we examined the expression of pro- versus anti-inflammatory mediators in synovium of patients with diagnostic arthroscopy (control), joint trauma (JT), osteoarthritis (OA), and rheumatoid arthritis (RA). Synovial samples from these patients were subjected to RT-PCR and double immunofluorescence confocal microscopy of pro- and anti-inflammatory mediators as well as immune cell markers...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28314754/kdm6b-regulates-cartilage-development-and-homeostasis-through-anabolic-metabolism
#17
Jun Dai, Dongsheng Yu, Yafei Wang, Yishan Chen, Heng Sun, Xiaolei Zhang, Shouan Zhu, Zongyou Pan, Boon Chin Heng, Shufang Zhang, Hongwei Ouyang
OBJECTIVES: Epigenetic mechanisms have been reported to play key roles in chondrogenesis and osteoarthritis (OA) development. Here, we sought to identify specific histone demethylases that are involved and delineate the underlying mechanisms. METHODS: We screened the expression of 17 distinct histone demethylases by quantitative real time PCR (qRT-PCR) during chondrogenic differentiation of C3H10T1/2 cells. The role of Kdm6b in cartilage development was then analysed with transgenic Col2a1-CreER(T2);Kdm6b(f/f) ...
March 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28314523/detection-of-anabolic-and-androgenic-steroids-and-or-their-esters-in-horse-hair-using-ultra-high-performance-liquid-chromatography-high-resolution-mass-spectrometry
#18
Karen Y Kwok, Timmy L S Choi, Wai Him Kwok, Jenny K Y Wong, Terence S M Wan
Anabolic and androgenic steroids (AASs) are a class of prohibited substances banned in horseracing at all times. The common approach for controlling the misuse of AASs in equine sports is by detecting the presence of AASs and/or their metabolites in urine and blood samples using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). This approach, however, often falls short as the duration of effect for many AASs are longer than their detection time in both urine and blood...
March 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28314478/osteoinductive-effects-of-glyceollins-on-adult-mesenchymal-stromal-stem-cells-from-adipose-tissue-and-bone-marrow
#19
Marjorie E Bateman, Amy L Strong, Ryan S Hunter, Melyssa R Bratton, Rajesh Komati, Jayalakshmi Sridhar, Kevin E Riley, Guangdi Wang, Daniel J Hayes, Stephen M Boue, Matthew E Burow, Bruce A Bunnell
BACKGROUND: While current therapies for osteoporosis focus on reducing bone resorption, the development of therapies to regenerate bone may also be beneficial. Promising anabolic therapy candidates include phytoestrogens, such as daidzein, which effectively induce osteogenesis of adipose-derived stromal cells (ASCs) and bone marrow stromal cells (BMSCs). PURPOSE: To investigate the effects of glyceollins, structural derivatives of daidzein, on osteogenesis of ASCs and BMSCs...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28303595/a-single-intra-articular-injection-of-fluvastatin-plga-microspheres-reduces-cartilage-degradation-in-rabbits-with-experimental-osteoarthritis
#20
Norio Goto, Ken Okazaki, Yukio Akasaki, Kohei Ishihara, Koji Murakami, Kiyoshi Koyano, Yasunori Ayukawa, Noriyuki Yasunami, Tomohiro Masuzaki, Yasuharu Nakashima
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3- methylglutaryl-coenzyme A (HMG-CoA) reductase, a rate-limiting enzyme of the mevalonate pathway. The anti-inflammatory effect of statins has been reported in recent years. The present study investigated therapeutic effects of the local administration of statin in osteoarthritis (OA). We assessed clinically used statins and selected fluvastatin for further experimentation, as it showed potent anabolic and anti-catabolic effects on human OA chondrocytes...
March 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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