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Prenatal exposure

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https://www.readbyqxmd.com/read/29149272/use-of-paracetamol-ibuprofen-or-aspirin-in-pregnancy-and-risk-of-cerebral-palsy-in-the-child
#1
Tanja Gram Petersen, Zeyan Liew, Anne-Marie Nybo Andersen, Guro L Andersen, Per Kragh Andersen, Torben Martinussen, Jørn Olsen, Cristina Rebordosa, Mette Christophersen Tollånes, Peter Uldall, Allen J Wilcox, Katrine Strandberg-Larsen
Background: It has been debated whether mild analgesics, mainly paracetamol, adversely affect aspects of neurodevelopment. We examined whether mother's use of paracetamol, aspirin or ibuprofen in pregnancy is associated with increased risk of cerebral palsy (CP) in the child. Method: We included 185 617 mother-child pairs from the Danish National Birth Cohort and the Norwegian Mother and Child Cohort Study. We created harmonized definitions of analgesic use in pregnancy, as well as indications for analgesic use and other potential confounders...
November 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29146047/maternal-immune-activation-delays-excitatory-to-inhibitory-gamma-aminobutyric-acid-switch-in-offspring
#2
Irene Corradini, Elisa Focchi, Marco Rasile, Raffaella Morini, Genni Desiato, Romana Tomasoni, Michela Lizier, Elsa Ghirardini, Riccardo Fesce, Diego Morone, Isabella Barajon, Flavia Antonucci, Davide Pozzi, Michela Matteoli
BACKGROUND: The association between maternal infection and neurodevelopmental defects in progeny is well established, although the biological mechanisms and the pathogenic trajectories involved have not been defined. METHODS: Pregnant dams were injected intraperitoneally at gestational day 9 with polyinosinic:polycytidylic acid. Neuronal development was assessed by means of electrophysiological, optical, and biochemical analyses. RESULTS: Prenatal exposure to polyinosinic:polycytidylic acid causes an imbalanced expression of the Na(+)-K(+)-2Cl(-) cotransporter 1 and the K(+)-Cl(-) cotransporter 2 (KCC2)...
November 14, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29145559/prenatal-alcohol-exposure-and-suspected-hearing-impairment-among-children-a-population-based-retrospective-cohort-study
#3
Satomi Yoshida, Calistus Wilunda, Takeshi Kimura, Masato Takeuchi, Koji Kawakami
Aims: This study aimed to examine the association between prenatal alcohol exposure and hearing impairment among Japanese children using early childhood health check-up data. Methods: This retrospective cohort study used population-based health check-up data for children who were born between April 2000 and March 2013 in Hofu city, Japan. Logistic regression models were used to evaluate the association between prenatal alcohol exposure and hearing impairment among children at the age of 36 months...
November 14, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29145516/preconceptual-zika-virus-asymptomatic-infection-protects-against-secondary-prenatal-infection
#4
Lucien H Turner, Jeremy M Kinder, Adrienne Wilburn, Rahul J D'Mello, Makayla R Braunlin, Tony T Jiang, Giang Pham, Sing Sing Way
Pregnant women, and their fetal offspring, are uniquely susceptible to Zika virus and other microbial pathogens capable of congenital fetal infection. Unavoidable exposure to Zika virus in endemic areas underscores the need for identifying at-risk individuals, and protecting expecting mothers and their fetal offspring against prenatal infection. Here we show that primary Zika virus asymptomatic infection in mice confers protection against re-infection, and that these protective benefits are maintained during pregnancy...
November 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29145054/associations-between-prenatal-lead-exposure-and-birth-outcomes-modification-by-sex-and-gstm1-gstt1-polymorphism
#5
Dirga Kumar Lamichhane, Jong-Han Leem, Chang-Shin Park, Mina Ha, Eun-Hee Ha, Hwan-Cheol Kim, Ji-Young Lee, Jung Keun Ko, Yangho Kim, Yun-Chul Hong
Maternal lead exposure is associated with poor birth outcomes. However, modifying effects of polymorphism in glutathione S-transferases (GST) gene and infant sex remain unexplored. Our aim was to evaluate whether associations between prenatal lead and birth outcomes differed by maternal GST genes and infant sex. Prospective data of 782 mother-child pairs from Mothers and Children's Environmental Health (MOCEH) study were used. The genotyping of GST-mu 1 (GSTM1) and theta-1 (GSTT1) polymorphisms was carried out using polymerase chain reaction...
November 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29143629/from-erasure-to-opportunity-a-qualitative-study-of-the-experiences-of-transgender-men-around-pregnancy-and-recommendations-for-providers
#6
Alexis Hoffkling, Juno Obedin-Maliver, Jae Sevelius
BACKGROUND: Some transgender men retain their uterus, get pregnant, and give birth. However, societal attitudes about gender have erected barriers to openly being pregnant and giving birth as a transgender man. Little research exists regarding transgender men's reproductive needs. Anecdotal observations suggest that social change and increasing empowerment of transgender men may result in increasing frequency and openness about pregnancy and birth. Specific needs around conception, pregnancy, and newborn care may arise from transphobia, exogenous testosterone exposure, or from having had (or desiring) gender-affirming surgery...
November 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29143398/a-retrospective-cohort-study-of-the-health-of-children-prenatally-exposed-to-methadone-buprenorphine-or-naltrexone-compared-with-non-exposed-control-children
#7
Erin Kelty, Gary Hulse
BACKGROUND AND OBJECTIVES: Little is known about the health of children exposed to opioid pharmacotherapies in utero. This study aims to examine the health of children from birth to 5 years of age, who were exposed to methadone, buprenorphine, or naltrexone with non-exposed children. METHODS: Children were identified by linking the treatment records of women treated with one of the three opioid pharmacotherapies with midwife notifications. Live-born children exposed to methadone (n = 198), buprenorphine (n = 122), naltrexone (n = 67) in utero, and neonates not prenatally exposed to opioids (n = 387) born between 2001 and 2011 in Western Australia were included in the study...
November 16, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29139646/physical-fitness-and-digit-ratio-2d-4d-in-male-students-from-wroc%C3%A5-aw-poland
#8
Slawomir Koziel, Marek Kociuba Mail, Raja Chakraborty, Zofia Ignasiak
There is sex-difference in humans as regards aerobic efficiency, physical strength and endurance and the sex difference is greatly dependent upon differential concentration of testosterone during different phases of growth and development including the intrauterine phase or prenatal growth. Second-to-fourth digit lengths ratio (2D:4D) is an putative indicator of prenatal testosterone exposure. Lower 2D:4D indicates higher prenatal testosterone exposure and vice versa. Males generally have lower 2D:4D than females...
March 2017: Collegium Antropologicum
https://www.readbyqxmd.com/read/29138256/low-neonatal-plasma-n-6-n-3-pufa-ratios-regulate-offspring-adipogenic-potential-and-condition-adult-obesity-resistance
#9
Michael C Rudolph, Matthew R Jackman, David M Presby, Julie A Houck, Patricia G Webb, Ginger C Johnson, Taylor K Soderborg, Becky A de la Houssaye, Ivana V Yang, Jacob E Friedman, Paul S MacLean
Adipose tissue expansion (ATE) progresses rapidly during postnatal life, influenced by both prenatal maternal factors and postnatal developmental cues. The ratio of n-6 relative to n-3 polyunsaturated fatty acids (PUFA) is thought to regulate perinatal adipogenesis, but the cellular mechanisms and long-term effects are not well understood. We lowered the fetal and postnatal n-6/n-3 PUFA ratio exposure in wildtype offspring, under standard maternal dietary fat amounts, to test effects of low n-6/n-3 ratios on offspring adipogenesis and adipogenic potential...
November 14, 2017: Diabetes
https://www.readbyqxmd.com/read/29137973/exposure-to-polybrominated-diphenyl-ethers-pbdes-and-child-behavior-current-findings-and-future-directions
#10
REVIEW
Ann M Vuong, Kimberly Yolton, Kim N Dietrich, Joseph M Braun, Bruce P Lanphear, Aimin Chen
Polybrominated diphenyl ethers (PBDEs) are recognized neurotoxicants, but the extent to which PBDEs influence various domains of behavior in children is not fully understood. As such, we reviewed epidemiologic studies published to date to provide an overview of the current state of knowledge on PBDEs' potential role in behavioral development. We identified 19 epidemiologic studies reporting on associations of prenatal and childhood concentrations of PBDEs with behaviors assessed in children from 1 to 12years, including executive function, attention, externalizing and internalizing behaviors, adaptive skills, and social behaviors/Autism Spectrum Disorder (ASD)...
November 11, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29136116/prenatal-stress-glucocorticoids-and-developmental-programming-of-the-stress-response
#11
Patrick O McGowan, Stephen G Matthews
The early environment has a major impact on the developing embryo, fetus and infant. Parental adversity (maternal and paternal) and glucocorticoid exposure prior to conception and during pregnancy have profound effects on the development and subsequent function of the hypothalamic-pituitary-adrenal (HPA) axis and related behaviours. These effects are species-, sex- and age-specific, and depend on the timing and duration of exposure. The impact of these early exposures can extend across multiple generations, via both the maternal and paternal lineage, and recent studies have begun to determine the mechanisms by which this occurs...
November 10, 2017: Endocrinology
https://www.readbyqxmd.com/read/29133180/exposure-to-perfluoroalkyl-substances-during-pregnancy-and-child-behaviour-at-5-to-9years-of-age
#12
Birgit Bjerre Høyer, Jens Peter Bonde, Sandra Søgaard Tøttenborg, Cecilia Høst Ramlau-Hansen, Christian Lindh, Henning Sloth Pedersen, Gunnar Toft
We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5-9years of age in birth cohorts from Greenland and Ukraine. Pregnancy serum samples (N=1023) were analysed for perfluoroalkyl substances (PFASs) and categorized into tertiles and also used as continuous exposure variables. Problem behaviour and hyperactivity were assessed, using the Strength and Difficulties Questionnaire (SDQ) and categorized as normal/borderline and abnormal...
November 10, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29132937/arsenic-exposure-during-embryonic-development-alters-the-expression-of-the-long-noncoding-rna-growth-arrest-specific-5-gas5-in-a-sex-dependent-manner
#13
Kevin K Caldwell, Alexander Hafez, Elizabeth Solomon, Matthew Cunningham, Andrea M Allan
Our previous studies suggest that prenatal arsenic exposure (50ppb) modifies epigenetic control of the programming of the glucocorticoid receptor (GR) signaling system in the developing mouse brain. These deficits may lead to long-lasting consequences, including deficits in learning and memory, increased depressive-like behaviors, and an altered set-point of GR feedback throughout life. To understand the arsenic-induced changes within the GR system, we assessed the impact of in utero arsenic exposure on the levels of the GR and growth arrest-specific-5 (Gas5), a noncoding RNA, across a key gestational period for GR programming (gestational days, GD 14-18) in mice...
November 10, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29128414/mapping-of-the-prenatal-and-postnatal-methamphetamine-effects-on-d1-like-dopamine-m1-and-m2-muscarinic-receptors-in-rat-central-nervous-system
#14
Vladimir Farar, Paulina Valuskova, Maria Sevcikova, Jaromir Myslivecek, Romana Slamberova
Methamphetamine (MA) is worldwide known drug with high potential for addiction that causes dopamine, noradrenaline and serotonin release. MA is also able to increase acetylcholine levels in adult rodents. The aim of this study was to map changes in D1-like dopamine receptors (DR), M1 and M2 muscarinic receptors (MR), and the total number of MR (M1-M5 MR) in the CNS of rats exposed to MA prenatally and in adulthood. Rat mothers were exposed to MA (5mg/kg s.c.) or saline during the entire gestation period and their male offspring were administered in adulthood with single MA (1mg/kg) or saline injection...
November 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29127935/determinants-of-prenatal-exposure-to-polybrominated-diphenyl-ethers-pbdes-among-urban-minority-infants-born-between-1998-and-2006
#15
Whitney J Cowell, Andreas Sjödin, Richard Jones, Ya Wang, Shuang Wang, Julie B Herbstman
Polybrominated diphenyl ethers (PBDEs) are environmentally persistent chemicals that structurally resemble legacy pollutants, such as polychlorinated biphenyls (PCBs). PBDEs were added to consumer products for over 30 years, before being phased out due to evidence of toxicity. We examined temporal changes in prenatal exposure to PBDEs, as well as other sources of variation. We measured PBDEs in umbilical cord plasma from 327 minority infants born in New York City between 1998 and 2006. We used linear regression to examine changes in concentrations over time and in relation to lifestyle characteristics collected during pregnancy...
November 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29127805/prenatal-contribution-of-2-2-4-4-tetrabromodiphenyl-ether-bde-47-to-total-body-burden-in-young-children
#16
Mi-Yeon Shin, Sunmi Kim, Sunggyu Lee, Hai-Joong Kim, Jeong Jae Lee, Gyuyeon Choi, Sooran Choi, Sungjoo Kim, Su Young Kim, Jeongim Park, Hyo-Bang Moon, Kyungho Choi, Sungkyoon Kim
Many scientists made estimates of the body burden of PBDEs from breastmilk and house dust. Interestingly, they have not included the prenatal contribution to the body burden in young children after birth. In order to address how the prenatal contribution is important in the risk assessment of PBDEs in infants up to five years old, we used the median measurements of BDE-47 as a model chemical in 108 neonates in Korea, and made simulations of its disposition out of body from birth to five years. During the simulation periods, the environmental exposure was considered for house dust, babyfood, breastmilk consumption, etc...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29127374/prediction-of-human-prenatal-exposure-to-bisphenol-a-and-bisphenol-a-glucuronide-from-an-ovine-semi-physiological-toxicokinetic-model
#17
Glenn Gauderat, Nicole Picard-Hagen, Pierre-Louis Toutain, Rémi Servien, Catherine Viguié, Sylvie Puel, Marlène Z Lacroix, Tanguy Corbel, Alain Bousquet-Melou, Véronique Gayrard
Bisphenol A (BPA) risk assessment is hampered by the difficulty of determining the extent of internal exposure in the human fetus and uncertainties regarding BPA toxicokinetics (TK) in the maternal-fetal unit. A feto-maternal TK model describing BPA and BPA glucuronide (BPAG) disposition in sheep was humanized, using human TK data obtained after d6-BPA administration on a cookie, to predict BPA and BPAG kinetics in the human mother-fetus unit. Validation of the model predictions included the assessed dose proportionality of BPA and BPAG disposition and the similarity between the simulated and measured time courses of BPA and BPAG in fetal rhesus monkeys after BPA maternal dosing...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126190/early-life-exposure-to-china-s-1959-61-famine-and-midlife-cognition
#18
Hongwei Xu, Zhenmei Zhang, Lydia Li, Jinyu Liu
Background: Existing studies of the 1944-45 Dutch famine found little evidence of the association between early life malnutrition and midlife cognition. Methods: Among 2446 rural participants born between 1958 and 1963 in the China Health and Retirement Longitudinal Study, we examined effects of exposure to China's 1959-61 Great Leap Forward famine during prenatal and early postnatal life, on four cognitive measures in 2011 (baseline) and changes in cognition between 2011 and 2013 (first follow-up)...
November 7, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29125320/prenatal-famine-exposure-and-mental-health-in-later-midlife
#19
Thijs van den Broek, Maria Fleischmann
OBJECTIVES: Maternal malnutrition during pregnancy may have long-lasting effects on offspring's mental health. We investigate the effect of prenatal exposure to the Dutch famine (mid November 1944 to late April 1945) on mental health in later mid-life. METHODS: Data are from the Netherlands Kinship Panel Study (n = 642). We use difference-in-difference analyses to compare mental health in later midlife (measured with the MHI-5 index) across three cohorts ('pre-famine cohort', 'famine cohort', 'post-famine cohort') and across two regions (famine affected cities vs...
November 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29124997/perinatal-exposure-to-environmental-tobacco-smoke-is-associated-with-changes-in-dna-methylation-that-precede-the-adult-onset-of-lung-disease-in-a-mouse-model
#20
Elizabeth Cole, Traci A Brown, Kent E Pinkerton, Britten Postma, Keegan Malany, Mihi Yang, Yang Jee Kim, Raymond F Hamilton, Andrij Holian, Yoon Hee Cho
Prenatal and early-life environmental tobacco smoke (ETS) exposure can induce epigenetic alterations associated with inflammation and respiratory disease. The objective of this study was to address the long-term epigenetic consequences of perinatal ETS exposure on latent respiratory disease risk, which are still largely unknown. C57BL/6 mice were exposed to prenatal and early-life ETS; offspring lung pathology, global DNA, and gene-specific methylation were measured at two adult ages. Significant alterations in global DNA methylation and promoter methylation of IFN-γ and Thy-1 were found in ETS-exposed offspring at 10-12 and 20 weeks of age...
August 2017: Inhalation Toxicology
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