keyword
https://read.qxmd.com/read/38546836/review-myogenic-and-muscle-toxicity-targets-of-environmental-methylmercury-exposure
#1
REVIEW
Lok Ming Tam, Matthew D Rand
A number of environmental toxicants are noted for their activity that leads to declined motor function. However, the role of muscle as a proximal toxicity target organ for environmental agents has received considerably less attention than the toxicity targets in the nervous system. Nonetheless, the effects of conventional neurotoxicants on processes of myogenesis and muscle maintenance are beginning to resolve a concerted role of muscle as a susceptible toxicity target. A large body of evidence from epidemiological, animal, and in vitro studies has established that methylmercury (MeHg) is a potent developmental toxicant, with the nervous system being a preferred target...
March 28, 2024: Archives of Toxicology
https://read.qxmd.com/read/38544847/perceptions-of-perinatal-alcohol-use-and-treatment-needs-in-cape-town-south-africa-a-qualitative-study
#2
JOURNAL ARTICLE
Petal Petersen Williams, Lesley-Ann Erasmus-Claassen, Shantae Taylor, Felicia A Browne, Wendee M Wechsberg, Bronwyn Myers, Charles D H Parry, Yukiko Washio
BACKGROUND: South Africa has one of the world's highest rates of foetal alcohol spectrum disorders (FASD). Recent evidence also showed that alcohol use during lactation significantly compromises child development in children exposed to alcohol through breastfeeding, independent of prenatal alcohol exposure. This study explored perceptions of perinatal alcohol use and treatment needs in Cape Town, South Africa, to inform the development of an intervention to encourage alcohol abstinence during pregnancy and breastfeeding...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38544793/evaluation-of-prenatal-calabash-chalk-geophagy-on-the-developing-brain-of-wistar-rats
#3
JOURNAL ARTICLE
Moses B Ekong, Anna Andrioli, Imaobong E Israel, Edemeka I Ifot, Samuel E Dickson, Ilaria Scambi, Paolo F Fabene, Giuseppe Bertini, Marina Bentivoglio
Calabash chalk (CaC) is an aluminium silicate hydroxide compound with heavy metal constituents, making it a potential neurotoxicant. Pregnant women often consume CaC as an antiemetic, which may interfere with the normal development of the foetal brain. Here, we evaluated the effects of CaC administration in pregnant rats on the brain of the offspring. Wistar rat dams were assigned to one of three groups: control, 200 mg/kg and 800 mg/kg of a CaC suspension. Administrations lasted 14 days (gestation days 7-20)...
June 2024: IBRO neuroscience reports
https://read.qxmd.com/read/38544727/racial-and-ethnic-disparities-in-psychological-care-for-individuals-with-fasd-a-dis-ability-studies-and-critical-race-theory-perspective-toward-improving-prevention-assessment-diagnosis-and-intervention
#4
JOURNAL ARTICLE
Madeline N Rockhold, Blake A Gimbel, Alesia A Richardson, Carson Kautz-Turnbull, Emily L Speybroeck, Erik de Water, Julianne Myers, Emily Hargrove, Maggie May, Samia S Abdi, Christie L M Petrenko
Fetal alcohol spectrum disorders (FASD) are among the most common neurodevelopmental disorders and substantially impact public health. FASD can affect people of all races and ethnicities; however, there are important racial and ethnic disparities in alcohol-exposed pregnancy prevention, assessment and diagnosis of FASD, and interventions to support individuals with FASD and their families. In this article we use the Dis/Ability Studies and Critical Race Theory (Dis/Crit) framework to structure the exploration of disparities and possible solutions within these three areas (prevention, diagnosis, intervention)...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38543269/forecasting-fetal-buprenorphine-exposure-through-maternal-fetal-physiologically-based-pharmacokinetic-modeling
#5
JOURNAL ARTICLE
Matthijs W van Hoogdalem, Ryota Tanaka, Khaled Abduljalil, Trevor N Johnson, Scott L Wexelblatt, Henry T Akinbi, Alexander A Vinks, Tomoyuki Mizuno
Buprenorphine readily crosses the placenta, and with greater prenatal exposure, neonatal opioid withdrawal syndrome (NOWS) likely grows more severe. Current dosing strategies can be further improved by tailoring doses to expected NOWS severity. To allow the conceptualization of fetal buprenorphine exposure, a maternal-fetal physiologically based pharmacokinetic (PBPK) model for sublingual buprenorphine was developed using Simcyp (v21.0). Buprenorphine transplacental passage was predicted from its physicochemical properties...
March 8, 2024: Pharmaceutics
https://read.qxmd.com/read/38542255/environmental-pollution-and-risk-of-childhood-cancer-a-scoping-review-of-evidence-from-the-last-decade
#6
REVIEW
María Del Pilar Navarrete-Meneses, Consuelo Salas-Labadía, Fernando Gómez-Chávez, Patricia Pérez-Vera
The long-term effects of environmental pollution have been of concern as several pollutants are carcinogenic, potentially inducing a variety of cancers, including childhood cancer, which is a leading cause of death around the world and, thus, is a public health issue. The present scoping review aimed to update and summarize the available literature to detect specific environmental pollutants and their association with certain types of childhood cancer. Studies published from 2013 to 2023 regarding environmental pollution and childhood cancer were retrieved from the PubMed database...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541201/environmental-exposure-to-pesticides-and-the-risk-of-child-neurodevelopmental-disorders
#7
JOURNAL ARTICLE
Rocio Parrón-Carrillo, Bruno José Nievas-Soriano, Tesifón Parrón-Carreño, David Lozano-Paniagua, Rubén Trigueros
Background and Objectives : Neurodevelopment is a fragile brain process necessary for learning from the beginning of childhood to adulthood. During the procedure, several risks could affect it, including environmental factors such as neurotoxic chemicals or environmental pollutants and, within them, exposure to pesticides. Materials and Methods : This ecological descriptive study attempted to assess the association between environmental exposure to pesticides and neurodevelopmental disorders. This study was conducted on 4830 children diagnosed for 11 years in a total population of 119,897 children in three areas: high, medium, and low greenhouse concentrations...
March 13, 2024: Medicina
https://read.qxmd.com/read/38540789/dissecting-the-long-term-effect-of-stress-early-in-life-on-fkbp5-the-role-of-mir-20b-5p-and-mir-29c-3p
#8
JOURNAL ARTICLE
Nadia Cattane, Maria Grazia Di Benedetto, Ilari D'Aprile, Marco Andrea Riva, Annamaria Cattaneo
Exposure to early-life stress (ELS) has been related to an increased susceptibility to psychiatric disorders later in life. Although the molecular mechanisms underlying this association are still under investigation, glucocorticoid signaling has been proposed to be a key mediator. Here, we used two preclinical models, the prenatal stress (PNS) animal model and an in vitro model of hippocampal progenitor cells, to assess the long-term effect of ELS on FKBP5 , NR3C1 , NR3C2 , and FoxO1 , four stress-responsive genes involved in the effects of glucocorticoids...
March 19, 2024: Biomolecules
https://read.qxmd.com/read/38540110/novel-interventions-on-comorbidities-in-patients-with-fetal-alcohol-spectrum-disorder-fasd-an-integrative-review
#9
REVIEW
Vicente Andreu-Fernández, Nunzia La Maida, Maribel Marquina, Afrouz Mirahi, Oscar García-Algar, Simona Pichini, Adele Minutillo
Prenatal exposure to alcohol can cause Fetal Alcohol Spectrum Disorders (FASDs) after birth, encompassing a spectrum of physical, cognitive, and behavioral abnormalities. FASD represents a severe non-genetic disability avoidable through alcohol abstinence during pregnancy and when planning it. Clinical severity depends on alcohol impact, symptomatology, and resulting disabilities. FASD is a permanent disability with no recognized specific medical care. Conversely, secondary FASD-related disabilities can be symptomatically treated...
February 22, 2024: Biomedicines
https://read.qxmd.com/read/38539336/associations-among-maternal-trauma-history-postnatal-maternal-sensitivity-and-infant-temperament
#10
JOURNAL ARTICLE
Jennifer Lynn Hambleton, Nicki Lynn Aubuchon-Endsley, Jasmin Kurien
Women are at increased risk of trauma exposure and of experiencing prolonged posttraumatic stress. Maternal trauma exposure and associated impairment may adversely impact mother-infant interaction quality, which may in turn be associated with infant temperament difficulties. More research is needed to identify which maternal trauma predictors are most robustly related to infant temperament outcomes. The present study aimed to address this gap by examining maternal sensitivity as a mediator of relations between maternal trauma and infant temperament in a longitudinal study of a rural cohort of mother-infant dyads...
March 2, 2024: Children
https://read.qxmd.com/read/38539304/prenatal-alcohol-exposure-and-metabolic-disorders-in-pediatrics-the-role-of-the-oxidative-stress-a-review-of-the-literature
#11
REVIEW
Martina Derme, Martina Briante, Mauro Ceccanti, Giuseppe Giannini, Mario Vitali, Marisa Patrizia Messina, Maria Grazia Piccioni, Alessandro Mattia, Simona Nicotera, Alba Crognale
Prenatal alcohol exposure is responsible for increasing chronic disease risk in later life, including obesity and metabolic syndrome. Alcohol drinking may compromise endogenous antioxidant capacity, causing an increase in free radicals and reactive oxygen species in the newborn. Excessive reactive oxygen species could attack the cellular proteins, lipids, and nucleic acids, leading to cellular dysfunction. Moreover, oxidative stress could play a crucial role in the altered synthesis and release of neurotrophins and progressive mitochondrial modifications with uncontrolled apoptosis...
February 21, 2024: Children
https://read.qxmd.com/read/38539033/a-comparison-of-two-statewide-datasets-to-understand-population-prevalence-of-substance-use-in-pregnancy-findings-and-considerations-for-policy-research
#12
JOURNAL ARTICLE
Margaret Lloyd Sieger, Jennifer C Morin, Lisa M Budris, Melissa Sienna, Sharon Ostfeld-Johns, Lou Hart, Christopher Morosky
Mental health conditions including substance use disorder are the leading cause of pregnancy-related deaths in the U.S. Unfortunately, fears of child protective services' involvement interfere with maternal self-disclosure of substance use in pregnancy. Seeking to identify more mothers with substance use disorder in pregnancy or at delivery, and responsive to changes to the federal Child Abuse Prevention and Treatment Act (CAPTA), Connecticut requires hospital personnel to submit a deidentified notification to CPS for all newborns with prenatal substance exposure...
March 27, 2024: Maternal and Child Health Journal
https://read.qxmd.com/read/38538856/low-to-moderate-prenatal-alcohol-exposure-and-neurodevelopment-in-a-prospective-cohort-of-early-school-aged-children
#13
JOURNAL ARTICLE
Evelyne Muggli, Jane Halliday, Stephen Hearps, Thi-Nhu-Ngoc Nguyen, Anthony Penington, Deanne K Thompson, Alicia Spittle, Della A Forster, Sharon Lewis, Elizabeth J Elliott, Peter J Anderson
Evidence is strong for adverse fetal effects of high level or chronic prenatal alcohol exposure (PAE), but many pregnant women continue to drink at lower levels. The 'Asking Questions about Alcohol in pregnancy' prospective cohort aimed to determine the neurodevelopmental consequences at 6-8 years of age of low to moderate PAE. 1570 women from seven public antenatal clinics in Melbourne, Australia, provided information on frequency and quantity of alcohol use, and obstetric, lifestyle and socio-environmental confounders at four gestation timepoints...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38537691/prenatal-exposure-to-acid-suppressor-medications-and-development-of-ductus-arteriosus-in-term-newborn
#14
JOURNAL ARTICLE
Ella Segal, Daniella Landau, Lior Hassan, Adir Israeli, Rafael Gorodischer
OBJECTIVE: The ductus arteriosus normally closes after birth. Histamine2 Receptor Antagonist (H2RA) has been associated with patent ductus arteriosus (PDA). We aimed to study the characteristics of term infants with PDA and their possible association with prenatal exposure to antacids - Proton Pump Inhibitors (PPI) and H2RA. STUDY DESIGN: Population-based matched case-control study of mothers registered at "Clalit" Health Maintenance Organization (HMO) and their infants born at "Soroka" University Medical Center (SUMC) between 2001-2018...
March 27, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38533642/increased-risk-of-gestational-hypertension-by-periconceptional-exposure-to-ambient-air-pollution-and-effect-modification-by-prenatal-depression
#15
JOURNAL ARTICLE
Zhongzheng Niu, Rima Habre, Tingyu Yang, Xinci Chen, Mario Vigil, Karina Barragan, Fred Lurmann, Nathan R Pavlovic, Brendan H Grubbs, Claudia M Toledo-Corral, Jill Johnston, Genevieve F Dunton, Deborah Lerner, Nathana Lurvey, Laila Al-Marayati, Sandrah P Eckel, Carrie V Breton, Theresa M Bastain, Shohreh F Farzan
BACKGROUND: Air pollution has been associated with gestational hypertension (GH) and preeclampsia, but susceptible windows of exposure and potential vulnerability by comorbidities, such as prenatal depression, remain unclear. METHODS: We ascertained GH and preeclampsia cases in a prospective pregnancy cohort in Los Angeles, CA. Daily levels of ambient particles (with a diameter of ≤10 μm [PM10 ] or ≤2.5 μm [PM2.5 ]), nitrogen dioxide, and ozone were averaged for each week from 12 weeks preconception to 20 gestational weeks...
March 27, 2024: Hypertension
https://read.qxmd.com/read/38532648/unraveling-hypothalamus-pituitary-dysregulation-hypergonadotropism-in-f-1-progeny-due-to-prenatal-exposure-to-hexavalent-chromium
#16
JOURNAL ARTICLE
Ajit Kumar Navin, Mariajoseph Michael Aruldhas, Kathiresh Kumar Mani, Shobana Navaneethabalakrishnan, Sankar Venkatachalam, Sakhila K Banu
The endocrine disruptor hexavalent chromium [Cr(VI)] is a proven reproductive toxicant. We recently demonstrated that prenatal Cr(VI) exposure causes testicular resistance to gonadotropins, resulting in hypergonadotropic hypoandrogenism in F1 rats. However, the mechanism driving hypergonadotropism in F1 rats exposed to Cr(VI) prenatally remains an enigma. Therefore, we hypothesized that 'Prenatal Cr(VI) exposure may disrupt steroid hormones-mediated negative feedback regulation of the hypothalamic GnRH, and its receptor in the pituitary of F1 rats, leading to hypergonadotropism...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38532124/the-joint-effects-of-prenatal-exposure-to-pm-2-5-constituents-and-reduced-fetal-growth-on-children-s-accelerated-growth-in-the-first-3-years-a-birth-cohort-study
#17
JOURNAL ARTICLE
Shuang Zhou, Tiantian Li, Na Han, Kai Zhang, Gongbo Chen, Yi Zhang, Qin Li, Yuelong Ji, Jue Liu, Hui Wang, Jianlin Hu, Ting Liu, Hein Raat, Yuming Guo, Haijun Wang
BACKGROUND: Prenatal fine particulate matter (PM2.5 ) constituents exposure and reduced fetal growth may be risk factors for accelerated growth in early childhood, an important indicator for lifelong health. OBJECTIVE: The study investigated whether the joint effects are present between PM2.5 constituents and reduced fetal growth. METHODS: The study was embedded in a birth cohort in China, including 5424 mother-child pairs. Prenatal PM2.5 and its constituents' [organic carbon (OC), elementary carbon (EC), ammonium (NH4 + ), nitrate (NO3 - ), and sulfate (SO4 2- )] concentrations were estimated based on maternal residential addresses...
March 26, 2024: Journal of Exposure Science & Environmental Epidemiology
https://read.qxmd.com/read/38531505/residential-greenness-during-pregnancy-and-early-life-and-development-of-asthma-up-to-27-years-of-age-the-espoo-cohort-study
#18
JOURNAL ARTICLE
Aino K Rantala, Inês Paciência, Harri Antikainen, Jan Hjort, Timo T Hugg, Maritta S Jaakkola, Jouni J K Jaakkola
Previous studies have suggested that living close to green spaces has protective health effects, but potential effects on asthma are contradictory. We investigated the association between the amount of greenness in the residential area during pregnancy and early life and development of asthma in the first 27 years of life. The study population included all 2568 members of the Espoo Cohort Study, Finland. We calculated individual-level exposure to green space measured as cumulative Normalized Difference Vegetation Index (cumNDVI in unit-months) within 300 m of the participant's residence during pregnancy and the first two years of life in both spring and summer seasons...
March 24, 2024: Environmental Research
https://read.qxmd.com/read/38531021/neurodevelopmental-and-functional-outcomes-following-in-utero-exposure-to-antiseizure-medication-a-systematic-review
#19
JOURNAL ARTICLE
Eliza Honybun, Emily Cockle, Charles B Malpas, Terence J O'Brien, Frank J Vajda, Piero Perucca, Genevieve Rayner
BACKGROUND AND OBJECTIVES: To undertake a systematic review of the available literature to examine the relationship between prenatal antiseizure medication (ASM) exposure and adverse postnatal neurodevelopmental outcomes, focusing on social, emotional, behavioral, and adaptive domains of human function, and the frequency of neurodevelopmental and psychiatric disorders in ASM-exposed offspring. METHODS: Electronic searches of MEDLINE, PsychINFO, and EMBASE were conducted and limited to studies published between 1990 and 2023 in English...
April 23, 2024: Neurology
https://read.qxmd.com/read/38529692/prenatal-and-postnatal-exposure-to-antibiotics-and-risk-of-food-allergy-in-the-offspring-a-nationwide-birth-cohort-study-in-south-korea
#20
JOURNAL ARTICLE
Jiyeon Oh, Myeongcheol Lee, Jaeyu Park, Hyeon Jin Kim, Seung Won Lee, Masoud Rahmati, Ai Koyanagi, Lee Smith, Min Seo Kim, Guillermo F López Sánchez, Elena Dragioti, Chanyang Min, Nikolaos G Papadopoulos, Youn Ho Shin, Jae Il Shin, Dong Keon Yon
BACKGROUND: There are only preliminary studies examining the associations of postnatal antibiotic exposure with food allergy in childhood, and the effect of antibiotic exposure in utero has not been resolved. Thus, we aimed to investigate the effect of prenatal and postnatal antibiotic exposure on the risk of food allergy in childhood. METHODS: Using the nationwide birth cohort in South Korea, all 3,163,206 infants (pairing mother; n = 2,322,735) born in South Korea between 2010 and 2017 were included in the analysis...
March 2024: Pediatric Allergy and Immunology
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