Israa Habeeb Naser, Asia Ali Hamza, Ahmed Alhili, Ahmed Naser Faisal, Mohammed Shnain Ali, Noor Abdulaala Kadhim, Muath Suliman, Mohammad Y Alshahrani, Ahmed Alawadi
Atypical chemokine receptor 4 (ACKR4), also known as CCX-CKR, is a member of the chemokine receptor family that lacks typical G protein signaling activity. Instead, ACKR4 functions as a scavenger receptor that can bind and internalize a wide range of chemokines, influencing their availability and activity in the body. ACKR4 is involved in various physiological processes, such as immune cell trafficking and the development of thymus, spleen, and lymph nodes. Moreover, ACKR4 has been implicated in several pathological conditions, including cancer, heart and lung diseases...
April 2024: Cell Biochemistry and Function