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https://www.readbyqxmd.com/read/28345423/systemic-lupus-erythematosus-and-hearing-disorders-literature-review-and-meta-analysis-of-clinical-and-temporal-bone-findings
#1
Arianna Di Stadio, Massimo Ralli
Objective This literature review and meta-analysis was performed to evaluate the correlations among hearing and vestibular clinical symptoms, temporal bone findings, and pathological mechanisms in patients with systemic lupus erythematosus (SLE). Study design Relevant papers in the literature were retrospectively reviewed. Clinical hearing aspects in patients with SLE and relevant temporal bone studies in the same field were analyzed. Methods PubMed and Google Scholar searches were performed using the following keywords: "auto-immune disease," "systemic lupus erythematosus (SLE)," "hearing loss," "temporal bone study," "vertigo," "dizziness," "tinnitus," "ear symptoms," "treatment," "diagnosis," "symptoms," "etiopathogenesis," "Wegener granulomatosis," "Sjogren," "polyarteritis nodosa," "Cogan syndrome," and "granulomatosis...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28282015/relying-on-the-national-mobile-disaster-hospital-as-a-business-continuity-strategy-in-the-aftermath-of-a-tornado-the-louisville-experience
#2
Randy D Kearns, Lew Stringer, James Craig, Regina Godette-Crawford, Paul S Black, David L Andra, James Winslow
On 28th April, 2014, a tornado left much of Louisville, MS and the local hospital, Winston Medical Center, in ruin. In the USA, temporary hospital solutions have been used to augment the mainstream healthcare system since the American Civil War. As memories fade, however, the necessary readiness for a temporary hospital also fades, at times leaving a patchwork of resources either underfunded or abandoned. With the creation of the Hospital Preparedness Program, several temporary hospital solutions were created in various states across the USA...
January 1, 2017: Journal of Business Continuity & Emergency Planning
https://www.readbyqxmd.com/read/28281664/genetic-interactions-and-functional-analyses-of-the-fission-yeast-gsk3-and-amk2-single-and-double-mutants-defective-in-torc1-dependent-processes
#3
Charalampos Rallis, StJohn Townsend, Jürg Bähler
The Target of Rapamycin (TOR) signalling network plays important roles in aging and disease. The AMP-activated protein kinase (AMPK) and the Gsk3 kinase inhibit TOR during stress. We performed genetic interaction screens using synthetic genetic arrays (SGA) with gsk3 and amk2 as query mutants, the latter encoding the regulatory subunit of AMPK. We identified 69 negative and 82 positive common genetic interactors, with functions related to cellular growth and stress. The 120 gsk3-specific negative interactors included genes functioning in translation and ribosomes...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28273485/clinical-factors-of-response-in-patients-with-advanced-ovarian-cancer-participating-in-early-phase-clinical-trials
#4
Angela George, Rebecca Kristeleit, Saeed Rafii, Caroline O Michie, Rebecca Bowen, Vasiliki Michalarea, Tom van Hagen, Mabel Wong, Grigorios Rallis, L Rhoda Molife, Juanita Lopez, Udai Banerji, Susana N Banerjee, Martin E Gore, Johann S de Bono, Stan B Kaye, Timothy A Yap
Drug resistance to conventional anticancer therapies is almost inevitable in patients with advanced ovarian cancer (AOC), limiting their available treatment options. Novel phase I trial therapies within a dedicated drug development unit may represent a viable alternative; however, there is currently little evidence for patient outcomes in such patients. To address this, we undertook a retrospective review of patients with AOC allocated to phase I trials in the Drug Development Unit at Royal Marsden Hospital (RMH) between June 1998 and October 2010...
March 5, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28267726/trump-s-pick-rallies-biosimilar-makers
#5
(no author information available yet)
No abstract text is available yet for this article.
March 7, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28253438/collaboration-among-sectors-to-increase-pulse-consumption
#6
Julianne Curran, Milla McLachlan, Richard Black, Irv Widders, Mark Manary
The United Nations declaration of 2016 as the International Year of Pulses (IYP) provided an unprecedented opportunity to showcase pulses on the global stage for their contribution to affordable nutrition, health, and sustainability. Despite the IYP's successes in stakeholder engagement, continuing to foster and strengthen partnerships and collaborations is necessary to meet the IYP goals of increased pulse production and consumption for human benefit. Shifting consumer behavior to increase pulse consumption emerged during IYP meetings as a shared priority for all stakeholders...
March 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28230665/it-s-time-to-earn-the-public-s-trust
#7
Maureen Shawn Kennedy
As the most trusted profession, will nursing rally to safeguard access to care?
March 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28222847/relying-on-the-national-mobile-disaster-hospital-as-a-business-continuity-strategy-in-the-aftermath-of-a-tornado-the-louisville-experience
#8
Randy D Kearns, Lew Stringer, James Craig, Regina Godette-Crawford, Paul S Black, David L Andra, James Winslow
On 28th April, 2014, a tornado left much of Louisville, MS and the local hospital, Winston Medical Center, in ruin. In the USA, temporary hospital solutions have been used to augment the mainstream healthcare system since the American Civil War. As memories fade, however, the necessary readiness for a temporary hospital also fades, at times leaving a patchwork of resources either underfunded or abandoned. With the creation of the Hospital Preparedness Program, several temporary hospital solutions were created in various states across the USA...
January 1, 2017: Journal of Business Continuity & Emergency Planning
https://www.readbyqxmd.com/read/28210348/game-performance-and-length-of-rally-in-professional-padel-players
#9
Javier Courel-Ibáñez, Bernardino Javier Sánchez-Alcaraz Martínez, Jerónimo Cañas
The purpose of this study was to analyse differences in rally length considering attack effectiveness, a players' location and a game outcome in professional padel players. A total of 1527 rallies from 10 male matches of the 2013 Masters Finals of the World Padel Tour were registered through systematic observation. Data treatment included non-parametric mean comparisons (Mann-Withney and Kruskal-Wallis tests), and association analyses (crosstabs and Chi square analysis). In overall, 40% of unforced errors were made within the first 4 s of the rally, over 50% of points were scored between the 5th and 11th s, and 30% of forced errors occurred after the 11th -s of the rally...
January 1, 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28210345/the-dutch-technical-tactical-tennis-test-d4t-for-talent-identification-and-development-psychometric-characteristics
#10
Nikki Kolman, Barbara Huijgen, Tamara Kramer, Marije Elferink-Gemser, Chris Visscher
This study examined the test-retest reliability, validity and feasibility of the newly developed Dutch Technical-Tactical Tennis Test (D4T). This new test is relevant for talent identification and development in tennis. Thirty-two youth male tennis players (age 13.4 ± 0.5) were classified as elite (n = 15) or sub-elite (n = 17) according to their position on the national youth ranking list under 15 years (cut-off rank 50) in the Netherlands. Games, rallies and different tactical situations (i.e. offensive, neutral and defensive) were simulated with a ball machine...
January 1, 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28210338/influence-of-game-evolution-and-the-phase-of-competition-on-temporal-game-structure-in-high-level-table-tennis-tournaments
#11
Jorge Vieira de Mello Leite, Fabio Augusto Barbieri, Willian Miyagi, Elvis de Souza Malta, Alessandro Moura Zagatto
The aims of this study were: a) to investigate the game temporal structure in high-level table tennis competitions; b) to verify the influence of game evolution in international competitions from 2009 to 2012 (World Table Tennis Championships and the Olympic Games) on game temporal structure; c) to compare game temporal structure according to the phase of competition. Comparisons between the three international tournaments demonstrated that rally duration decreased significantly (p < 0.05) during the analyzed period (2009-2012), while the rest time increased (p < 0...
January 1, 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28204781/differences-in-pain-perception-between-men-and-women-of-reproductive-age-a-laser-evoked-potentials-study
#12
Chryssoula Staikou, Panagiotis Kokotis, Andreas Kyrozis, Demetrios Rallis, George Makrydakis, Dimitra Manoli, Nikolaos Karandreas, Elefterios Stamboulis, Christos Moschovos, Argyro Fassoulaki
No abstract text is available yet for this article.
February 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28202426/integrated-platform-for-home-services-using-new-products-and-services-for-senior-citizens-call-cnav-carsat-2015
#13
Michel Noguès, Daniel Laune, Delphine Paccard, Anne-Laure Coupet, Justine Millot-Keurinck, Narjis Bototo, Marine Bertrand, Jean Bousquet
This project is part of: i) the risks of ageing prevention policy of the French retirement and occupational health insurance agency of Languedoc Roussillon (Carsat-LR) and ii) the European innovation partnership on active and healthy ageing (EIP on AHA). It aims to support senior citizens who live independently and have been identified at risk of frailty on a social or health level. The purpose is to increase legibility as well as technical and financial access to innovations for vulnerable seniors who are remote from the digital era, through a multiservice user-friendly platform...
February 15, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28182523/monitoring-hitting-load-in-tennis-using-inertial-sensors-and-machine-learning
#14
David Whiteside, Olivia Cant, Molly Connolly, Machar Reid
PURPOSE: Quantifying external workload is fundamental to training prescription in sport. In tennis, global positioning data are imprecise and fail to capture hitting loads. The current gold standard (manual notation) is time intensive and often not possible given players' heavy travel schedules. The aim of this study was to develop an automated stroke classification system to help quantify hitting load in tennis. METHODS: 18 athletes wore an inertial measurement unit (IMU) on their wrist during 66 video-recorded training sessions...
February 9, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28168075/metastatic-renal-cell-carcinoma-presenting-as-a-paranasal-sinus-mass-the-importance-of-differential-diagnosis
#15
Massimo Ralli, Giancarlo Altissimi, Rosaria Turchetta, Mario Rigante
Metastases in the paranasal sinuses are rare; renal cell carcinoma is the most common cancer that metastasizes to this region. We present the case of a patient with a 4-month history of a rapidly growing mass of the nasal pyramid following a nasal trauma, associated with spontaneous epistaxis and multiple episodes of hematuria. Cranial CT scan and MRI showed an ethmoid mass extending to the choanal region, the right orbit, and the right frontal sinus with an initial intracranial extension. Patient underwent surgery with a trans-sinusal frontal approach using a bicoronal incision combined with an anterior midfacial degloving; histological exam was compatible with a metastasis of clear cell renal cell carcinoma...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28149371/physiological-responses-and-match-characteristics-in-professional-tennis-players-during-a-one-hour-simulated-tennis-match
#16
Bülent Kilit, Ömer Şenel, Erşan Arslan, Sema Can
The purpose of this study was to investigate the effects of serve and return game situations on physiological responses and match characteristics in professional male tennis players during one hour-long simulated singles tennis matches. Ten internationally ranked tennis players (age 22.2 ± 2.8 years; body height 180.7 ± 4.4 cm; body mass 75.9 ± 8.9 kg) participated in this study. Their physiological responses were measured using two portable analyzers during indoor hard court matches. Ratings of perceived exertion were also determined at the end of the game...
June 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28148488/us-activists-from-both-sides-of-abortion-debate-rally-in-washington
#17
Matt Wilkes
No abstract text is available yet for this article.
February 1, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28130493/mlkl-activation-triggers-nlrp3-mediated-processing-and-release-of-il-1%C3%AE-independently-of-gasdermin-d
#18
Kimberley D Gutierrez, Michael A Davis, Brian P Daniels, Tayla M Olsen, Pooja Ralli-Jain, Stephen W G Tait, Michael Gale, Andrew Oberst
Necroptosis is a form of programmed cell death defined by activation of the kinase receptor interacting protein kinase 3 and its downstream effector, the pseudokinase mixed lineage kinase domain-like (MLKL). Activated MLKL translocates to the cell membrane and disrupts it, leading to loss of cellular ion homeostasis. In this study, we use a system in which this event can be specifically triggered by a small-molecule ligand to show that MLKL activation is sufficient to induce the processing and release of bioactive IL-1β...
March 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28125171/prevalence-of-increased-canine-pancreas-specific-lipase-concentrations-in-young-dogs-with-parvovirus-enteritis
#19
Irida V Kalli, Katerina K Adamama-Moraitou, Michael N Patsika, Dimitra Pardali, Jörg M Steiner, Jan S Suchodolski, George Menexes, Georgia D Brellou, Timoleon S Rallis
BACKGROUND: Pancreatic abnormalities during canine parvovirus (CPV) enteritis have not been studied prospectively. OBJECTIVES: The objective of this study was to evaluate the diagnostic significance of canine serum pancreas-specific lipase (Spec cPL) concentration in dogs with CPV enteritis for the presence of acute pancreatitis (AP). Puppies with naturally occurring CPV enteritis were recruited and prospectively allocated into 2 groups according to normal or increased serum Spec cPL concentration...
January 26, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28117401/transient-structural-variations-have-strong-effects-on-quantitative-traits-and-reproductive-isolation-in-fission-yeast
#20
Daniel C Jeffares, Clemency Jolly, Mimoza Hoti, Doug Speed, Liam Shaw, Charalampos Rallis, Francois Balloux, Christophe Dessimoz, Jürg Bähler, Fritz J Sedlazeck
Large structural variations (SVs) within genomes are more challenging to identify than smaller genetic variants but may substantially contribute to phenotypic diversity and evolution. We analyse the effects of SVs on gene expression, quantitative traits and intrinsic reproductive isolation in the yeast Schizosaccharomyces pombe. We establish a high-quality curated catalogue of SVs in the genomes of a worldwide library of S. pombe strains, including duplications, deletions, inversions and translocations. We show that copy number variants (CNVs) show a variety of genetic signals consistent with rapid turnover...
January 24, 2017: Nature Communications
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