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https://www.readbyqxmd.com/read/28923870/associations-between-voriconazole-therapeutic-drug-monitoring-toxicity-and-outcome-in-liver-transplant-patients-an-observational-study
#1
Zahra Hashemizadeh, Parisa Badiee, Seyed Ali Malekhoseini, Hadi Raeisi Shahraki, Bita Geramizadeh, Hashem Montaseri
The aim of this study was to investigate the variability of voriconazole plasma level and its relationship with clinical outcomes and adverse events, among liver transplant recipients to optimize the efficacy and safety of their treatment. Liver transplant recipients treated with voriconazole were included and voriconazole trough levels were quantified by the validated high-performance liquid chromatography method. Cytochrome P450 genotypes of CYP2C19 were evaluated in allograft liver tissues. A total of 832 voriconazole trough levels from 104 patients were measured...
September 18, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28875449/an-extracorporeal-carbon-dioxide-removal-ecco2r-device-operating-at-hemodialysis-blood-flow-rates
#2
R Garrett Jeffries, Laura Lund, Brian Frankowski, William J Federspiel
BACKGROUND: Extracorporeal carbon dioxide removal (ECCO2R) systems have gained clinical appeal as supplemental therapy in the treatment of acute and chronic respiratory injuries with low tidal volume or non-invasive ventilation. We have developed an ultra-low-flow ECCO2R device (ULFED) capable of operating at blood flows comparable to renal hemodialysis (250 mL/min). Comparable operating conditions allow use of minimally invasive dialysis cannulation strategies with potential for direct integration to existing dialysis circuitry...
September 6, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28862876/quantification-of-cotinine-in-dried-blood-spots-as-a-biomarker-of-exposure-to-tobacco-smoke
#3
Daniel Ladror, Bruce Pitt, William Funk
OBJECTIVE: We present an ultra-sensitive, minimally-invasive method for quantifying cotinine in dried blood spot (DBS) samples as a biomarker of exposure to tobacco smoke that can be collected using a simple heel or finger prick to obtain blood samples. METHODS: Cotinine levels were measured in matched plasma and reconstituted DBS samples from smokers and nonsmokers to evaluate assay parameters. In addition, we applied this new method to finger-prick DBS samples that were collected from infants, children and young adults ages 1-21 to estimate exposure to tobacco smoke...
September 18, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28839475/the-coronal-tooth-fractures-preliminary-evaluation-of-a-three-year-follow-up-of-the-anterior-teeth-direct-fragment-reattachment-technique-without-additional-preparation
#4
Lo Giudice G, Alibrandi A, Lipari F, Lizio A, Lauritano F, Cervino G, Cicciù M
OBJECTIVE: The aim of this research is to describe and to analyse the long-term results and the clinical steps of direct fragment reattachment technique with no additional tooth preparation, used to treat crown fracture. This technique achieves the clinical success, combining satisfactory aesthetic and functional results with a minimally invasive approach. METHODS: The 3 years follow-up included 9 patients (5 males, 4 females) with coronal fracture. In all the cases the fragment was available and intact...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28807248/tumor-model-for-surgical-simulation-to-assess-a-minimally-invasive-endoscopic-approach-for-midcheek-mass-removal
#5
Giovanni Dell' Aversana Orabona, Antonio Romano, Paola Bonavolontà, Vincenzo Abbate, Alfonso Manfuso, Giorgio Iaconetta, Bernhard Hirt, Luigi Califano
INTRODUCTION: The midcheek is considered one of the most important facial area due to its involvement in mimic expression and communication. Pathology of this district is complex due to the variety of soft tissue belonging to the face. We propose a surgical simulation, to assess the feasibility of a new minimally invasive endoscopic approach for midcheek mass removal. TECHNICAL REPORT: This study was performed on four cadavers, at the Anatomy Laboratory of the University of Tubingen...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28753500/laparoscopic-minilaparoscopic-single-port-and-percutaneous-hysterectomy-comparison-of-perioperative-outcomes-of-minimally-invasive-approaches-in-gynecologic-surgery
#6
C Rossitto, S Cianci, S Gueli Alletti, E Perrone, S Pizzacalla, G Scambia
OBJECTIVES: During the last decade endoscopic surgical procedures have been constantly evolving. The latest innovation in ultra-minimally invasive surgery (MIS) is the percutaneous technology (Percuvance™ Percutaneous Surgical System (PSS), Teleflex Inc., USA). We compared surgical outcome of hysterectomy, in a retrospective cohort study using the most recent MIS techniques as single-site (LESS) surgery, 3mm laparoscopy (MiniLPS) and percutaneous system (PSS) with standard laparoscopy (LPS)...
July 19, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28720368/a-critical-review-of-miniaturised-percutaneous-nephrolithotomy-is-smaller-better
#7
REVIEW
Silvia Proietti, Guido Giusti, Mahesh Desai, Arvind P Ganpule
CONTEXT: In an effort to reduce morbidity related to percutaneous nephrolithotomy (PCNL), some investigators have progressively introduced miniaturised approaches. The development of miniaturised nephroscopes facilitated widespread dissemination of these techniques and a significant expansion of the role of PCNL in endourology. OBJECTIVE: To discuss the different techniques comprising modern PCNL and identify the pros and cons of each of them. EVIDENCE ACQUISITION: Data for this review were identified through a search of PubMed, including studies published in the last 20 yr in core clinical journals in English...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28663850/multimodal-evaluation-of-ultra-short-laser-pulses-treatment-for-skin-burn-injuries
#8
Moises Oliveira Dos Santos, Anne Latrive, Pedro Arthur Augusto De Castro, Wagner De Rossi, Telma Maria Tenorio Zorn, Ricardo Elgul Samad, Anderson Zanardi Freitas, Carlos Lenz Cesar, Nilson Dias Vieira Junior, Denise Maria Zezell
Thousands of people die every year from burn injuries. The aim of this study is to evaluate the feasibility of high intensity femtosecond lasers as an auxiliary treatment of skin burns. We used an in vivo animal model and monitored the healing process using 4 different imaging modalities: histology, Optical Coherence Tomography (OCT), Second Harmonic Generation (SHG), and Fourier Transform Infrared (FTIR) spectroscopy. 3 dorsal areas of 20 anesthetized Wistar rats were burned by water vapor exposure and subsequently treated either by classical surgical debridement, by laser ablation, or left without treatment...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28629611/sentinel-lymph-node-mapping-in-minimally-invasive-surgery-role-of-imaging-with-color-segmented-fluorescence-csf
#9
Maite I Lopez Labrousse, Michael Frumovitz, M Guadalupe Patrono, Pedro T Ramirez
OBJECTIVE: Sentinel lymph node mapping, alone or in combination with pelvic lymphadenectomy, is considered a standard approach in staging of patients with cervical or endometrial cancer [1-3]. The goal of this video is to demonstrate the use of indocyanine green (ICG) and color-segmented fluorescence when performing lymphatic mapping in patients with gynecologic malignancies. METHODS: Injection of ICG is performed in two cervical sites using 1mL (0.5mL superficial and deep, respectively) at the 3 and 9 o'clock position...
September 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28595496/reconstruction-of-input-functions-from-a-dynamic-pet-image-with-sequential-administration-of-15-o2-and-formula-see-text-for-noninvasive-and-ultra-rapid-measurement-of-cbf-oef-and-cmro2
#10
Nobuyuki Kudomi, Yukito Maeda, Hiroyuki Yamamoto, Yuka Yamamoto, Tetsuhiro Hatakeyama, Yoshihiro Nishiyama
CBF, OEF, and CMRO2 images can be quantitatively assessed using PET. Their image calculation requires arterial input functions, which require invasive procedure. The aim of the present study was to develop a non-invasive approach with image-derived input functions (IDIFs) using an image from an ultra-rapid O2 and C(15)O2 protocol. Our technique consists of using a formula to express the input using tissue curve with rate constants. For multiple tissue curves, the rate constants were estimated so as to minimize the differences of the inputs using the multiple tissue curves...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28500566/an-update-on-addressing-important-peripheral-nerve-problems-challenges-and-potential-solutions
#11
Wilson Z Ray, Mark A Mahan, Danzhu Guo, Danqing Guo, Michel Kliot
From time to time it is thoughtful and productive to review a medical field and reflect upon what are the major issues that need to be addressed and what is being done to do so. This review article is not meant to be all-inclusive but rather focuses on four evolving areas in the field of peripheral nerve disorders and treatments: (1) nerve surgery under ultrasound guidance using a new ultra-minimally invasive thread technique; (2) evolving magnetic resonance imaging (MRI) and ultrasound imaging techniques that are helping to both diagnose and treat a variety of peripheral nerve problems including entrapment neuropathies, traumatic nerve injuries, and masses arising from nerves; (3) promoting recovery after nerve injury using electrical stimulation; and (4) developing animal models to reproduce a severe nerve injury (neurotmetic grade in continuity) that requires a surgical intervention and repair...
May 12, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28478724/role-of-minimally-invasive-percutaneous-nephrolithotomy-techniques-micro-and-ultra-mini-pcnl-15f-in-the-pediatric-population-a-systematic-review
#12
Patrick Jones, Grace Bennett, Omar M Aboumarzouk, Stephen Griffin, Bhaskar K Somani
INTRODUCTION: Management of pediatric stone disease is challenging, with standard percutaneous nephrolithotomy (PCNL) having a good stone-free rate (SFR), but with associated high complication rates. Miniaturization of this technique has led to the rise of minimally invasive PCNL techniques such as micro (<10F) and ultra-mini (<15F) PCNL procedures. Our objective was to perform a systematic review of the literature to evaluate the success and complication rates of minimally invasive PCNL techniques in the pediatric age group (<18 years)...
June 13, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28351627/non-targeted-lc-ms-based-metabolomics-analysis-of-the-urinary-steroidal-profile
#13
Amelia Palermo, Francesco Botrè, Xavier de la Torre, Nicola Zamboni
The urinary steroidal fraction has been extensively explored as non-invasive alternative to monitor pathological conditions as well as to unveil the illicit intake of pseudo-endogenous anabolic steroids in sport. However, the majority of previous approaches involved the a priori selection of potentially relevant target analytes. Here we describe the non-targeted analysis of the urinary steroidal profiles. The workflow includes minimal sample pretreatment and normalization according to the specific gravity of urine, a 20 min reverse phase ultra-performance liquid chromatographic separation hyphenated to electrospray time-of-flight mass spectrometry...
April 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28325008/feasibility-of-an-ultra-low-power-digital-signal-processor-platform-as-a-basis-for-a-fully-implantable-brain-computer-interface-system
#14
Po T Wang, Keulanna Gandasetiawan, Colin M McCrimmon, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do
A fully implantable brain-computer interface (BCI) can be a practical tool to restore independence to those affected by spinal cord injury. We envision that such a BCI system will invasively acquire brain signals (e.g. electrocorticogram) and translate them into control commands for external prostheses. The feasibility of such a system was tested by implementing its benchtop analogue, centered around a commercial, ultra-low power (ULP) digital signal processor (DSP, TMS320C5517, Texas Instruments). A suite of signal processing and BCI algorithms, including (de)multiplexing, Fast Fourier Transform, power spectral density, principal component analysis, linear discriminant analysis, Bayes rule, and finite state machine was implemented and tested in the DSP...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28247667/-ultraminipercutaneous-nephrolithotripsy-in-treating-kidney-stones
#15
A G Martov, S V Dutov, A S Andronov
INTRODUCTION: Percutaneous nephrolithotripsy (PNL) is the recommended method of surgical treatment of kidney stones of size greater than 2 cm. Trends in the development of modern urology have been steadily toward less traumatic method to treat nephrolithiasis - minimally invasive PNL. The present work aimed to explore of the possibilities of one of the modern variants of minimally invasive PNL - ultra-mini-PNL in treating nephrolithiasis. MATERIALS AND METHODS: The study included 60 patients (mean age 45...
April 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28227510/feasibility-of-an-ultra-low-power-digital-signal-processor-platform-as-a-basis-for-a-fully-implantable-brain-computer-interface-system
#16
Po T Wang, Keulanna Gandasetiawan, Colin M McCrimmon, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, Po T Wang, Keulanna Gandasetiawan, Colin M McCrimmon, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, An H Do, Zoran Nenadic, Colin M McCrimmon, Keulanna Gandasetiawan, Payam Heydari, Alireza Karimi-Bidhendi, Po T Wang, Charles Y Liu
A fully implantable brain-computer interface (BCI) can be a practical tool to restore independence to those affected by spinal cord injury. We envision that such a BCI system will invasively acquire brain signals (e.g. electrocorticogram) and translate them into control commands for external prostheses. The feasibility of such a system was tested by implementing its benchtop analogue, centered around a commercial, ultra-low power (ULP) digital signal processor (DSP, TMS320C5517, Texas Instruments). A suite of signal processing and BCI algorithms, including (de)multiplexing, Fast Fourier Transform, power spectral density, principal component analysis, linear discriminant analysis, Bayes rule, and finite state machine was implemented and tested in the DSP...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28215061/the-innovation-trial-four-year-safety-and-effectiveness-of-the-incraft%C3%A2-aaa-stent-graft-system-for-endovascular-repair
#17
MULTICENTER STUDY
Giovanni Pratesi, Carlo Pratesi, Roberto Chiesa, Gioacchino Coppi, Dierk Scheinert, Jan S Brunkwall, Stefaan van der Meulen, Giovanni Torsello
BACKGROUND: This paper reports the 4-year safety and effectiveness of the INCRAFT® AAA Stent-Graft System (Cordis Corp., Milpitas, CA, USA), an ultra-low-profile device for the treatment of abdominal aortic aneurysms. METHODS: The INNOVATION Trial is the prospective, first-in-human, multicenter trial to evaluate the safety and effectiveness of the INCRAFT® System. Patients underwent annual clinical and computed tomography angiography examination as part of the study protocol...
October 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28207655/internally-randomized-control-trial-of-radiation-exposure-using-ultra-low-radiation-imaging-versus-traditional-c-arm-fluoroscopy-for-patients-undergoing-single-level-minimally-invasive-transforaminal-lumbar-interbody-fusion
#18
RANDOMIZED CONTROLLED TRIAL
Timothy Y Wang, S Harrison Farber, Scott S Perkins, Adam G Back, Sarah A Byrd, Debbie Chi, David Vincent, Isaac O Karikari
STUDY DESIGN: Randomized controlled trial. OBJECTIVE: To compare radiation exposure between ultra-low radiation imaging (ULRI) with image enhancement and standard-dose fluoroscopy for patients undergoing minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). SUMMARY OF BACKGROUND DATA: Although the benefits of MIS are lauded by many, there is a significant amount of radiation exposure to surgeon and operating room personnel...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28197040/re-agrawal-et-al-ultra-mini-percutaneous-nephrolithotomy-a-minimally-invasive-option-for-percutaneous-stone-removal-indian-j-urol-2016-32-132-6
#19
COMMENT
Mohd Nazli Kamarulzaman
No abstract text is available yet for this article.
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28197030/superperc-a-new-technique-in-minimally-invasive-percutaneous-nephrolithotomy
#20
Kaushik Shah, Madhu Sudan Agrawal, Dilip Kumar Mishra
INTRODUCTION: Percutaneous nephrolithotomy (PCNL) has undergone significant changes in recent years in the quest for improving efficacy and reducing morbidity. Newer minimally-invasive modalities of PCNL such as mini-PCNL, ultra-mini PCNL, and micro-PCNL have evolved with advancement in optics and technology. However, with these newer advancements, migration of small fragments produced with laser lithotripsy remains a concern, which may result in incomplete stone clearance. We describe a new technique of PCNL termed "Superperc", that utilizes suction to remove all the fragments and maintain one-way flow...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
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