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https://www.readbyqxmd.com/read/28088212/ultrasensitive-detection-of-oncogenic-human-papillomavirus-in-oropharyngeal-tissue-swabs
#1
Andre Isaac, Morris Kostiuk, Han Zhang, Cameron Lindsay, Fawaz Makki, Daniel A O'Connell, Jeffrey R Harris, David W J Cote, Hadi Seikaly, Vincent L Biron
BACKGROUND: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) caused by oncogenic human papillomavirus (HPV) is rising worldwide. HPV-OPSCC is commonly diagnosed by RT-qPCR of HPV E6 and E7 oncoproteins or by p16 immunohistochemistry (IHC). Droplet digital PCR (ddPCR) has been recently reported as an ultra-sensitive and highly precise method of nucleic acid quantification for biomarker analysis. To validate the use of a minimally invasive assay for detection of oncogenic HPV based on oropharyngeal swabs using ddPCR...
January 14, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28052273/current-status-of-exposed-endoscopic-full-thickness-resection-and-further-development-of-non-exposed-endoscopic-full-thickness-resection
#2
Hirohito Mori, Asadur Rahman, Hideki Kobara, Shintaro Fujihara, Noriko Nishiyama, Maki Ayaki, Tae Matsunaga, Masanori Murakami, Tsumomu Masaki
Endoscopic full-thickness resection (EFTR) is a procedure that makes it possible to access the lesions that are on the wall of the digestive tract via the shortest distance through the mouth. Because of the ultra-minimal invasive nature of the treatment, pure EFTR is a highly promising surgical procedure that allows the radical excision of full-thickness layers of digestive tract tumors using only a flexible endoscope. There are 2 types of EFTR methods: exposed and non-exposed. Considering the risks of contracting infection and intraperitoneal dissemination of tumor cells, non-exposed EFTR is an ideal method...
2017: Digestion
https://www.readbyqxmd.com/read/28028577/percutaneous-ultrasound-guided-carpal-tunnel-release-study-upon-clinical-efficacy-and-safety
#3
David Petrover, Jonathan Silvera, Thierry De Baere, Marie Vigan, Antoine Hakimé
OBJECTIVES: To evaluate the feasibility and 6 months clinical result of sectioning of the transverse carpal ligament (TCL) and median nerve decompression after ultra-minimally invasive, ultrasound-guided percutaneous carpal tunnel release (PCTR) surgery. METHODS: Consecutive patients with carpal tunnel syndrome were enrolled in this descriptive, open-label study. The procedure was performed in the interventional radiology room. Magnetic resonance imaging was performed at baseline and 1 month...
December 27, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27991632/tissue-factor-specific-ultra-bright-serrs-nanostars-for-raman-detection-of-pulmonary-micrometastases
#4
Tapas R Nayak, Chrysafis Andreou, Anton Oseledchyk, Warren D Marcus, Hing C Wong, Joan Massagué, Moritz F Kircher
Here we demonstrate a novel application of 'surface enhanced resonance Raman scattering nanoparticles' (SERRS NPs) for imaging breast cancer lung metastases with much higher precision than currently feasible. A breast cancer lung metastasis mouse model was established by intravenous injection of LM2 cells. These mice were intravenously administered SERRS NPs conjugated with ALT-836, an anti-tissue factor (TF) monoclonal antibody, and subjected to Raman imaging to visualize the expression of TF both in vivo and ex vivo...
January 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/27990312/ultra-extended-euthermic-pulsed-radiofrequency-for-the-treatment-of-ophthalmic-neuralgia-a-case-report-with-elaboration-of-a-new-technique
#5
Mohinish G Bhatjiwale, Mrudul M Bhatjiwale, Ami Bhagat
BACKGROUND: Pulsed radiofrequency although present for many years has been used little compared to ablative procedures for pain relief. Its use in trigeminal neuralgia is sparse and unreported in the ophthalmic division, where the possibility of sensory loss can lead to high morbidity. We wished to explore the potential of this reportedly safe modality for a prolonged duration in a highly sensitive anatomic neural location, however, in a very secure, structured, and staged manner. CASE DESCRIPTION: A patient suffering from ophthalmic division (V1) medically uncontrolled neuralgia with a preoperative visual analog scale (VAS) score of 9/10 was subjected to a percutaneous pain relief procedure...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27989810/needleoscopic-conservative-staging-of-borderline-ovarian-tumor
#6
Salvatore Gueli Alletti, Cristiano Rossitto, Emanuele Perrone, Stefano Cianci, Ilaria De Blasis, Anna Fagotti, Giovanni Scambia
STUDY OBJECTIVE: to investigate safeness and technical feasibility of needleoscopic fertility sparing staging of borderline ovarian tumor Design: video article and review of the literature SETTING: The patient was a 29 years old women affected by right ovarian cyst suspected for BOT at preoperative MRI and US due to the presence of a right unilocular ovarian cyst with a papillary projection. Informed consent for abdominal or laparoscopic approach was obtained from the patient in accordance with the local legislation...
October 27, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27878600/narrow-band-imaging-for-early-diagnosis-of-epithelial-dysplasia-and-microinvasive-tumors-in-the-upper-aerodigestive-tract
#7
C Arens, C Betz, M Kraft, S Voigt-Zimmermann
The various stages of tumor growth are characterized by typical epithelial, vascular, and secondary connective tissue changes. Narrow Band Imaging (NBI) endoscopy is a minimally invasive imaging technique that presents vascular structures in particular at a higher contrast than white light endoscopy alone. In combination with high-resolution image recording and reproduction (high-definition television, HDTV; ultra-high definition, 4K), progress has been made in otolaryngological differential diagnostics, both pre- and intraoperatively...
November 23, 2016: HNO
https://www.readbyqxmd.com/read/27825874/ultra-miniaturization-of-a-planar-amperometric-sensor-targeting-continuous-intradermal-glucose-monitoring
#8
Federico Ribet, Göran Stemme, Niclas Roxhed
An ultra-miniaturized electrochemical biosensor for continuous glucose monitoring (CGM) is presented. The aim of this work is to demonstrate the possibility of an overall reduction in sensor size to allow minimally invasive glucose monitoring in the interstitial fluid in the dermal region, in contrast to larger state-of-the-art systems, which are necessarily placed in the subcutaneous layer. Moreover, the reduction in size might be a key factor to improve the stability and reliability of transdermal sensors, due to the reduction of the detrimental foreign body reaction and of consequent potential failures...
April 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27823804/a-non-ionizing-technique-for-three-dimensional-measurement-of-the-lumbar-spine
#9
Terry K Koo, Wingchi Edmund Kwok
Comprehensive assessments of scoliotic deformity and spinal instability require repetitive three-dimensional (3D) measurements of motion segments at different functional postures. However, accurate 3D measurement of the spine is a challenging task. In this paper, we present a novel, non-invasive, non-ionizing technique to quantify 3D poses of lumbar motion segments in terms of clinically meaningful anatomical coordinates. The technique used ultra-short echo time (UTE) magnetic resonance (MR) images to construct subject-specific geometrical models of individual vertebrae and registered them with 3D ultrasound dataset acquired during pose measurements...
December 8, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27782402/3d-printing-of-photoresponsive-biomaterials-for-control-of-bacterial-microenvironments
#10
Jodi L Connell, Eric T Ritschdorff, Jason B Shear
Advances in microscopic three-dimensional (µ3D) printing provide a means to microfabricate an almost limitless range of arbitrary geometries, offering new opportunities to rapidly prototype complex architectures for microfluidic and cellular applications. Such 3D lithographic capabilities present the tantalizing prospect for engineering micromechanical components - for example, pumps and valves - for cellular environments comprised of smart materials whose size, shape, permeability, stiffness, and other attributes might be modified in real time to precisely manipulate ultra-low-volume samples...
October 26, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27735191/editorial-comment-for-demirbas-et-al
#11
Mordechai Duvdevani
No abstract text is available yet for this article.
December 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27716217/ultrasound-guided-gastrocnemius-recession-a-new-ultra-minimally-invasive-surgical-technique
#12
Manuel Villanueva, Álvaro Iborra, Guillermo Rodríguez, Pablo Sanz-Ruiz
BACKGROUND: Isolated gastrocnemius contracture is thought to lead to numerous conditions. Although many techniques have been described for gastrocnemius recession, potential anesthetic, cosmetic, and wound-related complications can lead to patient dissatisfaction. Open and endoscopic recession techniques require epidural anesthesia, lower limb ischemia, and stitches and may lead to damage of the sural nerve, which is not under the complete control of the surgeon at all stages of the procedure...
October 3, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27659697/minimally-invasive-sacrocolpopexy-how-to-avoid-short-and-long-term-complications
#13
REVIEW
Catherine A Matthews
Sacrocolpopexy remains the "gold standard" procedure for management of posthysterectomy vaginal vault prolapse with improved anatomic outcomes compared to native tissue vaginal repair. Despite absence of clinical data, sacrocolpopexy is increasingly being offered to women as a primary treatment intervention for uterine prolapse. While reoperation rates remain low, recurrent prolapse and vaginal mesh exposure appear to increase over time. The potential morbidity associated with sacrocolpopexy is higher than for native tissue vaginal repair with complications including sacral hemorrhage, discitis, small bowel obstruction, port site herniation, and mesh erosion...
November 2016: Current Urology Reports
https://www.readbyqxmd.com/read/27531099/sinvict-ultra-sensitive-detection-of-single-nucleotide-variants-and-indels-in-circulating-tumour-dna
#14
Can Kockan, Faraz Hach, Iman Sarrafi, Robert H Bell, Brian McConeghy, Kevin Beja, Anne Haegert, Alexander W Wyatt, Stanislav V Volik, Kim N Chi, Colin C Collins, S Cenk Sahinalp
MOTIVATION: Successful development and application of precision oncology approaches require robust elucidation of the genomic landscape of a patient's cancer and, ideally, the ability to monitor therapy-induced genomic changes in the tumour in an inexpensive and minimally invasive manner. Thanks to recent advances in sequencing technologies, 'liquid biopsy', the sampling of patient's bodily fluids such as blood and urine, is considered as one of the most promising approaches to achieve this goal...
January 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/27509373/minimally-invasive-percutaneous-nephrolithotomy-guided-by-ultrasonography-to-treat-upper-urinary-tract-calculi-complicated-with-severe-spinal-deformity
#15
Zhaohui He, Caixia Zhang, Guohua Zeng
OBJECTIVE: To report our experience of minimally invasive percutaneous nephrolithotomy(MPCNL) in managing upper urinary tract calculi complicated with severe spinal deformity. MATERIALS AND METHODS: Between August 2001 to December 2012, 16 upper urinary calculi in 13 patients with severe spinal deformity were treated by MPCNL. Preoperative investigation of the respiratory function, evaluation of anatomy by intravenous uro¬graphy (IVU) and CT scan, and preoperative kidney ultrasonagraphy with simulation of the percutaneous puncture were performed in all patients...
August 10, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27354182/no-prep-rehabilitation-of-fractured-maxillary-incisors-with-partial-veneers
#16
Mirco Vadini, Maurizio D'Amario, Francesco De Angelis, Antonello Falco, Camillo D'Arcangelo
OBJECTIVE: Therapeutic options for dental trauma depend on the injuries' features. For patients with uncomplicated tooth fractures, adhesive materials and composite partial veneers may be a therapeutic solution that completely preserves healthy tooth structure. CLINICAL CONSIDERATIONS: An ultra-conservative approach, using indirect composite partial veneers to restore fractured anterior teeth is described in these case reports. CONCLUSION: Despite the position of the finish line in the middle of the clinical crown, this solution offers functional and esthetic outcomes using an indirect composite technique, and appears to be a suitable alternative to direct composite restorations or less conservative indirect veneers...
November 12, 2016: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/27254655/an-internally-randomized-control-trial-of-radiation-exposure-using-ultra-low-radiation-imaging-ulri-versus-traditional-c-arm-fluoroscopy-for-patients-undergoing-single-level-minimally-invasive-transforaminal-lumbar-interbody-fusion-tlif
#17
Timothy Y Wang, S Harrison Farber, Scott S Perkins, Adam G Back, Sarah A Byrd, Debbie Chi, David Vincent, Isaac O Karikari
STUDY DESIGN: Randomized controlled trial OBJECTIVE.: Compare radiation exposure between ultra-low radiation imaging (ULRI) with image enhancement and standard-dose fluoroscopy for patients undergoing minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) SUMMARY OF BACKGROUND DATA.: While the benefits of MIS are lauded by many, there is a significant amount of radiation exposure to surgeon and operating room (OR) personnel. Our goal with this work was to see if by using ultra-low dose radiation settings coupled with image enhancement, this exposure could be minimized...
May 31, 2016: Spine
https://www.readbyqxmd.com/read/27238726/bold-fmri-in-awake-prairie-voles-a-platform-for-translational-social-and-affective-neuroscience
#18
J R Yee, W M Kenkel, P Kulkarni, K Moore, A M Perkeybile, S Toddes, J A Amacker, C S Carter, C F Ferris
The advancement of neuroscience depends on continued improvement in methods and models. Here, we present novel techniques for the use of awake functional magnetic resonance imaging (fMRI) in the prairie vole (Microtus ochrogaster) - an important step forward in minimally-invasive measurement of neural activity in a non-traditional animal model. Imaging neural responses in prairie voles, a species studied for its propensity to form strong and selective social bonds, is expected to greatly advance our mechanistic understanding of complex social and affective processes...
September 2016: NeuroImage
https://www.readbyqxmd.com/read/27134840/future-of-uniportal-video-assisted-thoracoscopic-surgery-emerging-technology
#19
Zheng Li, Calvin S H Ng
Uniportal VATS poses unique difficulties to the surgeon, mainly as a consequence of operating through a small single incision. The instruments in uniportal VATS have limited movement through the small incision. In addition, the approach to the surgical operating site is unidirectional, which may restrict vision and retraction, and unavoidably suffers from instrument fencing. Recent thoracoscopic technology in the form of a wide variable angled lens has to some extent improved these shortcomings. The development of an extendable flexible thoracoscope and wireless steerable endoscope (WSE) systems can further improve the visualization for surgery and reduce or even remove fencing between endoscope and instruments...
March 2016: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27128246/a-comprehensive-approach-to-multimodal-facial-aesthetic-treatment-injection-techniques-and-treatment-characteristics-from-the-harmony-study
#20
Vic A Narurkar, Joel L Cohen, Steven Dayan, Michael S Kaminer, Alexander Rivkin, Ava Shamban, Jonathan M Sykes, Craig F Teller, Susan H Weinkle, W Philip Werschler, Adrienne Drinkwater, Michael L Pucci, Conor J Gallagher
BACKGROUND: The HARMONY study is the first clinical trial to assess the impact of a global approach to facial rejuvenation with several minimally invasive modalities, using patient-reported outcome measures. OBJECTIVE: Provide details of this treatment approach and describe investigators' experiences and recommendations based on this study. METHODS: This multicenter, 4-month study evaluated subject satisfaction with and psychological impact of combined treatment with VYC-20L (Juvéderm Voluma XC), HYC-24L (Juvéderm Ultra XC), HYC-24L+ (Juvéderm Ultra Plus XC), onabotulinumtoxinA (Botox), and bimatoprost 0...
May 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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