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https://www.readbyqxmd.com/read/29761211/comparative-study-of-uma-jeunesse-classic-%C3%A2-and-uma-jeunesse-ultra-%C3%A2
#1
Peeyush P Sharma, Dave Krishan Sharma, Andrew Carr
INTRODUCTION: The emergence of hyaluronic acid dermal fillers with lidocaine has transformed the minimally invasive treatment of wrinkles, lines and folds of the face. Patients can be treated quickly, painlessly and without the need for large doses of lidocaine. Therefore, it is important to scientifically evaluate the merits of lidocaine-containing products over those without. METHODS: The two products, with (UJU) and without lidocaine (UJ), were randomly injected into nasolabial folds of 75 healthy volunteers with varying skin types in a split face study, age ranging 26-60 years...
May 14, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29719451/establishment-and-evaluation-of-the-vx2-orthotopic-lung-cancer-rabbit-model-a-ultra-minimal-invasive-percutaneous-puncture-inoculation-method
#2
Lijuan Wang, Keke Che, Zhonghong Liu, Xianlong Huang, Shifeng Xiang, Fei Zhu, Yu Yu
The purpose of the present work is to establish an ultra-minimal invasive percutaneous puncture inoculation method for a VX2 orthotopic lung cancer rabbit model with fewer technical difficulties, lower mortality of rabbits, a higher success rate and a shorter operation time, to evaluate the growth, metastasis and apoptosis of tumor by CT scans, necropsy, histological examination, flow cytometry and immunohistochemistry. The average inoculation time was 10-15 min per rabbit. The tumor-bearing rate was 100%. More than 90% of the tumor-bearing rabbits showed local solitary tumor with 2-10 mm diameters after two weeks post-inoculation, and the rate of chest seeding was only 8...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29712562/endometrium-metabolomic-profiling-reveals-potential-biomarkers-for-diagnosis-of-endometriosis-at-minimal-mild-stages
#3
Jingjie Li, Lihuan Guan, Huizhen Zhang, Yue Gao, Jiahong Sun, Xiao Gong, Dongshun Li, Pan Chen, Xiaoyan Liang, Min Huang, Huichang Bi
BACKGROUND: The sensitivity and specificity of non-invasive diagnostic methods for endometriosis, especially at early stages, are not optimal. The clinical diagnostic indicator cancer antigen 125 (CA125) performs poorly in the diagnosis of minimal endometriosis, with a sensitivity of 24%. Therefore, it is urgent to explore novel diagnostic biomarkers. We evaluated the metabolomic profile variation of the eutopic endometrium between minimal-mild endometriosis patients and healthy women by ultra-high-performance liquid chromatography coupled with electrospray ionization high-resolution mass spectrometry (UHPLC-ESI-HRMS)...
April 30, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29707555/lumbar-disc-reherniation-after-transforaminal-lumbar-endoscopic-discectomy
#4
Thomas A Kosztowski, David Choi, Jared Fridley, Michael Galgano, Ziya Gokaslan, Adetokunbo Oyelese, Albert Edward Telfeian
Background: Transforaminal lumbar endoscopic discectomy is a minimally invasive surgical procedure that can be performed in awake patients through an incision less than 1 cm. The procedure requires very little bony removal to access the herniated disc material because the approach is through the foramen, and only a small amount of the superior articulating process is removed to access Kambin's triangle. This study describes our experience with transforaminal endoscopic lumbar decompression (TELD) for the treatment of lumbar disc herniation...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29703982/whole-exome-sequencing-of-cell-free-dna-and-circulating-tumor-cells-in-multiple-myeloma
#5
S Manier, J Park, M Capelletti, M Bustoros, S S Freeman, G Ha, J Rhoades, C J Liu, D Huynh, S C Reed, G Gydush, K Z Salem, D Rotem, C Freymond, A Yosef, A Perilla-Glen, L Garderet, E M Van Allen, S Kumar, J C Love, G Getz, V A Adalsteinsson, I M Ghobrial
Liquid biopsies including circulating tumor cells (CTCs) and cell-free DNA (cfDNA) have enabled minimally invasive characterization of many cancers, but are rarely analyzed together. Understanding the detectability and genomic concordance of CTCs and cfDNA may inform their use in guiding cancer precision medicine. Here, we report the detectability of cfDNA and CTCs in blood samples from 107 and 56 patients with multiple myeloma (MM), respectively. Using ultra-low pass whole-genome sequencing, we find both tumor fractions correlate with disease progression...
April 27, 2018: Nature Communications
https://www.readbyqxmd.com/read/29682704/-anastomotic-leakage-after-rectal-cancer-surgery-classification-and-management
#6
Pan Chi, Shenghui Huang
Many studies have focused on the identification of risk factors and prevention of anastomotic leakage following rectal cancer surgery. However, there is little knowledge regarding classification and management of anastomotic leakage in clinic. Herein, we reviewed and summarized the classification and management of anastomotic leakage after rectal cancer surgery. The relevant treatments of anastomotic leakage should be chosen based on patient's manifestation, including general and local reactions, anatomical location, and nature of the leakage (contained or free, controlled or uncontrolled leakage)...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29675297/minimally-invasive-multimode-optical-fiber-microendoscope-for-deep-brain-fluorescence-imaging
#7
Shay Ohayon, Antonio Caravaca-Aguirre, Rafael Piestun, James J DiCarlo
A major open challenge in neuroscience is the ability to measure and perturb neural activity in vivo from well defined neural sub-populations at cellular resolution anywhere in the brain. However, limitations posed by scattering and absorption prohibit non-invasive multi-photon approaches for deep (>2mm) structures, while gradient refractive index (GRIN) endoscopes are relatively thick and can cause significant damage upon insertion. Here, we present a novel micro-endoscope design to image neural activity at arbitrary depths via an ultra-thin multi-mode optical fiber (MMF) probe that has 5-10X thinner diameter than commercially available micro-endoscopes...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29649748/rapid-and-selective-sampling-of-igg-from-skin-in-less-than-1-min-using-a-high-surface-area-wearable-immunoassay-patch
#8
Jacob W Coffey, Simon R Corrie, Mark A F Kendall
Microprojection array (MPA) patches are an attractive approach to selectively capture circulating proteins from the skin with minimal invasiveness for diagnostics at the point-of-care or in the home. A key challenge to develop this technology is to extract sufficient quantities of specific proteins from within the skin to enable high diagnostic sensitivity within a convenient amount of time. To achieve this, we investigated the effect of MPA geometry (i.e. projection density, length and array size) on protein capture...
March 22, 2018: Biomaterials
https://www.readbyqxmd.com/read/29628508/a-pilot-study-of-ultra-deep-targeted-sequencing-of-plasma-dna-identifies-driver-mutations-in-hepatocellular-carcinoma
#9
Ismail Labgaa, Carlos Villacorta-Martin, Delia D'Avola, Amanda J Craig, Johann von Felden, Sebastiao N Martins-Filho, Daniela Sia, Ashley Stueck, Stephen C Ward, M Isabel Fiel, Milind Mahajan, Parissa Tabrizian, Swan N Thung, Celina Ang, Scott L Friedman, Josep M Llovet, Myron Schwartz, Augusto Villanueva
Cellular components of solid tumors including DNA are released into the bloodstream, but data on circulating-free DNA (cfDNA) in hepatocellular carcinoma (HCC) are still scarce. This study aimed at analyzing mutations in cfDNA and their correlation with tissue mutations in patients with HCC. We included 8 HCC patients treated with surgical resection for whom we collected paired tissue and plasma/serum samples. We analyzed 45 specimens, including multiregional tumor tissue sampling (n = 24), peripheral blood mononuclear cells (PMBC, n = 8), plasma (n = 8) and serum (n = 5)...
April 9, 2018: Oncogene
https://www.readbyqxmd.com/read/29529359/tissue-like-neural-probes-for-understanding-and-modulating-the-brain
#10
Guosong Hong, Robert D Viveros, Theodore J Zwang, Xiao Yang, Charles M Lieber
Electrophysiology tools have contributed substantially to understanding brain function, yet the capabilities of conventional electrophysiology probes have remained limited in key ways due to large structural and mechanical mismatches with respect to neural tissue. In this Perspective, we discuss how the general goal of probe design in biochemistry - that the probe or label has a minimal impact on the properties and function of the system being studied - can be realized by minimizing structural, mechanical and topological differences between neural probes and brain tissue, thus leading to a new paradigm of tissue-like mesh electronics...
March 12, 2018: Biochemistry
https://www.readbyqxmd.com/read/29516304/role-of-minimally-invasive-micro-and-ultra-mini-pcnl-for-adult-urinary-stone-disease-in-the-modern-era-evidence-from-a-systematic-review
#11
REVIEW
Patrick Jones, Muhammad Elmussareh, Omar M Aboumarzouk, Phillip Mucksavage, Bhaskar K Somani
PURPOSE OF REVIEW: The role of PCNL and the expertise surrounding it has expanded in recent decades. Miniaturisation of equipment and instrument size has formed a part of this innovation. Although an increasing number of studies have been performed on miniaturised PCNL (Mi-PCNL) recently, a critical appraisal on these is lacking. We therefore conducted a systematic review of the literature to evaluate the efficacy, safety and feasibility of Mi-PCNL techniques (< 15 Fr). RECENT FINDINGS: A systematic review was conducted from 1990 to March 2017 on outcomes of Mi-PCNL [micro PCNL (m-PCNL) and ultra-mini PCNL (UMP)] in adult patients...
March 7, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29513312/electrochemical-and-surface-plasmon-insulin-assays-on-clinical-samples
#12
REVIEW
Vini Singh, Sadagopan Krishnan
Diabetes is a complex immune disorder that requires extensive medical care beyond glycemic control. Recently, the prevalence of diabetes, particularly type 1 diabetes (T1D), has significantly increased from 5% to 10%, and this has affected the health-associated complication incidences in children and adults. The 2012 statistics by the American Diabetes Association reported that 29.1 million Americans (9.3% of the population) had diabetes, and 86 million Americans (age ≥20 years, an increase from 79 million in 2010) had prediabetes...
March 26, 2018: Analyst
https://www.readbyqxmd.com/read/29432386/validation-of-a-reversed-phase-ultra-high-performance-liquid-chromatographic-method-with-photodiode-array-detection-for-the-determination-of-voriconazole-in-human-serum-and-its-application-to-therapeutic-drug-monitoring
#13
Ignacio G Bressán, Mariana L Mendez, María I Gimenez
BACKGROUND: Voriconazole is a broad-spectrum triazole antifungal agent. It is widely used in the treatment of invasive fungal infections in immunocompromised patients. Because the pharmacokinetics of voriconazole demonstrates considerable variability, monitoring its serum levels plays an important role in optimizing therapies against many clinically relevant fungal pathogens. The aim of this study was to validate a simple and rapid U-HPLC-PDA method with minimal sample preparation for routine therapeutic drug monitoring (TDM) of voriconazole...
April 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29410769/dental-gingival-remodeling-with-bopt-no-prep-veneers
#14
Rubén Agustín-Panadero, Daniel Ausina-Escrihuela, Lucía Fernández-Estevan, Juan-Luis Román-Rodríguez, Joan Faus-López, María-Fernanda Solá-Ruíz
Recent years have seen increasing demand for treatments aimed at improving dental esthetics. In this context, both patients and dentists prefer to preserve dental structures as far as possible; thanks to technological advances, especially in adhesive dentistry, new materials and minimally invasive techniques such as "no-prep" (no preparation) veneers have made this possible. Nevertheless, no-prep veneers have specific indications and suffer certain disadvantages. OBJECTIVES: This clinical case describes the rehabilitation of the upper anterior region by means of no-prep veneers, with BOPT (Biologically Oriented Preparation Technique) cervical margins...
December 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29370357/ultra-fast-track-minimally-invasive-aortic-valve-replacement-going-beyond-reduced-incisions
#15
Marco Di Eusanio, Walter Vessella, Roberto Carozza, Filippo Capestro, Alessandro D'Alfonso, Carlo Zingaro, Christopher Munch, Paolo Berretta
Aortic valve replacement (AVR) via a median sternotomy approach has been largely reported to be safe and long-term efficacious, and currently represents the 'gold standard' approach for aortic stenosis treatment. However, aortic valve surgery has undergone continuous development over the last years, involving less invasive techniques and new technologies to reduce the traumatic impact of the intervention and extend the operability toward increasingly high-risk patients. Indeed, minimally invasive AVR and transcatheter aortic valve replacement caseload have steadily increased leading to a paradigm shift in the treatment of aortic valve disease...
January 23, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29302294/severe-tetracycline-dental-discoloration-restoration-with-conventional-feldspathic-ceramic-veneers-a-clinical-report
#16
Vicente Faus-Matoses, Ignacio Faus-Matoses, Esther Ruiz-Bell, Vicente J Faus-Llácer
The treatment of severe tetracycline discoloration is a challenge for the dentist. There are several treatment options and one of the most effective is the use of feldspathic veneers. The aim of this clinical case was to carry out the replacement with conventional feldspathic ceramic veneers on a patient with highly stained teeth (grade IV tetracycline) by a minimally invasive approach. Clinical examination revealed gingival retraction, color change of the veneers, ceramic cracked of 1.1 and 1.3 and incisal wear in lower anterior teeth...
November 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29234531/ultra-mini-percutaneous-nephrolithotomy-pcnl-versus-standard-pcnl-a-randomised-clinical-trial
#17
Ramin Haghighi, Hossein Zeraati, Maryam Ghorban Zade
Objective: To assess the effectiveness and advantages of ultra-mini-percutaneous nephrolithotomy (UM-PCNL) versus standard PCNL (S-PCNL), as one of the most important differences between the various PCNL techniques is the size of the renal access, which contributes to the broad spectrum of complications and outcomes. Patients and methods: This clinical randomised trial was conducted in 2016. In all, 70 patients with renal or upper ureteric stones of 10-20 mm in diameter, who were candidates for PCNL, were divided equally into two groups...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29220192/fluidic-microactuation-of-flexible-electrodes-for-neural-recording
#18
Flavia Vitale, Daniel G Vercosa, Alexander V Rodriguez, Sushma Sri Pamulapati, Frederik Seibt, Eric Lewis, J Stephen Yan, Krishna Badhiwala, Mohammed Adnan, Gianni Royer-Carfagni, Michael Beierlein, Caleb Kemere, Matteo Pasquali, Jacob T Robinson
Soft and conductive nanomaterials like carbon nanotubes, graphene, and nanowire scaffolds have expanded the family of ultraflexible microelectrodes that can bend and flex with the natural movement of the brain, reduce the inflammatory response, and improve the stability of long-term neural recordings. However, current methods to implant these highly flexible electrodes rely on temporary stiffening agents that temporarily increase the electrode size and stiffness thus aggravating neural damage during implantation, which can lead to cell loss and glial activation that persists even after the stiffening agents are removed or dissolve...
January 10, 2018: Nano Letters
https://www.readbyqxmd.com/read/29218393/-microperc-micropercutaneous-nephrolithotomy-a-review-of-the-literature
#19
REVIEW
Arvind P Ganpule, Jaspreet Chabra, Mahesh R Desai
Recent years have seen innovations in working armamentarium of percutaneous nephrolithotomy (PCNL) leading to development of novel modifications such as miniperc, ultra miniperc, and microperc. Amongst these microperc appears to be least invasive and various authors, off late, have reported their experience with the technique. Literature on microperc was reviewed by a MEDLINE/PubMed search with articles in the English language since 2011 in published peer-reviewed journals. Articles comprised of case series, comparative, and noncomparative studies...
February 2018: Urolithiasis
https://www.readbyqxmd.com/read/29192879/pedicle-screw-placement-accuracy-using-ultra-low-radiation-imaging-with-image-enhancement-versus-conventional-fluoroscopy-in-minimally-invasive-transforaminal-lumbar-interbody-fusion-an-internally-randomized-controlled-trial
#20
Gautam Nayar, Daniel J Blizzard, Timothy Y Wang, Steven Cook, Adam G Back, David Vincent, Isaac O Karikari
OBJECTIVE A previous study found that ultra-low radiation imaging (ULRI) with image enhancement significantly decreases radiation exposure by roughly 75% for both the patient and operating room personnel during minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) (p < 0.001). However, no clinical data exist on whether this imaging modality negatively impacts patient outcomes. Thus, the goal of this randomized controlled trial was to assess pedicle screw placement accuracy with ULRI with image enhancement compared with conventional, standard-dose fluoroscopy for patients undergoing single-level MIS-TLIF...
February 2018: Journal of Neurosurgery. Spine
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