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https://www.readbyqxmd.com/read/28808756/relationship-between-18-f-fluorodeoxyglucose-accumulation-and-the-braf-v600e-mutation-in-papillary-thyroid-cancer
#1
Jae Won Chang, Ki Wan Park, Jae Hyung Heo, Seung-Nam Jung, Lihua Liu, Sung Min Kim, In Sun Kwon, Bon Seok Koo
BACKGROUND: To determine whether (18)F-fluoro-2-deoxyglucose ((18)F-FDG)-PET/CT is useful for predicting the BRAF (V600E) mutation status of a primary papillary thyroid carcinoma (PTC). METHODS: A retrospective analysis was performed in 108 patients who underwent (18)F-FDG positron emission tomography-computed tomography (PET/CT) for staging before thyroidectomy and BRAF analysis in biopsy-confirmed PTC. The maximum standardized uptake value (SUVmax) of the primary tumor was calculated according to FDG accumulation...
August 14, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28806249/epidural-metastases-from-follicular-thyroid-cancer-mimicking-meningiomas-in-68ga-dotatate-pet
#2
Marcus Unterrainer, Harun Ilhan, Andrei Todica, Peter Bartenstein, Nathalie Lisa Albert
We report a woman with multifocal lesions suggestive of meningiomas in MRI, which also presented with high Ga-DOTATATE uptake in PET, a finding characteristic for meningioma. A whole-body staging due to a pathological fracture revealed multiple neoplastic lesions throughout the body without detection of a primary site. Subsequent pathological workup of a lung lesion revealed multifocal metastases from follicular thyroid cancer despite thyroidectomy 10 years ago (without pathological finding), and posttreatment scans after radioiodine therapy confirmed the multiple brain lesions to be metastases as well...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28793848/18f-fdg-pet-ct-may-exclude-malignancy-in-sonographically-suspicious-and-scintigraphically-hypofunctional-thyroid-nodules-and-reduce-unnecessary-thyroid-surgeries
#3
Marcus Ruhlmann, Jürgen Ruhlmann, Rainer Görges, Ken Herrmann, Gerald Antoch, Hans-Wilhelm Keller, Verena Ruhlmann
BACKGROUND: The aim of this study was to evaluate whether [18F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful in the further characterization of sonographically suspicious and scintigraphically hypofunctional thyroid nodules. METHODS: 65 patients with a sonographically suspicious thyroid nodules that were hypofunctional on 99m-Tc-pertechnetate scintigraphy (diameter > 1 cm) were retrospectively analyzed. All patients underwent evaluation with FDG-PET/CT...
August 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28789759/-work-up-of-thyroid-incidentalomas-identified-by-18-f-fluorodeoxyglucose-pet-ct
#4
Ali Asmar, Lene Simonsen, Jens Bülow, Meena Asmar
Several reports have described dramatic increase over recent decades in the incidence of thyroid cancer, even as thyroid cancer-related mortality rates have not changed substantially. Nevertheless, in several retrospective studies the incidence of malignancy in focal (18)F-fluorodeoxyglucose (FDG) thyroid uptake discovered on whole body (18)F-FDG PET/CT, carried out for non-thyroid cancers, is 13-64%. Our aim was to design a practical algorithm for management of an increasing number of thyroid incidentalomas, identified by (18)F-FDG PET/CT...
July 17, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28759522/thyroid-metastasis-as-first-manifestation-of-a-colon-adenocarcinoma-with-kras-mutation-usefulness-of-18f-fdg-pet-ct
#5
Beatriz Lecumberri, Elena López, Mónica Coronado, Sonia Rodado, Beatriz Castelo
The synchronous diagnosis of a thyroid metastasis and of the primary colon adenocarcinoma that produces it is very rare, with only 5 cases reported to date, all of them treated with thyroid surgery showing a mean survival of 7 months. An ¹⁸F-FDG PET/CT in an asymptomatic 74-year-old woman with a thyroid cytology suggestive of malignancy but uncertain about the origin of the tumor revealed an stage IV colon adenocarcinoma with KRAS mutation and multiple metastasis (thyroid, lung, and liver). A prompt therapeutic planning with chemotherapy allowed 21 months of survival...
July 29, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28746199/18f-fdg-pet-ct-imaging-of-atypical-subacute-thyroiditis-in-thyrotoxicosis-a-case-report
#6
Katsuya Yoshida, Hidetaka Yokoh, Akira Toriihara, Hayahiko Fujii, Naoki Harata, Jun Isogai, Ukihide Tateishi
BACKGROUND: In addition to its established role in oncologic imaging, F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) is useful for the assessment of inflammatory activity. However, subacute thyroiditis (SAT) in thyrotoxicosis is rarely detected during these scans. CASE: A 66-year-old man with SAT in thyrotoxicosis demonstrated symptoms of transient fatigue, headache, and fever, without typical neck pain. Using F-FDG PET/CT, we found increased F-FDG uptake in the thyroid gland, predominantly in the right side due to SAT...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28740088/functional-correlates-of-tsh-ft3-and-ft4-in-alzheimer-disease-a-f-18-fdg-pet-ct-study
#7
Agostino Chiaravalloti, Francesco Ursini, Alessandro Fiorentini, Gaetano Barbagallo, Alessandro Martorana, Giacomo Koch, Mario Tavolozza, Orazio Schillaci
The present study was aimed to investigate the relationships between thyroid stimulating hormone (TSH), freeT3 (fT3) and freeT4 (fT4) and brain glucose consumption as detectable by means of 2-deoxy-2-(F-18) fluoro-D-glucose (F-18 FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in a selected population with Alzheimer disease (AD). We evaluated 87 subjects (37 males and 50 females, mean age 70 (±6) years old) with AD. All of them were subjected to TSH, fT3 and fT4 assay and to cerebrospinal fluid amyloid (Aβ1-42) and tau [phosphorylated-tau (p-tau) and total-tau (t-tau)] assay prior PET/CT examination...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28733959/increasing-precision-of-clinical-diagnosis-of-alzheimer-s-disease-using-a-combined-algorithm-incorporating-clinical-and-novel-biomarker-data
#8
REVIEW
Marwan N Sabbagh, Lih-Fen Lue, Daniel Fayard, Jiong Shi
Establishing the in vivo diagnosis of Alzheimer's disease (AD) or other dementias relies on clinical criteria; however, the accuracy of these criteria can be limited. The diagnostic accuracy is 77% for a clinical diagnosis of AD, even among experts. We performed a review through PubMed of articles related to specific diagnostic modalities, including APOE genotyping, cerebrospinal fluid (CSF) testing, fludeoxyglucose F 18 positron emission tomography (PET), amyloid PET, tau PET, computed tomography (CT), single-photon emission CT, magnetic resonance imaging (MRI), and B12 and thyroid-stimulating hormone screening, to determine the specificity and sensitivity of each test used in the clinical diagnosis of AD...
July 2017: Neurology and Therapy
https://www.readbyqxmd.com/read/28729431/sandostatin-lar-therapy-differentially-alters-68-ga-dotatate-uptake-in-normal-tissues-compared-to-primary-tumors-and-metastatic-lesions
#9
Narjess Ayati, Sze Ting Lee, Seyed Rasoul Zakavi, Kunthi Pathmaraj, Loai Qatawneh, Aurora Poon, Andrew Scott
Synthetic somatostatin analogs have been posed as a potential source of error in somatostatin receptor imaging by interfering with tumor detection; however, experimental models and clinical studies have shown a complex mechanism of octreotide effect on tumors. This study aimed to assess whether (68)Ga-DOTATATE uptake differs before and after treatment with long-acting somatostatin analogs. Methods: Thirty patients with intermediate to well differentiated neuroendocrine tumors (NET) who underwent (68)Ga-DOTATATE Positron Emission Tomography/Computed Tomography (PET/CT) scanning before and after receiving long-acting repeatable (LAR) Sandostatin were included in the study...
July 20, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28718944/the-effect-of-routine-radiological-reporting-of-thyroid-incidentalomas-on-rates-of-thyroid-needle-biopsy-thyroid-surgery-and-detection-of-thyroid-malignancy
#10
J D Sinnott, R Mortimer, J Smith, E Skelton, K Drinkwater, D Lipscomb, D C Howlett
OBJECTIVE: This study looked at the effect of a changing radiology reporting policy to routinely review the thyroid gland where visible and report on any thyroid lesion, recommending further investigation as appropriate. CONTEXT: Incidentaloma is a term used to describe a lesion found on imaging unrelated to the clinical issue under investigation. There is variability in the radiological reporting of thyroid incidentalomas and conflicting recommendations as to how these lesions should be managed...
July 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28704342/a-novel-compact-small-field-of-view-hybrid-gamma-camera-first-clinical-results
#11
Aik H Ng, Patricia E Blackshaw, Mohammed S Alqahtani, Layal K Jambi, Sarah L Bugby, John E Lees, Alan C Perkins
INTRODUCTION: Hybrid imaging has proven to be a major innovation in nuclear medicine, allowing the fusion of functional information with anatomical detail. In the past, the use of hybrid imaging such as PET-CT, PET-MRI and SPECT-CT has been of great clinical benefit; however, these scanners are relatively large and bulky. We have developed and investigated the clinical application of a compact small field of view hybrid gamma camera (HGC) that is suitable for small-organ imaging at the patient bedside...
July 12, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28693291/diagnostic-clue-of-nodular-fasciitis-mimicking-metastasis-in-papillary-thyroid-cancer-mismatching-findings-on-18-f-fdg-pet-ct-and-123-i-whole-body-scan-a-case-report
#12
Minjung Seo, Misung Kim, Eun Sook Kim, Hongbo Sim, Sungmin Jun, Seol Hoon Park
This study reports a case of nodular fasciitis incidentally detected in a patient with papillary thyroid cancer. A 47-year-old woman underwent a total thyroidectomy and radioactive iodine therapy for papillary thyroid cancer. On a follow-up fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) scan after 12 months, a focal (18)F-FDG-avid lesion was incidentally detected in the paraspinal muscle. It was well-enhanced on CT and magnetic resonance imaging, indicating metastasis. However, the lesion was not iodine avid on the (123)I whole body scan, which favored benign etiology over metastasis from thyroid cancer...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28680197/association-between-volumetric-analysis-of-lung-metastases-on-f-18-fluoro-2-deoxy-d-glucose-positron-emission-tomography-computed-tomography-and-short-term-progression-after-i-131-therapy-for-differentiated-thyroid-carcinoma
#13
Yasuhiro Maruoka, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Koichiro Abe, Masayuki Sasaki, Hiroshi Honda
PURPOSE: Lung metastases (LMs) and their radioiodine uptake affect prognosis in patients with differentiated thyroid carcinoma (DTC). We herein investigate the value of metabolic tumor volume (MTV) in LMs on positron emission tomography/computed tomography (PET/CT) using 2-[F-18]-fluoro-2-deoxy-D-glucose (F-18 FDG PET/CT) in predicting short-term progression after initial I-131 therapy in DTC patients. MATERIALS AND METHODS: We retrospectively evaluated 111 DTC patients with LMs...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28673886/newly-diagnosed-sellar-tumors-in-cancer-patients-a-diagnostic-challenge-and-management-dilemma
#14
Carlos R Goulart, Smita Upadhyay, Leo F S Ditzel Filho, Andre Beer-Furlan, Ricardo L Carrau, Luciano M Prevedello, Daniel M Prevedello
OBJECTIVE: The use of PET CT for staging in cancer patients and the widespread use of MRI led to an increased incidence of incidental sellar mass detection. The imaging findings can be suggestive of a benign pituitary tumor but metastasis can never be completely ruled out with non-invasive work-up. Appropriate diagnosis of these sellar masses is critical as the treatment paradigm might change in the presence of a pituitary metastasis. Moreover, definitive tissue diagnosis might prevent unnecessary radiotherapy to the skull base or even the need for systemic treatment when benign pituitary disease is confirmed...
June 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28671105/report-small-cell-neuroendocrine-carcinoma-scnec-of-the-tongue-a-case-report
#15
Li-Wei Xue, Xiao Chen, Dan-Dan Yin, Xu-Xia Wang
Small cell neuroendocrine carcinoma (SCNEC) of the tongue is very rare. We here present a SCNEC impatient with distant metastasis. A 74-year-old Chinese male went to hospital to treat a tongue tumor, which was founded at a conventional physical examination in Weifang Stomatology Hospital. The check of positron emission tomography-computer tomography (PET-CT) by Weifang people's hospital revealed a tumor in the right root of tongue, and distant metastasis in the right submandibular area, neck, mediastinum, right hilar, abdominal, retroperitoneal multiple lymph nodes, left thyroid, right lower lung, right scapula and bilateral adrenal...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28670185/presentation-of-unusual-tracheal-metastasis-on-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-after-9-years-in-postnephrectomy-patient-of-renal-cell-carcinoma-a-case-report-and-review-of-literature
#16
Rahul Vithalrao Parghane, Ashwani Sood, Kim Vaiphei, Ashutosh Nath Aggarwal, Bhagwant Rai Mittal
Tracheal metastases from renal cell carcinoma (RCC) are extremely rare. Most common primary malignancy metastasizing to this unusual location usually comes from lung region while it is rare to have tracheal metastases from nonpulmonary malignancies such as breast, thyroid, colorectal carcinoma, and melanoma. The lesions detected on fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) scan, especially in the head and neck region, soft tissue, and muscular compartment during follow-up of RCC patients raise the possibility of metastatic lesions in these regions, though rarely encountered...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28662092/estimated-collective-effective-dose-to-the-population-from-nuclear-medicine-diagnostic-procedures-in-croatia-a-comparison-of-2010-and-2015
#17
Ivana Kralik, Mario Štefanić, Hrvoje Brkić, Gordan Šarić, Stanko Težak, Svjetlana Grbac Ivanković, Neva Griotto, Damir Štimac, Otmar Rubin, Tamer Salha, Zrinka Ivanišević, Slaven Jurković, Dario Faj
OBJECTIVE: This study presents national surveys of patient exposure from nuclear medicine (NM) diagnostic procedures in 2010 and 2015 in the Republic of Croatia. METHODS: The survey was performed according to the European Commission Dose DataMed (DDM) project methodology. 28 most frequent NM diagnostic procedures were identified. Data about frequencies of procedures and average administered activities of radioisotopes used in those procedures were collected. Average administered activities were converted to effective doses according to the dose conversion coefficients...
2017: PloS One
https://www.readbyqxmd.com/read/28662033/a-phase-i-study-of-pazopanib-in-combination-with-escalating-doses-of-131i-in-patients-with-well-differentiated-thyroid-carcinoma-borderline-refractory-to-radioiodine
#18
Laura Q Chow, Rafael Santana-Davila, Austin Pantel, Mara Roth, Leslie N Anderson, Alan Failor, Robert Doot, David Mankoff
OBJECTIVE: This trial was conducted to evaluate the ability of pazopanib to overcome therapeutic 131I resistance. MATERIALS, METHODS AND PATIENTS: This phase 1 trial assesses the combination of pazopanib and escalating doses of radioiodine (131I) in patients with recurrent or metastatic thyroid cancer that are borderline or relatively iodine refractory. Radioiodine uptake scans were assessed post therapy and compared to historical pre-treatment scans. Patients underwent FDG PET/CT before and after the initial pazopanib treatment to identify the impact of pazopanib on the cancer prior to 131I therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28649084/malignancy-rate-of-focal-thyroid-incidentaloma-detected-by-fdg-pet-ct-results-of-a-prospective-cohort-study
#19
Philippe Thuillier, Nathalie Roudaut, Geneviève Crouzeix, Marie Cavarec, Philippe Robin, Ronan Abgral, Véronique Kerlan, Pierre-Yves Salaun
OBJECTIVE: To evaluate the malignancy rate of focal thyroid incidentaloma (fTI) in a population of patients undergoing a 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) for a non-thyroid purpose. DESIGN: We conducted a prospective cohort study from January 2013 to November 2014. All consecutive patients referred for a FDG PET-CT were prospectively screened. Patients with known neoplastic thyroid disease were excluded from the analysis...
August 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28646462/diagnostic-utility-of-pet-ct-with-18-f-dopa-and-18-f-fdg-in-persistent-or-recurrent-medullary-thyroid-carcinoma-the-importance-of-calcitonin-and-carcinoembryonic-antigen-cutoff
#20
Ana Reyes Romero-Lluch, Juan Ignacio Cuenca-Cuenca, Raquel Guerrero-Vázquez, Antonio Jesús Martínez-Ortega, Juan Luis Tirado-Hospital, Isabel Borrego-Dorado, Elena Navarro-González
PURPOSE: This study sought to evaluate and compare the utility of 18-F-fluorodihydroxyphenylalanine ((18)F-DOPA) and 18-F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for identification of lesions in patients with recurrent medullary thyroid carcinoma (MTC). In addition, we analyzed the correlation between the calcitonin (Ct), carcinoembryonic antigen (CEA) levels, each doubling time (DT), and PET positivity. We evaluated the reliability of the 150 pg/mL Ct cutoff set by the American Thyroid Association guidelines for further imaging (including (18)F-DOPA PET/CT)...
June 23, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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