Mélissa Pagé, Catherine Maheux, Anick Langlois, Julyanne Brassard, Émilie Bernatchez, Sandra Martineau, Cyndi Henry, Marie-Josée Beaulieu, Ynuk Bossé, Mathieu C Morissette, Richard Debigaré, Marie-Renée Blanchet
Chronic obstructive pulmonary disease (COPD) can sometimes be associated with skeletal muscle atrophy. Hypoxemic episodes, which occur during disease exacerbation and daily physical activity, are frequent in COPD patients. However, the link between hypoxemia and muscle atrophy remains unclear, along with mechanisms of muscle hypoxic stress response. Myogenic progenitors (MPs) and fibro/adipogenic progenitors (FAPs) express CD34 and participate to muscle mass maintenance. Although there is evidence linking CD34 expression and muscle repair, the link between CD34 expression, muscle wasting and the hypoxic stress observed in COPD has never been studied...
December 2019: Journal of Muscle Research and Cell Motility