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https://www.readbyqxmd.com/read/28723125/pharmacokinetics-on-a-chip-using-label-free-sers-technique-for-programmable-dual-drug-analysis
#1
Jiayuan Fei, Lei Wu, Yizhi Zhang, Shenfei Zong, Zhuyuan Wang, Yiping Cui
Synergistic effects of dual or multiple drugs have attracted great attention in medical fields, especially in cancer therapies. We provide a programmable microfluidic platform for pharmacokinetic detection of multiple drugs in multiple cells. The well-designed microfluidic platform includes two 2 × 3 microarrays of cell chambers, two gradient generators, and several pneumatic valves. Through the combined use of valves and gradient generators, each chamber can be controlled to infuse different kinds of living cells and drugs with specific concentrations as needed...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28713502/the-effect-of-personality-traits-on-undergraduate-dental-students-performance-in-multiple-mini-interviews
#2
Lana Ahmed Shinawi, Sumer Madani Alaki, Ibrahim Yamany, Mona Hassan Ahmed Hassan
BACKGROUND: Multiple mini interviews (MMI) is a structured student selection method where applicants rotate around a series of stations that do not require previously learned knowledge. The Big Five Inventory (BFI) is a tool often used to measure personality traits commonly used in applicant selection. OBJECTIVE: The aim of the current study was to assess the effect of personality traits using the BFI on undergraduate dental students' performance in MMI. METHODS: This research was conducted at The Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28690285/myocardial-bridges-on-coronary-computed-tomography-angiography%C3%A3-correlation-with-intravascular-ultrasound-and-fractional-flow-reserve
#3
Signe Helene Forsdahl, Ian S Rogers, Ingela Schnittger, Shigemitsu Tanaka, Takumi Kimura, Vedant S Pargaonkar, Frandics P Chan, Dominik Fleischmann, Jennifer A Tremmel, Hans-Christoph Becker
BACKGROUND: Myocardial bridges (MB) are commonly seen on coronary CT angiography (CCTA) in asymptomatic individuals, but in patients with recurrent typical angina symptoms, yet no obstructive coronary artery disease (CAD), evaluation of their potential hemodynamic significance is clinically relevant. The aim of this study was to compare CCTA to invasive coronary angiography (ICA), including intravascular ultrasound (IVUS), to confirm MB morphology and estimate their functional significance in symptomatic patients...
July 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28681649/first-experience-with-multiple-mini-interview-for-medical-school-admission-in-brazil-does-it-work-in-a-different-cultural-scenario
#4
Durval Anibal Daniel-Filho, Elda Maria Stafuzza Gonçalves Pires, Angela Tavares Paes, Eduardo Juan Troster, Simone Cristina Azevedo B S Silva, Mariana Fachini Granato, Thomaz Bittencourt Couto, Joyce Kelly Silva Barreto, Alexandre Holthausen Campos, Julio C Martins Monte, Claudio Schvartsman
PURPOSE: Evaluation of non-cognitive skills never has been used in Brazil. This study aims to evaluate Multiple Mini Interviews (MMI) in the admission process of a School of Medicine in São Paulo, Brazil. METHODS: The population of the study comprised 240 applicants summoned for the interviews, and 96 raters. MMI contributed to 25% of the applicants' final grade. Eight scenarios were created with the aim of evaluating different non-cognitive skills, each one had two raters...
July 6, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28671971/effects-of-methimazole-and-propylthiouracil-exposure-during-pregnancy-on-the-risk-of-neonatal-congenital-malformations-a-meta-analysis
#5
Rongjing Song, Hepu Lin, Yue Chen, Xiuying Zhang, Wanyu Feng
OBJECTIVE: The aim of this study was to determine the effect of exposure to different antithyroid drugs during pregnancy on the incidence of neonatal congenital malformations. METHODS: A meta-analysis was performed to compare the incidence of neonatal congenital malformations after exposure to different antithyroid drugs during pregnancy. Twelve studies that met the inclusion criteria were included in this meta-analysis. PubMed, Embase, and CENTRAL databases were searched from inception until January 2017...
2017: PloS One
https://www.readbyqxmd.com/read/28657226/factors-associated-with-survival-after-relapse-in-patients-with-low-risk-endometrial-cancer-treated-with-surgery-alone
#6
Nazli Topfedaisi Ozkan, Mehmet Mutlu Meydanlı, Mustafa Erkan Sarı, Fuat Demirkiran, Ilker Kahramanoglu, Tugan Bese, Macit Arvas, Hanifi Şahin, Ali Haberal, Husnu Celik, Gonca Coban, Tufan Oge, Omer Tarik Yalcin, Özgür Akbayır, Baki Erdem, Ceyhun Numanoğlu, Nejat Özgül, Gökhan Boyraz, Mehmet Coşkun Salman, Kunter Yüce, Murat Dede, Mufit Cemal Yenen, Salih Taşkın, Duygu Altın, Uğur Fırat Ortaç, Hülya Aydın Ayık, Tayup Şimşek, Tayfun Güngör, Kemal Güngördük, Muzaffer Sancı, Ali Ayhan
OBJECTIVE: To determine factors influencing overall survival following recurrence (OSFR) in women with low-risk endometrial cancer (EC) treated with surgery alone. METHODS: A multicenter, retrospective department database review was performed to identify patients with recurrent "low-risk EC" (patients having less than 50% myometrial invasion [MMI] with grade 1 or 2 endometrioid EC) at 10 gynecologic oncology centers in Turkey. Demographic, clinicopathological, and survival data were collected...
June 16, 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28642018/clinical-study-of-27-patients-with-medial-medullary-infarction
#7
Takayoshi Akimoto, Katsuhiko Ogawa, Akihiko Morita, Yutaka Suzuki, Satoshi Kamei
BACKGROUND: Medial medullary infarction (MMI) is a rare ischemic stroke. Frequency of each neurological finding in MMI was different in each study. METHODS: We retrospectively evaluated the medical records of patients with cerebral infarction who were admitted between March 1998 and October 2015. Patients in our study were diagnosed as having MMI by magnetic resonance image examination. RESULTS: Of 2727 patients with ischemic stroke, 27 patients (20 males and 7 females) had MMI...
June 20, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28639966/risk-of-embryopathies-with-use-of-antithyroidal-medications
#8
Stine L Andersen
PURPOSE OF REVIEW: Hyperthyroidism in pregnant women should be adequately treated to prevent maternal and fetal complications. The treatment of choice in pregnancy is antithyroidal medications (ATDs). The risk of embryopathies associated with the use of Methimazole (MMI) and Propylthiouracil (PTU) in early pregnancy is a matter of clinical attention and concern. This review describes current evidence and how scientific findings are reflected in current clinical guidelines. RECENT FINDINGS: Embryopathies after the use of ATDs were previously mainly described in case reports and considered rare...
July 20, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28630718/ability-to-return-to-work-without-restrictions-in-workers-compensation-patients-undergoing-hip-arthroscopy
#9
Simon Lee, Gregory L Cvetanovich, Randy Mascarenhas, Thomas H Wuerz, Richard C Mather, Charles A Bush-Joseph, Shane J Nho
The purpose of this study was to investigate the ability of worker's compensation (WC) patients to return to work without restrictions after hip arthroscopy. Twenty-nine WC patients along with age and gender matched controls who underwent hip arthroscopy were retrospectively reviewed after achieving maximum medical improvement (MMI) status at minimum 1 year postoperatively. Patient demographic factors were evaluated, along with the Hip Outcome Score Activities of Daily Living and Sports-Specific subscales, and the modified Harris Hip Score (mHHS)...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28623911/moderate-mental-illness-as-a-predictor-of-chronic-disease-prevention-and-screening
#10
Ginetta Salvalaggio, Christopher Meaney, Rahim Moineddin, Eva Grunfeld, Donna Manca
BACKGROUND: Primary care plays a pivotal role in the provision of both mental health care and chronic disease prevention and screening (CDPS). Unfortunately, moderate mental illness (MMI) is associated with poorer general health outcomes. Part of this burden of illness may be due to reduced CDPS uptake. The Building on the Existing Tools to Improve Chronic Disease Prevention in Primary Care (BETTER) trial recruited 777 participants ages 40-65 from 32 family practice panels, of whom 135 (18...
June 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28608527/perfect-storm-therapeutic-plasma-exchange-for-a-patient-with-thyroid-storm
#11
Andrea M McGonigle, Aaron A R Tobian, Jennifer L Zink, Karen E King
Thyroid storm is a potentially lethal complication of hyperthyroidism with increased thyroid hormones and exaggerated symptoms of thyrotoxicosis. First-line therapy includes methimazole (MMI) or propylthiouracil (PTU) to block production of thyroid hormones as a bridge toward definitive surgical treatment. Untreated thyroid storm has a mortality rate of up to 30%; this is particularly alarming when patients cannot tolerate or fail pharmacotherapy, especially if they cannot undergo thyroidectomy. Therapeutic plasma exchange (TPE) is an ASFA category III indication for thyroid storm, meaning the optimum role of this therapy is not established, and there are a limited number of cases in the literature...
June 13, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28604451/is-tumor-size-really-important-for-prediction-of-lymphatic-dissemination-in-grade-1-endometrial-carcinoma-with-superficial-myometrial-invasion
#12
Murat Oz, Vakkas Korkmaz, Mehmet Mutlu Meydanli, Mustafa Erkan Sari, Zeliha Firat Cuylan, Tayfun Gungor
OBJECTIVES: Selection of patients with endometrioid endometrial cancer (EEC), in whom systematic lymph node dissection (LND) is indicated, is an important part of management to maintain optimal oncological outcomes, while avoiding unnecessary morbidities. According to the current approach, LND is recommended for the patients with International Federation of Gynecology and Obstetrics (FIGO) grade 1 to 2 tumors and a primary tumor diameter (PTD) greater than 2 cm, even with myometrial invasion (MMI) of less than 50%...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28601913/the-effects-of-a-non-cognitive-versus-cognitive-admission-procedure-within-cohorts-in-one-medical-school
#13
Marieke de Visser, Cornelia Fluit, Janke Cohen-Schotanus, Roland Laan
In medical school selection, non-cognitive performance in particular correlates with performance in clinical practice. It is arguable, therefore, that selection should focus on non-cognitive aspects despite the predictive value of prior cognitive performance for early medical school performance. The aim of this study at Radboud University Medical Center, the Netherlands, is to determine the effects of admitting students through an autonomous non-cognitive procedure on early medical school performance. We compared their performance to the performance of students selected through an autonomous cognitive selection procedure, enrolling in the Bachelor's curriculum simultaneously...
June 10, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/28593372/simultaneous-determination-of-dechloranes-polybrominated-diphenyl-ethers-and-novel-brominated-flame-retardants-in-food-and-serum
#14
Carlos Sales, Giulia Poma, Govindan Malarvannan, Tania Portolés, Joaquin Beltrán, Adrian Covaci
A sensitive method for the simultaneous quantification of dechloranes, polybrominated diphenyl ethers (PBDEs) and novel brominated flame retardants (NBFRs) has been developed for gas chromatography (GC) coupled to tandem mass spectrometry operating in electron capture negative ionization (ECNI) mode. The major advance has been achieved by combining selected ion monitoring (SIM) and multiple reaction monitoring (MRM) modes in well-defined time windows, to determine dechloranes, PBDEs and NBFRs at picogram per gram level in one single analysis in complex matrix biological samples...
June 8, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28580650/maternal-near-misses-at-a-provincial-hospital-in-papua-new-guinea-a-prospective-observational-study
#15
John W Bolnga, Marilyn Morris, Catherine Totona, Moses Laman
BACKGROUND: Maternal near-miss indices are World Health Organisation (WHO) recognised indicators that may improve our understanding of factors associated with maternal morbidity and mortality. In Papua New Guinea (PNG) where maternal mortality is among the highest in the world, only one study has documented near-miss indices in a tertiary-level hospital, but none from provincial hospitals where the majority of under-privileged women access healthcare services. AIMS: To determine the near-miss ratio, maternal mortality index (MMI), and associated maternal indices for Modilon Hospital in Madang Province of PNG...
June 5, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28574385/-connective-tissue-metabolic-features-in-climacteric-syndrome-s-patients-with-various-types-of-menopause
#16
O Gryshchenko, I Vasylieva, K Gryshchuk
The purpose of the study was investigation of the connective tissue metabolic features among women with menopausal syndrome (MS) and MS, in which the arthropathic syndrome is leading and comparative analysis of the connective tissue indicators exchange during menopause caused in a surgical and natural way. We examined 70 women in total, menopause duration they accounted for 1,95±1,1 years, it came both as natural, and as a result of a surgery. The main group included 40 women with MS with leading arthropathic syndrome...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28557950/are-female-applicants-rated-higher-than-males-on-the-multiple-mini-interview-findings-from-the-university-of-calgary
#17
Marshall Ross, Ian Walker, Lara Cooke, Maitreyi Raman, Pietro Ravani, Sylvain Coderre, Kevin McLaughlin
PURPOSE: The multiple mini-interview (MMI) improves reliability and validity of medical school interviews, and many schools have introduced this in an attempt to select individuals more skilled in communication, critical thinking, and ethical decision making. But every change in the admissions process may produce unintended consequences, such as changing intake demographics. In this article, two studies exploring gender differences in MMI ratings are reported. METHOD: Cumulative meta-analysis was used to compare MMI ratings for female and male applicants to the University of Calgary Cumming School of Medicine between 2010 and 2014...
June 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28541637/prognostic-factors-and-treatment-outcomes-in-surgically-staged-non-invasive-uterine-clear-cell-carcinoma-a-turkish-gynecologic-oncology-group-study
#18
Mustafa Erkan Sarı, Mehmet Mutlu Meydanlı, Osman Türkmen, Günsü Kimyon Cömert, Ahmet Taner Turan, Alper Karalök, Hanifi Şahin, Ali Haberal, Eda Kocaman, Özgür Akbayır, Baki Erdem, Ceyhun Numanoğlu, Kemal Güngördük, Muzaffer Sancı, Mehmet Gökçü, Nejat Özgül, Mehmet Coşkun Salman, Gökhan Boyraz, Kunter Yüce, Tayfun Güngör, Salih Taşkın, Duygun Altın, Uğur Fırat Ortaç, Hülya Aydın Ayık, Tayup Şimşek, Macit Arvas, Ali Ayhan
OBJECTIVE: To assess the prognosis of surgically-staged non-invasive uterine clear cell carcinoma (UCCC), and to determine the role of adjuvant therapy. METHODS: A multicenter, retrospective department database review was performed to identify patients with UCCC who underwent surgical treatment between 1997 and 2016 at 8 Gynecologic Oncology Centers. Demographic, clinicopathological, and survival data were collected. RESULTS: A total of 232 women with UCCC were identified...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28531955/influence-of-sediment-chemistry-and-sediment-toxicity-on-macroinvertebrate-communities-across-99-wadable-streams-of-the-midwestern-usa
#19
Patrick W Moran, Lisa H Nowell, Nile E Kemble, Barbara J Mahler, Ian R Waite, Peter C Van Metre
Simultaneous assessment of sediment chemistry, sediment toxicity, and macroinvertebrate communities can provide multiple lines of evidence when investigating relations between sediment contaminants and ecological degradation. These three measures were evaluated at 99 wadable stream sites across 11 states in the Midwestern United States during the summer of 2013 to assess sediment pollution across a large agricultural landscape. This evaluation considers an extensive suite of sediment chemistry totaling 274 analytes (polycyclic aromatic hydrocarbons, organochlorine compounds, polychlorinated biphenyls, polybrominated diphenyl ethers, trace elements, and current-use pesticides) and a mixture assessment based on the ratios of detected compounds to available effects-based benchmarks...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28504765/thermo-optic-characteristic-of-dna-thin-solid-film-and-its-application-as-a-biocompatible-optical-fiber-temperature-sensor
#20
Seongjin Hong, Woohyun Jung, Tavakol Nazari, Sanggwon Song, Taeoh Kim, Chai Quan, Kyunghwan Oh
We report unique thermo-optical characteristics of DNA-Cetyl tri-methyl ammonium (DNA-CTMA) thin solid film with a large negative thermo-optical coefficient of -3.4×10<sup>-4</sup>/°C in the temperature range from 20°C to 70°C without any observable thermal hysteresis. By combining this thermo-optic DNA film and fiber optic multimode interference (MMI) device, we experimentally demonstrated a highly sensitive compact temperature sensor with a large spectral shift of 0.15 nm/°C. The fiber optic MMI device was a concatenated structure with single-mode fiber (SMF)-coreless silica fiber (CSF)-single mode fiber (SMF) and the DNA-CTMA film was deposited on the CSF...
May 15, 2017: Optics Letters
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