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M Leo, L Bartalena, G Rotondo Dottore, E Piantanida, P Premoli, I Ionni, M Di Cera, E Masiello, L Sassi, M L Tanda, F Latrofa, P Vitti, C Marcocci, M Marinò
OBJECTIVE: In spite of previous conflicting results, an adjuvant role of selenium in the treatment of Graves' disease (GD) hyperthyroidism has been proposed. To address this issue, a randomized clinical trial was carried out aimed at investigating whether selenium is beneficial on the short-term control of GD hyperthyroidism treated with methimazole (MMI). METHODS: Thirty newly diagnosed hyperthyroid GD patients were randomly assigned to treatment with: (i) MMI or (ii) MMI plus selenium...
October 12, 2016: Journal of Endocrinological Investigation
Sang-Beom Jeon, Sun U Kwon, Jung Cheol Park, Deok Hee Lee, Sung-Cheol Yun, Yeon-Jung Kim, Jae-Sung Ahn, Byung-Duk Kwun, Dong-Wha Kang, H Alex Choi, Kiwon Lee, Jong S Kim
BACKGROUND AND PURPOSE: Hemicraniectomy is a decompressive surgery used to remove a large bone flap to allow edematous brain tissue to bulge extracranially. However, early indicators of the decompressive effects of hemicraniectomy are unclear. We investigated whether reduction of midline shift following hemicraniectomy is associated with improved consciousness and survival in patients with malignant middle cerebral artery infarctions. METHODS: We studied 70 patients with malignant middle cerebral artery infarctions (MMI) who underwent hemicraniectomies...
September 2016: Journal of Stroke
Marenza Leo, Teresa Mautone, Ilaria Ionni, Maria Antonietta Profilo, Elena Sabini, Francesca Menconi, Barbara Mazzi, Roberto Rocchi, Francesco Latrofa, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò
OBJECTIVE: Intravenous (iv) glucocorticoids (GC) (ivGC) are used for active Graves orbitopathy (GO), but factors affecting GO outcome are poorly understood. We performed a retrospective study to investigate the variables affecting GO after ivGC. METHODS: We evaluated 83 consecutive GO patients treated with ivGC but not orbital radiotherapy (ORT) and re-examined them after a median of 47 months. The endpoints were the relationships between GO outcome or additional treatments with age, sex, smoking habits, thyroid volume, thyroid treatment, time since thyroid treatment, antithyroid-stimulating hormone receptor antibodies (TRAb), GO duration, GO features, and follow-up time...
October 2016: Endocrine Practice
Mengyi Liu, Shiguang Shan, Ruiping Wang, Xilin Chen
Facial expression is a temporally dynamic event which can be decomposed into a set of muscle motions occurring in different facial regions over various time intervals. For dynamic expression recognition, two key issues, temporal alignment and semantics-aware dynamic representation, must be taken into account. In this paper, we attempt to solve both problems via manifold modeling of videos based on a novel midlevel representation, i.e. expressionlet. Specifically, our method contains three key stages: 1) each expression video clip is characterized as a spatial-temporal manifold (STM) formed by dense low-level features; 2) a Universal Manifold Model (UMM) is learned over all low-level features and represented as a set of local modes to statistically unify all the STMs...
October 5, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Nozomi Okamoto, Masayuki Morikawa, Nobuko Amano, Motokazu Yanagi, Shin Takasawa, Norio Kurumatani
BACKGROUND: Several studies have suggested that periodontal disease can exacerbate the pro-inflammatory status of the brain. Tooth loss is one of the alternative evaluation indices of periodontal disease. There are few data on the relationship between tooth loss and memory impairment, depending on the apolipoprotein E (APOE) ɛ4 genotype. OBJECTIVE: To determine if tooth loss is associated with mild memory impairment (MMI) and if this association is modified by the presence of the APOEɛ4 allele...
October 1, 2016: Journal of Alzheimer's Disease: JAD
Yijie Ding, Jijun Tang, Fei Guo
BACKGROUND: Protein-protein interactions (PPIs) are central to a lot of biological processes. Many algorithms and methods have been developed to predict PPIs and protein interaction networks. However, the application of most existing methods is limited since they are difficult to compute and rely on a large number of homologous proteins and interaction marks of protein partners. In this paper, we propose a novel sequence-based approach with multivariate mutual information (MMI) of protein feature representation, for predicting PPIs via Random Forest (RF)...
September 27, 2016: BMC Bioinformatics
Kevin Cowart, Kamila Dell, Nazach Rodriguez-Snapp, Heather M W Petrelli
Objective. To investigate the correlation of mean admission multiple mini-interview (MMI) scores with cumulative and overall GPA across didactic years 1-3 in the doctor of pharmacy (PharmD) curriculum. Methods. The mean admission MMI score and cumulative and overall GPA for first year (P1), second year (P2), and third year (P3) students in the PharmD curriculum was used to conduct a multiple regression analysis and to calculate a Pearson correlation coefficient. Statistical analysis was performed using SPSS, v20...
August 25, 2016: American Journal of Pharmaceutical Education
Marcus Antonius Ynalvez, Ruby A Ynalvez, Enrique Ramírez
We explored the social shaping of science at the micro-level reality of face-to-face interaction in one of the traditional places for scientific activities-the scientific lab. We specifically examined how doctoral students' perception of their: (i) interaction with doctoral mentors (MMI) and (ii) lab social environment (LSE) influenced productivity. Construed as the production of peer-reviewed articles, we measured productivity using total number of articles (TOTAL), number of articles with impact factor greater than or equal to 4...
September 26, 2016: Biochemistry and Molecular Biology Education
Junxia Cui, Qing Chu, Tianjun Xu
Innate and acquired immune responses provide critical line in defense against pathogens. MicroRNAs (miRNAs) play crucial roles in regulate gene expression in inflammation and innate immunity. However, the main role of miRNAs are in a large part unclear in aquatic organisms. In this study, we found that miR-122 displayed dramatically declined expression profiles in Vibrio anguillarum challenged miiuy croaker. Meanwhile, we have explored TLR14 as a novel target gene of miR-122 involved in miiuy croakers inflammatory and immune response, which were further estimated through negative expression profiles in both Vibrio anguillarum challenged miiuy croaker and LPS exposure macrophages...
September 13, 2016: Fish & Shellfish Immunology
Ying Peng, Yicheng Qi, Fengjiao Huang, Xinxin Chen, Yulin Zhou, Lei Ye, Weiqing Wang, Guang Ning, Shu Wang
Resistin, belongs to cysteine-rich secretory protein, is mainly produced by circulating leukocytes, such as neutrophils monocytes and macrophages in humans. To date, few but controversial studies have reported about resistin concentrations in hyperthyroid patients, especially in Graves' disease (GD). We undertaked a controlled, prospective study to explore the serum resistin concentration in GD patients before and after -MMI treatment. In addition, we also investigated the main influencing factor on serum resistin level and discuessed the potential role of serum resistin plays in GD patients...
September 14, 2016: Oncotarget
Volha Kistsen, Victor Evstigneev, Boris Dubovik, Vladimir Ulashchik
BACKGROUND: Clinical and experimental results show that repetitive transcranial magnetic stimulation (rTMS) is effective and safe in the treatment of epilepsy. The characteristics of the impulse magnetic field (IMF) are empirical in these studies, making impossible to compare their effectiveness. OBJECTIVES: The article presents the results of a study of the anticonvulsive effects of different modes of IMF on the picrotoxin seizure model, which is important for studying GABAergic brain mechanisms activated by rTMS...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Parya Samadian, Trevor Hall
Tapered multimode interference (MMI) couplers have been broadly studied for applications in integrated photonic circuits due to their footprints being smaller than conventional MMIs. The operation of an MMI is fundamentally related to the Talbot effect. In this Letter, the Talbot effect is analyzed in cylindrical coordinates, rather than conventional Cartesian coordinates. A cylindrical geometry is found to result in a significant reduction of Talbot distance and, hence, more compact MMIs. Simulation results are compared to theoretical predictions to confirm the accuracy of the method...
September 1, 2016: Optics Letters
Vidya Puthenpura, Kinjal Desai, Andrew Bauer, Ian Marshall
BACKGROUND: Agranulocytosis is regarded as a rare side effect of methimazole (MMI) therapy that occurs in a dose dependent manner and that usually develops within the first 3-6 months of treatment. Although delayed development beyond this timeline has been documented in adults, very few children have been reported with this presentation. CASE PRESENTATION: We present a 6-year old patient who developed agranulocytosis 18 months after the start of MMI therapy. CONCLUSIONS: This is an unusual case of a 6-year old patient who developed this serious side effect on stable MMI therapy well beyond the typical timeline...
2016: International Journal of Pediatric Endocrinology
Ely Kosnicki, Stephen A Sefick, Michael H Paller, Miller S Jerrell, Blair A Prusha, Sean C Sterrett, Tracey D Tuberville, Jack W Feminella
A macroinvertebrate multimetric index is an effective tool for assessing the biological integrity of streams. However, data collected under a single protocol may not be available for an entire region. We sampled macroinvertebrates from the full extent of the Sand Hills ecoregion Level IV of the Southeastern Plains with a standard protocol during the summers of 2010-2012. We evaluated the performance of 94 metrics through a series of screening criteria and built 48 macroinvertebrate multimetric indexs with combinations of the best performing metrics, representing richness, habit, functional feeding guild, sensitivity, and community composition...
October 2016: Environmental Management
Bartosz Hudzik, Barbara Zubelewicz-Szkodzinska
Antithyroid drugs (ATD) are widely used for the treatment of Graves' disease (GD) in the general population. Over the past decade there has been an increasing awareness that several disturbances of thyroid function may occur in mothers after delivery which may be more prevalent than previously appreciated. Exacerbation of immune reactions occurs 3-12 month following delivery. Management of hyperthyroidism during lactation requires special considerations and should be implemented to prevent any adverse outcomes in mother and neonate...
August 26, 2016: Clinical Endocrinology
Helena Rakov, Kathrin Engels, Georg Sebastian Hönes, Karl-Heinz Strucksberg, Lars Christian Moeller, Josef Köhrle, Denise Zwanziger, Dagmar Führer
BACKGROUND: Thyroid dysfunction is more common in the female population, however, the impact of sex on disease characteristics has rarely been addressed. Using a murine model, we asked whether sex has an influence on phenotypes, thyroid hormone status, and thyroid hormone tissue response in hyper- and hypothyroidism. METHODS: Hypo- and hyperthyroidism were induced in 5-month-old female and male wildtype C57BL/6N mice, by LoI/MMI/ClO4 (-) or T4 i.p. treatment over 7 weeks, and control animals underwent sham treatment (N = 8 animals/sex/treatment)...
2016: Biology of Sex Differences
Nikki L Bibler Zaidi, Christopher M Swoboda, Benjamin M Kelcey, R Stephen Manuel
The extant literature has largely ignored a potentially significant source of variance in multiple mini-interview (MMI) scores by "hiding" the variance attributable to the sample of attributes used on an evaluation form. This potential source of hidden variance can be defined as rating items, which typically comprise an MMI evaluation form. Due to its multi-faceted, repeated measures format, reliability for the MMI has been primarily evaluated using generalizability (G) theory. A key assumption of G theory is that G studies model the most important sources of variance to which a researcher plans to generalize...
August 20, 2016: Advances in Health Sciences Education: Theory and Practice
Lingyan Zhou, Shuyan Ding, Yujie Li, Laicheng Wang, Wenbin Chen, Tao Bo, Kunpeng Wu, Congcong Li, Xiaojing Liu, Jiajun Zhao, Chao Xu, Ling Gao
Subclinical hypothyroidism (SCH) is becoming a global health problem due to its increasing prevalence and potential deleterious effects. However, the molecular mechanisms underlying the lipid metabolic disorders in SCH have not been fully clarified. Additionally, progress in elucidating the exact pathogenesis of SCH has been hampered by the lack of optimized mouse models. Methimazole (MMI) was applied to construct a noninvasive SCH mouse model. Eight-week-old C57BL/6 mice were administrated MMI through the drinking water...
2016: Scientific Reports
Roberto Negro, Roberto Attanasio, Franco Grimaldi, Rinaldo Guglielmi, Enrico Papini
BACKGROUND: Patients suffering from Graves' disease (GD) are quite frequent in endocrine clinical practice. In particular, overt hyperthyroidism may be complicated by serious adverse events and requires careful treatment, but its management has changed over the years in both the USA and European Union (EU). OBJECTIVES: To evaluate the current diagnosis and management of patient's with GD in Italy, and compare results with those obtained in previous similar surveys in the USA and EU...
July 2016: European Thyroid Journal
Xinzi Wang, Xiaohui Zhao, Hanbing Li, Jianli Jia, Yueqiao Liu, Odafe Ejenavi, Aizhong Ding, Yujiao Sun, Dayi Zhang
Uncultivable microorganisms account for over 99% of all species on the planet, but their functions are yet not well characterized. Though many cultivable degraders for n-alkanes have been intensively investigated, the roles of functional n-alkane degraders remain hidden in the natural environment. This study introduces the novel magnetic nanoparticle-mediated isolation (MMI) technology in Nigerian soils and successfully separates functional microbes belonging to the families Oxalobacteraceae and Moraxellaceae, which were dominant and responsible for alkane metabolism in situ...
July 27, 2016: Research in Microbiology
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