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Thalía Domínguez Bucio, Ali Z Khokhar, Goran Z Mashanovich, Frederic Y Gardes
We report the design and fabrication of a compact angled multimode interferometer (AMMI) on a 600 nm thick N-rich silicon nitride platform (n=1.92) optimized to match the International Telecommunication Union coarse wavelength division (de)multiplexing standard in the O telecommunication band. The demonstrated device exhibited a good spectral response with Δλ=20  nm, BW3 dB ∼11  nm, IL<1.5  dB, and XT∼20  dB. Additionally, it showed a high tolerance to dimensional errors <120  pm/nm and low sensitivity to temperature variations <20  pm/°C, respectively...
March 15, 2018: Optics Letters
Zeliha F Cuylan, Murat Oz, Nazli T Ozkan, Gunsu K Comert, Hanifi Sahin, Taner Turan, Ozgur Akbayir, Esra Kuscu, Husnu Celik, Murat Dede, Tayfun Gungor, Mehmet M Meydanli, Ali Ayhan
AIM: The purpose of this study was to determine the prognostic factors and patterns of failure in lymphovascular space invasion (LVSI)-positive women with stage IIIC endometrioid endometrial cancer (EC). METHODS: A multicenter, retrospective, department database review was performed to identify LVSI-positive patients with stage IIIC endometrioid EC at five gynecological oncology centers in Turkey. Demographic, clinicopathological and survival data were collected...
March 8, 2018: Journal of Obstetrics and Gynaecology Research
Barbara Seebacher, Raija Kuisma, Angela Glynn, Thomas Berger
Background: Motor imagery (MI) is increasingly used in neurorehabilitation to facilitate motor performance. Our previous study results demonstrated significantly improved walking after rhythmic-cued MI in people with multiple sclerosis (pwMS). The present feasibility study was aimed to obtain preliminary information of changes in walking, fatigue, quality of life (QoL) and MI ability following cued and non-cued MI in pwMS. The study further investigated the feasibility of a larger study and examined the reliability of a two-dimensional gait analysis system...
2018: Archives of Physiotherapy
Anthony Jerant, Mark C Henderson, Erin Griffin, Efrain Talamantes, Tonya Fancher, Francis Sousa, Peter Franks
Multiple Mini-Interviews (MMIs) are increasingly used in medical school admissions. We previously reported that while under-represented minority (URM) status was not associated with MMI scores, self-designated disadvantaged applicants had lower MMI scores, possibly affecting their matriculation prospects. No studies have examined how URM status or socioeconomic disadvantage (SED) are associated with academic performance following admission through an MMI. We examined the adjusted associations of MMI scores, SED, and URM status with U...
2018: Journal of Health Care for the Poor and Underserved
Nan Zhou, Shuang Zheng, Yun Long, Zhengsen Ruan, Li Shen, Jian Wang
We propose and demonstrate a reconfigurable and tunable chip-scale comb filter and (de)interleaver on a silicon platform. The silicon-based photonic integrated device is formed by Sagnac loop mirrors (SLMs) with directional couplers replaced by multi-mode interference (MMI) assisted tunable Mach-Zehnder interferometer (MZI) couplers. The device can be regarded as a large SLM incorporating two small SLMs which form a Fabry-Perot (FP) cavity. By appropriately adjusting the micro-heaters in tunable MZI couplers and cavity, switchable operation between comb filter and (de)interleaver and extinction ratio and wavelength tunable operations of comb filter and (de)interleaver are achievable by thermo-optic tuning...
February 19, 2018: Optics Express
Fernanda Maria Martins, Aletéia de Paula Souza, Paulo Ricardo Prado Nunes, Márcia Antoniazi Michelin, Eddie Fernando Candido Murta, Elisabete Aparecida Mantovani Rodrigues Resende, Erick Prado de Oliveira, Fábio Lera Orsatti
OBJECTIVE: This study compared the effects of 12 weeks of high-intensity interval body weight training (HIBWT) with combined training (COMT; aerobic and resistance exercises on body composition, a 6-minute walk test (6MWT; physical performance), insulin resistance (IR) and inflammatory markers in postmenopausal women (PW) at high risk of type 2 diabetes mellitus (TDM2). METHODS: In this randomized controlled clinical study, 16 PW at high risk of TDM2 were randomly allocated into two groups: HIBWT (n = 8) and COMT (n = 8)...
February 19, 2018: Experimental Gerontology
Yukio Ochi, Takashi Hachiya, Yukiko Koyama, Nobutoshi Fukuhori, Noriyuki Ashida
The effect of antithyroid drugs(ATDs)[methylmercaptoimidazole (MMI) and propylthiouracil (PTU)] and reducing agents (mercaptoethanol, dithiothreitol and cysteine) on bovine (b) TSH binding to human (h) and porcine (p) TSH receptor (R) was examined. (1) ATDs was pre-incubated with hTSHR coated tube for 1- 4 h, washed free of ATDs, and then 125I-bTSH binding to hTSHR after 1 h incubation was examined. MMI (10-40 mM) decreased 125I-bTSH binding in a dose-dependent manner and binding decreased proportionally as pre-incubation time increased from 1 to 4 h...
February 19, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Ricardo N Alves, Kristina S Sundell, Liliana Anjos, Henrik Sundh, Torstein Harboe, Birgitta Norberg, Deborah M Power
To establish if the developmental changes in the primary barrier and osmoregulatory capacity of Atlantic halibut skin are modified during metamorphosis, histological, histochemical, gene expression and electrophysiological measurements were made. The morphology of the ocular and abocular skin started to diverge during the metamorphic climax and ocular skin appeared thicker and more stratified. Neutral mucins were the main glycoproteins produced by the goblet cells in skin during metamorphosis. Moreover, the number of goblet cells producing neutral mucins increased during metamorphosis and asymmetry in their abundance was observed between ocular and abocular skin...
February 20, 2018: Cell and Tissue Research
Alison Callwood, Kamalan Jeevaratnam, Grigorios Kotronoulas, Annegret Schneider, Liane Lewis, Vishna Devi Nadarajah
OBJECTIVES: To examine the personal domains multiple mini interviews (MMIs) are being designed to assess, explore how they were determined and contextualise such domains in current and future healthcare student selection processes DESIGN: A systematic review of empirical research reporting on MMI model design was conducted from database inception to November 2017. DATA SOURCES: Twelve electronic bibliographic databases. REVIEW METHODS: Evidence was extracted from original studies, and integrated in a narrative synthesis guided by the PRISMA statement for reporting systematic reviews...
January 31, 2018: Nurse Education Today
Carol A Terregino, H Liesel Copeland, Sonia Garcia Laumbach, Daniel Mehan, Dana Dunleavy, Thomas Geiger
BACKGROUND: Can a locally developed multiple mini interview (MMI) process lead to outcomes reflective of local values and mission? METHODS: In 2017, the authors performed a retrospective analysis of the relationship of MMI with multiple-choice-based outcomes and non-multiple-choice-based outcomes, including clerkship competencies, OSCE, scholarship/service/leadership, academic honor society induction, peer and faculty humanism nominations, and overall performance at graduation for two entering classes with acceptance decisions based exclusively on a locally developed MMI...
February 19, 2018: Medical Teacher
Kenichi Kawahori, Koshi Hashimoto, Xunmei Yuan, Kazutaka Tsujimoto, Nozomi Hanzawa, Miho Hamaguchi, Saori Kase, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Yasuyo Nakajima, Nobuyuki Shibusawa, Masanobu Yamada, Yoshihiro Ogawa
BACKGROUND: Thyroid hormones are essential for normal development of the central nervous system (CNS). Experimental rodents have shown that even a subtle thyroid hormone insufficiency in circulating maternal thyroid hormones during pregnancy may adversely affect neurodevelopment in offspring, resulting in irreversible cognitive deficits. This may be due to the persistent reduced expression of the hippocampal brain-derived neurotrophic factor gene (Bdnf), which plays a crucial role in CNS development...
February 7, 2018: Thyroid: Official Journal of the American Thyroid Association
Ye Tian, Jifang Qiu, Zhuili Huang, Yingying Qiao, Zhenli Dong, Jian Wu
We propose a novel all-optical phase shifted quantizer using cascade step-size MMI. The operation principle has been derived in detail. A 3-bit quantizer and a 5-bit quantizer are designed and simulated based on 220-nm SOI platform to verify the feasibility of the scheme, of which the lengths are all below 200 μm. To the best of our knowledge, they have the most compact footprint compared to the existing all-optical quantizers. In the end, the fabrication error analyses of the proposed quantizers are carried out to verify their stability...
February 5, 2018: Optics Express
Bo Jiang, Naifu Jin, Yi Xing, Yuping Su, Dayi Zhang
Uncultivable microorganisms account for over 99% of all species on earth, playing essential roles in ecological processes such as carbon/nitrogen cycle and chemical mineralization. Their functions remain unclear in ecosystems and natural habitats, requiring cutting-edge biotechnologies for a deeper understanding. Stable isotope probing (SIP) incorporates isotope-labeled elements, e.g. 13 C, 18 O or 15 N, into the cellular components of active microorganisms, serving as a powerful tool to link phylogenetic identities to their ecological functions in situ...
February 1, 2018: Critical Reviews in Biotechnology
Kevin W Eva, Catherine Macala, Bruce Fleming
Health professions the world over value various competencies in their practitioners that are not easily captured by academic measures of performance. As a result, many programs have begun using multiple mini-interviews (MMIs) to facilitate the selection of candidates who are most likely to demonstrate and further develop such qualities. In this twelve-tips article, the authors offer evidence- and experience-based advice regarding how to construct an MMI that is fit for purpose. The tips are provided chronologically, offering guidance regarding how one might conceptualize their goals for creating an MMI, how to establish a database of stations that are context appropriate, and how to prepare both candidates and examiners for their task...
January 26, 2018: Medical Teacher
Annette Burgess, Chris Roberts, Premala Sureshkumar, Karyn Mossman
BACKGROUND: Multiple Mini Interviews (MMIs) are being used by a growing number of postgraduate training programs and medical schools as their interview process for selection entry. The Australian General Practice and Training (AGPT) used a National Assessment Centre (NAC) approach to selection into General Practice (GP) Training, which include MMIs. Interviewing is a resource intensive process, and implementation of the MMI requires a large number of interviewers, with a number of candidates being interviewed simultaneously...
January 25, 2018: BMC Medical Education
Vitaly Schetinin, Livija Jakaite, Ndifreke Nyah, Dusica Novakovic, Wojtek Krzanowski
The brain activity observed on EEG electrodes is influenced by volume conduction and functional connectivity of a person performing a task. When the task is a biometric test the EEG signals represent the unique "brain print", which is defined by the functional connectivity that is represented by the interactions between electrodes, whilst the conduction components cause trivial correlations. Orthogonalization using autoregressive modeling minimizes the conduction components, and then the residuals are related to features correlated with the functional connectivity...
December 28, 2017: International Journal of Neural Systems
Hüseyin Göksülük, Yusuf Atmaca, Menekşe Gerede Uludağ, Cansın Tulunay Kaya, Onur Yıldırım, Müge Akbulut, Nil Özyüncü, Cetin Erol
BACKGROUND: Elective percutaneous coronary intervention (ePCI) may cause minor elevation of cardiac enzymes, so-called minor myocardial injury (MMI) which can be due to different pathophysiological mechanism (e.g. distal embolisation, side branch occlusion, increased platelet activation triggered by the intracoronary metallic stents). We aimed to compare the effectiveness of ticagrelor versus clopidogrel for the prevention of MMI and major adverse clinical events (MACEs) after ePCI. METHODS: Study population consisted of two groups of patients based on the treatment: Group I, receiving clopidogrel (n = 104), Group II, receiving ticagrelor (n = 96)...
January 22, 2018: Acta Cardiologica
Gi Hyeon Seo, Tae Hyuk Kim, Jae Hoon Chung
Background: Untreated or insufficiently treated Graves disease in pregnancy may pose risks to both mother and fetus. Antithyroid drugs (ATDs) are the treatment mainstay, but the potential teratogenic effect of these drugs has prompted clinicians to question the safe management of this vulnerable population. Objective: To examine the association between maternal prescriptions for ATDs and congenital malformations in live births. Design: Nationwide cohort study...
January 23, 2018: Annals of Internal Medicine
Marco Messina, James Njuguna, Chrysovalantis Palas
This work focuses on the proof-mass mechanical structural design improvement of a tri-axial piezoresistive accelerometer specifically designed for head injuries monitoring where medium-G impacts are common; for example, in sports such as racing cars or American Football. The device requires the highest sensitivity achievable with a single proof-mass approach, and a very low error (<1%) as the accuracy for these types of applications is paramount. The optimization method differs from previous work as it is based on the progressive increment of the sensor proof-mass mass moment of inertia (MMI) in all three axes...
January 19, 2018: Sensors
Fernando Gomez-Peralta, Pablo Velasco-Martínez, Cristina Abreu, María Cepeda, Marta Fernández-Puente
Methimazole (MMI) and propylthiouracil (PTU) are widely used antithyroid drugs (ATD) that have been approved for the treatment of hyperthyroidism. Hepatotoxicity may be induced by these drugs, though they exert dissimilar incidence rates of hepatotoxicity and, possibly, with different underlying pathogenic mechanisms. We report the case of a 55-year-old woman with no relevant medical history diagnosed with hyperthyroidism due to Graves' disease, who developed two episodes of acute hepatitis concurrent with the consecutive administration of two different ATDs, first MMI and then PTU...
2018: Endocrinology, Diabetes & Metabolism Case Reports
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