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https://www.readbyqxmd.com/read/29351221/mechanical-structural-design-of-a-mems-based-piezoresistive-accelerometer-for-head-injuries-monitoring-a-computational-analysis-by-increments-of-the-sensor-mass-moment-of-inertia
#1
Marco Messina, James Njuguna, Chrysovalantis Palas
This work focuses on the proof-mass mechanical structural design improvement of a tri-axial piezoresistive accelerometer specifically designed for head injuries monitoring where medium-G impacts are common; for example, in sports such as racing cars or American Football. The device requires the highest sensitivity achievable with a single proof-mass approach, and a very low error (<1%) as the accuracy for these types of applications is paramount. The optimization method differs from previous work as it is based on the progressive increment of the sensor proof-mass mass moment of inertia (MMI) in all three axes...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29340156/hepatotoxicity-in-hyperthyroid-patient-after-consecutive-methimazole-and-propylthiouracil-therapies
#2
Fernando Gomez-Peralta, Pablo Velasco-Martínez, Cristina Abreu, María Cepeda, Marta Fernández-Puente
Methimazole (MMI) and propylthiouracil (PTU) are widely used antithyroid drugs (ATD) that have been approved for the treatment of hyperthyroidism. Hepatotoxicity may be induced by these drugs, though they exert dissimilar incidence rates of hepatotoxicity and, possibly, with different underlying pathogenic mechanisms. We report the case of a 55-year-old woman with no relevant medical history diagnosed with hyperthyroidism due to Graves' disease, who developed two episodes of acute hepatitis concurrent with the consecutive administration of two different ATDs, first MMI and then PTU...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29310723/iatrogenic-creutzfeldt-jakob-disease-with-amyloid-%C3%AE-pathology-an-international-study
#3
Ignazio Cali, Mark L Cohen, Stéphane Haїk, Piero Parchi, Giorgio Giaccone, Steven J Collins, Diane Kofskey, Han Wang, Catriona A McLean, Jean-Philippe Brandel, Nicolas Privat, Véronique Sazdovitch, Charles Duyckaerts, Tetsuyuki Kitamoto, Ermias D Belay, Ryan A Maddox, Fabrizio Tagliavini, Maurizio Pocchiari, Ellen Leschek, Brian S Appleby, Jiri G Safar, Lawrence B Schonberger, Pierluigi Gambetti
The presence of pathology related to the deposition of amyloid-β (Aβ) has been recently reported in iatrogenic Creutzfeldt-Jakob disease (iCJD) acquired from inoculation of growth hormone (GH) extracted from human cadaveric pituitary gland or use of cadaveric dura mater (DM) grafts.To investigate this phenomenon further, a cohort of 27 iCJD cases - 21 with adequate number of histopathological sections - originating from Australia, France, Italy, and the Unites States, were examined by immunohistochemistry, amyloid staining, and Western blot analysis of the scrapie prion protein (PrPSc), and compared with age-group matched cases of sporadic CJD (sCJD), Alzheimer disease (AD) or free of neurodegenerative diseases (non-ND)...
January 8, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29310665/a-patient-specific-treatment-model-for-graves-hyperthyroidism
#4
Balamurugan Pandiyan, Stephen J Merrill, Flavia Di Bari, Alessandro Antonelli, Salvatore Benvenga
BACKGROUND: Graves' is disease an autoimmune disorder of the thyroid gland caused by circulating anti-thyroid receptor antibodies (TRAb) in the serum. TRAb mimics the action of thyroid stimulating hormone (TSH) and stimulates the thyroid hormone receptor (TSHR), which results in hyperthyroidism (overactive thyroid gland) and goiter. Methimazole (MMI) is used for hyperthyroidism treatment for patients with Graves' disease. METHODS: We have developed a model using a system of ordinary differential equations for hyperthyroidism treatment with MMI...
January 9, 2018: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/29306938/overview-of-systematic-reviews-of-mindfulness-meditation-based-interventions-for-people-with-long-term-conditions
#5
Jaqui Long, Michelle Briggs, Felicity Astin
Context • Increasing numbers of people worldwide live with a long-term health condition (LTC). Finding new ways to support people diagnosed with LTCs is important, both to improve their health-related quality of life and to manage the demands on health services that their conditions present. This effort includes a recognition of the importance of interventions to promote self-care. A growing number of systematic reviews of mindfulness meditation-based interventions (MMIs) for people with LTCs have been published but are diverse in scope and quality...
October 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/29306930/management-of-thyrotoxicosis-in-children-and-adolescents-35-years-experience-in-304-patients
#6
Fereidoun Azizi, Atieh Amouzegar
BACKGROUND: Diffuse toxic goiter accounts for about 15% of all childhood thyroid diseases. There is great controversy over the management of Graves' disease in children and adolescents. This article reports our experience in 304 children and juvenile patients with Graves' disease. METHODS: Between 1981 and 2015, 304 patients aged 5-19 years with diffuse toxic goiter were studied, of whom 296 patients were treated with antithyroid drugs (ATD) for 18 months. Patients with persistent or relapsed hyperthyroidism who refused ablative therapy with surgery or radioiodine were managed with continuous methimazole (MMI) treatment...
January 8, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29273081/sex-specific-phenotypes-of-hyperthyroidism-and-hypothyroidism-in-aged-mice
#7
Helena Rakov, Kathrin Engels, Georg Sebastian Hönes, Klaudia Brix, Josef Köhrle, Lars Christian Moeller, Denise Zwanziger, Dagmar Führer
BACKGROUND: Sex and age play a role in the prevalence of thyroid dysfunction (TD), but their interrelationship for manifestation of hyper- and hypothyroidism is still not well understood. Using a murine model, we asked whether sex impacts the phenotypes of hyper- and hypothyroidism at two life stages. METHODS: Hyper- and hypothyroidism were induced by i.p. T4 or MMI/ClO4-/LoI treatment over 7 weeks in 12- and 20-months-old female and male C57BL/6N mice. Control animals underwent PBS treatment (n = 7-11 animals/sex/treatment)...
December 22, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/29241957/evaluation-of-adsorption-selectivity-of-immunoglobulins-m-a-and-g-and-purification-of-immunoglobulin-m-with-mixed-mode-resins
#8
Ying-Di Luo, Qi-Lei Zhang, Shan-Jing Yao, Dong-Qiang Lin
This study investigated adsorption selectivity of immunoglobulin M (IgM), immunoglobulin A (IgA) and immunoglobulin (IgG) on four mixed-mode resins with the functional ligands of 4-mercatoethyl-pyridine (MEP), 2-mercapto-1-methylimidazole (MMI), 5-aminobenzimidazole (ABI) and tryptophan-5-aminobenzimidazole (W-ABI), respectively. IgM purification processes with mixed-mode resins were also proposed. All resins showed typical pH-dependent adsorption, and high adsorption capacity was found at pH 5.0-8.0 with low adsorption capacity under acidic conditions...
December 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29222678/dose-responses-for-mortality-from-cerebrovascular-and-heart-diseases-in-atomic-bomb-survivors-1950-2003
#9
Helmut Schöllnberger, Markus Eidemüller, Harry M Cullings, Cristoforo Simonetto, Frauke Neff, Jan Christian Kaiser
The scientific community faces important discussions on the validity of the linear no-threshold (LNT) model for radiation-associated cardiovascular diseases at low and moderate doses. In the present study, mortalities from cerebrovascular diseases (CeVD) and heart diseases from the latest data on atomic bomb survivors were analyzed. The analysis was performed with several radio-biologically motivated linear and nonlinear dose-response models. For each detrimental health outcome one set of models was identified that all fitted the data about equally well...
December 8, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29221025/sensitive-refractive-index-sensor-based-on-an-assembly-free-fiber-multi-mode-interferometer-fabricated-by-femtosecond-laser
#10
Pengcheng Chen, Xuewen Shu, Fangcheng Shen, Haoran Cao
We propose and demonstrate a highly sensitive refractive index (RI) sensor based on a novel fiber-optic multi-mode interferometer (MMI), which is formed with a femtosecond-laser-induced in-core negative refractive index modified line in a standard single mode fiber. The proposed MMI structure is directly written with femtosecond laser in one step, which removes the splicing process needed in conventional MMI fabrication and also significantly improves the robustness. This device exhibits a high sensitivity to surrounding refractive index, with a maximum sensitivity up to 10675...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29212309/imaging-cancer-metabolism
#11
REVIEW
Milica Momcilovic, David B Shackelford
It is widely accepted that altered metabolism contributes to cancer growth and has been described as a hallmark of cancer. Our view and understanding of cancer metabolism has expanded at a rapid pace, however, there remains a need to study metabolic dependencies of human cancer in vivo. Recent studies have sought to utilize multi-modality imaging (MMI) techniques in order to build a more detailed and comprehensive understanding of cancer metabolism. MMI combines several in vivo techniques that can provide complementary information related to cancer metabolism...
December 7, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29202171/the-multiple-mini-interview-a-possible-solution-to-problems-associated-with-the-interview-processes-for-a-selected-entry-allied-health-program
#12
P Y Cope, Sally Clendon, Tom Nicholson
BACKGROUND: Concerns have been raised about the effectiveness of traditional semi-structured interviews in selected entry allied health programs in terms of whether they give applicants the best opportunity to demonstrate their personal qualities and whether the process itself is overly intimidating and impersonal. This in turn raises questions about the reliability and validity of interviews. In this study, a possible alternative process was examined, the multiple mini-interview (MMI)...
2017: Journal of Allied Health
https://www.readbyqxmd.com/read/29189197/hr-pqct-detects-alterations-in-bone-microstructure-in-men-with-ckd-stages-3-and-4-which-are-influenced-by-hormonal-changes-and-body-composition%C3%A2
#13
Francisco P Paranhos-Neto, Guilherme A C Lima, Luciana C Silva, Miguel Madeira, Leonardo Vieira Neto, Laura M C Mendonça, Inayá C B Lima, Alvimar G Delgado, Maurilo Leite, Carlos P Gomes, Maria Lucia F Farias
INTRODUCTION: Factors associated with osteodystrophy in predialysis patients are poorly understood. In the present study, we attempted to evaluate the impact of body composition and hormonal regulatory factors on the bone microstructure in a group of men with chronic kidney disease (CKD) stages 3 and 4. MATERIALS AND METHODS: 46 men, aged 50 - 75 years, with previously unrecognized CKD were evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT), and dual-energy X-ray absorptiometry (DXA)...
November 30, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29177976/probability-of-misclassifying-biological-elements-in-surface-waters
#14
Małgorzata Loga, Anna Wierzchołowska-Dziedzic
Measurement uncertainties are inherent to assessment of biological indices of water bodies. The effect of these uncertainties on the probability of misclassification of ecological status is the subject of this paper. Four Monte-Carlo (M-C) models were applied to simulate the occurrence of random errors in the measurements of metrics corresponding to four biological elements of surface waters: macrophytes, phytoplankton, phytobenthos, and benthic macroinvertebrates. Long series of error-prone measurement values of these metrics, generated by M-C models, were used to identify cases in which values of any of the four biological indices lay outside of the "true" water body class, i...
November 24, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29175223/implementation-of-a-mindfulness-moment-initiative-for-healthcare-professionals-perceptions-of-facilitators
#15
Karen Duggan, Kell Julliard
CONTEXT: Mindfulness practices in the workplace have experienced rapid growth, with initial evidence suggesting positive outcomes. Even so, little is known about implementing mindfulness-based interventions (MBI), especially internally driven programs led by volunteers rather than experts. OBJECTIVE: This study qualitatively explores volunteer facilitators' perceptions of a short-dose MBI (the mindfulness moment initiative) before and 6 weeks after implementation...
November 23, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/29174305/perinatal-hypothyroidism-increases-play-behaviors-in-juvenile-rats
#16
Spencer G Smith, Katharine V Northcutt
Thyroid hormones play an instrumental role in the development of the central nervous system. During early development, the fetus is dependent on maternal thyroid hormone production due to the dysfunction of its own thyroid gland. Thus, maternal thyroid dysfunction has been shown to elicit significant abnormalities in neural development, neurochemistry, and behavior in offspring. Previous reports have suggested that human maternal hypothyroidism may increase the chances of having children with autism spectrum disorder and attention-deficit/hyperactivity disorder...
November 21, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29163843/effect-of-subclinical-hypothyroidism-on-the-skeletal-system-and-improvement-with-short-term-thyroxine-therapy
#17
Cuixia Gao, Yu Wang, Tingting Li, Jing Huang, Limin Tian
The purpose of the study was to observe changes in the skeletal system of rats with subclinical hypothyroidism (SCH) and to determine whether L-thyroxine (L-T4) administration suppresses those changes. Sixty male Wistar rats were randomly divided into control, SCH, and SCH+T4 groups. SCH was induced in rats by administration of methimazole (MMI), and rats in the SCH+T4 group were treated with L-T4 after 45 days of MMI administration. The SCH group had higher thyroid-stimulating hormone (TSH) level than the control and SCH+T4 groups...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29144795/relationship-between-the-effectiveness-of-inorganic-iodine-and-the-severity-of-graves-thyrotoxicosis-a-retrospective-study
#18
Akira Honda, Toyoyoshi Uchida, Koji Komiya, Hiromasa Goto, Kageumi Takeno, Junko Sato, Ruriko Suzuki, Miwa Himuro, Hirotaka Watada
OBJECTIVE: Inorganic iodine is often used to treat patients with Graves thyrotoxicosis who do not tolerate thionamides due to adverse effects. However, predictors of continued inorganic iodine efficacy have not been fully elucidated. This study aimed to investigate the factors affecting the continued efficacy of potassium iodide (KI) in patients with Graves thyrotoxicosis. METHODS: In this study, among 1,197 patients with Graves disease who were initially treated with thionamides, we retrospectively studied 24 consecutive Japanese patients whose treatment was changed to KI alone due to the adverse effects of thionamides...
December 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29112772/regulation-of-thyroid-sodium-iodide-symporter-in-different-stages-of-goiter-possible-involvement-of-ros
#19
L P L Matos, R Cortez-Cardoso, L C Cardoso-Weide, M L Freitas, D L S G Silva, A C F Ferreira
Na(+) /I(-) symporter (NIS) transports iodide into thyrocytes, a fundamental step for thyroid hormone biosynthesis. Our aim was to evaluate NIS regulation in different status of goitrogenesis and its underlying mechanisms. Wistar rats were treated with methimazole (MMI) for 5 and 21 days, to achieve different status of goiter. We then evaluated the effect of MMI removal for 1 day (R1d), after 5 (R1d-5d) or 21 (R1d-21d) days of MMI treatment. MMI increased thyroid weight, iodide uptake and in vitro TPO activity in a time-dependent way...
November 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29110662/reliability-of-multiple-mini-interviews-and-traditional-interviews-within-and-between-institutions-a-study-of-five-california-medical-schools
#20
Anthony Jerant, Mark C Henderson, Erin Griffin, Julie A Rainwater, Theodore R Hall, Carolyn J Kelly, Ellena M Peterson, David Wofsy, Peter Franks
BACKGROUND: Many medical schools use admissions Multiple Mini-Interviews (MMIs) rather than traditional interviews (TIs), partly because MMIs are thought to be more reliable. Yet prior studies examined single-school samples of candidates completing either an MMI or TI (not both). Using data from five California public medical schools, the authors examined the within- and between-school reliabilities of TIs and MMIs. METHODS: The analyses included applicants interviewing at ≥1 of the five schools during 2011-2013...
November 6, 2017: BMC Medical Education
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