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https://www.readbyqxmd.com/read/28421674/retraction-statement-dynamic-complex-formation-between-hd-gyp-ggdef-and-pilz-domain-proteins-regulates-motility-in-xanthomonas-campestris
#1
(no author information available yet)
The following article from Molecular Microbiology (2012) 86(3), 557-567, 'Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility in Xanthomonas campestris' by Robert P. Ryan, Yvonne McCarthy, Patrick A. Kiely, Rosemary O'Connor, Chuck S. Farah, Judith P. Armitage and J. Maxwell Dow published online in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, John D Helmann, and John Wiley & Sons Ltd. Since publication of the above article, it has been brought to our attention that there are several image duplications across Figures 3, 5 and 6 including duplication with another article in PNAS: 'Cell-cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris', by Robert P...
May 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28415896/multiple-mini-interviews-mmi-a-perspective-on-the-first-year-of-mmi-at-brighton-and-sussex-medical-school
#2
Simonne Tryb
Since it was developed at McMaster University School of Medicine in 2002, multiple medical interviews (MMI) have become a popular and accepted method of assessing candidates applying for medical training. Unlike a traditional panel interview it resembles the objective structured clinical examination (OSCE) with numerous 8-10 min stations assessing different topics or scenarios pertinent to medical training and healthcare. This was the first year of implementing MMI at Brighton and Sussex Medical School and my first year of interviewing...
April 18, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28387513/heteroleptic-cycloplatinated-n-heterocyclic-carbene-complexes-a-new-approach-to-highly-efficient-blue-light-emitters
#3
Sara Fuertes, Andrés J Chueca, Lorenzo Arnal, Antonio Martín, Umberto Giovanella, Chiara Botta, Violeta Sicilia
New heteroleptic compounds of platinum(II)-containing cyclometalated N-heterocyclic carbenes, [PtCl(R-C^C*)(PPh3)] [R-CH^C*-κC* = 3-methyl-1-(naphthalen-2-yl)-1H-imidazol-2-ylidene (R-C = Naph; 1A), 1-[4-(ethoxycarbonyl)phenyl]-3-methyl-1H-imidazol-2-ylidene (R = CO2Et; 1B), and [Pt(R-C^C*)(py)(PPh3)]PF6 (py = pyridine; R-C = Naph, 2A; R = CO2Et, 2B], have been prepared and fully characterized. All of them were obtained as the trans-(C*,PPh3) isomer in high yields. The selectivity of their synthesis has been explained in terms of the degree of transphobia (T) of pairs of ligands in trans positions...
April 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28386276/cholesterol-synthesis-increased-in-the-mmi-induced-subclinical-hypothyroidism-mice-model
#4
Yongfeng Song, Xiujuan Zhang, Wenbin Chen, Ling Gao
Subclinical hypothyroidism (SCH) is defined as increased serum thyroid-stimulating hormone (TSH) concentrations and normal serum thyroid hormone (TH) levels as well as an increased serum cholesterol level, which is an important cause of secondary hypercholesterolemia and cardiovascular diseases. Some studies have demonstrated a direct effect of TSH on cholesterol metabolism via in vivo and in vitro experiments. However, because no suitable SCH model has been established until now, the changes in cholesterol synthesis that occur in SCH patients remain unknown...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28384391/trends-in-anecdotal-fox-sightings-in-tasmania-accounted-for-by-psychological-factors
#5
Clive A Marks, Malcolm Clark, David Obendorf, Graham P Hall, Inês Soares, Filipe Pereira
There has been little evaluation of anecdotal sightings as a means to confirm new incursions of invasive species. This paper explores the potential for equivocal information communicated by the media to account for patterns of anecdotal reports. In 2001 it was widely reported that red foxes (Vulpes vulpes) had been deliberately released in the island state of Tasmania (Australia), although this claim was later revealed to be baseless. Regardless, by 2013 a total of 3153 anecdotal fox sightings had been reported by members of the public and this implied the wide distribution of foxes...
April 6, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28380944/realization-of-an-ultra-compact-polarization-beam-splitter-using-asymmetric-mmi-based-on-silicon-nitride-silicon-on-insulator-platform
#6
Xiao Sun, J Stewart Aitchison, Mo Mojahedi
We have experimentally demonstrated a compact polarization beam splitter (PBS) based on the silicon nitride/silicon-on-insulator platform using the recently proposed augmented-low-index-guiding (ALIG) waveguide structure. The two orthogonal polarizations are split in an asymmetric multimode interference (MMI) section, which was 1.6 μm wide and 4.8 μm long. The device works well over the entire C-band wavelength range and has a measured low insertion loss of less than 1 dB. The polarization extinction ratio at the Bar Port is approximately 17 dB and at the Cross Port is approximately 25 dB...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28380797/coreless-side-polished-fiber-a-novel-fiber-structure-for-multimode-interference-and-highly-sensitive-refractive-index-sensors
#7
Huazhuo Dong, Liheng Chen, Junjie Zhou, Jianhui Yu, Heyuan Guan, Wentao Qiu, Jiangli Dong, Huihui Lu, Jieyuan Tang, Wenguo Zhu, Zhigang Cai, Yi Xiao, Jun Zhang, Zhe Chen
A novel fiber structure, coreless side-polished fiber (CSPF), is proposed and investigated to implement multimode interference (MMI) and high sensitive refractive index (RI) sensors. For such CSPF, the part of the cladding and the core of a single-mode fiber are side-polished off so as to make the remained cladding a D-shaped multimode waveguide. The excitation and evolution of MMI in the CSPF are simulated numerically. The simulation results show that the high-order modes excited within the D-shaped multimode waveguide are mainly TE<sub>0,1</sub> (TM<sub>0,1</sub>)~TE<sub>0,6</sub> (TM<sub>0,6</sub>) modes...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28380749/passive-athermalization-of-multimode-interference-devices-for-wavelength-locking-applications
#8
Victor I Ruiz-Perez, Daniel A May-Arrioja, Jose R Guzman-Sepulveda
In this paper we demonstrate the passive, material-based athermalization of all-fiber architectures by cascading multimode interference (MMI) devices. In-line thermal compensation is achieved by including a liquid-core multimode section of variable length that allows ensuring temperature-independent operation while preserving the inherent filter-like spectral response of the MMI devices. The design of the temperature compensation unit is straightforward and its fabrication is simple. The applicability of our approach is experimentally verified by fabricating a wavelength-locked MMI laser with sensitivity of only -0...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28371777/facial-expression-recognition-based-on-deep-evolutional-spatial-temporal-networks
#9
Kaihao Zhang, Yongzhen Huang, Yong Du, Liang Wang
One key challenging issue of facial expression recognition is to capture the dynamic variation of facial physical structure from videos. In this paper, we propose a Part-based Hierarchical Bidirectional Recurrent Neural Network (PHRNN) to analyze the facial expression information of temporal sequences. Our PHRNN models facial morphological variations and dynamical evolution of expressions, which is effective to extract "temporal features" based on facial landmarks (geometry information) from consecutive frames...
March 30, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28368976/optical-coherence-tomography-angiography-to-distinguish-choroidal-neovascularization-from-macular-inflammatory-lesions-in-multifocal-choroiditis
#10
Polina Astroz, Alexandra Miere, Sarah Mrejen, Rim Sekfali, Eric H Souied, Camille Jung, Sylvia Nghiem-Buffet, Salomon Y Cohen
PURPOSE: To characterize the macular lesions in multifocal choroiditis using multimodal imaging (MMI) and to evaluate optical coherence tomography angiography (OCTA) in distinguishing neovascular from inflammatory lesions. METHODS: Retrospective review of medical records of consecutive patients diagnosed with multifocal choroiditis and macular involvement, between September 2014 and May 2016, were included. All patients underwent standard examination and MMI, including fundus color photography, fundus autofluorescence, fluorescein angiography, and spectral domain optical coherence tomography...
March 30, 2017: Retina
https://www.readbyqxmd.com/read/28344326/mutual-information-model-for-link-prediction-in-heterogeneous-complex-networks
#11
Hadi Shakibian, Nasrollah Moghadam Charkari
Recently, a number of meta-path based similarity indices like PathSim, HeteSim, and random walk have been proposed for link prediction in heterogeneous complex networks. However, these indices suffer from two major drawbacks. Firstly, they are primarily dependent on the connectivity degrees of node pairs without considering the further information provided by the given meta-path. Secondly, most of them are required to use a single and usually symmetric meta-path in advance. Hence, employing a set of different meta-paths is not straightforward...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341216/effects-of-methimazole-on-drosophila-glucolipid-metabolism-in-vitro-and-in-vivo
#12
Qi Wei, Bo Hu, Yuan Xue, David Kibe Mburu, Xian Tao, Jianya Su
Methimazole (MMI) is an antithyroid agent widely used in the treatment of hyperthyroidism, and metabolized by cytochrome P450 enzymes and flavin-containing monooxygenases in mammals. However, drug overdose and the inadequate detoxification of the metabolite(s) are responsible for hepatocellular damage and organ dysfunction. Depending on the desired properties, Drosophila melanogaster has recently emerged as an ideal model organism for the study of human diseases. Here we investigated the changes in metabolic profiles and mRNA expressions related to glucolipid metabolism in response to treatment with MMI in Drosophila...
March 21, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28324105/thyroid-hormone-dependent-epigenetic-regulation-of-melanocortin-4-receptor-levels-in-female-offspring-of-obese-rats
#13
Tzlil Tabachnik, Tatiana Kisliouk, Asaf Marco, Noam Meiri, Aron Weller
Maternal obesity is a risk factor for offspring obesity. The melanocortin 4 receptor (Mc4r) is one of the mediators of food intake and energy balance. The present study examined the epigenetic mechanisms underlying altered Mc4r levels in the hypothalamic paraventricular nucleus in the offspring of high-fat diet (HFD)-induced obese dams and sought to elucidate the role of thyroid hormones in epigenetic regulation and tagging of their nucleosome at the Mc4r promoter. Female Wistar rats were fed an HFD or standard chow from weaning through gestation and lactation...
April 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28302124/reliability-and-acceptability-of-six-station-multiple-mini-interviews-past-behavioural-versus-situational-questions-in-postgraduate-medical-admission
#14
Toru Yamada, Juichi Sato, Hiroshi Yoshimura, Tomoya Okubo, Eiji Hiraoka, Takashi Shiga, Tadao Kubota, Shigeki Fujitani, Junji Machi, Nobutaro Ban
BACKGROUND: The multiple mini-interview (MMI) is increasingly used for postgraduate medical admissions and in undergraduate settings. MMIs use mostly Situational Questions (SQs) rather than Past-Behavioural Questions (PBQs). A previous study of MMIs in this setting, where PBQs and SQs were asked in the same order, reported that the reliability of PBQs was non-inferior to SQs and that SQs were more acceptable to candidates. The order in which the questions are asked may affect reliability and acceptability of an MMI...
March 16, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28279752/novel-spiroimidazopyridine-derivative-sak3-improves-methimazole-induced-cognitive-deficits-in-mice
#15
Husain Noreen, Yasushi Yabuki, Kohji Fukunaga
Methimazole (MMI) is a first-line therapy used to manage hyperthyroidism and Graves' disease. Despite its therapeutic benefit, chronic MMI administration can lead to hypothyroidism and perturb brain homeostasis in patients, resulting in neuropsychiatric disorders such as depression and cognitive dysfunction. We recently developed the spiroimidazopyridine derivative SAK3 as cognitive enhancer; however, mechanisms underlying its activity remained unclear. Here, we show that SAK3 potentially improves cognitive impairment seen following MMI-induced hypothyroidism...
March 6, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28272341/liver-effects-of-clinical-drugs-differentiated-in-human-liver-slices
#16
Alison E M Vickers, Anatoly V Ulyanov, Robyn L Fisher
Drugs with clinical adverse effects are compared in an ex vivo 3-dimensional multi-cellular human liver slice model. Functional markers of oxidative stress and mitochondrial function, glutathione GSH and ATP levels, were affected by acetaminophen (APAP, 1 mM), diclofenac (DCF, 1 mM) and etomoxir (ETM, 100 μM). Drugs targeting mitochondria more than GSH were dantrolene (DTL, 10 μM) and cyclosporin A (CSA, 10 μM), while GSH was affected more than ATP by methimazole (MMI, 500 μM), terbinafine (TBF, 100 μM), and carbamazepine (CBZ 100 μM)...
March 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28264549/the-utility-of-multiple-mini-interviews-experience-of-a-medical-school
#17
Kyong-Jee Kim, Kyung-Soo Nam, Bum Sun Kwon
PURPOSE: This paper aims to introduce the design of multiple mini-interviews (MMIs) as a tool to assess medical school applicants' attributes in alignment with the school's educational goals and to evaluate its utility. METHODS: In this MMI, candidates rotated through six stations (10 minutes per station), in which specific interview topics were drawn by mapping the school's educational goals with the core competencies for entering medical students. We conducted post-MMI surveys of all of the interviewers and candidates to investigate their experiences of MMIs...
March 2017: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/28216885/simultaneous-determination-of-eight-phenolic-acids-five-saponins-and-four-tanshinones-for-quality-control-of-compound-preparations-containing-danshen-sanqi-herb-pair-by-hplc-dad
#18
Hong Yao, Xiaomei Huang, Shaoguang Li, Youjia Wu, Xinhua Lin, Peiying Shi
BACKGROUND: The herb-pair, Salviaemiltiorrhizae (Danshen, DS) and Panaxnotoginseng (Sanqi,SQ), often occurs in traditional Chinese medicine prescriptions used for the treatment of cardiovascular diseases in clinics in Asian areas. Many commercial preparations containing the DS-SQ herb-pair were produced by various manufactures with the different production process. The raw materials were from different sources, which raised a challenge to control the quality of the herb-pair medicines...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28203042/relationship-between-dose-of-antithyroid-drugs-and-adverse-events-in-pediatric-patients-with-graves-disease
#19
Kie Yasuda, Yoko Miyoshi, Makiko Tachibana, Noriyuki Namba, Kazunori Miki, Yukiko Nakata, Toru Takano, Keiichi Ozono
Graves' disease (GD) accounts for a large proportion of pediatric hyperthyroidism, and the first-line treatment is antithyroid drug (ATD) therapy. Methimazole (MMI) is effective in most patients but is associated with significant adverse events (AEs). We reviewed the medical records of GD patients (n = 56) with onset age of <15 yr and investigated the relationship between MMI dose and AEs. The study population comprised 11 male and 45 female patients and the median age at diagnosis was 11 yr. All patients were initially treated with ATDs...
January 2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28192819/mir-346-and-trab-as-predicative-factors-for-relapse-in-graves-disease-within-one-year
#20
Jianhui Li, Yawei Cai, Xiaohua Sun, Danzhen Yao, Jinying Xia
Despite the efficacy and safety, antithyroid drug (ATD) therapy for Graves' disease (GD) is associated with a high risk of relapse, especially within the first year. The inability to predict whether and when relapse may occur is a major problem for ATD therapy. This study was aimed to investigate potential predicative factors for GD patients after ATD withdrawal. Consecutive patients newly diagnosed with GD and treated with ATD [methimazole (MMI)] were enrolled in this study. Univariate and multivariate Cox proportional hazard analyses were used for the analysis of predicative parameters for GD relapse after MMI withdrawal...
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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