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https://www.readbyqxmd.com/read/27905663/identifying-applicants-suitable-to-a-career-in-nursing-a-value-based-approach-to-undergraduate-selection
#1
Marian Traynor, Despina Galanouli, Martin Roberts, Lawrence Leonard, Thomas Gale
AIMS: To complement existing evidence on the suitability of Multiple Mini Interviews as potential tool for the selection of nursing candidates on to a BSc (Hons) nursing programme. BACKGROUND: This study aimed to trial the Multiple Mini Interview approach to recruitment with a group of first year nursing students (already selected using traditional interviews). DESIGN: Cross-sectional validation study. This paper reports on the evaluation of the participants' detailed scores from the Multiple Mini Interview stations; their original interview scores and their end of year results...
December 1, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27904672/t3-inhibits-the-calcification-of-vascular-smooth-muscle-cells-and-the-potential-mechanism
#2
Xiaodan Chang, Baohong Zhang, Li Lihua, Zhichun Feng
OBJECTIVE: This study aimed to investigate the potential molecular mechanism underlying the T3 induced vascular calcification and phenotype transformation of vascular smooth muscle cells (VSMCs). METHODS: Rat thoracic aortic smooth muscle cells (A7r5) were cultured in vitro and randomly assigned into normal control group, calcification group, T3 group and inhibitor group. RESULTS: When compared with normal control group, the osteocalcin content, ALP activity, Osterix and Runx2 mRNA expression and OPN protein expression increased significantly (P<0...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27875237/automatic-facial-expression-recognition-system-using-deep-network-based-data-fusion
#3
Anima Majumder, Laxmidhar Behera, Venkatesh K Subramanian
This paper presents a novel automatic facial expressions recognition system (AFERS) using the deep network framework. The proposed AFERS consists of four steps: 1) geometric features extraction; 2) regional local binary pattern (LBP) features extraction; 3) fusion of both the features using autoencoders; and 4) classification using Kohonen self-organizing map (SOM)-based classifier. This paper makes three distinct contributions. The proposed deep network consisting of autoencoders and the SOM-based classifier is computationally more efficient and performance wise more accurate...
November 17, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27866307/explicating-the-conditions-under-which-multilevel-multiple-imputation-mitigates-bias-resulting-from-random-coefficient-dependent-missing-longitudinal-data
#4
Nisha C Gottfredson, Sonya K Sterba, Kristina M Jackson
Random coefficient-dependent (RCD) missingness is a non-ignorable mechanism through which missing data can arise in longitudinal designs. RCD, for which we cannot test, is a problematic form of missingness that occurs if subject-specific random effects correlate with propensity for missingness or dropout. Particularly when covariate missingness is a problem, investigators typically handle missing longitudinal data by using single-level multiple imputation procedures implemented with long-format data, which ignores within-person dependency entirely, or implemented with wide-format (i...
November 19, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/27853063/successful-re-administration-of-low-dose-of-methimazole-mmi-in-graves-disease-patients-who-experienced-allergic-cutaneous-reactions-to-mmi-at-initial-treatment-and-had-received-long-term-propylthiouracil-ptu
#5
Sumihisa Kubota
Objective When patients with Graves' disease show severe allergic cutaneous reactions, physicians often suggest that they undergo radioiodine therapy instead of receiving propylthiouracil (PTU), another antithyroid drug, because anti-neutrophil cytoplasmic antibody (ANCA) -related vasculitis can occur with PTU, especially with long-term use. However, some patients refuse radioiodine therapy and chose PTU. Sometimes PTU treatment may be prolonged. Since the frequency of adverse effects of methimazole (MMI) is dose-related, there is a possibility that we can re-administer a low dose without adverse effects to patients well-controlled with PTU who once experienced an allergic reaction to MMI...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27832996/quercetin-changes-purinergic-enzyme-activities-and-oxidative-profile-in-platelets-of-rats-with-hypothyroidism
#6
Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Daniela Zanini, Andréia M Cardoso, Fátima H Abadalla, Gustavo R Thomé, Camila Murussi, Carla R N Polachini, Diéssica P Delenogare, Vania L Loro, Vera M Morsch, Maria R C Schetinger
Diseases related to thyroid hormones have been extensively studied because affect a large number of individuals, and these hormones participate in the regulation of the whole organism homeostasis. However, little is known about the involvement of purinergic signaling related to oxidative stress in hypothyroidism and possible therapeutic adjuncts for treatment of this disorder. Thus, the present study investigates the effects of quercetin on NTPDase, 5'-nucleotidase and adenosine deaminase activities, platelet aggregation and oxidative profile in platelets of rats with methimazole (MMI)-induced hypothyroidism...
November 7, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27828321/analysis-of-multimode-interferometers
#7
Kieran Cooney, Frank H Peters
A general analytical formula describing the transfer function between the input and output of an arbitrary rectangular multimode interference (MMI) coupler has been derived using the elliptic theta function ϑ(x', z'). This formula provides the positions, amplitudes and relative phases of all the self-images of a given source. It is shown how the transfer function can be used as a propagation matrix for any rectangular NxM MMI. Specific simplified solutions for NxN, symmetric and paired MMIs are also derived from the general formula...
October 3, 2016: Optics Express
https://www.readbyqxmd.com/read/27803210/can-multiple-mini-interviews-predict-academic-performance-of-dental-students-a-two-year-follow-up
#8
Sumer M Alaki, Ibrahim A Yamany, Lana A Shinawi, Mona H A Hassan, Ara Tekian
Prior research has shown that students' previous grade point average (GPA) is the best predictor for future academic success. However, it can only partly predict the variability in dental school performance. The aim of this study was to assess the predictive value of multiple mini-interviews (MMI) as an admission criterion by comparing them with the academic performance of dental students over a two-year period. All incoming undergraduate dental students at the King Abdulaziz University Faculty of Dentistry (KAUFD) during academic year 2013-14 were invited to participate in MMI...
November 2016: Journal of Dental Education
https://www.readbyqxmd.com/read/27793676/hormonal-and-testicular-changes-in-rats-submitted-to-congenital-hypothyroidism-in-early-life
#9
Veronica Aiceles, Flavia Gombar, Cristiane da Fonte Ramos
The goal of this study was to evaluate the influence of hypothyroidism induced by MMI, during gestation (G) or gestation plus lactation (GL) on testis and its relation with leptin in rats. Six to eight pups were killed at 90 days of age. For statistical analysis One-way ANOVA followed by the Holm-Sìdak post hoc test was used. Hypothyroidism resulted in a significant reduction in LH, FSH and testosterone and an increase in leptin serum levels (p < 0.04). There was a significant decrease in StAR, AR, FSHR, LHR, pSTAT3 and SOCS3 (p < 0...
October 25, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27760091/-body-composition-analysis-performed-by-bioimpedance-in-patients-with-chronic-obstructive-pulmonary-disease
#10
Renata Rubinsztajn, Tadeusz Przybyłowski, Marta Maskey-Warzęchowska, Krzysztof Karwat, Ryszarda Chazan
: Body composition disorders are observed in chronic obstructive pulmonary disease (COPD) patients and have a significant impact the general condition and outcome in this disease. AIM: The aim of the study was to assess body composition in relation to airway obstruction severity in patients with COPD. MATERIALS AND METHODS: The study group consisted of 143 patients (58F, 85M) in the middle age The group was divided to two groups: group A FEV1<50% predicted and group B FEV1 ≥50% predicted; both groups were compared...
October 19, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27756929/the-multiple-mini-interview-as-an-admission-tool-for-a-pharmd-program-satellite-campus
#11
David Singer, Jacqueline E McLaughlin, Wendy C Cox
Objective. To assess the multiple mini-interview (MMI) as an admission tool for a satellite campus. Methods. In 2013, the MMI was implemented as part of a new admissions model at the UNC Eshelman School of Pharmacy. From fall 2013 to spring 2015, 73 candidates were interviewed by 15 raters on the satellite campus in Asheville, North Carolina. A many-facet Rasch measurement (MFRM) with three facets was used to determine the variance in candidate ratings attributable to rater severity, candidate ability, and station difficulty...
September 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27734319/effects-of-selenium-on-short-term-control-of-hyperthyroidism-due-to-graves-disease-treated-with-methimazole-results-of-a-randomized-clinical-trial
#12
M Leo, L Bartalena, G Rotondo Dottore, E Piantanida, P Premoli, I Ionni, M Di Cera, E Masiello, L Sassi, M L Tanda, F Latrofa, P Vitti, C Marcocci, M Marinò
OBJECTIVE: In spite of previous conflicting results, an adjuvant role of selenium in the treatment of Graves' disease (GD) hyperthyroidism has been proposed. To address this issue, a randomized clinical trial was carried out aimed at investigating whether selenium is beneficial on the short-term control of GD hyperthyroidism treated with methimazole (MMI). METHODS: Thirty newly diagnosed hyperthyroid GD patients were randomly assigned to treatment with: (i) MMI or (ii) MMI plus selenium...
October 12, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27733025/reduction-of-midline-shift-following-decompressive-hemicraniectomy-for-malignant-middle-cerebral-artery-infarction
#13
Sang-Beom Jeon, Sun U Kwon, Jung Cheol Park, Deok Hee Lee, Sung-Cheol Yun, Yeon-Jung Kim, Jae-Sung Ahn, Byung-Duk Kwun, Dong-Wha Kang, H Alex Choi, Kiwon Lee, Jong S Kim
BACKGROUND AND PURPOSE: Hemicraniectomy is a decompressive surgery used to remove a large bone flap to allow edematous brain tissue to bulge extracranially. However, early indicators of the decompressive effects of hemicraniectomy are unclear. We investigated whether reduction of midline shift following hemicraniectomy is associated with improved consciousness and survival in patients with malignant middle cerebral artery infarctions. METHODS: We studied 70 patients with malignant middle cerebral artery infarctions (MMI) who underwent hemicraniectomies...
September 2016: Journal of Stroke
https://www.readbyqxmd.com/read/27732097/variables-affecting-the-long-term-outcome-of-graves-orbitopathy-following-high-dose-intravenous-glucocorticoid-pulse-therapy-in-patients-not-treated-with-orbital-radiotherapy
#14
Marenza Leo, Teresa Mautone, Ilaria Ionni, Maria Antonietta Profilo, Elena Sabini, Francesca Menconi, Barbara Mazzi, Roberto Rocchi, Francesco Latrofa, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò
OBJECTIVE: Intravenous (iv) glucocorticoids (GC) (ivGC) are used for active Graves orbitopathy (GO), but factors affecting GO outcome are poorly understood. We performed a retrospective study to investigate the variables affecting GO after ivGC. METHODS: We evaluated 83 consecutive GO patients treated with ivGC but not orbital radiotherapy (ORT) and re-examined them after a median of 47 months. The endpoints were the relationships between GO outcome or additional treatments with age, sex, smoking habits, thyroid volume, thyroid treatment, time since thyroid treatment, antithyroid-stimulating hormone receptor antibodies (TRAb), GO duration, GO features, and follow-up time...
October 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27723592/learning-expressionlets-via-universal-manifold-model-for-dynamic-facial-expression-recognition
#15
Mengyi Liu, Shiguang Shan, Ruiping Wang, Xilin Chen
Facial expression is a temporally dynamic event which can be decomposed into a set of muscle motions occurring in different facial regions over various time intervals. For dynamic expression recognition, two key issues, temporal alignment and semantics-aware dynamic representation, must be taken into account. In this paper, we attempt to solve both problems via manifold modeling of videos based on a novel midlevel representation, i.e. expressionlet. Specifically, our method contains three key stages: 1) each expression video clip is characterized as a spatial-temporal manifold (STM) formed by dense low-level features; 2) a Universal Manifold Model (UMM) is learned over all low-level features and represented as a set of local modes to statistically unify all the STMs...
October 5, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27716671/effects-of-tooth-loss-and-the-apolipoprotein-e-%C3%A9-4-allele-on-mild-memory-impairment-in-the-fujiwara-kyo-study-of-japan-a-nested-case-control-study
#16
Nozomi Okamoto, Masayuki Morikawa, Nobuko Amano, Motokazu Yanagi, Shin Takasawa, Norio Kurumatani
BACKGROUND: Several studies have suggested that periodontal disease can exacerbate the pro-inflammatory status of the brain. Tooth loss is one of the alternative evaluation indices of periodontal disease. There are few data on the relationship between tooth loss and memory impairment, depending on the apolipoprotein E (APOE) ɛ4 genotype. OBJECTIVE: To determine if tooth loss is associated with mild memory impairment (MMI) and if this association is modified by the presence of the APOEɛ4 allele...
October 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27677692/predicting-protein-protein-interactions-via-multivariate-mutual-information-of-protein-sequences
#17
Yijie Ding, Jijun Tang, Fei Guo
BACKGROUND: Protein-protein interactions (PPIs) are central to a lot of biological processes. Many algorithms and methods have been developed to predict PPIs and protein interaction networks. However, the application of most existing methods is limited since they are difficult to compute and rely on a large number of homologous proteins and interaction marks of protein partners. In this paper, we propose a novel sequence-based approach with multivariate mutual information (MMI) of protein feature representation, for predicting PPIs via Random Forest (RF)...
September 27, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27667835/an-examination-of-correlations-between-mmi-scores-and-pharmacy-school-gpa
#18
Kevin Cowart, Kamila Dell, Nazach Rodriguez-Snapp, Heather M W Petrelli
Objective. To investigate the correlation of mean admission multiple mini-interview (MMI) scores with cumulative and overall GPA across didactic years 1-3 in the doctor of pharmacy (PharmD) curriculum. Methods. The mean admission MMI score and cumulative and overall GPA for first year (P1), second year (P2), and third year (P3) students in the PharmD curriculum was used to conduct a multiple regression analysis and to calculate a Pearson correlation coefficient. Statistical analysis was performed using SPSS, v20...
August 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27666950/mentor-mentee-interaction-and-laboratory-social-environment-do-they-matter-in-doctoral-students-publication-productivity
#19
Marcus Antonius Ynalvez, Ruby A Ynalvez, Enrique Ramírez
We explored the social shaping of science at the micro-level reality of face-to-face interaction in one of the traditional places for scientific activities-the scientific lab. We specifically examined how doctoral students' perception of their: (i) interaction with doctoral mentors (MMI) and (ii) lab social environment (LSE) influenced productivity. Construed as the production of peer-reviewed articles, we measured productivity using total number of articles (TOTAL), number of articles with impact factor greater than or equal to 4...
September 26, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27637732/mir-122-involved-in-the-regulation-of-toll-like-receptor-signaling-pathway-after-vibrio-anguillarum-infection-by-targeting-tlr14-in-miiuy-croaker
#20
Junxia Cui, Qing Chu, Tianjun Xu
Innate and acquired immune responses provide critical line in defense against pathogens. MicroRNAs (miRNAs) play crucial roles in regulate gene expression in inflammation and innate immunity. However, the main role of miRNAs are in a large part unclear in aquatic organisms. In this study, we found that miR-122 displayed dramatically declined expression profiles in Vibrio anguillarum challenged miiuy croaker. Meanwhile, we have explored TLR14 as a novel target gene of miR-122 involved in miiuy croakers inflammatory and immune response, which were further estimated through negative expression profiles in both Vibrio anguillarum challenged miiuy croaker and LPS exposure macrophages...
September 13, 2016: Fish & Shellfish Immunology
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