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Dan Wang, Zhang Zhang, Fan Yang, Le Zhang, Zhenwen Yang, Wen Ren, Tielian Yu, Dong Li
BACKGROUND: To study the characteristics of ventricular function in Pulmonary Hypertension (PH) Patients with different shape of Interventricular Septum (IVS) by cardiac magnetic resonance (CMR). METHODS: 36 PH patients diagnosed by right heart catheterization accepted CMR. According to the morphology of IVS, the patients were divided into two groups: the non-deformation group (10 patients) and the deformation group (26 patients). The ventricular function parameters were as follows: RV and LV end-diastolic volume index (EDVI), end-systolic volume index (ESVI), stroke volume index (SVI), cardiac index (CI), ejection fraction (EF), and myocardial mass index (MMI)...
May 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Naoki Arai, Kenji Nemoto, Shuji Oh-Ishi, Mizu Nonaka, Kenji Hayashihara, Takefumi Saito
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) caused by methimazole (MMI) is known to be relatively rare; therefore, the optimal therapeutic approach for these cases remains to be established. A 59-year-old man who was treated with MMI for a diagnosis of Graves' disease was referred to our hospital because of progressive haemoptysis. The patient was diagnosed with diffuse alveolar haemorrhage (DAH) secondary to AAV based on increased inflammatory reactions with positive myeloperoxidase-ANCA in the serum and the results of bronchoalveolar lavage fluid...
July 2018: Respirology Case Reports
Federico S Lucia, Jesús Pacheco-Torres, Susana González-Granero, Santiago Canals, María-Jesús Obregón, José M García-Verdugo, Pere Berbel
Thyroid hormone deficiency at early postnatal ages affects the cytoarchitecture and function of neocortical and telencephalic limbic areas, leading to impaired associative memory and in a wide spectrum of neurological and mental diseases. Neocortical areas project interhemispheric axons mostly through the corpus callosum and to a lesser extent through the anterior commissure (AC), while limbic areas mostly project through the AC and hippocampal commissures. Functional magnetic resonance data from children with late diagnosed congenital hypothyroidism and abnormal verbal memory processing, suggest altered ipsilateral and contralateral telencephalic connections...
2018: Frontiers in Neuroanatomy
Mirjana Knorr, Anja Schwibbe, Maren Ehrhardt, Janina Lackamp, Stefan Zimmermann, Wolfgang Hampe
BACKGROUND: Multiple mini-interviews (MMI) become increasingly popular for the selection of medical students. In this work, we examine the validity evidence for the Hamburg MMI. METHODS: We conducted three follow-up studies for the 2014 cohort of applicants to medical school over the course of two years. We calculated Spearman's rank correlation (ρ) between MMI results and (1) emotional intelligence measured by the Trait Emotional Intelligence Questionnaire (TEIQue-SF) and the Situational Test of Emotion Management (STEM), (2) supervisors' and practice team members' evaluations of psychosocial competencies and suitability for the medical profession after a one-week 1:1 teaching in a general practice (GP) and (3) objective structured clinical examination (OSCE) scores...
May 14, 2018: BMC Medical Education
Kai Chen, Hai Yan Yu, Ji Wei Zhang, Bei Xin Wang, Qiu Wen Chen
Improving the stability of integrity of biotic index (IBI; i.e., multi-metric indices, MMI) across temporal and spatial scales is one of the most important issues in water ecosystem integrity bioassessment and water environment management. Using datasets of field-based macroinvertebrate and physicochemical variables and GIS-based natural predictors (e.g., geomorphology and climate) and land use variables collected at 227 river sites from 2004 to 2011 across the Zhejiang Province, China, we used random forests (RF) to adjust the effects of natural variations at temporal and spatial scales on macroinvertebrate metrics...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Michael D Wolcott, Jacqueline M Zeeman, Wendy C Cox, Jacqueline E McLaughlin
BACKGROUND: The multiple mini-interview (MMI) is a common assessment strategy used in student selection. The MMI as an assessment strategy within a health professions curriculum, however, has not been previously studied. This study describes the integration of a 5-station MMI as part of an end-of-year capstone following the first year of a health professions curriculum. The goal of the capstone MMI was to assess professional competencies of students and to offer formative feedback to prepare students for their upcoming clinical practice experiences...
May 3, 2018: BMC Medical Education
Reza Heidari, Fatemeh Ahmadi, Hamid Reza Rahimi, Negar Azarpira, Massood Hosseinzadeh, Asma Najibi, Hossein Niknahad
Drug-induced liver injury is a major concern in clinical studies as well as in post-marketing surveillance. Previous evidence suggested that drug exposure during periods of inflammation could increase an individual's susceptibility to drug hepatoxicity. The antithyroid drugs, methimazole (MMI) and propylthiouracil (PTU) can cause adverse reactions in patients, with liver as a usual target. We tested the hypothesis that MMI and PTU could be rendered hepatotoxic in animals undergoing a modest inflammation. Mice were treated with a nonhepatotoxic dose of LPS (100 µg/kg, i...
May 3, 2018: Drug and Chemical Toxicology
Caiyan He, Junbin Fang, Yanan Zhang, Yu Yang, Jianhui Yu, Jun Zhang, Heyuan Guan, Wentao Qiu, Pengjun Wu, Jiangli Dong, Huihui Lu, Jieyuan Tang, Wenguo Zhu, N Arsad, Yi Xiao, Zhe Chen
A novel fiber structure, coreless side-polished fiber (CSPF) that is wrapped by polydimethylsiloxane (PDMS), is demonstrated to be highly sensitive to temperature because of the high refractive index sensitivity of the CSPF and the large thermal optic coefficient of the PDMS. Our numerical and experimental results show that the several dips in the transmitted spectra of PDMSW-CSPF is originated from the multimode interference (MMI) in the CSPF and will blueshift with the increase of temperature. Furthermore, for such a PDMSW-CSPF, we investigate its temperature sensing characteristics and the influences of residual thickness (RT) and dip wavelength on the sensitivity both numerically and experimentally...
April 16, 2018: Optics Express
Franco Lumachi, Stefano M M Basso, Valentina Camozzi, Roberto Spaziante, Paolo Ubiali, Mario Ermani
BACKGROUND/AIM: We performed a case-control study to evaluate whether bone mineral density (BMD) can be considered a potential predictive factor for luminal-type breast cancer (BC), that could be useful in constructing a predictive risk model. MATERIALS AND METHODS: The medical records of 297 postmenopausal women with luminal-type node-negative BC who underwent lumbar-spine dual-energy X-ray absorptiometry (DXA) with BMD measurement before surgery, were analyzed and compared with those of 297 age-matched randomly selected healthy controls...
May 2018: Anticancer Research
Narendra Kumar, Shailaja Bhardwaj, Eqram Rahman
Introduction: Patient satisfaction and health care outcomes are directly linked to useful communication skills. Therefore, excellent interpersonal skills are imperative for health care professionals. Multiple mini-interview (MMI) is designed as a selection tool to assess the communication skills of applicants in medical schools during the admission process. However, objective structured clinical examination (OSCE) assesses students' communication and clinical skills at the end of their academic terms...
2018: Advances in Medical Education and Practice
Xuedi Chen, Cuixia Gao, Ningning Gong, Yu Wang, Limin Tian
Objective: The main purpose of this study was to explore the relationships between serca2a, Ryr2, adipokines, and the left ventricular function in the subclinical hypothyroidism with different TSH levels and to determine the impact of L-T4 treatment on these indexes. Methods: Sixty-five male Wistar rats were randomly divided into five groups: control group; sHT A, B, and C group; and sHT + T4 group. The sHT rats were induced by methimazole (MMI), and the sHT + T4 rats were administered with L-T4 treatment after 8 weeks of MMI administration...
2018: International Journal of Endocrinology
Wu Cheng, Keigo Hirakawa
Most conventional imaging modalities detect light indirectly by observing high-energy photons. The random nature of photon emission and detection is often the dominant sources of noise in imaging. Such case is referred to as photon-limited imaging, and the noise distribution is well modeled as Poisson. Multiplicative multiscale innovation (MMI) presents a natural model for Poisson count measurement, where the inter-scale relation is represented as random partitioning (binomial distribution) or local image contrast...
July 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Mengxuan Lyu, Jiaxing Chen, Yiqi Jiang, Wei Dong, Zhou Fang, Shuaicheng Li
BACKGROUND: Microbial abundance profiles are applied widely to understand diseases from the aspect of microbial communities. By investigating the abundance associations of species or genes, we can construct molecular ecological networks (MENs). The MENs are often constructed by calculating the Pearson correlation coefficient (PCC) between genes. In this work, we also applied multimodal mutual information (MMI) to construct MENs. The members which drive the concerned MENs are referred to as key drivers...
April 11, 2018: BMC Systems Biology
Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Caroline C Martins, Daniela Zanini, Karine P Reichert, Gustavo R Thomé, Taís V Palma, Pauline da Costa, Vera M Morsch, Maria R C Schetinger
The purinergic system has an important role in the regulation of vascular functions. The interference of thyroid hormones in this system and in cardiovascular events has been studied in recent years. However, the mechanisms involved in vascular, purinergic, and oxidative changes in thyroid disorders are not completely understood. Therefore, the present study aimed to assess purinergic enzyme activity in platelets from rats with hypothyroidism and hyperthyroidism induced, respectively, by continuous exposure to methimazole (MMI) at 20 mg/100 mL or L-thyroxine at 1...
April 16, 2018: Journal of Cellular Biochemistry
Matthew A Stott, Vahid Ganjalizadeh, Maclain Olsen, Marcos Orfila, Johnny McMurray, Holger Schmidt, Aaron R Hawkins
Multimode interference (MMI) waveguides can be used for multiplexing and de-multiplexing optical signals. High fidelity, wavelength dependent multi-spot patterns from MMI waveguides are useful for sensitive and simultaneous identification of multiple targets in multiplexed fluorescence optofluidic biosensors. Through experiments and simulation, this paper explores design parameters for an MMI rib anti-resonant reflecting optical waveguide (ARROW) in order to produce high fidelity spot patterns at the liquid core biomarker excitation region...
June 2018: IEEE Journal of Quantum Electronics
Ayesha Rauf, Ali Tayyab, Amena Masrur
OBJECTIVE: To investigate the relationship between the performances of students in non-cognitive skills in Multiple Mini Interview (MMI) and Integrated Practical Examination (IPE) of the first year of medical school. STUDY DESIGN: Cross-sectional observation study with statistical support. PLACE AND DURATION OF STUDY: Shifa College of Medicine/Shifa Tameer-e-Millat University, Islamabad between December 2015 and March 2016. METHODOLOGY: Student performance in communication skills, domain of the 8-station Multiple Mini Interview, was compared with their scores in communication skills in the first Integrated Practical Examination taken at the end of first block...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Keigo Aramaki, Hiroyuki Uenohara
We have proposed and investigated the tolerable performance of an optical serial-to-parallel converter with phase operation (OSPC) with lower power consumption than the conventional scheme for the purpose of achieving reduction of both the processing load and the processing latency of the high-speed packet switching systems in the data center. The target OSPC consists of Mach-Zehnder delay interferometers (MZDIs) and balanced photodetectors with silicon (Si) photonic technology. However, we have confirmed that the performance becomes degraded due to optical propagation losses of the delay lines in MZDIs...
March 19, 2018: Optics Express
Noreen Husain, Yasushi Yabuki, Yasuharu Shinoda, Kohji Fukunaga
Hypothyroidism is a common disorder that is associated with psychological disturbances such as dementia, depression, and psychomotor disorders. We recently found that chronic treatment with the T-type calcium channel enhancer SAK3 prevents the cholinergic neurodegeneration induced by a single intraperitoneal (i.p.) injection of methimazole (MMI; 75 mg/kg), thereby improving cognition. Here, we evaluated the acute effect of SAK3 on cognitive impairments and its mechanism of action following the induction of hypothyroidism...
March 29, 2018: Pharmacology
Anthony Jerant, Mark C Henderson, Erin Griffin, Theodore R Hall, Carolyn J Kelly, Ellena M Peterson, David Wofsy, Peter Franks
PURPOSE: In single-school studies, multiple mini-interview (MMI) and traditional interview (TI) scores are associated with acceptance offers. Unexamined is whether scores at one school are associated with acceptance at other schools; such analyses would mitigate single-school design biases and better estimate how well interviews capture desired applicant attributes. Using data from the five California Longitudinal Evaluation of Admissions Practices (CA-LEAP) public medical schools, the authors examined associations of MMI and TI scores with acceptance offers within and across schools...
March 20, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
Mario Rotondi, Valentina Capelli, Francesca Coperchini, Sara Pinto, Laura Croce, Massimo Tonacchera, Luca Chiovato
DESIGN: Graves' disease (GD) patients in remission after a full course of methimazole (MMI) therapy are at risk for a relapse of hyperthyroidism during the post-partum (PP) period, but whether this relapse may display any peculiarity is still unknown. Aim of this study was to compare GD patients undergoing a relapse of hyperthyroidism either in the PP period or not. METHODS: We retrospectively evaluated fourty-three GD female patients in their childbearing age who experienced a relapse of hyperthyroidism...
March 20, 2018: European Journal of Endocrinology
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