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https://www.readbyqxmd.com/read/28062304/duplication-of-dio3-genes-in-teleost-fish-and-their-divergent-expression-in-skin-during-flatfish-metamorphosis
#1
R N Alves, J C R Cardoso, T Harboe, R S T Martins, M Manchado, B Norberg, D M Power
Deiodinase 3 (Dio3) plays an essential role during early development in vertebrates by controlling tissue thyroid hormone (TH) availability. The Atlantic halibut (Hippoglossus hippoglossus) possesses duplicate dio3 genes (dio3a and dio3b). Expression analysis indicates that dio3b levels change in abocular skin during metamorphosis and this suggests that this enzyme is associated with the divergent development of larval skin to the juvenile phenotype. In larvae exposed to MMI, a chemical that inhibits TH production and blocks metamorphosis, expression of dio3b in ocular skin is significantly up-regulated suggesting that THs normally modulate this genes expression during this developmental event...
January 3, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28042986/association-between-mastication-and-cognitive-status-a-systematic-review
#2
REVIEW
Akio Tada, Hiroko Miura
PURPOSE: A substantial number of elderly people suffer from cognitive impairment and dementia, which are considered to have various risk factors, including masticatory dysfunction; however, the association between mastication and cognition is inconclusive. The objectives of this systematic review were to provide an overview of the literature on (1) the association between mastication and cognitive function and (2) the association between mastication and dementia incidence, in elderly people...
December 14, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28034801/testing-the-correlation-between-experimentally-induced-hypothyroidism-during-pregnancy-and-autistic-like-symptoms-in-the-rat-offspring
#3
Francesca Melancia, Michela Servadio, Sara Schiavi, Patrizia Campolongo, Alexandre Giusti-Paiva, Viviana Trezza
Thyroid hormones are important for the development of the central nervous system. Since the fetal thyroid gland is not functioning until mid-gestation, transport of maternal thyroid hormones across the placenta is essential during the early phases of gestation. Maternal thyroid deficiency has been associated with a higher incidence of neurodevelopmental disorders in the newborns. The relationship between maternal hypothyroidism and the onset of autism spectrum disorders (ASD) in the offspring, however, is still debated...
December 26, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/28024976/neurological-functional-outcomes-of-decompressive-hemicraniectomy-versus-conventional-treatment-for-malignant-middle-cerebral-artery-infarction-a-systematic-review-and-mata-analysis
#4
Yu-Ping Li, Meng-Zhuo Hou, Guang-Yu Lu, Natalia Ciccone, Xing-Dong Wang, Lun Dong, Chen Cheng, Heng-Zhu Zhang
BACKGROUND: This study aims to evaluate the effect of decompressive hemicraniectomy (DHC) versus conventional treatments (CT) for patients with malignant middle cerebral artery infarction (MMI), and to investigate the impact of age and surgical timing on neurological function and mortality. METHODS: We searched English and Chinese databases for randomized controlled trials (RCTs) or observational studies (OSs) published before August 2016. The outcomes included good functional outcome (GFO), mortality, National Institutes of Health Stroke Scale (NIHSS) score, and Barthel Index (BI) score...
December 23, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28024439/impact-of-sociodemographic-characteristics-of-applicants-in-multiple-mini-interviews
#5
Jean-Michel Leduc, Richard Rioux, Robert Gagnon, Christian Bourdy, Ashley Dennis
BACKGROUND: Multiple mini-interviews (MMI) are commonly used for medical school admission. This study aimed to assess if sociodemographic characteristics are associated with MMI performance, and how they may act as barriers or enablers to communication in MMI. METHODS: This mixed-method study combined data from a sociodemographic questionnaire, MMI scores, semi-structured interviews and focus groups with applicants and assessors. Quantitative and qualitative data were analyzed using multiple linear regression and a thematic framework analysis...
December 26, 2016: Medical Teacher
https://www.readbyqxmd.com/read/28004374/individual-differences-in-media-multitasking-and-performance-on-the-n-back
#6
Brandon C W Ralph, Daniel Smilek
A number of studies have recently examined the link between individual differences in media multitasking (using the MMI) and performance on working memory paradigms. However, these studies have yielded mixed results. Here we examine the relation between media multitasking and one particular working memory paradigm-the n-back (2- and 3-back)-improving upon previous research by (a) treating media multitasking as a continuous variable and adopting a correlational approach as well as (b) using a large sample of participants...
December 21, 2016: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/27978464/selectivity-evaluation-and-separation-of-human-immunoglobulin-g-fab-and-fc-fragments-with-mixed-mode-resins
#7
Ying-Di Luo, Qi-Lei Zhang, Xiao-Ming Yuan, Wei Shi, Shan-Jing Yao, Dong-Qiang Lin
Adsorption selectivity is critical important for mixed-mode chromatography with specially-designed ligands. Human immunoglobulin G (hIgG), Fc and Fab fragments were used in the present work to evaluate adsorption behavior and binding selectivity of four mixed-mode resins with the ligands of 4-mercatoethyl-pyridine (MEP), 2-mercapto-1-methylimidazole (MMI), 5-aminobenzimidazole (ABI) and tryptophan-5-aminobenzimidazole (W-ABI), respectively. The resins showed an obvious pH-dependent adsorption behavior. High adsorption capacities were found at neutral pH for hIgG, Fc and Fab, and almost no adsorption happened under acidic conditions...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27966092/attitudes-of-patients-and-relatives-toward-disability-and-treatment-in-malignant-mca-infarction
#8
Hermann Neugebauer, Matthias Schnabl, Dorothée Lulé, Peter U Heuschmann, Eric Jüttler
BACKGROUND: Attitudes among patients and relatives toward the degree of acceptable disability and the importance of aphasia are critical in deciding on decompressive hemicraniectomy (DHC) in malignant middle cerebral artery infarction (MMI). However, most MMI patients are not able to communicate their will. Furthermore, attitudes of healthy individuals and relatives may not correspond to those of stroke patients. METHODS: This is a multicenter survey among 355 patients and 199 relatives during treatment for acute minor or moderate severe ischemic stroke in Germany...
December 13, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27940353/white-matter-damage-and-glymphatic-dysfunction-in-a-model-of-vascular-dementia-in-rats-with-no-prior-vascular-pathologies
#9
Poornima Venkat, Michael Chopp, Alex Zacharek, Chengcheng Cui, Li Zhang, Qingjiang Li, Mei Lu, Talan Zhang, Amy Liu, Jieli Chen
We investigated cognitive function, axonal/white matter (WM) changes and glymphatic function of vascular dementia using a multiple microinfarction (MMI) model in retired breeder (RB) rats. The MMI model induces significant (p < 0.05) cognitive decline that worsens with age starting at 2 weeks, which persists until at least 6 weeks after MMI. RB rats subjected to MMI exhibit significant axonal/WM damage identified by decreased myelin thickness, oligodendrocyte progenitor cell numbers, axon density, synaptic protein expression in the cortex and striatum, cortical neuronal branching, and dendritic spine density in the cortex and hippocampus compared with age-matched controls...
February 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/27925837/a-comprehensive-multimorbidity-index-for-predicting-mortality-in-intensive-care-unit-patients
#10
Hua Min, Sanja Avramovic, Janusz Wojtusiak, Rahul Khosla, Ross D Fletcher, Farrokh Alemi, Raya Elfadel Kheirbek
BACKGROUND: Accurate prediction of mortality for patients admitted to the intensive care units (ICUs) is an important component of medical care. However, little is known about the role of multimorbidity in predicting end of life for high-risk and vulnerable patients. OBJECTIVE: The aim of the study was to derive and validate a multimorbidity risk model in an attempt to predict all-cause mortality at 6 and 12 months posthospital discharge. METHODS: This is a retrospective, observational, clinical cohort study...
January 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27925606/increasing-awareness-and-acceptance-through-mindfulness-and-somatic-education-movements
#11
Paulo Vicente Bloise, Mário César Rezende Andrade, Hans Machado, Sérgio Baxter Andreoli
Context • The main feature of mindfulness-based interventions (MBI) is the encouragement of present moment awareness and of self-regulation, which are associated with health benefits. Meditating with the body in movement has been referred to as one of the most accessible ways of reaching such awareness. An MBI program, Mindfulness and Movements of Integration (MMI), has the same structure as mindfulness-based stress reduction (MBSR) but puts more emphasis on the body and uses somatic education (SE) movements instead of yoga postures...
October 2016: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/27909365/interviewers-experiences-with-two-multiple-mini-interview-scoring-methods-used-for-admission-to-a-master-of-physical-therapy-programme
#12
Ina van der Spuy, Angela Busch, Julia Bidonde
Purpose: To describe participants' attitudes, beliefs, and experiences with the use of two methods of scoring the Multiple Mini-Interview (MMI) for admission to a Master of Physical Therapy program: a rank-based scoring system (RBS; used from 2007 to 2013) and a criterion-based scoring system (CBS; tested in 2014). The MMI uses short independent assessments to obtain an aggregate score of candidates' professionalism and interpersonal skills, based on behavioural questions within scenarios that assess one attribute at a time...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27905663/identifying-applicants-suitable-to-a-career-in-nursing-a-value-based-approach-to-undergraduate-selection
#13
Marian Traynor, Despina Galanouli, Martin Roberts, Lawrence Leonard, Thomas Gale
AIMS: The aim of this study was to complement existing evidence on the suitability of Multiple Mini Interviews as a potential tool for the selection of nursing candidates on to a BSc (Hons) nursing programme. BACKGROUND: This study aimed to trial the Multiple Mini Interview approach to recruitment with a group of first year nursing students (already selected using traditional interviews). DESIGN: Cross-sectional validation study. This paper reports on the evaluation of the participants' detailed scores from the Multiple Mini Interview stations; their original interview scores and their end of year results...
December 1, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27904672/t3-inhibits-the-calcification-of-vascular-smooth-muscle-cells-and-the-potential-mechanism
#14
Xiaodan Chang, Baohong Zhang, Li Lihua, Zhichun Feng
OBJECTIVE: This study aimed to investigate the potential molecular mechanism underlying the T3 induced vascular calcification and phenotype transformation of vascular smooth muscle cells (VSMCs). METHODS: Rat thoracic aortic smooth muscle cells (A7r5) were cultured in vitro and randomly assigned into normal control group, calcification group, T3 group and inhibitor group. RESULTS: When compared with normal control group, the osteocalcin content, ALP activity, Osterix and Runx2 mRNA expression and OPN protein expression increased significantly (P<0...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27875237/automatic-facial-expression-recognition-system-using-deep-network-based-data-fusion
#15
Anima Majumder, Laxmidhar Behera, Venkatesh K Subramanian
This paper presents a novel automatic facial expressions recognition system (AFERS) using the deep network framework. The proposed AFERS consists of four steps: 1) geometric features extraction; 2) regional local binary pattern (LBP) features extraction; 3) fusion of both the features using autoencoders; and 4) classification using Kohonen self-organizing map (SOM)-based classifier. This paper makes three distinct contributions. The proposed deep network consisting of autoencoders and the SOM-based classifier is computationally more efficient and performance wise more accurate...
November 17, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27866307/explicating-the-conditions-under-which-multilevel-multiple-imputation-mitigates-bias-resulting-from-random-coefficient-dependent-missing-longitudinal-data
#16
Nisha C Gottfredson, Sonya K Sterba, Kristina M Jackson
Random coefficient-dependent (RCD) missingness is a non-ignorable mechanism through which missing data can arise in longitudinal designs. RCD, for which we cannot test, is a problematic form of missingness that occurs if subject-specific random effects correlate with propensity for missingness or dropout. Particularly when covariate missingness is a problem, investigators typically handle missing longitudinal data by using single-level multiple imputation procedures implemented with long-format data, which ignores within-person dependency entirely, or implemented with wide-format (i...
January 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/27853063/successful-re-administration-of-low-dose-of-methimazole-mmi-in-graves-disease-patients-who-experienced-allergic-cutaneous-reactions-to-mmi-at-initial-treatment-and-had-received-long-term-propylthiouracil-ptu
#17
Sumihisa Kubota
Objective When patients with Graves' disease show severe allergic cutaneous reactions, physicians often suggest that they undergo radioiodine therapy instead of receiving propylthiouracil (PTU), another antithyroid drug, because anti-neutrophil cytoplasmic antibody (ANCA) -related vasculitis can occur with PTU, especially with long-term use. However, some patients refuse radioiodine therapy and chose PTU. Sometimes PTU treatment may be prolonged. Since the frequency of adverse effects of methimazole (MMI) is dose-related, there is a possibility that we can re-administer a low dose without adverse effects to patients well-controlled with PTU who once experienced an allergic reaction to MMI...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27832996/quercetin-changes-purinergic-enzyme-activities-and-oxidative-profile-in-platelets-of-rats-with-hypothyroidism
#18
Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Daniela Zanini, Andréia M Cardoso, Fátima H Abadalla, Gustavo R Thomé, Camila Murussi, Carla R N Polachini, Diéssica P Delenogare, Vania L Loro, Vera M Morsch, Maria R C Schetinger
Diseases related to thyroid hormones have been extensively studied because affect a large number of individuals, and these hormones participate in the regulation of the whole organism homeostasis. However, little is known about the involvement of purinergic signaling related to oxidative stress in hypothyroidism and possible therapeutic adjuncts for treatment of this disorder. Thus, the present study investigates the effects of quercetin on NTPDase, 5'-nucleotidase and adenosine deaminase activities, platelet aggregation and oxidative profile in platelets of rats with methimazole (MMI)-induced hypothyroidism...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27828321/analysis-of-multimode-interferometers
#19
Kieran Cooney, Frank H Peters
A general analytical formula describing the transfer function between the input and output of an arbitrary rectangular multimode interference (MMI) coupler has been derived using the elliptic theta function ϑ(x', z'). This formula provides the positions, amplitudes and relative phases of all the self-images of a given source. It is shown how the transfer function can be used as a propagation matrix for any rectangular NxM MMI. Specific simplified solutions for NxN, symmetric and paired MMIs are also derived from the general formula...
October 3, 2016: Optics Express
https://www.readbyqxmd.com/read/27803210/can-multiple-mini-interviews-predict-academic-performance-of-dental-students-a-two-year-follow-up
#20
Sumer M Alaki, Ibrahim A Yamany, Lana A Shinawi, Mona H A Hassan, Ara Tekian
Prior research has shown that students' previous grade point average (GPA) is the best predictor for future academic success. However, it can only partly predict the variability in dental school performance. The aim of this study was to assess the predictive value of multiple mini-interviews (MMI) as an admission criterion by comparing them with the academic performance of dental students over a two-year period. All incoming undergraduate dental students at the King Abdulaziz University Faculty of Dentistry (KAUFD) during academic year 2013-14 were invited to participate in MMI...
November 2016: Journal of Dental Education
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