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https://www.readbyqxmd.com/read/28799288/neuroprotective-activity-of-cannabinoid-receptor-2-against-oxidative-stress-and-apoptosis-in-rat-pups-having-experimentally-induced-congenital-hypothyroidism
#1
Mehmet Eray Alcigir, Halef Okan Dogan, Sevil Atalay Vural, Fatma Meriç Yilmaz
In this study, it was aimed to show the cannabinoid receptor-2 (CB2) role, which is a part of neuroprotective endocannabinoidal system, against increasing nitric oxide synthetase (iNOS, eNOS) levels and the apoptotic activity (caspase-3, caspase-9 and DNA in situ fragmentation) within the postnatal critical period in pups of pregnant rats with artificially induced maternal thyroid hormone (TH) deficiency. Each of the 3 groups established comprised 1 male and 2 female rats, and they were coupled. Their pups were used...
August 11, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28798267/pretreatment-predictors-of-malignant-evolution-in-patients-with-ischemic-stroke-undergoing-mechanical-thrombectomy
#2
Alessandro Davoli, Caterina Motta, Giacomo Koch, Marina Diomedi, Simone Napolitano, Angela Giordano, Marta Panella, Daniele Morosetti, Sebastiano Fabiano, Roberto Floris, Roberto Gandini, Fabrizio Sallustio
BACKGROUND: Few data exist on malignant middle cerebral artery infarction (MMI) among patients with acute ischemic stroke (AIS) after endovascular treatment (ET). Numerous predictors of MMI evolution have been proposed, but a comprehensive research of patients undergoing ET has never been performed. Our purpose was to find a practical model to determine robust predictors of MMI in patients undergoing ET. METHODS: Patients from a prospective single-center database with AIS secondary to large intracranial vessel occlusion of the anterior circulation, treated with ET, were retrospectively analyzed...
August 10, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28780518/birth-defects-after-use-of-antithyroid-drugs-in-early-pregnancy-a-swedish-nationwide-study
#3
Stine Linding Andersen, Stefan Lönn, Peter Vestergaard, Ove Törring
OBJECTIVE: Antithyroid drugs (ATDs) may have teratogenic effects, but more evidence is needed on the risk and types of birth defects after the use of Methimazole (MMI) and Propylthiouracil (PTU). This study aimed to evaluate the association between the use of ATDs in early pregnancy and birth defects. DESIGN: Swedish nationwide register-based cohort study. METHODS: The study included 684,340 children live-born in Sweden from 2006-2012. Exposure groups defined by maternal ATD use in early pregnancy were: MMI (n=162); PTU (n=218); MMI and PTU (n=66); ATD before or after, but not in pregnancy (n=1,551); and non-exposed (never ATD (n=682,343))...
August 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28774006/an-8-channel-wavelength-mmi-demultiplexer-in-slot-waveguide-structures
#4
Bar Baruch Ben Zaken, Tal Zanzury, Dror Malka
We propose a novel 8-channel wavelength multimode interference (MMI) demultiplexer in slot waveguide structures that operate at 1530 nm, 1535 nm, 1540 nm, 1545 nm, 1550 nm, 1555 nm, 1560 nm, and 1565 nm. Gallium nitride (GaN) surrounded by silicon (Si) was found to be a suitable material for the slot-waveguide structures. The proposed device was designed by seven 1 × 2 MMI couplers, fourteen S-bands, and one input taper. Numerical investigations were carried out on the geometrical parameters using a full vectorial-beam propagation method (FV-BPM)...
November 1, 2016: Materials
https://www.readbyqxmd.com/read/28767416/effect-of-subclinical-hypothyroidism-on-the-skeletal-system-and-improvement-with-short-term-thyroxine-therapy
#5
Cuixia Gao, Yu Wang, Tingting Li, Jing Huang, Limin Tian
The purpose of the study was to observe changes in the skeletal system of rats with subclinical hypothyroidism (SCH) and to determine whether L-thyroxine (L-T4) administration suppresses those changes. Sixty male Wistar rats were randomly divided into control, SCH, and SCH+T4 groups. SCH was induced in rats by administration of methimazole (MMI), and rats in the SCH+T4 group were treated with L-T4 after 45 days of MMI administration. The SCH group had higher thyroid-stimulating hormone (TSH) level than the control and SCH+T4 groups...
July 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28766137/inhaled-glucocorticoids-are-associated-with-vertebral-fractures-in-copd-patients
#6
Pedro Assed Gonçalves, Rafael Dos Santos Neves, Leonardo Vieira Neto, Miguel Madeira, Fernando Silva Guimarães, Laura Maria Carvalho Mendonça, Agnaldo Jose Lopes, Maria Lucia Fleiuss Farias
Chronic obstructive pulmonary disease (COPD) is an independent risk factor for osteoporosis. Oral glucocorticoids are deleterious to bone; however, the impact of inhaled glucocorticoids (ICS) remains unclear. Our objective was to determine whether ICS contribute to osteoporosis and fragility fractures. Sixty-one COPD patients, 35 current users of ICS and 26 who had never received glucocorticoids, were evaluated for bone mineral density (BMD) and body composition and underwent vertebral fracture assessment (VFA)...
August 1, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28750229/improving-assessment-accuracy-for-lake-biological-condition-by-classifying-lakes-with-diatom-typology-varying-metrics-and-modeling-multimetric-indices
#7
Bo Liu, R Jan Stevenson
Site grouping by regions or typologies, site-specific modeling and varying metrics among site groups are four approaches that account for natural variation, which can be a major source of error in ecological assessments. Using a data set from the 2007 National Lakes Assessment project of the USEPA, we compared performances of multimetric indices (MMI) of biological condition that were developed: (1) with different lake grouping methods, ecoregions or diatom typologies; (2) by varying or not varying metrics among site groups; and (3) with different statistical techniques for modeling diatom metric values expected for minimally disturbed condition for each lake...
July 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28723125/pharmacokinetics-on-a-chip-using-label-free-sers-technique-for-programmable-dual-drug-analysis
#8
Jiayuan Fei, Lei Wu, Yizhi Zhang, Shenfei Zong, Zhuyuan Wang, Yiping Cui
Synergistic effects of dual or multiple drugs have attracted great attention in medical fields, especially in cancer therapies. We provide a programmable microfluidic platform for pharmacokinetic detection of multiple drugs in multiple cells. The well-designed microfluidic platform includes two 2 × 3 microarrays of cell chambers, two gradient generators, and several pneumatic valves. Through the combined use of valves and gradient generators, each chamber can be controlled to infuse different kinds of living cells and drugs with specific concentrations as needed...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28713502/the-effect-of-personality-traits-on-undergraduate-dental-students-performance-in-multiple-mini-interviews
#9
Lana Ahmed Shinawi, Sumer Madani Alaki, Ibrahim Yamany, Mona Hassan Ahmed Hassan
BACKGROUND: Multiple mini interviews (MMI) is a structured student selection method where applicants rotate around a series of stations that do not require previously learned knowledge. The Big Five Inventory (BFI) is a tool often used to measure personality traits commonly used in applicant selection. OBJECTIVE: The aim of the current study was to assess the effect of personality traits using the BFI on undergraduate dental students' performance in MMI. METHODS: This research was conducted at The Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28690285/myocardial-bridges-on-coronary-computed-tomography-angiography%C3%A3-correlation-with-intravascular-ultrasound-and-fractional-flow-reserve
#10
Signe Helene Forsdahl, Ian S Rogers, Ingela Schnittger, Shigemitsu Tanaka, Takumi Kimura, Vedant S Pargaonkar, Frandics P Chan, Dominik Fleischmann, Jennifer A Tremmel, Hans-Christoph Becker
BACKGROUND: Myocardial bridges (MB) are commonly seen on coronary CT angiography (CCTA) in asymptomatic individuals, but in patients with recurrent typical angina symptoms, yet no obstructive coronary artery disease (CAD), evaluation of their potential hemodynamic significance is clinically relevant. The aim of this study was to compare CCTA to invasive coronary angiography (ICA), including intravascular ultrasound (IVUS), to confirm MB morphology and estimate their functional significance in symptomatic patients...
July 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28681649/first-experience-with-multiple-mini-interview-for-medical-school-admission-in-brazil-does-it-work-in-a-different-cultural-scenario
#11
Durval Anibal Daniel-Filho, Elda Maria Stafuzza Gonçalves Pires, Angela Tavares Paes, Eduardo Juan Troster, Simone Cristina Azevedo B S Silva, Mariana Fachini Granato, Thomaz Bittencourt Couto, Joyce Kelly Silva Barreto, Alexandre Holthausen Campos, Julio C Martins Monte, Claudio Schvartsman
PURPOSE: Evaluation of non-cognitive skills never has been used in Brazil. This study aims to evaluate Multiple Mini Interviews (MMI) in the admission process of a School of Medicine in São Paulo, Brazil. METHODS: The population of the study comprised 240 applicants summoned for the interviews, and 96 raters. MMI contributed to 25% of the applicants' final grade. Eight scenarios were created with the aim of evaluating different non-cognitive skills, each one had two raters...
July 6, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28671971/effects-of-methimazole-and-propylthiouracil-exposure-during-pregnancy-on-the-risk-of-neonatal-congenital-malformations-a-meta-analysis
#12
Rongjing Song, Hepu Lin, Yue Chen, Xiuying Zhang, Wanyu Feng
OBJECTIVE: The aim of this study was to determine the effect of exposure to different antithyroid drugs during pregnancy on the incidence of neonatal congenital malformations. METHODS: A meta-analysis was performed to compare the incidence of neonatal congenital malformations after exposure to different antithyroid drugs during pregnancy. Twelve studies that met the inclusion criteria were included in this meta-analysis. PubMed, Embase, and CENTRAL databases were searched from inception until January 2017...
2017: PloS One
https://www.readbyqxmd.com/read/28657226/factors-associated-with-survival-after-relapse-in-patients-with-low-risk-endometrial-cancer-treated-with-surgery-alone
#13
Nazli Topfedaisi Ozkan, Mehmet Mutlu Meydanlı, Mustafa Erkan Sarı, Fuat Demirkiran, Ilker Kahramanoglu, Tugan Bese, Macit Arvas, Hanifi Şahin, Ali Haberal, Husnu Celik, Gonca Coban, Tufan Oge, Omer Tarik Yalcin, Özgür Akbayır, Baki Erdem, Ceyhun Numanoğlu, Nejat Özgül, Gökhan Boyraz, Mehmet Coşkun Salman, Kunter Yüce, Murat Dede, Mufit Cemal Yenen, Salih Taşkın, Duygu Altın, Uğur Fırat Ortaç, Hülya Aydın Ayık, Tayup Şimşek, Tayfun Güngör, Kemal Güngördük, Muzaffer Sancı, Ali Ayhan
OBJECTIVE: To determine factors influencing overall survival following recurrence (OSFR) in women with low-risk endometrial cancer (EC) treated with surgery alone. METHODS: A multicenter, retrospective department database review was performed to identify patients with recurrent "low-risk EC" (patients having less than 50% myometrial invasion [MMI] with grade 1 or 2 endometrioid EC) at 10 gynecologic oncology centers in Turkey. Demographic, clinicopathological, and survival data were collected...
September 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28642018/clinical-study-of-27-patients-with-medial-medullary-infarction
#14
Takayoshi Akimoto, Katsuhiko Ogawa, Akihiko Morita, Yutaka Suzuki, Satoshi Kamei
BACKGROUND: Medial medullary infarction (MMI) is a rare ischemic stroke. Frequency of each neurological finding in MMI was different in each study. METHODS: We retrospectively evaluated the medical records of patients with cerebral infarction who were admitted between March 1998 and October 2015. Patients in our study were diagnosed as having MMI by magnetic resonance image examination. RESULTS: Of 2727 patients with ischemic stroke, 27 patients (20 males and 7 females) had MMI...
June 20, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28639966/risk-of-embryopathies-with-use-of-antithyroidal-medications
#15
Stine L Andersen
PURPOSE OF REVIEW: Hyperthyroidism in pregnant women should be adequately treated to prevent maternal and fetal complications. The treatment of choice in pregnancy is antithyroidal medications (ATDs). The risk of embryopathies associated with the use of Methimazole (MMI) and Propylthiouracil (PTU) in early pregnancy is a matter of clinical attention and concern. This review describes current evidence and how scientific findings are reflected in current clinical guidelines. RECENT FINDINGS: Embryopathies after the use of ATDs were previously mainly described in case reports and considered rare...
July 20, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28630718/ability-to-return-to-work-without-restrictions-in-workers-compensation-patients-undergoing-hip-arthroscopy
#16
Simon Lee, Gregory L Cvetanovich, Randy Mascarenhas, Thomas H Wuerz, Richard C Mather, Charles A Bush-Joseph, Shane J Nho
The purpose of this study was to investigate the ability of worker's compensation (WC) patients to return to work without restrictions after hip arthroscopy. Twenty-nine WC patients along with age and gender matched controls who underwent hip arthroscopy were retrospectively reviewed after achieving maximum medical improvement (MMI) status at minimum 1 year postoperatively. Patient demographic factors were evaluated, along with the Hip Outcome Score Activities of Daily Living and Sports-Specific subscales, and the modified Harris Hip Score (mHHS)...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28623911/moderate-mental-illness-as-a-predictor-of-chronic-disease-prevention-and-screening
#17
Ginetta Salvalaggio, Christopher Meaney, Rahim Moineddin, Eva Grunfeld, Donna Manca
BACKGROUND: Primary care plays a pivotal role in the provision of both mental health care and chronic disease prevention and screening (CDPS). Unfortunately, moderate mental illness (MMI) is associated with poorer general health outcomes. Part of this burden of illness may be due to reduced CDPS uptake. The Building on the Existing Tools to Improve Chronic Disease Prevention in Primary Care (BETTER) trial recruited 777 participants ages 40-65 from 32 family practice panels, of whom 135 (18...
June 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28608527/perfect-storm-therapeutic-plasma-exchange-for-a-patient-with-thyroid-storm
#18
Andrea M McGonigle, Aaron A R Tobian, Jennifer L Zink, Karen E King
Thyroid storm is a potentially lethal complication of hyperthyroidism with increased thyroid hormones and exaggerated symptoms of thyrotoxicosis. First-line therapy includes methimazole (MMI) or propylthiouracil (PTU) to block production of thyroid hormones as a bridge toward definitive surgical treatment. Untreated thyroid storm has a mortality rate of up to 30%; this is particularly alarming when patients cannot tolerate or fail pharmacotherapy, especially if they cannot undergo thyroidectomy. Therapeutic plasma exchange (TPE) is an ASFA category III indication for thyroid storm, meaning the optimum role of this therapy is not established, and there are a limited number of cases in the literature...
June 13, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28604451/is-tumor-size-really-important-for-prediction-of-lymphatic-dissemination-in-grade-1-endometrial-carcinoma-with-superficial-myometrial-invasion
#19
Murat Oz, Vakkas Korkmaz, Mehmet Mutlu Meydanli, Mustafa Erkan Sari, Zeliha Firat Cuylan, Tayfun Gungor
OBJECTIVES: Selection of patients with endometrioid endometrial cancer (EEC), in whom systematic lymph node dissection (LND) is indicated, is an important part of management to maintain optimal oncological outcomes, while avoiding unnecessary morbidities. According to the current approach, LND is recommended for the patients with International Federation of Gynecology and Obstetrics (FIGO) grade 1 to 2 tumors and a primary tumor diameter (PTD) greater than 2 cm, even with myometrial invasion (MMI) of less than 50%...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28601913/the-effects-of-a-non-cognitive-versus-cognitive-admission-procedure-within-cohorts-in-one-medical-school
#20
Marieke de Visser, Cornelia Fluit, Janke Cohen-Schotanus, Roland Laan
In medical school selection, non-cognitive performance in particular correlates with performance in clinical practice. It is arguable, therefore, that selection should focus on non-cognitive aspects despite the predictive value of prior cognitive performance for early medical school performance. The aim of this study at Radboud University Medical Center, the Netherlands, is to determine the effects of admitting students through an autonomous non-cognitive procedure on early medical school performance. We compared their performance to the performance of students selected through an autonomous cognitive selection procedure, enrolling in the Bachelor's curriculum simultaneously...
June 10, 2017: Advances in Health Sciences Education: Theory and Practice
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