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Akira Honda, Toyoyoshi Uchida, Koji Komiya, Hiromasa Goto, Kageumi Takeno, Junko Sato, Ruriko Suzuki, Miwa Himuro, Hirotaka Watada
OBJECTIVE: Inorganic iodine is often used to treat patients with Graves' thyrotoxicosis who do not tolerate thionamides due to adverse effects. However, predictors of continued inorganic iodine efficacy have not been fully elucidated yet. This study aimed to investigate the factors affecting the continued efficacy of potassium iodide (KI) in patients with Graves' thyrotoxicosis. METHODS: In this study, among 1197 patients with Graves' disease who were initially treated with thionamides, we retrospectively studied 24 consecutive Japanese patients whose treatment were changed to KI alone due to the adverse effects of thionamides...
November 16, 2017: Endocrine Practice
L P L Matos, R Cortez-Cardoso, L C Cardoso-Weide, M L Freitas, D L S G Silva, A C F Ferreira
Na(+) /I(-) symporter (NIS) transports iodide into thyrocytes, a fundamental step for thyroid hormone biosynthesis. Our aim was to evaluate NIS regulation in different status of goitrogenesis and its underlying mechanisms. Wistar rats were treated with methimazole (MMI) for 5 and 21 days, to achieve different status of goiter. We then evaluated the effect of MMI removal for 1 day (R1d), after 5 (R1d-5d) or 21 (R1d-21d) days of MMI treatment. MMI increased thyroid weight, iodide uptake and in vitro TPO activity in a time-dependent way...
November 7, 2017: Clinical and Experimental Pharmacology & Physiology
Anthony Jerant, Mark C Henderson, Erin Griffin, Julie A Rainwater, Theodore R Hall, Carolyn J Kelly, Ellena M Peterson, David Wofsy, Peter Franks
BACKGROUND: Many medical schools use admissions Multiple Mini-Interviews (MMIs) rather than traditional interviews (TIs), partly because MMIs are thought to be more reliable. Yet prior studies examined single-school samples of candidates completing either an MMI or TI (not both). Using data from five California public medical schools, the authors examined the within- and between-school reliabilities of TIs and MMIs. METHODS: The analyses included applicants interviewing at ≥1 of the five schools during 2011-2013...
November 6, 2017: BMC Medical Education
Amy Godfrey, Blair Hooser, Ahmed Abdelmoneim, Katharine A Horzmann, Jennifer L Freemanc, Maria S Sepúlveda
Endocrine disrupting chemicals (EDCs) can alter thyroid function and adversely affect growth and development. Halogenated compounds, such as perfluorinated chemicals commonly used in food packaging, and brominated flame retardants used in a broad range of products from clothing to electronics, can act as thyroid disruptors. Due to the adverse effects of these compounds, there is a need for the development of safer next generation chemicals. The objective of this study was to test the thyroid disruption potential of old use and next generation halogenated chemicals...
October 28, 2017: Aquatic Toxicology
Harold Reiter, Kevin Eva
The literature on multiple mini-interviews (MMIs) is replete with heterogeneous study results related to the constructs measured, correlations with other measures, and demographic relationships. Rather than view these results as contradictory, the authors ask, What if all of the results are correct? They point out that the MMI is not an assessment tool, but rather an assessment method. Design and implementation of locally conducted MMIs in medical school admissions processes should reflect local needs. As with other local assessments, MMIs should be considered separate from nationally conducted assessments that reflect more universal competencies...
October 31, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
Mark C Henderson, Carolyn J Kelly, Erin Griffin, Theodore R Hall, Anthony Jerant, Ellena M Peterson, Julie A Rainwater, Francis J Sousa, David Wofsy, Peter Franks
PURPOSE: To examine applicant characteristics associated with multi mini-interview (MMI) or traditional interview (TI) performance at five California public medical schools. METHOD: Of the five California Longitudinal Evaluation of Admissions Practices (CA-LEAP) consortium schools, three used TIs and two used MMIs. Schools provided the following retrospective data on all 2011-2013 admissions cycle interviewees: age, gender, race/ethnicity (under-represented in medicine [UIM] or not), self-identified disadvantaged (DA) status, undergraduate GPA, Medical College Admission Test (MCAT) score, and interview score (standardized as z-score, mean = 0, SD = 1)...
October 31, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
Thalía Domínguez Bucio, Ali Z Khokhar, Goran Z Mashanovich, Frederic Y Gardes
WDM components fabricated on the silicon-on-insulator platform have transmission characteristics that are sensitive to dimensional errors and temperature variations due to the high refractive index and thermo-optic coefficient of Si, respectively. We propose the use of NH3-free SiNx layers to fabricate athermal (de)multiplexers based on angled multimode interferometers (AMMI) in order to achieve good spectral responses with high tolerance to dimensional errors. With this approach we have shown that stoichiometric and N-rich SiNx layers can be used to fabricate AMMIs with cross-talk <30dB, insertion loss <2...
October 30, 2017: Optics Express
George J Kahaly, Michaela Riedl, Jochem König, Tanja Diana, Lutz Schomburg
Context: Supplemental selenium (Se) may affect the clinical course of Graves disease (GD). Objective: Evaluate efficacy of add-on Se on medical treatment in GD. Design: Double-blind, placebo-controlled, randomized supplementation trial. Setting: Academic endocrine outpatient clinic. Patients: Seventy untreated hyperthyroid patients with GD. Intervention: Additionally to methimazole (MMI), patients received for 24 weeks either sodium selenite 300 µg/d po or placebo...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
Alison Callwood, Debbie Cooke, Sarah Bolger, Agnieszka Lemanska, Helen Allan
BACKGROUND: Universities in the United Kingdom (UK) are required to incorporate values based recruitment (VBR) into their healthcare student selection processes. This reflects an international drive to strengthen the quality of healthcare service provision. This paper presents novel findings in relation to the reliability and predictive validity of multiple mini interviews (MMIs); one approach to VBR widely being employed by universities. OBJECTIVES: To examine the reliability (internal consistency) and predictive validity of MMIs using end of Year One practice outcomes of under-graduate pre-registration adult, child, mental health nursing, midwifery and paramedic practice students...
October 6, 2017: International Journal of Nursing Studies
Jean-Sébastien Renaud, Luc Côté
BACKGROUND: Medical students on clinical rotations have to be assessed on several competencies at the end of each clinical rotation, pointing to the need for short, reliable, and valid assessment instruments of each competency. Doctor patient communication is a central competency targeted by medical schools however, there are no published short (i.e. less than 10 items), reliable and valid instruments to assess doctor-patient communication competency. The Faculty of Medicine of Laval University recently developed a 5-item Doctor-Patient Communication Competency instrument for Medical Students (DPCC-MS), based on the Patient Centered Clinical Method conceptual framework, which provides a global summative end-of-rotation assessment of doctor-patient communication...
October 26, 2017: BMC Medical Education
H Ahmad, A S Sharbirin, M Z Samion, M F Ismail
A compact all-fiber multimode interferometer (MMI) designed to produce a switchable multi-wavelength thulium-doped fiber laser (TDFL) is proposed and demonstrated. The TDFL fiber ring cavity employs a 60-cm-long multimode fiber into the cavity to induce multimode interference and provide intensity-dependent loss in order to generate a multi-wavelength output. The suppression of mode competition and the overall stability of the TDFL are further improved by exploiting the filtering capability of a Sagnac loop...
July 20, 2017: Applied Optics
Jeong Hwan Song, Tangla D Kongnyuy, Naser Hosseini, Pieter Neutens, Federico Buja, Roelof Jansen, Xavier Rottenberg
Compact wavelength splitters based on angled multimode interferometers (AMMIs) on silicon nitride platforms working in visible lights are reported for fluorescence sensing applications. A diplexer and triplexer with different footprints are designed and experimentally demonstrated. The diplexer and triplexer have the insertion loss of ∼1.7 and ∼2.7  dB/channel with cross talks of less than -22  dB and -17  dB on target wavelengths, respectively. These splitters are used to distinguish the signals collected from two fluorescent dyes that give different emission spectra when excited with an excitation source, due to their different Stokes shifts...
October 10, 2017: Applied Optics
Guan-Lin Su, Ming C Wu
We present a comprehensive study for a new three-branch widely tunable semiconductor laser based on a self-imaging, lossless multi-mode interference (MMI) coupler. We have developed a general theoretical framework that is applicable to all types of interferometric lasers. Our analysis showed that the three-branch laser offers high side-mode suppression ratios (SMSRs) while maintaining a wide tuning range and a low threshold modal gain of the lasing mode. We also present the design rules for tuning over the dense-wavelength division multiplexing grid over the C-band...
September 4, 2017: Optics Express
Guofang Fan, Regis Orobtchouk, Bing Han, Yuan Li, Hongyu Li
An integrated 8 x 8 wavelength router based on the micro-ring resonators using 2 x 2 multi-interference (MMI) crossing is demonstrated on silicon-on-insulator (SOI) technology, which is manufactured with microelectronics equipment. Experimental results show a free spectral range (FSR) about ~37 nm, an on/off contrast larger than 20 dB, an imbalance among the channels less than 2 dB, a crosstalk of channels smaller than -10 dB, a spacing between close channels about 3.6 ± 0.7 nm and an output efficiency of every channel smaller than 20 dB...
October 2, 2017: Optics Express
Wei Xu, Jia Shi, Xianchao Yang, Degang Xu, Feng Rong, Junfa Zhao, Jianquan Yao
A relative humidity (RH) sensor based on single-mode-no-core-single-mode fiber (SNCS) structure is proposed and experimentally demonstrated. The agarose gel is coated on the no-core fiber (NCF) as the cladding, and multimode interference (MMI) occurs in the SNCS structure. The transmission spectrum of the sensor is modulated at different ambient relative humidities due to the tunable refractive index property of the agarose gel film. The relative humidity can be measured by the wavelength shift and intensity variation of the dip in the transmission spectra...
October 16, 2017: Sensors
Diletta Piccirilli, Enke Baldini, Micol Massimiani, Antonella Camaioni, Antonietta Salustri, Roberta Bernardini, Marco Centanni, Salvatore Ulisse, Constanzo Moretti, Luisa Campagnolo
A clinical association between thyroid dysfunction and pregnancy complications has been extensively reported, however the molecular mechanisms through which TH might regulate key-events of pregnancy have not been elucidated yet. In this respect, we performed in vivo studies in MMI- induced hypothyroid pregnant mice, evaluating the effect of hypothyroidism on the number of implantation sites, developing embryos/resorptions and pups per litter, at 4.5, 10.5, 18.5 days post coitum (dpc) and at birth. We also studied the expression of major molecules involved in implantation and placentation, such as the proteases ISPs, MMPs, TIMPs and Notch pathway related genes...
October 9, 2017: Journal of Endocrinology
О Bilchenko, V Kravtsova, Y Samburh, O Hodlevska, V Gavrilyuk
67 patients with CHF of FC II and concomitant chronic pyelonephritis at remission stage for not less than 6 months. As of the screening moment, intervention group (n=67 patients) and control group (n=22 apparently healthy individuals) were formed. The intervention group was divided into 3 groups: group 1 included 22 CHF patients with preserved LV EF (≥50%) associated with AH and concomitant CRD. Group 2 included 23 CHF patients with decreased heart LV EF (≤40%, but not less than 35%) associated with AH and concomitant CRD...
September 2017: Georgian Medical News
Monique Mangeon, Claudio Zett, Camila Amaral, Eduardo Novais, Cristina Muccioli, Gabriel Andrade, Heloisa Nascimento, Rubens Belfort
PURPOSE: To evaluate retinal and choroidal changes in patients with non-granulomatous choroiditis using the multimodality imaging (MMI). METHODS: Eight eyes of four patients were analyzed. Three patients (six eyes) were diagnosed with serpiginous choroiditis (SC) and one patient (two eyes) with acute posterior multifocal placoid pigment epitheliopathy (APMPPE). The patients were imaged on the same day using the RTVue Avanti XR instrument OCT/OCTA (Optovue Inc, Fremont, CA), Heidelberg Retina Angiograph 2 FAF and FA (Heidelberg Engineering, Germany), and TRC50DXi Topcon FP (Topcon Medical Systems, Oakland, NJ)...
September 29, 2017: Ocular Immunology and Inflammation
Mette K Christensen, Eva Lykkegaard, Ole Lund, Lotte D O'Neill
Recent years have seen leading medical educationalists repeatedly call for a paradigm shift in the way we view, value and use subjectivity in assessment. The argument is that subjective expert raters generally bring desired quality, not just noise, to performance evaluations. While several reviews document the psychometric qualities of the Multiple Mini-Interview (MMI), we currently lack qualitative studies examining what we can learn from MMI raters' subjectivity. The present qualitative study therefore investigates rater subjectivity or taste in MMI selection interview...
September 27, 2017: Advances in Health Sciences Education: Theory and Practice
Damla Ozcelik, Aadhar Jain, Alexandra Stambaugh, Matthew A Stott, Joshua W Parks, Aaron Hawkins, Holger Schmidt
Simultaneous detection of multiple pathogens and samples (multiplexing) is one of the key requirements for diagnostic tests in order to enable fast, accurate and differentiated diagnoses. Here, we introduce a novel, highly scalable, photonic approach to multiplex analysis with single virus sensitivity. A solid-core multimode interference (MMI) waveguide crosses multiple fluidic waveguide channels on an optofluidic chip to create multi-spot excitation patterns that depend on both the wavelength and location of the channel along the length of the MMI waveguide...
September 22, 2017: Scientific Reports
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